Carbomer gel swelling degree testing method

Abstract

The invention provides a method for testing the swelling degree of carbomer gel, which comprises the following steps: testing the swelling degree of the carbomer gel under the conditions of the same electrolyte and different concentrations of solvents to obtain a first swelling degree corresponding to each selected sol; determining the contribution degree of the hydrophilicity of the carbomer gel to the swelling degree change based on all the first swelling degrees; testing the swelling degrees of the carbomer gel under different electrolytes and different concentrations of solvents to obtain second swelling degrees corresponding to the selected sols; based on all the second swelling degrees, the wrapping amount of molecular chains in the carbomer gel to the solvent under the unit ion strength is determined; determining the swelling responsiveness of the swelling degree of the carbomer gel to the ionic strength change in the solvent according to the contribution degree and the wrapping amount, and generating a swelling degree test result based on the swelling responsiveness. By adopting the scheme provided by the invention, the transfer relationship between the swelling degree of the carbomer gel and the ionic strength in the solvent can be established, so that the universality of the test result of the swelling degree of the carbomer gel is improved.

Description

Technical Field

[0001] The present application relates to the technical field of compatibility testing, and more specifically, to a method for testing the swelling degree of carbomer gel. Background Art

[0002] Compatibility testing is a common experimental method used to determine whether different materials, chemicals, components or systems can be compatible with each other in a certain environment without adverse reactions or failure. This type of testing is widely used in many fields, including medicine, chemical engineering, food science, materials science, biology, etc.

[0003] The swelling test of gel is one of the compatibility tests of gel. When evaluating the interaction between gel materials and solvents or other environmental factors (such as temperature, pH value, ion concentration, etc.), the swelling test helps to evaluate the compatibility of gel materials in different media. In the prior art, carbomer gel is usually tested for swelling by weight method, volume method and image analysis method. However, these three methods only detect the swelling of carbomer gel in a specific solvent. In the actual application of carbomer gel, carbomer gel will come into contact with solvents of various ionic strengths, which results in the lack of versatility of existing carbomer gel swelling test methods. Therefore, how to establish the transfer relationship between the swelling of carbomer gel and the ionic strength in the solvent, and then improve the versatility of the carbomer gel swelling test results has become a difficult problem faced by the industry. Summary of the invention

[0004] The present application provides a carbomer gel swelling test method, which can establish a transfer relationship between the swelling degree of carbomer gel and the ionic strength in the solvent, thereby improving the versatility of the carbomer gel swelling test results.

[0005] In a first aspect, the present application provides a method for testing the swelling degree of carbomer gel, the method comprising: Prepare a sample of carbomer gel and prepare the test equipment required for the test, wherein the test equipment includes a centrifuge and an intelligent sensor; Performing a first swelling degree test on a sample of the carbomer coagulant under the same electrolyte and different concentrations of solvents by using the centrifuge, and detecting the first swelling degree corresponding to each selected solvent during the first swelling degree test based on the intelligent sensor; Determining the order of change of free energy related to the hydrophilicity of the carbomer gel based on all the first swelling degrees, and then determining the contribution of the hydrophilicity of the carbomer gel to the change of the swelling degree according to the order of change; Performing a second swelling degree test on a sample of the carbomer coagulant under different electrolytes and solvents of different concentrations by using the centrifuge, and detecting the second swelling degree corresponding to each selected solvent during the second swelling degree test based on the intelligent sensor; Determine the nonlinear deviation caused by the cross-linking degree of the carbomer gel on the change of the swelling degree of the carbomer gel based on all the second swelling degrees, and then determine the amount of solvent encapsulation by the molecular chains in the carbomer gel at unit ionic strength according to the nonlinear deviation; The swelling responsiveness of the carbomer gel swelling degree to the change of the ionic strength in the solvent is determined according to the contribution and the encapsulation amount, and the swelling degree test result is generated based on the swelling responsiveness.

[0006] In some embodiments, preparing a sample of carbomer gel means taking any weight of carbomer gel and placing it in a drying oven to dry for a preset period of time, and using the dried carbomer gel as the sample of carbomer gel.

[0007] In some embodiments, the first swelling degree test of the carbomer gel sample under the same electrolyte and different concentration solvents is performed by the centrifuge, and the first swelling degree corresponding to each selected solvent during the first swelling degree test is detected by the smart sensor specifically includes: Selecting an electrolyte, and preparing a plurality of solvents with different electrolyte concentrations according to the electrolyte; selecting a solvent as a first selected solvent; Weighing the carbomer gel sample by the intelligent sensor to obtain a first sample mass; Adding a sample of carbomer gel and a first selected solvent into a dry centrifuge tube and stirring; The stirred centrifuge tube is placed in a centrifuge for centrifugation; Tilt the centrifuge tube after centrifugation and let it stand, then remove the solvent in the upper layer of the centrifuge tube, and weigh the centrifuge tube after the upper layer of solvent is removed by the intelligent sensor to obtain a first test mass; determining a first swelling degree of a first selected solvent corresponding to a first swelling degree test based on the first sample mass and the first test mass; The remaining other solvents are selected to continue to obtain the first swelling degree of the remaining solvents corresponding to the first swelling degree test.

[0008] In some embodiments, determining the order of change of free energy associated with the hydrophilicity of the carbomer gel based on all first swelling degrees specifically comprises: Convert all first swelling degrees into first swelling degree sequences; determining a first difference sequence of the first swelling degree sequence; Determining the amount of change in free energy associated with the hydrophilicity of the carbomer gel in each first swelling degree test according to the first differential sequence; The order of change of free energy related to the hydrophilicity of carbomer gel was determined based on the amount of change of all free energies.

[0009] In some embodiments, determining the change in free energy associated with the hydrophilicity of the carbomer gel in each first swelling degree test according to the first differential sequence specifically includes: Preset a plurality of solvent solubility offset coefficients, and determine a solubility offset sequence corresponding to each offset coefficient according to each offset coefficient and the first differential sequence; The change in free energy associated with the hydrophilicity of the carbomer gel was determined for each first swelling test for all solubility excursion sequences.

[0010] In some embodiments, determining the contribution of the hydrophilicity of the carbomer gel to the change in swelling degree according to the change order specifically includes: constructing a fitting model for the first swelling degree test according to the change order; All first swelling degrees and the concentration of the solvent corresponding to each first swelling degree are fitted according to the fitting model, thereby obtaining the contribution of the hydrophilicity of the carbomer gel to the change in swelling degree.

[0011] In some embodiments, the second swelling degree test of the carbomer gel sample under different electrolytes and different concentrations of solvents is performed by the centrifuge, and the second swelling degree corresponding to each selected solvent during the second swelling degree test is detected by the smart sensor specifically includes: Select multiple electrolytes, and prepare multiple solvents with different electrolytes and different concentrations based on all the electrolytes; selecting a solvent as a second selected solvent; Weighing the carbomer gel sample by the intelligent sensor to obtain a second sample mass; Adding a sample of the carbomer gel and a second selected solvent into a dry centrifuge tube and stirring; The stirred centrifuge tube is placed in a centrifuge for centrifugation; Tilt the centrifuge tube after centrifugation and let it stand, then remove the solvent in the upper layer of the centrifuge tube, and weigh the centrifuge tube after the upper layer of solvent is removed by the intelligent sensor to obtain a second test mass; determining a second swelling degree of a second selected solvent corresponding to a second swelling degree test based on the second sample mass and the second test mass; The remaining other solvents are selected to continue to obtain the second swelling degree of the remaining solvents corresponding to the second swelling degree test.

[0012] In some embodiments, the centrifuge is a floor-standing low-speed electric centrifuge.

[0013] In some embodiments, the smart sensor is an integrated sensor for weighing and measuring temperature.

[0014] In some embodiments, generating a swelling degree test result based on the swelling responsiveness means drawing a swelling degree curve graph of the carbomer gel according to the swelling responsiveness, and using the swelling degree curve graph as the swelling degree test result.

[0015] The technical solution provided by the embodiments disclosed in this application has the following beneficial effects: In the carbomer gel swelling test method provided in the present application, first, a sample of carbomer gel is prepared, and a test device required for the test is prepared, wherein the test device includes a centrifuge and an intelligent sensor; a first swelling test is performed on the sample of carbomer gel under the same electrolyte and different concentration solvents by the centrifuge, and the first swelling degree corresponding to each selected solvent during the first swelling test is detected by the intelligent sensor; based on all the first swelling degrees, the change order of free energy related to the hydrophilicity of the carbomer gel is determined, and then the contribution of the hydrophilicity of the carbomer gel to the change in swelling degree is determined according to the change order; The centrifuge performs a second swelling degree test on a sample of the carbomer gel under different electrolytes and solvents of different concentrations, and detects the second swelling degrees corresponding to each selected solvent during the second swelling degree test based on the intelligent sensor; based on all the second swelling degrees, the nonlinear deviation caused by the cross-linking degree of the carbomer gel on the swelling degree change of the carbomer gel is determined, and then the amount of solvent encapsulation by the molecular chains in the carbomer gel under unit ionic strength is determined according to the nonlinear deviation; the swelling responsiveness of the carbomer gel swelling degree to the change of ionic strength in the solvent is determined according to the contribution degree and the encapsulation amount, and the swelling degree test result is generated based on the swelling responsiveness.

[0016] It can be seen that the present application tests the swelling degree of carbomer gel under the same electrolyte and different concentration solvents, and then evaluates the contribution of the hydrophilicity of carbomer gel to the swelling degree change through the change characteristics of the test results (i.e., the order of change of free energy), and then evaluates the contribution of the hydrophilicity of carbomer gel to the swelling degree change through the linear change characteristics; then, the swelling degree of carbomer gel is tested by different electrolytes and different concentration solvents, that is, the nonlinear deviation caused by the cross-linking degree of carbomer gel to the swelling degree change of carbomer gel in solvents with different molecular weights is obtained, and then the amount of the molecular chain in the carbomer gel wrapped in the aqueous solution under unit ionic strength is determined through the nonlinear deviation, and finally the nonlinear characteristics of the swelling degree of carbomer gel with ionic strength change are determined through the contribution and the wrapped amount, and then the swelling responsiveness of carbomer gel to the change of ionic strength in the solvent is fitted through the nonlinear characteristics, and the final swelling degree test result is generated based on the swelling responsiveness. In summary, the present application can establish the transfer relationship between the swelling degree of carbomer gel and the ionic strength in the solvent, thereby improving the versatility of the swelling degree test results of carbomer gel. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 is an exemplary flow chart of a method for testing the swelling degree of carbomer gel according to some embodiments of the present application; Figure 2 is a schematic diagram of the structure of a centrifuge according to some embodiments of the present application; Figure 3 is an exemplary flow chart of a first swelling degree test according to some embodiments of the present application; Figure 4 is an exemplary flow chart for determining swelling responsiveness according to some embodiments of the present application Figure 5 is a swelling curve diagram of carbomer gel according to some embodiments of the present application; Figure 6 It is a schematic diagram of the structure of a carbomer gel swelling test device according to some embodiments of the present application. DETAILED DESCRIPTION

[0018] In order to better understand the technical solution of the present application, the technical solution of the present application will be described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0019] refer to Figure 1 , which is an exemplary flow chart of a carbomer gel swelling test method according to some embodiments of the present application, and the carbomer gel swelling test method 100 mainly includes the following steps: In step 101, a sample of carbomer gel is prepared, and a test device required for the test is prepared, wherein the test device includes a centrifuge and an intelligent sensor.

[0020] In some embodiments, preparing a sample of carbomer gel means taking any weight of carbomer gel and placing it in a drying oven to dry for a preset period of time, and using the dried carbomer gel as the sample of carbomer gel.

[0021] It should be noted that the preset time period in the present application is usually preset to any value not less than 24 hours. For example, the preset time period is preset to 24 hours in the present application. Those skilled in the art know that the preset time period can also be preset to any other value not less than 24 hours, which falls within the protection scope of the present invention and will not be repeated here.

[0022] In some embodiments, reference Figure 2 , which is a structural schematic diagram of a centrifuge shown in some embodiments of the present application. The centrifuge is a floor-standing low-speed electric centrifuge, and the centrifuge specifically includes: a centrifuge body, a centrifuge control console, a touch display screen, a positioning groove, a centrifuge drum, a machine cover and a positioning iron column.

[0023] In some embodiments, the smart sensor is an integrated sensor for weighing and measuring temperature.

[0024] In specific implementation, the test equipment required for the test can be prepared in the following manner, namely: the integrated sensor is zero-calibrated to eliminate the measurement error of the integrated sensor, and the centrifuge is tested at no-load and low speed to ensure that the centrifuge operates normally.

[0025] In step 102, a first swelling degree test is performed on a sample of the carbomer coagulant under the same electrolyte and different concentrations of solvents by the centrifuge, and the first swelling degree corresponding to each selected solvent during the first swelling degree test is detected based on the smart sensor.

[0026] In some embodiments, reference Figure 3 , which is an exemplary flow chart of the first swelling degree test according to some embodiments of the present application. In the present application, the first swelling degree test of the carbomer coagulant sample under the same electrolyte and different concentration solvents is performed by the centrifuge, and the first swelling degree corresponding to each selected solvent during the first swelling degree test is detected by the smart sensor. The following steps can be used to achieve: In step 1021, an electrolyte is selected, and a plurality of solvents with different electrolyte concentrations are prepared according to the electrolyte; In step 1022, a solvent is selected as a first selected solvent; In step 1023, the carbomer gel sample is weighed by the smart sensor to obtain a first sample mass; In step 1024, a sample of carbomer gel and a first selected solvent are added to a dry centrifuge tube and stirred; In step 1025, the stirred centrifuge tube is placed in a centrifuge for centrifugation; In step 1026, the centrifuge tube after centrifugation is tilted and allowed to stand, and then the solvent in the upper layer of the centrifuge tube is removed, and the centrifuge tube after the upper layer of the solvent is removed is weighed by the intelligent sensor to obtain a first test mass; In step 1027, a first swelling degree of a first selected solvent corresponding to a first swelling degree test is determined based on the first sample mass and the first test mass; In step 1028, the remaining other solvents are selected to continue to obtain the first swelling degree of the remaining solvents corresponding to the first swelling degree test.

[0027] In specific implementation, the first swelling degree test of the carbomer gel sample under the same electrolyte and different concentration solvents is performed by the centrifuge, and the first swelling degree corresponding to each selected solvent during the first swelling degree test is detected based on the intelligent sensor. The following method can be used to achieve the test, namely: the carbomer gel sample is weighed by the intelligent sensor, and the obtained mass is used as the first sample mass, and the carbomer gel sample is placed in a dry centrifuge tube. Subsequently, the first selected solvent is added to the dry centrifuge tube and stirred, and stirred again after 15 minutes. After 15 minutes of the second stirring, the centrifuge is centrifuged at a preset centrifugal speed for 20 minutes, and then the centrifuge tube is tilted to remove the upper solvent, and the centrifuge tube is weighed again, and the obtained mass is used as the first test mass, wherein the centrifugal speed can be preset according to actual needs. For example, in the present application, the centrifugal speed can be preset to 4000r / min.

[0028] In specific implementation, the first swelling degree of the first selected solvent corresponding to the first swelling degree test can be determined according to the first sample mass and the first test mass in the following manner, namely: subtract the mass of the centrifuge tube from the first test mass, and divide the obtained value by the first sample mass, and use the obtained quotient as the first swelling degree of the first selected solvent corresponding to the first swelling degree test. It should be noted that in this application, the same electrolyte and solvents of different concentrations are multiple solvents prepared in advance. For example, ammonium chloride can be selected as the electrolyte in the solvent in this application, and the concentration of the solvent is preset to eight concentrations of 0.5g / L, 1.0g / L, 2.0g / L, 5.0g / L, 1.0g / L, 25g / L, 50g / L and 100g / L.

[0029] It should be noted that the "first" and "second" in the present application do not represent the order of precedence, nor do they limit the first swelling degree test of the carbomer gel. They are only used to distinguish the swelling degrees obtained by the two first swelling degree tests. For example, the first and second swelling degrees in the first swelling degree and the second swelling degree are only used to distinguish to indicate that these are the swelling degrees obtained by the first swelling degree tests of different processes.

[0030] In addition, it should be noted that in the present application, the temperature in the centrifuge tube during each first swelling degree test can be collected by the intelligent sensor, and the temperature during each first swelling degree test can be kept constant by a heating device and a cooling device.

[0031] In step 103, the change order of the free energy related to the hydrophilicity of the carbomer gel is determined based on all the first swelling degrees, and then the contribution of the hydrophilicity of the carbomer gel to the change in swelling degree is determined according to the change order.

[0032] In some embodiments, determining the order of change of free energy associated with the hydrophilicity of the carbomer gel based on all first swelling degrees can be achieved by the following steps: Convert all first swelling degrees into first swelling degree sequences; determining a first difference sequence of the first swelling degree sequence; Determining the amount of change in free energy associated with the hydrophilicity of the carbomer gel in each first swelling degree test according to the first differential sequence; The order of change of free energy related to the hydrophilicity of carbomer gel was determined based on the amount of change of all free energies.

[0033] In specific implementation, converting all first swelling degrees into the first swelling degree sequence can be achieved in the following manner, that is, all first swelling degrees can be sorted from small to large according to the concentration of the solvent used in the first swelling degree test, and the sorted sequence is used as the first swelling degree sequence.

[0034] In a specific implementation, determining the first differential sequence of the first swelling degree sequence can be achieved in the following manner, namely: selecting two adjacent first swelling degrees in the first swelling degree sequence, subtracting the first swelling degree at the rear from the first swelling degree, and then using the difference obtained by the subtraction as the differential value corresponding to the selected two first swelling degrees, then selecting the other two adjacent first swelling degrees in the first swelling degree sequence, and continuing to obtain the differential value corresponding to each of the remaining two adjacent first swelling degrees, and finally arranging all the obtained differential values ​​according to the arrangement order of the first swelling degrees in the first swelling degree sequence, and using the sequence obtained by the arrangement as the first differential sequence.

[0035] In some embodiments, determining the change in free energy related to the hydrophilicity of the carbomer gel in each first swelling degree test according to the first differential sequence can be achieved by the following steps: Preset a plurality of solvent solubility offset coefficients, and determine a solubility offset sequence corresponding to each offset coefficient according to each offset coefficient and the first differential sequence; The change in free energy associated with the hydrophilicity of the carbomer gel was determined for each first swelling test for all solubility excursion sequences.

[0036] It should be noted that the offset coefficient of the solvent solubility in the present application is a parameter used for offset comparison of the solvent concentration and the first swelling degree in the first swelling degree test. The offset comparison refers to comparing the first swelling degrees corresponding to different solvent concentrations. The offset coefficient can be preset according to actual needs. For example, in the present application, the offset coefficient can be preset to 1, 2, 3, 4, and 5 respectively.

[0037] In specific implementation, determining the solubility offset sequence corresponding to each offset coefficient based on each offset coefficient and the first differential sequence can be achieved in the following manner, namely: for each offset coefficient, adding n zeros before the first differential value in the first differential sequence, and using the obtained sequence as the solubility offset sequence corresponding to the offset coefficient, wherein n is the offset coefficient of the solvent solubility.

[0038] It should be noted that the solubility offset sequence in the present application refers to a sequence after the corresponding relationship between the differential value and the solvent concentration is offset. For example, for a solubility offset sequence with an offset coefficient of a, the bth differential value in the first differential sequence corresponds to the b+ath value in the solubility offset sequence, that is, each differential value is offset by a.

[0039] In specific implementation, determining the amount of change in free energy associated with the hydrophilicity of the carbomer gel in each first swelling degree test according to all solubility offset sequences can be achieved in the following manner, namely: first, selecting a solubility offset sequence as the selected solubility offset sequence, subtracting the average value of the first differential sequence from the first value in the selected solubility offset sequence, and using the obtained value as the first deviation of the selected solubility offset sequence; then, adding i zeros after the last differential value in the first differential sequence, so that the length of the added sequence is equal to that of the selected solubility offset sequence; subtracting the average value of the first differential sequence from the first differential value in the added sequence, and using the obtained value as the first deviation of the first differential sequence; and multiplying the first deviation of the selected solubility offset sequence by the first deviation of the first differential sequence; then, dividing the obtained value by the variance of the first differential sequence, and using the value obtained after the division as the amount of change in free energy associated with the hydrophilicity of the carbomer gel in the first first swelling degree test; finally, selecting the remaining solubility offset sequences as the selected solubility offset sequences, and repeating the above steps to obtain the amount of change in free energy associated with the hydrophilicity of the carbomer gel in each first swelling degree test.

[0040] It should be noted that the change in free energy in the present application is a parameter indicating the degree of change in free energy generated when the carbomer gel interacts with the solvent. The larger the change, the greater the free energy change generated by the interaction between the carbomer gel and the solvent in the first swelling degree test, and the smaller the change, the less the free energy change generated by the interaction between the carbomer gel and the solvent in the first swelling degree test.

[0041] In specific implementation, determining the order of change of free energy related to the hydrophilicity of carbomer gel according to the change of all free energies can be achieved in the following manner, namely: first, all the changes of free energy are arranged from small to large in the order of the solvent concentration in the corresponding first swelling degree test, and then, each change in the arranged sequence is compared with a preset change threshold in turn, and if the kth change is less than the preset change threshold for the first time, k is taken as the order of change of free energy related to the hydrophilicity of carbomer gel.

[0042] It should be noted that the change threshold is usually preset to a small positive number. For example, the change threshold can be preset to 0.05. Those skilled in the art know that the change threshold can be preset to other values ​​according to actual needs, which falls within the protection scope of the present invention and will not be repeated here.

[0043] It should be noted that the order of change of free energy in the present application is a parameter indicating the complexity of the change in the free energy of the carbomer gel in the swelling test as the solvent concentration changes. The larger the order of change, the more complex the change in the free energy related to the hydrophilicity of the carbomer gel in the first swelling test as the solvent concentration changes. The smaller the order of change, the less complex the change in the free energy related to the hydrophilicity of the carbomer gel in the first swelling test as the solvent concentration changes.

[0044] In some embodiments, determining the contribution of the hydrophilicity of the carbomer gel to the change in swelling degree according to the change order can be achieved by the following steps: constructing a fitting model for the first swelling degree test according to the change order; All first swelling degrees and the concentration of the solvent corresponding to each first swelling degree are fitted according to the fitting model, thereby obtaining the contribution of the hydrophilicity of the carbomer gel to the change in swelling degree.

[0045] In specific implementation, constructing a fitting model for the first swelling degree test according to the change order can be achieved in the following manner, namely: selecting an autoregressive model in the prior art, and setting the maximum order of the dependent variable in the autoregressive model to the same value as the change order, and then using the obtained autoregressive model as the fitting model for the first swelling degree test.

[0046] In a specific implementation, all the first swelling degrees and the concentration of the solvent corresponding to each first swelling degree are fitted according to the fitting model, and then the contribution of the hydrophilicity of the carbomer gel to the change in swelling degree is obtained. This can be achieved in the following way, namely: all the first swelling degrees and the concentration of the solvent corresponding to each first swelling degree are input into the fitting model for fitting, and the intercept of the fitted function is used as the contribution of the hydrophilicity of the carbomer gel to the change in swelling degree.

[0047] It should be noted that the contribution in the present application is a parameter indicating the degree to which the hydrophilicity of the carbomer gel promotes the water molecules in the solvent to enter the carbomer gel. The greater the contribution, the more the hydrophilicity of the carbomer gel promotes the water molecules in the solvent to enter the carbomer gel in the first swelling degree test. The smaller the contribution, the less the hydrophilicity of the carbomer gel promotes the water molecules in the solvent to enter the carbomer gel in the first swelling degree test.

[0048] In addition, it should be noted that the stronger the hydrophilicity of carbomer gel, the easier it is for the gel molecular chains to interact with water molecules to form attractive forces such as hydrogen bonds. The greater this interaction, the more water will enter the gel structure, increasing the swelling degree, that is, the greater the contribution of hydrophilicity to the change in swelling degree.

[0049] In step 104, the centrifuge is used to perform a second swelling degree test on the carbomer gel sample under different electrolytes and different concentrations of solvents, and the smart sensor is used to detect the second swelling degree corresponding to each selected solvent during the second swelling degree test.

[0050] In some embodiments, the second swelling degree test of the carbomer gel sample under different electrolytes and different concentrations of solvents is performed by the centrifuge, and the second swelling degree corresponding to each selected solvent during the second swelling degree test is detected by the smart sensor can be achieved by the following steps: Select multiple electrolytes, and prepare multiple solvents with different electrolytes and different concentrations based on all the electrolytes; selecting a solvent as a second selected solvent; Weighing the carbomer gel sample by the intelligent sensor to obtain a second sample mass; Adding a sample of the carbomer gel and a second selected solvent into a dry centrifuge tube and stirring; The stirred centrifuge tube is placed in a centrifuge for centrifugation; Tilt the centrifuge tube after centrifugation and let it stand, then remove the solvent in the upper layer of the centrifuge tube, and weigh the centrifuge tube after the upper layer of solvent is removed by the intelligent sensor to obtain a second test mass; determining a second swelling degree of a second selected solvent corresponding to a second swelling degree test based on the second sample mass and the second test mass; The remaining other solvents are selected to continue to obtain the second swelling degree of the remaining solvents corresponding to the second swelling degree test.

[0051] In specific implementation, the second swelling degree test of the carbomer gel sample under different electrolytes and different concentrations of solvents by the centrifuge can be achieved in the following manner, namely: first, the carbomer gel sample is weighed by the intelligent sensor, and the obtained mass is used as the second sample mass, and the carbomer gel sample is placed in a dry centrifuge tube, and then the second selected solvent is added to the dry centrifuge tube and stirred, and stirred again after 15 minutes, and centrifuged at a preset centrifugal speed for 20 minutes after 15 minutes of the second stirring, and then, the centrifuge tube is tilted to remove the upper solvent, and the centrifuge tube is weighed again, and the obtained mass is used as the second test mass, wherein the centrifugal speed can be preset according to actual needs. For example, the centrifugal speed can be preset to 4000r / min in the present application.

[0052] In specific implementation, determining the second swelling degree of the second selected solvent corresponding to the second swelling degree test according to the second sample mass and the second test mass can be achieved in the following manner, namely: subtracting the mass of the centrifuge tube from the second test mass, and dividing the obtained value by the second sample mass, and using the obtained quotient as the second swelling degree of the second selected solvent corresponding to the second swelling degree test.

[0053] It should be noted that different electrolytes and solvents of different concentrations in the present application refer to multiple solvents that have been prepared in advance. For example, in the present application, six monovalent cation electrolytes, namely ammonium chloride, ammonium nitrate, potassium nitrate, potassium chloride, ammonium bicarbonate and dipotassium hydrogen phosphate, can be selected as electrolytes in the solvent, and the concentrations of the solvents can be preset to eight concentrations of 0.5g / L, 1.0g / L, 2.0g / L, 5.0g / L, 1.0g / L, 25g / L, 50g / L and 100g / L, that is, there are a total of 48 solvents with different electrolytes and different concentrations. In other embodiments, other electrolytes or solvents of other concentrations may also be used, which are not limited here.

[0054] In addition, it should be noted that the "first" and "second" in the present application do not represent a sequence of precedence, nor do they limit the test operation. They are only used to distinguish the swelling degrees obtained from the two tests. For example, the first and second in the first swelling degree and the second swelling degree are only used to distinguish to indicate that these are swelling degrees obtained by different test processes.

[0055] In addition, it should be noted that in the present application, the temperature in the centrifuge tube during each second swelling degree test can be collected by the intelligent sensor, and the temperature during each second swelling degree test can be kept constant by a heating device and a cooling device.

[0056] In step 105, the nonlinear deviation caused by the cross-linking degree of the carbomer gel on the change of the swelling degree of the carbomer gel is determined based on all the second swelling degrees, and then the amount of solvent encapsulation by the molecular chains in the carbomer gel under a certain ionic strength is determined according to the nonlinear deviation.

[0057] In some embodiments, determining the nonlinear deviation caused by the cross-linking degree of the carbomer gel on the change of the swelling degree of the carbomer gel based on all the second swelling degrees can be achieved by the following steps: converting all second swelling degrees into a second swelling degree sequence; determining a second difference sequence of the second swelling degree sequence; Determine, according to the second differential sequence, the swelling deviation caused by the cross-linking degree of the carbomer gel on the test result in each second swelling degree test; The nonlinear deviation of the carbomer gel swelling degree caused by the cross-linking degree of the carbomer gel was determined based on all the swelling deviations.

[0058] In specific implementation, converting all the second swelling degrees into the second swelling degree sequence can be achieved in the following manner, that is, all the second swelling degrees can be sorted from small to large according to the molecular weight of the solvent used in the second swelling degree test, and the sorted sequence is used as the second swelling degree sequence.

[0059] In a specific implementation, determining the second differential sequence of the second swelling degree sequence can be achieved in the following manner, namely: selecting two adjacent second swelling degrees in the second swelling degree sequence, subtracting the first second swelling degree from the second swelling degree at the rear, and then using the difference obtained by the subtraction as the differential value corresponding to the selected two second swelling degrees, then selecting the other two adjacent second swelling degrees in the second swelling degree sequence, and continuing to obtain the differential value corresponding to each of the remaining two adjacent second swelling degrees, and finally arranging all the obtained differential values ​​according to the arrangement order of the second swelling degrees in the second swelling degree sequence, and using the sequence obtained by the arrangement as the second differential sequence.

[0060] In some embodiments, determining the swelling deviation caused by the cross-linking degree of the carbomer gel on the test result in each second swelling degree test according to the second differential sequence can be achieved by the following steps: Preset a plurality of solvent molecular weight offset coefficients, and determine a molecular weight offset sequence corresponding to each offset coefficient according to each offset coefficient and the second differential sequence; The swelling deviation caused by the cross-linking degree of the carbomer gel on the test results in each second swelling test was determined based on all molecular weight deviation sequences.

[0061] It should be noted that the offset coefficient of the solvent molecular weight in the present application is a parameter used for offset comparison of the solvent molecular weight and the second swelling degree in the second swelling degree test. The offset comparison refers to comparing the second swelling degrees corresponding to different molecular weights. The offset coefficient can be preset according to actual needs. For example, in the present application, the offset coefficient can be preset to 1, 2, 3, 4, and 5 respectively.

[0062] In specific implementation, determining the molecular weight offset sequence corresponding to each offset coefficient based on each offset coefficient and the second differential sequence can be achieved in the following manner, namely: for each offset coefficient, adding m zeros before the second differential value in the second differential sequence, and using the obtained sequence as the molecular weight offset sequence corresponding to the offset coefficient, wherein m is the offset coefficient of the solvent molecular weight.

[0063] It should be noted that the molecular weight offset sequence in the present application refers to a sequence after the corresponding relationship between the differential value and the solvent molecular weight is offset. For example, for a molecular weight offset sequence with an offset coefficient of x, the yth differential value in the second differential sequence corresponds to the y+xth value in the molecular weight offset sequence, that is, each differential value is offset by x.

[0064] In specific implementation, the swelling deviation caused by the cross-linking degree of carbomer gel on the test result in each second swelling degree test according to all molecular weight offset sequences can be determined in the following manner, namely: first, a molecular weight offset sequence is selected as a selected molecular weight offset sequence, then j zeros are added after the last differential value of the second differential sequence, so that the added sequence has the same length as the selected molecular weight offset sequence, then the added sequence and the selected molecular weight offset sequence are input into the Yule-Walker equation in the prior art, and the output result is used as the swelling deviation caused by the cross-linking degree of carbomer gel on the test result in the first second swelling degree test, and finally, the remaining molecular weight offset sequences are selected as the selected molecular weight offset sequences, and the above steps are repeated to obtain the swelling deviation caused by the cross-linking degree of carbomer gel on the test result in each second swelling degree test.

[0065] It should be noted that the swelling deviation in the present application is a parameter indicating the degree of loss of the swelling degree of the carbomer gel caused by the cross-linking degree of the carbomer gel. The larger the swelling deviation, the more loss of the swelling degree of the carbomer gel caused by the cross-linking degree of the carbomer gel in the second swelling degree test, that is, the greater the deviation of the swelling degree of the test result from the true value, the smaller the swelling deviation, in the second swelling degree test, the less loss of the swelling degree of the carbomer gel caused by the cross-linking degree of the carbomer gel, that is, the smaller the deviation of the swelling degree of the test result from the true value.

[0066] In specific implementation, the nonlinear deviation caused by the cross-linking degree of carbomer gel on the swelling degree change of carbomer gel can be determined based on all swelling deviations. The following method is adopted, namely: first, all swelling deviations are arranged from small to large according to the molecular weight in the solvent of the second swelling degree test. Then, each swelling deviation is sequentially compared with a preset deviation threshold in the arranged sequence. If the t-th swelling deviation is less than the deviation threshold for the first time, t is taken as the nonlinear deviation caused by the cross-linking degree of carbomer gel on the swelling degree change of carbomer gel.

[0067] It should be noted that the deviation threshold is usually preset to a small positive number. For example, the deviation threshold can be preset to 0.05. Those skilled in the art know that the deviation threshold can be preset to other values ​​according to actual needs, which falls within the protection scope of the present invention and will not be repeated here.

[0068] It should be noted that the nonlinear deviation in the present application is a parameter indicating the degree to which the relationship between the swelling degree of carbomer gel and the change in solution ionic strength deviates from the linear relationship. The larger the nonlinear deviation, the more the relationship between the swelling degree of carbomer gel and the change in solution ionic strength deviates from the linear relationship. The smaller the nonlinear deviation, the less the relationship between the swelling degree of carbomer gel and the change in solution ionic strength deviates from the linear relationship.

[0069] In some embodiments, determining the amount of solvent encapsulated by the molecular chains in the carbomer gel at a unit ionic strength according to the nonlinear deviation can be achieved by the following steps: constructing a moving average model for a second swelling degree test according to the nonlinear deviation; obtaining the ionic strength of each solvent in the second swelling test; All the second swelling degrees and the ionic strength of the solvent corresponding to each second swelling degree are fitted according to the moving average model, thereby obtaining the amount of solvent encapsulation by the molecular chains in the carbomer gel at unit ionic strength.

[0070] In specific implementation, constructing a moving average model for the second swelling degree test based on the nonlinear deviation can be achieved in the following manner, namely: the autoregressive moving average model in the prior art can be used as the moving average model for the second swelling degree test, the autoregressive order in the autoregressive moving average model is set to the same value as the change order in the present application, and the moving average order in the autoregressive moving average model is set to the same value as the nonlinear deviation in the present application, then, the difference order in the autoregressive moving average model is set to one, and finally, the autoregressive moving average model is used as the moving average model for the second swelling degree test.

[0071] In specific implementation, all the second swelling degrees and the ionic strength of the solvent corresponding to each second swelling degree are fitted according to the moving average model, and then the encapsulation amount of the solvent by the molecular chains in the carbomer gel under unit ionic strength is obtained. This can be achieved in the following manner, namely: all the second swelling degrees and the concentration of the solvent corresponding to each second swelling degree are input into the moving average model for fitting, the moving average function obtained by fitting is factorized, and the function is converted into a function with only one coefficient, and the coefficient is used as the encapsulation amount of the solvent by the molecular chains in the carbomer gel under unit ionic strength.

[0072] It should be noted that the encapsulation amount in the present application is a parameter of how much the molecular chains in the carbomer gel encapsulate the aqueous solution. The encapsulation amount refers to the amount of the aqueous solution encapsulated when the molecules in the carbomer gel form a network chain three-dimensional structure (i.e., molecular chain) from a random state to an extended state at a unit ionic strength. The larger the encapsulation amount, the more the molecules in the carbomer gel form a network chain three-dimensional structure when they change from a random state to an extended state at a unit ionic strength. The smaller the encapsulation amount, the less the molecules in the carbomer gel form a network chain three-dimensional structure when they change from a random state to an extended state at a unit ionic strength.

[0073] In addition, it should be noted that under unit ionic strength, due to the electroviscous effect, carbomer gel reacts with carboxylate ions in aqueous solution to form a counter-ion atmosphere, causing mutual repulsion between carboxylate ions on the molecular chain. When the molecules change from a random state to an extended state to form a three-dimensional network chain structure, the aqueous solution will be wrapped. When the electrolyte ion strength increases, the repulsion between carboxylate ions is reduced, the degree of molecular expansion decreases, and the molecular chains in the carbomer gel will be in a more curled state, which will lead to a decrease in the amount of wrapped solution, which is manifested macroscopically as a decrease in the swelling degree of the carbomer gel.

[0074] In step 106, the swelling responsiveness of the carbomer gel swelling degree to the change of the ionic strength in the solvent is determined according to the contribution and the encapsulation amount, and a swelling degree test result is generated based on the swelling responsiveness.

[0075] In some embodiments, reference Figure 4 , which is an exemplary flow chart for determining swelling responsiveness according to some embodiments of the present application. In the present application, the swelling responsiveness of the swelling degree of carbomer gel to the change of ionic strength in the solvent according to the contribution degree and the encapsulation amount can be achieved by the following steps: In step 1061, the intercept of the Flory equation is determined according to the contribution; In step 1062, the slope of Flory's equation is determined based on the package amount; In step 1063, the power of the dependent variable in the Flory equation is determined according to the nonlinear deviation; In step 1064, the Flory equation constructed by the intercept, the slope and the power of the dependent variable is used as the swelling responsiveness of the swelling degree of the carbomer gel to the change of the ionic strength in the solvent.

[0076] In specific implementation, determining the intercept of the Flory formula according to the contribution degree means taking the contribution degree as the intercept of the Flory formula; in addition, determining the slope of the Flory formula according to the package quantity means taking the package quantity as the slope of the Flory formula; further, determining the power of the dependent variable in the Flory formula according to the nonlinear deviation means taking the nonlinear deviation as the power of the dependent variable in the Flory formula.

[0077] It should be noted that the swelling responsiveness in the present application refers to the property that the swelling degree of the carbomer gel changes with the ionic strength in the solvent, which describes how the swelling degree of the carbomer gel changes accordingly when the ionic strength in the solvent changes.

[0078] In some embodiments, generating a swelling degree test result based on the swelling responsiveness means drawing a swelling degree curve graph of the carbomer gel according to the swelling responsiveness, and using the swelling degree curve graph as the swelling degree test result.

[0079] In a specific implementation, the swelling degree curve of the carbomer gel can be drawn according to the swelling responsiveness. The following method can be used, that is, the formula corresponding to the swelling responsiveness can be input into the Mathematica software, and the swelling degree curve can be generated by the Mathematica software. The swelling degree curve can be used as the swelling degree test result of the carbomer gel. In other embodiments, the swelling degree curve of the carbomer gel can also be drawn by other existing technologies, which is not limited here.

[0080] It should be noted that in the present application, all the first swelling degrees, the concentration of the solvent corresponding to each first swelling degree, all the second swelling degrees and the molecular weight of the electrolyte in the solvent corresponding to each second swelling degree can be recorded as test data in the test report; at the same time, the swelling degree curve diagram is recorded as a test result in the compatibility test report of the carbomer gel, which will not be repeated here.

[0081] In some embodiments, reference Figure 5 , which is a swelling degree curve of carbomer gel according to some embodiments of the present application. The change of swelling degree of carbomer gel under different ionic strength environments can be known through the curve.

[0082] In addition, in another aspect of the present application, in some embodiments, the present application provides a carbomer gel swelling test device. When it is specifically implemented, a sample of the carbomer gel is first prepared, and a test device required for the test is prepared, the test device includes a centrifuge and an intelligent sensor, and the test device is controlled by the carbomer gel swelling test device to perform the test, reference Figure 6 , which is a structural schematic diagram of a carbomer gel swelling test device according to some embodiments of the present application, the carbomer gel swelling test device 600 includes: a first test module 601, a first processing module 602, a second test module 603, a second processing module 604 and an execution module 605, which are respectively described as follows: The first test module 601 in the present application is mainly used to instruct the centrifuge to perform a first swelling degree test on the sample of the carbomer coagulant under the same electrolyte and different concentrations of solvents, and to detect the first swelling degree corresponding to each selected solvent during the first swelling degree test based on the smart sensor; A first processing module 602, in the present application, the first processing module 602 is mainly used to determine the change order of free energy related to the hydrophilicity of the carbomer gel based on all the first swelling degrees, and then determine the contribution of the hydrophilicity of the carbomer gel to the change of the swelling degree according to the change order; The second test module 603 in the present application is mainly used to instruct the centrifuge to perform a second swelling degree test on the sample of the carbomer coagulant under different electrolytes and different concentrations of solvents, and to detect the second swelling degree corresponding to each selected solvent during the second swelling degree test based on the smart sensor; The second processing module 604 in the present application is mainly used to determine the nonlinear deviation caused by the cross-linking degree of the carbomer gel on the change of the swelling degree of the carbomer gel based on all the second swelling degrees, and then determine the amount of solvent encapsulation by the molecular chains in the carbomer gel at unit ionic strength according to the nonlinear deviation; Execution module 605, in the present application, execution module 605 is mainly used to determine the swelling responsiveness of the carbomer gel swelling degree to the change of the ionic strength in the solvent according to the contribution degree and the encapsulation amount, and generate the swelling degree test result based on the swelling responsiveness.

[0083] In summary, in the carbomer gel swelling test method disclosed in the embodiment of the present application, first, a sample of carbomer gel is prepared, and a test device required for the test is prepared, wherein the test device includes a centrifuge and an intelligent sensor; a first swelling test is performed on the sample of carbomer gel under the same electrolyte and different concentration solvents by the centrifuge, and the first swelling degree corresponding to each selected solvent during the first swelling test is detected based on the intelligent sensor; based on all the first swelling degrees, the change order of free energy related to the hydrophilicity of the carbomer gel is determined, and then the contribution of the hydrophilicity of the carbomer gel to the change in swelling degree is determined according to the change order; The centrifuge is used to perform a second swelling degree test on a sample of the carbomer gel under different electrolytes and solvents of different concentrations, and the second swelling degrees corresponding to each selected solvent during the second swelling degree test are detected based on the intelligent sensor; based on all the second swelling degrees, the nonlinear deviation caused by the cross-linking degree of the carbomer gel on the swelling degree change of the carbomer gel is determined, and then the amount of solvent encapsulation by the molecular chains in the carbomer gel under unit ionic strength is determined according to the nonlinear deviation; the swelling responsiveness of the carbomer gel swelling degree to the change of ionic strength in the solvent is determined according to the contribution degree and the encapsulation amount, and the swelling degree test result is generated based on the swelling responsiveness.

[0084] It can be seen that the present application tests the swelling degree of carbomer gel under the same electrolyte and different concentration solvents, and then evaluates the contribution of the hydrophilicity of carbomer gel to the swelling degree change through the change characteristics of the test results (i.e., the order of change of free energy), and then evaluates the contribution of the hydrophilicity of carbomer gel to the swelling degree change through the linear change characteristics; then, the swelling degree of carbomer gel is tested by different electrolytes and different concentration solvents, that is, the nonlinear deviation caused by the cross-linking degree of carbomer gel to the swelling degree change of carbomer gel in solvents with different molecular weights is obtained, and then the amount of the molecular chain in the carbomer gel wrapped in the aqueous solution under unit ionic strength is determined through the nonlinear deviation, and finally the nonlinear characteristics of the swelling degree of carbomer gel with ionic strength change are determined through the contribution and the wrapped amount, and then the swelling responsiveness of carbomer gel to the change of ionic strength in the solvent is fitted through the nonlinear characteristics, and the swelling responsiveness is generated based on the swelling responsiveness. In summary, the present application can establish the transfer relationship between the swelling degree of carbomer gel and the ionic strength in the solvent, thereby improving the versatility of the swelling degree test results of carbomer gel.

[0085] Although the preferred embodiments of the present application have been described, those skilled in the art may make other changes and modifications to these embodiments once they have learned the basic creative concept. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments and all changes and modifications falling within the scope of the present application.

[0086] Obviously, those skilled in the art can make various changes and modifications to the present application without departing from the spirit and scope of the present application. Thus, if these modifications and variations of the present application fall within the scope of the claims of the present application and their equivalents, the present application is also intended to include these modifications and variations.

Claims

1. A method for testing the swelling degree of carbomer gel, characterized in that: The method comprises the following steps: Prepare a sample of carbomer gel and prepare the test equipment required for the test, wherein the test equipment includes a centrifuge and an intelligent sensor; Performing a first swelling degree test on a sample of carbomer gel under the same electrolyte and different concentrations of solvents by using the centrifuge, and detecting the first swelling degree corresponding to each selected solvent during the first swelling degree test based on the intelligent sensor; Determining the order of change of free energy related to the hydrophilicity of the carbomer gel based on all the first swelling degrees, and then determining the contribution of the hydrophilicity of the carbomer gel to the change of the swelling degree according to the order of change; Performing a second swelling degree test on a sample of the carbomer gel under different electrolytes and different concentrations of solvents by using the centrifuge, and detecting the second swelling degree corresponding to each selected solvent during the second swelling degree test based on the intelligent sensor; Determine the nonlinear deviation caused by the cross-linking degree of the carbomer gel on the change of the swelling degree of the carbomer gel based on all the second swelling degrees, and then determine the amount of solvent encapsulation by the molecular chains in the carbomer gel at unit ionic strength according to the nonlinear deviation; The swelling responsiveness of the carbomer gel swelling degree to the change of the ionic strength in the solvent is determined according to the contribution and the encapsulation amount, and the swelling degree test result is generated based on the swelling responsiveness.

2. The method according to claim 1, characterized in that The preparation of the carbomer gel sample refers to taking any weight of the carbomer gel and placing it in a drying oven to dry for a preset period of time, and taking the dried carbomer gel as the carbomer gel sample.

3. The method according to claim 1, characterized in that The first swelling degree test of the carbomer gel sample under the same electrolyte and different concentration solvents is performed by the centrifuge, and the first swelling degree corresponding to each selected solvent during the first swelling degree test is detected by the intelligent sensor specifically includes: Selecting an electrolyte, and preparing a plurality of solvents with different electrolyte concentrations according to the electrolyte; selecting a solvent as a first selected solvent; Weighing the carbomer gel sample by the intelligent sensor to obtain a first sample mass; Adding a sample of carbomer gel and a first selected solvent into a dry centrifuge tube and stirring; The stirred centrifuge tube is placed in a centrifuge for centrifugation; Tilt the centrifuge tube after centrifugation and let it stand, then remove the solvent in the upper layer of the centrifuge tube, and weigh the centrifuge tube after the upper layer of solvent is removed by the intelligent sensor to obtain a first test mass; determining a first swelling degree of a first selected solvent corresponding to a first swelling degree test based on the first sample mass and the first test mass; The remaining other solvents are selected to continue to obtain the first swelling degree of the remaining solvents corresponding to the first swelling degree test.

4. The method according to claim 1, characterized in that The order of change of free energy related to the hydrophilicity of carbomer gel based on all first swelling degrees specifically includes: Convert all first swelling degrees into first swelling degree sequences; determining a first difference sequence of the first swelling degree sequence; Determining the amount of change in free energy associated with the hydrophilicity of the carbomer gel in each first swelling degree test according to the first differential sequence; The order of change of free energy related to the hydrophilicity of carbomer gel was determined based on the amount of change of all free energies.

5. The method according to claim 4, characterized in that Determining the change in free energy related to the hydrophilicity of the carbomer gel in each first swelling degree test according to the first differential sequence specifically includes: Preset a plurality of solvent solubility offset coefficients, and determine a solubility offset sequence corresponding to each offset coefficient according to each offset coefficient and the first differential sequence; The change in free energy associated with the hydrophilicity of the carbomer gel was determined for each first swelling test for all solubility excursion sequences.

6. The method according to claim 1, characterized in that Determining the contribution of the hydrophilicity of the carbomer gel to the change in swelling degree according to the change order specifically includes: constructing a fitting model for the first swelling degree test according to the change order; All first swelling degrees and the concentration of the solvent corresponding to each first swelling degree are fitted according to the fitting model, thereby obtaining the contribution of the hydrophilicity of the carbomer gel to the change in swelling degree.

7. The method according to claim 1, characterized in that The second swelling degree test of the carbomer gel sample under different electrolytes and different concentrations of solvents is performed by the centrifuge, and the second swelling degree corresponding to each selected solvent during the second swelling degree test is detected by the intelligent sensor specifically includes: Select multiple electrolytes, and prepare multiple solvents with different electrolytes and different concentrations based on all the electrolytes; selecting a solvent as a second selected solvent; Weighing the carbomer gel sample by the intelligent sensor to obtain a second sample mass; Adding a sample of the carbomer gel and a second selected solvent into a dry centrifuge tube and stirring; The stirred centrifuge tube is placed in a centrifuge for centrifugation; Tilt the centrifuge tube after centrifugation and let it stand, then remove the solvent in the upper layer of the centrifuge tube, and weigh the centrifuge tube after the upper layer of solvent is removed by the intelligent sensor to obtain a second test mass; determining a second swelling degree of a second selected solvent corresponding to a second swelling degree test based on the second sample mass and the second test mass; The remaining other solvents are selected to continue to obtain the second swelling degree of the remaining solvents corresponding to the second swelling degree test.

8. The method according to claim 1, characterized in that The centrifuge is a floor-standing low-speed electric centrifuge.

9. The method according to claim 1, characterized in that The intelligent sensor is an integrated sensor for weighing and measuring temperature.

10. The method according to claim 1, characterized in that Generating the swelling degree test result based on the swelling responsiveness means drawing a swelling degree curve diagram of the carbomer gel according to the swelling responsiveness, and using the swelling degree curve diagram as the swelling degree test result.

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