Integrated incubation cleaning module of full-automatic single-molecule immunoassay device

Abstract

The invention discloses an integrated incubation cleaning module of a full-automatic single-molecule immunoassay device, the integrated incubation cleaning module comprises an outer shell, a cleaning disc and an incubation disc, the cleaning disc and the incubation disc are rotatably connected in the outer shell, the incubation disc is annular, the cleaning disc is located at the inner peripheral side position of the annular incubation disc, an adjustable supporting structure is further arranged in the outer shell, and the adjustable supporting structure is located at the inner peripheral side position of the annular incubation disc. The annular incubation plate is rotationally connected to the interior of the outer shell through an adjustable supporting structure; a reaction cup internal transfer mechanism is further arranged on the outer shell, the reaction cup is transferred between the cleaning disc and the incubation disc in the integrated incubation cleaning module through the reaction cup internal transfer mechanism, and the detected reaction cup is discarded out of the integrated incubation cleaning module through the reaction cup internal transfer mechanism. According to the immunoassay device, reaction cup transferring and reaction cup discarding are carried out from the interior of the integrated incubation cleaning module, so that the overall structure of the immunoassay device is simplified, and the overall cost of the immunoassay device is reduced.

Description

Technical Field

[0001] The invention relates to an integrated incubation and cleaning module, in particular to an integrated incubation and cleaning module of a full-automatic single-molecule immunoassay device, and belongs to the technical field of medical testing. Background Art

[0002] Since the first automatic chemical analysis instrument was manufactured, more than half a century of development has gone by, and the fully automatic immunoanalyzer has become mature in technology. The current fully automatic immunoanalyzer has the following characteristics: 1. A multi-degree-of-freedom robotic arm is used to coordinate the actions between various modules; 2. The instrument has extremely strong flexibility and can meet various analysis needs; 3. The test speed is fast and the continuous operation time is long without human intervention; 4. The combination of multiple technologies and complete automation of processing in the detection technology make the test results more accurate and more precise. The fully automatic immunoanalyzer can realize the steps of taking the reaction cup, adding specimens, adding reaction liquid, shaking, promoting reaction, measuring, calculating and analyzing, and cleaning in the experimental test process. It replaces manual operation, which not only saves labor costs, but more importantly, eliminates human errors and ensures the accuracy of the data. The fully automatic immunoanalyzer has the advantages of fast, efficient, high precision, and repeatable consistency. It has been widely used in processing, production, testing, life assistance and other fields, and it is bound to become a trend in the field of medical testing.

[0003] In the previous technology, the main process of the incubation and cleaning device in the immunoassay analyzer is to place the reaction cup with the sample and reagent added in an independent incubation module for heating and incubation, and then the reaction cup is taken out by a manipulator and placed in another cleaning module for magnetic separation and cleaning. Since incubation and cleaning are two completely independent modules, the overall volume of the immunoassay device is large, the structure is complex, and the cost is also high. Therefore, improvements have been made in the prior art, and the incubation plate responsible for incubation and the cleaning plate responsible for cleaning are coaxially arranged and integrated into an incubation and cleaning module. This reduces the overall volume of the immunoassay device compared to before.

[0004] During the working process, the position of the reaction cup needs to be switched back and forth between the cleaning tray and the incubation tray. In the integrated incubation and cleaning module, the prior art uses an external manipulator to perform this operation, that is, an external manipulator is used to take out the reaction cup on the cleaning tray and place it in the incubation tray, or to take out the reaction cup on the incubation tray and place it in the cleaning tray. In addition, when the detection is completed, when the reaction cup in the integrated incubation and cleaning module needs to be discarded, it is also necessary to use an external manipulator to take it out and then discard it. Therefore, in the prior art, when the reaction cup is transported and discarded, it is completed by a manipulator arranged outside the incubation and cleaning module, which still causes the problem of a larger overall volume of the entire immunoassay device to a certain extent.

[0005] The relevant patent documents retrieved are as follows: 1. A Chinese utility model patent with authorization announcement number CN207636603U and authorization announcement date July 20, 2018 discloses an incubation and cleaning device, including an incubation tray, a cleaning tray, a drive assembly and a heating assembly, wherein the incubation tray includes an incubation tray body for incubating samples in a reaction cup; the cleaning tray is coaxial with the incubation tray and is arranged in concentric circles, and the cleaning tray is used to perform multi-stage cleaning of magnetic particles in the reaction cup; the drive assembly is a coaxial drive structure, including two drive motors, which respectively drive the incubation tray and the cleaning tray to move independently; the heating assembly is located below the incubation tray and the cleaning tray, and is used to heat the incubation tray and the cleaning tray.

[0006] 2. A Chinese utility model patent with authorization announcement number CN217688992U and authorization announcement date October 28, 2022 discloses a sample analysis device, including: a reaction container supply unit for providing a reaction container to be used; an injection unit for injecting reagents and / or samples into the reaction container; an incubation disk unit for incubating the liquid in the reaction container; a cleaning disk unit for removing unbound components in the reaction system in the reaction container; a detection unit for detecting the analyte in the reaction container; the cleaning disk unit is sleeved on the outside of the incubation disk unit or inside and coaxially arranged, the cleaning tray unit and the incubation tray unit operate independently of each other; a reaction container transporting mechanism is used to transport the reaction container between the reaction container supply unit, the incubation tray unit and the cleaning tray unit; the reaction container supply unit is provided with a reaction container supply unit cup grabbing position, the incubation tray unit is provided with an incubation tray cup grabbing position, the cleaning tray unit is provided with a cleaning tray cup grabbing position, the reaction container supply unit cup grabbing position, the incubation tray cup grabbing position and the cleaning tray cup grabbing position are all located on the motion trajectory of the reaction container transporting unit.

[0007] The above patent documents disclose incubation and cleaning modules, but do not disclose technical solutions to the above technical problems.

[0008] In summary, how to design an integrated incubation and cleaning module for a fully automatic single-molecule immunoassay device so that external operations can be avoided as much as possible during the transportation and disposal of the reaction cup, and the setting of external related components can be reduced, thereby minimizing the overall volume of the immunoassay device, simplifying the overall structure of the immunoassay device, and reducing the overall cost of the immunoassay device is a technical problem that needs to be solved urgently. Summary of the invention

[0009] The technical problem to be solved by the present invention is to provide an integrated incubation and cleaning module for a fully automatic single-molecule immunoassay device in response to the defects in the prior art. The integrated incubation and cleaning module is used to transport and discard reaction cups from inside the integrated incubation and cleaning module, thereby changing the current external operation mode and reducing the setting of external related components, thereby minimizing the overall volume of the immunoassay device, simplifying the overall structure of the immunoassay device, and reducing the overall cost of the immunoassay device.

[0010] In order to solve the above technical problems, the technical solution adopted by the present invention is: an integrated incubation and cleaning module of a fully automatic single-molecule immunoassay device, comprising an outer shell and a cleaning tray and an incubation tray rotatably connected to the inside of the outer shell, the incubation tray is annular, and the cleaning tray is located at the inner circumference of the annular incubation tray, and an adjustable support structure is also provided inside the outer shell, and the annular incubation tray is rotatably connected to the inside of the outer shell through the adjustable support structure; an internal reaction cup transport mechanism is also provided on the outer shell, and the internal reaction cup transport mechanism is used to transport the reaction cup between the cleaning tray and the incubation tray inside the integrated incubation and cleaning module, and the internal reaction cup transport mechanism is used to discard the reaction cup after the detection is completed from the integrated incubation and cleaning module.

[0011] Preferably, the adjustable support structure includes at least two fixed horizontal guide wheel structures and at least one adjustable horizontal guide wheel structure arranged inside the outer shell. The at least two fixed horizontal guide wheel structures and at least one adjustable horizontal guide wheel structure are utilized to cooperate with the inner circumference of the annular incubation tray for transmission connection, so that the incubation tray is rotatably connected to the inside of the outer shell.

[0012] Preferably, the fixed-position horizontal guide wheel structure includes a support column 1 and a horizontal guide wheel 1 arranged on the top of the support column 1, and a guide groove that cooperates with the annular incubation tray is opened on the circumferential surface of the horizontal guide wheel 1. The position-adjustable horizontal guide wheel structure includes a support column 2 and a support column 3. A swing arm is hinged on the top of the support column 2, one end of the swing arm is hinged on the top of the support column 2, and a swing arm waist hole is opened on the other end of the swing arm. A screw 1 is passed through the swing arm waist hole and screwed into the top of the support column 3, so that the other end of the swing arm is locked to the top of the support column 3. A horizontal guide wheel 2 is arranged on the swing arm, and a guide groove that cooperates with the annular incubation tray is also opened on the circumferential surface of the horizontal guide wheel 2.

[0013] Preferably, the incubation tray comprises an upper ring body and a lower ring body, and the upper ring body is connected to the lower ring body as a whole; by inserting the inner circumference of the upper ring body into the guide groove of the horizontal guide wheel one and the guide groove of the horizontal guide wheel two, the incubation tray is rotatably connected to the inside of the outer shell.

[0014] Preferably, external teeth are provided on the outer peripheral surface of the upper ring body; a second driving mechanism is provided on the outer shell, and a transmission gear is provided on the output shaft of the second driving mechanism, which is meshed and connected with the external teeth of the upper ring body through the transmission gear, so that the incubation plate can be driven to rotate through the second driving mechanism.

[0015] Preferably, the cleaning disc comprises an upper disc body and a lower disc body, and the upper disc body and the lower disc body are connected as a whole; a driving mechanism 1 is provided on the outer shell, and the output shaft of the driving mechanism 1 is cooperatively connected with the center position of the lower disc body, so that the cleaning disc can be driven to rotate under the drive of the driving mechanism 1.

[0016] Preferably, along the circumference of the cleaning disk, a plurality of U-shaped grooves 1 for supporting the reaction cups are arranged on the lower disk body, and the U-shaped grooves 1 are arranged radially toward the lower disk body; along the circumference of the incubation disk, a plurality of U-shaped grooves 2 for supporting the reaction cups are arranged on the lower ring body of the incubation disk, and the U-shaped grooves 2 are arranged radially toward the lower ring body; When the reaction cup is transported between the cleaning tray and the incubation tray by using the internal transport mechanism of the reaction cup, a U-shaped groove 1 of the cleaning tray and a U-shaped groove 2 of the incubation tray are located on the same radial line.

[0017] Preferably, the internal transport mechanism of the reaction cup includes a connecting seat arranged on the outer shell, an X-axis moving device arranged on the connecting seat and a Z-axis moving device arranged on the X-axis moving device, a transport cylinder is arranged on the Z-axis moving device, and the X-axis moving device and the Z-axis moving device constitute a two-dimensional moving mechanism, and the X-axis is arranged along the radial direction of the cleaning tray and the incubation tray in the integrated incubation and cleaning module.

[0018] Preferably, the X-axis moving device includes a motor 1 arranged on the connecting seat and a screw rod 1 rotatably connected to the connecting seat through a bearing, the output shaft of the motor 1 is connected to the screw rod 1 in a transmission cooperation, and a nut seat 1 is also slidably connected to the connecting seat, the nut seat 1 is connected to the screw rod 1 in a cooperation manner to form a screw-nut mechanism 1, so that under the action of the motor 1, the nut seat 1 can be driven to move back and forth along the X-axis direction; the Y-axis moving device includes a motor 2 arranged on the nut seat 1 and a screw rod 2 rotatably connected to the nut seat 1 through a bearing, the output shaft of the stepper motor 2 is connected to the screw rod 2 in a transmission cooperation, and a nut seat 2 is also slidably connected to the nut seat 1, the nut seat 2 is connected to the screw rod 2 in a cooperation manner to form a screw-nut mechanism 2, so that under the action of the motor 2, the nut seat 2 can be driven to move up and down along the Y-axis direction; the transfer cylinder is connected to the nut seat 2.

[0019] Preferably, the transfer cylinder comprises an outer frame and a cylinder body arranged inside the outer frame, the cylinder body is a two-half structure, including a left half cylinder body and a right half cylinder body, support rod 1 and support rod 2 are respectively arranged on both sides of the left half cylinder body, support rod 3 and support rod 4 are respectively arranged on both sides of the right half cylinder body, spring 1 is arranged between support rod 1 and support rod 3, spring 2 is arranged between support rod 2 and support rod 4, the left half cylinder body and the right half cylinder body are closed together to form the cylinder body by spring 1 and spring 2, guide rod 1 and guide rod 2 are also respectively arranged on both sides of the left half cylinder body, guide rod 3 and guide rod 4 are respectively arranged on both sides of the right half cylinder body, and guide wheels are connected to each guide rod; A guide groove 1 and a guide groove 2 are respectively formed on two opposite side surfaces of the outer frame. When the cylinder body that is put together is placed in the outer frame, the guide wheels on the guide rods 1 and 3 cooperate with the guide groove 1, and the guide wheels on the guide rods 2 and 4 cooperate with the guide groove 2, so that the cylinder body is connected to the outer frame. A frame waist hole 1 and a frame waist hole 2 are also respectively formed on two opposite side surfaces of the outer frame. One end of the support rod 1 and the support rod 3 extends out of the frame waist hole 1, and one end of the support rod 2 and the support rod 4 extends out of the frame waist hole 2. A conical opening and closing guide plate is also provided on the bottom of the integrated incubation and cleaning module, and the opening and closing guide plate is located below the transfer cylinder. Rollers are provided on one end of the support rod one and the support rod three. The opening and closing guide plate cooperates with the roller of the transfer cylinder to separate the left half cylinder and the right half cylinder of the transfer cylinder.

[0020] The beneficial effect of the present invention is that when the reaction cup is transported and discarded, it is all done from the inside of the integrated incubation and cleaning module, which changes the current external operation mode and reduces the setting of external related components, thereby minimizing the overall volume of the immunoassay device, simplifying the overall structure of the immunoassay device, and reducing the overall cost of the immunoassay device. Through the overall design of the present invention, after the reaction cup enters the integrated incubation and cleaning module, it is no longer necessary to repeatedly enter and exit the integrated incubation and cleaning module during the entire detection process. The entire operation process, including the discarding process, is completed inside the integrated incubation and cleaning module, thereby realizing a new internal operation mode, greatly optimizing the overall structure and operation procedures of the immunoassay device and avoiding the occurrence of the problem of reaction cup contamination due to the external environment. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a schematic diagram of the three-dimensional structure of the integrated incubation and cleaning module in an embodiment of the present invention; Figure 2 This is a schematic diagram of the axial cross-sectional stereoscopic structure of the integrated incubation and cleaning module in an embodiment of the present invention; Figure 3This is a schematic diagram of the three-dimensional structure of the cleaning plate in an embodiment of the present invention; Figure 4 for Figure 3 A schematic diagram of a partial three-dimensional structure located at one part of the U-shaped groove; Figure 5 This is a schematic diagram of the three-dimensional structure of the incubation tray in an embodiment of the present invention; Figure 6 It is a schematic diagram of the three-dimensional structure of the integrated incubation and cleaning module after removing the cleaning tray in an embodiment of the present invention; Figure 7 for Figure 6 A schematic diagram of the local three-dimensional structure located at the second U-shaped groove; Figure 8 Schematic diagram of the three-dimensional structure of the internal transport mechanism of the reaction cup in an embodiment of the present invention; Fig. 9 It is a schematic diagram of a partial top view of the structure of the integrated incubation and cleaning module located at the U-shaped groove 1 of the cleaning tray and the U-shaped groove 2 of the incubation tray in an embodiment of the present invention; Fig.10 Schematic diagram of the principle of the adjustable support method of the incubation tray in an embodiment of the present invention; Fig.11 for Figure 6 The enlarged structural diagram of the middle C part; Fig.12 Schematic diagram of the principle structure of the internal transport method of the reaction cup in the embodiment of the present invention Figure 1 ; Fig.13 Schematic diagram of the principle structure of the internal transport method of the reaction cup in the embodiment of the present invention Figure 2 ; Fig.14 Schematic diagram of the principle structure of the internal transport method of the reaction cup in the embodiment of the present invention Figure 3 ; Fig.15 Schematic diagram of the principle structure of the internal transport method of the reaction cup in the embodiment of the present invention Figure 4 ; Fig.16 Schematic diagram of the principle structure of the internal transport method of the reaction cup in the embodiment of the present invention Figure 5 ; Fig.17 This is a schematic diagram of the main structure when the transfer tube lifts the reaction cup in an embodiment of the present invention; Fig.18 The three-dimensional structure of the transfer tube in the embodiment of the present invention is shown in FIG. Figure 1 ; Fig.19 The three-dimensional structure of the transfer tube in the embodiment of the present invention is shown in FIG. Figure 2 ; Fig. 20It is a schematic diagram of the three-dimensional structure of the cylinder in the transfer cylinder according to an embodiment of the present invention; Fig.21 for Figure 2 A schematic diagram of the enlarged structure of the middle part A; Fig. 22 Schematic diagram of the principle structure when discarding the reaction cup in an embodiment of the present invention Figure 1 ; Fig.23 Schematic diagram of the principle structure when discarding the reaction cup in an embodiment of the present invention Figure 2 ; Fig.24 Schematic diagram of the principle structure when discarding the reaction cup in an embodiment of the present invention Figure 3 .

[0022] In the figure: 1. outer shell, 2. support feet, 3. cleaning plate, 311. upper plate, 312. lower plate, 313. U-shaped groove 1, 3131. step part 1, 4. incubation plate, 411. upper ring body, 4111. outer teeth, 412. lower ring body, 413. U-shaped groove 2, 4131. step part 2, 414. ring body through hole, 5. driving mechanism 1, 6. driving mechanism 2, 611. transmission gear, 7. reaction cup, 711. reaction cup body, 712. flange, 811. support column 1, 812. support column 2, 813. support column 3, 814. swing arm, 815. swing arm waist hole, 816. horizontal guide wheel 2, 9. horizontal guide wheel 1, 911. guide groove, 10. internal transport of reaction cup Mechanism, 101. Connecting seat, 11. Transfer cylinder, 111. Inner cavity of transfer cylinder, 112. Outer frame, 113. Cylinder, 1131. Left half cylinder, 1132. Right half cylinder, 12. Stepper motor 1, 13. Screw rod 1, 14. Nut seat 1, 15. Stepper motor 2, 16. Screw rod 2, 17. Nut seat 2, 18. Support rod 1, 19. Support rod 2, 20. Support rod 3, 21. Support rod 4, 22. Spring 1, 23. Spring 2, 24. Guide rod 1, 25. Guide rod 2, 26. Guide rod 3, 27. Guide rod 4, 28. Guide wheel, 29. Guide groove 1, 30. Guide groove 2, 31. Frame waist hole 1, 32. Frame waist hole 2, 33. Opening and closing guide plate, 34. Roller, 35. Cup throwing guide slot. DETAILED DESCRIPTION

[0023] The technical solution of the present invention is further described in detail below in conjunction with the accompanying drawings and specific embodiments. Example

[0024] This application first describes the structure of the integrated incubation and cleaning module.

[0025] like Figure 1 and Figure 2As shown, an integrated incubation and cleaning module comprises a circular outer shell 1. In order to facilitate the support of the entire module, a plurality of legs 2 are further arranged at the bottom of the outer shell 1; a cleaning tray 3 and an incubation tray 4 rotatably arranged inside the outer shell 1, the incubation tray 4 is arranged in a ring shape, the cleaning tray 3 is located inside the ring-shaped incubation tray 4, and the cleaning tray 3 and the incubation tray 4 are arranged coaxially; a driving mechanism 1 5 and a driving mechanism 2 6, the driving mechanism 1 5 is a cleaning tray driving motor, which is arranged on the inner bottom surface of the outer shell 1, and its output shaft is connected to the cleaning tray 3 for driving the rotation of the cleaning tray, the driving mechanism 2 6 is an incubation tray driving motor, which is arranged on the outer shell 1, and a transmission gear 611 is arranged on its output shaft, which is connected to the incubation tray 4 through the transmission gear 611 for gear transmission, for driving the rotation of the incubation tray 4, and the specific gear transmission structure will be described in the subsequent content.

[0026] The structure of the cleaning plate 3 is described below: Figure 3 As shown, the cleaning tray 3 includes an upper tray body 311 and a lower tray body 312, and the upper tray body 311 is connected to the lower tray body 312 as a whole by screws and other connecting parts. The output shaft of the cleaning tray driving motor is connected to the center position of the lower tray body 312, so that the cleaning tray 3 can be driven to rotate under the drive of the cleaning tray driving motor. Along the circumference of the cleaning tray, a plurality of U-shaped grooves 313 for supporting reaction cups are arranged on the lower tray body 312, and the U-shaped grooves 313 are arranged radially toward the lower tray body 312. Figure 4 As shown, the reaction cup 7 includes a reaction cup body 711 and a flange 712 disposed on the reaction cup body 711, and the flange 712 is close to the opening position of the reaction cup body 711. When the reaction cup 7 is placed in the U-shaped groove 1 313, the flange 712 of the reaction cup 7 is placed on the bottom of the U-shaped groove 1 313, so as to support the reaction cup. In this embodiment, the bottom of the U-shaped groove 1 313 is an arc-shaped bottom, and a step portion 1 3131 is provided on the lower plate 312 and at the bottom of the U-shaped groove 1 313, and its curvature matches the curvature of the flange 712 of the reaction cup 7. When the reaction cup 7 is placed in the U-shaped groove 1 313, the flange 712 of the reaction cup 7 is placed on the step portion 1 3131 at the bottom of the U-shaped groove 1 313, so as to support the reaction cup. The flange 712 of the reaction cup 7 can be limited by the step portion 1 3131, so that the position of the reaction cup 7 on the cleaning plate can be positioned.

[0027] The structure of the incubation tray 4 is described below: Figures 5 to 7 As shown, the incubation tray 4 includes an upper ring body 411 and a lower ring body 412, and the upper ring body 411 is connected to the lower ring body 412 as a whole through connecting parts such as screws.

[0028] The outer circumferential surface of the upper ring body 411 is provided with external teeth 4111, and the external teeth 4111 are arranged in a full circle along the circumference of the upper ring body 411. The transmission gear 611 on the output shaft of the second drive mechanism 6 is meshed with the external teeth 4111 of the upper ring body 411, so that the incubation tray 4 can be driven to rotate through the second drive mechanism.

[0029] The structure of the incubation plate supporting the reaction cup is the same as the structure of the cleaning plate supporting the reaction cup. Figure 5 and Figure 7 As shown, along the circumference of the incubation tray, a plurality of U-shaped grooves 413 for supporting reaction cups are arranged on the lower ring body 412 of the incubation tray, and the U-shaped grooves 413 are arranged radially toward the lower ring body 412. When the incubation tray and the cleaning tray are assembled, the notches of the U-shaped grooves 413 and the notches of the U-shaped grooves 1 313 are arranged opposite to each other, that is, the notch direction of the U-shaped grooves 413 faces the notch direction of the U-shaped grooves 1 313, and through the rotation of the incubation tray and the cleaning tray, one of the U-shaped grooves 413 and one of the U-shaped grooves 1 313 can be located on the same radial line.

[0030] When the reaction cup 7 is placed in the second U-shaped groove 413, the flange 712 of the reaction cup 7 is placed on the bottom of the second U-shaped groove 413, so that the reaction cup is supported. In this embodiment, the bottom of the second U-shaped groove 413 is an arc-shaped bottom, and a second step portion 4131 is provided on the lower ring body 412 and at the bottom of the second U-shaped groove 413, and its curvature matches the curvature of the flange 712 of the reaction cup 7. When the reaction cup 7 is placed in the second U-shaped groove 413, the flange 712 of the reaction cup 7 is placed on the second step portion 4131 at the bottom of the second U-shaped groove 413, so that the reaction cup is supported. By providing the second step portion 4131, the flange 712 of the reaction cup 7 can be limited, so that the position of the reaction cup 7 on the incubation plate can be positioned.

[0031] In addition, it should be noted that before incubation and cleaning, in order to place the reaction cup into the integrated incubation and cleaning module, a ring body through hole 414 is opened on the upper ring body 411 and corresponding to each U-shaped groove 413. Before incubation and cleaning, the reaction cup is placed into the U-shaped groove 413 through the ring body through hole 414, thereby placing the reaction cup into the incubation tray, so that the reaction cup enters the integrated incubation and cleaning module.

[0032] like Figure 6 As shown, the integrated incubation and cleaning module in this embodiment further includes a reaction cup internal transport mechanism 10 disposed at the bottom of the outer shell 1, through which the reaction cup is transported back and forth between the cleaning tray 3 and the incubation tray 4. Figure 8As shown, the internal transport mechanism 10 of the reaction cup includes a connecting seat 101 connected to the bottom of the outer shell 1, an X-axis moving device arranged on the connecting seat 101 and a Z-axis moving device arranged on the X-axis moving device, and a transfer cylinder 11 is arranged on the Z-axis moving device. The X-axis moving device and the Z-axis moving device constitute a two-dimensional moving mechanism, the X-axis is arranged along the radial direction of the cleaning tray 3 and the incubation tray 4, and the Z-axis is perpendicular to the X-axis direction. Through the action of the two-dimensional moving mechanism, the transfer cylinder 11 is driven to move in the two-dimensional direction, and finally the reaction cup is transported back and forth between the cleaning tray 3 and the incubation tray 4 by using the transfer cylinder 11. In this embodiment, the X-axis moving device includes a stepper motor 12 arranged on the connecting seat 101 and a screw rod 13 rotatably connected to the connecting seat 101 through a bearing. The output shaft of the stepper motor 12 is transmission-connected with the screw rod 13 in cooperation. A nut seat 14 is also slidably connected to the connecting seat 101. The nut seat 14 is connected with the screw rod 13 in cooperation to form a screw rod and nut mechanism, so that under the action of the stepper motor 12, the nut seat 14 can be driven to move back and forth along the X-axis direction. The Y-axis moving device includes a stepper motor 15 disposed on the nut seat 14 and a screw 16 rotatably connected to the nut seat 14 through a bearing. The output shaft of the stepper motor 15 cooperates with the screw 16 for transmission connection. A nut seat 17 is also slidably connected to the nut seat 14. The nut seat 17 cooperates with the screw 16 to form a screw nut mechanism 2, so that the nut seat 17 can be driven to move up and down along the Y-axis under the action of the stepper motor 15. The transfer cylinder 11 is connected to the nut seat 17. It should be noted that the X-axis moving device and the Y-axis moving device can also adopt other structures as long as they can achieve two-dimensional movement in the X-axis direction and the Y-axis direction.

[0033] like Fig. 9 As shown, the transport method adopted in this embodiment is to use the transport cylinder 11 of the internal transport mechanism 10 of the reaction cup to drive the reaction cup 7 along the radial direction (i.e., the X-axis direction) of the cleaning tray 3 and the incubation tray 4, and move from the U-shaped groove 1 313 on the cleaning tray 3 to the U-shaped groove 2 413 of the incubation tray 4, or from the U-shaped groove 2 413 of the incubation tray 4 to the U-shaped groove 1 313 on the cleaning tray 3, thereby realizing the transport of the reaction cup between the cleaning tray 3 and the incubation tray 4.

[0034] from Fig. 9It can be seen that the method described in the present application for adapting to the movement of the internal transport mechanism of the reaction cup is because the internal transport mechanism of the reaction cup moves along the radial direction (i.e., the X-axis direction) of the cleaning tray 3 and the incubation tray 4. Therefore, it is required to ensure that when the incubation tray 4 is installed, through the rotation of the incubation tray and the cleaning tray, one of the U-shaped grooves 413 on the incubation tray 4 and one of the U-shaped grooves 313 on the cleaning tray 3 can be located on the same radial line B. In this way, it is ensured that the internal transport mechanism of the reaction cup drives the reaction cup 7 to move back and forth between the U-shaped groove 313 on the cleaning tray 3 and the U-shaped groove 413 on the incubation tray 4 to complete the transport work. However, the problem in reality is that when the middle cleaning tray 3 is installed, due to other reasons such as the manufacturing and processing of the incubation tray 4, the position of the incubation tray 4 after installation cannot meet the above requirements, so it needs to be adjusted.

[0035] like Figure 6 and Figure 7 As shown, the incubation tray 4 in this embodiment is arranged in a ring shape and is supported and connected to the inner bottom of the outer shell 1 by three or more horizontal guide wheels 9. Fig. 9 and Fig.10 As shown, the annular incubation tray 4 can actually be regarded as a circle, and each horizontal guide wheel 9 can be regarded as a point C. Since the three points C can determine the position of a circle, in order to adjust the position of the incubation tray 4, the applicant designs at least two of the horizontal guide wheels 9 as a fixed horizontal guide wheel structure (i.e., point C1) to keep their positions fixed, and designs at least one of the horizontal guide wheels 9 as a horizontal guide wheel structure with adjustable position (i.e., point C2). After the cleaning tray 3 is installed, the position of the annular incubation tray 4 is adjusted by adjusting the position of the adjustable horizontal guide wheel structure (i.e., point C2), thereby ensuring that during the working process, through the rotation of the incubation tray and the cleaning tray, one of the U-shaped grooves 413 on the incubation tray 4 and one of the U-shaped grooves 313 on the cleaning tray 3 can be located on the same radial line B to adapt to the action of the internal transport mechanism of the reaction cup. Therefore, in this embodiment, at least one horizontal guide wheel structure with adjustable position (i.e., point C2) and at least two horizontal guide wheel structures with fixed position (i.e., point C1) are designed.

[0036] like Figure 7 As shown, the fixed horizontal guide wheel structure includes a support column 811 arranged on the inner bottom of the outer shell 1 and a horizontal guide wheel 9 arranged on the top of the support column 811, and a guide groove 911 is opened on the circumferential surface of the horizontal guide wheel 9, and the guide groove 911 is arranged along the circumference of the horizontal guide wheel 9. A full circle is formed, and the inner peripheral part of the upper ring body 411 is inserted into the guide groove 911 of the horizontal guide wheel 9 and is connected with the guide groove 911 through transmission, so that the incubation tray 4 is rotatably arranged inside the outer shell 1.

[0037] like Fig.11 As shown, the position-adjustable horizontal guide wheel structure includes a second support column 812 and a third support column 813 arranged on the inner bottom of the outer shell 1, and a swing arm 814 is hinged on the top of the second support column 812, one end of the swing arm 814 is hinged on the top of the second support column 812, and a swing arm waist hole 815 is opened on the other end of the swing arm 814, and a screw 1 (not shown in the figure) is passed through the swing arm waist hole 815 and screwed into the top of the third support column 813, so that the other end of the swing arm 814 is locked on the top of the third support column 813, and a horizontal guide wheel 2 816 is arranged on the swing arm 814. A guide groove is also provided on the circumferential surface of the horizontal guide wheel 816, and the guide groove is arranged in a full circle along the circumference of the horizontal guide wheel 816. The inner circumference of the upper ring body 411 is inserted into the guide groove of the horizontal guide wheel 816 and is transmission-connected with the guide groove, so that the incubation tray 4 is rotatably arranged inside the outer shell 1.

[0038] The specific steps of the adjustable support method for the incubation tray in this embodiment are as follows: Figure 7 and Fig.11 As shown, the inner circumference of the upper ring body 411 of the incubation tray is inserted into the guide groove 911 of the horizontal guide wheel 1 9 of at least two fixed horizontal guide wheel structures and the guide groove of the horizontal guide wheel 2 816 of at least one adjustable horizontal guide wheel structure, and then the position of the swing arm 814 of at least one adjustable horizontal guide wheel structure is adjusted so that one of the U-shaped grooves 2 413 on the incubation tray 4 and one of the U-shaped grooves 1 313 on the cleaning tray 3 can be located on the same radial line B, and then the screw 1 is tightened to lock the swing arm 814, so that the incubation tray 4 is rotatably arranged inside the outer shell 1.

[0039] This embodiment sets one of the three connection points as a connection point with adjustable position, and determines the position of the annular incubation disk by the three adjusted connection points, thereby ensuring that after the incubation disk in the integrated incubation and cleaning module is installed, it can adapt to the movement of the internal transport mechanism of the reaction cup, realize the internal transport operation of the reaction cup, thereby changing the existing method of transporting the reaction cup from the outside, reducing the setting of external related components, reducing the overall volume of the immunoassay device, simplifying the overall structure of the immunoassay device, and reducing the overall cost of the immunoassay device.

[0040] The specific transport operation of the transport mechanism inside the reaction cup is described below: like Fig. 9As shown, when the reaction cup is transferred from the incubation tray 4 to the cleaning tray 3, the incubation tray 4 and the cleaning tray 3 are first controlled to rotate so that the notch of a U-shaped groove 413 on the incubation tray 4 and the notch of a U-shaped groove 313 on the cleaning tray 3 are aligned along the radial direction of the incubation tray 4 and the cleaning tray 3, and then the specific operation steps are: 1) If Fig.12 and Fig.13 As shown, the Y-axis moving device is controlled to move so that the transfer tube 11 moves upward, so that the transfer tube 11 contacts the reaction cup 7 located in the second U-shaped groove 413, and in the process of the transfer tube 11 continuing to move upward, the reaction cup 7 is lifted up from the second U-shaped groove 413, so that a vertical distance H1 is left between the flange 712 of the reaction cup and the notch plane of the second U-shaped groove 413, so as to avoid the reaction cup being hindered when moving radially; 2) If Fig.14 and Fig.15 As shown, the X-axis moving device is controlled to move so that the transfer cylinder 11 moves radially toward the cleaning plate 3, driving the reaction cup 7 to move out of the notch of the U-shaped groove 2 413, and then move into the notch of the U-shaped groove 1 313, until it moves to the upper position of the bottom of the U-shaped groove 1 313. At this time, the flange 712 of the reaction cup and the notch plane of the U-shaped groove 1 313 leave a vertical distance H2; 3) If Fig.16 As shown, the Y-axis moving device is controlled to move so that the transfer cylinder 11 moves downward, so that the flange 712 of the reaction cup is placed in the U-shaped groove 313, thereby placing the reaction cup 7 into the cleaning tray 3; when the transfer cylinder 11 moves down to the right position, the transfer cylinder 11 is separated from the reaction cup 7, which can ensure that the rotation of the tray will not be hindered during the subsequent detection process.

[0041] Conversely, when the reaction cup is transferred from the cleaning tray 3 to the incubation tray 4, the specific operation steps are exactly opposite to the above, namely: First, the incubation tray 4 and the cleaning tray 3 are controlled to rotate so that the notch of a U-shaped groove 413 on the incubation tray 4 and the notch of a U-shaped groove 313 on the cleaning tray 3 are aligned along the radial direction of the incubation tray 4 and the cleaning tray 3, and then the specific operation steps are: S1, control the Y-axis moving device to move the transfer tube 11 upward, so that the transfer tube 11 contacts the reaction cup 7 in the U-shaped groove 313 and in the process of the transfer tube 11 continuing to move upward, the reaction cup 7 is lifted out of the U-shaped groove 313, so that the flange 712 of the reaction cup and the notch plane of the U-shaped groove 313 leave a vertical distance H2, so as to avoid the reaction cup being hindered when moving radially; S2, control the X-axis moving device to move, so that the transfer cylinder 11 moves radially toward the incubation plate 4, driving the reaction cup 7 to move out of the notch of the U-shaped groove 1 313, and then move into the notch of the U-shaped groove 2 413, until it moves to the upper position of the bottom of the groove of the U-shaped groove 2 413, at this time, the flange 712 of the reaction cup and the notch plane of the U-shaped groove 2 413 leave a vertical distance H1; S3. Control the Y-axis moving device to move the transfer tube 11 downward, so that the flange 712 of the reaction cup is placed in the U-shaped groove 413, thereby placing the reaction cup 7 into the incubation tray 4; when the transfer tube 11 moves down to its proper position, the transfer tube 11 is separated from the reaction cup 7, so as to ensure that the rotation of the tray will not be hindered during the subsequent detection process.

[0042] Through the above-mentioned specific operation steps, the transfer operation of the reaction cup inside the integrated incubation and cleaning module is realized without the aid of an external manipulator. Under the premise of ensuring the normal transfer of the reaction cup, the existing method of transferring the reaction cup from the outside is changed, and the setting of external related components is reduced, thereby reducing the overall volume of the immunoassay device, simplifying the overall structure of the immunoassay device, and reducing the overall cost of the immunoassay device.

[0043] like Figure 4 and Fig.17 As shown, the cup body 711 of the reaction cup is a conical cylinder, the large end of which is located at the upper position (i.e., close to the flange 712), and the lower end of which is located at the lower position (i.e., away from the flange 712). Correspondingly, the transfer tube inner cavity 111 of the transfer tube 11 is also set to a conical shape with a large top and a small bottom, as shown in FIG. Fig.12 As shown, when the reaction cup is lifted up by the transfer tube 11, the conical surface of the transfer tube inner cavity 111 is used to cooperate with the conical surface of the reaction cup body 711 to lift up the reaction cup. When the taper of the conical surface of the transfer tube inner cavity 111 is designed to be different from the taper of the conical surface of the reaction cup body 711, the part where the conical surface of the transfer tube inner cavity 111 cooperates with the conical surface of the reaction cup body 711 is set as the contact part S, and the position of the contact part S is adjusted up and down by adjusting the taper of the conical surface of the transfer tube inner cavity 111 and the taper of the conical surface of the reaction cup body 711. In this way, when the position of the contact part S is different, it will actually lead to different parameters such as the stroke of the transfer tube upward movement, so as to adapt to various working conditions.

[0044] After the test is completed, the reaction cup needs to be discarded. The prior art also uses an external manipulator to take out and discard the reaction cup. In this case, it must also rely on the external manipulator to complete it, which also leads to too many external related components and increases the overall volume of the immunoassay device. Therefore, the applicant has made further improvements to the internal transport mechanism and related positions of the reaction cup, which are described as follows: like Figures 18 to 20 As shown, the transfer cylinder 11 includes an outer frame 112 and a cylinder 113 arranged inside the outer frame 112. The cylinder 113 is a two-half structure, including a left half cylinder 1131 and a right half cylinder 1132. A support rod 18 and a support rod 2 19 are respectively arranged on both sides of the left half cylinder 1131, and a support rod 3 20 and a support rod 4 21 are respectively arranged on both sides of the right half cylinder 1132. A spring 1 22 is arranged between the support rod 1 18 and the support rod 3 20. A spring 23 is arranged between the support rod 2 19 and the support rod 4 21. The spring 1 22 and the spring 23 are both tension springs. The left half cylinder 1131 and the right half cylinder 1132 are closed together to form the cylinder 113 by means of the spring 1 22 and the spring 23. A guide rod 1 24 and a guide rod 25 are respectively arranged on both sides of the left half cylinder 1131, and a guide rod 3 26 and a guide rod 4 27 are respectively arranged on both sides of the right half cylinder 1132. A guide wheel 28 is connected to each guide rod. A guide groove 1 29 and a guide groove 2 30 are respectively provided on the opposite side surfaces of the outer frame 112. When the closed cylinder 113 is placed in the outer frame 112, the guide wheels on the guide rods 1 24 and 3 26 cooperate with the guide groove 1 29, and the guide wheels on the guide rods 25 and 4 27 cooperate with the guide groove 2 30, thereby connecting the cylinder 113 to the outer frame 112. In this way, when the cylinder 113 is separated or closed, the guide wheels on the left half cylinder 1131 move along the guide groove 1 29 and the guide groove 2 30, and the guide wheels on the right half cylinder 1132 move along the guide groove 1 29 and the guide groove 2 30, so that the left half cylinder 1131 and the right half cylinder 1132 can be guided during the separation or closing process, thereby ensuring stability. In addition, a frame waist hole 31 and a frame waist hole 32 are respectively opened on the opposite side surfaces of the outer frame 112, one end of the support rod 18 and the support rod 3 20 extends out of the frame waist hole 31, and one end of the support rod 2 19 and the support rod 4 21 extends out of the frame waist hole 2 32, so that the support rods can be avoided and the overall volume of the transfer cylinder can be reduced.

[0045] like Fig.21 As shown, a conical opening and closing guide plate 33 is also provided on the inner bottom surface of the outer shell 1 located at the internal transfer mechanism 10 of the reaction cup. The opening and closing guide plate 33 is located below the transfer cylinder 11. Rollers 34 are provided on one end of the support rod 18 and the support rod 3 20. The opening and closing guide plate 33 cooperates with the roller 34 of the transfer cylinder 11, so that the left half cylinder 1131 and the right half cylinder 1132 of the transfer cylinder can be separated.

[0046] When testing is performed, the left half cylinder 1131 and the right half cylinder 1132 of the transfer cylinder are closed to form the cylinder 113, so that the inner cavity 111 of the transfer cylinder is used to drive the reaction cup 7 to move; when the test is completed, the left half cylinder 1131 and the right half cylinder 1132 of the transfer cylinder are separated by the cooperation of the transfer cylinder and the conical opening and closing guide plate, so that the reaction cup falls out of the left half cylinder 1131 and the right half cylinder 1132. When the reaction cup needs to be discarded, the transfer cylinder 11 is first controlled to move to the position between the cleaning tray 3 and the incubation tray 4, and then the specific operation steps are as follows: A1: Figure 22 to Figure 24 As shown, the Y-axis moving device is controlled to move so that the transfer cylinder 11 moves downward. During the downward movement, the roller 34 on the support rod 18 on the left semi-cylinder 1131 and the roller 34 on the support rod 3 20 on the right semi-cylinder 1132 respectively contact and roll with the conical surfaces on both sides of the conical opening and closing guide plate 33, so that the left semi-cylinder 1131 and the right semi-cylinder 1132 move away from each other, and the left semi-cylinder 1131 and the right semi-cylinder 1132 are separated. At this time, the spring 1 22 and the spring 23 are both in a stretched state. When separated, the reaction cup 7 in the transfer cylinder falls out. A2: Control the Y-axis moving device to move so that the transfer cylinder 11 moves upward. During the upward movement, the roller 34 on the support rod 18 on the left half cylinder 1131 and the roller 34 on the support rod 3 20 on the right half cylinder 1132 are respectively separated from the conical opening and closing guide plate 33. At this time, under the action of the restoring force of spring 1 22 and spring 23, the left half cylinder 1131 and the right half cylinder 1132 are moved relatively close to each other, and the left half cylinder 1131 and the right half cylinder 1132 are closed together again.

[0047] Through the above steps, the present embodiment can automatically discard the reaction cup after the detection is completed inside the integrated incubation and cleaning module, without the need to use an external robot to take out the reaction cup and then discard it, further reducing the setting of external related components, thereby further reducing the overall volume of the immunoassay device, simplifying the overall structure of the immunoassay device, and reducing the overall cost of the immunoassay device.

[0048] In addition, it should be noted that, through the overall design of this embodiment, after the reaction cup enters the integrated incubation and cleaning module, it no longer needs to repeatedly enter and exit the integrated incubation and cleaning module during the entire detection process. The entire operation process, including the discarding process, is completed inside the integrated incubation and cleaning module, thereby realizing a new internal operation mode, greatly optimizing the overall structure and operation procedures of the immunoassay device and avoiding the occurrence of reaction cup contamination due to the external environment.

[0049] like Fig.21As shown, a cup-dropping guide slot 35 is also provided on the outer shell 1 at the opening and closing guide plate 33, and the cup-dropping guide slot 35 is also located below the transfer cylinder 11. When the reaction cup 7 falls from the transfer cylinder 11, the reaction cup 7 falls into the cup-dropping guide slot 35, and is then guided out of the integrated incubation and cleaning module through the cup-dropping guide slot 35. This facilitates the guidance of the discarded reaction cup.

[0050] In summary, the present invention performs both the transportation and discarding of reaction cups from the inside of the integrated incubation and cleaning module, which changes the current external operation mode and reduces the setting of external related components, thereby minimizing the overall volume of the immunoassay device, simplifying the overall structure of the immunoassay device, and reducing the overall cost of the immunoassay device. Through the overall design of the present invention, after the reaction cup enters the integrated incubation and cleaning module, it is no longer necessary to repeatedly enter and exit the integrated incubation and cleaning module during the entire detection process. The entire operation process, including the discarding process, is completed within the integrated incubation and cleaning module, thereby realizing a new internal operation mode, greatly optimizing the overall structure and operation procedures of the immunoassay device and avoiding the occurrence of the problem of reaction cup contamination due to the external environment.

[0051] The above embodiments are only used to illustrate the present invention, rather than to limit the present invention. Technicians in the relevant technical field may make various changes or modifications without departing from the spirit and scope of the present invention. Therefore, all equivalent technical solutions should also fall within the protection scope of the present invention, and the protection scope of the present invention should be defined by the claims.

Claims

1. An integrated incubation and cleaning module of a fully automatic single-molecule immunoassay device, comprising an outer shell and a cleaning disk and an incubation disk rotatably connected to the inner portion of the outer shell, characterized in that: The incubation tray is annular, and the cleaning tray is located at the inner circumference of the annular incubation tray. An adjustable support structure is also provided inside the outer shell, and the annular incubation tray is rotatably connected to the inside of the outer shell through the adjustable support structure; an internal reaction cup transport mechanism is also provided on the outer shell, and the reaction cup is transported between the cleaning tray and the incubation tray inside the integrated incubation and cleaning module by means of the internal reaction cup transport mechanism, and the reaction cup after detection is discarded from the integrated incubation and cleaning module by means of the internal reaction cup transport mechanism.

2. The integrated incubation and cleaning module according to claim 1, characterized in that: The adjustable support structure includes at least two fixed horizontal guide wheel structures and at least one adjustable horizontal guide wheel structure arranged inside the outer shell. The at least two fixed horizontal guide wheel structures and at least one adjustable horizontal guide wheel structure are used to cooperate with the inner circumference of the annular incubation tray for transmission connection, so that the incubation tray is rotatably connected to the inside of the outer shell.

3. The integrated incubation and cleaning module according to claim 2, characterized in that: The fixed-position horizontal guide wheel structure includes a support column 1 and a horizontal guide wheel 1 arranged on the top of the support column 1, and a guide groove that cooperates with the annular incubation tray is opened on the circumferential surface of the horizontal guide wheel 1. The adjustable-position horizontal guide wheel structure includes a support column 2 and a support column 3. A swing arm is hinged on the top of the support column 2, one end of the swing arm is hinged on the top of the support column 2, and a swing arm waist hole is opened on the other end of the swing arm. A screw 1 is passed through the swing arm waist hole and screwed into the top of the support column 3, so that the other end of the swing arm is locked to the top of the support column 3. A horizontal guide wheel 2 is arranged on the swing arm, and a guide groove that cooperates with the annular incubation tray is also opened on the circumferential surface of the horizontal guide wheel 2.

4. The integrated incubation and cleaning module according to claim 3, characterized in that: The incubation tray comprises an upper ring body and a lower ring body, and the upper ring body and the lower ring body are connected as a whole; by inserting the inner circumference of the upper ring body into the guide groove of the horizontal guide wheel one and the guide groove of the horizontal guide wheel two, the incubation tray is rotatably connected to the inside of the outer shell.

5. The integrated incubation and cleaning module according to claim 4, characterized in that: External teeth are arranged on the outer peripheral surface of the upper ring body; a second driving mechanism is arranged on the outer shell, and a transmission gear is arranged on the output shaft of the second driving mechanism, which is meshed and connected with the external teeth of the upper ring body through the transmission gear, so that the incubation plate can be driven to rotate through the second driving mechanism.

6. The integrated incubation and cleaning module according to claim 4, characterized in that: The cleaning disc comprises an upper disc body and a lower disc body, and the upper disc body and the lower disc body are connected as a whole; a driving mechanism 1 is arranged on the outer shell, and the output shaft of the driving mechanism 1 is matched and connected with the center position of the lower disc body, so that the cleaning disc can be driven to rotate under the drive of the driving mechanism 1.

7. The integrated incubation and cleaning module according to claim 6, characterized in that: Along the circumference of the cleaning plate, a plurality of U-shaped grooves 1 for supporting reaction cups are arranged on the lower plate body, and the U-shaped grooves 1 are arranged radially toward the lower plate body; along the circumference of the incubation plate, a plurality of U-shaped grooves 2 for supporting reaction cups are arranged on the lower ring body of the incubation plate, and the U-shaped grooves 2 are arranged radially toward the lower ring body; When the reaction cup is transported between the cleaning tray and the incubation tray by using the internal transport mechanism of the reaction cup, a U-shaped groove 1 of the cleaning tray and a U-shaped groove 2 of the incubation tray are located on the same radial line.

8. The integrated incubation and cleaning module according to any one of claims 1 to 7, characterized in that: The internal transport mechanism of the reaction cup includes a connecting seat arranged on the outer shell, an X-axis moving device arranged on the connecting seat and a Z-axis moving device arranged on the X-axis moving device, a transport cylinder is arranged on the Z-axis moving device, and the X-axis moving device and the Z-axis moving device constitute a two-dimensional moving mechanism, and the X-axis is arranged along the radial direction of the cleaning tray and the incubation tray in the integrated incubation and cleaning module.

9. The integrated incubation and cleaning module according to claim 8, characterized in that: The X-axis moving device includes a motor 1 arranged on the connecting seat and a screw rod 1 rotatably connected to the connecting seat through a bearing, the output shaft of the motor 1 is connected to the screw rod 1 in a transmission cooperation, and a nut seat 1 is also slidably connected to the connecting seat, the nut seat 1 is connected to the screw rod 1 in a cooperation manner to form a screw rod and nut mechanism 1, so that under the action of the motor 1, the nut seat 1 can be driven to move back and forth along the X-axis direction; the Y-axis moving device includes a motor 2 arranged on the nut seat 1 and a screw rod 2 rotatably connected to the nut seat 1 through a bearing, the output shaft of the stepper motor 2 is connected to the screw rod 2 in a transmission cooperation manner, and a nut seat 2 is also slidably connected to the nut seat 1, the nut seat 2 is connected to the screw rod 2 in a cooperation manner to form a screw rod and nut mechanism 2, so that under the action of the motor 2, the nut seat 2 can be driven to move up and down along the Y-axis direction; the transfer cylinder is connected to the nut seat 2.

10. The integrated incubation and cleaning module according to claim 8, characterized in that: The transfer cylinder comprises an outer frame and a cylinder body arranged inside the outer frame, the cylinder body is a two-half structure, including a left half cylinder body and a right half cylinder body, support rod 1 and support rod 2 are respectively arranged on both sides of the left half cylinder body, support rod 3 and support rod 4 are respectively arranged on both sides of the right half cylinder body, spring 1 is arranged between the support rod 1 and the support rod 3, spring 2 is arranged between the support rod 2 and the support rod 4, the left half cylinder body and the right half cylinder body are closed together to form the cylinder body by spring 1 and spring 2, guide rod 1 and guide rod 2 are also respectively arranged on both sides of the left half cylinder body, guide rod 3 and guide rod 4 are respectively arranged on both sides of the right half cylinder body, and guide wheels are connected to each guide rod; A guide groove 1 and a guide groove 2 are respectively formed on two opposite side surfaces of the outer frame. When the cylinder body that is put together is placed in the outer frame, the guide wheels on the guide rods 1 and 3 cooperate with the guide groove 1, and the guide wheels on the guide rods 2 and 4 cooperate with the guide groove 2, so that the cylinder body is connected to the outer frame. A frame waist hole 1 and a frame waist hole 2 are also respectively formed on two opposite side surfaces of the outer frame. One end of the support rod 1 and the support rod 3 extends out of the frame waist hole 1, and one end of the support rod 2 and the support rod 4 extends out of the frame waist hole 2. A conical opening and closing guide plate is also provided on the bottom of the integrated incubation and cleaning module, and the opening and closing guide plate is located below the transfer cylinder. Rollers are provided on one end of the support rod one and the support rod three. The opening and closing guide plate cooperates with the roller of the transfer cylinder to separate the left half cylinder and the right half cylinder of the transfer cylinder.

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