Emulsifier-free high-content pure natural source grease cream and preparation method thereof

Abstract

The invention discloses an emulsifier-free high-content pure natural source grease cream and a preparation method thereof, and belongs to the technical field of cosmetics. The cream is prepared from raw materials in percentage by mass as follows: 30%-40% of an emollient, 5%-10% of a humectant, 0.5%-5% of a thickener, 0.01%-0.2% of a chelating agent, 0.01%-0.5% of a pH regulator, 0.6%-1% of a preservative and the balance of water. The emollient is grease from pure natural sources; the mass ratio of the acrylic acid (ester) / C10-30 alkanol acrylate cross-linked polymer in the thickening agent to the pH regulator is 1: 0.9 to 1: 1.1. The cream has the characteristics of no emulsifier, low preservative content and high grease content, is mild and non-irritant, has good stability and antibacterial effect, and can meet the requirements of cosmetics. The preparation method is simple, easy to operate and suitable for industrial production.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetics, and in particular to an emulsifier-free, high-content, pure natural oil cream and a preparation method thereof. Background Art

[0002] Emulsifier is an ingredient used to stabilize oils and fats, especially for cosmetics with high oil content. Emulsifiers can be used to enhance their stability and avoid stratification, oiling, demulsification, etc. However, in cosmetics with high oil content, it is often necessary to use emulsifiers with strong emulsification ability or increase the amount of emulsifier to make the corresponding cosmetics have better stability. Correspondingly, emulsifiers with strong emulsification ability or high dosage will cause irritation to the skin, especially the skin of sensitive people. For example, polyether emulsifiers, although polyether emulsifiers often have strong emulsification properties, they will inevitably bring in the risk ingredient dioxin during the raw material production process, which will affect the mildness of the product.

[0003] Preservatives are the second leading cause of cosmetic allergies and contact dermatitis after fragrances. Preservatives in cosmetics can inhibit the growth of microorganisms in cosmetics. Nowadays, influenced by the development of the market environment, more and more products have the requirement of "no added preservatives" (or "alternative preservatives", for the sake of unification, collectively referred to as "no added preservatives"). "No added preservatives" is not a requirement and meaning stipulated by regulations, but a market-oriented term, usually referring to the product without the addition of 51 permitted preservatives specified in the "Technical Specifications for Safety of Cosmetics (2015 Edition)".

[0004] At present, there is no cream-type cosmetic that has both good stability and antibacterial effect under the premise of high fat content, no emulsifier, and low preservative content.

[0005] In view of this, the present invention is proposed. Summary of the invention

[0006] The object of the present invention is to provide an emulsifier-free, high-content, pure natural oil cream and a preparation method thereof, so as to solve or improve the above technical problems.

[0007] The present invention can be implemented like this:

[0008] In a first aspect, the present invention provides an emulsifier-free high-content pure natural source oil cream, wherein the raw materials for preparing the high-content pure natural source oil cream include, by mass percentage, 30% to 40% of an emollient, 5% to 10% of a moisturizer, 0.5% to 5% of a thickener, 0.01% to 0.2% of a chelating agent, 0.01% to 0.5% of a pH regulator, and 0.6% to 1% of a preservative, with the remainder being water;

[0009] Emollients are oils of pure natural origin;

[0010] The thickener includes acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, and the mass ratio of acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer in the thickener to the pH adjuster is 1:0.9 to 1:1.1.

[0011] In an optional embodiment, the raw materials for preparing the high-content pure natural source oil cream include, by mass percentage, 32% to 38% of emollients, 6% to 8% of humectants, 2% to 3% of thickeners, 0.01% to 0.1% of chelating agents, 0.2% to 0.4% of pH adjusters and 0.6% to 0.8% of preservatives, with the balance being water.

[0012] In an optional embodiment, the raw materials for preparing the high-content pure natural source oil cream include, by mass percentage, 35% emollient, 7.1% humectant, 2.3% thickener, 0.05% chelating agent, 0.3% pH adjuster and 0.6% preservative, with the balance being water.

[0013] In an alternative embodiment, the emollient includes at least one of squalane, coco-caprylate / caprate, jojoba seed oil, and meadowfoam seed oil.

[0014] In an alternative embodiment, the moisturizer includes at least one of glycerin, 1,3-butylene glycol, hyaluronic acid, and hydrogenated lecithin.

[0015] In an optional embodiment, the thickener further includes at least one of carbomer and cetearyl alcohol.

[0016] In an alternative embodiment, the chelating agent comprises EDTA-2Na.

[0017] In an alternative embodiment, the pH adjuster includes at least one of sodium hydroxide, aminomethyl propanol and arginine.

[0018] In an alternative embodiment, the preservative comprises at least one of p-hydroxyacetophenone and 1,2-hexanediol.

[0019] In a second aspect, the present invention provides a method for preparing a high-content pure natural source oil cream as described in any of the aforementioned embodiments, comprising the following steps: mixing water, a moisturizer and a chelating agent according to a proportion and heating the mixture to obtain a first mixture; mixing an emollient and a thickener and heating the mixture to obtain a second mixture; mixing the first mixture and the second mixture to obtain a third mixture; and first adding a pH adjuster and then a preservative to the third mixture.

[0020] The beneficial effects of the present invention include:

[0021] The cream provided by the present invention has the characteristics of being free of emulsifier, low in preservative content (the amount of preservatives used in existing conventional cosmetics can be reduced by about 40%), and high in fat content (the amount of fat used in existing conventional cosmetics is increased from 5% to 25% to 30% to 40%). In addition, the cream is mild and non-irritating, has good stability and antibacterial effects, and can meet the requirements of cosmetics. DETAILED DESCRIPTION

[0022] In order to make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme in the embodiments of the present invention will be described clearly and completely below. If the specific conditions are not specified in the embodiments, they are carried out according to conventional conditions or conditions recommended by the manufacturer. If the manufacturer of the reagents or instruments used is not specified, they are all conventional products that can be purchased commercially.

[0023] The emulsifier-free, high-content, pure natural oil cream and its preparation method provided by the present invention are specifically described below.

[0024] The invention provides an emulsifier-free high-content pure natural source oil cream. Calculated by mass percentage, the raw materials for preparing the high-content pure natural source oil cream include 30% to 40% of emollient, 5% to 10% of moisturizer, 0.5% to 5% of thickener, 0.01% to 0.2% of chelating agent, 0.01% to 0.5% of pH regulator and 0.6% to 1% of preservative, and the balance is water.

[0025] Among them, emollients can have a moisturizing and hydrating effect. Currently, mineral oils and synthetic oils are more commonly used in cosmetics. The above types of oils are relatively low in cost, but they have a certain impact on the mildness of the product. For example, mineral oils are derived from petroleum and contain impurities that may have adverse effects on the skin; the by-products in synthetic oils are often prone to irritation.

[0026] The emollient used in the present invention is a pure natural oil, which can include, by way of example but not limitation, at least one of squalane, coconut oil alcohol-caprylate / caprate, jojoba seed oil and meadowfoam seed oil. By using the above pure natural oil, the skin can have better skin affinity and mildness.

[0027] Among them, squalane can be derived from olives. Squalane can strengthen the repair of the epidermis, effectively form a natural protective film, help balance the skin and sebum, have strong affinity, and can integrate with the human body's own sebum film to form a natural barrier on the skin surface.

[0028] Coco-Caprylate / Caprate is a 100% natural plant-derived oil derived from coconut, which can improve skin softness.

[0029] Jojoba seed oil is a natural green vegetable oil obtained from the seeds of a desert shrub (jojoba) that can be used to protect and lubricate the skin.

[0030] Meadowfoam seed oil is 100% derived from the natural plant meadowfoam, has excellent emollient properties, and can improve the skin's barrier function.

[0031] In some optional embodiments, the amount of emollient can be 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39% or 40%, etc., or other values ​​within the range of 30% to 40%.

[0032] It should be noted that the maximum amount of oil in common cream cosmetics is about 25%. When the amount of oil is too high, a very high amount of emulsifier is required to stabilize it, which will increase the irritation of the emulsifier to the skin and increase the burden on the skin. The present invention breaks the conventional setting and, by combining the use of other preparation raw materials in this application, ensures that the product is basically non-irritating to the skin when the oil content is increased to 30% to 40%.

[0033] In some optional embodiments, the amount of the moisturizer can be 5%, 5.5%, 6%, 6.5%, 7%, 7.5%, 8%, 8.5%, 9%, 9.5% or 10%, etc., or other values ​​within the range of 5% to 10%.

[0034] The moisturizer may illustratively but not limitatively include at least one of glycerin, 1,3-butylene glycol, hyaluronic acid, and hydrogenated lecithin.

[0035] In some optional embodiments, the amount of thickener can be 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5% or 5%, etc., or other values ​​within the range of 0.5% to 5%.

[0036] The thickener includes acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, and on this basis, it can also include at least one of carbomer and cetearyl alcohol.

[0037] In some optional embodiments, the amount of the chelating agent can be 0.01%, 0.02%, 0.04%, 0.06%, 0.08%, 0.1%, 0.12%, 0.14%, 0.16%, 0.18% or 0.2%, etc., or other values ​​within the range of 0.01% to 0.2%.

[0038] The chelating agent may illustratively but not limitedly include EDTA-2Na.

[0039] In some optional embodiments, the dosage of the pH adjuster can be 0.01%, 0.05%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45% or 0.5%, etc., or other values ​​within the range of 0.01% to 0.5%.

[0040] The pH adjuster may illustratively but not limitatively include at least one of sodium hydroxide, aminomethyl propanol, and arginine.

[0041] In some optional embodiments, the amount of preservatives used can be 1%, 0.9%, 0.8%, 0.7% or 0.6%, etc.

[0042] The preservative may illustratively but not limitatively include at least one of p-hydroxyacetophenone and 1,2-hexanediol.

[0043] Among them, 1,2-hexanediol is a polyol, which is colorless and transparent in appearance and has good bactericidal and moisturizing effects. Para-hydroxyacetophenone is a natural ingredient extracted from plants such as Artemisia capillaris, which has good water solubility and good antioxidant and antibacterial properties.

[0044] In some preferred embodiments, the raw materials for preparing the high-content pure natural oil cream include, by mass percentage, 32% to 38% of emollients, 6% to 8% of humectants, 2% to 3% of thickeners, 0.01% to 0.1% of chelating agents, 0.2% to 0.4% of pH adjusters and 0.6% to 0.8% of preservatives, with the balance being water.

[0045] In some typical embodiments, the mass ratio of acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer in the thickener to the pH adjuster is 1:0.9 to 1:1.1, preferably 1:1.

[0046] In some more preferred embodiments, the raw materials for preparing the high-content pure natural source oil cream include, by mass percentage, 35% of an emollient (consisting of 10% squalane, 10% coconut oil caprylate / caprate, 10% jojoba seed oil, and 5% white meadowfoam seed oil), 7.1% of a moisturizer (consisting of 6% glycerin, 0.1% hyaluronic acid, and 1% hydrogenated lecithin), 2.3% of a thickener (consisting of 0.3% acrylic acid (ester) / C10-30 alkyl acrylate crosspolymer and 2% cetearyl alcohol), 0.05% of a chelating agent (EDTA-2Na), 0.3% of a pH adjuster (arginine), and 0.6% of a preservative (consisting of 0.3% 1,2-hexanediol and 0.3% p-hydroxyacetophenone), and the balance is water. The cream obtained under the more optimal conditions has better stability and antibacterial properties, and the product performance is mild and non-irritating.

[0047] It should be noted that the current mainstream commonly used preservative system compounding ingredients are 1,2-hexanediol compounded with p-hydroxyacetophenone, and the conventional addition amounts of the two are 0.5% and 0.5% respectively, in order to obtain a preservative effect that can meet the requirements of cosmetics. The present invention can creatively reduce the amount of preservatives (such as the amount of preservatives is 0.6%, which can be reduced by 40% compared with the existing mainstream 0.5% 1,2-hexanediol and 0.5% p-hydroxyacetophenone compounded preservatives) by coordinating other preparation raw materials, while still enabling the corresponding products to meet the requirements of cosmetics in terms of preservative properties.

[0048] The reasons include:

[0049] ①. The factors that affect the ability of preservatives are not only directly related to the amount of preservatives added, but also other factors, such as pH value, water activity, activity of preservatives, oil-water partition ratio, etc. In the present invention, the main focus is on improving the anti-corrosion efficiency from the perspective of water activity and oil-water partition ratio, so that when the amount of preservatives added is reduced or not added, there is still a good anti-corrosion effect.

[0050] Specifically, in terms of water activity: not all water can be used for microbial growth. Only free water is an indispensable component for microbial growth and metabolism. The lower the water activity, the less conducive it is to microbial growth. Under the formula of the present invention, the high content of oil phase reduces the water activity and improves the preservative efficiency, which explains why there is still a certain preservative effect when no preservatives are added.

[0051] In terms of oil-water distribution ratio: in facial cream cosmetics, there are both oil phase and water phase, and the preservatives present in the water layer or interface directly affect the antiseptic ability of the product. For the same dose of preservatives, only when the preservative distribution ratio in water is higher, the antiseptic effect is better. In the present invention, on the one hand, the oil content is very high, that is, the water content is low, and on the other hand, the selected preservative is water-soluble, so that the concentration of the preservative in the water layer is higher, which improves the antiseptic performance, and explains why the antiseptic effect is still good when the amount of preservative is reduced.

[0052] ② In conventional cream products, emulsifiers need to be added to stabilize the oil phase in the formula. In the present invention, the thickener used not only provides thickening performance, but also has very low surface activity, can stabilize the water-in-oil system, and has strong suspension power, further ensuring the stability of the formula system.

[0053] ③. The present invention increases the amount of oil used while not using a high amount of emulsifier, thus avoiding the adverse effects of a high amount of emulsifier. On the other hand, the oil used is pure natural oil, which is safe and mild, and avoids the burden on the skin caused by mineral oil and synthetic oil at a high dosage.

[0054] In line with the above, the cream has the characteristics of being emulsifier-free, low in preservatives (can be reduced by about 40%), and high in oil content (increased from 5% to 25% to 30% to 40%). In addition, the cream is mild and non-irritating, has good stability and antibacterial effects, and can meet the requirements of cosmetics.

[0055] Correspondingly, the present invention also provides a method for preparing the above-mentioned emulsifier-free high-content pure natural source oil cream, comprising the following steps: mixing water, a moisturizer and a chelating agent according to a proportion and heating the mixture to obtain a first mixture; mixing an emollient and a thickener and heating the mixture to obtain a second mixture; mixing the first mixture and the second mixture to obtain a third mixture; and first adding a pH adjuster and then a preservative to the third mixture.

[0056] Specifically, water, moisturizer and chelating agent can be added to a water phase pot according to a ratio, and heated to 75°C to 85°C (such as 75°C, 78°C, 80°C, 82°C or 85°C, etc.) to obtain a first mixture (water phase); an emollient and a thickener are added to an oil phase pot, and heated to 75°C to 85°C (such as 75°C, 78°C, 80°C, 82°C or 85°C, etc.) to obtain a second mixture (oil phase); the first mixture and the second mixture are heated in an emulsifying pot at 3000r / min to 5000r / min. min and homogenize for 3min to 10min (such as 3min, 5min, 8min or 10min, etc.) to obtain a third mixture; add a pH adjuster to the third mixture, stir and homogenize, start cooling, stir and cool to 45°C to 55°C (such as 45°C, 48°C, 50°C, 52°C or 55°C, etc.), then add a preservative, stir and homogenize, stir and cool to 36°C to 40°C (such as 36°C, 37°C, 38°C, 39°C or 40°C, etc.), stop stirring and discharge.

[0057] As mentioned above, the preparation method of the high-content pure natural oil cream without emulsifier provided by the present invention is simple, easy to operate, and can be industrially produced.

[0058] The features and performance of the present invention are further described in detail below in conjunction with the embodiments.

[0059] The following examples and comparative examples all provide a cream, and the sources of some of the raw materials used are as follows:

[0060] Squalane: Laibaokang Daily Chemical (Shanghai) Co., Ltd., trade name: OLIVE SQUALANE.

[0061] Coconut oil-caprylate / caprate: BASF, trade name: C 5C.

[0062] Jojoba seed oil: Jojoba Company Inc., trade name: INCA JOJOBALITE.

[0063] Meadowfoam seed oil: NATURAL PLANT PRODUCT, trade name: MEADOWFOAM SEED OIL XPR.

[0064] 1,2-Hexanediol: Osaka Organic Chemical, Japan, trade name: KMO-6.

[0065] Parahydroxyacetophenone: Symsave Flavors & Fragrances (Nantong) Co., Ltd., trade name: SYMSAVE H.

[0066] The features and performance of the present invention are further described in detail below in conjunction with the embodiments.

[0067] Examples 1 to 3 and Comparative Examples 1 to 14:

[0068] The composition ratios of the formulations of Examples 1 to 3 and Comparative Examples 1 to 11 are shown in Tables 1 to 3.

[0069] The difference between Comparative Example 12 and Example 3 is that the grease used is mineral grease (specifically purchased from Zhejiang Zhengxin Petroleum Technology Co., Ltd., name: No. 26 cosmetic grade white oil).

[0070] The difference between Comparative Example 13 and Example 3 is that the grease used is synthetic grease (purchased from Dow (Zhangjiagang) Investment Co., Ltd., name: XIAMETER TM PMX-200Silicone Fluid 350cSt).

[0071] The difference between Comparative Example 14 and Example 3 is that the preservative consists of 0.3% of 1,2-pentanediol and 0.3% of p-hydroxyacetophenone.

[0072] The creams provided in Examples 1 to 3 and Comparative Examples 1 to 14 are all prepared according to the method: water, moisturizer and chelating agent are added to the water phase pot according to the ratio, and heated to 80°C to obtain a first mixture (water phase); an emollient and a thickener are added to the oil phase pot, and heated to 80°C to obtain a second mixture (oil phase); the first mixture and the second mixture are homogenized in an emulsifying pot at a speed of 4000r / min for 5min to obtain a third mixture; a pH adjuster is added to the third mixture, stirred and homogenized, cooling is started, stirring and cooling to 50°C, a preservative is added, stirred and homogenized, stirring and cooling to 38°C, stirring is stopped and the material is discharged.

[0073] The difference between Comparative Example 15 and Example 3 is that the third mixture is mixed with the pH adjuster and the preservative at the same time.

[0074] Table 1 Composition of Examples 1 to 3

[0075]

[0076] Table 2 Composition of Comparative Examples 1 to 6

[0077]

[0078]

[0079] Table 3 Composition of Comparative Examples 7 to 11

[0080]

[0081] Test Example 1

[0082] Stability test

[0083] The creams prepared in the above Examples 1 to 3 and Comparative Examples 1 to 15 were subjected to stability tests respectively.

[0084] The experimental methods and conditions refer to the relevant contents in "QB / T 1857 Moisturizing Creams".

[0085] The experimental results are shown in Tables 4 to 7.

[0086] Table 4 Stability test items

[0087]

[0088] Table 5 Stability test items

[0089]

[0090] Table 6 Stability test items

[0091]

[0092] Table 7 Stability test items

[0093]

[0094]

[0095] It can be seen from Tables 4 to 7 that the creams provided by Examples 1 to 3 of the present invention have good stability.

[0096] Test Example 2

[0097] Corrosion resistance test

[0098] Among the creams prepared from the above-mentioned Examples 1 to 3 and Comparative Examples 1 to 15, Examples 1 to 3 and Comparative Examples 1, 6, 7 and 14 that passed the stability test were subjected to antiseptic tests respectively.

[0099] The detection methods and judgment standards are all based on (T / GDCDC010-2019 Cosmetic Preservative Challenge Test Method). The initial microbial content determination and preservation test are carried out according to the above method, and two rounds of tests are carried out to observe the results for 3 days, 7 days, 14 days, 21 days, and 28 days.

[0100] The specific conditions of the microorganisms used in the antiseptic test are shown in Table 8. All bacteria and fungi are provided by the American Type Culture Collection (ATCC).

[0101] The inoculum size in the following table refers to the total inoculum size of bacteria or fungi, among which the inoculum ratio of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Burkholderia cepacia is 1:1:1:1, and the inoculum ratio of Candida albicans and Aspergillus brasiliensis is 1:1.

[0102] Table 8 Microorganisms for corrosion test

[0103]

[0104] The experimental results are shown in Tables 9 and 10.

[0105] Table 9 Anticorrosion test results (bacteria)

[0106] Inoculation amount, Day0 Day 3 Day 7 Day 14 Day 21 Day 28 Example 1 <![CDATA[4.2×10 6 ]]> ＜10 ＜10 ＜10 ＜10 ＜10 Example 2 <![CDATA[4.2×10 6 ]]> ＜10 ＜10 ＜10 ＜10 ＜10 Example 3 <![CDATA[4.2×10 6 ]]> <![CDATA[1.5×10 2 ]]> ＜10 ＜10 ＜10 ＜10 Comparative Example 1 <![CDATA[4.4×10 6 ]]> <![CDATA[>3.0×10 5 ]]> <![CDATA[5.5×10 4 ]]> <![CDATA[4.4×10 3 ]]> <![CDATA[3.2×10 2 ]]> <![CDATA[2.0×10 1 ]]> Comparative Example 6 <![CDATA[3.6×10 6 ]]> ＜10 ＜10 ＜10 ＜10 ＜10 Comparative Example 9 <![CDATA[4.4×10 6 ]]> <![CDATA[2.5×10 2 ]]> <![CDATA[5.0×10 1 ]]> ＜10 ＜10 ＜10 Comparative Example 14 <![CDATA[4.2×10 6 ]]> <![CDATA[7.5×10 4 ]]> <![CDATA[3.2×10 3 ]]> <![CDATA[2.0×10 2 ]]> ＜10 ＜10

[0107] Table 10 Anticorrosion test results (fungus)

[0108] Inoculation amount, Day0 Day 3 Day 7 Day 14 Day 21 Day 28 Example 1 <![CDATA[1.0×10 5 ]]> <![CDATA[1.0×10 1 ]]> ＜10 ＜10 ＜10 ＜10 Example 2 <![CDATA[1.0×10 5 ]]> <![CDATA[2.0×10 2 ]]> <![CDATA[3.0×10 1 ]]> ＜10 ＜10 ＜10 Example 3 <![CDATA[1.0×10 5 ]]> <![CDATA[3.0×10 2 ]]> <![CDATA[7.0×10 1 ]]> ＜10 ＜10 ＜10 Comparative Example 1 <![CDATA[1.0×10 5 ]]> <![CDATA[2.1×10 4 ]]> <![CDATA[7.0×10 3 ]]> <![CDATA[1.9×10 2 ]]> ＜10 ＜10 Comparative Example 6 <![CDATA[8.5×10 4 ]]> <![CDATA[3.9×10 4 ]]> <![CDATA[4.3×10 3 ]]> <![CDATA[2.1×10 2 ]]> <![CDATA[2.0×10 1 ]]> ＜10 Comparative Example 7 <![CDATA[1.0×10 5 ]]> <![CDATA[3.0×10 4 ]]> <![CDATA[3.5×10 3 ]]> <![CDATA[1.5×10 2 ]]> ＜10 ＜10 Comparative Example 14 <![CDATA[1.2×10 5 ]]> <![CDATA[2.5×10 4 ]]> <![CDATA[3.7×10 3 ]]> <![CDATA[2.4×10 2 ]]> ＜10 ＜10

[0109] It can be seen from Tables 9 and 10 that:

[0110] Take Examples 1 to 3 as examples:

[0111] The logarithmic value of bacteria reduction in 7 days is greater than 4, and the logarithmic value of fungi reduction in 28 days is greater than 6; the logarithmic value of fungi reduction in 7 days is greater than 2, and the logarithmic value of fungi reduction in 28 days is greater than 4. Judgment result: bacteria and fungi can pass the test.

[0112] Take Comparative Example 6, Comparative Example 7, and Comparative Example 14 as examples:

[0113] The logarithmic value of bacteria reduction in 7 days is greater than 4, and the logarithmic value of fungi reduction in 28 days is greater than 6; the logarithmic value of fungi reduction in 7 days is greater than 1, and the logarithmic value of fungi reduction in 28 days is greater than 4. Judgment result: bacteria can pass the test, but fungi cannot pass the test. Take comparative example 1 as an example:

[0114] The logarithmic value of bacteria decrease in 7 days is <2, and the logarithmic value decrease in 28 days is >4; the logarithmic value of fungi decrease in 7 days is >1, and the logarithmic value decrease in 28 days is >4.

[0115] Judgment result: Both bacteria and fungi cannot pass the test.

[0116] Similarly, the anti-corrosion test results of each embodiment and comparative example are summarized as shown in Table 11.

[0117] Table 11 Summary of anti-corrosion test results

[0118] Bacteria test Fungal test Example 1 pass pass Example 2 pass pass Example 3 pass pass Comparative Example 1 Not passed Not passed Comparative Example 6 pass Not passed Comparative Example 7 pass Not passed Comparative Example 14 pass Not passed

[0119] It can be seen from Tables 9 to 11 that the creams provided by the embodiments of the present invention have good antiseptic effects, among which the effect of Embodiment 3 is the best. The antiseptic system of Embodiment 3 is the minimum amount of antiseptic ingredients required to achieve a qualified antiseptic effect.

[0120] Test Example 3

[0121] Example 3, which performed best in Test Examples 1 and 2, was subjected to safety tests, including multiple (acute) skin irritation tests and eye irritation tests.

[0122] Multiple (acute) skin irritation test:

[0123] Test method: Refer to the 2015 edition of CFDA "Technical Specifications for Safety of Cosmetics";

[0124] Test animals: guinea pigs (female / male) weight: 250g~300g;

[0125] The experimental animal use license number of our hospital is SYXK(Shanghai)2024-0029;

[0126] Shanghai Jiagan Biotechnology Co., Ltd. Production License No.: SCXK (Shanghai) 2020-0006;

[0127] Test conditions: laboratory temperature is 20℃~24℃; relative humidity is 60%~70%;

[0128] The test results are shown in Table 12.

[0129] Table 12 Test results

[0130]

[0131]

[0132] Eye irritation test:

[0133] Test method: Refer to the 2015 edition of CFDA "Technical Specifications for Safety of Cosmetics";

[0134] Experimental animals: Rabbits (male / female). The license number of our hospital for experimental animals is SXK (Shanghai) 2024-0029; the production license number of Shanghai Jiagan Biotechnology Co., Ltd. is SCXK (Shanghai) 2020-0006;

[0135] Test conditions: laboratory temperature 20℃~24℃; relative humidity 60%~70%, no flushing. The test results are shown in Table 13.

[0136] Table 13 Test results

[0137]

[0138]

[0139] Test Example 3 shows that Example 3 of the present invention showed no irritating reaction in multiple (acute) skin irritation tests and eye irritation tests, and was mild and non-irritating.

[0140] In summary, the present invention creatively proposes an emulsifier-free, high-content, pure natural oil cream, which has the characteristics of no emulsifier, low preservative content, and high oil content, and the cream is mild and non-irritating, has good stability and antibacterial effect, and can meet the requirements of cosmetics. The preparation method is simple, easy to operate, and can be industrially produced.

[0141] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. An emulsifier-free, high-content, pure natural source oil cream, characterized in that: The raw materials for preparing the high-content pure natural oil cream include, by mass percentage, 30% to 40% of emollient, 5% to 10% of moisturizer, 0.5% to 5% of thickener, 0.01% to 0.2% of chelating agent, 0.01% to 0.5% of pH regulator and 0.6% to 1% of preservative, and the balance is water; The emollient is oil from pure natural sources; The thickener includes an acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, and the mass ratio of the acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer in the thickener to the pH adjuster is 1:0.9 to 1:1.

1.

2. The high-content pure natural source oil cream according to claim 1, characterized in that: Calculated by mass percentage, the raw materials for preparing the high-content pure natural oil cream include 32% to 38% of emollients, 6% to 8% of moisturizers, 2% to 3% of thickeners, 0.01% to 0.1% of chelating agents, 0.2% to 0.4% of pH regulators and 0.6% to 0.8% of preservatives, and the balance is water.

3. The high-content pure natural source oil cream according to claim 2, characterized in that: Calculated by mass percentage, the raw materials for preparing the high-content pure natural oil cream include 35% emollient, 7.1% moisturizer, 2.3% thickener, 0.05% chelating agent, 0.3% pH regulator and 0.6% preservative, and the balance is water.

4. The high-content pure natural oil cream according to any one of claims 1 to 3, characterized in that: The emollient includes at least one of squalane, coco-caprylate / caprate, jojoba seed oil, and meadowfoam seed oil.

5. The high-content pure natural oil cream according to any one of claims 1 to 3, characterized in that: The moisturizing agent includes at least one of glycerin, 1,3-butylene glycol, hyaluronic acid and hydrogenated lecithin.

6. The high-content pure natural oil cream according to any one of claims 1 to 3, characterized in that: The thickener further comprises at least one of carbomer and cetearyl alcohol.

7. The high-content pure natural oil cream according to any one of claims 1 to 3, characterized in that: The chelating agent includes EDTA-2Na.

8. The high-content pure natural oil cream according to any one of claims 1 to 3, characterized in that: The pH adjuster includes at least one of sodium hydroxide, aminomethyl propanol and arginine.

9. The high-content pure natural oil cream according to any one of claims 1 to 3, characterized in that: The preservative includes at least one of p-hydroxyacetophenone and 1,2-hexanediol.

10. A method for preparing a high-content pure natural oil cream as claimed in any one of claims 1 to 9, characterized in that: The following steps are involved: Water, moisturizer and chelating agent are mixed according to a proportion and then heated to obtain a first mixture; an emollient and a thickener are mixed and then heated to obtain a second mixture; the first mixture and the second mixture are mixed to obtain a third mixture; a pH adjuster is first added to the third mixture and then a preservative is added.

Images