Cosmetic composition containing ginseng extract and preparation method thereof
By preparing modified chitosan and ginseng liposomes, the problems of poor absorption and low stability of ginseng extracts in existing cosmetics are solved, and the high stability and good bioavailability of cosmetics are achieved, and its moisturizing Antibacterial and other effects.
Patent Information
- Application Number
- CN202411603498.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-12
- Publication Date
- 2025-02-11
AI Technical Summary
Existing cosmetic compositions containing ginseng extracts have poor absorption, low stability, poor dispersion and permeability in the skin, resulting in low bioavailability and difficulty in achieving delayed release effects.
By preparing modified chitosan, quaternary ammonium salts, hydrophobic segments and ether groups are introduced to impart amphiphilicity, combined with Tween 80 as a surfactant, stable ginseng liposomes are formed, and their products are improved in cosmetics. Dissolving dispersion and stability.
It improves the stability and biocompatibility of cosmetics, enhances moisturizing, antibacterial and emulsifying properties, improves penetration and absorption effects, and improves the efficacy and nutritional value of cosmetics.
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Abstract
Description
Technical Field
[0001] The invention relates to the technical field of cosmetics, in particular to a cosmetic composition containing ginseng extract and a preparation method thereof. Background Art
[0002] As consumers' demand for beauty continues to increase, the cosmetics market is showing a rapid growth trend, especially functional cosmetics such as anti-aging, moisturizing, and repairing are widely sought after. As a traditional Chinese medicinal material, ginseng is widely believed to have the effects of delaying aging, moisturizing, repairing, and anti-inflammatory because it contains a variety of biologically active ingredients such as ginsenosides, polysaccharides, and amino acids, making it one of the important raw materials in the cosmetics industry.
[0003] In the prior art, a cosmetic composition containing ginseng extract prepared by a traditional method has large ginseng nutrient molecules, which are not easily absorbed by the skin. At the same time, ginseng extract contains some hormones and active ingredients, which may interact with other ingredients in cosmetics, resulting in reduced stability of cosmetics. In addition, ginseng extract has poor dispersibility and permeability in cosmetics, and low bioavailability, making it difficult to deliver the coated natural active ingredients with targeted skin care technology to achieve a delayed release effect.
[0004] Therefore, it is of great significance to solve the above-mentioned existing defects and prepare a cosmetic composition containing ginseng extract. Summary of the invention
[0005] The object of the present invention is to provide a cosmetic composition containing ginseng extract and a preparation method thereof, so as to solve the problems raised in the above background technology.
[0006] To achieve the above object, the present invention provides the following technical solutions:
[0007] A method for preparing a cosmetic composition containing ginseng extract comprises the following steps:
[0008] Step 1: Preparation of ginseng extract: Wash and cut ginseng into pieces, add purified water and heat at 90-100° C. for 1-2 hours, repeat 2-3 times, filter, combine the filtrate, then concentrate under reduced pressure at 55-65° C., freeze-dry, and obtain ginseng extract;
[0009] Step 2: Preparation of ginseng liposomes: adding ginseng extract and mannitol to purified water in sequence to obtain an aqueous solution; adding phospholipids, cholesterol, Tween 80, and modified chitosan to anhydrous ethanol in sequence to obtain an ethanol solution; adding the ethanol solution to the aqueous solution, mixing evenly, and spray drying to obtain ginseng liposomes;
[0010] Step 3: Add allantoin and disodium edetate to purified water in sequence, and stir at 75-85° C. for 1-2 hours; cool to 45-55° C., add modified chitosan and glycerol in sequence, and stir for 20-30 minutes; after cooling to room temperature, add plant extract, ginseng extract, and ginseng liposomes and stir for 1-2 hours to obtain a cosmetic composition.
[0011] More optimally, the cosmetic composition comprises the following raw materials: based on 100 parts by mass, 3 to 4 parts of allantoin, 0.02 to 0.05 parts of disodium ethylenediaminetetraacetate, 4 to 6 parts of modified chitosan, 2 to 3 parts of glycerol, 3 to 5 parts of plant extracts, 1 to 2 parts of ginseng extracts, 6 to 8 parts of ginseng liposomes, and the rest is purified water.
[0012] More optimally, the plant extract includes the following raw materials in parts by weight: 5 to 8 parts of white lily extract, 4 to 6 parts of polygonatum extract, 4 to 6 parts of peony extract, 2 to 3 parts of truncatum extract, and 2 to 4 parts of licorice extract.
[0013] Wherein, white flower lily extract, polygonatum extract, peony extract, truncatum extract, licorice extract are added to the plant extract, and ginseng extract plays a synergistic effect, white flower lily extract, polygonatum extract and ginseng extract all have anti-aging effects, and the joint action can further enhance the anti-aging effect of the skin. Polygonatum extract and ginseng extract both have moisturizing effects, can prevent water loss, and keep the skin moist and moisturizing. Secondly, peony extract, truncatum extract and licorice extract all have whitening effects, and the joint action with ginseng extract can further enhance the whitening effect for the skin in the cosmetic composition. In addition, white flower lily extract, licorice extract and ginseng extract all have anti-inflammatory effects, which can further alleviate skin inflammation and sensitive problems.
[0014] More optimally, the ginseng liposomes include the following raw materials in parts by weight: 1 to 2 parts of ginseng extract, 0.5 to 20 parts of mannitol, 30 to 40 parts of purified water, 0.5 to 2 parts of phospholipids, 0.1 to 0.5 parts of cholesterol, 0.05 to 0.2 parts of Tween 80, 0.1 to 0.4 parts of modified chitosan, and 30 to 40 parts of anhydrous ethanol.
[0015] In a further scheme, the mass ratio of ginseng to purified water is 1:8-9.
[0016] Among them, modified chitosan is added to the ginseng liposomes, and quaternary ammonium salts, hydrophobic segments, ether groups and other groups are introduced to change its surface charge and hydrophilicity, making it amphiphilic, and able to form a stable interface between lipid components such as phospholipids and cholesterol and purified water, preventing the liposomes from agglomerating or rupturing during the preparation process, further increasing the stability and biocompatibility of the liposomes, and improving the stability and bioavailability of the ginseng liposomes; in addition, Tween 80, as a surfactant, assists in the uniform distribution of modified chitosan on the surface of the liposomes, enhances the dispersibility and stability of the liposomes, and improves the solubility and dispersibility of ginseng extract in cosmetics.
[0017] More optimally, the preparation method of the modified chitosan is:
[0018] Add epoxy quaternary ammonium salt, chitosan, epoxypentane and propylene glycol glycidyl ether into dimethylformamide solution, react at 120-160° C. for 8-10 hours, precipitate, purify and dry to obtain modified chitosan.
[0019] More optimally, the modified chitosan comprises the following raw materials in parts by weight: 5 to 6 parts of epoxy quaternary ammonium salt, 5 to 6 parts of chitosan, 0.5 to 1.5 parts of epoxypentane, 2 to 3 parts of propylene glycol glycidyl ether, and 35 to 45 parts of dimethylformamide solution.
[0020] More optimally, the chitosan has a deacetylation degree of 80-90%.
[0021] More optimally, the preparation method of the epoxy quaternary ammonium salt is:
[0022] Step 1: epichlorohydrin and dodecyldimethyl tertiary amine are mixed, reacted at 35-45° C. for 4-6 hours, then allowed to stand at -10--20° C. for 3-4 hours, filtered, purified, and dried to obtain raw material A;
[0023] Step 2: Add raw material A, bisamino polyethylene glycol and polyethylene glycol glycidyl ether to DMF, react at 50-60° C. for 8-14 hours, then add ethyl acetate to precipitate 3-5 times, purify, and dry to obtain an epoxy quaternary ammonium salt.
[0024] In the scheme, the preparation reaction principle of modified chitosan is as follows:
[0025] The first step: epichlorohydrin and dodecyldimethylamine undergo a nucleophilic addition reaction, followed by precipitation to obtain raw material A;
[0026] Step 2: An amino group in the bisamino polyethylene glycol undergoes a ring-opening reaction with the epoxy group in the above raw material A, and the mixture is combined. Then, the epoxy group in the polyethylene glycol glycidyl ether undergoes a ring-opening reaction with the amino group at the other end of the bisamino polyethylene glycol, and grafting is performed to introduce an ether group and a quaternary ammonium salt cationic group to obtain an epoxy quaternary ammonium salt, which changes the electron distribution and polarity of the hydrocarbon group, but still maintains the hydrophobic property as a whole;
[0027] The third step: chitosan, epoxypentane, and propylene glycol glycidyl ether are added, and DMF is used as a solvent, so that the amino groups in the chitosan are respectively grafted with the epoxy quaternary ammonium salt, epoxypentane, and the epoxy groups of propylene glycol glycidyl ether to undergo a ring-opening reaction at the same time, and hydrophobic segments, ether groups, and quaternary ammonium salt cationic groups are introduced, so that the modified chitosan is amphiphilic.
[0028] Among them, modified chitosan is added in the preparation of the cosmetic composition. Functional groups such as hydroxyl and amino groups in the modified chitosan can form hydrogen bonds with water molecules, have good moisturizing properties, help maintain the moisturizing and nourishing feeling of the cosmetics, and can work with allantoin to enhance the permeability and absorption effect of the cosmetics; the quaternary ammonium salt cationic group in the modified chitosan has a broad-spectrum antibacterial activity, can inhibit the growth and reproduction of microorganisms in cosmetics, extend the shelf life of cosmetics, and can play a synergistic role with plant extracts and ginseng extracts to enhance the efficacy and nutritional value of cosmetics; in addition, in the cosmetic composition, the modified chitosan can assist other emulsifiers (such as glycerin) to evenly mix the oil phase and the water phase to form a stable emulsion, and can work with glycerin to enhance the moisturizing performance and stability of the cosmetics.
[0029] More optimally, the epoxy quaternary ammonium salt comprises the following raw materials in parts by weight: 4 to 5 parts of epichlorohydrin, 1 to 3 parts of dodecyldimethyl tertiary amine, 5 to 6 parts of bisamino polyethylene glycol, 3 to 4 parts of polyethylene glycol glycidyl ether, and 35 to 45 parts of DMF.
[0030] Compared with the prior art, the present invention has the following beneficial effects:
[0031] 1. In the scheme, modified chitosan is prepared, and quaternary ammonium salts, hydrophobic segments and ether groups are introduced to give it amphiphilicity, effectively stabilize the liposome interface, prevent aggregation and rupture, improve liposome stability and biocompatibility, and enhance the solubility and dispersibility of ginseng extract. Tween 80 is used as a surfactant to further promote the uniform distribution of modified chitosan and enhance the dispersion stability of liposomes.
[0032] 2. In the scheme, adding modified chitosan to the preparation of the cosmetic composition can improve the stability and biocompatibility of the cosmetics, as well as enhance the moisturizing, antibacterial and emulsifying properties; at the same time, the modified chitosan can also improve the permeability and absorption effect of the cosmetics, and improve the efficacy and nutritional value of the cosmetics. DETAILED DESCRIPTION
[0033] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0034] It should be noted that the following parts are by mass, and all raw materials involved in the present invention are purchased from manufacturers without any special restrictions, and are exemplified as follows: in the following embodiments, the molecular weight of chitosan is 500, the product number is CS-3006, and it is purchased from Shanghai Zhenzhun Biotechnology Co., Ltd.; the purity of the white lily extract is 10%, and it is purchased from Fufeng Snot Biotechnology Co., Ltd.; the purity of the polygonatum extract is 10%, and it is purchased from Shaanxi Snot Biotechnology Co., Ltd.; the purity of the peony extract is 10%, and it is purchased from Sichuan Hongen Plant Technology Co., Ltd.; the purity of the truncatum extract is 10%, and it is purchased from Shanghai Koraman Reagent Co., Ltd.; the purity of the licorice extract is 10%, and it is purchased from Fufeng Snot Biotechnology Co., Ltd.
[0035] The cosmetic composition comprises the following raw materials: based on 100 parts by mass, 3.5 parts of allantoin, 0.04 parts of disodium edetate, 5 parts of modified chitosan, 2.5 parts of glycerol, 4 parts of plant extracts, 1.5 parts of ginseng extracts, 7 parts of ginseng liposomes, and the rest is purified water.
[0036] The plant extract includes the following raw materials in parts by weight: 6.5 parts of white lily extract, 5 parts of polygonatum odoratum extract, 5 parts of peony extract, 2.5 parts of truncatum extract, and 3 parts of liquorice extract.
[0037] The specific preparation process of modified chitosan is as follows:
[0038] Step 1: 4.5 parts of epichlorohydrin and 2 parts of dodecyldimethyl tertiary amine were mixed, reacted at 40°C for 5 hours, then allowed to stand at -15°C for 3.5 hours, filtered, purified, and dried to obtain raw material A;
[0039] Step 2: Add raw material A, 5.5 parts of bisamino polyethylene glycol, and 3.5 parts of polyethylene glycol glycidyl ether to 40 parts of DMF, react at 55° C. for 11 hours, then add ethyl acetate for precipitation 4 times, purify, and dry to obtain an epoxy quaternary ammonium salt;
[0040] Step 3: Add 5.5 parts of epoxy quaternary ammonium salt, 5.5 parts of chitosan, 1 part of epoxypentane, and 2.5 parts of propylene glycol glycidyl ether to 40 parts of dimethylformamide solution, react at 140° C. for 9 hours, precipitate, purify, and dry to obtain modified chitosan.
[0041] Embodiment 1: A method for preparing a cosmetic composition containing ginseng extract, comprising the following steps:
[0042] Step 1: Preparation of ginseng extract: Wash and cut ginseng into pieces, add purified water and heat at 95°C for 1.5 hours, the mass ratio of ginseng to purified water is 1:8.5, repeat 3 times, filter, combine the filtrate, then concentrate under reduced pressure at 60°C, freeze-dry, and obtain ginseng extract;
[0043] Step 2: Preparation of ginseng liposomes: 1.5 parts of ginseng extract and 10 parts of mannitol are added to 35 parts of purified water in sequence to obtain an aqueous solution; 1.2 parts of phospholipids, 0.3 parts of cholesterol, 0.12 parts of Tween 80, and 0.25 parts of modified chitosan are added to 35 parts of anhydrous ethanol in sequence to obtain an ethanol solution; the ethanol solution is added to the aqueous solution and mixed evenly, and spray-dried to obtain ginseng liposomes;
[0044] Step 3: Add allantoin and disodium ethylenediaminetetraacetate to purified water in sequence, and stir at 80°C for 1.5 hours; cool to 50°C, add modified chitosan and glycerol in sequence, and stir for 25 minutes; after cooling to room temperature, add plant extract, ginseng extract, and ginseng liposomes and stir for 1.5 hours to obtain a cosmetic composition.
[0045] Embodiment 2: A method for preparing a cosmetic composition containing ginseng extract, comprising the following steps:
[0046] Step 1: Preparation of ginseng extract: Wash and cut ginseng into pieces, add purified water and heat at 95°C for 1.5 hours, the mass ratio of ginseng to purified water is 1:8.5, repeat 3 times, filter, combine the filtrate, then concentrate under reduced pressure at 60°C, freeze-dry, and obtain ginseng extract;
[0047] Step 2: Preparation of ginseng liposomes: 1 part of ginseng extract and 0.5 part of mannitol are added to 30 parts of purified water in sequence to obtain an aqueous solution; 0.5 parts of phospholipids, 0.1 parts of cholesterol, 0.05 parts of Tween 80, and 0.1 parts of modified chitosan are added to 30 parts of anhydrous ethanol in sequence to obtain an ethanol solution; the ethanol solution is added to the aqueous solution and mixed evenly, and spray-dried to obtain ginseng liposomes;
[0048] Step 3: Add allantoin and disodium ethylenediaminetetraacetate to purified water in sequence, and stir at 80°C for 1.5 hours; cool to 50°C, add modified chitosan and glycerol in sequence, and stir for 25 minutes; after cooling to room temperature, add plant extract, ginseng extract, and ginseng liposomes and stir for 1.5 hours to obtain a cosmetic composition.
[0049] Embodiment 3: A method for preparing a cosmetic composition containing ginseng extract, comprising the following steps:
[0050] Step 1: Preparation of ginseng extract: Wash and cut ginseng into pieces, add purified water and heat at 95°C for 1.5 hours, the mass ratio of ginseng to purified water is 1:8.5, repeat 3 times, filter, combine the filtrate, then concentrate under reduced pressure at 60°C, freeze-dry, and obtain ginseng extract;
[0051] Step 2: Preparation of ginseng liposomes: 2 parts of ginseng extract and 20 parts of mannitol are added to 40 parts of purified water in sequence to obtain an aqueous solution; 2 parts of phospholipids, 0.5 parts of cholesterol, 0.2 parts of Tween 80, and 0.4 parts of modified chitosan are added to 40 parts of anhydrous ethanol in sequence to obtain an ethanol solution; the ethanol solution is added to the aqueous solution and mixed evenly, and spray-dried to obtain ginseng liposomes;
[0052] Step 3: Add allantoin and disodium ethylenediaminetetraacetate to purified water in sequence, and stir at 80°C for 1.5 hours; cool to 50°C, add modified chitosan and glycerol in sequence, and stir for 25 minutes; after cooling to room temperature, add plant extract, ginseng extract, and ginseng liposomes and stir for 1.5 hours to obtain a cosmetic composition.
[0053] Comparative Example 1: Based on Example 1, modified chitosan was not added when preparing ginseng liposomes, and the other processes remained unchanged, specifically:
[0054] Step 1: Preparation of ginseng extract: Wash and cut ginseng into pieces, add purified water and heat at 95°C for 1.5 hours, the mass ratio of ginseng to purified water is 1:8.5, repeat 3 times, filter, combine the filtrate, then concentrate under reduced pressure at 60°C, freeze-dry, and obtain ginseng extract;
[0055] Step 2: Preparation of ginseng liposomes: 1.5 parts of ginseng extract and 10 parts of mannitol are added to 35 parts of purified water in sequence to obtain an aqueous solution; 1.2 parts of phospholipids, 0.3 parts of cholesterol, and 0.3 parts of Tween 80 are added to 35 parts of anhydrous ethanol in sequence to obtain an ethanol solution; the ethanol solution is added to the aqueous solution and mixed evenly, and spray-dried to obtain ginseng liposomes;
[0056] Step 3: Add allantoin and disodium ethylenediaminetetraacetate to purified water in sequence, and stir at 80°C for 1.5 hours; cool to 50°C, add modified chitosan and glycerol in sequence, and stir for 25 minutes; after cooling to room temperature, add plant extract, ginseng extract, and ginseng liposomes and stir for 1.5 hours to obtain a cosmetic composition.
[0057] Comparative Example 2: Based on Example 1, ordinary chitosan was added when preparing the cosmetic composition, and the other processes remained unchanged, specifically:
[0058] Step 1: Preparation of ginseng extract: Wash and cut ginseng into pieces, add purified water and heat at 95°C for 1.5 hours, the mass ratio of ginseng to purified water is 1:8.5, repeat 3 times, filter, combine the filtrate, then concentrate under reduced pressure at 60°C, freeze-dry, and obtain ginseng extract;
[0059] Step 2: Preparation of ginseng liposomes: 1.5 parts of ginseng extract and 10 parts of mannitol are added to 35 parts of purified water in sequence to obtain an aqueous solution; 1.2 parts of phospholipids, 0.3 parts of cholesterol, 0.12 parts of Tween 80, and 0.25 parts of modified chitosan are added to 35 parts of anhydrous ethanol in sequence to obtain an ethanol solution; the ethanol solution is added to the aqueous solution and mixed evenly, and spray-dried to obtain ginseng liposomes;
[0060] Step 3: Add allantoin and disodium edetate to purified water in sequence, and stir at 80°C for 1.5 hours; cool to 50°C, add chitosan and glycerol in sequence, and stir for 25 minutes; after cooling to room temperature, add plant extract, ginseng extract, and ginseng liposomes, and stir for 1.5 hours to obtain a cosmetic composition.
[0061] The cosmetic composition in the above steps comprises the following raw materials: based on 100 parts by mass, 3.5 parts of allantoin, 0.04 parts of disodium edetate, 5 parts of chitosan, 2.5 parts of glycerol, 4 parts of plant extracts, 1.5 parts of ginseng extracts, 7 parts of ginseng liposomes, and the rest is purified water.
[0062] Comparative Example 3: Based on Example 1, no modified chitosan was added when preparing the cosmetic composition, and the other processes remained unchanged, specifically:
[0063] Step 1: Preparation of ginseng extract: Wash and cut ginseng into pieces, add purified water and heat at 95°C for 1.5 hours, the mass ratio of ginseng to purified water is 1:8.5, repeat 3 times, filter, combine the filtrate, then concentrate under reduced pressure at 60°C, freeze-dry, and obtain ginseng extract;
[0064] Step 2: Preparation of ginseng liposomes: 1.5 parts of ginseng extract and 10 parts of mannitol are added to 35 parts of purified water in sequence to obtain an aqueous solution; 1.2 parts of phospholipids, 0.3 parts of cholesterol, 0.12 parts of Tween 80, and 0.25 parts of modified chitosan are added to 35 parts of anhydrous ethanol in sequence to obtain an ethanol solution; the ethanol solution is added to the aqueous solution and mixed evenly, and spray-dried to obtain ginseng liposomes;
[0065] Step 3: Add allantoin and disodium edetate to purified water in sequence, and stir at 80°C for 1.5 hours; cool to 50°C, add glycerol in sequence, and stir for 25 minutes; after cooling to room temperature, add plant extract, ginseng extract, and ginseng liposomes, and stir for 1.5 hours to obtain a cosmetic composition.
[0066] The cosmetic composition in the above steps comprises the following raw materials: based on 100 parts by mass, 3.7 parts of allantoin, 0.04 parts of disodium edetate, 3 parts of glycerin, 4 parts of plant extract, 1.5 parts of ginseng extract, 7 parts of ginseng liposomes, and the rest is purified water.
[0067] Comparative Example 4: Based on Example 1, ordinary chitosan was added during the preparation of ginseng liposomes, and the rest of the process remained unchanged, specifically:
[0068] Step 1: Preparation of ginseng extract: Wash and cut ginseng into pieces, add purified water and heat at 95°C for 1.5 hours, the mass ratio of ginseng to purified water is 1:8.5, repeat 3 times, filter, combine the filtrate, then concentrate under reduced pressure at 60°C, freeze-dry, and obtain ginseng extract;
[0069] Step 2: Preparation of ginseng liposomes: 1.5 parts of ginseng extract and 10 parts of mannitol are added to 35 parts of purified water in sequence to obtain an aqueous solution; 1.2 parts of phospholipids, 0.3 parts of cholesterol, 0.12 parts of Tween 80, and 0.25 parts of chitosan are added to 35 parts of anhydrous ethanol in sequence to obtain an ethanol solution; the ethanol solution is added to the aqueous solution and mixed evenly, and spray-dried to obtain ginseng liposomes;
[0070] Step 3: Add allantoin and disodium ethylenediaminetetraacetate to purified water in sequence, and stir at 80°C for 1.5 hours; cool to 50°C, add modified chitosan and glycerol in sequence, and stir for 25 minutes; after cooling to room temperature, add plant extract, ginseng extract, and ginseng liposomes and stir for 1.5 hours to obtain a cosmetic composition.
[0071] Testing experiment: The ginseng extract compositions prepared in Examples 1 to 3 and Comparative Examples 1 to 4 were subjected to performance testing: (1) Ginsenoside content test: The ginseng extract compositions prepared in Examples 1 to 3 and Comparative Examples 1 to 4 were tested for ginsenoside content by high performance liquid chromatography, as shown in Table 1; (2) Total permeability test: The permeability of the ginseng total saponin liposomes prepared in Examples 1 to 3 and Comparative Examples 1 to 4 within 24 hours was tested, as shown in Table 1;
[0072]
[0073] Table 1
[0074] Result analysis: According to the data analysis in Table 1, it can be seen that by preparing modified chitosan, introducing quaternary ammonium salts, hydrophobic segments and ether groups, giving it amphiphilicity, effectively stabilizing the liposome interface, preventing aggregation and rupture, improving the stability and biocompatibility of liposomes, and enhancing the solubility and dispersibility of ginseng extract; by adding modified chitosan to the preparation of the cosmetic composition, the stability and biocompatibility of the cosmetic can be improved, and the moisturizing, antibacterial and emulsifying properties can be enhanced; at the same time, the modified chitosan can also improve the permeability and absorption effect of the cosmetics, and improve the efficacy and nutritional value of the cosmetics.
[0075] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the present invention can be implemented in other specific forms without departing from the spirit or essential features of the present invention. Therefore, the embodiments should be considered exemplary and non-restrictive in all respects, and the scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims be included in the present invention.
Claims
1. A method for preparing a cosmetic composition containing ginseng extract, characterized in that: The following steps are involved: Step 1: Preparation of ginseng extract: Wash and cut ginseng into pieces, add purified water and heat at 90-100° C. for 1-2 hours, repeat 2-3 times, filter, combine the filtrate, then concentrate under reduced pressure at 55-65° C., freeze-dry, and obtain ginseng extract; Step 2: Preparation of ginseng liposomes: adding ginseng extract and mannitol to purified water in sequence to obtain an aqueous solution; adding phospholipids, cholesterol, Tween 80, and modified chitosan to anhydrous ethanol in sequence to obtain an ethanol solution; adding the ethanol solution to the aqueous solution, mixing evenly, and spray drying to obtain ginseng liposomes; Step 3: Add allantoin and disodium edetate to purified water in sequence, and stir at 75-85° C. for 1-2 hours; cool to 45-55° C., add modified chitosan and glycerol in sequence, and stir for 20-30 minutes; after cooling to room temperature, add plant extract, ginseng extract, and ginseng liposomes and stir for 1-2 hours to obtain a cosmetic composition.
2. The method for preparing a cosmetic composition containing ginseng extract according to claim 1, characterized in that: The cosmetic composition comprises the following raw materials: based on 100 parts by mass, 3 to 4 parts of allantoin, 0.02 to 0.05 parts of disodium ethylenediaminetetraacetate, 4 to 6 parts of modified chitosan, 2 to 3 parts of glycerol, 3 to 5 parts of plant extracts, 1 to 2 parts of ginseng extracts, 6 to 8 parts of ginseng liposomes, and the rest is purified water.
3. The method for preparing a cosmetic composition containing ginseng extract according to claim 1, characterized in that: The plant extract comprises the following raw materials in parts by weight: 5 to 8 parts of white lily extract, 4 to 6 parts of polygonatum odoratum extract, 4 to 6 parts of peony extract, 2 to 3 parts of truncatum extract, and 2 to 4 parts of liquorice extract.
4. The method for preparing a cosmetic composition containing ginseng extract according to claim 1, characterized in that: The ginseng liposome comprises the following raw materials in parts by weight: 1-2 parts of ginseng extract, 0.5-20 parts of mannitol, 30-40 parts of purified water, 0.5-2 parts of phospholipids, 0.1-0.5 parts of cholesterol, 0.05-0.2 parts of Tween 80, 0.1-0.4 parts of modified chitosan, and 30-40 parts of anhydrous ethanol.
5. The method for preparing a cosmetic composition containing ginseng extract according to claim 1, characterized in that: The preparation method of the modified chitosan is: Add epoxy quaternary ammonium salt, chitosan, epoxypentane and propylene glycol glycidyl ether into dimethylformamide solution, react at 120-160° C. for 8-10 hours, precipitate, purify and dry to obtain modified chitosan.
6. The method for preparing a cosmetic composition containing ginseng extract according to claim 5, characterized in that: The modified chitosan comprises the following raw materials in parts by weight: 5-6 parts of epoxy quaternary ammonium salt, 5-6 parts of chitosan, 0.5-1.5 parts of epoxypentane, 2-3 parts of propylene glycol glycidyl ether, and 35-45 parts of dimethylformamide solution.
7. The method for preparing a cosmetic composition containing ginseng extract according to claim 5, characterized in that: The chitosan has a deacetylation degree of 80-90%.
8. The method for preparing a cosmetic composition containing ginseng extract according to claim 6, characterized in that: The preparation method of the epoxy quaternary ammonium salt is: Step 1: epichlorohydrin and dodecyldimethyl tertiary amine are mixed, reacted at 35-45° C. for 4-6 hours, then allowed to stand at -10--20° C. for 3-4 hours, filtered, purified, and dried to obtain raw material A; Step 2: Add raw material A, bisamino polyethylene glycol and polyethylene glycol glycidyl ether to DMF, react at 50-60° C. for 8-14 hours, then add ethyl acetate to precipitate 3-5 times, purify, and dry to obtain an epoxy quaternary ammonium salt.
9. The method for preparing a cosmetic composition containing ginseng extract according to claim 8, characterized in that: The epoxy quaternary ammonium salt comprises the following raw materials in parts by weight: 4 to 5 parts of epichlorohydrin, 1 to 3 parts of dodecyldimethyl tertiary amine, 5 to 6 parts of bisamino polyethylene glycol, 3 to 4 parts of polyethylene glycol glycidyl ether, and 35 to 45 parts of DMF.
10. The ginseng extract composition prepared by the method for preparing a cosmetic composition containing ginseng extract according to any one of claims 1 to 9.