Biosafety type small animal whole body exposure device
By setting a combined flow balancing plate and a support flow balancing plate in the exposure cavity of the animal exposure device, the problem of insufficient uniformity of the aerosol inhalation at different locations of the experimental animals was solved, and the accuracy of the experimental results was improved.
Patent Information
- Application Number
- CN202411897486.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-23
- Publication Date
- 2025-02-14
AI Technical Summary
In animal exposure devices, the uniformity of experimental animals inhaling aerosols at different locations is insufficient, which affects the accuracy of the experimental results.
A biosafety animal whole body exposure device is designed, and by providing a combined flow balancing plate inside the exposure cavity, including a multi-layer flow balancing plate and a support flow balancing plate, the uniform diffusion and transmission of the aerosol in the exposed cavity is ensured.
It effectively ensures the uniform diffusion of aerosols in the exposed cavity and the uniformity of animal inhalation, thereby improving the accuracy of experimental results.
Smart Images
Figure CN119424033A_ABST
Abstract
Description
Technical Field
[0001] The present application relates to the field of exposure devices, and in particular to a biosafety small animal whole-body exposure device. Background Art
[0002] Generally speaking, inhalation toxicology experiments simulate the ways in which workers and residents are exposed to toxic substances. They conduct static or dynamic inhalation exposure to industrial chemicals in the production environment and environmental pollutants in the atmosphere of residential areas to obtain inhalation toxicology data, including the mechanism of action of inhalation toxicity (such as median lethal concentration, harmless action concentration, etc.) and the results of experimental treatment. They are important bases for formulating harmful substances in workshop air and residential atmosphere. At present, in various scientific studies related to inhalation toxicology, especially the research on some substances harmful to human health, such as PM2.5, experimental animals are often used for inhalation exposure evaluation because it is impossible to directly or firstly conduct experiments on humans. Therefore, animal exposure devices are widely used in industrial, agricultural, medical, environmental pollution and military scientific research. For example, experimental animals, such as mice, are placed in an exposure chamber and aerosols are introduced into the exposure chamber for experiments.
[0003] In addition, during the experiment in the exposure chamber, multiple experimental animals will be placed in different positions according to the experimental requirements. The uniformity of the aerosol inhaled by the experimental animals in different positions will affect the accuracy of the experimental results to a certain extent. Therefore, it is necessary to design a whole-body exposure device that can ensure the uniformity of aerosol inhalation by different experimental animals. Summary of the invention
[0004] In view of the above problems, the present application is proposed to provide a biosafety small animal whole-body exposure device that overcomes the above problems or at least partially solves the above problems.
[0005] The biosafety small animal whole body exposure device provided in this application adopts the following technical solution: A biosafety small animal whole body exposure device comprises an exposure chamber with upper and lower ends arranged in a funnel shape, and the upper and lower ends of the exposure chamber are respectively connected to an air inlet and an air outlet, and a plurality of animal cages are arranged in the exposure chamber along its length direction, and the animal cages are used to place experimental animals; A combined flow balancing plate and a supporting flow balancing plate are arranged in the exposure cavity, the combined flow balancing plate is located below the air inlet, and a gap is set between the combined flow balancing plate and the air inlet; the supporting flow balancing plate is arranged below the animal cage, and a gap is set between the supporting flow balancing plate, the animal cage and the air outlet; The combined flow averaging plate comprises a first flow averaging plate, a pair of second flow averaging plates and a pair of third flow averaging plates, wherein the first flow averaging plate is arranged directly below the air inlet, the second flow averaging plate and the third flow averaging plate are symmetrically distributed on both sides of the first flow averaging plate in sequence, and the first flow averaging plate, the second flow averaging plate and the third flow averaging plate are all provided with flow averaging holes; The flow equalizing holes on the first flow equalizing plate are distributed in a circular diffusion shape with the air inlet as the center; the multiple rows of flow equalizing holes on the second flow equalizing plate are gradually densely arranged in the direction away from the first flow equalizing plate; the multiple rows of flow equalizing holes on the third flow equalizing plate are evenly arranged, but their density is greater than the flow equalizing holes arranged on the second flow equalizing plate.
[0006] Optionally, the flow balancing holes arranged on the first flow balancing plate, the second flow balancing plate and the third flow balancing plate have the same aperture.
[0007] Optionally, the combined flow balancing plate also includes a pair of fourth flow balancing plates, which are distributed on the outside of the third flow balancing plate. The fourth flow balancing plates are also provided with flow balancing holes, and the aperture diameter of the flow balancing holes provided on the fourth flow balancing plates is larger than the aperture diameter of the flow balancing holes provided on the third flow balancing plate.
[0008] Optionally, arc-shaped long holes are provided at the four corners of the first current equalizing plate.
[0009] Optionally, a plurality of support frames are arranged on the supporting flow equalizing plate along its length direction, and the support frames are provided with support bars for supporting the animal cages, and the cross-section of the support bars is L-shaped.
[0010] Optionally, the lower end of the exposure cavity is also connected to a sewage outlet.
[0011] In summary, the present application includes the following beneficial technical effects: the present application effectively ensures the uniformity of aerosol diffusion inside the exposure chamber by setting a combined equalizing plate inside the exposure chamber, thereby effectively ensuring the uniformity of aerosol inhaled by animals, thereby ensuring the accuracy of experimental results. BRIEF DESCRIPTION OF THE DRAWINGS
[0012] Figure 1 It is a schematic diagram of the overall structure of an embodiment of the present application.
[0013] Figure 2 It is a schematic diagram of the connection relationship between the combined current equalizing plate and the exposed cavity in the embodiment of the present application.
[0014] Figure 3 It is a schematic diagram of the structure of the combined current equalizing plate in the embodiment of the present application.
[0015] Figure 4 It is a schematic diagram of the connection relationship between the animal cage and the supporting equalizing plate in the embodiment of the present application.
[0016] Explanation of the accompanying drawings: 1. Exposure chamber; 11. Mixing chamber; 111. Air inlet; 12. Collection chamber; 121. Air outlet; 122. Sewage outlet; 2. Combined equalizing plate; 21. First equalizing plate; 211. Arc-shaped long strip hole; 22. Second equalizing plate; 23. Third equalizing plate; 24. Fourth equalizing plate; 3. Support equalizing plate; 31. Support frame; 311. Support bar; 4. Animal cage. DETAILED DESCRIPTION
[0017] In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiment is one embodiment of the present invention, not all embodiments. Based on the described embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0018] Unless otherwise defined, technical or scientific terms used in the present invention shall have the common meanings understood by one having ordinary skills in the field to which the present invention belongs.
[0019] This embodiment provides a biosafety small animal whole-body exposure device.
[0020] Reference Figure 1-Figure 3 The biosafety small animal whole body exposure device comprises an exposure chamber 1, wherein the upper and lower ends of the exposure chamber 1 are respectively connected with a mixing chamber 11 and a collecting chamber 12, the mixing chamber 11 and the collecting chamber 12 are both arranged in a funnel shape, and the mixing chamber 11 and the collecting chamber 12 are arranged symmetrically. The top of the mixing chamber 11 is connected with an air inlet 111, and the bottom of the collecting chamber 12 is connected with an air outlet 121.
[0021] A combined equalizing plate 2 and a supporting equalizing plate 3 are arranged in the exposure cavity 1. The combined equalizing plate 2 is arranged below the air inlet 111, and a gap is arranged between the combined equalizing plate 2 and the air inlet 111. The combined equalizing plate 2 includes a first equalizing plate 21, a pair of second equalizing plates 22 and a pair of third equalizing plates 23.
[0022] A pair of second current balancing plates 22 and a pair of third current balancing plates 23 are symmetrically distributed on both sides of the first current balancing plate 21, that is, a pair of second current balancing plates 22 are distributed on both sides of the first current balancing plate 21, and a pair of third current balancing plates 23 are respectively distributed on one side of the pair of second current balancing plates 22 away from the pair of first current balancing plates 21; the first current balancing plate 21, the second current balancing plate 22 and the third current balancing plate 23 are all provided with flow balancing holes, and the apertures of the flow balancing holes provided on the first current balancing plate 21, the second current balancing plate 22 and the third current balancing plate 23 are the same.
[0023] The first flow equalizing plate 21 is arranged directly below the air inlet 111. The flow velocity of the aerosol entering the mixing chamber 11 is the largest here. Therefore, the flow equalizing holes arranged on the first flow equalizing plate 21 are distributed in a circular diffusion shape with the air inlet 111 as the center. In order to enable the aerosol to be evenly distributed at the four corners of the first flow equalizing plate 21, arc-shaped long strip holes 211 are also provided at the four corners of the first flow equalizing plate 21.
[0024] Since the aerosol flow rate is fastest in the middle of the air outlet 121 and diffuses slowest at the left and right ends, according to this principle, multiple rows of flow equalizing holes on the second flow equalizing plate 22 are gradually densely arranged in the direction away from the first flow equalizing plate 21, that is, multiple rows of flow equalizing holes are arranged from sparse to dense in the direction away from the first flow equalizing plate 21, thereby reducing the transmission resistance of the aerosol and keeping the speed of the aerosol passing through the first flow equalizing plate 21 and the second flow equalizing plate 22 into the exposure chamber 1 uniform.
[0025] Since a portion of the aerosol input into the mixing chamber 11 has been transmitted downward during the transmission along the first flow equalizing plate 21 and the second flow equalizing plate 22, the speed of the aerosol transmitted to the third flow equalizing plate 23 is already very slow at this time. Therefore, multiple rows of flow equalizing holes are evenly arranged on the third flow equalizing plate 23, and the density of the flow equalizing holes on the third flow equalizing plate 23 is greater than the density of the flow equalizing holes on the second flow equalizing plate 22, thereby further reducing the transmission resistance of the aerosol, so that the speed of the aerosol entering the exposure chamber 1 through the third flow equalizing plate 23 and the first flow equalizing plate 21 and the second flow equalizing plate 22 remains uniform.
[0026] The combined flow equalizing plate 2 may also include a pair of fourth flow equalizing plates 24, which are distributed on the side of the third flow equalizing plate 23 away from the second flow equalizing plate 22. The fourth flow equalizing plate 24 is also provided with multiple rows of flow equalizing holes. Since the speed of aerosol transmission to the fourth flow equalizing plate 24 is reduced again, the aperture of the multiple rows of flow equalizing holes evenly distributed on the fourth flow equalizing plate 24 is larger than the aperture of the flow equalizing holes arranged on the third flow equalizing plate 23, so as to further reduce the transmission resistance of the aerosol, so that the speed of the aerosol entering the exposure chamber 1 through the fourth flow equalizing plate 24 and the first flow equalizing plate 21, the second flow equalizing plate 22 and the third flow equalizing plate 23 is kept uniform, so that the aerosol entering the exposure chamber 1 from the mixing chamber 11 produces a vertical laminar flow, thereby achieving the effect of equal flow, and ensuring the uniformity of the inhaled dose of animals at different positions in the animal whole-body exposure experiment.
[0027] Reference Figure 1 and Figure 4The support equalizing plate 3 is arranged at the lower end of the exposure chamber 1, and multiple rows of equalizing holes are evenly distributed on the support equalizing plate 3 along its length direction, and a gap is set between the support equalizing plate 3 and the air outlet 121 to equalize the aerosol entering the collection chamber 12 from the exposure chamber 1 to prevent the aerosol from presenting a turbulent state. Animal cages 4 for placing experimental animals are also arranged in the exposure chamber 1 along its length direction, and the support equalizing plate 3 is used to carry the animal cages 4.
[0028] A plurality of support frames 31 are arranged along the length direction of the support equalizing plate 3, and a support bar 311 with an L-shaped cross-section is arranged on the support frame 31. A gap is arranged between the support bar 311 and the support equalizing plate 3, and the relatively arranged support bars 311 are used to support the animal cage, so that the animal cage 4 can be installed while ensuring the circulation of airflow under the animal cage 4.
[0029] Reference Figure 1 In order to facilitate the treatment of the excrement of the experimental animals, a sewage outlet 122 is also provided at the bottom of the collecting chamber 12 .
[0030] The implementation principle of a biosafety small animal whole-body exposure device in an embodiment of the present application is as follows: the aerosol is transmitted downward in a conical shape after passing through the air inlet 111, and diffuses downward and to the left and right after hitting the first flow equalizing plate 21, and gradually passes through the second flow equalizing plate 22, the third flow equalizing plate 23, and the fourth flow equalizing plate 24 at each position for downward flow equalization transmission, reaches the exposure chamber 1 from the mixing chamber 11, and is transmitted to the animal cage 4 in the exposure chamber 1 for the experimenter to complete the animal whole-body exposure experiment. The aerosol after the animal whole-body exposure continues to pass downward through the supporting flow equalizing plate 3, is transmitted to the collection chamber 12, and is then discharged through the air outlet 121.
[0031] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.
Claims
1. Biosafety small animal whole body exposure device, characterized by: The invention comprises an exposure chamber (1) with upper and lower ends arranged in a funnel shape, wherein the upper and lower ends of the exposure chamber (1) are respectively connected with an air inlet (111) and an air outlet (121), and a plurality of animal cages (4) are arranged in the exposure chamber (1) along the length direction thereof, and the animal cages (4) are used to place experimental animals; The exposure cavity (1) is provided with a combined flow averaging plate (2) and a supporting flow averaging plate (3); the combined flow averaging plate (2) is located below the air inlet (111), and a gap is set between the combined flow averaging plate (2) and the air inlet (111); the supporting flow averaging plate (3) is arranged below the animal cage (4), and a gap is set between the supporting flow averaging plate (3), the animal cage (4) and the air outlet (121); The combined flow balancing plate (2) comprises a first flow balancing plate (21), a pair of second flow balancing plates (22) and a pair of third flow balancing plates (23), wherein the first flow balancing plate (21) is arranged directly below the air inlet (111), the second flow balancing plate (22) and the third flow balancing plate (23) are symmetrically distributed on both sides of the first flow balancing plate (21), and the first flow balancing plate (21), the second flow balancing plate (22) and the third flow balancing plate (23) are all provided with flow balancing holes; The flow equalizing holes on the first flow equalizing plate (21) are distributed in a circular diffusion shape with the air inlet (111) as the center; the multiple rows of flow equalizing holes on the second flow equalizing plate (22) are gradually densely arranged in a direction away from the first flow equalizing plate (21); and the multiple rows of flow equalizing holes on the third flow equalizing plate (23) are evenly arranged, but their density is greater than that of the flow equalizing holes arranged on the second flow equalizing plate (22).
2. The biosafety small animal whole body exposure device according to claim 1, characterized in that: The flow balancing holes arranged on the first flow balancing plate (21), the second flow balancing plate (22) and the third flow balancing plate (23) have the same aperture.
3. The biosafety small animal whole body exposure device according to claim 1, characterized in that: The combined flow balancing plate (2) further includes a pair of fourth flow balancing plates (24), wherein the fourth flow balancing plates (24) are distributed outside the third flow balancing plate (23), and the fourth flow balancing plates (24) are also provided with flow balancing holes, and the aperture of the flow balancing holes provided on the fourth flow balancing plates (24) is larger than the aperture of the flow balancing holes provided on the third flow balancing plate (23).
4. The biosafety small animal whole body exposure device according to claim 1, characterized in that: Arc-shaped long holes (211) are provided at the four corners of the first flow equalizing plate (21).
5. The biosafety small animal whole body exposure device according to claim 1, characterized in that: The supporting flow equalizing plate (3) is provided with a plurality of supporting frames (31) along its length direction, and the supporting frames (31) are provided with supporting bars (311) for supporting the animal cage (4), and the cross section of the supporting bars (311) is L-shaped.
6. The biosafety small animal whole body exposure device according to claim 1, characterized in that: The lower end of the exposure chamber (1) is also connected to a sewage outlet (122).