Traditional Chinese medicine composition for treating rheumatism and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions. The invention provides a traditional Chinese medicine composition for treating rheumatism and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 8-12 parts of safflower, 8-12 parts of selaginella tamariscina, 8-12 parts of radix saposhnikoviae, 13-17 parts of rhizoma atractylodis, 18-22 parts of garden balsam stem, 18-22 parts of lycopodium clavatum, 8-12 parts of cassia twig, 2-4 parts of asarum, 13-17 parts of gentiana macrophylla, 8-12 parts of ligusticum wallichii, 13-17 parts of pawpaw, 8-12 parts of frankincense, 8-12 parts of myrrh, 8-12 parts of radix aconiti carmichaeli, 8-12 parts of rhizoma cibotii, 8-12 parts of notopterygium root and 4-6 parts of scorpion. The traditional Chinese medicine composition can effectively treat rheumatism, and is remarkable in effect and rapid in pain relieving.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine compositions, and in particular to a Chinese medicine composition for treating rheumatism and a preparation method thereof. Background Art

[0002] Rheumatism is a group of diseases that mainly invade joints, bones, muscles, blood vessels and related soft tissues or connective tissues, most of which are autoimmune diseases. The onset is often hidden and slow, the course of the disease is long, and most of them have a genetic tendency. Both diagnosis and treatment are difficult; different autoantibodies can be detected in the blood, which may be related to different HLA subtypes.

[0003] When rheumatism occurs, joint pain and skin lesions greatly affect daily work and rest. Rheumatism is a chronic disease that is difficult to cure. When it occurs, it is painful and affects work and rest. Existing Western medicine treatment is quick, but it only treats the symptoms and not the root cause. It relapses when the drug is stopped. The side effects are very large, and it is easy to cause lifelong diseases and complications, such as damaging the nervous system, liver and kidney and other internal organs, causing endocrine disorders, gastric bleeding and other diseases. Existing Chinese medicine has a single curative effect, slow effect, low cure rate, and long treatment course. Therefore, it is particularly urgent to develop a new Chinese medicine composition for the treatment of rheumatism. Summary of the invention

[0004] The purpose of the present invention is to provide a Chinese medicine composition for treating rheumatism and a preparation method thereof, which can effectively treat rheumatism, has a significant effect and can quickly relieve pain.

[0005] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0006] The invention provides a traditional Chinese medicine composition for treating rheumatism. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 8-12 parts of safflower, 8-12 parts of selaginella, 8-12 parts of siler, 13-17 parts of atractylodes, 18-22 parts of radix spatholobi, 18-22 parts of herba lycopodii, 8-12 parts of cassia twig, 2-4 parts of asarum, 13-17 parts of gentiana macrophylla, 8-12 parts of ligusticum chuanxiong, 13-17 parts of papaya, 8-12 parts of frankincense, 8-12 parts of myrrh, 8-12 parts of aconite, 8-12 parts of cibotium barometz, 8-12 parts of notopterygium wilfordii and 4-6 parts of scorpion.

[0007] Preferably, the Chinese medicine composition comprises the following raw materials in parts by weight: 10 parts of safflower, 10 parts of Selaginella, 10 parts of Saposhnikovia, 15 parts of Atractylodes, 20 parts of Herba Polygoni Multiflori, 20 parts of Herba Lycopodii, 10 parts of Cassia Twig, 3 parts of Asarum, 15 parts of Gentiana Macrophylla, 10 parts of Rhizoma Chuanxiong, 15 parts of Papaya, 10 parts of frankincense, 10 parts of myrrh, 10 parts of Aconite, 10 parts of Cibotium barometz, 10 parts of Notopterygium wilfordii, and 5 parts of Scorpio.

[0008] The present invention also provides a method for preparing the Chinese medicine composition, comprising the following steps:

[0009] (1) Weigh safflower, selaginella, siler, atractylodes, radix scutellariae, herba schizonepetae, herba cassiae, cassia twig, asarum, gentiana macrophyllae, rhizoma chuanxiong, papaya, frankincense, myrrh, aconite, cibotium barometz, notopterygium wilfordii, and scorpion according to proportion and set aside;

[0010] (2) crushing and mixing Selaginella, Saposhnikovia divaricata, Atractylodes macrocephala, Lycopodiella cuneata, Cinnamomum cassia, Asarum, Gentiana macrophylla, Ligusticum chuanxiong, Chaenomeles sinensis, Olibanum, Myrrha, Cibotium barometz and Notopterygium wilfordii to obtain a raw material powder;

[0011] (3) soaking the raw material powder in water and then boiling it to separate and obtain a filter residue and a filtrate 1;

[0012] (4) adding water to the filter residue and boiling it twice to separate and obtain filtrate 2;

[0013] (5) mixing safflower, radix polygoni lobatae, scorpion and aconite root to obtain a mixture, soaking in ethanol solution, decocting, and filtering to obtain filtrate 3;

[0014] (6) combining filtrate 1, filtrate 2 and filtrate 3, and concentrating them into an extract to obtain the Chinese medicine composition.

[0015] Preferably, the particle size of the raw material powder in step (2) is 40 to 60 meshes.

[0016] Preferably, in step (3), the mass ratio of the raw material powder to water is 1:10-15, the soaking temperature is 30-40°C, the soaking time is 40-60 min, and the decoction time is 30-40 min.

[0017] Preferably, in step (4), the mass ratio of the filter residue to water is 1:4-6, and the time for the secondary decoction is 15-25 min.

[0018] Preferably, the mass ratio of the mixture to the ethanol solution in step (5) is 1:4-6, the soaking time in step (5) is 30-40 min, and the decoction time in step (5) is 18-22 min.

[0019] Preferably, the density of the extract in step (6) is 1.2-1.3 g / cm 3 .

[0020] The invention also provides application of the traditional Chinese medicine composition in preparing products for treating rheumatism.

[0021] The present invention provides a Chinese medicine composition for treating rheumatism and a preparation method thereof. The Chinese medicine composition comprises the following raw materials in parts by weight: 8-12 parts of safflower, 8-12 parts of selaginella, 8-12 parts of siler, 13-17 parts of atractylodes, 18-22 parts of radix spatholobi, 18-22 parts of striata herba, 8-12 parts of cassia twig, 2-4 parts of asarum, 13-17 parts of gentiana macrophylla, 8-12 parts of ligusticum chuanxiong, 13-17 parts of papaya, 8-12 parts of frankincense, 8-12 parts of myrrh, 8-12 parts of aconite, 8-12 parts of cibotium barometz, 8-12 parts of notopterygium wilfordii, and 4-6 parts of scorpion. The Chinese medicine composition of the present invention can effectively treat rheumatism, has a significant effect, and relieves pain quickly. DETAILED DESCRIPTION

[0022] The invention provides a traditional Chinese medicine composition for treating rheumatism. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 8-12 parts of safflower, 8-12 parts of selaginella, 8-12 parts of siler, 13-17 parts of atractylodes, 18-22 parts of radix spatholobi, 18-22 parts of herba lycopodii, 8-12 parts of cassia twig, 2-4 parts of asarum, 13-17 parts of gentiana macrophylla, 8-12 parts of ligusticum chuanxiong, 13-17 parts of papaya, 8-12 parts of frankincense, 8-12 parts of myrrh, 8-12 parts of aconite, 8-12 parts of cibotium barometz, 8-12 parts of notopterygium wilfordii and 4-6 parts of scorpion.

[0023] In the present invention, the Chinese medicine composition includes the following raw materials in parts by weight: 10 parts of safflower, 10 parts of Selaginella, 10 parts of Saposhnikovia, 15 parts of Atractylodes, 20 parts of Radix Penicillae, 20 parts of Herba Lycopodii, 10 parts of Cassia twig, 3 parts of Asarum, 15 parts of Gentiana macrophylla, 10 parts of Rhizoma Chuanxiong, 15 parts of Papaya, 10 parts of frankincense, 10 parts of myrrh, 10 parts of Aconite, 10 parts of Cibotium barometz, 10 parts of Notopterygium wilfordii, and 5 parts of Scorpio.

[0024] The present invention also provides a method for preparing the Chinese medicine composition, comprising the following steps:

[0025] (1) Weigh safflower, selaginella, siler, atractylodes, radix scutellariae, herba schizonepetae, herba cassiae, cassia twig, asarum, gentiana macrophyllae, rhizoma chuanxiong, papaya, frankincense, myrrh, aconite, cibotium barometz, notopterygium wilfordii, and scorpion according to proportion and set aside;

[0026] (2) crushing and mixing Selaginella, Saposhnikovia divaricata, Atractylodes macrocephala, Lycopodiella cuneata, Cinnamomum cassia, Asarum, Gentiana macrophylla, Ligusticum chuanxiong, Chaenomeles sinensis, Olibanum, Myrrha, Cibotium barometz and Notopterygium wilfordii to obtain a raw material powder;

[0027] (3) soaking the raw material powder in water and then boiling it to separate and obtain a filter residue and a filtrate 1;

[0028] (4) adding water to the filter residue and boiling it twice to separate and obtain filtrate 2;

[0029] (5) mixing safflower, radix polygoni lobatae, scorpion and aconite root to obtain a mixture, soaking in ethanol solution, decocting, and filtering to obtain filtrate 3;

[0030] (6) combining filtrate 1, filtrate 2 and filtrate 3, and concentrating them into an extract to obtain the Chinese medicine composition.

[0031] In the present invention, the particle size of the raw material powder in step (2) is preferably 40 to 60 meshes, more preferably 50 meshes.

[0032] In the present invention, the mass ratio of the raw material powder to water in step (3) is preferably 1:10-15, more preferably 1:12-13, the soaking temperature is preferably 30-40°C, more preferably 35°C, the soaking time is preferably 40-60min, more preferably 50min, and the decoction time is preferably 30-40min, more preferably 35min.

[0033] In the present invention, the mass ratio of the filter residue to water in step (4) is preferably 1:4-6, more preferably 1:5, and the time for the secondary decoction is preferably 15-25 min, more preferably 20 min.

[0034] In the present invention, the mass ratio of the mixture to the ethanol solution in step (5) is preferably 1:4-6, more preferably 1:5, the soaking time in step (5) is preferably 30-40 min, more preferably 35 min, and the decoction time in step (5) is preferably 18-22 min, more preferably 20 min.

[0035] In the present invention, the density of the extract in step (6) is preferably 1.2 to 1.3 g / cm 3 , more preferably 1.25 g / cm 3 .

[0036] The invention also provides application of the traditional Chinese medicine composition in preparing products for treating rheumatism.

[0037] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0038] Example 1

[0039] A method for preparing a Chinese medicine composition for treating rheumatism comprises the following steps:

[0040] (1) Weigh the raw materials according to the mass ratio of 12 parts of safflower, 8 parts of selaginella, 8 parts of siler, 17 parts of atractylodes, 22 parts of scutellaria, 18 parts of lycopodiella ciliata, 8 parts of cassia twig, 2 parts of asarum, 17 parts of gentiana macrophylla, 12 parts of ligusticum, 13 parts of papaya, 12 parts of frankincense, 8 parts of myrrh, 8 parts of aconite, 8 parts of cibotium barometz, 8 parts of notopterygium wilfordii, and 6 parts of scorpion, and set aside;

[0041] (2) grinding Selaginella, Saposhnikovia divaricata, Atractylodes lancea, Lycopodiella cuneata, Cinnamomum cassia, Asarum, Gentiana macrophylla, Ligusticum chuanxiong, Chaenomeles sinensis, Olibanum incense, Myrrha myrrh, Cibotium barometz and Notopterygium wilfordii into 60 meshes and mixing them to obtain a raw material powder;

[0042] (3) adding 10 times the weight of water to the raw material powder, soaking for 40 min at 40° C., then boiling for 30 min, and separating to obtain a filter residue and a filtrate 1;

[0043] (4) adding 6 times the weight of water to the filter residue and boiling it for 15 min to obtain filtrate 2;

[0044] (5) Mix safflower, radix polygoni lobatae, scorpion and aconite to obtain a mixture, add 4 times the mass of ethanol solution, soak for 40 minutes, decoct for 18 minutes, and filter to obtain filtrate 3;

[0045] (6) Combine filtrate 1, filtrate 2 and filtrate 3 and concentrate to a density of 1.3 g / cm 3 to obtain the Chinese medicine composition.

[0046] Example 2

[0047] A method for preparing a Chinese medicine composition for treating rheumatism comprises the following steps:

[0048] (1) Weigh the raw materials according to the mass ratio of 8 parts of safflower, 12 parts of selaginella, 12 parts of siler, 13 parts of atractylodes, 18 parts of scutellaria, 22 parts of lycopodiella ciliata, 12 parts of cassia twig, 4 parts of asarum, 13 parts of gentiana macrophylla, 8 parts of ligusticum chuanxiong, 17 parts of papaya, 8 parts of frankincense, 12 parts of myrrh, 12 parts of aconite, 12 parts of cibotium barometz, 12 parts of notopterygium wilfordii, and 4 parts of scorpion, and set aside;

[0049] (2) grinding Selaginella, Saposhnikovia divaricata, Atractylodes lancea, Lycopodiella cuneata, Cinnamomum cassia, Asarum, Gentiana macrophylla, Ligusticum chuanxiong, Chaenomeles sinensis, Olibanum incense, Myrrha myrrh, Cibotium barometz and Notopterygium wilfordii into 40 meshes and mixing them to obtain a raw material powder;

[0050] (3) adding 15 times the weight of water to the raw material powder, soaking for 60 min at 30° C. and then boiling for 30 min, and separating to obtain a filter residue and a filtrate 1;

[0051] (4) adding 4 times the weight of water to the filter residue and boiling it for 25 min to obtain filtrate 2;

[0052] (5) Mix safflower, radix polygoni lobatae, scorpion and aconite to obtain a mixture, add 6 times the mass of ethanol solution, soak for 30 minutes, decoct for 22 minutes, and filter to obtain filtrate 3;

[0053] (6) Combine filtrate 1, filtrate 2 and filtrate 3 and concentrate to a density of 1.2 g / cm 3 to obtain the Chinese medicine composition.

[0054] Example 3

[0055] A method for preparing a Chinese medicine composition for treating rheumatism comprises the following steps:

[0056] (1) Weigh the raw materials according to the mass ratio of 10 parts of safflower, 10 parts of selaginella, 10 parts of siler, 15 parts of atractylodes, 20 parts of scutellaria, 20 parts of lycopodiella cuneata, 10 parts of cassia twig, 3 parts of asarum, 15 parts of gentiana macrophylla, 10 parts of ligusticum chuanxiong, 15 parts of papaya, 10 parts of frankincense, 10 parts of myrrh, 10 parts of aconite, 10 parts of cibotium barometz, 10 parts of notopterygium wilfordii, and 5 parts of scorpion, and set aside;

[0057] (2) grinding Selaginella, Saposhnikovia divaricata, Atractylodes lancea, Lycopodiella cuneata, Cinnamomum cassia, Asarum, Gentiana macrophylla, Ligusticum chuanxiong, Chaenomeles sinensis, Olibanum incense, Myrrha myrrh, Cibotium barometz and Notopterygium wilfordii into 50 meshes and mixing them to obtain a raw material powder;

[0058] (3) adding 13 times the weight of water to the raw material powder, soaking for 50 min at 35° C. and then boiling for 35 min, and separating to obtain a residue and a filtrate 1;

[0059] (4) adding 5 times the weight of water to the filter residue and boiling it for 20 min to obtain filtrate 2;

[0060] (5) Mix safflower, radix polygoni lobatae, scorpion and aconite to obtain a mixture, add 5 times the mass of ethanol solution to soak for 35 minutes, then boil for 20 minutes, and filter to obtain filtrate 3;

[0061] (6) Combine filtrate 1, filtrate 2 and filtrate 3 and concentrate to a density of 1.25 g / cm 3 to obtain the Chinese medicine composition.

[0062] Test example

[0063] Fifty SD rats weighing 205±10g were selected and divided into experimental groups 1 to 3 and control groups 1 to 2, with 10 rats in each group. Bovine type II collagen was used to induce rheumatoid arthritis models in the rats in experimental groups 1 to 3 and control group 1, and no induction was performed on the rats in control group 2. When the joints of the rats in experimental groups 1 to 3 and control group 1 were red and swollen and they had difficulty in moving, the model induction was completed.

[0064] After the model induction was completed, the rats in the test group 1 were fed with the Chinese medicine composition prepared in Example 1, the rats in the test group 2 were fed with the Chinese medicine composition prepared in Example 2, and the rats in the test group 3 were fed with the Chinese medicine composition prepared in Example 3. The feeding amount of each group of rats was 0.09 g / d / rat, and the rats in the control groups 1 to 2 were not fed with additional Chinese medicine compositions. During the experiment, the rats in each group were free to eat and drink water, and the experiment was carried out for a total of 28 days. After the experiment, the therapeutic effect of each group of rats was observed, and the results are shown in Table 1.

[0065] Table 1

[0066] Group get well Improvement invalid Experimental Group 1 9 1 0 Experimental Group 2 7 3 0 Experimental Group 3 8 2 0

[0067] Note:

[0068] The criteria for recovery are: the redness and swelling of the rat joints completely disappear, and the animal's mobility is not significantly different from that of the rats in the control group 2;

[0069] The criteria for improvement were: the redness and swelling of the rats' joints decreased, and the animals' mobility was close to that of the rats in control group 2 and better than that of the rats in control group 1;

[0070] The invalidity criterion is: the rats' joint symptoms and mobility are not significantly different from those of the rats in the control group 1.

[0071] As can be seen from the above embodiments, the present invention provides a Chinese medicine composition for treating rheumatism and a preparation method thereof. The Chinese medicine composition comprises the following raw materials in parts by weight: 8-12 parts of safflower, 8-12 parts of selaginella, 8-12 parts of siler, 13-17 parts of atractylodes, 18-22 parts of scutellaria, 18-22 parts of striata, 8-12 parts of cassia twig, 2-4 parts of asarum, 13-17 parts of gentiana, 8-12 parts of chuanxiong, 13-17 parts of papaya, 8-12 parts of frankincense, 8-12 parts of myrrh, 8-12 parts of aconite, 8-12 parts of cibotium barometz, 8-12 parts of notopterygium, and 4-6 parts of scorpion. The Chinese medicine composition of the present invention can effectively treat rheumatism, has a significant effect, and relieves pain quickly.

[0072] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating rheumatism, characterized in that: The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 8-12 parts of safflower, 8-12 parts of selaginella, 8-12 parts of siler, 13-17 parts of atractylodes, 18-22 parts of radix spatholobi, 18-22 parts of herba lycopodii, 8-12 parts of cassia twig, 2-4 parts of asarum, 13-17 parts of gentiana macrophylla, 8-12 parts of ligusticum chuanxiong, 13-17 parts of papaya, 8-12 parts of frankincense, 8-12 parts of myrrh, 8-12 parts of aconite, 8-12 parts of cibotium barometz, 8-12 parts of notopterygium wilfordii, and 4-6 parts of scorpion.

2. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition comprises the following raw materials in parts by weight: 10 parts of safflower, 10 parts of selaginella, 10 parts of siler, 15 parts of atractylodes, 20 parts of radix spatholobi, 20 parts of herba lycopodii, 10 parts of cassia twig, 3 parts of asarum, 15 parts of gentiana macrophylla, 10 parts of rhizoma ligustici, 15 parts of papaya, 10 parts of frankincense, 10 parts of myrrh, 10 parts of aconite, 10 parts of cibotium barometz, 10 parts of notopterygium wilfordii, and 5 parts of scorpion.

3. The method for preparing the Chinese medicine composition according to claim 1 or 2, characterized in that: The steps include: (1) Weigh safflower, selaginella, siler, atractylodes, radix scutellariae, herba schizonepetae, herba cassiae, cassia twig, asarum, gentiana macrophyllae, rhizoma chuanxiong, papaya, frankincense, myrrh, aconite, cibotium barometz, notopterygium wilfordii, and scorpion according to proportion and set aside; (2) crushing and mixing Selaginella, Saposhnikovia divaricata, Atractylodes macrocephala, Lycopodiella cuneata, Cinnamomum cassia, Asarum, Gentiana macrophylla, Ligusticum chuanxiong, Chaenomeles sinensis, Olibanum, Myrrha, Cibotium barometz and Notopterygium wilfordii to obtain a raw material powder; (3) soaking the raw material powder in water and then boiling it to separate and obtain a filter residue and a filtrate 1; (4) adding water to the filter residue and boiling it twice to separate and obtain filtrate 2; (5) mixing safflower, radix polygoni lobatae, scorpion and aconite root to obtain a mixture, soaking in ethanol solution, decocting, and filtering to obtain filtrate 3; (6) combining filtrate 1, filtrate 2 and filtrate 3, and concentrating them into an extract to obtain the Chinese medicine composition.

4. The preparation method according to claim 3, characterized in that: The particle size of the raw material powder in step (2) is 40 to 60 meshes.

5. The preparation method according to claim 4, characterized in that: In step (3), the mass ratio of the raw material powder to water is 1:10-15, the soaking temperature is 30-40°C, the soaking time is 40-60 minutes, and the decoction time is 30-40 minutes.

6. The preparation method according to claim 5, characterized in that: In step (4), the mass ratio of the filter residue to water is 1:4-6, and the time of the secondary decoction is 15-25 minutes.

7. The preparation method according to claim 6, characterized in that: The mass ratio of the mixed material to the ethanol solution in step (5) is 1:4-6, the soaking time in step (5) is 30-40 minutes, and the decoction time in step (5) is 18-22 minutes.

8. The preparation method according to claim 3, characterized in that: The density of the extract in step (6) is 1.2-1.3 g / cm 3 .

9. Use of the Chinese medicine composition according to claim 1 or 2 in preparing a product for treating rheumatism.