Fluxazole amide composition and preparation method thereof

Abstract

The present invention relates to a fluoxazole amide composition that provides synergistic control of insect pests and mites under one-time application, and a method for preparing the same. More specifically, the present invention relates to a synergistic composition having a fluoxazole amide or an agrochemically acceptable salt thereof, at least one or more compounds selected from insecticides, at least one or more compounds selected from plant health additives, and a process for preparing said composition, and an agrochemically acceptable excipient. The invention also relates to a pesticidal composition which improves the health, yield, vigor, quality and tolerance to abiotic or biological stress of treated plants, prevents lodging of susceptible plants due to biological and abiotic factors such as heavy rain, wind, insects and disease damage, and also improves the yield, vigor, quality and tolerance to abiotic or biological stress. And provides residue control (i.e., longer duration control) and direct crop protection as well as effective control of insects and mites that are difficult to kill and have drug resistance.

Description

Technical Field

[0001] The present invention relates to a fluxametamide composition and a method for preparing the same. More specifically, the present invention relates to an insecticidal composition and a method for preparing the composition, the insecticidal composition comprising a biologically active amount of fluxametamide or an agrochemically acceptable salt thereof, at least one or more compounds selected from insecticides, at least one or more compounds selected from plant health additives, and an agrochemically acceptable excipient. The present invention also relates to an insecticidal composition that improves the health, yield, vitality, quality and tolerance to abiotic or biotic stresses of treated plants. In addition, the present invention provides synergistic control of insect pests and mites under a one-time application. Background Art

[0002] The challenge of growing enough food to feed the world’s growing population, coupled with changing eating habits among an expanding middle class throughout Asia, has prompted a demand for improving crop yields and quality by controlling a variety of insect pests.

[0003] Insecticides are pesticides formulated to kill, injure, repel or slow down one or more insects. Insecticides work in different ways. Some insecticides damage the nervous system, while others may damage their exoskeleton, repel them or control them by some other means. The mode of action of insecticides is classified by the Insecticide Resistance Action Committee (IRAC). In this classification, a large part of insecticides are classified as nerve and muscle targeting insecticides, which include GABACl antagonists (Group 2) and GluCl allosteric modulators (Group 6).

[0004] The advent of synthetic pesticides in the mid-20th century made control of insects and other arthropod pests more effective, and such chemicals remain essential in modern agriculture. By preventing crop losses, improving the quality of produce, and reducing the cost of farming, modern pesticides increased crop yields by as much as 50% in some parts of the world between 1945 and 1965.

[0005] In recent years, a new chemical type of GABACl antagonists, the isoxazolines, has been reported. Isoxazolines are 5-membered heterocycles that are present in the active compounds of many commercial veterinary anti-ectoparasite products. The molecular target of isoxazolines is to inhibit GABA-gated chloride channels in insects.

[0006] The main problem with pesticides, however, is that some target insect populations have a tendency to develop resistance because their susceptible members are killed, and those resistant strains that survive may eventually multiply and form the majority of the population. Resistance means that a previously susceptible insect population can no longer be controlled with the pesticide in the amounts normally recommended. Hundreds of harmful insects have acquired resistance to different synthetic organic pesticides, and strains that become resistant to one pesticide may also become resistant to a second pesticide that works in a similar way to the first. Once resistance has developed, it tends to persist in the absence of pesticides for varying lengths of time, depending on the type of resistance and the species of pest.

[0007] Combinations of insecticides are used to expand the spectrum of insect control, improve pest control with synergistic effects, reduce dosages and thus reduce environmental impact, expand the spectrum of control, reduce the potential for resistance development, and enhance residual control, thereby reducing the number of spraying applications for crop protection and minimizing the insecticide load on the ecosystem.

[0008] Due to the problems associated with the heavy use of some chemical pesticides, current insect control practices combine their use with biological methods in an approach known as integrated control. Further combinations of insecticides with plant-beneficial compounds are becoming increasingly popular with farmers. On the one hand, it kills insects; on the other hand, it provides crop nutrients, thus solving the problem of pest control and growth promotion.

[0009] Agricultural biostimulants are blends of compounds, substances and microorganisms that are sprayed on plants or soil to improve the vigor, yield, quality and tolerance of crops to abiotic stresses. Biostimulants promote plant growth and development in a variety of ways throughout the crop life cycle, from seed germination to maturity. Biostimulants work through different mechanisms than fertilizers, regardless of the presence of nutrients in the product. Biostimulants are different from crop protection products because they work best on the vigor of plants without any direct effect on pests or diseases. Therefore, crop biostimulation is a supplement to crop nutrition and crop protection. Plant growth regulators are defined as small and simple chemicals produced naturally by plants to regulate their growth and development. Plant growth regulators (PGRs) are molecules that affect plant development and are usually active at very low concentrations. There are natural regulators produced by the plants themselves, as well as synthetic regulators; those found naturally in plants are called phytohormones or plant hormones.

[0010] CN103102224A relates to an insecticide-fertilizer composition, which contains benfuracarb, pectin oligosaccharides and fertilizer components, wherein the fertilizer component contains macronutrients and trace nutrients; the macronutrients are selected from any one or more of urea, ammonium nitrate, ammonium bicarbonate, potassium chloride, potassium dihydrogen phosphate, sodium dihydrogen phosphate and ammonium phosphate; the trace nutrients are selected from any one or more of boric acid, borax, manganese sulfate, zinc sulfate, copper sulfate, ammonium molybdate and ferrous sulfate.

[0011] CN107512959A relates to a fertilizer specially used for taming Bletilla striata tissue culture seedlings, and its preparation method and application, and the fertilizer is used to prevent and control underground insect invasion. The fertilizer is prepared from the following raw materials in parts by weight: 10 to 20 parts of Radix Sophorae flavescentis, 20 to 30 parts of Melia azedarach, 5 to 10 parts of potassium humate, 15 to 20 parts of Camellia oleifera cake, 1 to 5 parts of plant growth regulator, 80 to 120 parts of sheep manure, 100 to 150 parts of silkworm excrement, and 5 to 10 parts of biological fermentation bacteria.

[0012] CN1478761A relates to a multifunctional fertilizer, which contains trace elements, pesticides, long-acting agents, biological agents, plant growth promoters and plant growth regulators, wherein the trace elements can be zinc sulfate, manganese sulfate, ferrous sulfate, magnesium sulfate, copper sulfate, boric acid or borax, ammonium molybdate, silicon powder, and the plant growth promoter can be vitamin B1, vitamin B6, nicotinamide or gibberellin.

[0013] However, these combinations need to be improved. There is a need in the art for a combination that reduces the potential for resistance, improves the spectrum of disease and pest control, and also improves the health, yield, vigor, quality and tolerance to abiotic or biotic stresses of the treated plants. Summary of the invention

[0014] Purpose of the invention

[0015] The main object of the present invention is to provide a fluoxetine oxadiazole composition and a process for its preparation which provides synergistic control of insect pests and mites in a single application.

[0016] Another object of the present invention is to provide a fluoxetine amide composition and a method for preparing the composition, wherein the fluoxetine amide composition comprises a biologically active amount of fluoxetine amide or an agrochemically acceptable salt thereof, at least one or more compounds selected from pesticides, at least one or more compounds selected from plant health additives, and an agrochemically acceptable excipient.

[0017] Another object of the present invention is to provide a fluazifop-butyl composition that produces residual control (ie, longer lasting control) and directly protects crops.

[0018] It is a further object of the present invention to provide a fluoxetine composition which delays the development of resistance and provides effective control of hard-to-kill and resistant insect pests and mites.

[0019] Yet another object of the present invention is to provide a fluoxathiazide composition which increases the yield of treated plants (cereals, legumes, oilseeds, fiber crops, sugar crops, leafy vegetables, tuber crops, fruit crops, flowers, ornamental plants, etc.).

[0020] Yet another object of the present invention is to provide a fluoxetine composition which allows increased yield due to protection against insect pests and mites.

[0021] Yet another object of the present invention is to provide a fluoxetine composition which results in increased yield due to plant growth regulation and increased reproductive parts of the plant.

[0022] Yet another object of the present invention is to provide a fluoxetine composition which results in increased yield due to more tillering number, more branches and sub-branches, more number of flowers and more number of fruits.

[0023] Another object of the present invention is to provide a fluoxetine composition that increases plant vigor.

[0024] It is yet another object of the present invention to provide fluoxetine compositions having increased tolerance to damage by insect pests and mites.

[0025] Yet another object of the present invention is to provide a fluoxetine composition having increased tolerance to weather stress and water stress.

[0026] Yet another object of the present invention is to provide a fluoxetine composition for preventing lodging of susceptible plants due to biotic and abiotic factors such as heavy rain, wind, insect and disease damage.

[0027] Yet another object of the present invention is to provide a fluoxetine composition that improves the quality (meaning visual appearance, color, size, shape, etc.) of grains, fruits, fibers, flowers, tubers, bulbs, rhizomes, straw, leaves and other plant parts and plant products.

[0028] It is yet another object of the present invention to provide a fluoxetine composition that improves the keeping properties of agricultural products, extends the post-harvest life and storage period, and protects against post-harvest diseases.

[0029] It is a further object of the present invention to provide a fluoxetine composition that aids in the homogenization of the size of tubers, bulbs, rhizomes and root crops.

[0030] A further object of the present invention is to provide a method for preparing a stable and non-phytotoxic formulation.

[0031] Summary of the Invention

[0032] The present invention provides a synergistic insecticidal composition and a method for preparing the composition. The insecticidal composition comprises a biologically active amount of (A) fluoxetine or an agrochemically acceptable salt thereof, (B) at least one or more compounds selected from insecticides, (C) at least one or more compounds selected from plant health additives, and an agrochemically acceptable excipient.

[0033] The formulation of the insecticide composition is selected from capsule suspension (CS), emulsifiable concentrate (EC), water-in-oil emulsion (EO), oil-in-water emulsion (EW), Jambo ball or bag (bag in water-soluble bag), microemulsion (ME), oil dispersion (OD), oil miscible flowable concentrate (Oil miscible suspension, OF), oil miscible liquid (Oil miscible liquid, OL), suspension concentrate (SC), suspo-emulsion (SE), soluble concentrate (SL), wettable granule / water dispersible granule (WG / WDG), water soluble granule (SG), water soluble powder (Water The invention relates to a kind of preparations of the present invention and the invention relates to a kind of preparations of the present invention. The preparations include soluble powder (SP), wettable powder (WP), a mixture of CS and SC (ZC), a mixture of CS and SE (ZE), a mixture of CS and EW (ZW), granules (GR) / soil applied granules (SAG) and controlled release granules (CR).

[0034] Those skilled in the art can modify the method for preparing the novel synergistic composition accordingly based on the knowledge of manufacturing formulations. However, all these changes and modifications are still included in the scope of the present invention.

[0035] The present invention provides fluoxazolidinone compositions that provide synergistic control of insect pests and mites in a single application. In addition, the compositions of the present invention improve the health, yield, vigor, quality and tolerance to abiotic or biotic stresses of the treated plants, and prevent lodging of susceptible plants caused by biotic and abiotic factors such as heavy rain, wind, insect and disease damage. In addition, the present invention provides residual control (i.e., control of longer duration) and direct crop protection as well as effective control of difficult-to-kill and resistant insect pests and mites. DETAILED DESCRIPTION

[0036] Before describing the present invention in detail, it should be understood that the present invention is not limited to the details of the parts shown in its application. The present invention can have other embodiments as described above and can be practiced or implemented in various ways. It should be understood that the wording and terminology used in this article are for description and not limitation. The present invention can have various embodiments, which can be implemented as described in the following pages of the complete specification.

[0037] The terms and words used in the following description are not limited to the bibliographical meanings, but are only used by the inventor to enable the present invention to be clearly and consistently understood. Therefore, it should be apparent to those skilled in the art that the following description of the exemplary embodiments of the present invention is provided only for the purpose of illustration, rather than for the purpose of limiting the scope of the present invention.

[0038] It is to be understood that the singular forms "a," "an," and "the" include plural references unless the context clearly dictates otherwise.

[0039] Features described and / or illustrated with respect to one embodiment may be used in the same or similar manner in one or more other embodiments and / or in combination with or in place of features of other embodiments.

[0040] It should be emphasized that the term "include / comprises" when used in this specification is used to illustrate the existence of the described features, steps or components, but does not exclude the existence or addition of one or more other features, steps, components or combinations thereof.

[0041] The term "plant" as used herein refers to all physical parts of a plant, including seeds, seedlings, saplings, roots, tubers, stems, branches, leaves and fruits. The term "plant" is understood to include wild-type plants and plants that have been modified by conventional breeding or mutation formation or genetic engineering or a combination thereof.

[0042] The term "crop" refers to both growing crops and harvested crops.

[0043] As used herein, the term "insect" includes all organisms in the class "Insecta".

[0044] The term "animal pest" includes arthropods, gastropods and nematodes. Preferred animal pests according to the present invention are arthropods, preferably insects and arachnids, especially insects. Insects that are particularly associated with crops are generally referred to as crop insect pests.

[0045] As used herein, the term "insecticide" refers to the ability of an insecticide to increase insect mortality or inhibit insect growth rate.

[0046] "Controlling" or "inhibiting" pests means inhibiting the ability of pests to survive, grow, feed and / or reproduce, or limiting pest-related damage or losses in crop plants by toxic effects. "Controlling" pests may or may not mean killing the pests, although preferably it means killing the pests.

[0047] The term "plant health" or "plant health" is defined as the condition of a plant and / or its products. As a result of improved health, yield, plant vigor, quality and tolerance to abiotic or biotic stresses are increased.

[0048] "Yield" is to be understood as any economically valuable plant product produced by a plant, such as cereals, fruits in the proper sense, vegetables, nuts, grains, seeds, wood (e.g. in the case of afforestation plants) or even flowers (e.g. in the case of horticultural plants, ornamental plants).

[0049] "Increased yield" of plants, especially agricultural, silvicultural and / or horticultural plants, means that the yield of a product of the corresponding plant is increased by a measurable amount compared to the yield of the same product produced by the plant under the same conditions but without application of the composition of the invention.

[0050] The present invention provides a synergistic insecticidal composition comprising

[0051] 1. Compound A - oxazolidinone or its agrochemically acceptable salt,

[0052] 2. Compound B—at least one or more compounds selected from the group consisting of insecticides,

[0053] 3. Compound C—at least one or more compounds selected from plant health additives,

[0054] The mass percentages of the compositions are as follows:

[0055] Serial number Element Concentration range (%w / w) 1. Compound A 1 to 40 2. Compound B 1 to 40 3. Compound C 0.001 to 20

[0056] Fluoxazolamide, 4-((5RS)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)isoxazol-3-yl)-N-((EZ)-(methoxyimino)methyl)-o-toluamide is a new broad-spectrum insecticide discovered and synthesized by Nissan Chemical Industries, Ltd. It belongs to a class of compounds known as isoxazolines, which are potent inhibitors of gamma-aminobutyric acid (GABA)-gated chloride channels, glutamate-gated chloride channels, and glycine-gated chloride channels in insects and exhibit high insecticidal activity against a variety of insect species such as Lepidoptera, Thysanoptera, Acarina, and Diptera.

[0057]

[0058] Fluoxathiazide is a broad-spectrum isoxazoline insecticide that is effective against a variety of pests. It is mainly used to control lepidopteran insect pests, thrips, whiteflies, leafminers, beetles and mites on crops such as fruit trees, vegetables, soybeans, cotton and tea trees.

[0059] The carbamate insecticide (AChE-acetylcholinesterase inhibitor) used for compound B is selected from carbaryl, carbofuran, carbosulfan, methomyl, oxamyl, pirimicarb and thiodicarb; the organophosphate insecticide (AChE-acetylcholinesterase inhibitor) is selected from acephate, cadusafos, chlorpyrifos, chlorpyrifos-methyl, demeton-S-methyl, dimethoate, ethion, fenamiphos, fenitrothion, fenthion, fosthiazate, Methamidophos, monocrotophos, oxydemeton-methyl, parathion, parathion-methyl, phenthoate, phorate, phosalone, phosphamidon, profenofos, quinalphos and triazophos; phenylpyrazoles-fiproles (GABA-gated chloride channel blockers) selected from ethiprole, fipronil, flufiprole, nicofluprole, pyrafluprole and pyriprole;Pyrethroid insecticides (sodium channel modulators) are selected from bifenthrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, -cypermethrin), theta-cypermethrin, zeta-cypermethrin, cyphenothrin, deltamethrin, fenpropathrin, fenvalerate, tau-fluvalinate, permethrin, phenothrin, prallemethrin thrin), profluthrin and pyrethrin (pyrethrum); nicotinic insecticides (competitive modulators of nicotinic acetylcholine receptors (nAChR)) selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam, Flupyrimin, cycloxaprid, paichongding, guadipyr, cycloxylidin; sulfonimides (sulfoxaflor); butenolides (flupyradifurone); meso-ions (triflumezopyrim, dichloromezotiaz, and fenmezoditiaz);Nereistoxin analog insecticides (nicotinic acetylcholine receptor (nAChR) channel blockers) selected from bensultap, monosultap, cartap hydrochloride, thiocyclam, thiocyclam hydrogen oxalate, thiocyclam hydrochloride and thiosultap sodium); spinosyn insecticides (nicotinic acetylcholine receptor (nAChR) allosteric modulators - site I) selected from spinosad and spinetoram; avermectin and milbemycin insecticides (glutamate-gated chloride channel (GluCl) allosteric modulators) selected from avermectins (abamectin, emamectin benzoate, benzoate, ivermectin, lepimectin and milbemycins (milbemectin); biomimetic juvenile hormone insecticides selected from hydroprene, kinoprene, methoprene, fenoxycarb and pyriproxyfen; non-specific multi-site inhibitor insecticides selected from chloropicrin , dazomet and metam; the chord organ modulator insecticide is selected from pymetrozine, pyrifluquinazon, afidopyropen and flonicamid; the CHSI-affecting mite growth inhibitor insecticide is selected from clofentezine, hexythiazox, diflovidazin or etoxazole;The benzoylurea insecticide (inhibitor of chitin biosynthesis affecting CHSI) is selected from bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron and triflumuron; the thiazolinone insecticide (inhibitor of chitin biosynthesis type 1) is selected from thiazolinone; the cyromazine insecticide (molting disruptor for dipteran insects) is selected from cyromazine; the insecticide of microbial disruptors of insect midgut membrane is selected from Bacillus thuringiensis. thuringiensis and the insecticidal proteins produced by them; uncouplers of oxidative phosphorylation selected from chlorfenapyr, DNOC or sulfluramid; dihydrazide insecticides (ecdysone receptor agonists) selected from dihydrazides (methoxyfenozide, tebufenozide, halofenozide, fufenozide or chromafenozide); octopamine receptor agonists (octopamin The mitochondrial ATP synthase inhibitor is selected from diafenthiuron, azocyclotin, cyhexatin, fenbutatinoxide, propargite or tetradifon; the METI (mitochondrial complex I) inhibitor is selected from fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad, flufenerim, rotenone, fluacrypyrim and pyriminostrobin; METI (mitochondrial complex II) inhibitor insecticides selected from cyenopyrafen, cyflumetofen and pyflubumide;The METI (mitochondrial complex III) inhibitor insecticide is selected from hydramethylnon, acequinocyl, fluacrypyrim, bifenazate and flometoquin; the METI (mitochondrial complex IV) inhibitor insecticide is selected from phosphides and cyanides; the voltage-dependent sodium channel blocker insecticide is selected from indoxacarb and metaflumizone; the lipid synthesis inhibitor The inhibitor (inhibitor of acetyl CoA carboxylase) class insecticide is selected from spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion or spirobudifen; the baculovirus class insecticide is selected from granulovirus and nucleopolyhedrosis virus. virus; calcium-activated potassium channel (KCa2) modulator insecticides selected from acynonapyr; compounds with unknown or undefined modes of action selected from azadirachtin, benzoximate, bromopropylate, benzpyrimoxan, chinomethionat, dicofol, pyridalyl, oxazosulfyl, dimpropyridaz, indazapyroxamet, tiorantraniliprole, acaricide compounds fluhexafon, cyetpyrafen, flupentiofenox, acyonapyr, trifluenfuronate, cyclobutrifluram, fluazaindolizine and tioxazafen. ;

[0060] The plant health additives of the biostimulant group of compound C are selected from humic acid and salts, fulvic acid and salts, amino acids (alanine, arginine, aspartic acid, cysteine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine or mixtures thereof), kojic acid, protein hydrolysate, carboxylic acid, jasmonic acid, methyl jasmonate, chitosan, chitin, alginate, cyclodextrin, thiabendazole, acibenzolar-S-methyl, kelp polysaccharide, seaweed extract (Ascophyllum nodosum nodosum), polyamines, silicic acid and salts - orthosilicic acid (H4SiO4), salicylic acid, lactic acid, phenyllactic acid, fumaric acid, nitrobenzene, stigmasterol, campesterol, brassinolide (homo), forchlorfenuron, triacontanol, nitrophenolates (sodium p-nitrophenolate, o-nitrophenolate, sodium-5-nitroguaiacolate) or mixtures thereof; plant health additives from the group of plant growth promoters / regulators selected from indoleacetic acid, indolebutyric acid, α-naphthylacetic acid, kinetin, zeatin, 6-benzylaminopurine, 6-benzyladenine, dipheylurea, thidiazuron, anisiflupurin, aviglycine, prohexadione, prohexadione calcium (prohexadione calcium), trinexapac, trinexapac-ethyl, aminoethoxyethyleneglycine (AVG), gibberelline-gibberellic acid (GA3), abscisic acid, chlorpropham, flumetralin, maleic hydrazide, mepiquat, mepiquat chloride, mepiquat pentaborate, chlormequat, chlormequat chloride, paclobutrazol, uniconazole-P or a mixture thereof;The plant health additive of the micronutrient group is selected from zinc (zinc sulfate heptahydrate, zinc sulfate monohydrate, Zn-EDTA, zinc oxide, zinc lactate gluconate, zinc polyflavonoid), ferrous sulfate, copper sulfate, manganese sulfate, boron (borax-sodium tetraborate, boric acid (H3BO3), disodium octaborate tetrahydrate (Na2B8O; 13 .4H2O), disodium tetraborate pentahydrate, anhydrous borax) and sulfur (elemental sulfur, bentonite sulphur, borated sulfur or sulfates and thiosulfates) or mixtures thereof.

[0061] The present invention optionally includes agrochemically acceptable excipients, including but not limited to dispersants, antifreeze agents, defoamers, wetting agents, suspension aids and carriers, antimicrobial agents, thickeners, colorants, quick coating agents or adhesives (also known as "stickers" or "binders"), polymers, disintegrants, oil additives, buffers and solvents.

[0062] The surfactant used as a dispersant has the ability to strongly adsorb on the surface of the particles and provides a charged or spatial barrier for particle reaggregation. The most commonly used surfactants are anionic surfactants, nonionic surfactants, or mixtures of these two types. For wettable powder formulations, the most common dispersant is sodium lignin sulfonate. For suspension concentrates, polyelectrolytes (such as sodium naphthalene sulfonate formaldehyde condensates) are used to obtain very good adsorption and stability. Tristyryl phenol ethoxylate phosphate ester is also used. Nonionic surfactants such as alkyl aryl ethylene oxide condensates and EO-PO block copolymers are sometimes combined with anionic surfactants as dispersants for suspension concentrates. In recent years, new types of extremely high molecular weight polymer surfactants have been developed as dispersants. These polymer surfactants have very long hydrophobic "main chains" and a large number of ethylene oxide chains that form the "teeth" of "comb-like" surfactants. These high molecular weight polymers can provide very good long term stability for suspension concentrates because the hydrophobic backbone has many anchoring points to the particle surface. Dispersants used herein include, but are not limited to, sodium lignin sulfonate, sodium naphthalene sulfonate formaldehyde condensate, tristyrylphenol ethoxylate phosphate, fatty alcohol ethoxylate, alkyl ethoxylate, EO-PO block copolymer, graft copolymer or mixtures thereof.

[0063] The cryoprotectant used herein may be selected from polyethylene glycol, methoxypolyethylene glycol, polypropylene glycol, polybutylene glycol, glycerol and ethylene glycol.

[0064] Water-based formulations often cause foaming during the mixing operation of production. In order to reduce the tendency to foam, defoamers are usually added during the production stage or before filling into the bottle. Generally speaking, there are two types of defoamers, silicone and non-silicone. Silicones are usually aqueous emulsions of dimethyl polysiloxane, while non-silicone defoamers are water-insoluble oils (such as octanol and nonanol) or silica. In both cases, the role of the defoamer is to displace the surfactant from the air-water interface.

[0065] Wetting agents used in wettable powder, suspension concentrate and water dispersible granule formulations include, but are not limited to, sodium lauryl sulfate, sodium dioctyl sulpho-succinate, alkylphenol ethoxylates, fatty alcohol ethoxylates or mixtures thereof.

[0066] Suspension aids refer to natural or synthetic organic or inorganic materials that are combined with active substances to facilitate their application to plants, seeds or soil. It is usually inert and must be agriculturally acceptable, especially acceptable to the plants to be treated. The carrier can be solid and is selected from, but not limited to, diatomaceous earth, attapulgite or zeolite, dolomite, silica, fly ash, slaked lime, wheat flour, wood flour, ground wheat straw, cellulose and soy flour, bentonite, kaolin, calcium carbonate, talc, muscovite, fused sodium potassium, aluminum silicate, perlite, urea, sulfur-coated urea, isobutylidene diurea, ammonium nitrate, ammonium sulfate, ammonium phosphate, triple superphosphate, Phosphate), phosphoric acid, potassium sulfate, potassium nitrate, potassium metaphosphate, potassium chloride, dipotassium carbonate, potassium oxide and combinations of these substances; alternatively, the carrier may be a liquid and is selected from, but not limited to, water, toluene, xylene, petroleum ether, vegetable oil, acetone, methyl ethyl ketone, cyclohexanone, anhydride, acetonitrile, acetophenone, amyl acetate, 2-butanone, butylene carbonate, chlorobenzene, cyclohexane, cyclohexanol, alkyl acetate, diacetone alcohol, 1,2-dichloropropane, diethanolamine, p-diethylbenzene, diethylene glycol, diethylene glycol rosin acid ester, diethylene glycol butyl ether, diethylene glycol ethyl ether, diethylene glycol methyl ether, N,N-dimethylformamide, dimethyl sulfoxide, 1,4-dioxane, dipropylene glycol, dipropylene glycol methyl ether, dipropylene glycol dibenzoic acid Esters, diproxitol, alkyl pyrrolidone, ethyl acetate, 2-ethylhexanol, ethylene carbonate, 1,1,1-trichloroethane, 2-heptanone, α-pinene, d-limonene, ethyl lactate, ethylene glycol, ethylene glycol butyl ether, ethylene glycol methyl ether, γ-butyrolactone, glycerol, acetic acid glyceryl, diacetic acid glyceryl, triacetic acid glyceryl, hexadecane, hexanediol, isoamyl acetate, isobornyl acetate, isooctane, isophorone, isopropyl benzene, isopropyl myristate, lactic acid, laurylamine, mesityl oxide, methoxypropanol, methyl isoamyl ketone, methyl isobutyl ketone, methyl laurate, methyl octanoate, methyl oleate, dichloromethane, m-xylene, n-hexane, n-octylamine, octadecanoic acid, octylamine acetate acetate), oleic acid, oleylamine, o-xylene, phenol, polyethylene glycol, propionic acid, propyl lactate, propylene carbonate, propylene glycol, propylene glycol methyl ether, p-xylene, toluene, triethyl phosphate, triethylene glycol, xylene sulfonic acid, paraffin, mineral oil, trichloroethylene, perchloroethylene, ethyl acetate, amyl acetate, butyl acetate, propylene glycol methyl ether, diethylene glycol methyl ether, methanol, ethanol, isopropanol and higher molecular weight alcohols (e.g., amyl alcohol, tetrahydrofurfuryl alcohol, hexanol, octanol, ethylene glycol, propylene glycol, glycerol), N-methyl-2-pyrrolidone, and the like.

[0067] Biocides / microorganisms can cause the formulation to deteriorate. Therefore, antimicrobial agents are used to eliminate or reduce their effects. Such agents include, but are not limited to, propionic acid and its sodium salts, sorbic acid and its sodium or potassium salts, benzoic acid and its sodium salts, p-hydroxybenzoic acid sodium salts, methyl parahydroxybenzoate, and biocides such as sodium benzoate, 1,2-benzisothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isoxazolin-3-one, potassium sorbate, parahydroxybenzoates, or mixtures thereof.

[0068] Thickeners, gelling agents and anti-settling agents are generally divided into two categories, i.e. water-insoluble particles and water-soluble polymers. Clay and silicon dioxide (such as but not limited to montmorillonite (such as bentonite), magnesium aluminum silicate and attapulgite) can be used to produce suspension concentrate formulations. Water-soluble polysaccharides have been used for many years as thickening gelling agents. The most commonly used polysaccharide types are natural extracts of seeds and seaweed, synthetic derivatives of cellulose or mixtures thereof, such as but not limited to guar gum, locust bean gum, carrageenan, xanthan gum, alginate, methylcellulose, sodium carboxymethylcellulose (SCMC), hydroxyethyl cellulose (HEC) or mixtures thereof. Other types of anti-settling agents are based on modified starch, polyacrylate, polyvinyl alcohol and polyethylene oxide or mixtures.

[0069] Suitable colorants are selected from crystal violet, thalocyano chloride dye, aerosol green FFB dye, rhodamine, azo compounds, iron oxide, titanium oxide, ferric ferrocyanide, alizarin and phthalocyanine colorants.

[0070] The fast coating agent can be a conventionally available adhesive, such as polyester, polyamide, polycarbonate, polyurea and polyurethane, acrylate polymers and copolymers, styrene copolymers, butadiene copolymers, polysaccharides such as starch and cellulose derivatives, vinyl alcohol, vinyl acetate and vinyl pyrrolidone polymers and copolymers, polyethers, epoxy resins, phenolic resins and melamine resins, polyolefins, and their copolymers and mixtures are defined. The polymer is selected from acrylate polymers (e.g., poly(methacrylate), poly(ethyl methacrylate), poly(methyl methacrylate)), acrylate copolymers and styrene-acrylic acid copolymers, poly(styrene-to-maleic anhydride), cellulose polymers (e.g., ethyl cellulose, cellulose acetate, cellulose acetate butyrate), acetylated monoglycerides, acetylated diglycerides and acetylated triglycerides, poly(vinyl pyrrolidone), vinyl acetate polymers and copolymers, poly(ethylene glycol), styrene butadiene copolymers, poly(orthoesters), alkyd resins, and mixtures of two or more thereof. Biodegradable polymers can also be used in the present invention. As used herein, a polymer is biodegradable, even if it is insoluble in water, but will degrade after being placed in the application environment for several weeks. The biodegradable polymer is selected from biodegradable polyesters, starch, polylactic acid starch blends, polylactic acid, poly (lactic acid-glycolic acid) copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch ester aliphatic polyester blends, modified corn starch, polycaprolactone, poly (n-pentyl methacrylate), wood resins, polyanhydrides, polyvinyl alcohol, polyhydroxybutyrate valerate, biodegradable aliphatic polyesters, polyhydroxybutyrates, or mixtures thereof.

[0071] Biodegradable polymers can also be used in the present invention. As used herein, polymers are biodegradable, even if insoluble in water, but placed in an application environment and degraded over a period of several weeks. Biodegradable polymers are selected from starch, polylactic acid starch blends, polylactic acid, poly(lactic acid-glycolic acid) copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch ester aliphatic polyester blends, modified corn starch, polycaprolactone, poly(n-pentyl methacrylate), wood resins, polyanhydrides, polyvinyl alcohol, polyhydroxybutyrate valerate, biodegradable aliphatic polyesters and polyhydroxybutyrate or mixtures thereof.

[0072] The disintegrant is selected from, but not limited to, citric acid, succinic acid or sodium bicarbonate.

[0073] The oil additive is selected from oils of vegetable origin (such as rapeseed oil, olive oil or sunflower oil), emulsified vegetable oils or oils of animal origin (such as fish oil or tallow), C8-C 22 Alkyl esters of fatty acids (e.g. 12-C 18 Methyl derivatives of fatty acids, for example the methyl esters of lauric acid, palmitic acid and oleic acid (methyl laurate, methyl palmitate and methyl oleate, respectively).

[0074] The buffer used herein is selected from calcium hydroxyapatite, potassium dihydrogen phosphate, sodium hydroxide, carbonated apatite, calcium carbonate, sodium bicarbonate, tricalcium phosphate, calcium phosphate, carbonated calcium phosphate, amine monomers, lactate dehydrogenase and magnesium hydroxide.

[0075] The solvent used for the preparation of the present invention is selected from but not limited to water, water-soluble alcohol and dihydroxy alcohol ether. The water-soluble alcohol that can be used for the present invention is selected from lower alcohol or water-soluble macromolecular alcohol. The term "lower alcohol" used in this article means an alcohol with 1 to 4 carbon atoms, such as methanol, ethanol, n-propanol, isopropanol, n-butanol, tert-butanol, etc. There is no restriction on macromolecular alcohol, as long as it can be dissolved in water with a suitable amount range, such as polyethylene glycol, sorbitol, glucitol, etc. The suitable dihydroxy alcohol ether used in the present invention is selected from dihydroxy alcohol alkyl ether or dihydroxy alcohol aryl ether. Dihydroxy alcohol alkyl ether includes ethylene glycol methyl ether, diethylene glycol methyl ether, propylene glycol methyl ether, dipropylene glycol methyl ether, ethylene glycol ethyl ether, diethylene glycol ethyl ether, propylene glycol ethyl ether and dipropylene glycol ethyl ether, etc. Dihydroxy alcohol aryl ether includes ethylene glycol phenyl ether, diethylene glycol phenyl ether, propylene glycol phenyl ether, dipropylene glycol phenyl ether, etc. Any solvent described above can be used alone or in combination.

[0076] However, those skilled in the art will appreciate that other agrochemically acceptable excipients may be used without departing from the scope of the present invention.The agrochemically acceptable excipient may range from 0.1% to 99% of the total weight of the composition.

[0077] The application rate of the composition according to the invention will depend on various factors, such as the object of treatment (e.g., plant, soil or seed), the type of treatment (e.g., spraying, dusting or seed dressing), the purpose of treatment (e.g., preventive or curative disease control), the type of fungus to be controlled in the case of disease control or the time of application. Such application rates of the combination of the invention can be easily deduced by an agricultural technician.

[0078] The combination of the present invention is formulated in a manner suitable for a specific application. The formulation is selected from capsule suspensions (CS), emulsifiable concentrates (EC), water-in-oil emulsions (EO), oil-in-water emulsions (EW), Jambo balls or bags (bags in water-soluble bags), microemulsions (ME), oil dispersants (OD), oil-miscible flowable concentrates (oil-miscible suspensions (OF)), oil-miscible liquids (OL), suspension concentrates (SC), suspoemulsions (SE), soluble concentrates (SL), wettable granules / water-dispersible granules (WG / WDG), water-soluble granules (SG), water-soluble powders (SP), wettable powders (WP), mixed formulations of CS and SC (ZC), mixed formulations of CS and SE (ZE), mixed formulations of CS and EW (ZW), granules (GR) / soil-applied granules (SAG), controlled-release granules (CR).

[0079] More particularly, the formulation is selected from oil dispersions (OD), wettable granules (WG), emulsifiable concentrates (EC) and suspension concentrates (SC).

[0080] The inactive excipients used in the various formulations are as follows:

[0081] A. List of inactive excipients used in oil dispersion (OD) formulations:

[0082] The wetting agent used in the oil dispersant (OD) is selected from ethylene oxide / propylene oxide block copolymers, polyaryl phenyl ether phosphates, ethoxylated fatty alcohols, sodium dioctyl sulfosuccinate, sodium lauryl sulphate, sodium dodecyl benzenesulfonate, alkyldiphenyl sulfonate, sodium isopropyl naphthalene sulfonate, alkylnaphthalene sulfonate or mixtures thereof.

[0083] The wetting, diffusing and penetrating agent for oil dispersant (OD) is selected from silicone surfactant trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methylpolysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethylsiloxane copolymer, heptamethyl trisiloxane, polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, which may or may not be in modified form, in liquid or powder form or a mixture thereof.

[0084] The emulsifier used for the oil dispersant (OD) is selected from castor oil ethoxylate, alcohol ethoxylate, fatty acid ethoxylate, sorbitan ester ethoxylate, sulphosuccinate, calcium salt of dodecylbenzene sulfonate, alkylammonium salt of alkylbenzene sulfonate, alkyl sulfosuccinate, ethylene oxide-propylene oxide block copolymer, ethoxylated alkylamine, ethoxylated alkylphenol, polyoxyethylene sorbitan monolaurate or mixtures thereof.

[0085] The dispersant used for the oil dispersant (OD) is selected from the group consisting of alkyl sulfonates, alkylbenzene sulfonates, alkylaryl sulfonates, alkylphenol alkoxylates, tristyrylphenol ethoxylates, natural or synthetic fatty ethoxylated alcohols, natural or synthetic fatty acid alkoxylates, natural or synthetic fatty alcohol alkoxylates, alkoxylated alcohols, n-butyl alcohol polyethylene glycol ethers, block copolymers, ethylene oxide-propylene oxide block copolymers, ethylene oxide-butylene oxide block copolymers, fatty acid-polyalkylene glycol condensates, polyamine-fatty acid condensates, polyester condensates, salts of polyolefin condensates, sodium lignin sulfonate, sodium polycarboxylates, EO / PO-based copolymers, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymers, propylene oxide-ethylene oxide copolymers, polyethylene glycol 2,4,6-tristyrylphenyl ether, ether), tristyrylphenol-polyglycolether-phosphate, tristyrylphenol with 16 moles of EO, tristyrylphenol-polyglycolether-phosphate, oleyl-polyglycolether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9 to 10 moles of ethylene oxide, or a mixture thereof.

[0086] The stabilizer for the oil dispersant (OD) is selected from hectorite clay, aluminum magnesium silicate, bentonite clay, silica, attapulgite clay or mixtures thereof.

[0087] The defoamer for oil dispersant (OD) is selected from silicone oil, organosilicon compound, C 10 ~C 20 Saturated fatty acid compounds or C8~C 10 Fatty alcohol compounds, silicone antifoaming emulsions, dimethylsiloxanes, polydimethylsiloxanes, vegetable oil-based antifoaming agents, animal fat-based fatty acids, polyoxyalkylene-modified polydimethylsiloxanes, or mixtures thereof.

[0088] The antifreeze agent used in the oil dispersion (OD) is selected from ethylene glycol, propylene glycol, glycerine or urea, glycol, monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol, glycerine, urea, magnesium sulfate heptahydrate, sodium chloride or a mixture thereof.

[0089] The preservative used in the oil dispersant (OD) is selected from 1,2-benzisothiazolin-3(2H)-one, sodium salt, sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenylphenol, 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one or a mixture thereof.

[0090] As the solvent of the present preparation, the solvent used for the oil dispersant (OD) is selected from but not limited to vegetable oil (plant, seed or tree) or its alkylate or ethoxylate or ester. The alkylated vegetable oil can be methylated vegetable oil or ethylated vegetable oil. Vegetable oil includes olive oil, kapok oil, castor oil, papaya oil, camellia oil, sesame oil, corn oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, rapeseed mustard oil, linseed oil, tung oil, sunflower oil, safflower oil, coconut oil. The alkyl ester of vegetable oil is methyl, ethyl, propyl or butyl ester of vegetable oil, methylated seed oil, polyoxyalkylene-modified polydimethylsiloxane alkylphenol ethoxylate, rapeseed oil methyl ester, rapeseed oil ethyl ester, rapeseed oil propyl ester, rapeseed oil butyl ester, soybean oil methyl ester, soybean oil ethyl ester, soybean oil propyl ester, soybean oil butyl ester, castor oil methyl ester, castor oil ethyl ester, castor oil propyl ester, castor oil butyl ester, cottonseed oil methyl ester, cottonseed oil ethyl ester, cottonseed oil butyl ester, cottonseed oil propyl ester, tall oil fatty acid ester-tallow methyl ester, tallow ethyl ester, tallow propyl ester, biodiesel, mineral oil, aromatic solvent, isoparaffin, alkaline solvent, fatty acid amide, C1-C3 amine, alkylamine or C6-C 18 Alkanolamines of carboxylic acids, fatty acids, alkyl esters of fatty acids, methyl and ethyl oleate, methyl and ethyl soyaate, alkylbenzenes and alkylnaphthalenes, polyalkylene glycol ethers, fatty acid diesters, fatty alkylamides and diamides, dialkylene carbonates, ketones and alcohols. The above oil-based carriers / diluents may be used alone or as a mixture of two or more if desired.

[0091] The cosolvent for the oil dispersant (OD) is selected from cyclohexanone, acetophenone, NMP, dimethyl sulfoxide, benzyl alcohol, butanol, N-octanol, N-propanol, 2-ethylhexanol, tetrahydrofurfuryl alcohol, isophorone, fatty acid dimethylformamide, 2-hexylethyl lactate, propylene carbonate or a mixture thereof.

[0092] More specifically, the present invention also relates to a method of making an oil dispersant formulation, the following steps being described.

[0093] It is to be understood that the steps described below apply to all formulations made.

[0094] Step 1: Ensure the cleanliness of all equipment in the plant and obtain approval from the quality control (QC) department before starting the method.

[0095] Step 2: Ensure electrical connections and standardize the weighing balance.

[0096] Manufacturing method for oil dispersant (OD) formulation:

[0097] Part A - Preparation of Liquid Premix

[0098] Step 1- Charge the vegetable oil or solvent or both into a container with an anchor stirrer.

[0099] Step 2-Add the emulsifier and dispersant with stirring until all ingredients are completely dissolved.

[0100] Part B - Slurry Preparation

[0101] Step 1 - Charge the liquid premix into a second container equipped with a cooling and heating device with a high shear mixer.

[0102] Step 2 - Add the active ingredient and homogenize thoroughly. The mixture is pre-milled and the particle size distribution is achieved according to the technical specifications by final milling with a bead mill.

[0103] Part C - Preparation of Thickener Gel

[0104] Step 1 - Charge the vegetable / plant / seed oil or solvent into a container equipped with a high shear mixer.

[0105] Step 2 - Gradually add thickener, mixing and maintaining high shear throughout. Continue stirring until thoroughly combined.

[0106] Step 3 - Add the thickener activator under stirring. Also, allow the gel to swell while maintaining mixing.

[0107] Part D - Preparation of Final Formulation

[0108] Step 1 - Add the thickener gel and disperse the mixture by using a high shear mixer.

[0109] Step 2 - Finally the recommended wetting and spreading agent or adjuvant (silicone or non-silicone based) is added to the formulation and dispersed by using a high shear mixer.

[0110] Step 3 - Check the finished formulation against technical specifications.

[0111] Step 4- After approval, the material is packed in the required packing size.

[0112] B. List of inactive excipients used in (wettable granules) WG formulations:

[0113] The dispersant used for wettable granules (WG) is selected from sodium polycarboxylate, sodium polyacrylate, naphthalene sulfonic acid, sodium salt condensates with formaldehyde, polyalcoxylated alkylphenol, naphthalene sulfonic acid formaldehyde condensates, methylnaphthalene-formaldehyde condensate sodium salt, naphthalene condensate, lignin sulfonate, calcium lignin sulfonate, lignin sulfonate sodium salt, alkyl naphthalene sulfonate (sodium salt) or mixtures thereof. The preferred dispersant is alkyl naphthalene sulfonate. It provides excellent wettability, dispersibility, hydrophilicity and low to medium foaming properties. It provides acid and alkali stability, hard water resistance and high temperature stability.

[0114] The wetting agent for wettable granules (WG) is selected from sodium N-methyl-N-oleyl taurate, alkylated naphthalene sulfonate, sodium salt, a mixture of isomers of dibutylnaphthalene sulfonate sodium salt, sodium diisopropylnaphthalene sulfonate, sodium lauryl sulfate, dioctyl sulfate, alkyl naphthalene sulfonate, phosphate esters, sulphosuccinate and nonionic tridecyl alcohol ethoxylates, alkyl or alkylaryl sulfonates, alkylbenzene sulfonates, α-olefin sulfonates and alkylnaphthalene sulfonates, ethoxylated or non-ethoxylated alkyl or alkylaryl carboxylates, alkyl or alkylaryl phosphates, alkyl polysaccharides, di or mono alkyl sulfosuccinate derivatives. derivative), α-olefin sulfonates, alkyl naphthalene sulfonates, dialkyl sulfosuccinates, butyl naphthalene sulfonates, dibutyl naphthalene sulfonates, isopropyl naphthalene sulfonates and diisopropyl naphthalene sulfonates, C 12 Alkylbenzene sulfonate or C 10 -C 16Alkylbenzene sulfonate, silicone surfactant, trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methylpolysiloxane, polyoxyalkylene methylpolysiloxane, polyether polymethylsiloxane copolymer, heptamethyltrisiloxane, polyoxyalkylene-modified heptamethyltrisiloxane, polyether-modified polysiloxane, which may or may not be in modified form, and may be in liquid or powder form or a mixture thereof.

[0115] The defoamer used for wettable granules (WG) is polydimethylsiloxane.

[0116] The carrier for wettable granules (WG) is selected from china clay, silica, anhydrous lactose, ammonium sulfate, anhydrous sodium sulfate, corn starch, urea, EDTA, urea-formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, Fuller's earth, attapulgite clay, bole, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulfate, sodium chloride, gypsum, calcium sulfate, pyrophyllite, silicates and silica gel; ammonium sulfate, ammonium phosphate, ammonium nitrate and urea; natural products of plant origin, grain meal and flour, bark meal meal), wood flour, nut shell flour and cellulose flour; and synthetic polymeric materials, ground or pulverized plastics and resins, bentonites, zeolites, titanium dioxide, iron oxides and hydroxides, aluminium oxides and hydroxides, or organic materials, bagasse, charcoal, or synthetic organic polymers, or mixtures thereof.

[0117] The humectant used in wettable granules (WG) is selected from humic acid, glycerol, lactose, anhydrous sodium sulfate or a mixture thereof.

[0118] More specifically, the present invention also relates to a process for preparing a wettable granule formulation, describing the following steps:

[0119] Preparation method of water dispersible granules WG / WDG:

[0120] Step 1: The exact weight of active ingredient under consideration along with required amount of binder and surfactant is added into a blender and mixed to achieve complete homogenization.

[0121] Step 2: Grind the homogeneous mixture to achieve desired wet sieving and then blend to obtain homogeneity.

[0122] Step 3: The above homogenized material is passed through an extruder to be pelletized.

[0123] Step 4: Pass the granules through a fluid bed dryer to remove excess water.

[0124] Step 5: Transfer the pellet to a vibrating transposer.

[0125] Step 6: Collect the final material from the vibrating shifter into a bucket.

[0126] Step 7: Send samples for quality control for approval.

[0127] Step 8: After getting approval from quality control, the material is transferred into drums of different sizes.

[0128] C. List of inactive excipients used in emulsifiable concentrate (EC) formulations:

[0129] The solvent for the emulsifiable concentrate (EC) is selected from aromatic hydrocarbons, C-9, toluene, o-xylene, m-xylene, p-xylene, dodecane, n-decane, n-hexane, benzene, ethylbenzene, isopropylbenzene, tert-butylbenzene, naphthalene, monoalkyl or polyalkyl substituted naphthalene, depleted heavy aromatic naphthalene (aromatic 200, 100, 150), n-butanol, N-methyl-2-pyrrolidine, methanol, ethanol, n-propanol, isopropyl alcohol, n-butanol, tert-butanol, paraffin, cyclohexanone, isophorone, ester solvents, methyl oleate, C6-C 16 Dimethylamide and morpholineamide derivatives of fatty acids, monoolefin carbonate, ethylene carbonate, propylene carbonate, butylene carbonate, dimethyl sulfoxide (DMSO), 2-ethylhexanol, n-butanol, n-alkylpyrrolidone, fatty acid dimethyl ester, fatty acid ester, dibasic ester, aromatic hydrocarbons, aliphatic hydrocarbons, one or more dimethylamides, C8-dimethylamide, C 10 -Dimethylamine, C 12 -dimethylamide, ethylene glycol, propylene glycol, polyalkylene glycol, methyl pyrrolidone (NMP), N,N-decylamide, dimethylformamide (DMF), dimethyl isosorbide (DMI), isophorone, acetophenone, 1,3-dimethyl-2-imidazolidinone, lactic acid esters, dimethyl carbonate and diethyl carbonate, alcohols, methanol, ethanol, isopropanol, n-propanol, n-butanol, isobutanol and tert-butanol, methyl L-lactate, 2-ethylhexyl L-lactate, ethyl L-lactate, n-butyl L-lactate, octylphenyl ethoxylate or mixtures thereof.

[0130] The emulsifier used for the emulsifiable concentrate (EC) is selected from: dodecylbenzene sulfonate, calcium salt or amine salt, other C 11 -C 16Emulsifiers of alkylbenzene sulfonates, alkyl ether sulfates, alkylphenol ether phosphates and ester phosphates; nonionic surfactants, alkoxylated alcohols and alkylphenols, ethoxylated fatty acids, ethoxylated vegetable oils, ethoxylated castor oils, fatty acid esters, sorbitol and its ethoxylated derivatives, ethoxylated amines, condensates of glycerol; catanionic emulsifiers, cationic amines, alkyl sulfonates or ether sulfonates or ether phosphates, alkoxylated alcohols, alkoxylated alkylphenols, ethoxylated fatty acids, ethoxylated vegetable oils, ethoxylated tristyrylphenols, fatty acid esters of sorbitol and its ethoxylated derivatives; condensates of ethoxylated amines and glycerol; C 11 -C 16 Sulfonated alkylbenzenes and salts thereof within the scope of the present invention; alkyl ether sulfates; alkyl ether phosphates; alkylphenol ether phosphates; or combinations thereof; salts of phosphate esters of ethoxylated tristyrylphenol; salts of sulfated ethers of ethoxylated tristyrylphenol; or catanionic systems in which cationic amines are present in combination with alkyl sulfonates, alkyl ether sulfonates, ether sulfates or ether phosphates (alkyl ether phosphates), nonylphenol polyethoxyethanol, castor oil polyglycol ether, polyadducts of ethylene oxide and polypropylene, tributylphenoxypolyethoxyethanol, octylphenoxypolyethoxyethanol, calcium alkylbenzene sulfonate sodium salt, polyarylphenyl anionic ether sulfate ammonium salt or mixtures thereof.

[0131] The adhesive, surface tension reducer and binder used in the emulsifiable concentrate (EC) is polyvinyl pyrrolidone.

[0132] The dispersants, adhesives, penetrants and surface tension reducers used in emulsifiable concentrates (EC) are alkyl polyglycol ethers.

[0133] The superwetting diffusing penetrant used in the emulsifiable concentrate (EC) is polyoxyalkylene-modified heptamethyltrisiloxane.

[0134] More specifically, the present invention also relates to a method for preparing an emulsifiable concentrate formulation, describing the following steps:

[0135] Preparation method of emulsifiable concentrate EC:

[0136] Step 1: Fill the solvent into a container, slowly add the required amount of active ingredient and mix well until it is completely dissolved.

[0137] Step 2: Slowly add the emulsifier to the premix and homogenize to obtain a uniform solution.

[0138] Step 3: Add the wetting diffusion penetrant and mix thoroughly to achieve a homogeneous transparent solution which is then sent for quality control for quality inspection.

[0139] D. List of inactive excipients used in suspension concentrate (SC) formulations:

[0140] The wetting agent for suspension concentrate (SC) is selected from ethylene oxide / propylene oxide block copolymers, polyaryl phenyl ether phosphates, polyalkoxylated butyl ethers, ethoxylated fatty alcohols, sodium dioctyl sulfosuccinate, sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, alkyl dibenzene sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonates, silicone surfactants, wetting diffusion penetrants trisiloxane ethoxylates, polydimethylsiloxanes, polyoxyethylene methylpolysiloxanes, polyoxyalkylene methylpolysiloxanes, polyether polymethylsiloxane copolymers, heptamethyltrisiloxane, polyoxyalkylene-modified heptamethyltrisiloxane, polyether-modified polysiloxanes, polyoxyalkylene-modified trisiloxanes, polyoxyalkylene-modified polydimethylsiloxanes, trisiloxane ethoxylates, polyoxyethylene methylpolysiloxanes, polyether polymethylsiloxane copolymers, polyether-modified polysiloxanes, which may or may not be in modified form and may be in liquid or powder form or mixtures thereof.

[0141] The dispersant used in the suspension concentrate (SC) is selected from sodium naphthalene sulfonate formaldehyde condensate, alkylated naphthalene sulfonate (sodium salt), sodium salt of naphthalene sulfonate condensate, sodium lignin sulfonate, sodium polycarboxylate, EO / PO based copolymer, phenol sulfonate, sodium methyl oleyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide copolymer, polyethylene glycol 2,4,6-tristyryl phenyl ether, tristyrylphenol-polyethylene glycol ether-phosphate, tristyrylphenol with 16 moles of EO, tristyrylphenol-polyethylene glycol ether-phosphate, oleyl polyethylene glycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyethylene glycol ether with 9 to 10 moles of ethylene oxide or a mixture thereof.

[0142] The suspending agent used in the suspension concentrate (SC) is selected from magnesium aluminum silicate, bentonite clay, silica, attapulgite clay or mixtures thereof.

[0143] The defoamer for suspension concentrate (SC) is selected from silicone oil, organosilicon compound, C 10 ~C 20 Saturated fatty acid compounds or C8~C 10 Fatty alcohol compounds, silicone antifoaming emulsions, dimethylsiloxanes, polydimethylsiloxanes, vegetable oil-based antifoaming agents, animal fat-based fatty acids, polyoxyalkylene-modified polydimethylsiloxanes, or mixtures thereof.

[0144] The antifreeze agent used for suspension concentrate (SC) is selected from ethylene glycol, propylene glycol, glycerine or urea, glycol, monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol, glycerine, urea, magnesium sulfate heptahydrate, sodium chloride or a mixture thereof.

[0145] The preservative used in the suspension concentrate (SC) is selected from 1,2-benzisothiazolin-3(2H)-one (sodium salt), sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenylphenol, 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one or a mixture thereof.

[0146] The thickener used for the suspension concentrate (SC) is selected from xanthan gum, PVK, carboxymethyl cellulose, polyvinyl alcohol, gelatin, sodium carboxymethyl cellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch, gum arabic or a mixture thereof.

[0147] The humectant used in the suspension concentrate (SC) is selected from urea, humic acid, glycerol, lactose or a mixture thereof.

[0148] More specifically, the present invention also relates to a process for preparing a suspension concentrate formulation, the following steps being described.

[0149] Manufacturing method for suspension concentrate (SC) formulations:

[0150] Step 1 - Gel Preparation: Charge required amount of water in a container equipped with high shear mixer while starting stirring. Add required amount of preservative and mix to form a homogenous mixture. Add required amount of thickener and mix vigorously to achieve wetting.

[0151] Step 2 - Charge the required amount of water in a container equipped with a bulk agitator and a high shear homogenizer; start stirring. Also, add the required amount of antifreeze and mix to achieve homogeneity. Also, add the defoamer while ensuring that it is well dispersed. Add the wetting dispersant and mix to achieve homogeneity while ensuring that the dispersant is fully dispersed.

[0152] Step 3 - Add the active ingredient and continue stirring the vessel contents until all components are dissolved. Grind the premix through a colloid mill and then a dyno mill to meet the specified particle size.

[0153] Step 4 - Add the rest of the defoamer to this SC mill base in a container equipped with a large volume stirrer and mix to achieve homogeneity.Add the required amount of 2% aqueous pre-gel and suspending agent and continue stirring until the formulation is homogenized and the target viscosity is reached.

[0154] Step 5 - Submit the final product for quality control approval.

[0155] Step 6- After approval, the material is packed in the required packing size.

[0156] Example

[0157] The present invention has been described with reference to specific embodiments, which are merely illustrative and are not intended to limit the scope of the invention as defined in this entire specification.

[0158] Biological Examples:

[0159] The synergistic insecticide action of the mixture of the present invention can be demonstrated by the following experiments. A synergistic effect exists as long as the action of the combination (premix) or canned mixture of the active ingredients is greater than the sum of the actions of each ingredient alone. Thus, a synergistically effective amount or effective amount of a synergistic composition or combination is an amount that exhibits an insecticide activity greater than the sum of the insecticide activities of the individual ingredients.

[0160] In the agricultural field, it is generally understood that the term "synergistic effect" is defined as Colby SR in an article entitled "Calculation of the synergistic and antagonistic responses of herbicide combinations" (published in the journal Weeds, 1967, 15, pp. 20-22), which is incorporated herein by reference in its entirety. The expected effect for a given combination of two or three active ingredients can be calculated as follows:

[0161] Colby's formula for calculating the synergistic effect between two active ingredients,

[0162]

[0163] Where E = expected / calculated control of the mixture or combination of Compound A and Compound B at a defined dose, X = observed control of Compound A, and Y = observed control of Compound B.

[0164] Colby's formula for calculating the synergistic effect between three active ingredients,

[0165]

[0166] Where E = expected / calculated control of a mixture or combination of Compound A, Compound B and Compound C at a defined dose, X = observed control of Compound A, Y = observed control of Compound B, and Z = observed control of Compound C.

[0167]

[0168] If the Colby ratio is >1 it means that a synergistic effect is observed, <1 means that an antagonistic effect is observed and =1 means a simple additive effect.

[0169] A higher ratio means a stronger synergistic effect, and a lower ratio means a weaker synergistic effect.

[0170] The aim of this study was to investigate the synergistic effects and benefits of a composition comprising fluoxetine, at least one insecticide and at least one plant health additive and the composition was analyzed.

[0171] Example 1: Biological efficacy against pepper thrips and fruit borers and impact on yield

[0172] Crop: Pepper (Capsicum annuum L.)

[0173] Location: Bochasan, Gujarat

[0174] Number of times processed: 19

[0175] Plot size: 44sq.m.

[0176] Crop stage: 80 days after transplanting

[0177] Method of application: Foliar spraying with a battery-powered backpack sprayer

[0178] Water volume: 500 liters / hectare

[0179] Observation method:

[0180] Thrips (mixed infestation of Thrips parvispinusis and Scirtothrips dorsalis): The number of live thrips was counted on black paper by shaking the branches. Observations were recorded for 3 branches per plant and 10 plants per plot at 7 and 14 DAA (days after application). Thrips control (%) was calculated as observed control and synergistic effects were calculated using the colby formula.

[0181]

[0182] Fruit borer (Helicoverpa armigera) larvae control (%): The number of live larvae was counted per plant. Observations were recorded on 10 plants per plot at day 7 after application.

[0183]

[0184] The fruit borer larvae control (%) data were used to examine synergistic effects by applying Colby's formula given above.

[0185] Healthy fruit count: The number of healthy fruits per plant was counted. Observations for 10 plants per plot were recorded and the increase (%) in healthy fruits relative to UTC (untreated check) was calculated.

[0186]

[0187] T1: Composition of fluoxetine 6% + avermectin 1.8% + gibberellin 0.4% EC

[0188]

[0189]

[0190] T1: Manufacturing method for 100kg batch of fluoxetine 6% + avermectin 1.8% + gibberellin 0.4% EC

[0191] Step 1: Add 15.0 kg of N,N-decylamide and 56.80 kg of aromatic solvent into another slowly stirred container. In addition, add 6.0 kg of fluoxazolidinone (active ingredient), 1.8 kg of avermectin and 0.4 kg of gibberellin and mix properly for 30 to 45 minutes.

[0192] Step 2: Add 8.0 kg of calcium alkylbenzene sulfonate sodium salt and 7.0 kg of polyarylphenyl anionic ether sulfate ammonium salt and mix properly for 30 to 45 minutes.

[0193] Step 3: 5.0 kg of polyoxyalkylene-modified heptamethyltrisiloxane was added to the formulation, which was then sent for quality control for quality inspection.

[0194] T2: Composition of fluazifop 3% + tolfenpyrad 12% + gibberellin 0.2% SC

[0195]

[0196] ai (active ingredient) based on 100% purity

[0197]

[0198]

[0199] T2: Manufacturing method for 100kg batch of fluazifop 3% + tolfenpyrad 12% + gibberellin 0.2% SC Law

[0200] Step 1 - Gum solution: Xanthan gum (2.0 kg) and 1,2-benzisothiazolin-3-one (2.0 kg) were added to 96.0 kg of water and homogenized. The above mixture was prepared 12 to 18 hours before use.

[0201] Step 2 - Charge DM water (60.7 kg) and 1,2-propylene glycol (5 kg) into a designated container and mix thoroughly.

[0202] Step 3 - Sodium polycarboxylate salt (1.0 kg), acrylic acid graft copolymer (4.5 kg) and bentonite clay (0.5 kg) were added to a container with water and the contents were homogenized by using a high shear homogenizer for 45 to 60 minutes.

[0203] Step 4 - Slowly add fluazifop (3.0 kg), tolfenpyrad (12.0 kg) and gibberellin (0.2 kg) to the premix and homogenize to achieve a homogenous slurry ready for grinding.

[0204] Step 5 - Half the amount of dimethicone (0.15 kg) was added before grinding and the material was then ground in a Dyno mill until the desired particle size was achieved.

[0205] Step 6 - After the grinding process was completed and before sampling for in-process analysis, the remainder of the polydimethylsiloxane (0.15 kg) antifoam agent was added.

[0206] Step 7 - 7.5 kg of 2% xanthan gum solution and 5.0 kg of polyoxyalkylene-modified heptamethyltrisiloxane (superwetting diffusing penetrant) were added to the formulation and homogenized for 30 minutes.

[0207] Step 8- The final formulation is sent for quality control for quality check.

[0208] Table 1: Processing details

[0209]

[0210]

[0211] GA - Gibberellins, SC - Suspension Concentrate, EC - Emulsifiable Concentrate, WSG - Water Soluble Granules, SL - Soluble Liquid, DC - Dispersible Concentrate. T1 to T5 are innovative compositions of the present invention, T6 to T10 are known compositions (prior art), T11 is a farm tank mix, T12 to T16 are market products, and T17 and T18 are field trial formulations developed in-house.

[0212] Table 2a: Thrips control in pepper crops

[0213]

[0214] All the innovative compositions of the present invention (T1 to T5) provided synergistic and residual control of thrips up to 14 days, while all the known compositions (T6 to T11) did not provide residual control as shown by the compositions of the present invention, and it was found that the control of thrips at 14 DAA of the other compositions except the compositions of the present invention was less than 55.8%.

[0215] Table 2b: Fruit borer larvae control and pepper fruit yield

[0216]

[0217] All of the inventive compositions (T1 to T5) provided excellent control of fruit borer larvae (greater than 83%) and also resulted in a higher number of marketable fruits per plant (increase of greater than 108 relative to UTC).

[0218] Conclusion: Among the various compositions shown in Table 1, treatment numbers T1 to T5 were considered to be the innovative compositions of the present invention showing excellent synergistic effects and effectiveness against pepper thrips and fruit borer larvae on pepper crops. The thrips control observed at 7DAA (days after application) for T1 to T5 exceeded 96.8%. In particular, T2 showed the highest thrips control at 7DAA (99.2%), followed by T1 (98.4%) and T3 (98.2%), and was found to exceed 77.4% at 14DAA. In particular, T1 showed the highest thrips control at 14DAA (84.6%), followed by T2 (81.2%) and (78.6%). In addition, the colby ratio was found to be greater than 1, which means a stronger synergistic effect.

[0219] Furthermore, the fruit borer larvae control of T1 to T5 was shown to be more than 83.6%. In particular, the fruit borer larvae control of T2 was 95.4%, followed by 93.8%, and T1 and T4 were 85.2%. In addition to this, the number of healthy fruits per plant was found to be more than 42.5. In particular, T2 showed the highest number of healthy fruits per plant (48.5), followed by T1 (46.7) and T3 (45.3). In addition, the increase in fruits relative to UTC (untreated control) was found to be more than 108.3%. In particular, when compared with known products, farm tank mixes, market products and field trial formulations developed in-house, as an excellent result, the increase in fruits of T2 relative to UTC (untreated control) was 137.7%, followed by T1 (128.9%) and T3 (122.1%).

[0220] Example 2: Red spider mite, shoot and fruit borer control and yield in eggplant Crop: Eggplant

[0221] Location: Durg, Chhattishgarh

[0222] Number of times processed: 19

[0223] Plot size: 50sq.m.

[0224] Crop age: 75 days after transplanting

[0225] Method of application: Foliar spraying with a battery-powered backpack sprayer

[0226] Water volume: 510 liters / hectare

[0227] Observation method:

[0228] Red spider mite (Tetranychus urticae) control (%): The number of motile stages of mites per unit area was counted using a 10x microscope. Observations were recorded for 5 sites per plant and 10 plants per plot. Red spider mite control (%) was calculated and colby's formula was applied.

[0229]

[0230] Shoot and Fruit Borer (Leucinoides orbonalis) Damage (%): Larvae of stalk and fruit borer cause damage to both twigs and fruits of brinjal crops. The number of healthy and infested fruits per plant was counted. Observations were recorded for 10 randomly selected plants per plot.

[0231]

[0232] Fruit counts: The number of healthy marketable fruits of 5 plants per plot was counted and the increase in healthy fruits relative to UTC was calculated.

[0233] Table 3: Processing details

[0234]

[0235]

[0236] WP - wettable powder. T1 to T5 are innovative compositions of the present invention, T6 to T10 are known compositions, T11 is a farm tank mix, and T12 to T18 are market products.

[0237] Table 4a: Control of Red Spider Mites on Eggplant

[0238]

[0239] All the inventive compositions (T1 to T5) provided synergistic control of red spider mites infesting eggplant crops and also showed higher efficacy.

[0240] Table 4b: Efficacy and yield of eggplant crops against twig and fruit borer damage

[0241]

[0242]

[0243] All of the inventive compositions (T1 to T5) provided excellent protection against twig and fruit borers and also resulted in a higher number of marketable fruits per plant.

[0244] Conclusion: Among the various compositions shown in Table 3, T1 to T5 are the innovative compositions of the present invention showing excellent synergistic effect and effectiveness against red spider mites, branch and fruit borers in eggplant crops. More than 93.2% control of red spider mites was observed. In particular, T3 showed 98.4% when compared with other known products and market products, followed by T2 (97.2%) and T1 (96.6%), which showed excellent synergistic effect. In addition, when compared with known products, farm tank mixes and market products, the Colby ratio was found to be greater than 1, showing an effective synergistic effect.

[0245] In addition, T1 to T5 have been shown to increase the number of healthy fruits per plant to more than 30.2. In particular, T5 showed a number of healthy fruits per plant of 32.7, followed by T4 (31.9) and T1 (31.5), which have been shown to be superior to known products, farm storage tank mixtures and market products. In addition to this, it was observed that the fruit damage was less than 1.83%, while the known products, farm storage tank mixtures and market products showed fruit damage of 2.24% to 13.68%. In addition, T1 to T5 were shown to increase the number of healthy fruits relative to UTC (untreated control) by more than 79.8%. In particular, when compared with known products, farm storage tank mixtures and market products, T5 showed an increase of 94.6% in healthy fruits relative to UTC (untreated control), followed by T4 (89.9%) and T1 (87.5%).

[0246] Example 3: Pod borer larvae control and yield of pigeon pea (red gram)

[0247] Crop: Pigeon peas

[0248] Location: Dabhoi, Gujarat

[0249] Processing: 19

[0250] Crop age: 112 days after sowing

[0251] Spray volume: 500 liters / hectare

[0252] Method of application: Foliar spraying using a battery-operated backpack sprayer equipped with a hollow cone nozzle.

[0253] Observation method:

[0254] Bean Pod Borer (Helicoverpa armigera) Larvae Control (%): The number of live larvae was counted per plant. Observations were recorded on 10 plants per plot at day 7 after application.

[0255]

[0256] Pod Count: Count the number of healthy pigeon pea pods on each plant. Record observations for 10 plants per plot.

[0257] T1: Composition of fluoxetine 4% + emamectin benzoate 1.8% + fulvic acid 1.0% SC

[0258]

[0259]

[0260] T1: Manufacturing method of fluoxetine 4% + emamectin benzoate 1.8% + fulvic acid 1.0% SC for 100kg batch

[0261] Step 1 - Gum solution: Xanthan gum (2.0 kg) and 1,2-benzisothiazolin-3-one (2.0 kg) were added to 96.0 kg of water and homogenized. The above mixture was prepared 12 to 18 hours before use.

[0262] Step 2 - Charge DM water (66.5 kg) and 1,2-propylene glycol (5 kg) into a designated container and mix thoroughly.

[0263] Step 3 - Sodium polycarboxylate (1.5 kg), tristyrylphenol ethoxylate phosphate (4.5 kg) and aluminum magnesium silicate (0.5 kg) were added to a container with water and the contents were homogenized by using a high shear homogenizer for 45 to 60 minutes.

[0264] Step 4 - Add fluoxetine (4 kg), emamectin benzoate (1.8 kg) and fulvic acid (1.0 kg) slowly to the premix and homogenize to achieve a homogenous slurry ready for milling.

[0265] Step 5 - Half the amount of dimethicone (0.15 kg) was added before grinding and the material was then ground in a Dyno mill until the desired particle size was achieved.

[0266] Step 6 - After the grinding process was completed and before sampling for in-process analysis, the remainder of the polydimethylsiloxane (0.15 kg) antifoam agent was added.

[0267] Step 7 - 10.0 kg of 2% xanthan gum solution and 5.0 kg of polyoxyalkylene-modified heptamethyltrisiloxane were added to the formulation and homogenized for 30 minutes.

[0268] Step 8- The final formulation is sent for quality control for quality check.

[0269] Table 5: Processing details

[0270]

[0271]

[0272] T1 to T5 are innovative compositions of the present invention, T6 to T10 are known compositions, T11 is a farm tank mix, and T12 to T18 are market products.

[0273] Table 6: Pod borer larvae control and pod yield in pigeon pea

[0274]

[0275] All of the inventive compositions (T1 to T5) provided synergistic control of pod borer larvae and provided excellent protection of pods (less than 0.51% pod damage) and also resulted in a higher number of healthy pods per plant (greater than 106%) compared to all known compositions, farm tank mixes and market products.

[0276] Conclusion: Among the various compositions shown in Table 5, treatment numbers T1 to T5 were considered to be the innovative compositions of the present invention showing excellent synergistic effect and effectiveness in controlling pod borer larvae in pigeon pea. In addition, control of pod borer larvae was shown to be over 98.2%. In particular, T5 showed 100% compared to the farm tank mix and the market product, followed by T4 (99.4%) and T3 (99.2%), demonstrating excellent control.

[0277] In addition to this, T1 to T5 showed a smaller number of pod damage, less than 0.51%, compared to the known products, farm tank mixes, and market products, which showed pod damage ranging from 0.57% to 8.77%. In addition, T1 to T5 showed a number of healthy pods per plant of more than 122.5. In particular, T5 showed a number of healthy pods per plant of 137.7, followed by T4 (133.5) and T3 (130.2), when compared to the known products, farm tank mixes, and market products. Last but not least, T1 to T5 showed an increase of more than 106.6% in healthy pods relative to UTC (untreated control). In particular, T5 showed an increase of 132.2% in healthy pods relative to UTC (untreated control), followed by T4 (125.1%) and T3 (119.6%), when compared to the known products, farm tank mixes, and market products.

[0278] Example 4: Whitefly Control on Cucurbits

[0279] Crop: Gourd

[0280] Location: Kheda, Gujarat

[0281] Processing: 11

[0282] Crop age: 60 days after sowing

[0283] Spray volume: 440 liters / hectare

[0284] Method of application: Foliar spraying using a battery-operated backpack sprayer equipped with a hollow cone nozzle.

[0285] Observation method:

[0286] Whitefly (Bemesia tabaci) control (%): The number of live whiteflies (nymphs and adults) was counted per leaf, and observations were recorded for 5 leaves per vine and 5 vines per plot.

[0287]

[0288] T3: Composition of fluoxetine 7% + fluphenazine 8% + orthosilicic acid 2% WG

[0289]

[0290]

[0291] The composition of fluoxetine 7% + flonicamid 8% + orthosilicic acid 2% WG met all internal specifications for both laboratory (at 54±2°C and 0±2°C for 14 days) and room temperature (for 12 months) storage stability studies.

[0292] T3: Manufacturing method for 100kg batch of fluoxetine 7% + flubendiamide 8% + orthosilicic acid 2% WG

[0293] Step 1 - Charge 52.0 kg of china clay, 15.0 kg of corn starch, 0.5 kg of silicone defoamer, 5 kg of sodium isopropylnaphthalene sulfonate, 3 kg of modified polyacrylate copolymer and 7.0 kg of modified sodium lignin sulfonate into a ribbon or premix blender and blend, homogenizing for 30 minutes.

[0294] Step 2 - 7.0 kg of fluoxazolidinone, 8 kg of flonicamid and 2.0 kg of orthosilicic acid were charged and homogenized again for 30 minutes. The pre-blended material was ground by a jet mill / air classifier mill. In addition, the finely ground material was blended in a post-mixer until uniformity was achieved (about 1.5 hours).

[0295] Step 3 - The finely ground powder was mixed with 10 kg of water with 0.5 kg of silicone antifoam to form an extrudable dough.

[0296] Step 4- The mass is passed through an extruder to obtain pellets of desired size.

[0297] Step 5 - The wet granules were passed through a fluid bed dryer to remove the 10 kg of excess water added and further classified using a vibrating screen.

[0298] Step 6- Send the final product for quality control approval.

[0299] Step 7- After approval, the material is packed in the required packing size.

[0300] Table 7: Processing details

[0301]

[0302]

[0303] OD - oil dispersant, WG - water dispersible / wettable granules, T1 to T4 are innovative compositions of the present invention, and T5 to T10 are market products.

[0304] Table 8: Whitefly Control on Cucurbits

[0305]

[0306] All of the inventive compositions (T1 to T4) provided synergistic control of whiteflies infesting cucurbit crops.

[0307] Conclusion: Among the various compositions shown in Table 7, treatment numbers T1 to T4 were considered to be the innovative compositions of the present invention that showed more than 95.4% whitefly control at 7 DAA (days after application) and provided excellent synergistic effect and effectiveness for whitefly control in cucurbits. In particular, when compared with the market products, T4 showed 98.8% whitefly control at 7 DAA, followed by T1 (98.2%) and T2 (96.4%). In addition to this, the colby ratios of T1 to T4 showed greater than 1, demonstrating excellent synergistic effect, compared with other market products.

[0308] Example 5: Control of leafhopper and fruit borer larvae of okra

[0309] Crop: Okra

[0310] Location: Raipur, Chhattishgarh

[0311] Processing: 19

[0312] Crop age: 77 days after sowing

[0313] Spray volume: 490 liters / hectare

[0314] Method of application: Foliar spraying using a battery-operated backpack sprayer equipped with a hollow cone nozzle.

[0315] Observation method:

[0316] Leafhopper (Amrasca biguttula biguttula) control (%): The number of live leafhoppers per leaf was counted and the observations were recorded for 3 leaves per plant and 10 plants per plot. Leafhopper control (%) was calculated. Observations were recorded at 3 DAA and 10 DAA.

[0317] Fruit borer (mixed infestation of Helicoverpa armigera and Spodoptera exigua) larvae control (%): Same as given in Example 1.

[0318] Table 9: Processing details

[0319] Processing number Treatment composition Active ingredient grams / hectare T1 Fluoxathiapiprolin 5% + lambda-cyhalothrin 5% + GA 0.2% EC 25+25+1 T2 Fluoxathiapiprolin 5% + Bifenthrin 8% + GA 0.2% SC 25+40+1 T3 Fluoxathiapiprolin 5% + Cypermethrin 10% + GA 0.2% EC 25+50+1 T4 Fluoxathiapiprolin 5% + Deltamethrin 2% + GA 0.2% EC 25+10+1 T5 Fluoxathiapiprolin 5% + Cypermethrin 6% + GA 0.2% EC 25+30+1 T6 Fluoxathiapiprolin 5% + Lambda-cyhalothrin 5% EC 25+25 T7 Fluoxathiapiprolin 5% + Bifenthrin 8% EC 25+40 T8 Fluoxathiapiprolin 5% + Cypermethrin 10% EC 25+50 T9 Fluoxathiapiprolin 5% + Deltamethrin 2% EC 25+10 T10 Fluoxathiapiprolin 5% + Cypermethrin 6% EC 25+30 T11 Fluoxathiapiprolin 10% EC + Gibberellic acid 40% WSG (tank mixture) 25+1 T12 Fluoxathiocarb 10% EC 25 T13 Gibberellic acid (GA) 40% WSG 1 T14 Lambda Cyhalothrin 5% EC 25 T15 Bifenthrin 10% EC 40 T16 Cypermethrin 10% EC 50 T17 Deltamethrin 11%EC 10 T18 Cypermethrin 10% EC 30 T19 Untreated control (UTC) -

[0320] GA - Gibberellin. T1 to T5 are innovative compositions of the present invention, T6 to T10 are known compositions, T11 is a farm tank mix, and T12 to T18 are market products.

[0321] Table 10: Leafhopper Control in Okra Crops

[0322]

[0323]

[0324] All the inventive inventive compositions (T1 to T5) provided synergistic and residual control of leafhoppers up to 10 days whereas all the known compositions (T6 to T11) provided no residual control and leafhopper control was found to be less than 57.6% at 10 DAA.

[0325] Table 11: Fruit borer larvae control and fruit yield in okra crops

[0326]

[0327] All compositions of the invention (T1 to T5) provided excellent control of fruit borer larvae and also resulted in the production of higher numbers of healthy fruit.

[0328] Conclusion: Among the various compositions shown in Table 9, treatment numbers T1 to T5 are considered to be innovative compositions of the present invention that show excellent synergistic effects and effectiveness against leafhoppers and fruit borer larvae in okra. In addition, T1 to T5 showed more than 96.8% control of leafhoppers at 3DAA (days after application). In particular, T2 showed 99.6% at 3DAA, followed by T1 (98.4%) and T3 (98.2%), demonstrating an effective synergistic effect. In addition, treatment numbers T1 to T5 showed more than 80.4% control of leafhoppers at 10DAA. In particular, T2 showed 85.6% control of leafhoppers at 10DAA, followed by T1 (83.4%) and T3 (82.6%), and also showed a colby ratio greater than 1, which means an effective and stronger synergistic effect.

[0329] Furthermore, T1 to T5 showed more than 83.2% control of fruit borer larvae. In particular, T5 showed 86.2%, followed by T3 (85.85%) and T1 (84.6%). Apart from this, T1 to T5 also showed the number of healthy fruits per plant 10 of more than 43.5. In particular, the number of healthy fruits per plant 10 of T3 was found to be 47.3, followed by T5 (46.1) and T2 (45.2) when compared to farm tank mix and market product. Last but not least, the increase in fruits over UTC (untreated control) was found to be greater than 51.6. In particular, when compared to other known products, farm tank mix and market product, T3 showed an increase in fruits over UTC (untreated control) of 64.8%, followed by T5 (60.6%) and T2 (57.5%).

[0330] Example 6: Sucking Pest Control in Cotton Crops

[0331] Crop: Cotton

[0332] Location: Gondal, Gujarat

[0333] Processing: 11

[0334] Crop age: 70 days after sowing

[0335] Spray volume: 450 liters / hectare

[0336] Method of application: Foliar spraying using a battery-operated backpack sprayer equipped with a hollow cone nozzle.

[0337] Observation method:

[0338] Sucking pests include thrips (Thrips tabaci) and leafhoppers (Amrasca biguttula biguttula). The observation method is the same as that of Experiment No. 5.

[0339]

[0340] T1: Combination of fluoxetine 5% + spirotetramat 10% + paclobutrazol 5% OD

[0341]

[0342] The composition of fluoxetine 5% + spirotetramat 10% + paclobutrazol 5% OD met all internal specifications for both laboratory (at 54±2°C and 0±2°C for 14 days) and room temperature (for 12 months) storage stability studies.

[0343] T1: Manufacturing method for 100kg batch of fluoxathiapiprolin 5% + spirotetramat 10% + paclobutrazol 5% OD

[0344] Step 1: Bentonite clay solution preparation: 15 kg of precipitated silica was added to 85 kg of methylated seed oil and homogenized for 12 to 18 hours before use until it was completely dissolved.

[0345] Step 2: OD premix: Charge 46.0 kg of methylated seed oil into a designated container for preparing OD.

[0346] Step 3: Add 10.0 kg of polyoxyethylene sorbitan hexaoleate, 1.50 kg of styrene acrylic polymer, 8.50 kg of ethoxylated sorbitan ester, 2.50 kg of salt of polyolefin condensate and 0.15 kg of polydimethylsiloxane, and homogenize the contents using a high shear homogenizer for 45 to 60 minutes.

[0347] Step 4: Add 5.0 kg of fluoxetine, 10.0 kg of spirotetramat and 5.0 kg of paclobutrazol to the premix and homogenize for 30 to 45 minutes.

[0348] Step 5: The remaining 0.15 kg of silicon antifoam and 10 kg of 15% silica solution were added after grinding to avoid foaming.

[0349] Step 6: The final formulation is sent for quality control for quality check.

[0350] Table 12: Processing details

[0351]

[0352]

[0353] T1 to T4 are innovative compositions of the present invention, and T5 to T10 are market products.

[0354] Table 13: Sucking insect control and fruiting body counts on cotton

[0355]

[0356] All compositions of the invention (T1 to T4) provided synergistic control of sucking pests of cotton and resulted in the production of a higher number of fruit bodies per plant.

[0357] Conclusion: Among the various compositions shown in Table 12, treatment numbers T1 to T4 are considered to be the innovative compositions of the present invention showing excellent synergistic effects and effectiveness for the control of sucking pests in cotton crops. In addition, T1 to T4 showed more than 94.6% control of sucking pests at 7DAA (days after application). In particular, when compared to other market products, T4 showed 98.8% at 7DAA, followed by T3 (97.2%) and T1 (96.4%). In addition, treatment numbers T1 to T4 showed more than 60.3 fruit bodies per plant. In particular, T4 showed 66.3, followed by T1 (64.7) and T3 (62.9) compared to market products. In addition to this, T1 to T4 also showed an increase of more than 41.5% in fruit bodies relative to T11 [UTC]. In particular, when compared to the market product, T4 showed an increase in fruit size relative to T11 [UTC] of 55.6%, followed by T1 (51.9%) and T3 (47.7%).

[0358] Example 7: BPH (Brown Plant Hopper) Control in Rice

[0359] Crop: Rice

[0360] Location: Rajim, Chhattishgarh

[0361] Processing: 11

[0362] Spray volume: 450 liters / hectare

[0363] Method of application: Foliar spraying using a battery-operated backpack sprayer equipped with a hollow cone nozzle.

[0364] Observation method:

[0365] BPH (Nilaparvata lugens) control: Count the number of live BPH (nymphs + adults) per hill. Record observations for 10 hills per plot. Calculate the percentage of BPH control.

[0366]

[0367] Table 14: BPH control in rice crops

[0368]

[0369] All compositions of the invention (T1 to T4) provide synergistic control of BPH infecting rice crops, T5 to T10 are market products.

[0370] Conclusion: Among the various compositions shown in Table 14, treatment numbers T1 to T4 were considered to be the innovative compositions of the present invention showing excellent synergistic effect and effectiveness against BPH (brown rice planthopper) in rice. Treatment numbers T1 to T4 showed more than 95.2% control of BPH in rice plants at 7 DAA (days after application). In particular, T2 showed 98.8% control of BPH in rice plants, followed by T4 (97.2%) and T1 (96.4%) compared to other products. In addition, it was found that the Colby ratios of the present compositions T1 to T4 were greater than 1, showing an effective synergistic effect.

[0371] Example 8: Larval Control of Marigold

[0372] Crop: Marigold

[0373] Location: Umrat, Gujarat

[0374] Processing: 13

[0375] Spray volume: 400 liters / hectare

[0376] Method of application: Foliar spraying using a battery-operated backpack sprayer equipped with a hollow cone nozzle.

[0377] Observation method:

[0378] Larvae (mixed infestation of Helicoverpa armigera and Spodoptera exigua) control (%): As given in Example 3.

[0379] Table 15: Larvae control on marigold (infesting flowers and leaves)

[0380]

[0381] All compositions of the invention (T1 to T5) provided synergistic control of larvae infesting marigold flowers and foliage. Further visual observations showed that larval control was excellent up to 21 days after application and flower quality was excellent.

[0382] Conclusion: Among the various compositions shown in Table 15, treatment numbers T1 to T5 were considered to be the innovative compositions of the present invention that showed more than 99.2% larval control at 7 DAA (days after application) and showed excellent synergistic effect and effectiveness in controlling larvae (mixed infestation of Helicoverpaarmigera and Spodoptera exigua) in marigold. In particular, when compared with other products, T3, T4 and T5 were demonstrated to have 100% larval control on marigold at 7 DAA, and the colby ratio showed a value greater than 1, demonstrating an effective synergistic effect.

[0383] Overall field trial summary:

[0384] The innovative composition of the present invention comprising fluoxetine, at least one insecticide and at least one plant health additive provides a synergistic effect in insect pest control and residual control, resulting in more fruit, flowers and grains, increased control spectrum and reduced number of insecticide applications under field conditions.

[0385] More specifically, the present invention also relates to the following preferred components:

[0386] Fluoxathiapiprolin 5% + lambda-cyhalothrin 5% + gibberellin 0.2% EC

[0387] Fluoxathiapiprolin 5% + Bifenthrin 8% + Gibberellic acid 0.2% SC

[0388] Fluoxathiapiprolin 5% + Cypermethrin 10% + Gibberellic acid 0.2% EC

[0389] Fluoxathiapiprolin 5% + Deltamethrin 2% + Gibberellic acid 0.2% EC

[0390] Fluoxathiapiprolin 5% + Cypermethrin 6% + Gibberellic acid 0.2% EC

[0391] Fluoxathiazide 6% + Avermectin 1.8% + Gibberellic Acid 0.4% EC

[0392] Fluoxathiapiprolin 3% + Tolfenpyrad 12% + Gibberellic acid 0.2% SC

[0393] Fluoxathiapiprole 6% + Fipronil 9% + Gibberellic acid 0.4% SC

[0394] Fluoxathiapiprolin 6% + methoxazole 9% + gibberellin 0.4% SC

[0395] Fluoxathiapiprolin 6% + Isoxacillin 6% + Gibberellic acid 0.4% SC

[0396] Fluoxathiazide 4% + Emamectin Benzoate 1.8% + Fulvic Acid 1% SC

[0397] Fluoxathiapiprolin 4% + Methoxyfenozide 18% + Fulvic Acid 1% SC

[0398] Fluoxathiazide 4% + Spinosad 10% + Fulvic Acid 1% SC

[0399] Fluoxathiapiprolin 4% + Spinetoram 8% + Fulvic Acid 1% SC

[0400] Fluoxathiazide 4% + Indoxacarb 10% + Fulvic Acid 1% SC

[0401] Fluoxathiapiprolin 10% + Fenpyraclostrobin 5% + Amino Acid 2% SC

[0402] Fluoxathiazide 6% + Hexathiamethoxam 4% + Amino Acid 1.2% SC

[0403] Fluoxathiazide 6% + Ethoxazole 5% + Amino Acid 1.2% SC

[0404] Fluoxathiazide 3% + diafenthiuron 25% + amino acid 0.6% SC

[0405] Fluoxetine 6% + Azadirachtin 1% + Amino Acid 1.2% EC

[0406] Fluoxathiapiprolin 7% + Fluquinoxaline 12% + Orthosilicic Acid 2% SC

[0407] Fluoxathiapiprolin 7% + Diprolin 7% + Orthosilicic Acid 2% OD

[0408] Fluoxathiapiprolin 7% + Fluoxathiapiprolin 8% + Orthosilicic Acid 2% WG

[0409] Fluoxathiazide 3.5% + Pyriproxyfen 7% + Orthosilicic Acid 1% EC

[0410] Fluoxathiapiprolin 5% + Spirotetramat 10% + Paclobutrazol 5% OD

[0411] Fluoxathiapiprolin 5% + Spiroclotamidine 12% + Paclobutrazol 5% OD

[0412] Fluoxathiazide 2.5% + Spiromefant 10% + Paclobutrazol 2.5% SC

[0413] Fluoxetine amide 5% + methoxypiperidin ethyl ester 8% + paclobutrazol 5% SC

[0414] Fluoxathiazide 12% + Pymetrozine 40% + Zinc Lactate-Zinc Gluconate 8% WG

[0415] Fluoxetine 6% + Trifluridine 4% + Zinc Lactate-Zinc Gluconate 4% SC

[0416] Fluoxathiapiprolin 3% + Flufenicol 8% + Zinc Lactate-Zinc Gluconate 2% SC

[0417] Fluoxathiapiprolin 3% + Tolfenpyrad 12% + Zinc Lactate-Zinc Gluconate 2% SC

[0418] Fluoxetine 8% + Emamectin Benzoate 2% + Ascophyllum nodosum Extract 5% SC

[0419] Fluoxetine 8% + Methoxyfenozide 20% + Ascophyllum nodosum extract 5% SC

[0420] Fluoxathiapiprolin 8% + Spinosad 12% + Ascophyllum nodosum extract 5% SC

[0421] Fluoxathiapiprolin 8% + Spinetoram 8% + Ascophyllum nodosum extract 5% SC

[0422] Fluoxathiapiprolin 8% + Indoxacarb 10% + Ascophyllum nodosum extract 5% SC

[0423] Those skilled in the art can modify the method for preparing the novel synergistic composition accordingly based on the knowledge of manufacturing formulations. However, all these changes and modifications are still included in the scope of the present invention.

[0424] Before sowing, directly on the seed or after the seed pre-germination, the seed is applied. Suitable application methods especially include soil treatment, seed treatment, in-ditch application and foliar application. Soil treatment methods include spraying the soil, drip irrigation (drip application on the soil), dipping roots, tubers or bulbs, or soil injection. Seed treatment technology includes seed dressing, seed coating, seed dusting, seed soaking and seed pelleting. In-ditch application generally includes digging trenches on cultivated land, sowing in the trenches, applying the insecticidal active composition in the trenches and closing the trenches. Foliar application refers to applying the insecticidal active composition to plant leaves, for example, by spraying equipment.

[0425] The rates of application vary widely, depending upon the nature of the soil, the method of application, the crop plant, the pest to be controlled, prevailing climatic conditions, and other factors influenced by the method of application, the timing of application, and the target crop.

[0426] Examples of crops for which the insecticidal composition of the present invention can be used include, but are not limited to, cotton (Gossypium spp.), rice (Oryza sativa), wheat (Triticum aestavum), barley (Hordeum vulgare), corn (Zea mays), sorghum (Sorghum bicolor), oats (Avena sativa), pearl millet (Pennisetum glaucum), sugarcane (Saccharum officinarum), sugar beet (Beta vulgaris), soybean (Glycin max), groundnut / peanut (Arachis hypogaea), sunflower (Helianthus annuus), mustard (Brassica juncea), rapeseed (Brassica napus), sesame (Sesamum indicum), mung bean (Vigna radiata), black bean (Vigna mungo), chickpea (Cicer aritinum), cowpea (Vigna unguiculata), red gram (Red gram) (Cajanus cajan), kidney bean (Phaseolus vulgaris), lentil (Lablab purpureus), hard-shell bean (Macrotyloma uniflorum), pea (Pisum sativum), guar (Cyamopsis tetragonoloba), lentil (Lensculinaris), eggplant (Solanum melongena), cabbage (Brassica oleracea var. capitata), cauliflower (Brassica oleracea var. botrytis), okra (Abelmoschus esculentus), onion (Alliumcepa L.), tomato (Solanum lycopersicun), potato (Solanum tuberosum), sweet potato (Ipomoeabatatas), pepper (Capsicum annum), bell pepper (Capsicum annum), garlic (Allium sativum), cucumber (Cucumis sativus), cantaloupe (Cucumis melo), watermelon (Citrullus lanatus), gourd (Lagenariasiceraria), bitter melon (Momordica charantia), radish (Raphanus sativus), carrot (Dacuscarota subsp.sativus), white radish (Brassica rapa rapa), apple (Melus domestica), banana (Musa spp.), citrus (Citrus spp.), grape (Vitis vinifera), guava (Psidium guajava), mango (Mangifera indica), papaya (Carica papaya), pineapple (Ananas comosus), pomegranate (Punica granatum), sapodilla (Manilkara zapota), tea (Camellia sinensis), coffee (Coffea Arabica), turmeric (Curcuma longa), ginger (Zingiber officinale), cumin (Cuminum cyminum), black pepper (Piper nigrum), mint (Mentha spp.), rose (Rosa spp.), jasmine (Jasminum spp.), marigold (Tagetes spp.), daisy (Bellis perennis), dahlia (Dahlia hortnesis), gerbera (Gerbera jamesonii) and carnation (Dianthus caryophyllus) GMO (Genetically Modified Organism) and non-GMO traits, hybrids and conventional varieties.

[0427] Crops are to be understood as also including those crops which have been made tolerant to herbicides or classes of herbicides (e.g. ALS inhibitors, GS inhibitors, EPSPS inhibitors, PPO inhibitors, ACCase inhibitors and HPPD inhibitors) by conventional breeding methods or genetic engineering. Examples of crops which have been made tolerant to imidazolinones (e.g. imazamox) by conventional breeding methods are Summer rapeseed (canola). Crops genetically engineered to be tolerant to herbicides include, but are not limited to, corn varieties resistant to glyphosate and glufosinate, which are available under the trade names and Commercially available.

[0428] Crops are also to be understood as those crops which have been rendered resistant to harmful insects by genetic engineering methods, for example Bt corn (resistant to European corn borer), Bt cotton (resistant to boll weevil) and Bt potato (resistant to Colorado beetle). Bt corn includes (Syngenta Seeds). Bt toxin is a protein produced naturally by the soil bacterium Bacillus thuringiensis. EP-A-451 878, EP-A-374 753, WO 93 / 07278, WO 95 / 34656, WO 03 / 052073 and EP-A-427 529 describe such toxins or transgenic plants capable of synthesizing such toxins. Transgenic plants comprising one or more genes encoding insecticide resistance and expressing one or more toxins are (Corn), Yield (corn), (cotton), (cotton), (potato), and Plant crops or their seed material can be made both resistant to herbicides and resistant to insect feeding ("stacked" transgenic events). For example, seeds can have the ability to express an insecticidal Cry3 protein while being tolerant to glyphosate.

[0429] Crops are also to be understood as including those which have been obtained by conventional breeding or genetic engineering methods and contain so-called output traits, such as improved storage stability, higher nutritional value and improved flavour.

[0430] Other useful plants include turf grasses, such as those grown on golf courses, lawns, parks and roadsides, or grown commercially for lawns, and ornamental plants, such as flowers or shrubs.

[0431] The insecticide composition of the present invention can be used to control insect pests and plant parasitic nematodes. The main insect pests belong to the order Hemiptera, such as but not limited to rice leafhopper / green leafhopper (GLH) (Nephotettix nigropictus), brown rice planthopper (BPH) (Nilaparvata lugen), rice back planthopper (WBPH) (Sogatella furcifera), apple mealybug (Phenococcus aceris), bean aphid (Aphis fabae), orange aphid (Toxoptera aurantii), citrus blackscale (Saissetia oleae), cabbage aphid (Brevicoryne brassicae), false cabbage aphid (Lipaphis erysimi), citrus red scale (Citrus red scale (Aonidiella aurantii), yellow scale (Aonidiella citrine), citrus mealybug (Planococcus citri), corn leaf aphid (Rhopalosiphum maidis), aphids (Aphis gossypii), leafhoppers (Amrasca biguttula), mealybugs (Planococcus spp. and Pseudococcus spp.), cotton stink bugs (Dysdercus suturellus), whiteflies (Bemisia tabaci), cowpea aphids (Aphis crassivora), cereal aphids (Sitobion avenae), golden glow aphid (Uroleucon spp.), grape mealybug (Pseudococcus maritimus), green peach aphid (Myzus persicae), greenhouse whitefly (Trialeurodes vaporariorum), papaya mealybug (Pracoccus marginatus), pea aphid (Acyrthosiphon pisum), sugarcane mealybug (Saccharicoccussacchari), potato aphid (Myzus persicae), potato leafhopper (Empoasca fabae), cotton whitefly (Bemisia tabaci), grass bug (Lygus lineolaris), hairy apple aphid (Eriosoma lanigerum), and mango leafhopper (Amritodus atkinsoni, Idioscopus spp.); Lepidoptera, such as, but not limited to, armyworm (Mythimna unipuncta), Asian rice borer (Chilo suppressalis), bean pod borer (Maruca vitrata), beet armyworm (Spodoptera exigua), black cutworm (Agrotis spp.), ipsilon), stem borer (Helicoverpa armigera), cabbage looper (Trichoplusia ni), apple moth (Cydia pomonella), croton caterpillar (Achea janata), diamond backmoth (Plutella xylostella), cabbage larvae (Pieris rapae), pink bollworm (Pectinophora gossypiella), sugarcane borer (Diatraea saccharalis), sugarcane early shoot borer (Chilo infuscatellus), tobacco armyworm (Heliothis virescens), tomato stem borer (Helicoverpa zea), velvet bean (Anticarsia rapae), gemmatalis), yellow stem borer (Scirpophaga incertulas), spotted stem borer (Earias vittella), rice leaf roller (Cnaphalocrocis medinalis), powdery stem borer (Sesamia spp.), tobacco leaf moth (Spodoptera litura); eggplant tip borer (Leucinodes orbonalis), bean pod borer (Maruca vitrata, Maruca pod borer)testulalis), armyworm (Mythimna separata), citrus leafminer (Phyllocnistis citrella), cabbage butterfly (Pieris brassicae), rice stem borer (Scirpophaga excerptallis, Scirpophaga incertulas, Scirpophaga innotata), wheat stem borer (Sesamia inferens, Sitotrogacerealella, Spilosoma obliqua), and fall armyworm (Spodoptera frugiperda, Spodoptera littoralis, Spodoptera litura), sugarcane borer (Tryporyza nivella), sharp-winged rice dream moth (Tryporyza incertulas, tomato leafminer (Tuta absoluta); Coleoptera, such as, but not limited to, apple twig borer (Amphicerus spp.), corn rootworm (Diabrotica virgifera), cucumber beetle (diabrotica balteata), pod weevil (Anthonomus grandis), grape flea beetle (Altica chalybea), grape rootworm (Fidia viticola), grape stem borer (Clytoleptus albofasciatus), radish flea beetle (horseradish flea beetle (Phyllotreta armoraciae), corn weevil (Sitophilus zeamais), northern corn rootworm (Diabrotica barberi), rice water weevil (Lissorhoptrus oryzophilus), cotton boll weevil (Anthonomus grandis), grandis), European lentil weevil (Bruchuslentis), eleven-spotted rootworm (Diabrotica semipunctata), corn rootworm (Diabroticavirgifera), rice ironclad beetle (Dicladispa armigera), Mexican bean beetle (Epilachnavarivestis), and various species of white grubs (Holotrichia bicolor, Holotrichiaconsanguinea, Holotrichia serrata, Leptinotarsa ​​decemlineata, Phyllotreta chrysocephala, Popillia japonica); Orthoptera, such as, but not limited to, Gryllotalpa spp., Locusta spp., and Schistocerca spp.; Thysanoptera, such as, but not limited to, Frankliniella spp., Thrips palmi, Thrips tabaci, and Scirtothrips dorsalis; Termitomyces (Isoptera), such as, but not limited to, Calotermes flavicollis, Coptotermes formosanus, Heterotermes aureus, Leucotermes flavipes, Microtermes obesi, Odontotermes obesus, Reticulitermes flavipes, and Termes natalensis; Heteroptera, such as, but not limited to, Dysdercus spp. and Leptocorisa spp.; Hymenoptera, such as, but not limited to, Solenopsis spp.; Diptera, such as, but not limited to, Antherigona soccata, Dacus spp., Liriomyza spp., and Melanagromyza spp.; Acarina, such as, but not limited to, Aceria mangiferae, Brevipalpus spp., Eriophyes spp., Oligonychus mangiferus), Oligonychus punicae, Panonychus citri, Panonychus ulmi, Polyphagotarsonemus latus, Tarsonemus spp., Tetranychus urticae, and Tetranychus cinnabarinus.cinnabarinus); plant parasitic nematodes such as, but not limited to, root-knot nematodes (Meloidogyne incognita, Meloidogyne javanica, and other Meloidogyne species); cyst nematodes (Globodera rostochiensis, Globodera pallida, Globodera tabacum, and other Globodera species, Heterodera avenae, Heterodera glycines, Heterodera schachtii, Heterodera trifolii, and other Heterodera species); seed gall nematodes (Anguina funesta, Anguina tritici and other Anguina species); stem and leaf nematodes (Aphelenchoides besseyi, Aphelen-choides fragariae, Aphelenchoides ritzemabosi and other Aphelenchoides species); sting nematodes (Belonolaimus longicaudatus and other Belonolaimus species); pine nematodes (Bursaphelenchus xylophilus and other Bursaphelenchus species); ring nematodes (Criconema species, Criconemella species, Criconemoides species and Mesocriconema species); stem and bulb nematodes (Ditylenchus spp. nematodes) (Ditylenchus destructor, Ditylenchus dipsaci, Ditylenchus myceliophagus and other Ditylenchus species); trypanosomes (Dolichodorus species), spiral nematodes (Helicotylenchusdihystera, Helicotylenchus multicinctus and other Helicotylenchus species; Rotylenchus robustus and other Rotylenchus species); sheath nematodes (Hemicycliophora species and Hemicriconemoides species); Hirshmanniella species; lance nematodes (Hoplolaimus columbus, Hoplolaimus galeatus and other Hoplolaimus species); pseudo-root-knot nematodes (Nacobbus aberrans and other Nacobbus species); needle nematodes (Longidorus elongates and other Longidorus species); pin nematodes (Paratylenchus species); lesion nematodes (Pratylenchus brachyurus, Pratylenchus coffeae, Pratylenchus curvitatus, Pratylenchus goodeyi, Pratylenchus neglectus, Pratylenchus penetrans, Pratylenchus scribneri, Pratylenchus vulnus, Pratylenchus zeae and other Pratylenchus species, Radinaphelenchus cocophilus and other Radinaphelenchus species); burrowing nematodes (Radopholus similis and other Radopholus species); reniform nematodes (Rotylenchulus reniformis and other Rotylenchulus species), Scutellonema species; short and thick root nematodes (Trichodorusprimitivus and other Trichodorus species, Paratrichodorus minor and other Paratrichodorus species); dwarf nematodes (Tylenchorhynchus claytoni, Tylenchorhynchus dubius and other Tylenchorhynchus species, and Merlinius species); citrus nematodes (Tylenchulus semipenetrans and other Tylenchulus species); Xiphinema (Xiphinema americanum, Xiphinema index, Xiphinema diversicaudatum and other Xiphinema species); and other plant parasitic nematode species.

[0432] It is noteworthy that when applying the composition of the invention, the health of the plant is enhanced, regardless of the insecticidal properties of the active ingredients used, because the enhancement of health is not based on a reduction in pest pressure, but on complex physiological metabolic reactions, which, for example, lead to the activation of the plant's own natural defense system. As a result, the health of the plant is enhanced even in the absence of pest pressure. Thus, the health of the plant is enhanced regardless of the presence of biotic or abiotic stress factors.

[0433] The indicators of plant health confirmed above can be interdependent, or they can be the result of interaction. The increase of plant vigor for example causes output and / or increases tolerance to abiotic or biotic stresses. The feature of output increase can be especially the following improved properties of plant: plant weight increases, plant height increases, biomass increases such as total fresh weight (FW) is higher, the number of flowers per plant increases, grain yield is higher, tillers or lateral branches (branching) are more, leaves are larger, branch growth increases, protein content increases, oil content increases, starch content increases, pigment content increases and leaf area index increases.

[0434] According to the present invention, compared with untreated control plants or plants treated with known conventional pesticides, the yield is increased by at least 4%, preferably 5% to 10%, more preferably 10% to 20%, or even 30% to 50% or even more. Generally, the yield increase can be even higher.

[0435] Another indicator of plant condition is plant vigor. Plant vigor is manifested in several aspects, such as overall visual appearance. Plant vigor of plants treated with the compositions of the present invention is synergistically increased. Improved plant vigor may be characterized, inter alia, by improved properties of the plant, such as improved vitality of the plant, improved plant growth, improved plant development, improved visual appearance, improved plant stand (less verse / lodging of the plant), improved emergence, enhanced root growth and / or more developed root system, enhanced nodulation (particularly rhizobium nodulation), larger leaves, larger size, increased plant weight, increased plant height, increased number of tillers, increased number of lateral branches, increased number of flowers per plant, increased shoot growth, increased root growth (very large root system), increased yield when grown in poor soils or adverse climates, enhanced photosynthetic activity (e.g. based on increased stomatal conductance and / or increased CO2 assimilation rate), increased stomatal conductance, increased CO2 assimilation rate, increased pigment content (e.g. chlorophyll content), earlier flowering, earlier fruiting, earlier and improved germination, earlier grain maturity, self-defense Improved mechanisms, improved stress tolerance and resistance of plants to biotic and abiotic stress factors (e.g., fungi, bacteria, viruses, insects, heat stress, cold stress, drought stress, UV stress and / or salt stress), fewer non-productive tillers, fewer dead basal leaves, fewer inputs required (e.g., fertilizer or water), greener leaves, full maturity in a shortened vegetative period, less fertilizer required, fewer seeds required, easier to harvest, faster and more uniform maturity, longer shelf life, longer ears, delayed senescence, stronger and / or more productive tillers, better extractability of components, improved seed quality (for sowing in the following season to produce seeds), better nitrogen uptake, better reproduction, reduced production of ethylene and / or inhibition of ethylene uptake by the plant.

[0436] Improvement of plant vigor according to the invention means in particular that any one, several or all of the above-mentioned plant characteristics are improved irrespective of the insecticidal action of the mixture or the active ingredients (components).

[0437] Another indicator of the condition of a plant is the "quality" of the plant and / or its products. The quality of plants treated with the composition of the invention is synergistically increased.

[0438] According to the invention, improved quality means that certain plant characteristics, such as the content or composition of certain components, are increased or improved by a measurable or perceptible amount relative to the same factors produced by the plant under the same conditions but without the application of the composition of the invention. The improved quality may be characterized in particular by the following improved properties of the plant or its products, such as increased nutrient content, increased protein content, increased fatty acid content, increased metabolite content, increased carotenoid content, increased sugar content, increased amount of essential amino acids, improved nutrient composition, improved protein composition, improved fatty acid composition, improved metabolite composition, improved carotenoid composition, improved sugar composition, improved amino acid composition, improved or optimized fruit color, improved leaf color, higher storage capacity, higher processability of the harvested product.

[0439] Another indicator of plant condition is the tolerance or resistance of plants to biotic and / or abiotic stress factors. Biological and abiotic stress, especially long-term biotic and abiotic stress, can have a harmful effect on plants. Biological stress is caused by organisms, while abiotic stress is caused, for example, by extreme conditions of the environment. According to the present invention, "enhanced tolerance or resistance to biotic and / or abiotic stress factors" means that (1.) certain negative factors caused by biotic and / or abiotic stress are reduced in a measurable or perceptible amount compared to plants exposed to the same conditions but not treated with the composition of the present invention, and (2.) the negative effects are not reduced by the direct action of the composition of the present invention on the stress factors (e.g., by its insecticidal action of directly destroying microorganisms or pests), but by stimulating the plant's own defense response to the stress factors.

[0440] The compositions of the present invention provide many benefits, for example, synergistic control of insect pests and mites in a single application; residual control (i.e., longer duration control) and direct crop protection; delayed development of resistance and effective control of hard-to-kill and resistant insect pests and mites; increased yield of treated plants (cereals, pulses, oilseeds, fiber crops, sugar crops, leafy vegetables, tuber crops, fruit crops, flowers, ornamentals, etc.); increased yield due to protection against insect pests and mites; increased yield due to plant growth regulation and increased reproductive parts of the plant; increased yield due to more tillers, more branches and sub-branches, more flowers Increase the number of flowers and fruits; increase plant vigor; increase tolerance to damage by insect pests and mites; increase tolerance to weather stress and water stress; prevent lodging of susceptible plants due to biotic and abiotic factors such as heavy rain, wind, insect and disease damage; improve the quality (meaning visual appearance, color, size, shape, etc.) of grains, fruits, fibers, flowers, tubers, bulbs, rhizomes, straw, leaves and other plant parts and plant products; improve the keeping properties of agricultural products, extend the post-harvest life, storage period, protect against post-harvest diseases; uniformize the size of tubers, bulbs, rhizomes and root crops.

[0441] The present invention has been described with reference to specific embodiments, which are merely illustrative and are not intended to limit the scope of the invention as defined in this complete specification.

Claims

1. A fluoxathiocarbamide composition comprising: A) 1 to 40 w / w% amount of fluoxathiocarbamide; B) at least one or more compounds selected from the group consisting of insecticides in an amount of 1 to 40 w / w %; and C) at least one or more compounds selected from plant health additives in an amount of 0.001 to 20 w / w%, and an agrochemically acceptable excipient.

2. The oxazolidinone amide composition according to claim 1, wherein B) The insecticide is selected from lambda cyhalothrin, bifenthrin, cypermethrin, deltamethrin, cypermethrin, avermectin, tolfenpyrad, fipronil, methoprene, isoxathiapiprolin, emamectin benzoate, methoxyfenozide, spinosad, spinetoram, indoxacarb, fenpyroximate, hexythiazolin, etoxazole, diafenthiuron, azadirachtin, pyrifoquinoxaline, bicyclanil, flonicamid, pyriproxyfen, spirotetramat, spirodiclofen, spiromesifen, methoxyfenopyrim, pymetrozine, triflumuron and flufenoxam.

3. The fluoxazole amide composition according to claim 2, wherein More preferably the insecticide of compound B is present in the range of 1% to 40%.

4. The fluoxathiocarbamide composition according to claim 1, wherein The plant health care additive used for compound C is selected from gibberellins, fulvic acid, amino acids, orthosilicic acid, paclobutrazol, zinc lactate-zinc gluconate, and Ascophyllum nodosum extract.

5. The fluorooxazole amide composition according to claim 4, wherein The amino acid used for compound C is selected from alanine, arginine, aspartic acid, cysteine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine and mixtures thereof.

6. The fluoxathiazole amide composition according to claim 4, wherein More preferably the plant health supplement of compound C is present in the range of 0.2% to 8%.

7. The fluoxazolidinone amide composition according to claim 1, wherein The agrochemically acceptable excipient is selected from dispersants, antifreeze agents, defoamers, wetting agents, suspension aids and carriers, antimicrobial agents, thickeners, colorants, rapid coating agents or adhesives, polymers, disintegrants, oil additives, buffers and solvents.

8. The fluoxazole amide composition according to claim 6, wherein The agrochemically acceptable excipient is present in the range of 0.1% to 99% by weight of the total composition.

9. The fluoxathiocarbamide composition according to claim 1, wherein The compositions are in the form of oil dispersions (OD), wettable granules (WG), emulsifiable concentrates (EC) and suspension concentrates (SC).

10. The fluorooxazole amide composition according to claim 1 or 8, wherein The wetting agent for the oil dispersant (OD) is selected from ethylene oxide / propylene oxide block copolymers, polyaryl phenyl ether phosphates, ethoxylated fatty alcohols, sodium dioctyl sulfosuccinate, sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, alkyl dibenzene sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonates and mixtures thereof.

11. The fluorooxazole amide composition according to claim 1 or 8, wherein The wetting, diffusing and penetrating agent for the oil dispersant (OD) is selected from the group consisting of silicone surfactant trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methylpolysiloxane, polyoxyalkylene methylpolysiloxane, polyether polymethylsiloxane copolymer, heptamethyltrisiloxane, polyoxyalkylene-modified heptamethyltrisiloxane, polyether-modified polysiloxane, and unmodified forms and mixtures thereof.

12. The fluorooxazole amide composition according to claim 1 or 8, wherein Emulsifiers for oil dispersants (OD) are selected from castor oil ethoxylates, alcohol ethoxylates, fatty acid ethoxylates, sorbitan ester ethoxylates, sulfosuccinates, calcium salts of dodecylbenzene sulfonates, alkylammonium salts of alkylbenzene sulfonates, alkyl sulfosuccinates, ethylene oxide-propylene oxide block copolymers, ethoxylated alkylamines, ethoxylated alkylphenols, polyoxyethylene sorbitan monolaurate and mixtures thereof.

13. The fluorooxazole amide composition according to claim 1 or 8, wherein The dispersant used for the oil dispersant (OD) is selected from the group consisting of salts of alkyl sulfonates, alkylbenzene sulfonates, alkylaryl sulfonates, alkylphenol alkoxylates, tristyrylphenol ethoxylates, natural or synthetic fatty ethoxylated alcohols, natural or synthetic fatty acid alkoxylates, natural or synthetic fatty alcohol alkoxylates, alkoxylated alcohols, n-butyl alcohol polyglycol ethers, block copolymers, ethylene oxide-propylene oxide block copolymers, ethylene oxide-butylene oxide block copolymers, fatty acid-polyalkylene glycol condensates, polyamine-fatty acid condensates, polyester condensates, polyolefin condensates. , sodium lignin sulfonate, sodium polycarboxylate, EO / PO-based copolymers, phenol sulfonate, sodium methyl oleyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide copolymer, polyethylene glycol 2,4,6-tristyryl phenyl ether, tristyrylphenol-polyethylene glycol ether-phosphate, tristyrylphenol with 16 moles of EO, tristyrylphenol-polyethylene glycol ether-phosphate, oleyl polyethylene glycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyethylene glycol ether with 9 to 10 moles of ethylene oxide, and mixtures thereof.

14. The fluorooxazole amide composition according to claim 1 or 8, wherein The stabilizer for the oil dispersant (OD) is selected from the group consisting of hectorite clay, aluminum magnesium silicate, bentonite clay, silica, attapulgite clay, and mixtures thereof.

15. The fluorooxazole amide composition according to claim 1 or 8, wherein The defoamer for oil dispersant (OD) is selected from silicone oil, organosilicon compound, C 10 ~C 20 Saturated fatty acid compounds or C8~C 10 Fatty alcohol compounds, silicone antifoam emulsions, dimethylsiloxanes, polydimethylsiloxanes, vegetable oil-based antifoaming agents, animal fat-based fatty acids, polyoxyalkylene-modified polydimethylsiloxanes, and mixtures thereof.

16. The fluorooxazole amide composition according to claim 1 or 8, wherein The antifreeze agent used in the oil dispersion (OD) is selected from ethylene glycol, propylene glycol, glycerine or urea, glycol, monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol, glycerine, urea, magnesium sulfate heptahydrate, sodium chloride and mixtures thereof.

17. The fluorooxazole amide composition according to claim 1 or 8, wherein The preservative used in the oil dispersant (OD) is selected from 1,2-benzisothiazolin-3(2H)-one (sodium salt), sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenylphenol, 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one and mixtures thereof.

18. The fluorooxazole amide composition according to claim 1 or 8, wherein The solvent for the oil dispersant (OD) is selected from vegetable oil (plant, seed or tree) or its alkylate or ethoxylate or ester; alkylated vegetable oil, methylated vegetable oil or ethylated vegetable oil; olive oil, kapok oil, castor oil, papaya oil, camellia oil, sesame oil, corn oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, rapeseed mustard oil, linseed oil, tung oil, sunflower oil, safflower oil, coconut oil; methyl, ethyl, propyl or butyl esters of vegetable oil, methylated seed oil, polyoxyalkylene-modified polydimethylsiloxane alkyl Phenol ethoxylate, rapeseed oil methyl ester, rapeseed oil ethyl ester, rapeseed oil propyl ester, rapeseed oil butyl ester, soybean oil methyl ester, soybean oil ethyl ester, soybean oil propyl ester, soybean oil butyl ester, castor oil methyl ester, castor oil ethyl ester, castor oil propyl ester, castor oil butyl ester, cottonseed oil methyl ester, cottonseed oil ethyl ester, cottonseed oil butyl ester, cottonseed oil propyl ester, tall oil fatty acid esters - animal fat methyl ester, animal fat ethyl ester, animal fat propyl ester, biodiesel, mineral oil, aromatic solvents, isoparaffin, alkaline solvents, fatty acid amides, C1-C3 amines, alkylamines or C6-C 18 Alkanolamines of carboxylic acids, fatty acids, alkyl esters of fatty acids, methyl and ethyl oleate, methyl and ethyl soyalate, alkylbenzenes, alkylnaphthalenes, polyalkylene glycol ethers, fatty acid diesters, fatty alkyl amides and diamides, diene carbonates, ketones, alcohols and mixtures thereof.

19. The fluorooxazole amide composition according to claim 1 or 8, wherein The cosolvent for the oil dispersant (OD) is selected from cyclohexanone, acetophenone, NMP, dimethyl sulfoxide, benzyl alcohol, butanol, N-octanol, N-propanol, 2-ethylhexanol, tetrahydrofurfuryl alcohol, isophorone, fatty acid dimethylamide, 2-hexylethyl lactate, propylene carbonate and mixtures thereof.

20. The fluoxathiazole amide composition according to claim 1 or 8, wherein The dispersant used in wettable granules (WG) is selected from sodium polycarboxylate, sodium polyacrylate, sodium naphthalene sulfonate formaldehyde condensate, polyalkoxylated alkylphenol, naphthalene sulfonic acid formaldehyde condensate, methyl naphthalene-formaldehyde condensate sodium salt, naphthalene condensate, lignin sulfonate, calcium lignin sulfonate, lignin sulfonate sodium salt, alkyl naphthalene sulfonate (sodium salt) and mixtures thereof.

21. The fluorooxazole amide composition according to claim 1 or 8, wherein The wetting agent for wettable granules (WG) is selected from sodium N-methyl-N-oleyl taurate, alkylated naphthalene sulfonates (sodium salt), a mixture of isomers of dibutylnaphthalene sulfonic acid sodium salt, sodium diisopropylnaphthalene sulfonate, sodium dodecyl sulfate, dioctyl sulfate, alkylnaphthalene sulfonates, phosphates, sulfosuccinates, nonionic tridecyl alcohol ethoxylates, alkyl or alkaryl sulfonates, alkylbenzene sulfonates, α-olefin sulfonates, alkylnaphthalene sulfonates, ethoxylated or non-ethoxylated alkyl or alkaryl carboxylates, alkyl or alkaryl phosphates, alkyl polysaccharides, di- or monoalkyl sulfosuccinate derivatives, α-olefin sulfonates, alkylnaphthalene sulfonates, dialkyl sulfosuccinates, butylnaphthalene sulfonates, dibutylnaphthalene sulfonates, isopropylnaphthalene sulfonates, diisopropylnaphthalene sulfonates, C 12 Alkylbenzene sulfonate or C 10 -C 16 Alkylbenzene sulfonates, silicone surfactants, trisiloxane ethoxylates, polydimethylsiloxanes, polyoxyethylene methylpolysiloxanes, polyoxyalkylene methylpolysiloxanes, polyether polymethylsiloxane copolymers, heptamethyltrisiloxane, polyoxyalkylene-modified heptamethyltrisiloxane, polyether-modified polysiloxanes, and unmodified forms and mixtures thereof.

22. The fluoxazolidinone amide composition according to claim 1 or 8, wherein The defoamer used for wettable granules (WG) is polydimethylsiloxane.

23. The fluoxazole amide composition according to claim 1 or 8, wherein The carrier for wettable granules (WG) is selected from china clay, silica, anhydrous lactose, ammonium sulfate, anhydrous sodium sulfate, corn starch, urea, EDTA, urea-formaldehyde resin, diatomaceous earth, kaolin, bentonite, mortar, fuller's earth, attapulgite clay, tree trunks, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesium oxide, magnesium oxide, magnesium sulfate, sodium chloride, gypsum, calcium sulfate, pyrophyllite, silicates, silica gel, ammonium sulfate, ammonium phosphate, ammonium nitrate, urea, natural products of plant origin, cereal grains, cereal powder, bark powder, wood powder, husk powder, cellulose powder, synthetic polymer materials, ground or powdered plastics and resins, bentonite, zeolite, titanium dioxide, iron oxide, iron hydroxide, aluminum oxide, aluminum hydroxide, or organic materials, bagasse, charcoal, or synthetic organic polymers, and mixtures thereof.

24. The fluoxazolidinone amide composition according to claim 1 or 8, wherein: The humectant used in wettable granules (WG) is selected from humic acid, glycerol, lactose, anhydrous sodium sulfate and mixtures thereof.

25. The fluorooxazole amide composition according to claim 1 or 8, wherein The solvent for the emulsifiable concentrate (EC) is selected from aromatic hydrocarbons, C-9, toluene, o-xylene, m-xylene, p-xylene, dodecane, n-decane, n-hexane, benzene, ethylbenzene, isopropylbenzene, tert-butylbenzene, naphthalene, monoalkyl or polyalkyl substituted naphthalene, depleted heavy aromatic naphthalene (aromatic 200, 100, 150), n-butanol, N-methyl-2-pyrrolidine, methanol, ethanol, n-propanol, isopropyl alcohol, n-butanol, tert-butanol, paraffin, cyclohexanone, isophorone, ester solvents, methyl oleate, C6-C 16 Dimethylamide and morpholineamide derivatives of fatty acids, monoolefin carbonate, ethylene carbonate, propylene carbonate, butylene carbonate, dimethyl sulfoxide (DMSO), 2-ethylhexanol, n-butanol, n-alkylpyrrolidone, fatty acid dimethyl esters, fatty acid esters, dibasic esters, aromatic hydrocarbons, aliphatic hydrocarbons, one or more dimethylamides, C8-dimethylamide, C 10 -Dimethylamine, C 12 -dimethylamide, ethylene glycol, propylene glycol, polyalkylene glycol, methyl pyrrolidone (NMP), N,N-decylamide, dimethylformamide (DMF), dimethyl isosorbide (DMI), isophorone, acetophenone, 1,3-dimethyl-2-imidazolidinone, lactic acid esters, dimethyl carbonate and diethyl carbonate, alcohols, methanol, ethanol, isopropanol, n-propanol, n-butanol, isobutanol, tert-butanol, methyl L-lactate, 2-ethylhexyl L-lactate, ethyl L-lactate, n-butyl L-lactate, octylphenyl ethoxylate and mixtures thereof.

26. The fluoxazolidinone amide composition according to claim 1 or 8, wherein The emulsifier used for the emulsifiable concentrate (EC) is selected from: dodecylbenzene sulfonate, calcium salt or amine salt, other C 11 -C 16 Alkylbenzene sulfonates, alkyl ether sulfates, alkylphenol ether phosphates, emulsifiers of ester phosphates, nonionic surfactants, alkoxylated alcohols, alkylphenols, ethoxylated fatty acids, ethoxylated vegetable oils, ethoxylated castor oils, fatty acid esters, sorbitol, ethoxylated derivatives of sorbitol, ethoxylated amines, condensates of glycerol, anionic and cationic emulsifiers, cationic amines, alkyl sulfonates, ether sulfonates, ether phosphates, alkoxylated alcohols, alkoxylated alkylphenols, ethoxylated fatty acids, ethoxylated vegetable oils, ethoxylated tristyrylphenols, fatty acid esters of sorbitol and their ethoxylated derivatives; condensates of ethoxylated amines, glycerol, C 11 -C 16 Sulfonated alkylbenzenes and their salts within the scope; alkyl ether sulfates; alkyl ether phosphates; alkylphenol ether phosphates; and combinations thereof; salts of phosphate esters of ethoxylated tristyrylphenol; salts of sulfated ethers of ethoxylated tristyrylphenol; combinations of cationic amines with alkyl sulfonates, alkyl ether sulfonates, ether sulfates or ether phosphates (alkyl ether phosphates), polyadducts of nonylphenol polyethoxyethanol, castor oil polyglycol ether, ethylene oxide and polypropylene; tributylphenoxypolyethoxyethanol, octylphenoxypolyethoxyethanol, calcium alkylbenzene sulfonate sodium salt, polyarylphenyl anionic ether sulfate ammonium salt and mixtures thereof.

27. The fluoxazole amide composition according to claim 1 or 8, wherein The adhesive, surface tension reducer and binder used in the emulsifiable concentrate (EC) is polyvinyl pyrrolidone.

28. The fluoxazole amide composition according to claim 1 or 8, wherein The dispersants, adhesives, penetrants and surface tension reducers used in emulsifiable concentrates (EC) are alkyl polyglycol ethers.

29. The fluoxazole amide composition according to claim 1 or 8, wherein The superwetting diffusing penetrant used in the emulsifiable concentrate (EC) is polyoxyalkylene-modified heptamethyltrisiloxane.

30. The fluoxazolidinone amide composition according to claim 1 or 8, wherein The wetting agent for suspension concentrates (SC) is selected from ethylene oxide / propylene oxide block copolymers, polyaryl phenyl ether phosphates, polyalkoxylated butyl ethers, ethoxylated fatty alcohols, sodium dioctyl sulfosuccinate, sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, alkyl dibenzene sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonates, silicone surfactants, trisiloxane ethoxylates, polydimethylsiloxanes, polyoxyethylene methylpolysiloxanes, polyoxyalkylene methylpolysiloxanes, polyether polymethylsiloxane copolymers, heptamethyltrisiloxane, polyoxyalkylene-modified heptamethyltrisiloxane, polyether-modified polysiloxanes, polyoxyalkylene-modified trisiloxanes, polyoxyalkylene-modified polydimethylsiloxanes, trisiloxane ethoxylates, polyoxyethylene methylpolysiloxanes, polyether polymethylsiloxane copolymers, polyether-modified polysiloxanes; and unmodified forms and mixtures thereof.

31. The fluoxazolidinone amide composition according to claim 1 or 8, wherein Dispersants for suspension concentrates (SC) are selected from sodium naphthalenesulfonate formaldehyde condensate, alkylated naphthalenesulfonates (sodium salt), sodium salt of naphthalenesulfonic acid condensate, sodium lignin sulfonate, sodium polycarboxylate, EO / PO based copolymers, phenol sulfonates, sodium methyl oleyl taurate, styrene acrylic acid copolymers, propylene oxide-ethylene oxide copolymers, polyethylene glycol 2,4,6-tristyryl phenyl ether, tristyrylphenol-polyethylene glycol ether-phosphate, tristyrylphenol with 16 moles of EO, tristyrylphenol-polyethylene glycol ether-phosphate, oleyl polyethylene glycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyethylene glycol ether with 9 to 10 moles of ethylene oxide, and mixtures thereof.

32. The fluoxazole amide composition according to claim 1 or 8, wherein The suspending agent used in the suspension concentrate (SC) is selected from the group consisting of magnesium aluminum silicate, bentonite clay, silica, attapulgite clay and mixtures thereof.

33. The fluoxazolidinone amide composition according to claim 1 or 8, wherein The defoamer for suspension concentrate (SC) is selected from silicone oil, organosilicon compound, C 10 ~C 20 Saturated fatty acid compounds or C8~C 10 Fatty alcohol compounds, silicone antifoam emulsions, dimethylsiloxanes, polydimethylsiloxanes, vegetable oil-based antifoaming agents, animal fat-based fatty acids, polyoxyalkylene-modified polydimethylsiloxanes, and mixtures thereof.

34. The fluoxazolidinone amide composition according to claim 1 or 8, wherein The antifreeze agent used for suspension concentrate (SC) is selected from ethylene glycol, propylene glycol, glycerine or urea, glycol, monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol, glycerine, urea, magnesium sulfate heptahydrate, sodium chloride and mixtures thereof.

35. The fluoxazole amide composition according to claim 1 or 8, wherein The preservative used in the suspension concentrate (SC) is selected from 1,2-benzisothiazolin-3(2H)-one (sodium salt), sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenylphenol, 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one and mixtures thereof.

36. The fluoxazole amide composition according to claim 1 or 8, wherein The thickener used for the suspension concentrate (SC) is selected from the group consisting of xanthan gum, PVK, carboxymethyl cellulose, polyvinyl alcohol, gelatin, sodium carboxymethyl cellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch, gum arabic and mixtures thereof.

37. The fluoxazolidinone amide composition according to claim 1 or 8, wherein The humectant used in the suspension concentrate (SC) is selected from urea, humic acid, glycerol, lactose and mixtures thereof.

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