Automatic feeding system for production of glycerophosphorylcholine capsules

Abstract

The invention belongs to the field of application equipment for production of glycerophosphorylcholine, and particularly relates to an automatic feeding system for production of glycerophosphorylcholine capsules. Comprising a powder discharging device and a metering and filling device arranged below the powder discharging device, the metering and filling device comprises a metering barrel arranged in a rotating mode and a filling seat arranged above the metering barrel, a filling rod is arranged on the filling seat, a metering hole matched with the filling rod is formed in the bottom of the metering barrel, and the metering barrel is arranged in the metering hole. The structures of the powder feeding device and the metering and filling device are improved on the basis of an existing automatic capsule filling machine, so that the purposes of drying and dispersing glycerophosphorylcholine are achieved, the hardening problem caused by the moisture absorption characteristic of glycerophosphorylcholine and the influence on the filling effect are avoided, and meanwhile, the production efficiency is improved. The automatic feeding system for the glycerophosphorylcholine capsule production mainly depends on an existing power structure, double-function output is achieved, the improvement cost is low, and the automatic feeding system is suitable for large-scale application and popularization.

Description

Technical Field

[0001] The invention belongs to the field of glycerol phosphorylcholine production and application equipment, and in particular relates to an automatic feeding system for glycerol phosphorylcholine capsule production. Background Art

[0002] Choline glycerol is a naturally occurring intermediate in phospholipid metabolism in the human body. It exists in cells and is distributed throughout the human body. It is composed of choline, glycerol, and phosphoric acid. It is a major form of choline storage and is recognized as a source of choline. Because it is an endogenous substance, its toxic side effects are extremely low. After absorption, choline glycerol is decomposed into choline and glycerol phosphate by the action of enzymes in the body: choline participates in the biosynthesis of acetylcholine, which is a type of neurotransmitter; glycerol phosphate is the precursor of lecithin and participates in the synthesis of lecithin. The main pharmacological effects include protecting the metabolism of choline, ensuring the synthesis of acetylcholine and lecithin in the nerve membrane, improving blood circulation, and improving cognitive and behavioral responses for patients with damaged capillaries in the brain.

[0003] Glycerylphosphorylcholine is miscible with water, soluble in methanol and ethanol, insoluble in chloroform, ether, oil, etc., and has no characteristic absorption under ultraviolet and visible light. At room temperature, glycerylphosphorylcholine is in the form of solid powder. Therefore, glycerylphosphorylcholine can be contained in capsules.

[0004] The existing glyceryl phosphoryl choline capsules mainly have automatic capsule filling machines to achieve filling and filling. The automatic capsule filling machine can realize the automatic filling of glyceryl phosphoryl choline and realize automated production, but glyceryl phosphoryl choline has a very hygroscopic property, and the relatively ideal conditions for capsule filling are 35-65% humidity and 15-25°C temperature. If the humidity or temperature is too low, the capsule will become brittle and easy to crack; if the humidity is too high, the capsule will become sticky and deformed, and if the temperature is too high, the capsule will be thermally damaged. As a result, it is impossible to effectively realize automated filling. Therefore, in order to ensure the assembly of the capsule, the temperature and humidity of the workshop are generally set according to the ideal conditions of the capsule, and the high humidity may cause the glyceryl phosphoryl choline to absorb moisture and harden in the feeding system, which also affects the normal filling. Summary of the invention

[0005] Aiming at the technical problem existing in an automatic capsule filling machine due to the high hygroscopicity of glycerol phosphoryl choline, the invention proposes an automatic feeding system for producing glycerol phosphoryl choline capsules which has reasonable design, simple structure, convenient processing and can effectively solve the hygroscopicity problem of glycerol phosphoryl choline.

[0006] In order to achieve the above-mentioned purpose, the technical solution adopted by the present invention is as follows: the present invention provides an automatic feeding system for the production of glyceryl phosphorylcholine capsules, comprising a powder feeding device and a metering and filling device arranged below the powder feeding device, wherein the metering and filling device comprises a rotatably arranged metering barrel and a filling seat arranged above the metering barrel, a filling rod is arranged on the filling seat, a metering hole matched with the filling rod is arranged at the bottom of the metering barrel, a fixed seat is further arranged between the filling seat and the metering barrel, the filling seat is lifted and arranged above the fixed seat, and the middle parts of the filling seat and the fixed seat are both provided with A through hole for unloading materials, a material guide hood is arranged at the bottom of the metering barrel, the material guide hood includes a top plate and a side plate arranged at the edge of the top plate, the side plate is arranged tilted downward, and an aeration chamber is formed between the material guide hood and the bottom of the metering barrel under the action of the side plate, a hollow rotating platform is arranged at the bottom of the metering barrel, the metering barrel is rotatably arranged through the hollow rotating platform, a rotating joint is also arranged at the bottom of the metering barrel, the air outlet end of the rotating joint extends into the aeration chamber, aeration columns are arranged on the side plates, the aeration columns are evenly distributed on the side plates of the material guide hood, and aeration holes are arranged on the aeration columns.

[0007] Preferably, a powder toggle plate is also provided on the top of the material guide cover, and the powder toggle plate includes a rotating shaft mounted on the top of the material guide cover and a material distribution plate arranged on the top of the rotating shaft. A toggle rod is provided on the side wall of the material distribution plate, and the toggle rods are evenly distributed on the side wall of the material distribution plate. An outer gear ring is provided at the end of the toggle rod away from the material distribution plate, and the outer gear ring is mounted on the outer side of the material distribution plate. A driving rack is also provided on the filling seat, and the driving rack is arranged on the through hole wall of the filling seat, and a driving gear meshing with the driving rack is provided on the fixed seat. A rotating shaft is mounted in the middle part of the driving gear, and a transmission gear is mounted on the other end of the rotating shaft, and the transmission gear is meshed with a connecting gear, and the connecting gear is mounted on a connecting shaft, and a meshing gear is mounted on the end of the connecting shaft away from the connecting gear, and the meshing gear is meshed with the outer gear ring, and the driving rack controls the rotation of the driving gear through the lifting and lowering of the filling seat, thereby driving the outer gear ring to rotate reciprocatingly.

[0008] Preferably, a material-moving column is provided at the bottom of the moving rod.

[0009] Preferably, a support column is further provided on the side plate, a support ball is provided on the top of the support column, an annular groove is provided on the bottom of the outer gear ring, and the support ball is seated in the annular groove.

[0010] Preferably, the powder feeding device comprises a powder hopper and a feeding pipe arranged at the bottom of the powder hopper, and an auger feeding rod is mounted inside the feeding pipe and the powder hopper, and the auger feeding rod is rotatably arranged inside the feeding pipe and the powder hopper.

[0011] Preferably, a driving rod is provided at the top of the auger discharge rod, a stirring tube is sheathed on the driving rod, a stirring rod is sheathed on the stirring tube, a bearing is sheathed between the stirring tube and the driving rod, and the stirring tube is rotatably arranged in the powder hopper.

[0012] Preferably, the stirring tube and the driving rod rotate at different speeds.

[0013] Compared with the prior art, the advantages and positive effects of the present invention are:

[0014] 1. The present invention provides an automatic feeding system for the production of glyceryl phosphoryl choline capsules. By improving the structures of a powder feeding device and a metering and filling device on the basis of an existing automatic capsule filling machine, the purpose of drying and dispersing the glyceryl phosphoryl choline material can be achieved, thereby avoiding the problem of hardening caused by its hygroscopic characteristics and affecting the filling effect. At the same time, the automatic feeding system for the production of glyceryl phosphoryl choline capsules provided by the present invention mainly relies on the existing power structure to achieve dual-function output, with low transformation cost and suitable for large-scale promotion and use. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0016] Figure 1 A schematic diagram of the structure of the automatic feeding system for producing glycerol phosphorylcholine capsules provided in Example 1;

[0017] Figure 2 A front view of the automatic feeding system for producing glyceryl phosphorylcholine capsules provided in Example 1;

[0018] Figure 3 A front view of the automatic feeding system for producing glycerol phosphorylcholine capsules provided in Example 1 in a partially cut-away state;

[0019] Figure 4 A schematic diagram of the structure of the metering and filling device provided in Example 1 in a partially cut-away state;

[0020] Figure 5 A top view of the metering barrel provided in Example 1;

[0021] Figure 6 A schematic diagram of the structure of the driving mechanism of the powder material shifting disk provided in Example 1;

[0022] In the above figures, 1, metering barrel; 11, metering hole; 12, material guide cover; 121, top plate; 1211, rotating tube; 122, side plate; 123, aeration column; 13, aeration chamber; 14, support column; 15, support ball; 2, filling seat; 21, filling rod; 22, driving rack; 3, fixed seat; 31, lifting cylinder; 32, driving gear; 33, driving seat; 34, rotating shaft; 35, transmission gear; 36. Connecting gear; 37. Connecting shaft; 38. Meshing gear; 4. Powder toggle plate; 41. Rotating shaft; 42. Distributing plate; 43. Toggle rod; 44. Outer gear ring; 45. Distributing column; 5. Powder hopper; 51. Feeding pipe; 6. Auger feeding rod; 61. Driving rod; 62. Auger driving motor; 7. Stirring tube; 71. Stirring rod; 72. Stirring driving motor; 8. Hollow rotating platform; 9. Rotating joint. DETAILED DESCRIPTION

[0023] In order to more clearly understand the above-mentioned purpose, features and advantages of the present invention, the present invention is further described below in conjunction with the accompanying drawings and embodiments. It should be noted that the embodiments of the present application and the features in the embodiments can be combined with each other without conflict.

[0024] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways than those described herein. Therefore, the present invention is not limited to the specific embodiments of the following disclosure.

[0025] Embodiment 1, as Figure 1 to Figure 6 As shown, the present embodiment aims to improve the existing automatic filling machine for plug-type capsules so that it can meet the needs of filling glyceryl phosphoryl choline capsules. To this end, the present embodiment provides an automatic feeding system for producing glyceryl phosphoryl choline capsules, including a powder feeding device and a metering and filling device arranged below the powder feeding device, wherein the metering and filling device includes a rotatable metering barrel 1 and a filling seat 2 arranged above the metering barrel 1, a filling rod 21 is arranged on the filling seat 2, a metering hole 11 matched with the filling rod 21 is arranged at the bottom of the metering barrel 1, a fixed seat 3 is further arranged between the filling seat 2 and the metering barrel 1, the filling seat 2 is lifted and arranged above the fixed seat 3, and the middle parts of the filling seat 2 and the fixed seat 3 are both provided with through holes for feeding.

[0026] Like the existing design, the filling seat 2 is set above the fixed seat 3 by the lifting cylinder 31, and the fixed ends of the fixed seat 3 and the lifting cylinder 31 are fixed by bolts. Since this embodiment is aimed at the automatic filling machine of plug-in capsules, it mainly presses the divided materials in the metering barrel 1 into the metering hole 11 through different filling rods 21 to finally complete the filling of the capsule. For this purpose, the metering barrel 1 needs to be rotated, and the rotating metering hole 11 is under different filling rods 21, and the filling rods 21 need to be lifted and lowered to complete the pressing of the powder into the metering hole 11. The above structure is a common structure of the metering and filling device in the existing automatic filling machine of plug-in capsules, so it is not described in detail in this embodiment.

[0027] Considering that humidity is unavoidable in the operating environment of the automatic filling machine for plug-type capsules, it is necessary to dehumidify the glycerol phosphoryl choline. To this end, in the present embodiment, a material guide cover 12 is provided at the bottom of the metering barrel 1. The material guide cover 12 includes a top plate 121 and a side plate 122 arranged on the edge of the top plate 121. In the present embodiment, the pressing stage of the filling rod 21 is divided into six stages. To this end, the top plate 121 is arranged in a hexagonal shape, and the side plate 122 is arranged in a trapezoidal shape. Each side plate 122 corresponds to a group of filling rods 21.

[0028] In order to enable glycerolphosphorylcholine to effectively flow into the metering hole 11, the side plate 122 is tilted downward. At the same time, an aeration chamber 13 is formed between the material guide cover 12 and the bottom of the metering barrel 1 under the action of the side plate 122. In the present embodiment, in order to facilitate installation, a hole is opened at the bottom of the metering barrel 1. At the same time, a sealing disk is used to fix it with bolts. A hollow rotating platform 8 is provided at the bottom of the metering barrel 1. The purpose of setting the hollow rotating platform 8 is mainly to expose the center of the metering barrel 1 for convenient ventilation. The metering barrel 1 is rotatably arranged through the hollow rotating platform 8. At the same time, a rotating joint 9 is also provided at the bottom of the metering barrel 1. The air outlet end of the rotating joint 9 extends into the aeration chamber 13. An aeration column 123 is provided on the side plate 122. The aeration columns 123 are evenly distributed on the side plate 122 of the material guide cover 12, and aeration holes are provided on the aeration columns 123. In this way, the ventilation has two functions. One is to break up the glycerol phosphorylcholine powder that is stuck together, and the other purpose is to reduce the humidity in the metering barrel 1 by introducing hot air at a certain temperature, thereby achieving the purpose of dehumidification.

[0029] Considering that the air pressure of aeration is not easy to be too high, some sticky powders may not be able to be broken up by air. For this reason, a powder shaking plate 4 is also provided on the top of the material guide cover 12. The powder shaking plate 4 includes a rotating shaft 41 mounted on the top of the material guide cover 12 and a material distribution plate 42 arranged on the top of the rotating shaft 41. Considering that there is a certain thickness of powder in the metering barrel 1 and the metering barrel 1 is in a rotating state, a driving mechanism of the powder shaking plate 4 is required. In order to avoid interference between the driving mechanism of the powder shaking plate 4 and the rotation of the metering barrel 1, in this embodiment, a rotating tube 1211 is provided on the top of the top plate 121, and the rotating shaft 41 is mounted in the rotating tube 1211 through a bearing. In this way, if the powder shaking plate 4 is fixed, the rotation of the metering barrel 1 will not cause interference.

[0030] In order to achieve the purpose of stirring the glycerol phosphorylcholine in the metering barrel 1, in the present embodiment, a toggle rod 43 is provided on the side wall of the distribution disk 42. In the present embodiment, 6 evenly distributed toggle rods 43 are provided on the side wall of the distribution disk 42, and an outer gear ring 44 is provided at one end of the toggle rod 43 away from the distribution disk 42, and the outer gear ring 44 is mounted on the outer side of the distribution disk 42.

[0031] Considering that the filling seat 2 needs to be lifted and lowered, and lifting requires power, in order to reduce the cost of modification as much as possible, in the present embodiment, a driving rack 22 is further provided on the filling seat 2, and the driving rack 22 is arranged on the through-hole wall of the filling seat 2. Considering that the fixed seat 3 is in a stationary state and the metering barrel 1 is in a rotating state, it is necessary to place the driving mechanism on the fixed seat 3. For this reason, a driving gear 32 meshing with the driving rack 22 is provided on the fixed seat 3. At the same time, a driving seat 33 is provided on the fixed seat 3. The driving seat 33 is U-shaped, and its main purpose is to install the bearing. A rotating shaft 34 is provided in the middle of the driving gear 32, and both ends of the rotating shaft 34 pass through A bearing is arranged. At the same time, a transmission gear 35 is installed at the other end of the rotating shaft 34. The transmission gear 35 is a bevel gear. The transmission gear 35 is meshed with a connecting gear 36. The connecting gear 36 is also a bevel gear. The connecting gear 36 is installed with a connecting shaft 37. The connecting shaft 37 is equipped with a bearing outside. The bearing is installed on the fixed seat 3. A meshing gear 38 is installed at the end of the connecting shaft 37 away from the connecting gear 36. The meshing gear 38 is meshed with the outer gear ring 44. In order to ensure the stability of the meshing gear 38, a stabilizing tube can be arranged at the bottom of the fixed seat 3. The connecting shaft 37 is arranged through the stabilizing tube. A bearing is also arranged in the stabilizing tube to ensure the stability of the rotation of the connecting shaft 37.

[0032] In this way, during the lifting process of the filling seat 2, the driving rack 22 is driven to lift, and the driving rack 22 drives the driving gear 32 to rotate, thereby driving the transmission gear 35 to rotate, and the rotation of the transmission gear 35 drives the connecting gear 36 and the meshing gear 38 to rotate, and the rotation of the meshing gear 38 drives the outer gear ring 44 to rotate, thereby realizing the reciprocating swing of the powder tossing plate 4. In order to ensure the tossing effect on the glycerylphosphorylcholine, a tossing column 45 is provided at the bottom of the tossing rod 43. The tossing column 45 is arranged at intervals on the tossing rod 43, which makes the tossing column 45 in the gap between the aeration columns 123, so that it can also cooperate with the aeration column 123 for double crushing.

[0033] In order to ensure the stability of the powder material moving disk 4, in this embodiment, a support column 14 is further provided on the side plate 122, a support ball 15 is provided on the top of the support column 14, and an annular groove is provided at the bottom of the outer gear ring 44, and the support ball 15 is pressed in the annular groove. In this way, the stability of the powder material moving disk 4 is ensured without affecting the rotation of the two.

[0034] Considering that most of the glycerol phosphoryl choline is in the powder feeding device, in order to ensure the crushing effect at the source, in this embodiment, the powder feeding device includes a powder hopper 5 and a feeding pipe 51 arranged at the bottom of the powder hopper 5, and the feeding pipe 51 and the powder hopper 5 are provided with an auger feeding rod 6, and the auger feeding rod 6 is rotatably provided in the feeding pipe 51 and the powder hopper 5. At the same time, a driving rod 61 is provided at the top of the auger feeding rod 6, and a stirring tube 7 is provided outside the driving rod 61, and a stirring rod 71 is provided outside the stirring tube 7. A bearing is provided between the stirring tube 7 and the driving rod 61, and the stirring tube 7 is rotatably provided in the powder hopper 5. In this embodiment, different motors are used under the auger to realize the different speed rotation between the stirring tube 7 and the driving rod 61. Further improve the crushing effect, at the same time, the auger feeding rod 6 also has the purpose of controlling the feeding amount to ensure the stability of the operation of the entire system.

[0035] Through the above arrangement, the problem of moisture absorption of glycerol phosphorylcholine during the filling process is effectively solved, ensuring the normal operation of the automatic filling machine for plug-type capsules.

[0036] The above description is only a preferred embodiment of the present invention and does not limit the present invention in other forms. Any technician familiar with the profession may use the technical content disclosed above to change or modify it into an equivalent embodiment with equivalent changes and apply it to other fields. However, any simple modification, equivalent change and modification made to the above embodiment based on the technical essence of the present invention without departing from the content of the technical solution of the present invention still falls within the protection scope of the technical solution of the present invention.

Claims

1. An automatic feeding system for producing glycerol phosphorylcholine capsules, comprising a powder feeding device and a metering filling device arranged below the powder feeding device, wherein: The metering and filling device comprises a rotatable metering barrel and a filling seat arranged above the metering barrel, the filling seat is provided with a filling rod, the bottom of the metering barrel is provided with a metering hole matching the filling rod, a fixed seat is also provided between the filling seat and the metering barrel, the filling seat is lifted and arranged above the fixed seat, and the middle parts of the filling seat and the fixed seat are both provided with through holes for unloading materials, and the characteristic is that a material guide cover is provided at the bottom of the metering barrel, the material guide cover comprises a top plate and a side plate arranged at the edge of the top plate, the side plate is inclined downward, and an aeration chamber is formed between the material guide cover and the bottom of the metering barrel under the action of the side plate, a hollow rotating platform is provided at the bottom of the metering barrel, the metering barrel is rotatably arranged through the hollow rotating platform, a rotating joint is also provided at the bottom of the metering barrel, the air outlet end of the rotating joint extends into the aeration chamber, aeration columns are provided on the side plates, the aeration columns are evenly distributed on the side plates of the material guide cover, and aeration holes are provided on the aeration columns.

2. The automatic feeding system for producing glycerol phosphorylcholine capsules according to claim 1, characterized in that: The top of the material guide cover is also provided with a powder toggle plate, and the powder toggle plate includes a rotating shaft mounted on the top of the material guide cover and a material distribution plate arranged on the top of the rotating shaft. A toggle rod is arranged on the side wall of the material distribution plate, and the toggle rod is evenly distributed on the side wall of the material distribution plate. An outer gear ring is arranged on the end of the toggle rod away from the material distribution plate, and the outer gear ring is mounted on the outer side of the material distribution plate. A driving rack is also arranged on the filling seat, and the driving rack is arranged on the through hole wall of the filling seat, and a driving gear meshing with the driving rack is arranged on the fixed seat. A rotating shaft is mounted in the middle of the driving gear, and a transmission gear is mounted on the other end of the rotating shaft, and the transmission gear is meshed with a connecting gear, and the connecting gear is mounted on a connecting shaft, and a meshing gear is mounted on the end of the connecting shaft away from the connecting gear, and the meshing gear is meshed with the outer gear ring, and the driving rack controls the rotation of the driving gear through the lifting and lowering of the filling seat, thereby driving the outer gear ring to rotate reciprocatingly.

3. The automatic feeding system for producing glycerol phosphorylcholine capsules according to claim 2, characterized in that: A material-shifting column is arranged at the bottom of the shifting rod.

4. The automatic feeding system for producing glycerol phosphorylcholine capsules according to claim 3, characterized in that: The side plate is also provided with a support column, the top of the support column is provided with a support ball, the bottom of the outer gear ring is provided with an annular groove, and the support ball is placed in the annular groove.

5. The automatic feeding system for producing glycerol phosphorylcholine capsules according to any one of claims 1 to 4, characterized in that: The powder feeding device comprises a powder hopper and a feeding pipe arranged at the bottom of the powder hopper, wherein the feeding pipe and the powder hopper are provided with an auger feeding rod, and the auger feeding rod is rotatably arranged in the feeding pipe and the powder hopper.

6. The automatic feeding system for producing glycerol phosphorylcholine capsules according to claim 5, characterized in that: A driving rod is arranged on the top of the auger feeding rod, a stirring tube is sheathed on the driving rod, a stirring rod is sheathed on the stirring tube, a bearing is sheathed between the stirring tube and the driving rod, and the stirring tube is rotatably arranged in the powder hopper.

7. The automatic feeding system for producing glycerol phosphorylcholine capsules according to claim 6, characterized in that: The stirring tube and the driving rod rotate at different speeds.

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