Flow type antibody microsphere packaging structure

Abstract

The invention discloses a flow type antibody microsphere packaging structure which comprises a pipe body, antibody microspheres arranged at the bottom of the pipe body and a cover body used for sealing the pipe body, the bottom of the cover body extends towards the bottom of the pipe body to be provided with a hollow limiting part used for limiting the antibody microspheres, and the hollow limiting part is connected with the bottom of the cover body through a rod body. According to the invention, not only can the antibody microspheres be effectively fixed and prevented from displacement, but also the safety and the reliability of storage are improved through diversified limiting design and monitoring means, and the method has a wide application prospect.

Description

Technical Field

[0001] The invention belongs to the technical field of flow tubes and discloses a flow antibody microsphere packaging structure. Background Art

[0002] As an important biomaterial, antibody microspheres have a wide range of applications in drug delivery, immunoassays, and biosensors. Due to their tiny size (usually between 1 μm and 250 μm), antibody microspheres have a large specific surface area, which can effectively improve the bioavailability and targeting of drugs. However, antibody microspheres face many challenges in storage and transportation in practical applications, especially in storage devices such as flow tubes, where their small size and high flexibility make fixation and stabilization particularly difficult.

[0003] At present, many traditional antibody microsphere storage methods use a bottom iron sheet or similar structure to fix the microspheres. Although this fixation method is simple, it has several obvious defects. First, the material of the iron sheet may react with the antibody microspheres, resulting in reduced activity and affecting subsequent experimental results. Secondly, the bottom iron sheet cannot completely prevent the displacement of the microspheres in the flow tube, and the random movement of the microspheres may lead to inconsistency and poor repeatability of the experimental data. In addition, traditional fixing structures often increase the complexity of assembly and disassembly, which is not convenient for experimental operation and maintenance. Summary of the invention

[0004] To solve the above problems, the present invention provides a flow cytometry antibody microsphere packaging structure, which can effectively fix the antibody microspheres and prevent them from displacement, while improving the safety and reliability of storage through a variety of limit designs and monitoring methods.

[0005] The technical solution provided by the present invention is as follows:

[0006] A flow-type antibody microsphere packaging structure comprises a tube body, antibody microspheres disposed at the bottom of the tube body, and a cover body for sealing the tube body. The bottom of the cover body is provided with a hollow limiting portion for limiting the antibody microspheres extending toward the bottom of the tube body, and the hollow limiting portion is connected to the bottom of the cover body through a rod body.

[0007] In some embodiments, the tube body is a flow tube or a glass tube.

[0008] In some embodiments, the hollow limiting portion is claw-shaped, and the ends of the plurality of claws wrap and fix the antibody microspheres.

[0009] In some embodiments, the hollow limiting portion is a mesh cover type, and the mesh cover type cover covers and fixes the antibody microspheres.

[0010] In some embodiments, a protrusion is provided in the middle of the rod body, and the outer periphery of the protrusion is in contact with the inner wall of the tube body.

[0011] In some embodiments, a layer of hygroscopic sheet is disposed on the periphery of the protrusion, and water-absorbing color-developing lines are formed on the hygroscopic sheet.

[0012] In some embodiments, the cap is a threaded cap or a plug.

[0013] In some embodiments, the stopper body is a rubber stopper or a wooden stopper.

[0014] In summary, the beneficial effects of the present invention are as follows:

[0015] (1) The present invention can not only effectively fix the antibody microspheres and prevent them from displacement, but also improve the safety and reliability of storage through a variety of limit designs and monitoring methods, and has broad application prospects.

[0016] (2) The protrusions of the present invention can further seal the storage chamber of the antibody microspheres to ensure dryness and prevent the antibody microspheres from getting wet.

[0017] (3) The hygroscopic sheet on the outer periphery of the protrusion of the present invention has a water absorption color line, which changes from yellow to blue according to the amount of water absorbed. Due to the moisture condition of the antibody microspheres in the detection tube body, the long-term stability of the antibody microspheres is ensured. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 This is a schematic diagram of the explosion structure of Example 1 of the present invention;

[0019] Figure 2 This is a schematic diagram of the internal structure of Embodiment 2 of the present invention;

[0020] Figure 3 This is a schematic diagram of the cross-sectional structure of Example 1 of the present invention;

[0021] Figure 4 This is a schematic diagram of the cross-sectional structure of Example 2 of the present invention.

[0022] The reference numerals are as follows:

[0023] 1. Tube body; 2. Antibody microspheres; 3. Cover body; 4. Hollow limiter; 5. Rod body; 6. Protrusion; 7. Moisture absorbent sheet. DETAILED DESCRIPTION

[0024] In order to deepen the understanding of the present invention, the present invention will be further described in detail below in conjunction with embodiments and drawings. The embodiments are only used to explain the present invention and do not constitute a limitation on the protection scope of the present invention.

[0025] Example 1

[0026] Please refer to Figure 1 , 3This embodiment provides a flow cytometry antibody microsphere packaging structure, including a tube body 1, a cover body 3, and antibody microspheres 2. First, the antibody microspheres 2 are placed at the bottom of the tube body 1. In order to ensure that the antibody microspheres 2 will not be displaced during transportation or storage, the cover body 3 is designed as a cover with a limited structure, so that the microspheres can be further fixed and the tube body 1 can be sealed.

[0027] The tube body 1 is a flow tube or a glass tube, and the material is mainly selected with high transparency to ensure that the experimenter can clearly observe the storage status of the antibody microspheres in the tube body. The main body of the tube body 1 is a hollow cylindrical structure as a whole, and the bottom of the tube body 1 is designed to be arc-shaped, which can better accommodate and support the microspheres and prevent the microspheres from gathering in a certain position due to the irregular shape of the bottom.

[0028] The cover 3 is designed to ensure sealing and stability. A rod 5 is provided at the bottom of the cover 3. The rod 5 is made of a strong and lightweight material to reduce the weight burden inside the tube body and ensure that the antibody microspheres 2 are not easily deformed or broken during the limiting process. The rod 5 extends to the bottom of the tube body 1. The end of the rod 5 is connected to the hollow limiting portion 4. The hollow limiting portion 4 in this embodiment is designed as a claw-type structure. The number of claws is designed to be eight. Each claw is evenly spaced and forms a stable encirclement around the antibody microspheres 2. The ends of the claws are curved to ensure that the antibody microspheres 2 are effectively wrapped and fixed. Even during severe shaking or transportation, the antibody microspheres 2 will not fall off or shift, and the microspheres will not move or deviate from the initial position due to external forces or movement of the tube body.

[0029] The cover 3 is sealed by cooperating with the thread on the top of the tube 1, and when tightened, the microspheres inside are protected from the influence of external air or moisture. This structure not only keeps the antibody microspheres 2 stable in the flow tube, but also simplifies the assembly and disassembly operations, making it easy for experimenters to use and replace them quickly.

[0030] Example 2

[0031] Please refer to Figure 2 , 4 This embodiment is formed on the basis of the embodiment 1, and the storage quality of the antibody microspheres 2 is improved by further setting the structure of the rod body 5. Specifically:

[0032] The hollow limiting portion 4 of this embodiment is designed as a mesh cover type, which is semicircular and covers the antibody microspheres 2. The mesh aperture is smaller than the diameter of the antibody microspheres 2, which can effectively cover the antibody microspheres 2 and prevent them from displacement in the tube.

[0033] In this embodiment, a cylindrical protrusion 6 is provided in the middle of the rod body 5, the outer periphery of the protrusion 6 is in contact with the inner wall of the tube body 1, and the space from the protrusion 6 to the bottom of the tube body 1 forms a storage chamber for the antibody microspheres 2, and the outer periphery of the protrusion 6 is in close contact with the inner wall of the tube body 1. This design isolates the chamber for storing the antibody microspheres 2 from the external environment to form an independent sealed environment, which greatly reduces the risk of damage to the performance of the antibody microspheres 2 due to changes in external humidity. Especially in an experimental environment with high humidity, the design of the protrusion 6 can effectively reduce the contact between the antibody microspheres and the external air, and keep the microspheres dry for a long time.

[0034] In this embodiment, a hygroscopic sheet 7 can also be provided on the periphery of the protrusion 6. The hygroscopic sheet 7 has a water absorption color line, which changes from yellow to blue according to the amount of water absorbed. Due to the moisture condition of the antibody microspheres 2 in the detection tube body 1, the long-term stability of the antibody microspheres 2 is ensured. If the hygroscopic sheet 7 changes color obviously, it means that the antibody microspheres 2 have been damp and cannot be used again. The other side of the hygroscopic sheet 7 can be used as an information identification carrier to paste product-related information, including the type, production batch, and expiration date of the antibody microspheres 2, so that the experimenter can quickly identify the product information when using it to avoid misuse or expired use.

[0035] The flow cytometry antibody microsphere 2 packaging structure of the present application can not only effectively fix the antibody microsphere 2 to prevent its displacement, but also improve the safety and reliability of storage through a variety of limit designs and monitoring methods.

[0036] It should be noted that the implementation methods not shown or described in the drawings or the text of the specification are all forms known to ordinary technicians in the relevant technical field and are not described in detail. In addition, the above definitions of each element and method are not limited to the various specific structures, shapes or methods mentioned in the embodiments.

[0037] It should also be noted that this document may provide demonstrations of parameters containing specific values, but these parameters do not need to be exactly equal to the corresponding values, but can be approximated to the corresponding values ​​within an acceptable error tolerance or design constraint. Directional terms mentioned in the embodiments, such as "upper", "lower", "front", "back", "left", "right", "inner", "outer", etc., are only referenced to the directions of the drawings and are not intended to limit the scope of protection of this application.

[0038] The above description shows and describes the preferred embodiments of the present invention. As mentioned above, it should be understood that the present invention is not limited to the form disclosed herein, and should not be regarded as excluding other embodiments, but can be used in various other combinations, modifications and environments, and can be modified within the scope of the invention concept described herein through the above teachings or the technology or knowledge of the relevant field. Changes and variations made by those skilled in the art do not depart from the spirit and scope of the present invention, and should be within the scope of protection of the claims attached to the present invention.

Claims

1. A flow cytometry antibody microsphere packaging structure, characterized in that: The invention comprises a tube body (1), an antibody microsphere (2) disposed at the bottom of the tube body (1), and a cover body (3) used for sealing the tube body (1); the bottom of the cover body (3) is provided with a hollow limiting portion (4) extending toward the bottom of the tube body (1) and used for limiting the position of the antibody microsphere (2); the hollow limiting portion is connected to the bottom of the cover body (3) via a rod body (5).

2. The flow cytometry antibody microsphere packaging structure according to claim 1, characterized in that: The tube body (1) is a flow tube or a glass tube.

3. The flow cytometry antibody microsphere packaging structure according to claim 1, characterized in that: The hollow limiting portion (4) is claw-shaped, and the ends of a plurality of claws wrap and fix the antibody microspheres (2).

4. The flow cytometry antibody microsphere packaging structure according to claim 1, characterized in that: The hollow limiting portion (4) is of a mesh cover type, and the mesh cover type cover covers and fixes the antibody microspheres (2).

5. The flow cytometry antibody microsphere packaging structure according to claim 1, characterized in that: A protrusion (6) is provided in the middle of the rod body (5), and the outer periphery of the protrusion (6) is in contact with the inner wall of the tube body (1).

6. The flow cytometry antibody microsphere packaging structure according to claim 5, characterized in that: A layer of moisture-absorbing sheet (7) is arranged on the outer periphery of the protrusion (6), and the moisture-absorbing sheet (7) has water-absorbing color-developing lines.

7. The flow cytometry antibody microsphere packaging structure according to claim 1, characterized in that: The cover body (3) is a threaded cover or a plug body.

8. The flow cytometry antibody microsphere packaging structure according to claim 1, characterized in that: The plug body is a rubber plug or a wooden plug.

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