Cardiac angiography imaging method and ultrasonic imaging equipment

Abstract

The invention provides a myocardial angiography imaging method and ultrasonic imaging equipment. The method comprises the following steps: acquiring multiple frames of ultrasonic images of the heart of a target object in a myocardial perfusion process; acquiring an electrocardiosignal of the target object in the myocardial perfusion process; identifying the position of the heart time phase in the electrocardiosignal; taking the ultrasonic image corresponding to the heart time phase as a key frame image of the heart time phase; generating an electrocardiogram pattern representing the electrocardiosignal; at least marking the position of the first heart time phase in the electrocardiosignal on the electrocardiogram form; detecting whether a reset operation of the user on the first heart time phase is received or not, if the reset operation is received, setting the position of the first heart time phase in the electrocardiosignal, re-determining the key frame image, and if the reset operation is not received, keeping the key frame image unchanged. According to the myocardial angiography imaging method and the ultrasonic imaging equipment, the user is allowed to manually adjust the position of the heart time phase, so that the heart time phase more conforming to the expectation of the user can be obtained.

Description

Technical Field

[0001] The present invention relates to the technical field of ultrasonic imaging, and in particular to a myocardial contrast imaging method and an ultrasonic imaging device. Background Art

[0002] For biological tissues such as the myocardium of the heart, it is very important to objectively and quantitatively evaluate its function in the diagnosis of the biological tissue. Quantitative analysis of the myocardium includes: during the perfusion of the contrast agent into the heart of the target object, the ultrasound device emits ultrasonic waves, generates ultrasonic images based on the echo signals of the ultrasonic waves, and quantitatively analyzes the myocardium based on the acquired ultrasonic images. In particular, during the perfusion process, ultrasonic waves are emitted to the heart to break up the contrast microbubbles in the myocardium. After the contrast microbubbles in the myocardium are broken up, the ultrasonic images collected during the reperfusion of the contrast agent are used to quantitatively analyze the myocardium.

[0003] In the above methods, attention is often paid to ultrasound images at certain specific moments. For example, medical staff will focus on ultrasound images at the end of diastole, end of systole and other phases. Therefore, when performing quantitative analysis on the myocardium, how to more accurately obtain the ultrasound images corresponding to each time is one of the problems that need to be improved or solved. Summary of the invention

[0004] According to a first aspect, an embodiment of the present application provides an ultrasonic imaging device, comprising:

[0005] monitor;

[0006] Ultrasound probe;

[0007] A transmitting circuit, used for stimulating the ultrasonic probe to transmit ultrasonic waves toward a target object;

[0008] A receiving circuit, used for controlling the ultrasonic probe to receive the ultrasonic echo to obtain the ultrasonic echo signal;

[0009] Processor for:

[0010] controlling the ultrasound probe to transmit ultrasound waves to the heart of the target object during myocardial perfusion of the target object;

[0011] generating a multi-frame ultrasound image of the target object during myocardial perfusion according to the ultrasound echo signal returned by the heart;

[0012] Acquiring an electrocardiogram signal of a target object during myocardial perfusion, wherein each frame of the ultrasound image generated during the myocardial perfusion of the target object has a corresponding relationship with the electrocardiogram signal at at least one moment;

[0013] Identify the position of a cardiac phase in the electrocardiogram signal during myocardial perfusion of the target object, wherein the position of the cardiac phase in the electrocardiogram signal represents the time when the cardiac phase occurs;

[0014] Based on the correspondence between each frame of the ultrasound image and at least one electrocardiographic signal at a time, taking the ultrasound image corresponding to the cardiac phase as a key frame image of the cardiac phase;

[0015] generating an electrocardiogram representing the electrocardiogram according to the electrocardiogram signal;

[0016] Controlling the display to display the electrocardiogram, at least marking the position of a first cardiac phase in the electrocardiogram on the electrocardiogram, wherein the first cardiac phase is any one of the cardiac phases;

[0017] Detect whether a reset operation for the first cardiac phase by the user is received; if the reset operation is received, reset the position of the first cardiac phase in the electrocardiogram signal according to the reset operation, and use the ultrasound image corresponding to the first cardiac phase after the reset position as the key frame image of the first cardiac phase; if the reset operation is not received, keep the key frame image of the first cardiac phase unchanged.

[0018] According to a second aspect, an embodiment of the present application provides an ultrasonic imaging device, comprising:

[0019] monitor;

[0020] Ultrasound probe;

[0021] A transmitting circuit, used for stimulating the ultrasonic probe to transmit ultrasonic waves to a target object;

[0022] A receiving circuit, used for controlling the ultrasonic probe to receive the ultrasonic echo to obtain the ultrasonic echo signal;

[0023] Processor for:

[0024] controlling the ultrasound probe to transmit ultrasound waves to the heart of the target object during myocardial perfusion of the target object;

[0025] generating a multi-frame ultrasound image of the target object during myocardial perfusion according to the ultrasound echo signal returned by the heart;

[0026] Acquiring an electrocardiogram signal of a target object during myocardial perfusion, wherein each frame of the ultrasound image generated during the myocardial perfusion of the target object has a corresponding relationship with the electrocardiogram signal at at least one moment;

[0027] Identify the position of a cardiac phase in the electrocardiogram signal during myocardial perfusion of the target object, wherein the position of the cardiac phase in the electrocardiogram signal represents the time when the cardiac phase occurs;

[0028] Based on the correspondence between each frame of the ultrasound image and at least one electrocardiographic signal at a time, taking the ultrasound image corresponding to the cardiac phase as a key frame image of the cardiac phase;

[0029] generating an electrocardiogram representing the electrocardiogram according to the electrocardiogram signal;

[0030] Controlling the display to display the electrocardiogram;

[0031] Controlling the display to display a phase confirmation control, wherein the phase confirmation control is used to trigger a reset instruction corresponding to any cardiac phase based on a user's operation, wherein the reset instruction is used to reset the position of the corresponding cardiac phase in the electrocardiogram signal;

[0032] It is detected whether the reset instruction corresponding to any heart phase is triggered. If the reset instruction is triggered, the ultrasound image corresponding to the heart phase after the position is reset is used as the key frame image of the heart phase.

[0033] According to a third aspect, an embodiment of the present application provides an ultrasonic imaging device, comprising:

[0034] monitor;

[0035] Ultrasound probe;

[0036] A transmitting circuit, used for stimulating the ultrasonic probe to transmit ultrasonic waves to a target object;

[0037] A receiving circuit, used for controlling the ultrasonic probe to receive the ultrasonic echo to obtain the ultrasonic echo signal;

[0038] Processor for:

[0039] controlling the ultrasound probe to transmit ultrasound waves to the heart of the target object during myocardial perfusion of the target object;

[0040] generating a multi-frame ultrasound image of the target object during myocardial perfusion according to the ultrasound echo signal returned by the heart;

[0041] Acquiring an electrocardiogram signal of a target object during myocardial perfusion, wherein each frame of the ultrasound image generated during the myocardial perfusion of the target object has a corresponding relationship with the electrocardiogram signal at at least one moment;

[0042] generating an electrocardiogram representing the electrocardiogram according to the electrocardiogram signal;

[0043] Controlling the display to display the electrocardiogram;

[0044] Detecting a setting operation of a cardiac phase input by a user for the electrocardiogram, and setting a position of a cardiac phase during myocardial perfusion of the target object in the electrocardiogram based on the setting operation, wherein the position of the cardiac phase in the electrocardiogram represents a time when the cardiac phase occurs;

[0045] Based on the correspondence between each frame of the ultrasonic image and the electrocardiographic signal at at least one moment, the ultrasonic image corresponding to the cardiac phase is used as a key frame image of the cardiac phase.

[0046] According to a fourth aspect, an embodiment of the present application provides a myocardial contrast imaging method, comprising:

[0047] transmitting ultrasound waves to the heart of the target subject during myocardial perfusion of the target subject;

[0048] generating a multi-frame ultrasound image of the target object during myocardial perfusion according to the ultrasound echo signal returned by the heart;

[0049] Acquiring an electrocardiogram signal of a target object during myocardial perfusion, wherein each frame of the ultrasound image generated during the myocardial perfusion of the target object has a corresponding relationship with the electrocardiogram signal at at least one moment;

[0050] Identify the position of a cardiac phase in the electrocardiogram signal during myocardial perfusion of the target object, wherein the position of the cardiac phase in the electrocardiogram signal represents the time when the cardiac phase occurs;

[0051] Based on the correspondence between each frame of the ultrasound image and at least one electrocardiographic signal at a time, taking the ultrasound image corresponding to the cardiac phase as a key frame image of the cardiac phase;

[0052] generating an electrocardiogram representing the electrocardiogram according to the electrocardiogram signal;

[0053] Display the electrocardiogram, and at least mark the position of the first cardiac phase in the electrocardiogram on the electrocardiogram, wherein the first cardiac phase is any one of the cardiac phases;

[0054] Detect whether a reset operation for the first cardiac phase by the user is received; if the reset operation is received, reset the position of the first cardiac phase in the electrocardiogram signal according to the reset operation, and use the ultrasound image corresponding to the first cardiac phase after the reset position as the key frame image of the first cardiac phase; if the reset operation is not received, keep the key frame image of the first cardiac phase unchanged.

[0055] According to the fifth aspect, an embodiment of the present application provides a myocardial contrast imaging method, comprising:

[0056] transmitting ultrasound waves to the heart of the target subject during myocardial perfusion of the target subject;

[0057] generating a multi-frame ultrasound image of the target object during myocardial perfusion according to the ultrasound echo signal returned by the heart;

[0058] Acquiring an electrocardiogram signal of a target object during myocardial perfusion, wherein each frame of the ultrasound image generated during the myocardial perfusion of the target object has a corresponding relationship with the electrocardiogram signal at at least one moment;

[0059] generating an electrocardiogram representing the electrocardiogram according to the electrocardiogram signal;

[0060] Displaying the electrocardiogram;

[0061] Displaying a phase confirmation control, wherein the phase confirmation control is used to trigger a corresponding reset instruction for any cardiac phase based on a user's operation, wherein the reset instruction is used to reset the position of the corresponding cardiac phase in the electrocardiogram signal;

[0062] It is detected whether the reset instruction corresponding to any heart phase is triggered. If the reset instruction is triggered, the ultrasound image corresponding to the heart phase after the position is reset is used as the key frame image of the heart phase.

[0063] According to the sixth aspect, an embodiment of the present application provides a myocardial contrast imaging method, comprising:

[0064] transmitting ultrasound waves to the heart of the target subject during myocardial perfusion of the target subject;

[0065] generating a multi-frame ultrasound image of the target object during myocardial perfusion according to the ultrasound echo signal returned by the heart;

[0066] Acquiring an electrocardiogram signal of a target object during myocardial perfusion, wherein each frame of the ultrasound image generated during the myocardial perfusion of the target object has a corresponding relationship with the electrocardiogram signal at at least one moment;

[0067] generating an electrocardiogram representing the electrocardiogram according to the electrocardiogram signal;

[0068] Displaying the electrocardiogram;

[0069] Detecting a setting operation of a cardiac phase input by a user for the electrocardiogram, and setting a position of a cardiac phase during myocardial perfusion of the target object in the electrocardiogram based on the setting operation, wherein the position of the cardiac phase in the electrocardiogram represents a time when the cardiac phase occurs;

[0070] Based on the correspondence between each frame of the ultrasonic image and the electrocardiographic signal at at least one moment, the ultrasonic image corresponding to the cardiac phase is used as a key frame image of the cardiac phase.

[0071] According to the seventh aspect, an embodiment of the present application provides a myocardial angiography method, comprising:

[0072] Acquire multiple frames of ultrasound images of the heart of the target object during myocardial perfusion;

[0073] Acquiring an electrocardiogram signal of a target object during myocardial perfusion, wherein each frame of the ultrasound image generated during the myocardial perfusion of the target object has a corresponding relationship with the electrocardiogram signal at at least one moment;

[0074] Identify the position of a cardiac phase in the electrocardiogram signal during myocardial perfusion of the target object, wherein the position of the cardiac phase in the electrocardiogram signal represents the time when the cardiac phase occurs;

[0075] Based on the correspondence between each frame of the ultrasound image and at least one electrocardiographic signal at a time, taking the ultrasound image corresponding to the cardiac phase as a key frame image of the cardiac phase;

[0076] generating an electrocardiogram representing the electrocardiogram according to the electrocardiogram signal;

[0077] Display the electrocardiogram, and at least mark the position of the first cardiac phase in the electrocardiogram on the electrocardiogram, wherein the first cardiac phase is any one of the cardiac phases;

[0078] Detect whether a reset operation for the first cardiac phase by the user is received; if the reset operation is received, reset the position of the first cardiac phase in the electrocardiogram signal according to the reset operation, and use the ultrasound image corresponding to the first cardiac phase after the reset position as the key frame image of the first cardiac phase; if the reset operation is not received, keep the key frame image of the first cardiac phase unchanged.

[0079] According to the eighth aspect, an embodiment of the present application provides a myocardial angiography method, comprising:

[0080] Acquire multiple frames of ultrasound images of the heart of the target object during myocardial perfusion;

[0081] Acquiring an electrocardiogram signal of a target object during myocardial perfusion, wherein each frame of the ultrasound image generated during the myocardial perfusion of the target object has a corresponding relationship with the electrocardiogram signal at at least one moment;

[0082] Identify the position of a cardiac phase in the electrocardiogram signal during myocardial perfusion of the target object, wherein the position of the cardiac phase in the electrocardiogram signal represents the time when the cardiac phase occurs;

[0083] Based on the correspondence between each frame of the ultrasound image and at least one electrocardiographic signal at a time, taking the ultrasound image corresponding to the cardiac phase as a key frame image of the cardiac phase;

[0084] generating an electrocardiogram representing the electrocardiogram according to the electrocardiogram signal;

[0085] Displaying the electrocardiogram;

[0086] Displaying a phase confirmation control, wherein the phase confirmation control is used to trigger a corresponding reset instruction for any cardiac phase based on a user's operation, wherein the reset instruction is used to reset the position of the corresponding cardiac phase in the electrocardiogram signal;

[0087] It is detected whether the reset instruction corresponding to any heart phase is triggered. If the reset instruction is triggered, the ultrasound image corresponding to the heart phase after the position is reset is used as the key frame image of the heart phase.

[0088] According to the ninth aspect, an embodiment of the present application provides a myocardial angiography method, comprising:

[0089] Acquire multiple frames of ultrasound images of the heart of the target object during myocardial perfusion;

[0090] Acquiring an electrocardiogram signal of a target object during myocardial perfusion, wherein each frame of the ultrasound image generated during the myocardial perfusion of the target object has a corresponding relationship with the electrocardiogram signal at at least one moment;

[0091] generating an electrocardiogram representing the electrocardiogram according to the electrocardiogram signal;

[0092] Displaying the electrocardiogram;

[0093] Detecting a setting operation of a cardiac phase input by a user for the electrocardiogram, and setting a position of a cardiac phase during myocardial perfusion of the target object in the electrocardiogram based on the setting operation, wherein the position of the cardiac phase in the electrocardiogram represents a time when the cardiac phase occurs;

[0094] Based on the correspondence between each frame of the ultrasonic image and the electrocardiographic signal at at least one moment, the ultrasonic image corresponding to the cardiac phase is used as a key frame image of the cardiac phase.

[0095] According to the tenth aspect, an embodiment of the present application provides a medical device, including:

[0096] Memory, used to store programs;

[0097] A processor is used to implement the method as claimed in claim 1 by executing the program stored in the memory.

[0098] According to the eleventh aspect, an embodiment of the present application provides a computer-readable storage medium, on which a program is stored, and the program can be executed by a processor to implement the above method.

[0099] According to the myocardial contrast imaging method and ultrasonic imaging device of the above-mentioned embodiment, during the process of myocardial perfusion of the target object, both the electrocardiogram signal and multiple frames of ultrasonic images of the heart are obtained, each frame of the ultrasonic image has a corresponding relationship with the electrocardiogram signal at at least one moment, and the ultrasonic image corresponding to each cardiac phase is used as the key frame image of the cardiac phase. The ultrasonic imaging device first uses a preset algorithm to identify the position of the cardiac phase in the electrocardiogram, and then displays the position of the first cardiac phase in the electrocardiogram to the user by marking it on the electrocardiogram. The user can reset the position of the first cardiac phase in the electrocardiogram based on his own experience. After the position of the first cardiac phase in the electrocardiogram is reset, the key frame image corresponding to the first cardiac phase will also change accordingly.

[0100] Through the above-mentioned myocardial contrast imaging method and ultrasonic imaging equipment, on the one hand, the system can first automatically determine the cardiac phase and the key frame image of the cardiac phase, reducing the overall workload of the user; on the other hand, the recognition result of the cardiac phase is displayed to the user in a visual manner, and the user is allowed to manually adjust the position of the cardiac phase, so as to obtain a more accurate or more user-expected cardiac phase. BRIEF DESCRIPTION OF THE DRAWINGS

[0101] Figure 1 is a schematic structural diagram of an ultrasonic imaging device according to an embodiment;

[0102] Figure 2 A flowchart of a myocardial contrast imaging method according to an embodiment;

[0103] Figure 3 is a schematic diagram of a myocardial angiography imaging interface according to an embodiment;

[0104] Figure 4 A schematic diagram of a time phase synchronization setting interface of an embodiment

[0105] Figure 5 A flow chart of a myocardial contrast imaging method according to another embodiment;

[0106] Figure 6 A schematic diagram of a myocardial angiography imaging interface according to another embodiment;

[0107] Figure 7 A schematic diagram of a myocardial angiography imaging interface according to yet another embodiment;

[0108] Figure 8 A flowchart of a myocardial contrast imaging method according to another embodiment;

[0109] Fig. 9 The present invention is a flowchart of obtaining a region of interest in a transition frame image according to an embodiment. DETAILED DESCRIPTION

[0110] The present invention is further described in detail below by specific embodiments in conjunction with the accompanying drawings. Wherein similar elements in different embodiments adopt associated similar element numbers. In the following embodiments, many detailed descriptions are for making the present application better understood. However, those skilled in the art can easily recognize that some features can be omitted in different situations, or can be replaced by other elements, materials, methods. In some cases, some operations related to the present application are not shown or described in the specification, this is to avoid the core part of the present application being overwhelmed by too much description, and for those skilled in the art, it is not necessary to describe these related operations in detail, and they can fully understand the related operations according to the description in the specification and the general technical knowledge in the art.

[0111] In addition, the features, operations or characteristics described in the specification can be combined in any appropriate manner to form various implementations. At the same time, the steps or actions in the method description can also be interchanged or adjusted in a manner that is obvious to those skilled in the art. Therefore, the various sequences in the specification and the drawings are only for the purpose of clearly describing a certain embodiment and are not meant to be a required sequence, unless otherwise specified that a certain sequence must be followed.

[0112] The serial numbers of the components in this document, such as "first", "second", etc., are only used to distinguish the objects described and do not have any order or technical meaning. The "connection" and "coupling" mentioned in this application, unless otherwise specified, include direct and indirect connections (couplings).

[0113] The cardiac phases referred to in this application include but are not limited to the end-systolic phase (ES phase), the end-rapid filling phase (ERF phase) and the end-diastolic phase (ED phase). These phases have specific medical meanings in the electrocardiogram signal and are professional terms well known in the art.

[0114] The technical solution in the present application can be applied to any medical device with display, human-computer interaction and processing capabilities, including but not limited to monitors, central stations and ultrasonic imaging equipment. The hardware environment of the technical solution of the present application is introduced below using ultrasonic imaging equipment as an example.

[0115] like Figure 1 As shown, in some embodiments of the present application, an ultrasound imaging device 100 is disclosed, including an ultrasound probe 110, a transmitting circuit 112, a receiving circuit 114, a processor 116, and a display 118. Further, the ultrasound imaging device may also include a transmit / receive selection switch 120 and a beamforming module 122, and the transmit circuit 112 and the receiving circuit 114 may be connected to the ultrasound probe 110 through the transmit / receive selection switch 120.

[0116] The ultrasonic probe 110 includes a plurality of transducer array elements, which can be arranged in a row to form a linear array, or arranged in a two-dimensional matrix to form a surface array, or a plurality of transducer array elements can also form a convex array. The transducer array element is used to transmit ultrasonic waves according to the excitation electrical signal, or to convert the received ultrasonic waves into electrical signals, so each transducer array element can be used to realize the mutual conversion between the electrical pulse signal and the ultrasonic wave, so as to realize the transmission of ultrasonic waves to the tissue of the target area of ​​the object to be tested, and can also be used to receive the ultrasonic wave echo reflected by the tissue. When performing ultrasonic testing, which transducer array elements are used to transmit ultrasonic waves and which transducer array elements are used to receive ultrasonic waves can be controlled by the transmission sequence and the reception sequence, or the transducer array elements can be controlled to transmit ultrasonic waves or receive ultrasonic wave echoes in time slots. The transducer array elements participating in ultrasonic wave transmission can be excited by electrical signals at the same time, so as to transmit ultrasonic waves at the same time; or, the transducer array elements participating in ultrasonic wave beam transmission can also be excited by several electrical signals with a certain time interval, so as to continuously transmit ultrasonic waves with a certain time interval.

[0117] During the ultrasonic imaging process, the transmitting circuit 112 sends the delayed focused transmitting pulse to the ultrasonic probe 110 through the transmitting / receiving selection switch 120. The ultrasonic probe 110 is stimulated by the transmitting pulse to transmit an ultrasonic beam to the tissue of the target area of ​​the object to be measured, and receives the ultrasonic echo with tissue information reflected from the tissue of the target area after a certain delay, and reconverts the ultrasonic echo into an electrical signal. Among them, the object to be measured can be a person, or the object to be measured can also be an animal, such as a cat, a dog, a rabbit, etc. The receiving circuit 114 receives the electrical signal converted and generated by the ultrasonic probe 110, obtains the ultrasonic echo signal, and sends these ultrasonic echo signals to the beamforming module 122, and the beamforming module 122 performs focusing delay, weighting and channel summing on the ultrasonic echo data, and then sends it to the processor 116. The processor 116 performs signal detection, signal enhancement, data conversion, logarithmic compression and other processing on the ultrasonic echo signal to form an ultrasonic image. The ultrasonic image obtained by the processor 116 can be displayed on the display 118 or stored in the memory 124.

[0118] Optionally, the processor 116 may be implemented as software, hardware, firmware or any combination thereof, and may use a single or multiple application specific integrated circuits (ASIC), a single or multiple general purpose integrated circuits, a single or multiple microprocessors, a single or multiple programmable logic devices, or any combination of the aforementioned circuits and / or devices, or other suitable circuits or devices. Furthermore, the processor 116 may control other components in the ultrasonic imaging device 100 to execute the corresponding steps of the methods in various embodiments of the present specification.

[0119] The display 118 is connected to the processor 116, and the display 118 may be a touch screen, a liquid crystal display, etc.; or, the display 118 may be an independent display such as a liquid crystal display, a television, etc., which is independent of the ultrasonic imaging device 100; or, the display 118 may be a display screen of an electronic device such as a smart phone or a tablet computer, etc. The number of the displays 118 may be one or more. For example, the display 118 may include a main screen and a touch screen, wherein the main screen is mainly used to display ultrasonic images, and the touch screen is mainly used for human-computer interaction.

[0120] The display 118 can display the ultrasound image obtained by the processor 116. In addition, while displaying the ultrasound image, the display 118 can also provide the user with a graphical interface for human-computer interaction. One or more controlled objects are set on the graphical interface, and the user is provided with a human-computer interaction device to input operation instructions to control these controlled objects, thereby performing corresponding control operations. For example, an icon is displayed on the graphical interface, and the icon can be operated by the human-computer interaction device to perform a specific function, such as drawing a region of interest box on the ultrasound image.

[0121] Optionally, the ultrasound imaging device 100 may further include other human-computer interaction devices in addition to the display 118, which are connected to the processor 116. For example, the processor 116 may be connected to the human-computer interaction device via an external input / output port, and the external input / output port may be a wireless communication module, or a wired communication module, or a combination of the two. The external input / output port may also be implemented based on USB, bus protocols such as CAN, and / or wired network protocols.

[0122] The human-computer interaction device may include an input device for detecting user input information, which may be, for example, a control instruction for ultrasonic transmission / reception timing, an operation input instruction for drawing points, lines or frames on an ultrasonic image, or other instruction types. The input device may include a keyboard, a mouse, a scroll wheel, a trackball, a mobile input device (such as a mobile device with a touch screen, a mobile phone, etc.), a multi-function knob, etc., or a combination of multiple thereof. The human-computer interaction device may also include an output device such as a printer.

[0123] The ultrasound imaging device 100 may further include a memory 124 for storing instructions executed by the processor, storing received ultrasound echoes, storing ultrasound images, etc. The memory may be a flash memory card, a solid-state memory, a hard disk, etc. It may be a volatile memory and / or a non-volatile memory, a removable memory and / or a non-removable memory, etc.

[0124] It should be understood that Figure 1 The components included in the ultrasonic imaging device 100 are only exemplary, and the ultrasonic imaging device 100 may include more or fewer components, which is not limited in the present application.

[0125] Please refer to Figure 2 As shown, in some embodiments of the present application, a myocardial angiography method is provided based on the above medical device, including:

[0126] Step S100: acquiring multiple frames of ultrasound images of the heart of the target object during myocardial perfusion.

[0127] Myocardial perfusion is a common clinical procedure in this field. After contrast agent is injected into the target object, imaging examination can reflect the activity and damage of the myocardium.

[0128] In some embodiments, when the medical device is an ultrasonic imaging device 100, step S100 includes:

[0129] Step S110 : transmitting ultrasonic waves to the heart of the target object during myocardial perfusion of the target object.

[0130] In this step, "the process of myocardial perfusion" should not be understood mechanically. For example, the target object can be considered to be in the process of myocardial perfusion when the contrast agent is first injected into the target object. For another example, the target object can be considered to be in the process of myocardial perfusion some time after the contrast agent is injected into the target object.

[0131] Step S120: Generate multiple frames of ultrasonic images of the target object during myocardial perfusion according to the ultrasonic echo signal returned by the heart.

[0132] Figure 3 The figure shows a typical ultrasound image of the heart obtained during myocardial perfusion. There is a difference in blood volume between the myocardium and other tissues. When the microbubbles are just crushed, the microbubbles in the myocardium are emptied, and the microbubbles in the cardiac cavity are replenished faster after crushing. The difference between the microbubbles in the myocardium and the cardiac cavity is relatively obvious when the microbubbles are just crushed. With the continuous perfusion of microbubbles, the myocardium will also be filled with microbubbles, and the difference between the myocardium and the cardiac cavity is relatively small at this time. The myocardium and the cardiac cavity can be clearly distinguished by crushing the microbubbles. Figure 3 The shaded part of the inverted U shape is the myocardium.

[0133] In some embodiments, the medical device may be communicatively connected to the ultrasound imaging device 100, and after the ultrasound imaging device 100 generates an ultrasound image, the medical device acquires multiple frames of ultrasound images.

[0134] Step S200: acquiring the ECG signal of the target object during myocardial perfusion.

[0135] In some embodiments, the medical device itself has the function of collecting ECG signals, and the medical device itself can collect ECG signals during the myocardial perfusion of the target object. In other embodiments, the medical device is connected to other medical devices with the function of collecting ECG signals, so as to receive ECG signals collected by other medical devices.

[0136] In the multiple frames of ultrasound images acquired in step S100, each frame of ultrasound image has a corresponding relationship with an electrocardiogram signal at at least one moment. It is assumed that the target object generates n frames of ultrasound images during myocardial perfusion, the i-th frame of ultrasound image is Pi, 1≤i≤n, and the image data of the n-frame ultrasound image is acquired after n time periods, the i-th time period is Ti, 1≤i≤n, wherein the image data of Pi is obtained by processing the ultrasound echo data of Ti, then Pi corresponds to the electrocardiogram signal at any moment in Ti.

[0137] Step A300, identifying the position of the cardiac phase in the electrocardiogram signal during the myocardial perfusion of the target object, the position of the cardiac phase in the electrocardiogram signal represents the time when the cardiac phase occurs. The ED phase is used as an example to illustrate step A300. It can be understood that an ED phase is generated in each cardiac cycle, so the ED phase in the first cardiac cycle (hereinafter referred to as the first ED phase, and the same applies to other cardiac phases) is used as an example.

[0138] In some embodiments, the position of the first cardiac cycle in the ECG signal is first determined. For example, a preset algorithm is used to identify the first R wave appearing in the ECG signal, and the position of the first cardiac cycle in the ECG signal is determined based on the first R wave. Then, based on a preset relative position relationship between the first ED phase and the first cardiac cycle, the position of the first ED phase in the ECG signal is determined, wherein the relative position relationship can be represented by a percentage or a proportional relationship. For example, the length of the first cardiac cycle in the ECG signal is L. Based on experience, the starting point of the first cardiac cycle is used as a reference point, and the position x%*L away from the reference point is used as the position of the first ED phase in the ECG signal.

[0139] In some embodiments, the position of the first cardiac cycle in the ECG signal is first determined, and then the R wave of the first cardiac cycle is identified, and a preset feature point in the R wave is used as a starting point, and the position in the ECG signal that is a preset time distance from the starting point is used as the position of the first ED phase in the ECG signal. For example, after using a preset algorithm to identify the first R wave that appears in the ECG signal, the position of the first cardiac cycle in the ECG signal is determined based on the first R wave, and then the position in the ECG signal m seconds before the peak of the first R wave is used as the position of the first ED phase in the ECG signal.

[0140] In some embodiments, the position of the first cardiac cycle in the ECG signal is first determined, then characteristic points within the first cardiac cycle are identified, these characteristic points are associated with ED phases, and finally the position of the first ED phase in the ECG signal is determined based on the positions of these characteristic points in the ECG signal.

[0141] It should be noted that the above-mentioned method of identifying cardiac phases is only an example. Identifying the position of cardiac phases in electrocardiographic signals is a mature technology at present, so it will not be described in detail here.

[0142] Step A400: Based on the correspondence between each frame of ultrasound image and at least one electrocardiographic signal at a time, the ultrasound image corresponding to the cardiac phase is used as a key frame image of the cardiac phase.

[0143] For example, if the identified ED phase occurs in the time period T2, the P2 ultrasound image frame is used as the key frame image of the ED phase. The key frame image can serve as the basis for subsequent analysis. Since the myocardium is constantly beating, the ultrasound images corresponding to some special positions or moments in the ECG signal have clear, complete or suitable myocardial contours for analysis. One of the purposes of identifying the cardiac phase is to determine the corresponding ultrasound images of the cardiac phase based on the correspondence between the ECG signal and the ultrasound image, and use these ultrasound images as key frame images for subsequent analysis.

[0144] It should be noted that if the position of the same cardiac phase identified by different algorithms in the ECG signal deviates, the key frame image of the cardiac phase may still be the same ultrasound image. For example, the preset first algorithm identifies the ED phase in the first half of T2, and the preset second algorithm identifies the ED phase in the second half of T2. Since the ED phases identified by the two algorithms both fall within T2, and the ultrasound images corresponding to T2 are both P2, the key frame images of the ED phase obtained by the two algorithms are both P2.

[0145] Step A500: at least mark the position of the first cardiac phase in the ECG signal on the displayed ECG graph 10, wherein the ECG graph 10 is generated based on the ECG signal and used to represent the ECG signal, and the first cardiac phase is any cardiac phase.

[0146] Please continue to refer to Figure 3 ,exist Figure 3 The ECG graph 10 is an ECG waveform generated according to the ECG signal, and the position of the first cardiac phase in the ECG signal can be indicated by marking on the ECG waveform. In other embodiments, the ECG graph 10 can also be other graphs that can represent the ECG signal. Figure 3 The first ED phase in the ECG signal is taken as the first cardiac phase. It can be seen that not only the position of the ED phase in the ECG signal is marked, but also the positions of other ES phases and ERF phases in the ECG signal are marked. In other embodiments, only one or several cardiac phases in the cardiac cycle may be marked. In other embodiments, only a certain type of cardiac phase may be marked, for example, only the position of the ED phase is marked on the ECG signal.

[0147] pass Figure 3 The function of the ECG graph 10 and the marking of the cardiac phase is to show the user the position of the cardiac phase in the ECG signal identified by the medical device itself.

[0148] In some embodiments, after marking the position of the first cardiac phase in the electrocardiogram 10, a key frame image of the first cardiac phase is simultaneously displayed, for example, Figure 3 In the embodiment, a key frame image of the first ED phase is displayed at the same time, and the user can observe the key frame image to determine whether it meets expectations.

[0149] In some embodiments, in addition to marking the positions of all cardiac phases in the ECG signal, a phase marker 20 is also specially set for the first cardiac phase. Figure 3 The position of the first ED phase on the ECG waveform is also provided with a phase mark 20 to distinguish it from other cardiac phases. In other embodiments, the first cardiac phase can be distinguished from other cardiac phases by highlighting or displaying other colors.

[0150] Step A600, detecting whether a reset operation of the user for the first cardiac phase is received, if a reset operation is received, executing step A700, otherwise, executing step A800.

[0151] In some embodiments, the phase marker 20 of the first cardiac phase is configured to be movable on the ECG waveform, and the user can input an operation to move the phase marker 20 through the human-computer interaction device to trigger a movement instruction, thereby changing the position of the phase marker 20 on the ECG waveform, for example, by operating a trackball to move the phase marker 20. After the user moves the phase marker 20 to the target position, the user can input a setting instruction through the human-computer interaction device again, and the position of the phase marker 20 on the ECG waveform when the setting instruction is input is the reset position of the first cardiac phase in the ECG signal. That is to say, in the above embodiment, the position of the first cardiac phase in the ECG signal can be changed by moving the phase marker 20.

[0152] It can be understood that the above-mentioned embodiment of resetting the position of the first cardiac phase is only an example, and other interactive methods that can change the first cardiac phase on the ECG waveform fall within the protection scope of the present application.

[0153] Step A700: Re-determine the key frame image of the first cardiac phase. Specifically, the ultrasound image corresponding to the first cardiac phase after the position is reset is used as the key frame image of the first cardiac phase.

[0154] The ultrasound image corresponding to the first cardiac phase after the position is reset may be a different ultrasound image from the original key frame image. For example, if the first ED phase identified by the algorithm is in the second half of T2, and the user moves the first ED phase to the part of the ECG waveform representing the first half of T3, the key frame image of the first ED phase will be changed from P2 to P3.

[0155] The ultrasound image corresponding to the first cardiac phase after the repositioning may also be the same ultrasound image as the original key frame image. For example, if the first ED phase identified by the algorithm is in the first half of T2, and the user moves the first ED phase to the part of the ECG waveform representing the second half of T2, the key frame image of the first cardiac phase after the repositioning does not change.

[0156] It can be understood that, although the key frame image has not changed, the time interval between the cardiac phases or the distance in the electrocardiogram signal has changed.

[0157] In some embodiments, the display simultaneously displays the key frame image of the first cardiac phase, and if the position of the first ECG signal is reset, the display will also update and display the key frame image of the first cardiac phase. If the key frame image of the first cardiac phase does not change, then from the user's perspective, the ultrasound image in the display does not change, and if the key frame image of the first cardiac phase changes, then the ultrasound image in the display will also change accordingly.

[0158] Step A800: keep the key frame image of the first cardiac phase unchanged.

[0159] Through the above steps S100 to A800, the position of the heart phase in the ECG signal is first identified by a preset algorithm or the like, and then any heart phase is marked on the ECG graph 10 in a visual manner for the user to judge whether he is satisfied. If the user is not satisfied, the position of the heart phase in the ECG signal can be adjusted according to experience or the like. In some scenarios, the key frame image of the heart phase will change with the position of the heart phase in the ECG signal.

[0160] In some embodiments, after step A700, the method further includes:

[0161] Check whether the phase synchronization function is enabled. If the phase synchronization function is enabled, execute the phase synchronization step. Otherwise, do not execute the phase synchronization step. The phase synchronization step includes:

[0162] According to the reset position of the first cardiac phase in the electrocardiogram signal, the position of the second cardiac phase in the electrocardiogram signal is reset, so that the position of the second cardiac phase in the electrocardiogram signal changes synchronously with the position of the first cardiac phase in the electrocardiogram signal. The first cardiac phase and the second cardiac phase are of the same type, and the first cardiac phase and the second cardiac phase are located in different cardiac cycles. For example, the first cardiac phase is the ED phase in the first cardiac cycle, and the second cardiac phase is the ED phase in the second cardiac cycle. In other words, some embodiments of the present application also have the function of "phase synchronization", and the user resets the position of a certain type of cardiac phase in one cardiac cycle, and the position of the same type of cardiac phase in one or several other cardiac cycles will also change synchronously, so that the user does not need to set the position of the cardiac phase in the electrocardiogram signal one by one, thereby reducing the user's workload.

[0163] The following takes the case where the first cardiac phase is the first ED phase and the second cardiac phase is the second ED phase as an example to explain how to reset the position of the second cardiac phase in the ECG signal according to the reset position of the first cardiac phase in the ECG signal.

[0164] In some embodiments, a pre-set algorithm may be first used to identify the first cardiac cycle in the ECG signal, and then the first relative position of the first ED phase in the first cardiac cycle may be identified, wherein the first relative position may be characterized by a percentage or a proportional relationship. For example, the length of the first cardiac cycle in the ECG signal is L1, and the starting point of the first cardiac cycle is used as a reference point, and the distance d1 between the first ED phase and the reference point is obtained, then d1 / L1 is calculated, and d1 / L1 is used as the first relative position. Then, the second cardiac cycle is identified in the ECG signal using a pre-set algorithm, and the position of the second ED phase in the ECG signal is reset, so that the second relative position of the second ED phase in the second cardiac cycle is close to or equal to the first relative position. For example, the length of the second cardiac cycle in the ECG signal is L2, and the starting point of the second cardiac cycle is used as a reference point, and the second ED phase is set at a position d2 away from the reference point, and d2 / L2=or≈d1 / L1.

[0165] In some embodiments, a preset algorithm may be used to first identify the first cardiac cycle in the electrocardiogram signal, then identify the R wave in the first cardiac cycle, and then calculate the first time interval between the first ED phase and a preset feature point in the R wave in the first cardiac cycle, for example, calculate the first time interval t1 between the first ED phase and the peak of the R wave in the first cardiac cycle. Then, a preset algorithm may be used to identify the second cardiac cycle in the electrocardiogram signal, and then the position of the second ED phase in the electrocardiogram signal may be reset so that the second time interval between the second ED phase and the preset feature point in the R wave in the second cardiac cycle is close to or equal to the first time interval. For example, the second time interval between the second ED phase and the peak of the R wave in the second cardiac cycle is t2, and the position of the second ED phase in the electrocardiogram signal may be reset so that t2 = or ≈ t1.

[0166] In some embodiments, the phase synchronization function can be achieved by Figure 4 The interface shown is turned on or off. When Sync.Timing is in the ON state, it means that the phase synchronization function is turned on. Conversely, if it is in the OFF state, it means that the phase synchronization function is turned off. In some embodiments, the phase synchronization function can be turned on by default, that is, the phase synchronization step is directly executed without detecting whether the phase synchronization function is turned on. If the user is not satisfied with the synchronized heart phase, he or she can adjust it manually.

[0167] In some embodiments, Figure 5 As shown, after step A400, step A500 may not be performed, but the following steps may be performed:

[0168] Step B500: Displaying the electrocardiogram 10 generated based on the electrocardiogram signal. The difference between step B500 and step A500 is that in step B500, the position of any cardiac phase in the electrocardiogram signal may not be marked.

[0169] Step B600, displaying the phase confirmation control 30, the phase confirmation control 30 is used to trigger a reset instruction corresponding to any cardiac phase based on the user's operation, the reset instruction is used to reset the position of the corresponding cardiac phase in the electrocardiogram signal.

[0170] Step B700, detect whether the corresponding reset instruction of any heart is triggered, if the reset instruction is triggered, execute step B800, otherwise execute step B900.

[0171] Please refer to Figure 6 , Figure 6The phase confirmation control 30 in one embodiment is shown. The phase confirmation control 30 includes a cardiac phase selection menu. The selection menu includes three options: "Set as ED", "Set as ES" and "Set as ERF". When the user clicks "Set as ED", it means that the user wants to reset the ED phase. It can be understood that Figure 6 The phase confirmation control 30 is only an example, and any display control that can set the cardiac phase position based on the user's operation falls within the protection scope of this embodiment.

[0172] Please continue to refer to Figure 6 In some embodiments, in addition to displaying the electrocardiogram 10, a movable phase marker 20 is also displayed on the electrocardiogram 10. When the phase marker 20 is within a certain cardiac cycle, if the user clicks "Set as ED", the position of the phase marker 20 is reset to the position of the ED phase in the electrocardiogram within the cardiac cycle, and if the user clicks "Set as ES", the position of the phase marker 20 is reset to the position of the ES phase in the electrocardiogram within the cardiac cycle. For example, in the initial state, the phase marker 20 is within the first cardiac cycle, and the user moves the phase marker 20 to a certain position and clicks "Set as ED", and the position of the phase marker 20 is reset to the position of the first ED phase in the electrocardiogram. The user continues to move the phase marker 20 within the first cardiac cycle, moves the phase marker 20 to another position of the first cardiac cycle, and clicks "Set as ES", and the position of the phase marker 20 is reset to the position of the first ED phase in the electrocardiogram. The user continues to move the phase marker 20, moves the phase marker 20 to a certain position in the second cardiac cycle, and then clicks "Set as ERF", so that the position of the phase marker 20 is reset to the position of the second ERF phase in the electrocardiogram signal.

[0173] Step B800: Re-determine the key frame image of the cardiac phase. Specifically, the ultrasound image corresponding to the cardiac phase after the position is reset is used as the key frame image of the cardiac phase.

[0174] Step B900: Keep the key frame images of the cardiac phases unchanged. That is, for the cardiac phases whose positions are not reset, the key frame images of these cardiac phases remain unchanged.

[0175] In step B500, the positions of all cardiac phases may also be marked on the electrocardiogram 10. In some embodiments, after the positions of each cardiac phase are marked on the electrocardiogram 10, the cardiac phase selected by the user based on the phase confirmation control 30 has different display modes. Figure 7In FIG. 3 , the marks of the ED phase, ES phase, and ERF phase are all green. When the user clicks “Set as ED” in the phase confirmation control 30, the mark of the ED phase changes from green to yellow. Figure 7 The phase synchronization function is also enabled, that is, when the user clicks "Set as ED" to set the ED phase in any cardiac cycle, the position of the ED phase in other cardiac cycles will change synchronously.

[0176] In some embodiments, Figure 8 As shown, after step S200, step A300 is not executed, but the following is executed:

[0177] Step C300: displaying the electrocardiogram 10 generated based on the electrocardiogram signal.

[0178] That is to say, in this embodiment, after acquiring the electrocardiogram signal, the position of the cardiac phase in the electrocardiogram signal may not be identified, but only the electrocardiogram 10 may be displayed to the user.

[0179] Step C400, detecting the setting operation of the cardiac phase input by the user for the ECG graph 10, and setting the position of the cardiac phase in the ECG signal of the target object during myocardial perfusion based on the setting operation, wherein the position of the cardiac phase in the ECG signal represents the time when the cardiac phase occurs.

[0180] It can be seen that in this embodiment, the position of the cardiac phase in the electrocardiogram signal is set by the user, and the setting method can adopt the above-mentioned phase confirmation control 30 or other methods.

[0181] Step C500: Based on the correspondence between each frame of ultrasound image and at least one electrocardiographic signal at a time, the ultrasound image corresponding to the cardiac phase is used as a key frame image of the cardiac phase.

[0182] Through the above steps C300 to C500, the position of each cardiac phase in the ECG signal can be determined by the user. After the cardiac phase is determined, the medical device obtains the key frame of each cardiac phase based on the correspondence between the ultrasound image and the ECG signal.

[0183] After the key frame images of each cardiac phase are determined, the myocardium can be analyzed based on these key frame images. First, the region of interest (ROI) is determined in the key frame image. In some embodiments, the region of interest in the key frame image is identified according to a preset region of interest recognition algorithm. The algorithm for identifying ROI is a mature technology and is not described in detail here. In other embodiments, a user's drawing operation is received, and the region of interest is determined in the key frame image. For example, the user draws a closed area on the key frame image through a human-computer interaction device, and the medical device uses the area as the region of interest. In some embodiments, such as Fig. 9 As shown, after determining the region of interest of the key frame image, it includes:

[0184] Step N100: Acquire a key frame image of a third cardiac phase and a key frame image of a fourth cardiac phase, where the third cardiac phase and the fourth cardiac phase are two cardiac phases in the same cardiac cycle.

[0185] For example, the third cardiac phase is the first ED phase, and the fourth cardiac phase is the first ERF phase. For another example, the third cardiac phase is the second ED phase, and the fourth cardiac phase is the second ES phase.

[0186] Step N200: determining a transition frame image, where the transition frame image is an ultrasound image between the key frame image of the third cardiac phase and the key frame image of the fourth cardiac phase.

[0187] Step N300, obtaining the change time from the third cardiac phase to the fourth cardiac phase.

[0188] Step N400: Draw a region of interest in the transition frame image according to the region of interest in the key frame image of the third cardiac phase, the region of interest in the key frame image of the fourth cardiac phase, and the change time.

[0189] For example, the third cardiac phase is the first ED phase, the fourth cardiac phase is the first ERF phase, and there are two ultrasound images between the key frame image of the first ED phase and the key frame image of the first ERF phase, then these two ultrasound images are transition frame images. The change time from the first ED phase to the first ERF phase is calculated, and finally, the region of interest is drawn in the transition frame image according to the region of interest in the key frame image of the first ED phase, the region of interest in the key frame image of the first ERF phase, and the time interval between the first ED phase and the first ERF phase.

[0190] Based on step N100 to step N200, it can be known that the region of interest in the transition frame image is drawn from the regions of interest of at least two key frame images, rather than being obtained according to the contour of the myocardial part in the image as in the key frame image. As described above, the myocardial contour in the key frame image has the characteristics of being complete or clear, so that the region of interest of the key frame image can be directly obtained by processing the key frame image, and the region of interest in the transition frame image may or may not overlap with the myocardial contour in the image intuitively.

[0191] The region of interest in the transition frame image is determined by at least the following factors: ① the region of interest of the "head" and the "tail", for example, in the above example, the region of interest of the "head" is the region of interest in the key frame image of the first ED phase, and the region of interest of the "tail" is the region of interest in the key frame image of the first ERF phase; ② the time interval between the "head" and the "tail", for example, in the above example, the "head" is the first ED phase and the "tail" is the first ERF phase. When the user resets the position of a certain cardiac phase in the ECG signal, the above factor ① may change or may not change, while the above factor ② will change when the position of other cardiac phases remains unchanged, causing the region of interest in the transition frame image to change. It can be seen that the user resetting the position of the cardiac phase in the ECG signal is of great significance for subsequent image analysis.

[0192] The myocardial contrast imaging method and ultrasonic imaging device display the recognition results of the cardiac phase to the user in a visual manner, and allow the user to manually adjust the position of the cardiac phase, so as to obtain a more accurate or user-expected cardiac phase. In addition, a phase synchronization function is also provided to further reduce the workload of the user and improve the work efficiency of the user.

[0193] This document is described with reference to various exemplary embodiments. However, those skilled in the art will recognize that changes and modifications may be made to the exemplary embodiments without departing from the scope of this document. For example, various operating steps and components for performing the operating steps may be implemented in different ways (e.g., one or more steps may be deleted, modified, or incorporated into other steps) depending on the specific application or considering any number of cost functions associated with the operation of the system.

[0194] In addition, as will be appreciated by those skilled in the art, the principles of the present invention may be reflected in a computer program product on a computer-readable storage medium, which is pre-installed with a computer-readable program code. Any tangible, non-temporary computer-readable storage medium may be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD-ROMs, DVDs, Blu Ray disks, etc.), flash memory, and / or the like. These computer program instructions may be loaded onto a general-purpose computer, a special-purpose computer, or other programmable data processing device to form a machine, so that these instructions executed on a computer or other programmable data processing device may generate a device that implements a specified function. These computer program instructions may also be stored in a computer-readable memory, which may instruct a computer or other programmable data processing device to operate in a specific manner, so that the instructions stored in the computer-readable memory may form a manufactured product, including an implementation device that implements a specified function. The computer program instructions may also be loaded onto a computer or other programmable data processing device, so that a series of operating steps are performed on the computer or other programmable device to produce a computer-implemented process, so that the instructions executed on the computer or other programmable device may provide steps for implementing a specified function.

[0195] Although the principles of this invention have been shown in various embodiments, many modifications of structures, arrangements, proportions, elements, materials and components particularly suitable for specific environments and operational requirements can be used without departing from the principles and scope of this invention. The above modifications and other changes or amendments will be included in the scope of this invention.

[0196] The foregoing specific description has been described with reference to various embodiments. However, those skilled in the art will recognize that various modifications and changes can be made without departing from the scope of the present disclosure. Therefore, the consideration of the present disclosure will be illustrative rather than restrictive, and all these modifications will be included in its scope. Similarly, the advantages, other advantages and solutions to the problems of various embodiments have been described above. However, the benefits, advantages, solutions to the problems and any elements that can produce these, or make them more clear, should not be interpreted as critical, necessary or necessary. The term "include" and any other variants used in this article are all non-exclusive inclusions, so that the process, method, article or device including the list of elements not only includes these elements, but also includes other elements that are not explicitly listed or do not belong to the process, method, system, article or device. In addition, the term "coupled" and any other variants used in this article refer to physical connections, electrical connections, magnetic connections, optical connections, communication connections, functional connections and / or any other connections.

[0197] Those skilled in the art will appreciate that many changes may be made to the details of the above-described embodiments without departing from the basic principles of the invention. Therefore, the scope of the invention should be determined from the following claims.

Claims

1. An ultrasonic imaging device, characterized in that: include: monitor; Ultrasound probe; A transmitting circuit, used for stimulating the ultrasonic probe to transmit ultrasonic waves to a target object; A receiving circuit, used for controlling the ultrasonic probe to receive the ultrasonic echo to obtain the ultrasonic echo signal; Processor for: controlling the ultrasound probe to transmit ultrasound waves to the heart of the target object during myocardial perfusion of the target object; generating a multi-frame ultrasound image of the target object during myocardial perfusion according to the ultrasound echo signal returned by the heart; Acquiring an electrocardiogram signal of a target object during myocardial perfusion, wherein each frame of the ultrasound image generated during the myocardial perfusion of the target object has a corresponding relationship with the electrocardiogram signal at at least one moment; Identify the position of a cardiac phase in the electrocardiogram signal during myocardial perfusion of the target object, wherein the position of the cardiac phase in the electrocardiogram signal represents the time when the cardiac phase occurs; Based on the correspondence between each frame of the ultrasound image and at least one electrocardiographic signal at a time, taking the ultrasound image corresponding to the cardiac phase as a key frame image of the cardiac phase; generating an electrocardiogram representing the electrocardiogram according to the electrocardiogram signal; Controlling the display to display the electrocardiogram, at least marking the position of a first cardiac phase in the electrocardiogram on the electrocardiogram, wherein the first cardiac phase is any one of the cardiac phases; Detect whether a reset operation for the first cardiac phase by the user is received; if the reset operation is received, reset the position of the first cardiac phase in the electrocardiogram signal according to the reset operation, and use the ultrasound image corresponding to the first cardiac phase after the reset position as the key frame image of the first cardiac phase; if the reset operation is not received, keep the key frame image of the first cardiac phase unchanged.

2. The ultrasonic imaging device according to claim 1, characterized in that: After resetting the position of the first cardiac phase in the electrocardiographic signal according to the reset operation, the processor is further configured to perform a phase synchronization step, the phase synchronization step comprising: Resetting the position of the second cardiac phase in the electrocardiogram signal according to the reset position of the first cardiac phase in the electrocardiogram signal, so that the position of the second cardiac phase in the electrocardiogram signal changes synchronously with the position of the first cardiac phase in the electrocardiogram signal; The first cardiac phase and the second cardiac phase are of the same type, and the first cardiac phase and the second cardiac phase are in different cardiac cycles.

3. The ultrasonic imaging device according to claim 1, characterized in that: After resetting the position of the first cardiac phase in the electrocardiographic signal according to the reset operation, the processor is further configured to: Detecting whether a time phase synchronization function is turned on, wherein the time phase synchronization function is turned on or off based on a user operation; If the time phase synchronization function is turned on, the time phase synchronization step is performed, otherwise, the time phase synchronization step is not performed, and the time phase synchronization step includes: Resetting the position of the second cardiac phase in the electrocardiogram signal according to the reset position of the first cardiac phase in the electrocardiogram signal, so that the position of the second cardiac phase in the electrocardiogram signal changes synchronously with the position of the first cardiac phase in the electrocardiogram signal; The first cardiac phase and the second cardiac phase are of the same type, and the first cardiac phase and the second cardiac phase are in different cardiac cycles.

4. The ultrasonic imaging device according to claim 2 or 3, characterized in that: The step of resetting the position of the second cardiac phase in the electrocardiogram signal according to the re-set position of the first cardiac phase in the electrocardiogram signal comprises: Determine a first cardiac cycle in which the first cardiac phase occurs; identifying a first relative position of the first cardiac phase in the first cardiac cycle; determining a second cardiac cycle in which the second cardiac phase occurs; The position of the second cardiac phase in the electrocardiographic signal is reset so that a second relative position of the second cardiac phase in the second cardiac cycle is close to or equal to the first relative position.

5. The ultrasonic imaging device according to claim 2 or 3, characterized in that: The step of resetting the position of the second cardiac phase in the electrocardiogram signal according to the re-set position of the first cardiac phase in the electrocardiogram signal comprises: Determine a first cardiac cycle in which the first cardiac phase occurs; identifying an R wave in the first cardiac cycle; calculating a first time interval between the first cardiac phase and a preset characteristic point in the R wave in the first cardiac cycle; determining a second cardiac cycle in which the second cardiac phase occurs; identifying an R wave in the second cardiac cycle; The position of the second cardiac phase in the electrocardiographic signal is reset so that a second time interval between the second cardiac phase and a preset feature point in an R wave in a second cardiac cycle is close to or equal to the first time interval.

6. The ultrasonic imaging device according to claim 1, characterized in that: After marking the position of the first cardiac phase in the ECG signal on the ECG graph, the processor is further used to control the display to simultaneously display the key frame image of the first cardiac phase, and to update the key frame image of the first cardiac phase if the position of the first cardiac phase in the ECG signal is reset.

7. The ultrasonic imaging device according to claim 1, characterized in that: The step of at least marking the position of the first cardiac phase in the electrocardiogram includes: marking the positions of all identified cardiac phases in the electrocardiogram on the electrocardiogram.

8. The ultrasonic imaging device according to claim 1, characterized in that: The step of marking the position of the first cardiac phase in the electrocardiogram on the electrocardiogram includes: generating a phase marker indicative of the first cardiac phase; According to the position of the first cardiac phase in the electrocardiogram, a phase mark of the first cardiac phase is displayed at a corresponding position of the electrocardiogram.

9. The ultrasonic imaging device according to claim 8, characterized in that: The detecting whether a user's reset operation for the first cardiac phase is received, and if the reset operation is received, resetting the position of the first cardiac phase in the electrocardiogram signal according to the reset operation, comprises: detecting whether a movement instruction triggered by a user's operation on the phase mark is received, and if the movement instruction is detected, moving the phase mark on the electrocardiogram according to the movement instruction; detecting whether a setting instruction input by a user is received, and if the setting instruction is detected, determining the position of the phase mark on the electrocardiogram when the setting instruction is detected; The position of the first cardiac phase in the electrocardiogram is reset according to the position of the phase mark on the electrocardiogram when the setting instruction is detected.

10. The ultrasonic imaging device according to claim 1, characterized in that: The processor is further configured to: Identify the region of interest in the key frame image according to a preset region of interest identification algorithm; or A drawing operation of a user is received, and a region of interest is determined in the key frame image.

11. The ultrasonic imaging device according to claim 10, characterized in that: The processor is further configured to: Acquire a key frame image of a third cardiac phase and a key frame image of a fourth cardiac phase, wherein the third cardiac phase and the fourth cardiac phase are two cardiac phases in the same cardiac cycle; Determine a transition frame image, where the transition frame image is an ultrasound image between the key frame image of the third cardiac phase and the key frame image of the fourth cardiac phase; Acquiring a change time from the third cardiac phase to the fourth cardiac phase; The region of interest is drawn in the transition frame image according to the region of interest in the key frame image of the third cardiac phase, the region of interest in the key frame image of the fourth cardiac phase, and the change time.

12. The ultrasonic imaging device according to claim 1, characterized in that: For any cardiac phase, the identifying the position of the cardiac phase in the electrocardiogram signal during the myocardial perfusion process of the target object includes: Determine the cardiac cycle in which the cardiac phase is located, and determine the position of the cardiac phase in the electrocardiogram signal according to a preset relative position relationship between the cardiac phase and the cardiac cycle in which the cardiac phase is located; or Determine the cardiac cycle in which the cardiac phase is located, identify the R wave of the cardiac cycle, take a preset characteristic point in the R wave as a starting point, and use the position in the electrocardiogram signal that is a preset time distance from the starting point as the position of the cardiac phase in the electrocardiogram signal; Determine the cardiac cycle in which the cardiac phase is located, identify the characteristic points of the electrocardiogram signal in the cardiac cycle, wherein the characteristic points are associated with the cardiac phase, and determine the position of the cardiac phase in the electrocardiogram signal according to the position of the characteristic points in the electrocardiogram signal.

13. The ultrasonic imaging device according to claim 1, characterized in that: The identifying of the position of the cardiac phase in the electrocardiogram signal during myocardial perfusion of the target object includes: processing the electrocardiogram signal based on a preset phase identification algorithm, and identifying the positions of at least two of the end-systolic phase, the end-rapid filling phase, and the end-diastolic phase in the electrocardiogram signal.

14. An ultrasonic imaging device, characterized in that: include: monitor; Ultrasound probe; A transmitting circuit, used for stimulating the ultrasonic probe to transmit ultrasonic waves to a target object; A receiving circuit, used for controlling the ultrasonic probe to receive the ultrasonic echo to obtain the ultrasonic echo signal; Processor for: controlling the ultrasound probe to transmit ultrasound waves to the heart of the target object during myocardial perfusion of the target object; generating a multi-frame ultrasound image of the target object during myocardial perfusion according to the ultrasound echo signal returned by the heart; Acquiring an electrocardiogram signal of a target object during myocardial perfusion, wherein each frame of the ultrasound image generated during the myocardial perfusion of the target object has a corresponding relationship with the electrocardiogram signal at at least one moment; Identify the position of a cardiac phase in the electrocardiogram signal during myocardial perfusion of the target object, wherein the position of the cardiac phase in the electrocardiogram signal represents the time when the cardiac phase occurs; Based on the correspondence between each frame of the ultrasound image and at least one electrocardiographic signal at a time, taking the ultrasound image corresponding to the cardiac phase as a key frame image of the cardiac phase; generating an electrocardiogram representing the electrocardiogram according to the electrocardiogram signal; Controlling the display to display the electrocardiogram; Controlling the display to display a phase confirmation control, wherein the phase confirmation control is used to trigger a reset instruction corresponding to any cardiac phase based on a user's operation, wherein the reset instruction is used to reset the position of the corresponding cardiac phase in the electrocardiogram signal; It is detected whether the reset instruction corresponding to any heart phase is triggered. If the reset instruction is triggered, the ultrasound image corresponding to the heart phase after the position is reset is used as the key frame image of the heart phase.

15. The ultrasonic imaging device according to claim 14, characterized in that: The processor is also used to: generating a movable phase mark on the electrocardiogram; If the reset instruction is triggered, the position of the phase mark on the electrocardiogram when the reset instruction is triggered is obtained, and the position of the heart phase corresponding to the reset instruction in the electrocardiogram is reset according to the position.

16. The ultrasonic imaging device according to claim 14, characterized in that: The phase confirmation control includes a selection menu of cardiac phases, and the phase confirmation control triggers a reset instruction of the cardiac phase based on a selection operation of the cardiac phase in the selection menu.

17. An ultrasonic imaging device, characterized in that: include: monitor; Ultrasound probe; A transmitting circuit, used for stimulating the ultrasonic probe to transmit ultrasonic waves to a target object; A receiving circuit, used for controlling the ultrasonic probe to receive the ultrasonic echo to obtain the ultrasonic echo signal; Processor for: controlling the ultrasound probe to transmit ultrasound waves to the heart of the target object during myocardial perfusion of the target object; generating a multi-frame ultrasound image of the target object during myocardial perfusion according to the ultrasound echo signal returned by the heart; Acquiring an electrocardiogram signal of a target object during myocardial perfusion, wherein each frame of the ultrasound image generated during the myocardial perfusion of the target object has a corresponding relationship with the electrocardiogram signal at at least one moment; generating an electrocardiogram representing the electrocardiogram according to the electrocardiogram signal; Controlling the display to display the electrocardiogram; Detecting a setting operation of a cardiac phase input by a user for the electrocardiogram, and setting a position of a cardiac phase during myocardial perfusion of the target object in the electrocardiogram based on the setting operation, wherein the position of the cardiac phase in the electrocardiogram represents a time when the cardiac phase occurs; Based on the correspondence between each frame of the ultrasonic image and the electrocardiographic signal at at least one moment, the ultrasonic image corresponding to the cardiac phase is used as a key frame image of the cardiac phase.

18. A myocardial contrast imaging method, characterized in that: include: transmitting ultrasound waves to the heart of the target subject during myocardial perfusion of the target subject; generating a multi-frame ultrasound image of the target object during myocardial perfusion according to the ultrasound echo signal returned by the heart; Acquiring an electrocardiogram signal of a target object during myocardial perfusion, wherein each frame of the ultrasound image generated during the myocardial perfusion of the target object has a corresponding relationship with the electrocardiogram signal at at least one moment; Identify the position of a cardiac phase in the electrocardiogram signal during myocardial perfusion of the target object, wherein the position of the cardiac phase in the electrocardiogram signal represents the time when the cardiac phase occurs; Based on the correspondence between each frame of the ultrasound image and at least one electrocardiographic signal at a time, taking the ultrasound image corresponding to the cardiac phase as a key frame image of the cardiac phase; generating an electrocardiogram representing the electrocardiogram according to the electrocardiogram signal; Display the electrocardiogram, and at least mark the position of the first cardiac phase in the electrocardiogram on the electrocardiogram, wherein the first cardiac phase is any one of the cardiac phases; Detect whether a reset operation for the first cardiac phase by the user is received; if the reset operation is received, reset the position of the first cardiac phase in the electrocardiogram signal according to the reset operation, and use the ultrasound image corresponding to the first cardiac phase after the reset position as the key frame image of the first cardiac phase; if the reset operation is not received, keep the key frame image of the first cardiac phase unchanged.

19. The method according to claim 18, characterized in that After resetting the position of the first cardiac phase in the electrocardiographic signal according to the reset operation, the method further includes: executing a phase synchronization step, wherein the phase synchronization step includes: Resetting the position of the second cardiac phase in the electrocardiogram signal according to the reset position of the first cardiac phase in the electrocardiogram signal, so that the position of the second cardiac phase in the electrocardiogram signal changes synchronously with the position of the first cardiac phase in the electrocardiogram signal; The first cardiac phase and the second cardiac phase are of the same type, and the first cardiac phase and the second cardiac phase are in different cardiac cycles.

20. The method of claim 18, wherein: After resetting the position of the first cardiac phase in the electrocardiographic signal according to the reset operation, the method further includes: Detecting whether a time phase synchronization function is turned on, wherein the time phase synchronization function is turned on or off based on a user operation; If the time phase synchronization function is turned on, the time phase synchronization step is performed, otherwise, the time phase synchronization step is not performed, and the time phase synchronization step includes: Resetting the position of the second cardiac phase in the electrocardiogram signal according to the reset position of the first cardiac phase in the electrocardiogram signal, so that the position of the second cardiac phase in the electrocardiogram signal changes synchronously with the position of the first cardiac phase in the electrocardiogram signal; The first cardiac phase and the second cardiac phase are of the same type, and the first cardiac phase and the second cardiac phase are in different cardiac cycles.

21. A myocardial contrast imaging method, characterized in that: include: transmitting ultrasound waves to the heart of the target subject during myocardial perfusion of the target subject; generating a multi-frame ultrasound image of the target object during myocardial perfusion according to the ultrasound echo signal returned by the heart; Acquiring an electrocardiogram signal of a target object during myocardial perfusion, wherein each frame of the ultrasound image generated during the myocardial perfusion of the target object has a corresponding relationship with the electrocardiogram signal at at least one moment; generating an electrocardiogram representing the electrocardiogram according to the electrocardiogram signal; Displaying the electrocardiogram; Displaying a phase confirmation control, wherein the phase confirmation control is used to trigger a corresponding reset instruction for any cardiac phase based on a user's operation, wherein the reset instruction is used to reset the position of the corresponding cardiac phase in the electrocardiogram signal; It is detected whether the reset instruction corresponding to any heart phase is triggered. If the reset instruction is triggered, the ultrasound image corresponding to the heart phase after the position is reset is used as the key frame image of the heart phase.

22. A myocardial contrast imaging method, characterized in that: include: transmitting ultrasound waves to the heart of the target subject during myocardial perfusion of the target subject; generating a multi-frame ultrasound image of the target object during myocardial perfusion according to the ultrasound echo signal returned by the heart; Acquiring an electrocardiogram signal of a target object during myocardial perfusion, wherein each frame of the ultrasound image generated during the myocardial perfusion of the target object has a corresponding relationship with the electrocardiogram signal at at least one moment; generating an electrocardiogram representing the electrocardiogram according to the electrocardiogram signal; Displaying the electrocardiogram; Detecting a setting operation of a cardiac phase input by a user for the electrocardiogram, and setting a position of a cardiac phase during myocardial perfusion of the target object in the electrocardiogram based on the setting operation, wherein the position of the cardiac phase in the electrocardiogram represents a time when the cardiac phase occurs; Based on the correspondence between each frame of the ultrasonic image and the electrocardiographic signal at at least one moment, the ultrasonic image corresponding to the cardiac phase is used as a key frame image of the cardiac phase.

23. A myocardial angiography method, characterized in that: include: Acquire multiple frames of ultrasound images of the heart of the target object during myocardial perfusion; Acquiring an electrocardiogram signal of a target object during myocardial perfusion, wherein each frame of the ultrasound image generated during the myocardial perfusion of the target object has a corresponding relationship with the electrocardiogram signal at at least one moment; Identify the position of a cardiac phase in the electrocardiogram signal during myocardial perfusion of the target object, wherein the position of the cardiac phase in the electrocardiogram signal represents the time when the cardiac phase occurs; Based on the correspondence between each frame of the ultrasound image and at least one electrocardiographic signal at a time, taking the ultrasound image corresponding to the cardiac phase as a key frame image of the cardiac phase; generating an electrocardiogram representing the electrocardiogram according to the electrocardiogram signal; Display the electrocardiogram, and at least mark the position of the first cardiac phase in the electrocardiogram on the electrocardiogram, wherein the first cardiac phase is any one of the cardiac phases; Detect whether a reset operation for the first cardiac phase by the user is received; if the reset operation is received, reset the position of the first cardiac phase in the electrocardiogram signal according to the reset operation, and use the ultrasound image corresponding to the first cardiac phase after the reset position as the key frame image of the first cardiac phase; if the reset operation is not received, keep the key frame image of the first cardiac phase unchanged.

24. A myocardial angiography method, characterized in that: include: Acquire multiple frames of ultrasound images of the heart of the target object during myocardial perfusion; Acquiring an electrocardiogram signal of a target object during myocardial perfusion, wherein each frame of the ultrasound image generated during the myocardial perfusion of the target object has a corresponding relationship with the electrocardiogram signal at at least one moment; Identify the position of a cardiac phase in the electrocardiogram signal during myocardial perfusion of the target object, wherein the position of the cardiac phase in the electrocardiogram signal represents the time when the cardiac phase occurs; Based on the correspondence between each frame of the ultrasound image and at least one electrocardiographic signal at a time, taking the ultrasound image corresponding to the cardiac phase as a key frame image of the cardiac phase; generating an electrocardiogram representing the electrocardiogram according to the electrocardiogram signal; Displaying the electrocardiogram; Displaying a phase confirmation control, wherein the phase confirmation control is used to trigger a corresponding reset instruction for any cardiac phase based on a user's operation, wherein the reset instruction is used to reset the position of the corresponding cardiac phase in the electrocardiogram signal; It is detected whether the reset instruction corresponding to any heart phase is triggered. If the reset instruction is triggered, the ultrasound image corresponding to the heart phase after the position is reset is used as the key frame image of the heart phase.

25. A myocardial contrast imaging method, characterized in that: include: Acquire multiple frames of ultrasound images of the heart of the target object during myocardial perfusion; Acquiring an electrocardiogram signal of a target object during myocardial perfusion, wherein each frame of the ultrasound image generated during the myocardial perfusion of the target object has a corresponding relationship with the electrocardiogram signal at at least one moment; generating an electrocardiogram representing the electrocardiogram according to the electrocardiogram signal; Displaying the electrocardiogram; Detecting a setting operation of a cardiac phase input by a user for the electrocardiogram, and setting a position of a cardiac phase during myocardial perfusion of the target object in the electrocardiogram based on the setting operation, wherein the position of the cardiac phase in the electrocardiogram represents a time when the cardiac phase occurs; Based on the correspondence between each frame of the ultrasonic image and the electrocardiographic signal at at least one moment, the ultrasonic image corresponding to the cardiac phase is used as a key frame image of the cardiac phase.

26. A medical device, characterized in that: Memory, used to store programs; A processor, configured to implement the method according to any one of claims 18 to 25 by executing the program stored in the memory.

27. A computer-readable storage medium, characterized in that: The medium stores a program, which can be executed by a processor to implement the method according to any one of claims 18 to 25.

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