Soothing and anti-wrinkle composition, preparation method thereof and soothing and anti-wrinkle essence

Abstract

The invention relates to the technical field of cosmetics, in particular to a soothing and anti-wrinkle composition, a preparation method of the soothing and anti-wrinkle composition and soothing and anti-wrinkle essence. The soothing and anti-wrinkle composition is prepared from the following raw materials in percentage by mass: 1 to 5 percent of supramolecular blue copper peptide solution, 0.01 to 0.2 percent of 17 type collagen solution, 0.05 to 10 percent of III type collagen, 0.04 to 0.3 percent of bilberry fruit extract, 0.06 to 1.5 percent of crocus sativus flower extract, 1 to 10 percent of multiple hyaluronic acid and the balance of solvent. The soothing and anti-wrinkle composition can give full play to the synergistic effect of the raw materials, so that the composition has good soothing and anti-wrinkle effects, stability and applicability. The preparation method of the soothing anti-wrinkle composition is simple and efficient in process, convenient to operate and control and beneficial to industrial production. The soothing and anti-wrinkle essence disclosed by the invention adopts the soothing and anti-wrinkle composition, has a good soothing and anti-wrinkle effect, and provides an efficient, convenient and safe skin care product.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetics, and in particular to a soothing and anti-wrinkle composition and a preparation method thereof, and a soothing and anti-wrinkle essence. Background Art

[0002] In today's fast-paced life, the skin faces multiple pressures from the internal and external environment, such as ultraviolet radiation, air pollution, irregular work and rest, etc., which can easily lead to problems such as dryness, sensitivity, and wrinkles. Consumers are increasingly demanding cosmetics that can effectively soothe the skin, resist wrinkles, and are easy to use.

[0003] There are some shortcomings in the soothing and anti-wrinkle products currently on the market. Many products either focus on immediate effects and ignore the long-term health of the skin, or have a single ingredient and cannot comprehensively solve various skin problems. At the same time, the usage of most products is relatively fixed and cannot fully adapt to the physiological characteristics and demand changes of the skin at different times. Therefore, it is of great practical significance and market value to develop a composition that can integrate multiple effective ingredients, synergistically exert soothing and anti-wrinkle effects, and achieve all-day skin care. Summary of the invention

[0004] In order to overcome the shortcomings and deficiencies in the prior art, the present invention aims to provide a soothing and anti-wrinkle composition and a preparation method thereof, wherein the soothing and anti-wrinkle composition combines supramolecular blue copper peptide, type 17 collagen, type III collagen, blueberry fruit extract, saffron flower extract, multiple hyaluronic acids and solvents to give full play to the synergistic effect of each raw material, improve the soothing and anti-wrinkle effect of the composition, and enhance its stability and applicability. The preparation method of the soothing and anti-wrinkle composition has a simple process, high production efficiency, and is conducive to industrial production.

[0005] Another object of the present invention is to provide a soothing and anti-wrinkle essence, which has good soothing and anti-wrinkle effects by adding the soothing and anti-wrinkle composition, is safe and efficient, convenient and safe to use, and has good skin care effects.

[0006] The objective of the present invention is achieved through the following technical scheme: a soothing and anti-wrinkle composition, comprising the following raw materials in mass percentage: 1-5% supramolecular blue copper peptide solution, 0.01-0.2% type 17 collagen solution, 0.05-10% type III collagen, 0.04-0.3% blueberry fruit extract, 0.06-1.5% saffron flower extract, 1-10% multiple hyaluronic acid, and the remainder of solvent.

[0007] The soothing and anti-wrinkle composition provided by the present invention is an organic combination of supramolecular blue copper peptide, type 17 collagen, type III collagen, blueberry fruit extract, saffron flower extract, multiple hyaluronic acids and solvents in a specific ratio, which exerts the synergistic effect of each component, improves the soothing and anti-wrinkle effect, and enhances its stability and applicability, thereby providing consumers with an efficient, convenient and safe skin care product.

[0008] Furthermore, the type 17 collagen solution includes the following raw materials in mass percentage: 45-55% glycerol, 13-19% butylene glycol, 0.03-0.07% soluble collagen, and 30-36% water. Type 17 collagen is mainly distributed in the junction of the epidermis and dermis of the skin, and is essential for maintaining the stability of the skin. It can enhance the adhesion between cells, strengthen the barrier structure of the skin, prevent the invasion of external harmful substances, and reduce the occurrence of skin allergies and other problems; at the cellular level, type 17 collagen can regulate the proliferation and differentiation of keratinocytes; it helps maintain the elasticity and toughness of the skin.

[0009] Furthermore, the supramolecular blue copper peptide solution includes the following raw materials in mass percentage: 2-4% tripeptide-1 copper, 8-12% hydroxyethylpiperazineethane sulfonic acid, 2-3% betaine, 6-9% 1,3-propylene glycol, 69-75% water, and 4-6% 1,2-pentanediol. The supramolecular blue copper peptide can promote the metabolism of skin cells, stimulate cell regeneration, and has a good effect on the repair of damaged skin; it can activate fibroblasts, promote the synthesis of collagen and elastic fibers, effectively reduce wrinkles, and enhance the firmness of the skin; it has anti-inflammatory properties, can inhibit the release of inflammatory factors, and reduce skin inflammatory reactions.

[0010] Furthermore, the multiple hyaluronic acid comprises the following raw materials in percentage by weight: 2-3% sodium hyaluronate cross-linked polymer, 2-3% sodium hyaluronate, 0.2-0.4% hydrolyzed sodium hyaluronate, 0.03-0.07% hyaluronic acid, 0.03-0.07% hydrolyzed hyaluronic acid, 0.1-0.3% acetylated sodium hyaluronate, 0.03-0.07% hydroxypropyltrimethylammonium chloride hyaluronic acid, 0.05-0.15% hydrolyzed glycosaminoglycan, 0.2-0.4% 1,2-hexanediol, 0.4-0.9% 1,3-propylene glycol, 0.03-0.07% caprylhydroxamic acid, and 90-95% water.

[0011] Furthermore, the preparation method of the multiple hyaluronic acid comprises the following steps: (A1) adding water to a container, stirring and adding sodium hyaluronate cross-linked polymer, sodium hyaluronate, hydrolyzed sodium hyaluronate, hyaluronic acid, hydrolyzed hyaluronic acid, acetylated sodium hyaluronate, hydroxypropyltrimethylammonium chloride hyaluronic acid, and hydrolyzed glycosaminoglycan, stirring evenly, raising the temperature to 75-80° C., and stirring at a constant temperature until completely dissolved to obtain a mixture A1; (A2) cooling the mixture A1 to 40-45° C., adding 1,2-hexanediol, 1,3-propylene glycol and octanoylhydroxamic acid, and stirring until the mixture becomes transparent and free of impurities, to obtain a mixture A2; (A3) Cooling the mixture A2 to 35-38° C. and then filtering the mixture to obtain a multiple hyaluronic acid complex.

[0012] Furthermore, the solvent is at least one of ionized water and alcohol solvents; the alcohol solvent is at least one of 1,3-propylene glycol, butylene glycol, dipropylene glycol, 1,2-hexanediol and glycerol.

[0013] Furthermore, the solvent comprises the following raw materials in percentage by mass: 3-6% glycerol, 1-3% 1,2-hexanediol, and the balance water.

[0014] The present invention prepares a soothing and anti-wrinkle composition by compounding supramolecular blue copper peptide solution, type 17 collagen solution, type III collagen, blueberry fruit extract, saffron flower extract and multiple hyaluronic acids, and each raw material achieves good coordination and has a synergistic effect. Type III collagen is one of the important components of skin elastic fibers, and plays a key role in maintaining the elasticity and resilience of the skin; there are many hydrophilic groups in the molecular structure, which can bind a large number of water molecules and moisturize the skin; when the skin is injured, type III collagen can promote the healing process of the wound, provide a scaffold for new cells, guide cell migration and tissue regeneration, and help the skin recover health faster. Blueberry fruit extract contains rich antioxidants, which can effectively remove free radicals in the skin, protect the structural integrity of collagen and elastin, and thus delay skin aging and wrinkle formation. Saffron flower extract has an anti-inflammatory effect, which can inhibit the activity of inflammatory cells and reduce the production of inflammatory cytokines; it can also regulate the function of nerve endings in the skin, and has a certain alleviating effect on some discomfort symptoms such as skin itching caused by nerve sensitivity. 7-fold hyaluronic acid contains hyaluronic acid of different molecular weights. The large molecule hyaluronic acid can form a breathable protective film on the skin surface to prevent water evaporation and lock in moisture. The small molecule hyaluronic acid can penetrate deep into the skin to replenish moisture and keep the skin moisturized from the inside out. It can fill the gaps between skin cells and make the skin surface smoother and flatter. Due to its good moisturizing properties, it can relieve discomfort symptoms such as tightness and itching caused by dry skin.

[0015] In the soothing and anti-wrinkle combination of the present invention, the various components work together and promote each other, and work together on the skin from multiple aspects such as cell repair, collagen synthesis, structural support, moisturizing and nourishing, forming a comprehensive and effective skin care mechanism, providing the skin with a comprehensive solution for soothing and anti-wrinkle, and helping the skin to restore a healthy and youthful state.

[0016] The present invention also provides a method for preparing the above-mentioned soothing and anti-wrinkle composition, comprising the following steps: (1) Add water into a container, then add supramolecular blue copper peptide, type 17 collagen, type III collagen, blueberry fruit extract, saffron flower extract, multiple hyaluronic acids and alcohol solvent into the container, and stir evenly until there are no particles; (2) The material in the container is transferred into an ultrasonic equipment pot, subjected to ultrasonic treatment, and then filtered to obtain a soothing and anti-wrinkle composition.

[0017] Furthermore, in step (1), water is added to a container, stirred and heated to 80-90°C, kept warm for 15-25 minutes, and then cooled to 25-45°C; The present invention also provides an application of the soothing and anti-wrinkle composition, wherein the soothing and anti-wrinkle composition is applied to skin care products, and the skin care products are face creams, lotions, facial masks or essences; the mass percentage of the soothing and anti-wrinkle composition added to the skin care products is 5-10%.

[0018] Another object of the present invention is to provide a soothing and anti-wrinkle essence, which comprises the soothing and anti-wrinkle composition.

[0019] Furthermore, the soothing and anti-wrinkle essence comprises the following raw materials in percentage by weight: 1-3% of glycerol polyether, 1-3% of glycerol, 0.4-0.6% of trehalose, 0.1-0.3% of panthenol, 0.4-0.6% of p-hydroxyacetophenone, 0.4-0.6% of 1,2-hexanediol, 2-4% of butylene glycol, 5% of the soothing and anti-wrinkle composition, and the balance of water.

[0020] The present invention also provides a method for preparing the soothing and anti-wrinkle essence, comprising the following steps: (B1) mixing glycerol polyether, glycerol, trehalose, panthenol and water, heating to 80-90° C., and homogenizing until the mixture is uniform and free of particles to obtain a first mixed solution; (B2) mixing p-hydroxyacetophenone, 1,2-hexanediol and butanediol, heating to 70° C., and mixing evenly to obtain a second mixed solution; (B3) adding the second mixed solution to the first mixed solution cooled to 55-65° C., mixing well, and obtaining a third mixed solution; (B4) The third mixed solution is cooled to below 40° C., and then the soothing and anti-wrinkle combination phase C is added and mixed evenly to obtain a soothing and anti-wrinkle essence.

[0021] The beneficial effects of the present invention are as follows: the soothing and anti-wrinkle composition of the present invention is organically combined with supramolecular blue copper peptide, type 17 collagen, type III collagen, blueberry fruit extract, saffron flower extract, multiple hyaluronic acids and solvents to give full play to the synergistic effect of each raw material, so that the composition has good soothing and anti-wrinkle effects, stability and applicability. The preparation method of the soothing and anti-wrinkle composition is simple and efficient, easy to operate and control, and conducive to industrial production. The soothing and anti-wrinkle essence of the present invention adopts the soothing and anti-wrinkle composition, has good soothing and anti-wrinkle effects, and provides consumers with an efficient, convenient and safe skin care product. DETAILED DESCRIPTION

[0022] In order to facilitate the understanding of those skilled in the art, the present invention is further described below in conjunction with embodiments, and the contents mentioned in the implementation modes are not intended to limit the present invention.

[0023] In some embodiments of the present invention, a soothing and anti-wrinkle composition comprises the following raw materials in percentage by weight: 1-5% supramolecular blue copper peptide solution, 0.01-0.2% type 17 collagen solution, 0.05-10% type III collagen, 0.04-0.3% blueberry fruit extract, 0.06-1.5% saffron flower extract, 1-10% multiple hyaluronic acid, and the remainder solvent.

[0024] The present invention helps to enhance the skin's repair and regeneration ability, and improve skin firmness and elasticity through the synergistic effect of supramolecular blue copper peptide and bicollagen. The synergistic effect between the raw materials of the present invention helps to moisturize the skin, improve anti-oxidation and skin anti-aging properties, soothe the skin and enhance skin tolerance. According to the different needs and physiological characteristics of the skin during the day and at night, the present invention designs a full-day skin care mechanism. During the day, it focuses on protecting and maintaining the skin condition, and responds to the external environment through anti-oxidation, moisturizing and enhancing the stability of the skin structure; at night, it focuses on in-depth repair and regeneration, and uses the synergistic effect of various ingredients to promote the repair of skin cells and the synthesis of collagen, providing good night care for the skin, which can better meet the needs of the skin at different time periods, and achieve continuous improvement and long-term care of the skin, which has obvious advantages over existing products.

[0025] In some embodiments of the present invention, the type 17 collagen solution comprises the following raw materials in percentage by mass: 45-55% glycerol, 13-19% butylene glycol, 0.03-0.07% soluble collagen, and 30-36% water.

[0026] In some embodiments of the present invention, the supramolecular blue copper peptide solution includes the following raw materials in mass percentage: 2-4% tripeptide-1 copper, 8-12% hydroxyethylpiperazineethane sulfonic acid, 2-3% betaine, 6-9% 1,3-propylene glycol, 69-75% water, and 4-6% 1,2-pentanediol. The supramolecular blue copper peptide is encapsulated by a supramolecular solvent to protect the activity of the blue copper peptide, and the skin penetration of the blue copper peptide can be promoted based on the amphiphilicity of the supramolecular. The preparation of the supramolecular blue copper peptide solution can refer to the blue copper peptide solution with a penetration-promoting system disclosed in the Chinese invention patent with publication number CN114983856A, and its preparation method and application.

[0027] In some embodiments of the present invention, the multiple hyaluronic acid includes the following raw materials in mass percentage: sodium hyaluronate cross-linked polymer 2-3%, sodium hyaluronate 2-3%, hydrolyzed sodium hyaluronate 0.2-0.4%, hyaluronic acid 0.03-0.07%, hydrolyzed hyaluronic acid 0.03-0.07%, acetylated sodium hyaluronate 0.1-0.3%, hydroxypropyl trimethyl ammonium chloride hyaluronic acid 0.03-0.07%, hydrolyzed glycosaminoglycan 0.05-0.15%, 1,2-hexanediol 0.2-0.4%, 1,3-propylene glycol 0.4-0.9%, caprylhydroxamic acid 0.03-0.07%, water 90-95%. The multiple hyaluronic acid is 7-fold hyaluronic acid. The molecular weight control of the hyaluronic acid can refer to the Chinese invention patent of a recombinant Corynebacterium glutamicum expressing hyaluronidase and its application thereof, which is disclosed in CN108251346A.

[0028] In some embodiments of the present invention, the method for preparing the multiple hyaluronic acid comprises the following steps: (A1) adding water to a container, stirring and adding sodium hyaluronate cross-linked polymer, sodium hyaluronate, hydrolyzed sodium hyaluronate, hyaluronic acid, hydrolyzed hyaluronic acid, acetylated sodium hyaluronate, hydroxypropyltrimethylammonium chloride hyaluronic acid, and hydrolyzed glycosaminoglycan, stirring evenly, raising the temperature to 75-80° C., and stirring at a constant temperature until completely dissolved to obtain a mixture A1; (A2) cooling the mixture A1 to 40-45° C., adding 1,2-hexanediol, 1,3-propylene glycol and octanoylhydroxamic acid, and stirring until the mixture becomes transparent and free of impurities, to obtain a mixture A2; (A3) Cooling the mixture A2 to 35-38° C. and then filtering the mixture to obtain a multiple hyaluronic acid complex.

[0029] In some embodiments of the present invention, the solvent is at least one of ionized water and an alcohol solvent; the alcohol solvent is at least one of 1,3-propylene glycol, butylene glycol, dipropylene glycol, 1,2-hexanediol and glycerol.

[0030] Furthermore, the solvent comprises the following raw materials in percentage by mass: 3-6% glycerol, 1-3% 1,2-hexanediol, and the balance water.

[0031] The present invention also provides a method for preparing the above-mentioned soothing and anti-wrinkle composition, comprising the following steps: (1) Add water into a container, then add supramolecular blue copper peptide, type 17 collagen, type III collagen, blueberry fruit extract, saffron flower extract, multiple hyaluronic acids and alcohol solvent into the container, and stir evenly until there are no particles; (2) Transferring the material in the container into the pot of an ultrasonic device, transferring the material in the stirring pot into the pot of an ultrasonic device, performing ultrasonic treatment for 10-30 min at an ultrasonic frequency of 20-40 kHz, filtering the material through a 400 mesh filter to obtain a soothing and anti-wrinkle composition.

[0032] Furthermore, in step (1), water is added to a container, stirred and heated to 80-90°C, kept warm for 15-25 minutes, and then cooled to 25-45°C; The present invention also provides an application of the soothing and anti-wrinkle composition, wherein the soothing and anti-wrinkle composition is applied to skin care products, and the skin care products are face creams, lotions, facial masks or essences; the mass percentage of the soothing and anti-wrinkle composition added to the skin care products is 5-10%.

[0033] Another object of the present invention is to provide a soothing and anti-wrinkle essence, which comprises the soothing and anti-wrinkle composition.

[0034] Furthermore, the soothing and anti-wrinkle essence comprises the following raw materials in percentage by weight: 1-3% of glycerol polyether, 1-3% of glycerol, 0.4-0.6% of trehalose, 0.1-0.3% of panthenol, 0.4-0.6% of p-hydroxyacetophenone, 0.4-0.6% of 1,2-hexanediol, 2-4% of butylene glycol, 5% of the soothing and anti-wrinkle composition, and the balance of water.

[0035] The present invention also provides a method for preparing the soothing and anti-wrinkle essence, comprising the following steps: (B1) mixing glycerol polyether, glycerol, trehalose, panthenol and water, heating to 80-90° C., and homogenizing until the mixture is uniform and free of particles to obtain a first mixed solution; (B2) mixing p-hydroxyacetophenone, 1,2-hexanediol and butanediol, heating to 70° C., and mixing evenly to obtain a second mixed solution; (B3) adding the second mixed solution to the first mixed solution cooled to 55-65° C., mixing well, and obtaining a third mixed solution; (B4) The third mixed solution is cooled to below 40° C., and then the soothing and anti-wrinkle combination phase C is added and mixed evenly to obtain a soothing and anti-wrinkle essence.

[0036] Example 1 In this embodiment, a soothing and anti-wrinkle composition includes the following raw materials in percentage by weight: 2% supramolecular blue copper peptide solution, 0.06% type 17 collagen solution, 3% type III collagen, 0.09% blueberry fruit extract, 0.4% saffron flower extract, 3% multiple hyaluronic acid, 5% glycerol, 2% 1,2-hexanediol, and the balance water.

[0037] Furthermore, the type 17 collagen solution includes the following raw materials in percentage by mass: 50% glycerol, 16% butylene glycol, 0.05% soluble collagen, and 33.95% water.

[0038] Furthermore, the supramolecular blue copper peptide solution includes the following raw materials in percentage by weight: 3% tripeptide-1 copper, 10% hydroxyethylpiperazineethane sulfonic acid, 2.4% betaine, 7.6% 1,3-propylene glycol, 72% water, and 5% 1,2-pentanediol.

[0039] Further, the multiple hyaluronic acid comprises the following raw materials in percentage by weight: 2.5% sodium hyaluronate cross-linked polymer, 2.5% sodium hyaluronate, 0.3% hydrolyzed sodium hyaluronate, 0.05% hyaluronic acid, 0.05% hydrolyzed hyaluronic acid, 0.2% acetylated sodium hyaluronate, 0.05% hydroxypropyltrimethylammonium chloride hyaluronic acid, 0.1% hydrolyzed glycosaminoglycan, 0.3% 1,2-hexanediol, 0.65% 1,3-propylene glycol, 0.05% caprylhydroxamic acid, and 93.25% water. The water used in this embodiment is deionized water, and the multiple hyaluronic acid is seven-fold hyaluronic acid.

[0040] The preparation method of the multiple hyaluronic acid comprises the following steps: (A1) Add water to a clean and disinfected emulsifying pot, start stirring at a speed of 20 rpm, then add sodium hyaluronate cross-linked polymer, sodium hyaluronate, hydrolyzed sodium hyaluronate, hyaluronic acid, hydrolyzed hyaluronic acid, acetylated sodium hyaluronate, hydroxypropyltrimethylammonium chloride hyaluronic acid, and hydrolyzed glycosaminoglycan in sequence, stir evenly, heat to 78° C., and stir at a constant temperature for 15 min until completely dissolved and transparent without fine particles, to obtain a mixture A1; (A2) Cooling the mixture A1 to 42° C., adding 1,2-hexanediol, 1,3-propylene glycol and octanoylhydroxamic acid, and stirring for 15 minutes until the mixture becomes transparent and free of impurities, to obtain a mixture A2; (A3) The mixture A2 is cooled to 37° C., and then filtered using a 200-mesh filter to obtain a multiple hyaluronic acid composite.

[0041] In this embodiment, a method for preparing the above-mentioned soothing and anti-wrinkle composition comprises the following steps: (1) Add water into a stirring pot, then add supramolecular blue copper peptide, type 17 collagen, type III collagen, blueberry fruit extract, saffron flower extract, multiple hyaluronic acids and alcohol solvent into the stirring pot, and stir evenly until there are no particles; (2) The material in the stirring pot is transferred into the pot of an ultrasonic device and ultrasonically treated for 10 minutes at an ultrasonic frequency of 40 kHz. The material is then filtered through a 400-mesh filter to obtain a soothing and anti-wrinkle composition.

[0042] Furthermore, in step (1), water is added to a stirring pot, stirred and heated to 90°C, kept at this temperature for 20 minutes, and then cooled to 30°C; This embodiment also provides a soothing and anti-wrinkle essence, which includes the following raw materials in percentage by mass: 2% of glycerol polyether-26, 2% of glycerol, 0.5% of trehalose, 0.2% of panthenol, 0.5% of p-hydroxyacetophenone, 0.5% of 1,2-hexanediol, 3% of butylene glycol, 5% of the soothing and anti-wrinkle composition of this embodiment, and the balance of water. In this embodiment, the combination of glycerol polyether, glycerol, trehalose and panthenol is used as phase A; the combination of p-hydroxyacetophenone, 1,2-hexanediol and butylene glycol is used as phase B; and the soothing and anti-wrinkle composition is used as phase C.

[0043] In this embodiment, a method for preparing the above-mentioned soothing and anti-wrinkle essence comprises the following steps: (B1) mixing glycerol polyether, glycerol, trehalose, panthenol and water, heating to 85° C., and homogenizing for 3 minutes until the mixture is uniform and free of particles, to obtain a first mixed solution; (B2) mixing p-hydroxyacetophenone, 1,2-hexanediol and butanediol, heating to 70° C., and mixing evenly to obtain a second mixed solution; (B3) adding the second mixed solution to the first mixed solution cooled to 60° C., mixing well, and obtaining a third mixed solution; (B4) The third mixed solution is cooled to below 40° C., and then the soothing and anti-wrinkle combination phase C is added and mixed evenly to obtain a soothing and anti-wrinkle essence.

[0044] Example 2 In this embodiment, a soothing and anti-wrinkle composition includes the following raw materials in percentage by weight: 3% supramolecular blue copper peptide solution, 0.12% type 17 collagen solution, 6% type III collagen, 0.18% blueberry fruit extract, 0.8% saffron flower extract, 6% multiple hyaluronic acid, 5% glycerol, 2% 1,2-hexanediol, and the balance water.

[0045] The present embodiment also provides a soothing and anti-wrinkle essence, which comprises the following raw materials in percentage by mass: 2% of glyceryl polyether-26, 2% of glycerol, 0.5% of trehalose, 0.2% of panthenol, 0.5% of p-hydroxyacetophenone, 0.5% of 1,2-hexanediol, 3% of butylene glycol, 5% of the soothing and anti-wrinkle composition of the present embodiment, and the balance of water.

[0046] The rest of the content of this embodiment is the same as that of Embodiment 1 and will not be repeated here.

[0047] Example 3 In this embodiment, a soothing and anti-wrinkle composition includes the following raw materials in percentage by weight: 4% supramolecular blue copper peptide solution, 0.18% type 17 collagen solution, 9% type III collagen, 0.27% blueberry fruit extract, 1.2% saffron flower extract, 9% multiple hyaluronic acid, 5% glycerol, 2% 1,2-hexanediol, and the balance water.

[0048] The present embodiment also provides a soothing and anti-wrinkle essence, which comprises the following raw materials in percentage by mass: 2% of glyceryl polyether-26, 2% of glycerol, 0.5% of trehalose, 0.2% of panthenol, 0.5% of p-hydroxyacetophenone, 0.5% of 1,2-hexanediol, 3% of butylene glycol, 5% of the soothing and anti-wrinkle composition of the present embodiment, and the balance of water.

[0049] The rest of the content of this embodiment is the same as that of Embodiment 1 and will not be repeated here.

[0050] Comparative Example 1 In this comparative example, a soothing and anti-wrinkle composition includes the following raw materials in percentage by weight: 0.12% type 17 collagen solution, 3% type III collagen, 0.18% blueberry fruit extract, 1.2% saffron flower extract, 9% multiple hyaluronic acid, 5% glycerol, 2% 1,2-hexanediol, and the balance water.

[0051] This comparative example also provides a soothing and anti-wrinkle essence, which comprises the following raw materials in percentage by mass: 2% of glyceryl polyether-26, 2% of glycerol, 0.5% of trehalose, 0.2% of panthenol, 0.5% of p-hydroxyacetophenone, 0.5% of 1,2-hexanediol, 3% of butylene glycol, 5% of the soothing and anti-wrinkle composition of this comparative example, and the balance of water.

[0052] The rest of the contents of this comparative example are the same as those of Example 1 and will not be described again here.

[0053] Comparative Example 2 In this comparative example, a soothing and anti-wrinkle composition comprises the following raw materials in percentage by weight: 3% supramolecular blue copper peptide solution, 6% type III collagen, 0.27% blueberry fruit extract, 0.8% saffron flower extract, 6% multiple hyaluronic acid, 5% glycerol, 2% 1,2-hexanediol, and the balance water.

[0054] This comparative example also provides a soothing and anti-wrinkle essence, which comprises the following raw materials in percentage by mass: 2% of glyceryl polyether-26, 2% of glycerol, 0.5% of trehalose, 0.2% of panthenol, 0.5% of p-hydroxyacetophenone, 0.5% of 1,2-hexanediol, 3% of butylene glycol, 5% of the soothing and anti-wrinkle composition of this comparative example, and the balance of water.

[0055] The rest of the contents of this comparative example are the same as those of Example 1 and will not be described again here.

[0056] Comparative Example 3 In this comparative example, a soothing and anti-wrinkle composition comprises the following raw materials in percentage by weight: 4% supramolecular blue copper peptide solution, 0.06% type 17 collagen solution, 0.09% blueberry fruit extract, 0.4% saffron flower extract, 3% multiple hyaluronic acid, 5% glycerol, 2% 1,2-hexanediol, and the balance water.

[0057] This comparative example also provides a soothing and anti-wrinkle essence, which comprises the following raw materials in percentage by mass: 2% of glyceryl polyether-26, 2% of glycerol, 0.5% of trehalose, 0.2% of panthenol, 0.5% of p-hydroxyacetophenone, 0.5% of 1,2-hexanediol, 3% of butylene glycol, 5% of the soothing and anti-wrinkle composition of this comparative example, and the balance of water.

[0058] The rest of the contents of this comparative example are the same as those of Example 1 and will not be described again here.

[0059] The mass percentage of each raw material in the soothing and anti-wrinkle composition prepared in Examples 1-3 and Comparative Examples 1-3 is shown in Table 1 below: Table 1 The dosage ratio of each raw material in the soothing and anti-wrinkle composition

[0060] The soothing and anti-wrinkle combination liquids in Examples 1-3 and Comparative Examples 1-3 were added to the essence liquid system, and the mass percentages of the raw materials in the soothing and anti-wrinkle essence liquids were as shown in Table 2 below: Table 2 The dosage ratio of each raw material in the soothing anti-wrinkle essence

[0061] The soothing and anti-wrinkle essences prepared in Examples 1-3 and Comparative Examples 1-3, respectively, and the soothing and anti-wrinkle essences without adding the soothing and anti-wrinkle composition were tested in vitro. The test methods and results are as follows: 1. Firming effect test Experimental purpose: To investigate the inhibitory effect of the soothing and anti-wrinkle composition on elastase.

[0062] Experimental principle: Elastic fibers are composed of elastin and microfibrils, distributed in the dermis and subcutaneous tissue, making the skin elastic. However, due to the effects of some environmental factors such as ultraviolet radiation, pressure, pollution, etc., the production of elastase in the body will be promoted. Elastase is a member of the chymosin family, which will degrade elastin, causing the loss of connecting tissue in the epidermis, leading to skin aging, wrinkles and photoaging. Studies have shown that inhibiting elastase from decomposing elastin can have a firming effect, so the elastin inhibition rate can reflect the anti-aging performance of the product. Through experimental design, the test samples are compared with the blank control group for the results of the elastase inhibition rate test. If the inhibition rate of the test sample is better than (higher than) the inhibition rate of the blank control group and the statistical difference P value is <0.05, it can be considered that the test sample has a certain firming effect.

[0063] Experimental method: Add appropriate amount of buffer solution, sample diluent of different concentrations and substrate to the 96-well plate, shake and mix, incubate for 20 minutes, then add elastase solution, shake and incubate for 10 minutes immediately, measure the absorbance at 410nm with an enzyme reader, analyze and process the data to calculate the inhibition rate of the sample to be tested on elastase. The calculation formula is as follows: Elastase inhibition (%) = [1-(AB) / (CD)]*100% Where: A is the absorbance of the experimental group; B is the absorbance of the experimental blank group; C is the absorbance of the control group; D is the absorbance of the blank group.

[0064] The specific test results are shown in Table 3 below: Table 3

[0065] From Table 3, it can be seen that the soothing and anti-wrinkle composition of Examples 1-3 has a better inhibition rate on elastase than Comparative Examples 1-3; from the above content, it can be seen that the combination of supramolecular blue copper peptide, type 17 collagen, type III collagen, blueberry fruit extract, saffron flower extract, and 7-fold hyaluronic acid has a synergistic effect.

[0066] 2. Soothing effect test Experimental purpose: To investigate the inhibitory effect of the soothing and anti-wrinkle composition on hyaluronidase.

[0067] Experimental principle: Soothing means helping to improve skin irritation and other conditions. Relevant literature shows that hyaluronic acid is widely present in the skin and other tissues, and the relationship between hyaluronic acid and the skin is very close. Macromolecular hyaluronic acid can inhibit inflammatory reactions, thereby alleviating the discomfort caused by skin inflammation. Macromolecular hyaluronic acid will be degraded under the action of hyaluronidase, resulting in a decrease in the content of macromolecular hyaluronic acid. The decomposition produces a degradation product, N-acetylglucosamine. Determining the content of N-acetylglucosamine in the reaction system can indirectly reflect the activity of hyaluronidase.

[0068] Relevance of test method: This method is an in vitro method and is applicable to cosmetics that claim soothing effects. In this experiment, the test sample is added to determine the inhibition rate of the test sample on hyaluronidase by measuring the N-acetylglucosamine content in the reaction system. Through the experimental design, the test sample and the blank control group are compared for the hyaluronidase inhibition test results. If the inhibition rate of the test sample group is better (higher) than that of the blank control group, and the statistical difference P value is <0.05, then the test sample can be considered to have a soothing effect.

[0069] Test indicators: The hyaluronidase inhibition rate of the test sample group is better (higher) than that of the blank control group, and the statistical difference P value of the hyaluronidase inhibition rate is <0.05, indicating that the test sample has a soothing effect.

[0070] The specific test results are shown in Table 4 below: Table 4

[0071] From Table 4, it can be seen that the soothing and anti-wrinkle compositions of Examples 1-3 have a better inhibition rate on hyaluronidase than Comparative Examples 1-3; from the above content, it can be seen that the combination of supramolecular blue copper peptide, type 17 collagen, type III collagen, blueberry fruit extract, saffron flower extract, and multiple hyaluronic acid has a synergistic effect.

[0072] In summary, combined with the test results in Tables 3-4, it can be concluded that the soothing and anti-wrinkle composition of the present invention can be used in skin care products to synergistically improve the soothing and anti-wrinkle effects.

[0073] The above embodiments are preferred implementation schemes of the present invention. In addition, the present invention may also be implemented in other ways. Any obvious replacement without departing from the concept of the present invention is within the protection scope of the present invention.

Claims

1. A soothing and anti-wrinkle composition, characterized in that: The invention comprises the following raw materials in percentage by weight: 1-5% of supramolecular blue copper peptide solution, 0.01-0.2% of type 17 collagen solution, 0.05-10% of type III collagen, 0.04-0.3% of blueberry fruit extract, 0.06-1.5% of saffron flower extract, 1-10% of multiple hyaluronic acid and the remainder of solvent.

2. The soothing and anti-wrinkle composition according to claim 1, characterized in that: The type 17 collagen solution comprises the following raw materials in percentage by mass: 45-55% glycerol, 13-19% butanediol, 0.03-0.07% soluble collagen, and 30-36% water.

3. The soothing and anti-wrinkle composition according to claim 1, characterized in that: The supramolecular blue copper peptide solution comprises the following raw materials in percentage by weight: 2-4% of tripeptide-1 copper, 8-12% of hydroxyethylpiperazineethane sulfonic acid, 2-3% of betaine, 6-9% of 1,3-propylene glycol, 69-75% of water, and 4-6% of 1,2-pentanediol.

4. The soothing and anti-wrinkle composition according to claim 1, characterized in that: The multiple hyaluronic acid comprises the following raw materials in percentage by weight: 2-3% sodium hyaluronate cross-linked polymer, 2-3% sodium hyaluronate, 0.2-0.4% hydrolyzed sodium hyaluronate, 0.03-0.07% hyaluronic acid, 0.03-0.07% hydrolyzed hyaluronic acid, 0.1-0.3% acetylated sodium hyaluronate, 0.03-0.07% hydroxypropyltrimethylammonium chloride hyaluronic acid, 0.05-0.15% hydrolyzed glycosaminoglycan, 0.2-0.4% 1,2-hexanediol, 0.4-0.9% 1,3-propylene glycol, 0.03-0.07% caprylhydroxamic acid, and 90-95% water.

5. The soothing and anti-wrinkle composition according to claim 1, characterized in that: The solvent is at least one of ionized water and alcohol solvents; the alcohol solvent is at least one of 1,3-propylene glycol, butylene glycol, dipropylene glycol, 1,2-hexanediol and glycerol.

6. A method for preparing the soothing and anti-wrinkle composition according to any one of claims 1 to 5, characterized in that: The steps include: (1) Add water into a container, then add supramolecular blue copper peptide, type 17 collagen, type III collagen, blueberry fruit extract, saffron flower extract, multiple hyaluronic acids and alcohol solvent into the container, and stir evenly until there are no particles; (2) The material in the container is transferred into an ultrasonic equipment pot, subjected to ultrasonic treatment, and then filtered to obtain a soothing and anti-wrinkle composition.

7. An application of the soothing and anti-wrinkle composition according to any one of claims 1 to 5, characterized in that: The soothing and anti-wrinkle composition is applied to skin care products, and the mass percentage of the soothing and anti-wrinkle composition added in the skin care products is 5-10%.

8. A soothing and anti-wrinkle essence, characterized by: The soothing and anti-wrinkle composition comprises the soothing and anti-wrinkle composition according to any one of claims 1 to 5.

9. The soothing and anti-wrinkle essence according to claim 8, characterized in that: The invention comprises the following raw materials in percentage by weight: 1-3% of glycerol polyether, 1-3% of glycerol, 0.4-0.6% of trehalose, 0.1-0.3% of panthenol, 0.4-0.6% of p-hydroxyacetophenone, 0.4-0.6% of 1,2-hexanediol, 2-4% of butylene glycol, 5% of soothing and anti-wrinkle composition, and the balance of water.

10. A method for preparing the soothing and anti-wrinkle essence according to claim 8, characterized in that: The steps include: (B1) mixing glycerol polyether, glycerol, trehalose, panthenol and water, heating to 80-90° C., and homogenizing until the mixture is uniform and free of particles to obtain a first mixed solution; (B2) mixing p-hydroxyacetophenone, 1,2-hexanediol and butanediol, heating to 70° C., and mixing evenly to obtain a second mixed solution; (B3) adding the second mixed solution to the first mixed solution cooled to 55-65° C., mixing well, and obtaining a third mixed solution; (B4) Cooling the third mixed solution, then adding the soothing and anti-wrinkle combination and mixing evenly to obtain a soothing and anti-wrinkle essence.

Images