External liniment for treating tinea pedis and onychomycosis

Abstract

The invention discloses an external liniment for treating tinea pedis and onychomycosis, which belongs to the technical field of fungal infection treatment, and is prepared from the following components in parts by weight: 5-15 parts of traditional Chinese medicine component, 2-20 parts of western medicine component, 10-20 parts of adjuvant and 30-50 parts of water, the traditional Chinese medicine component is prepared from the following components in parts by weight: 2 to 15 parts of radix sophorae flavescentis, 3 to 20 parts of cortex dictamni, 2 to 15 parts of herba artemisiae annuae and 1 to 10 parts of radix saposhnikoviae; the western medicine component is sodium salicylate; the auxiliary agent is edible white vinegar. When the liniment is used for treating tinea pedis and onychomycosis, only the liniment needs to be smeared on an affected part during use, the liniment is simple and convenient to use and high in safety, starch traditional Chinese medicine components such as radix sophorae flavescentis and the like are adopted as traditional medicinal materials and are mild, antifungal, anti-inflammatory and free of human body functions, western medicine sodium salicylate is reasonably coordinated, and through compatibility of an auxiliary agent edible white vinegar, the liniment can be used for treating tinea pedis and onychomycosis. The traditional Chinese medicine composition has no health hidden danger after long-term use, has no pollution to the environment and is a high-quality scheme for treating fungal dermatosis.

Description

Technical Field

[0001] The invention belongs to the technical field of fungal infection treatment, and in particular relates to an external liniment for treating tinea pedis and onychomycosis. Background Art

[0002] Tinea pedis is a very common fungal skin disease caused by dermatophytes infecting the skin of the feet. In daily life, the feet are often in a relatively closed, humid and warm environment, such as wearing airtight shoes and socks for a long time, which creates excellent conditions for the growth and reproduction of fungi. Its symptoms are diverse, and the common ones are whitening and erosion of the skin between the toes, blisters and peeling on the soles of the feet, dry and cracked heels, and unbearable itching, etc., which not only bring physical discomfort to patients, but also seriously affect the quality of life of patients due to frequent attacks. In addition, tinea pedis is highly contagious and can be easily spread among family members or in public places through sharing slippers, foot basins and other items. In addition, onychomycosis, as another disease caused by fungal infection of nails and nail beds, is usually related to tinea pedis and is a source of infection for each other, making the disease more stubborn and difficult to cure. Traditional treatment methods have many disadvantages. Some topical drugs have short-term efficacy and are difficult to completely eradicate fungi. Although oral antifungal drugs have certain effects, they may be accompanied by certain side effects and cause potential burdens on organs such as the liver. Therefore, there is an urgent need for an efficient, safe and easy-to-use therapeutic drug. Summary of the invention

[0003] In view of the above situation, in order to overcome the defects of the prior art, the external ointment disclosed in the present invention can effectively treat tinea pedis and onychomycosis by combining various components.

[0004] In order to achieve the above-mentioned purpose, the following technical scheme is adopted: the present invention provides an external ointment for treating tinea pedis and onychomycosis, which is made of the following components in parts by weight: 5-15 parts of traditional Chinese medicine components, 2-20 parts of western medicine components, 10-20 parts of adjuvants and 30-50 parts of water; the traditional Chinese medicine components include the following components in parts by weight: 2-15 parts of Sophora flavescens, 3-20 parts of Dictamni cortex, 2-15 parts of Artemisia annua and 1-10 parts of Saposhnikovia divaricata; the western medicine component is sodium salicylate; and the adjuvant is edible white vinegar.

[0005] Sophora flavescens: It has the effects of clearing away heat and dampness, killing insects and acting as a diuretic. The various alkaloid components it contains, such as matrine, have a significant inhibitory effect on skin fungi, can penetrate deep into the bottom layer of the skin, remove hidden fungi, and relieve the itching, scaling and other discomforts caused by fungal infections such as tinea pedis and onychomycosis.

[0006] Dictamni: It is bitter and cold in nature, and has the effects of clearing away heat and dampness, dispelling wind and detoxifying. It can effectively remove wind evil and dampness on the surface of the skin. The ingredients such as dicumarine and phellodendron not only have antibacterial and anti-inflammatory effects, but also promote the repair of damaged skin, enhance the skin's own resistance, and create a good skin environment for the treatment of tinea pedis and onychomycosis.

[0007] Artemisia annua: It can clear away heat, eliminate bone steaming, relieve summer heat, stop malaria, and reduce jaundice. Its volatile oil and artemisinin and other substances have high antifungal ability, can quickly penetrate into the stratum corneum of nails and foot skin, inhibit fungal growth and reproduction, and at the same time reduce local inflammatory reactions caused by fungi, relieving redness, swelling, heat and pain.

[0008] Saposhnikovia divaricata: It has the effects of dispelling wind and relieving exterior symptoms, relieving dampness and relieving pain, and stopping spasms. In this ointment, Saposhnikovia divaricata, on the one hand, helps other herbs dispel wind evil on the skin surface and improves the unbearable itching caused by fungal infection; on the other hand, the volatile oils and other ingredients it contains can regulate the circulation of qi and blood in the skin, which is beneficial to the overall effect of the medicine and promotes the skin to return to a healthy state.

[0009] Sodium salicylate: As a western medicine ingredient, it has a strong keratin-dissolving effect and can soften the stratum corneum thickened due to tinea pedis and onychomycosis, making it easier for the drug to penetrate deep into the lesions and directly act on pathogenic fungi, thereby improving the therapeutic effect. At the same time, it also has certain anti-inflammatory properties to help reduce local inflammation.

[0010] Edible white vinegar: As an auxiliary agent, the acetic acid component can adjust the pH of the ointment, create an acidic environment that is not conducive to the survival of fungi, and inhibit fungal growth. In addition, edible white vinegar itself has a certain bactericidal effect, which can help enhance the antibacterial ability of the entire formula, soften the cuticle, and help other effective ingredients to penetrate and absorb better, synergistically playing a role in treating tinea pedis and onychomycosis.

[0011] Preferably, the external ointment is made of the following components in parts by weight: 6-12 parts of traditional Chinese medicine components, 5-15 parts of western medicine components, 12-18 parts of adjuvants and 35-45 parts of water; the traditional Chinese medicine components include the following components in parts by weight: 5-12 parts of Sophora flavescens, 5-18 parts of Dictamni cortex, 3-12 parts of Artemisia annua and 2-8 parts of Saposhnikovia divaricata; the western medicine component is sodium salicylate; and the adjuvant is edible white vinegar.

[0012] Preferably, the external ointment is made of the following components in parts by weight: 8-10 parts of traditional Chinese medicine components, 6-10 parts of western medicine components, 13-15 parts of adjuvants and 36-42 parts of water; the traditional Chinese medicine components include the following components in parts by weight: 6-10 parts of Sophora flavescens, 6-15 parts of Dictamni cortex, 4-10 parts of Artemisia annua and 3-6 parts of Saposhnikovia divaricata; the western medicine component is sodium salicylate; and the adjuvant is edible white vinegar.

[0013] As the most preferred, the external ointment is made of the following components in parts by weight: 9 parts of traditional Chinese medicine components, 7 parts of western medicine components, 14 parts of adjuvants and 38 parts of water; the traditional Chinese medicine components include the following components in parts by weight: 7 parts of Sophora flavescens, 8 parts of Dictamni cortex, 6 parts of Artemisia annua and 5 parts of Saposhnikovia divaricata; the western medicine component is sodium salicylate; and the adjuvant is edible white vinegar.

[0014] Furthermore, the external liniment is prepared by the following steps:

[0015] Sophora flavescens, Dictamni cortex, Artemisia annua and Saposhnikovia divaricata are washed and dried, added to water with a mass 15 times that of the traditional Chinese medicine components, and boiled for 30 minutes, then filtered, and the filtered medicinal residues are added to water with a mass 10 times that of the medicinal residues and continued to boil for 30 minutes, and then filtered for a second time, and the two filtrates are combined, dehydrated under reduced pressure, and dried in a dryer until the moisture content is less than 2.5%, and then ground with a grinder, and then mixed with sodium salicylate and water to obtain the external ointment.

[0016] Furthermore, the drying temperature of the dryer is 60-70°C.

[0017] Furthermore, the fineness of the Chinese medicinal raw materials after grinding is 100-150 mesh.

[0018] Furthermore, when the ointment is used to treat tinea pedis: the external ointment is applied to the skin area affected by tinea pedis, including between the toes, soles, heels and edges of the feet, twice a day, and continued to be used until the skin returns to normal.

[0019] Furthermore, use a nail clipper or file to trim off the thickened part of the surface of the diseased nail, use a clean cotton ball to dip the topical ointment, apply it to the surface of the diseased nail, as well as the edge and root of the nail, apply it twice a day, and continue to use it until the diseased nail returns to normal.

[0020] The beneficial effects of the present invention are as follows: when the present invention is used to treat tinea pedis and onychomycosis, it is only necessary to apply the liniment to the affected area, the use is simple and convenient, and the safety is high; the starch Chinese medicine components such as Sophora flavescens and the like are all traditional medicinal materials, which are mildly anti-fungal and anti-inflammatory and do not damage human body functions; the Western medicine sodium salicylate is reasonably coordinated; through the compatibility of the auxiliary agent edible white vinegar, there is no health hazard in long-term use, and there is no pollution to the environment, and the present invention is a high-quality solution for the treatment of fungal skin diseases. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 The results of the efficacy evaluation of the external liniment in treating tinea pedis according to the embodiments of the present invention are as follows;

[0022] Figure 2 The results are the efficacy evaluation results of the external ointment in treating onychomycosis according to various embodiments of the present invention.

[0023] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used to explain the present invention together with the embodiments of the present invention and do not constitute a limitation of the present invention. DETAILED DESCRIPTION

[0024] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0025] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as those familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to those described herein may be applied to the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only and are not intended to limit the content of this application.

[0026] The experimental methods in the following examples are conventional methods unless otherwise specified, and the experimental materials used in the following examples are purchased from commercial channels unless otherwise specified.

[0027] Example 1

[0028] External liniment for treating tinea pedis and onychomycosis

[0029] The external ointment is made of the following components in parts by weight: 5 parts of traditional Chinese medicine components, 2 parts of western medicine components, 10 parts of adjuvants and 30 parts of water; the traditional Chinese medicine components include the following components in parts by weight: 2 parts of sophora flavescens, 3 parts of licorice root, 2 parts of artemisia annua and 1 part of siler; the western medicine component is sodium salicylate; and the adjuvant is edible white vinegar.

[0030] The external liniment is prepared by the following steps:

[0031] Sophora flavescens, Dictamni cortex, Artemisia annua and Saposhnikovia divaricata are washed and dried, added to water with a mass 15 times that of the traditional Chinese medicine components, and boiled for 30 minutes, then filtered, and the filtered medicinal residues are added to water with a mass 10 times that of the medicinal residues and continued to boil for 30 minutes, and then filtered for a second time, and the two filtrates are combined, decompressed and dehydrated, and placed in a dryer for drying at a drying temperature of 60°C, and dried until the moisture content is less than 2.5%, and then a grinder is used to grind the dried Chinese medicinal raw materials to a fineness of 100 mesh, and then mixed with sodium salicylate and water to obtain the external ointment.

[0032] Example 2

[0033] External liniment for treating tinea pedis and onychomycosis

[0034] The external ointment is made of the following components in parts by weight: 12 parts of traditional Chinese medicine components, 15 parts of western medicine components, 18 parts of adjuvants and 45 parts of water; the traditional Chinese medicine components include the following components in parts by weight: 12 parts of sophora flavescens, 18 parts of licorice root, 12 parts of artemisia annua and 8 parts of siler; the western medicine component is sodium salicylate; and the adjuvant is edible white vinegar.

[0035] The external liniment is prepared by the following steps:

[0036] Sophora flavescens, Dictamni cortex, Artemisia annua and Saposhnikovia divaricata are washed and dried, added to water with a mass 15 times that of the traditional Chinese medicine components, and boiled for 30 minutes, then filtered, and the filtered medicinal residues are added to water with a mass 10 times that of the medicinal residues to continue boiling for 30 minutes, and then filtered for a second time, and the two filtrates are combined, dehydrated under reduced pressure, and dried in a dryer at a drying temperature of 70°C until the moisture content is less than 2.5%, and then ground into a fineness of 150 mesh using a grinder, and then mixed with sodium salicylate and water to obtain the external ointment.

[0037] Example 3

[0038] External liniment for treating tinea pedis and onychomycosis

[0039] The external ointment is made of the following components in parts by weight: 8 parts of traditional Chinese medicine components, 6 parts of western medicine components, 13 parts of adjuvants and 36 parts of water; the traditional Chinese medicine components include the following components in parts by weight: 6 parts of sophora flavescens, 6 parts of licorice root, 4 parts of artemisia annua and 3 parts of siler; the western medicine component is sodium salicylate; and the adjuvant is edible white vinegar.

[0040] The external liniment is prepared by the following steps:

[0041] Sophora flavescens, Dictamni cortex, Artemisia annua and Saposhnikovia divaricata are washed and dried, added to water with a mass 15 times that of the traditional Chinese medicine components, and boiled for 30 minutes, then filtered, and the filtered medicinal residues are added to water with a mass 10 times that of the medicinal residues to continue boiling for 30 minutes, and then filtered for a second time, and the two filtrates are combined, dehydrated under reduced pressure, and dried in a dryer at a drying temperature of 65° C., and dried until the moisture content is less than 2.5%, and then ground into a grinder to a fineness of 120 mesh, and then mixed with sodium salicylate and water to obtain the external ointment.

[0042] Example 4

[0043] External liniment for treating tinea pedis and onychomycosis

[0044] The external ointment is made of the following components in parts by weight: 9 parts of traditional Chinese medicine components, 7 parts of western medicine components, 14 parts of adjuvants and 38 parts of water; the traditional Chinese medicine components include the following components in parts by weight: 7 parts of sophora flavescens, 8 parts of licorice root, 6 parts of artemisia annua and 5 parts of siler; the western medicine component is sodium salicylate; and the adjuvant is edible white vinegar.

[0045] The external liniment is prepared by the following steps:

[0046] Sophora flavescens, Dictamni cortex, Artemisia annua and Saposhnikovia divaricata are washed and dried, added to water with a mass 15 times that of the traditional Chinese medicine components, and boiled for 30 minutes, then filtered, and the filtered medicinal residues are added to water with a mass 10 times that of the medicinal residues to continue boiling for 30 minutes, and then filtered for a second time, and the two filtrates are combined, dehydrated under reduced pressure, and dried in a dryer at a drying temperature of 60°C until the moisture content is less than 2.5%, and then ground into a grinder to a fineness of 120 mesh, and then mixed with sodium salicylate and water to obtain the external ointment.

[0047] Results Analysis

[0048] Test Example 1

[0049] Evaluation of the efficacy of topical liniments in treating tinea pedis

[0050] 80 patients who had not used any antifungal drugs within 3 weeks were selected from the patients with superficial tinea pedis in the dermatology clinic and were divided into 4 groups. After informed consent of the patients, each group was treated with the topical ointment prepared in each embodiment of the present invention for tinea pedis. After 2 weeks, the skin lesion area, blisters, and desquamation were observed. The skin lesion area was scored according to the percentage of the entire foot skin area. If there was no skin lesion, it was scored as 0 points, if the skin lesion area was less than 10%, it was scored as 1 point, if it was 10%-30%, it was scored as 2 points, and if it was greater than 30%, it was scored as 3 points. Blisters and desquamation can also be similarly divided into 0-3 points according to the severity. Then, the efficacy index was calculated according to the following formula:

[0051] Therapeutic index = (total score before treatment - total score after treatment) / total score before treatment × 100%,

[0052] The efficacy index is ≥90%, which means that the symptoms and signs have basically disappeared;

[0053] 60% ≤ efficacy index < 90%, indicating significant improvement in symptoms and signs;

[0054] 30%≤efficacy index<60%, indicating improvement in symptoms and signs;

[0055] The efficacy index is <30%, indicating that there is no significant improvement or aggravation of symptoms and signs.

[0056] The tinea pedis efficacy index of each embodiment is shown in Figure 1 .

[0057] Depend on Figure 1 It can be seen that the efficacy index of the present invention for tinea pedis is higher than 90%, showing an excellent therapeutic effect on tinea pedis and can effectively improve the tinea pedis symptoms of patients.

[0058] Test Example 2

[0059] Evaluation of the efficacy of topical liniments in treating onychomycosis

[0060] 80 patients with superficial onychomycosis in dermatology clinic who had not used any antifungal drugs within 3 weeks were selected and divided into 4 groups. After informed consent of the patients, each group was treated with the external liniment prepared in each embodiment of the present invention for onychomycosis. After 3 months, the degree of involvement, thickening, color change, etc. of the diseased nails were observed. If the diseased nails were not involved, it was recorded as 0 points, the involved area was less than 1 / 3 as 1 point, 1 / 3-2 / 3 as 2 points, and greater than 2 / 3 as 3 points; the nail thickening was not obvious as 0 points, mild thickening as 1 point, moderate thickening as 2 points, and severe thickening as 3 points; the nail color was normal as 0 points, the color was slightly changed as 1 point, the moderate change was recorded as 2 points, and the severe change was recorded as 3 points. Then the efficacy index was calculated according to the following formula:

[0061] Therapeutic index = (total score before treatment - total score after treatment) / total score before treatment × 100%,

[0062] The efficacy index is ≥90%, which means that the symptoms and signs have basically disappeared;

[0063] 60% ≤ efficacy index < 90%, indicating significant improvement in symptoms and signs;

[0064] 30%≤efficacy index<60%, indicating improvement in symptoms and signs;

[0065] The efficacy index is <30%, indicating that there is no significant improvement or aggravation of symptoms and signs.

[0066] The onychomycosis efficacy index of each embodiment is shown in Figure 2 .

[0067] Depend on Figure 2 It can be seen that the therapeutic index of the present invention for onychomycosis is higher than 90%, indicating that the external ointment can basically eliminate the symptoms and signs of onychomycosis patients and has excellent therapeutic efficacy.

[0068] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

[0069] The present invention and its implementation methods are described above, which is not restrictive. The drawings are only one of the implementation methods of the present invention, and the actual application is not limited thereto. In short, if ordinary technicians in the field are inspired by it and design methods and embodiments similar to the technical solution without creativity without departing from the purpose of the invention, they should all fall within the protection scope of the present invention.

Claims

1. An external liniment for treating tinea pedis and onychomycosis, characterized in that: The method is prepared from the following components in parts by weight: 5-15 parts of traditional Chinese medicine components, 2-20 parts of western medicine components, 10-20 parts of auxiliary agents and 30-50 parts of water; The Chinese medicinal components include the following components in parts by weight: 2-15 parts of Sophora flavescens, 3-20 parts of Dictamni cortex, 2-15 parts of Artemisia annua and 1-10 parts of Saposhnikovia divaricata; The western medicine component is sodium salicylate; and the auxiliary agent is edible white vinegar.

2. The external liniment for treating tinea pedis and onychomycosis according to claim 1, characterized in that: The method is prepared from the following components in parts by weight: 6-12 parts of traditional Chinese medicine components, 5-15 parts of western medicine components, 12-18 parts of auxiliary agents and 35-45 parts of water; The Chinese medicinal components include the following components in parts by weight: 5-12 parts of Sophora flavescens, 5-18 parts of Dictamni cortex, 3-12 parts of Artemisia annua and 2-8 parts of Saposhnikovia divaricata; The western medicine component is sodium salicylate; and the auxiliary agent is edible white vinegar.

3. The external liniment for treating tinea pedis and onychomycosis according to claim 2, characterized in that: The invention is prepared from the following components in parts by weight: 8-10 parts of traditional Chinese medicine components, 6-10 parts of western medicine components, 13-15 parts of auxiliary agents and 36-42 parts of water; The Chinese medicinal components include the following components in parts by weight: 6-10 parts of Sophora flavescens, 6-15 parts of Dictamni cortex, 4-10 parts of Artemisia annua and 3-6 parts of Saposhnikovia divaricata; The western medicine component is sodium salicylate; and the auxiliary agent is edible white vinegar.

4. The external liniment for treating tinea pedis and onychomycosis according to claim 3, characterized in that: The invention is prepared from the following components in parts by weight: 9 parts of Chinese medicine components, 7 parts of Western medicine components, 14 parts of adjuvants and 38 parts of water; The Chinese medicinal components include the following components in parts by weight: 7 parts of Sophora flavescens, 8 parts of Dictamni cortex, 6 parts of Artemisia annua and 5 parts of Saposhnikovia divaricata; The western medicine component is sodium salicylate; and the auxiliary agent is edible white vinegar.

5. The external liniment for treating tinea pedis and onychomycosis according to claim 4, characterized in that: Prepared by the following steps: Sophora flavescens, Dictamni cortex, Artemisia annua and Saposhnikovia divaricata are washed and dried, added to water with a mass 15 times that of the traditional Chinese medicine components, and boiled for 30 minutes, then filtered, and the filtered medicinal residues are added to water with a mass 10 times that of the medicinal residues and continued to boil for 30 minutes, and then filtered for a second time, and the two filtrates are combined, dehydrated under reduced pressure, and dried in a dryer until the moisture content is less than 2.5%, and then ground with a grinder, and then mixed with sodium salicylate and water to obtain the external ointment.

6. The external liniment for treating tinea pedis and onychomycosis according to claim 5, characterized in that: The drying temperature of the drying machine is 60-70°C.

7. The external liniment for treating tinea pedis and onychomycosis according to claim 6, characterized in that: The fineness of the Chinese medicinal raw materials after grinding is 100-150 meshes.

8. The external liniment for treating tinea pedis and onychomycosis according to claim 7, characterized in that: When the ointment is used to treat tinea pedis: the external ointment is applied to the skin area affected by tinea pedis, including between the toes, soles, heels and edges of the feet, twice a day, and continued to be used until the skin returns to normal.

9. The external liniment for treating tinea pedis and onychomycosis according to claim 8, characterized in that: When the ointment is used to treat onychomycosis: use a nail clipper or a file to trim the thickened part of the surface of the diseased nail, use a clean cotton ball to dip the external ointment, apply it to the surface of the diseased nail, the edge of the nail and the root of the nail, apply it twice a day, and continue to use it until the diseased nail returns to normal.

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