Medicated diet composition capable of invigorating spleen and reinforcing stomach and preparation method of medicated diet composition

Abstract

The invention belongs to the technical field of medicated diet preparation, and particularly relates to a medicated diet composition capable of invigorating the spleen and reinforcing the stomach and a preparation method thereof. The medicated diet composition capable of invigorating spleen and reinforcing stomach provided by the invention comprises powder and aromatic spleen-invigorating oil, wherein the powder comprises 60-80 parts of fried Chinese yam, 25-35 parts of fried malt, 50-70 parts of fried endothelium corneum gigeriae galli, 15-25 parts of poria cocos, 30-50 parts of fried lotus seed, 5-15 parts of fried black sesame, 30-40 parts of fried wheat flour, 25-40 parts of fried barley flour and 0.25-0.32 part of beta-cyclodextrin; the aromatic spleen-tonifying oil comprises 1-5 parts of amomum cardamomum oil and 2-10 parts of fructus amomi oil. According to the medicated diet composition capable of invigorating the spleen and reinforcing the stomach, the five-qi (five-odor) theory is innovatively introduced, through comprehensive regulation and tonifying of qi and taste, a formula in a powder form is provided, volatile oil components are added, tonifying of both qi and form is achieved, the effect of the medicated diet composition is remarkably improved, and the medicated diet composition has stronger treatment and health-care effects.

Description

Technical Field

[0001] The invention belongs to the technical field of medicinal food preparation, and particularly relates to a medicinal food composition for strengthening the spleen and stomach and a preparation method thereof. Background Art

[0002] With the rapid development of the modern economy, people's pace of life is accelerating. Modern people's living habits are often irregular. Coupled with the huge life pressure brought by the fast pace of life, many people have a series of health problems such as chronic gastroenteritis, weakened gastric motility, weight loss, chronic diarrhea and poor appetite.

[0003] For these symptoms, the use of Western medicine may cause serious consequences. A large amount of drugs cause great damage to the liver and kidneys, which is not worth the cost. The medicated diet therapy in traditional Chinese medicine theory provides a gentle and effective means of prevention and treatment. Chinese medicine has had the theory of "medicine and food are of the same origin" since ancient times. With the improvement of living standards, people pay more and more attention to medicated diet. In the existing Chinese medicine and medicated diet formulas, the four qi and five flavors are usually used as guidance, but there are few that use the five qi as a guide for the use of drugs and diet.

[0004] The five qi refer to the five smells of medicines and foods, namely, rancid, burnt, fragrant, fishy, ​​and rotten, also known as the five odors. "Suwen·Liujie Zangxiang Lun" says: "Heaven feeds people with five qi." Zhang Jingyue commented: "Heaven feeds people with five qi. Rancid qi enters the liver, burnt qi enters the heart, fragrant qi enters the spleen, fishy qi enters the lungs, and rotten qi enters the kidneys." Smell is the core concept in traditional Chinese medicine theory. When speaking relatively, qi generally refers to the five qi of rancid, burnt, fragrant, fishy, ​​and rotten perceived by the olfactory organ (mainly the nose); while taste refers to the five tastes of sour, bitter, sweet, pungent, and salty perceived by the taste organ. Qi belongs to Yang, taste belongs to Yin, and smell together determines the meridians of the medicine.

[0005] At the same time, "Suwen. Storing Qi and Using Food to Treat the Time" says: "Poisons attack evil, the five grains are for nourishment, the five animals are for benefit, the five fruits are for assistance, and the five vegetables are for filling. Take them together with their flavors to replenish essence and benefit Qi." This passage discusses the two major means of treating diseases, namely the so-called strengthening the body and eliminating evil. Poisons are used to eliminate evil, and food is used to strengthen the body. When talking about poisons, the flavors are not emphasized. In clinical practice, the efficacy of drugs is based on the four properties of the drugs, namely cold, hot, warm, and cool, and the five flavors, namely pungent, sweet, sour, bitter, and salty. When talking about food treatment, not only the five flavors are emphasized, but the qi of food is specifically mentioned, pointing out that the flavors should be taken together. For this reason, the use of flavors together enhances the effect of food treatment.

[0006] Therefore, in practical applications, providing a medicinal diet that reasonably matches the five flavors and five qi of food can better regulate the body and achieve the purpose of strengthening the spleen and stomach. Summary of the invention

[0007] In order to solve the problems existing in the prior art, the object of the present invention is to provide a spleen-strengthening and stomach-benefiting medicinal diet composition and a preparation method thereof.

[0008] The technical solution of the present invention is:

[0009] A medicinal diet composition for strengthening the spleen and stomach, comprising powder and aromatic spleen-strengthening oil;

[0010] The powder comprises the following raw materials in parts by weight:

[0011] 60-80 parts of stir-fried yam, 25-35 parts of stir-fried malt, 50-70 parts of stir-fried chicken gizzard lining, 15-25 parts of poria, 30-50 parts of stir-fried lotus seeds (core removed), 5-15 parts of stir-fried black sesame seeds, 30-40 parts of stir-fried wheat flour, 25-40 parts of stir-fried barley flour, and 0.25-0.32 parts of β-cyclodextrin;

[0012] The aromatic spleen-strengthening oil comprises the following raw materials in parts by weight:

[0013] 1 to 5 parts of white cardamom oil and 2 to 10 parts of amomum oil.

[0014] Furthermore, the powder comprises the following raw materials in parts by weight:

[0015] 65-75 parts of stir-fried yam, 28-32 parts of stir-fried malt, 55-65 parts of stir-fried chicken gizzard lining, 18-22 parts of poria, 35-45 parts of stir-fried lotus seeds (core removed), 8-12 parts of stir-fried black sesame seeds, 33-38 parts of stir-fried wheat flour, 30-38 parts of stir-fried barley flour, and 0.26-0.30 parts of β-cyclodextrin;

[0016] The aromatic spleen-strengthening oil comprises the following raw materials in parts by weight:

[0017] 2-4 parts of white cardamom oil and 3-6 parts of amomum oil.

[0018] Furthermore, the powder is composed of the following raw materials in parts by weight:

[0019] 70 parts of stir-fried yam, 30 parts of stir-fried malt, 60 parts of stir-fried chicken gizzard lining, 20 parts of Poria cocos, 40 parts of stir-fried lotus seeds (core removed), 10 parts of stir-fried black sesame seeds, 35 parts of stir-fried wheat flour, 35 parts of stir-fried barley flour, and 0.3 parts of β-cyclodextrin;

[0020] The aromatic spleen-strengthening oil is composed of the following raw materials in parts by weight:

[0021] 3 parts of white cardamom oil and 4 parts of amomum oil.

[0022] Furthermore, the preparation method of the white cardamom oil and the Amomum villosum oil in the aromatic spleen-strengthening oil provided by the present invention can be extracted by one of steam distillation, solvent extraction, pressing or carbon dioxide supercritical fluid extraction according to the properties of the white cardamom and the Amomum villosum.

[0023] Furthermore, the preparation method of the white cardamom oil in the aromatic spleen-strengthening oil comprises the following preparation steps:

[0024] Crush the white cardamom into 40-60 mesh, put it into supercritical carbon dioxide extraction equipment, extract it for 1.5-2.0 hours at a temperature of 40-50°C, a pressure of 30MPa, and a CO2 flow rate of 20-30kg / h to obtain white cardamom oil.

[0025] Furthermore, the preparation method of the Amomum villosum oil in the aromatic spleen-strengthening oil comprises the following preparation steps:

[0026] Take Amomum villosum and grind it into 20-50 mesh size, add 5-12 times of its mass of water, soak for 1-2 hours, and extract by steam distillation for 3-5 hours to obtain Amomum villosum oil.

[0027] Furthermore, the present invention also provides a method for preparing a spleen-strengthening and stomach-benefiting medicinal diet composition, comprising the following preparation steps:

[0028] (1) Preparing powder: Grinding stir-fried yam, stir-fried malt, stir-fried chicken gizzard lining, Poria cocos, stir-fried lotus seeds, stir-fried black sesame seeds, stir-fried wheat flour, stir-fried barley flour and β-cyclodextrin into powder, mixing well, and obtaining powder;

[0029] (2) preparing aromatic spleen-strengthening oil: mixing white cardamom oil and amomum villosum oil evenly to obtain aromatic spleen-strengthening oil;

[0030] (3) When eating, add boiling water to the powder, then add aromatic spleen-strengthening oil, stir well, and then it is ready to eat.

[0031] Furthermore, in the step (1), each raw material of the powder is ground into a powder with a particle size of 100 to 120 meshes.

[0032] Furthermore, the amount of boiling water added in step (3) is 200 to 300 parts.

[0033] In addition, the present invention also provides a use of the above-mentioned medicinal diet composition in preparing food and health products for strengthening the spleen and stomach.

[0034] It is a common method in traditional Chinese medicine to guide the formulation of traditional Chinese medicine and medicated diet with the four qi and five flavors. However, the present invention creatively introduces the five qi (five odors) to guide the formulation ratio and preparation of medicated diet on this basis.

[0035] The five qi refer to the five smells of medicines and foods, namely, rancid, burnt, fragrant, fishy, ​​and rotten, also known as the five odors. "Suwen·Liujie Zangxiang Lun" says: "Heaven feeds people with five qi." Zhang Jingyue commented: "Heaven feeds people with five qi. Rancid qi enters the liver, burnt qi enters the heart, fragrant qi enters the spleen, fishy qi enters the lungs, and rotten qi enters the kidneys." Smell is the core concept in traditional Chinese medicine theory. When speaking relatively, qi generally refers to the five qi of rancid, burnt, fragrant, fishy, ​​and rotten perceived by the olfactory organ (mainly the nose); while taste refers to the five tastes of sour, bitter, sweet, pungent, and salty perceived by the taste organ. Qi belongs to Yang, taste belongs to Yin, and smell together determines the meridians of the medicine.

[0036] The present invention adopts five qi to guide the medication meridian and diet: in the nature and flavor of traditional Chinese medicine meridian, the five qi (five odors) of rancid, burnt, fragrant, fishy and rotten together with the five flavors (sour, bitter, sweet, pungent and salty) and four properties (cold, hot, warm and cool) determine the properties of the medicine meridian and guide clinical medication. The "Inner Canon" records that "the essence is stored in the liver, its disease is shock, its taste is sour, its odor is rancid; the essence is stored in the heart, so the disease is in the five internal organs, its taste is bitter, its odor is burnt; the essence is stored in the spleen, so the disease is in the tongue root, its taste is sweet, its odor is fragrant; the essence is stored in the lungs, so the disease is in the back, its taste is pungent, its odor is fishy; the essence is stored in the kidneys, so the disease is in the valley, its taste is salty, its odor is rotten".

[0037] "Suwen·Liujie Zangxiang Lun" states: "Heaven feeds people with five qi, and earth feeds people with five flavors. The five qi enter the nose and are stored in the heart and lungs, making the five colors clear and the voice clear. The five flavors enter the mouth and are stored in the intestines and stomach. The flavors are stored to nourish the five qi. When the qi is harmonious and the body fluids are formed, the spirit is born." "Inner Canon of Medicine" states: "If the body is deficient, it should be supplemented with qi, and if the essence is deficient, it should be supplemented with flavor."

[0038] Based on the traditional four qi and five flavors, this method innovatively introduces the theory of five qi (five odors). Through the comprehensive adjustment of qi and taste, it not only provides a formula in powder form, but also adds volatile oil components, thus achieving the replenishment of both form and qi, thereby significantly improving the effect of the present invention and having stronger therapeutic and health-care effects.

[0039] Among them, the powdered medicinal food provided by the present invention has a reasonable compatibility relationship and ratio, with fried chicken gizzard lining as the main medicine:

[0040] Fried chicken gizzard lining: Nature and flavor: sweet, astringent, flat. Enters the spleen, stomach, and bladder meridians. Efficacy: invigorates the stomach and helps digestion, used to treat food stagnation, indigestion, and infantile malnutrition. It is a powerful digestive medicine among digestive medicines. In the present invention, the chicken gizzard lining is fried, ground into powder, and swallowed, and the efficacy is better than that of a decoction.

[0041] Use fried malt, fried yam, poria cocos, and fried lotus seeds as assistant drugs:

[0042] Roasted malt: Nature and flavor: salty, neutral. Enters the spleen, stomach, and liver meridians. Effects: Strengthens the stomach and helps digestion, used for food stagnation and indigestion. Good for eliminating rice, noodles, etc. It can enhance the effect of chicken gizzard lining.

[0043] Fried Chinese Yam: Nature and flavor: sweet, neutral. Enters the spleen, lung, and kidney meridians. Efficacy: tonifies the spleen and stops diarrhea, treats spleen and stomach weakness, poor appetite and fatigue, spleen deficiency diarrhea. Strengthens the kidney and consolidates the essence. Nourishes yin and produces body fluid. Food stagnation is mostly caused by spleen and stomach weakness, so strengthening the spleen can cure the root of stagnation. Chinese Yam can both tonify qi and nourish yin, and it tonifies without stagnation, nourishes yin without being greasy, and is the most peaceful product for nourishing the middle qi.

[0044] Poria: Nature and flavor: sweet, neutral. Enters the heart, spleen, stomach, lung, and kidney meridians. Efficacy: Strengthens the spleen and replenishes the middle, treats spleen deficiency, water retention, phlegm retention, and diarrhea. It can promote diuresis and eliminate dampness, and treat urinary dysfunction and edema caused by stagnant water retention. It can calm the mind and soothe the nerves. Poria is mild in nature, nourishing but not harsh, beneficial but not fierce, and can both strengthen the body and eliminate evil.

[0045] Fried lotus seeds: Nature and flavor: sweet, astringent, neutral. Enters the spleen, kidney, and heart meridians. Efficacy: tonifies the spleen and stops diarrhea, treats spleen deficiency diarrhea. Nourishes the kidneys and consolidates the essence, nourishes the heart and calms the mind.

[0046] The above-mentioned medicines with the same origin as food can enhance the efficacy of the main medicine, chicken gizzard lining.

[0047] Using black sesame as adjuvant:

[0048] Black sesame: Nature and flavor: sweet, neutral. Enters the spleen, lung, liver, and kidney meridians. Effects: nourishes the liver and kidneys, treats dizziness, tinnitus, and numbness of limbs caused by liver and kidney deficiency. Moisturizes and lubricates the intestines. In addition, lotus seeds and yam both have the effect of nourishing the kidneys. The kidney is the gateway to the stomach, and nourishing the kidneys plays an important role in the reception, transportation, and excretion of water and grain in the spleen and stomach. Therefore, it plays the role of adjuvant.

[0049] Using wheat flour and barley flour as adjuvant:

[0050] Fried wheat flour: Nature and flavor: sweet, slightly cold. Enters the heart, spleen, and kidney meridians. Efficacy: nourishes the heart and calms the mind, clears away heat and relieves restlessness, promotes diuresis and quenches thirst. Used for restlessness, palpitations, insomnia, and urinary problems. After frying, it is aromatic and can invigorate the spleen.

[0051] Fried barley flour: Nature and flavor: sweet, salty, cool. Enters the spleen and stomach meridians. Efficacy: replenishes qi and harmonizes the stomach, relieves stagnation and eliminates stagnation. Used for symptoms of spleen and stomach weakness such as indigestion, abdominal distension, diarrhea, etc.

[0052] Fried wheat and barley flour are commonly used cereals. In addition to their spleen-strengthening effect, they can also harmonize various medicines, correct the flavor, and supplement nutrition, so they have the effect of strengthening the spleen.

[0053] Furthermore, the aromatic spleen-strengthening oil added in the present invention is composed of Amomum villosum oil and white cardamom oil. Among them, Amomum villosum oil has the effect of warming the middle and dispersing cold, and is suitable for symptoms such as abdominal pain and diarrhea caused by spleen and stomach deficiency and cold. White cardamom oil has the effect of warming the middle and dispersing cold, and is suitable for symptoms such as abdominal pain and diarrhea caused by spleen and stomach deficiency and cold.

[0054] In summary, the medicinal diet composition for strengthening the spleen and stomach provided by the present invention not only pays attention to the five flavors, but also strengthens the importance of the five qi to the spleen and stomach, specifically, burnt into the heart, fragrant into the spleen, and heart fire generates spleen soil. The combination of the weather and the earth's qi to regulate the spleen and stomach emphasizes the concept of the three talents of heaven, man and earth. The magic of deficiency syndrome lies in the slow picture, so this formula slowly replenishes but not drastically, replenishes the spleen and moves the spleen, and overcomes the common problem of deficiency not being able to be replenished. In order to achieve the effect of burnt and fragrant entering the heart and spleen, almost all ingredients must be fried. By frying, the properties of the medicine can be changed, making it easier to be absorbed by the human body. At the same time, the aroma produced during the frying process can further enhance the therapeutic effect of the medicine and promote the coordination of the heart and spleen.

[0055] Compared with the prior art, the spleen-strengthening and stomach-benefiting medicinal diet composition provided by the present invention has the following advantages:

[0056] The spleen-strengthening and stomach-benefiting medicinal diet composition provided by the present invention emphasizes the rational preparation of traditional Chinese medicine and food. In the compatibility and formulation of medicines or foods, the combination is selected and prepared purposefully according to the properties of the medicines and foods. On the basis of the traditional four qi and five flavors, the theory of five qi (five odors) is innovatively introduced. Through the comprehensive adjustment of qi and taste, a powder form formula is provided, and volatile oil components are added, thereby achieving the replenishment of both form and qi, thereby significantly improving the effect of the present invention and having a stronger therapeutic and health-care effect.

[0057] The spleen-strengthening and stomach-benefiting medicinal diet composition prepared by the present invention has been subjected to long-term clinical observation and has good effects on various chronic gastroenteritis, weak gastric motility, body weight loss, chronic diarrhea, poor appetite and other symptoms, and has a significant improvement effect on various clinical symptoms of patients with chronic gastritis of spleen deficiency and qi stagnation type. Patient feedback shows that after using the spleen-strengthening and stomach-benefiting medicinal diet composition of the present invention, the spleen and stomach function is significantly improved, the digestion and absorption capacity is enhanced, and the physical condition gradually improves. DETAILED DESCRIPTION

[0058] The present invention is further illustrated below through the description of specific implementation methods, but this is not a limitation of the present invention. Those skilled in the art can make various modifications or improvements based on the basic idea of ​​the present invention, but as long as they do not deviate from the basic idea of ​​the present invention, they are all within the protection scope of the present invention.

[0059] In the following examples, reagents not specially described are conventional reagents and can be purchased from conventional reagent production and sales companies. The methods used are all prior arts unless otherwise specified.

[0060] Example 1 A medicinal diet composition for strengthening the spleen and stomach and a preparation method thereof

[0061] The medicinal diet composition for strengthening the spleen and stomach comprises powder and aromatic spleen-strengthening oil:

[0062] The powder is composed of the following raw materials:

[0063] Stir-fried yam 65g, stir-fried malt 28g, stir-fried chicken gizzard 55g, Poria 18g, stir-fried lotus seeds (core removed) 35g, stir-fried black sesame 8g, stir-fried wheat flour 33g, stir-fried barley flour 30g, β-cyclodextrin 0.25g;

[0064] The aromatic spleen-strengthening oil comprises the following raw materials:

[0065] 2mL white cardamom oil, 3mL amomum oil.

[0066] The preparation method of the white cardamom oil comprises the following preparation steps:

[0067] The white cardamom was crushed into 40 mesh, put into supercritical carbon dioxide extraction equipment, extracted for 2.0 hours at a temperature of 40°C, a pressure of 30MPa, and a CO2 flow rate of 30kg / h to obtain white cardamom oil.

[0068] The preparation method of Amomum villosum oil in the aromatic spleen-strengthening oil comprises the following preparation steps:

[0069] Take Amomum villosum and grind it into 20 mesh, add 12 times its mass of water, soak for 1 hour, and extract by steam distillation for 3 hours to obtain Amomum villosum oil.

[0070] The preparation and consumption method of the spleen-strengthening and stomach-benefiting medicinal diet composition comprises the following preparation steps:

[0071] (1) Preparing powder: Grind the above-mentioned fried yam, fried malt, fried chicken gizzard lining, Poria cocos, fried lotus seeds, fried black sesame seeds, fried wheat flour, fried barley flour and β-cyclodextrin into powder with a particle size of 100 mesh, mix them evenly, and obtain powder;

[0072] (2) preparing aromatic spleen-strengthening oil: uniformly mixing the white cardamom oil and the amomum villosum oil to obtain aromatic spleen-strengthening oil;

[0073] (3) When eating, add 200g of boiling water to the powder, then add aromatic spleen-strengthening oil, stir well, and it is ready to eat.

[0074] Example 2 A medicinal diet composition for strengthening the spleen and stomach and a preparation method thereof

[0075] The medicinal diet composition for strengthening the spleen and stomach comprises powder and aromatic spleen-strengthening oil:

[0076] The powder is composed of the following raw materials:

[0077] Stir-fried yam 70g, stir-fried malt 30g, stir-fried chicken gizzard 60g, Poria 20g, stir-fried lotus seeds (core removed) 40g, stir-fried black sesame 10g, stir-fried wheat flour 35g, stir-fried barley flour 35g, β-cyclodextrin 0.30g;

[0078] The aromatic spleen-strengthening oil is composed of the following raw materials:

[0079] 3g white cardamom oil, 4g amomum oil.

[0080] The preparation method of the white cardamom oil comprises the following preparation steps:

[0081] The white cardamom was crushed into 50 mesh, put into a supercritical carbon dioxide extraction equipment, and extracted for 2.0 hours at a temperature of 45°C, a pressure of 30MPa, and a CO2 flow rate of 25kg / h to obtain white cardamom oil.

[0082] The preparation method of Amomum villosum oil in the aromatic spleen-strengthening oil comprises the following preparation steps:

[0083] Take Amomum villosum and grind it into 40 mesh, add 8 times its mass of water, soak for 1.5 hours, and extract by steam distillation for 4 hours to obtain Amomum villosum oil.

[0084] The preparation and consumption method of the spleen-strengthening and stomach-benefiting medicinal diet composition comprises the following preparation steps:

[0085] (1) Preparing powder: Grind the above-mentioned fried yam, fried malt, fried chicken gizzard lining, Poria cocos, fried lotus seeds, fried black sesame seeds, fried wheat flour, fried barley flour and β-cyclodextrin into a powder with a particle size of 110 mesh, mix them evenly, and obtain powder;

[0086] (2) preparing aromatic spleen-strengthening oil: uniformly mixing the white cardamom oil and the amomum villosum oil to obtain aromatic spleen-strengthening oil;

[0087] (3) When eating, add 250g of boiling water to the powder, then add aromatic spleen-strengthening oil, stir well, and it is ready to eat.

[0088] Example 3 A medicinal diet composition for strengthening the spleen and stomach and a preparation method thereof

[0089] The medicinal diet composition for strengthening the spleen and stomach comprises powder and aromatic spleen-strengthening oil:

[0090] The powder is composed of the following raw materials:

[0091] Stir-fried yam 75g, stir-fried malt 32g, stir-fried chicken gizzard 65g, Poria 22g, stir-fried lotus seeds (core removed) 45g, stir-fried black sesame 12g, stir-fried wheat flour 38g, stir-fried barley flour 38g, β-cyclodextrin 0.32g;

[0092] The aromatic spleen-strengthening oil comprises the following raw materials:

[0093] 4mL white cardamom oil, 6mL amomum oil.

[0094] The preparation method of the white cardamom oil comprises the following preparation steps:

[0095] The white cardamom was crushed into 60 mesh, put into supercritical carbon dioxide extraction equipment, extracted for 1.5 hours at a temperature of 50°C, a pressure of 30MPa, and a CO2 flow rate of 20kg / h to obtain white cardamom oil.

[0096] The preparation method of Amomum villosum oil in the aromatic spleen-strengthening oil comprises the following preparation steps:

[0097] Take Amomum villosum and grind it into 50 mesh, add 5 times its mass of water, soak for 2 hours, and extract by steam distillation for 5 hours to obtain Amomum villosum oil.

[0098] The preparation and consumption method of the spleen-strengthening and stomach-benefiting medicinal diet composition comprises the following preparation steps:

[0099] (1) Preparing powder: Grind the above-mentioned fried yam, fried malt, fried chicken gizzard lining, Poria cocos, fried lotus seeds, fried black sesame seeds, fried wheat flour, fried barley flour and β-cyclodextrin into a powder with a particle size of 120 mesh, mix them evenly, and obtain powder;

[0100] (2) preparing aromatic spleen-strengthening oil: uniformly mixing the white cardamom oil and the amomum villosum oil to obtain aromatic spleen-strengthening oil;

[0101] (3) When eating, add 300g of boiling water to the powder, then add aromatic spleen-strengthening oil, stir well, and it is ready to eat.

[0102] Experimental example: Clinical observation on the treatment of chronic gastritis caused by spleen deficiency and qi stagnation by the medicinal diet composition of the present invention for strengthening the spleen and stomach

[0103] Chronic gastritis is a common digestive system disease in clinic. Its pathological changes are caused by multiple reasons that lead to chronic inflammation of gastric mucosa. The disease is not easy to cure and is prone to recurrence all year round. If not treated in time, it can develop into chronic atrophic gastritis and cause the occurrence of precancerous lesions. The present invention adopts a medicinal diet composition that strengthens the spleen and stomach, and organizes a clinical study on the medicinal diet treatment of chronic gastritis in the Department of Traditional Chinese Medicine of Shandong Qianfoshan Hospital. The results show that the medicinal diet composition that strengthens the spleen and stomach has a good clinical effect on chronic gastritis.

[0104] 1. Clinical data

[0105] 1.1 General Information

[0106] A total of 90 patients with chronic gastritis who were treated in the outpatient clinic and ward of Shandong Qianfoshan Hospital from August to November 2019 were included in this study. All subjects underwent gastroscopy and were diagnosed with chronic gastritis. There were 45 males and 45 females in the study. The age ranged from 26 to 76 years old, with an average age of 42.8±9.3 years. The course of the disease in the study subjects ranged from 1 to 20 years, with an average time of 3.5±6.3 years. This study has been approved by the Medical Ethics Committee of Shandong Qianfoshan Hospital.

[0107] 1.2 Diagnostic criteria

[0108] The Western medical diagnosis standard of chronic gastritis is based on the Western medical diagnosis standard of chronic gastritis in the Consensus of Chinese Medicine Diagnosis and Treatment Experts on Chronic Gastritis (2017): patients diagnosed with non-atrophic gastritis or atrophic gastritis by electronic gastroscopy. The Chinese medicine dialectical standard is based on the standards of the main symptoms and secondary symptoms. The main symptoms are swelling, pain and discomfort in the epigastric region. The secondary symptoms involve the causes and accompanying symptoms of the attack. The causes are mostly careless diet and fatigue. The accompanying symptoms include mental fatigue, fatigue and weakness in the limbs, lack of breath and laziness, inability to digest food, lack of fragrance in food, pale tongue, thick white tongue coating, obvious tooth marks on the edge of the tongue, and stringy and thin pulse. If two of the main symptoms and secondary symptoms are present, and the tongue coating and pulse of the research subject are used at the same time, the spleen deficiency and qi stagnation syndrome can be diagnosed.

[0109] 1.3 Inclusion criteria

[0110] The subjects who meet the diagnostic standards of Western medicine and the standards of TCM dialectics should be included. At the same time, it is necessary to ensure that all subjects stop using other TCM therapies, including Chinese medicine, acupuncture, massage, and other medicated diet therapy, during the trial, and give informed consent to use the medicated diet in this study for treatment. All subjects signed the informed consent form for this study before the start of the study.

[0111] 1.4 Exclusion criteria

[0112] Patients with severe cardiovascular and cerebrovascular diseases, mental disorders, liver and kidney diseases, and pregnancy were excluded. If the subjects developed severe complications such as intestinal obstruction and gastrointestinal bleeding during the study, or if they withdrew from the study due to their own reasons, they should be excluded.

[0113] 2. Treatment Methods

[0114] All subjects were treated with the medicinal diet composition prepared in Example 2 of the present invention. Take it twice a day, and three weeks is one course of treatment. During the treatment period, all subjects were prohibited from smoking, drinking, drinking strong tea, and coffee, and avoiding spicy and greasy foods in their daily diet. During this study, the three meals of the subjects were required to be regular and quantitative, avoid excessive satiety and hunger, avoid excessive fatigue and emotional excitement, and pay attention to avoid wind and cold.

[0115] 3. Observation of therapeutic effects

[0116] 3.1 Observation indicators

[0117] The efficacy indicators include two aspects: TCM syndrome score and the degree of improvement of clinical symptoms.

[0118] The TCM syndrome score observation indicators include: indigestion, upper abdominal pain, acid reflux, belching, chills, fatigue and other symptoms. Each indicator is assigned different scores according to the severity of the clinical degree of the research subject. The higher the score, the more severe the clinical symptoms, and vice versa. Specifically, 0 points means no clinical symptoms, 1 point means that the patient has only mild manifestations, 2 points means that the patient's clinical symptoms are more severe, and if the patient's clinical manifestations are very severe, 3 points are assigned. The score is proportional to the severity of the clinical symptoms.

[0119] In terms of clinical efficacy, the corresponding grading is carried out according to the degree of reduction of TCM syndrome score, including three levels: markedly effective, effective, and ineffective. The higher the reduction of TCM syndrome score, the more significant the clinical efficacy, and vice versa. Specifically, a reduction of ≥80% in TCM syndrome score is considered markedly effective, if the reduction of TCM syndrome score is within the range of 45% to 80%, it is considered effective, and if the reduction of TCM syndrome score is <45%, it is considered ineffective. The overall effective rate of this study is calculated based on the sum of the total number of markedly effective and effective cases, and the calculation formula is: total effective rate = (number of markedly effective cases + number of effective cases) / total number of cases × 100%.

[0120] 3.2 Statistical analysis

[0121] SPSS 21.0 was used for statistical analysis in this study. The measurement data were analyzed using the t test; the count data were analyzed using the χ 2 P<0.05 indicated that the difference was statistically significant.

[0122] 4. Research Results

[0123] (1) TCM syndrome score

[0124] In terms of TCM syndrome scores, the results showed that after the patients with chronic gastritis were treated with the spleen-strengthening and stomach-benefiting medicinal diet composition, the TCM syndrome score of the subjects after treatment was 5.26 points, which was significantly lower than the 15.35 points before treatment. The difference in TCM syndrome scores before and after treatment was statistically significant. This shows that the spleen-strengthening and stomach-benefiting medicinal diet composition can effectively improve the TCM syndrome scores of patients.

[0125] (2) Clinical efficacy

[0126] In terms of clinical effects, the clinical efficacy of the subjects before and after treatment was compared according to their clinical manifestations such as indigestion, upper abdominal pain, acid reflux, belching, chills, and fatigue. The results showed that the clinical symptoms of the patients were improved, and the total effective rate of each symptom was greater than 80%. Among them, the improvement of upper abdominal pain was the best, with a total effective rate of 97.8%, followed by belching, with a total effective rate of 96.7%, and acid reflux and indigestion ranked third, fatigue and chills ranked fourth, fifth, and sixth respectively. The specific results are shown in Table 1.

[0127] Table 1 Total effective rate of symptoms in 90 patients with chronic gastritis of spleen deficiency and qi stagnation type

[0128] symptom Significantly effective (example) Valid (Example) Invalid (Example) Total effective rate (%) Upper abdominal pain 52 36 2 97.8 Belching 24 63 3 96.7 Acid reflux 14 67 9 90.0 indigestion 12 64 14 84.4 Fatigue 7 67 16 82.2 Chills 10 59 21 76.7

[0129] 4. Discussion

[0130] Chronic gastritis has a high clinical prevalence, and the incidence of the disease has been trending towards younger and younger patients in recent years. The course of the disease is prolonged and often difficult to cure completely. Clinical symptoms often recur, seriously affecting the patient's quality of life and work, and even interfering with the patient's mental and psychological health in severe cases. If pathological changes such as intestinal metaplasia and intraepithelial neoplasia occur, the risk of malignant transformation is often significantly higher than that of patients without such pathological changes.

[0131] At present, the treatment of chronic gastritis in Western medicine mainly includes eradication of the cause and improvement of symptoms. In terms of etiology, the main treatment is to eradicate Helicobacter pylori, but Helicobacter pylori has a strong survival ability and is often difficult to completely eradicate, and the chance of re-infection is very high. In terms of symptom improvement, it mainly involves protecting the gastric mucosa, improving gastric motility, and appropriately supplementing B vitamins, etc., but its clinical effect still needs to be further improved. Traditional Chinese medicine has a long history of understanding this disease. Although there is no name of "gastritis" in traditional Chinese medicine, according to the clinical manifestations of the disease, the disease can be included in the categories of "stomach pain", "acid reflux", "fullness", "noise", and "nausea" in traditional Chinese medicine. Traditional Chinese medicine conducts a dialectical analysis of deficiency and excess for different clinical syndromes of the disease, and the clinical manifestations are divided into excess syndrome, deficiency syndrome, and mixed deficiency and excess syndrome. The main excess syndromes are spleen and stomach damp-heat syndrome, liver and stomach qi stagnation syndrome, and stomach collateral stasis syndrome; the deficiency syndromes are spleen and stomach qi deficiency syndrome, spleen and stomach deficiency cold syndrome, and stomach yin deficiency syndrome. Mixed deficiency and excess syndromes are mostly spleen deficiency and qi stagnation syndromes. Patients are old and weak or have been ill for a long time, which leads to deficiency of internal organs, or due to long-term improper diet, spleen and stomach damage, spleen and stomach yang deficiency, weak transportation and transformation, lack of nourishment to the stomach, and poor operation of qi, and lack of transportation and transformation of water and grain essence. Spleen deficiency and qi stagnation syndrome is more common in the elderly or patients with chronic diseases. The results of this study showed that the TCM syndrome scores of the research subjects were significantly lower than before treatment after taking the medicinal diet composition for strengthening the spleen and stomach, and the total effective rate of improvement of multiple clinical symptoms was ≥80.0%, indicating that the medicinal diet composition for strengthening the spleen and stomach provided by the present invention has significant clinical efficacy on patients with chronic gastritis of spleen deficiency and qi stagnation type, and is worthy of further clinical promotion for the benefit of patients.

[0132] The above embodiments are merely illustrative of the principles and effects of the present invention, and are not intended to limit the present invention. Anyone familiar with the art may modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by a person of ordinary skill in the art without departing from the spirit and technical concept disclosed by the present invention shall still be covered by the claims of the present invention.

Claims

1. A medicinal diet composition for strengthening the spleen and stomach, characterized in that: Includes powders and aromatic spleen-strengthening oils; The powder comprises the following raw materials in parts by weight: 60-80 parts of stir-fried yam, 25-35 parts of stir-fried malt, 50-70 parts of stir-fried chicken gizzard lining, 15-25 parts of poria, 30-50 parts of stir-fried lotus seeds, 5-15 parts of stir-fried black sesame seeds, 30-40 parts of stir-fried wheat flour, 25-40 parts of stir-fried barley flour, and 0.25-0.32 parts of β-cyclodextrin; The aromatic spleen-strengthening oil comprises the following raw materials in parts by weight: 1 to 5 parts of white cardamom oil and 2 to 10 parts of amomum oil.

2. The spleen-strengthening and stomach-benefiting medicinal diet composition according to claim 1, characterized in that: The powder comprises the following raw materials in parts by weight: 65-75 parts of stir-fried yam, 28-32 parts of stir-fried malt, 55-65 parts of stir-fried chicken gizzard lining, 18-22 parts of poria, 35-45 parts of stir-fried lotus seeds, 8-12 parts of stir-fried black sesame seeds, 33-38 parts of stir-fried wheat flour, 30-38 parts of stir-fried barley flour, and 0.26-0.30 parts of β-cyclodextrin; The aromatic spleen-strengthening oil comprises the following raw materials in parts by weight: 2-4 parts of white cardamom oil and 3-6 parts of amomum oil.

3. The spleen-strengthening and stomach-benefiting medicinal diet composition according to claim 1, characterized in that: The powder is composed of the following raw materials in parts by weight: 70 parts of stir-fried yam, 30 parts of stir-fried malt, 60 parts of stir-fried chicken gizzard lining, 20 parts of Poria cocos, 40 parts of stir-fried lotus seeds, 10 parts of stir-fried black sesame seeds, 35 parts of stir-fried wheat flour, 35 parts of stir-fried barley flour, and 0.3 parts of β-cyclodextrin; The aromatic spleen-strengthening oil is composed of the following raw materials in parts by weight: 3 parts of white cardamom oil and 4 parts of amomum oil.

4. The spleen-strengthening and stomach-benefiting medicinal diet composition according to any one of claims 1 to 3, characterized in that: The preparation method of the white cardamom oil and the amomum villosum oil in the aromatic spleen-strengthening oil can adopt one of the following methods: steam distillation, solvent extraction, pressing or carbon dioxide supercritical fluid extraction.

5. The spleen-strengthening and stomach-benefiting medicinal diet composition according to claim 4, characterized in that: The preparation method of the white cardamom oil in the aromatic spleen-strengthening oil comprises the following preparation steps: Crush the white cardamom into 40-60 mesh, put it into supercritical carbon dioxide extraction equipment, extract it for 1.5-2.0 hours at a temperature of 40-50°C, a pressure of 30MPa, and a CO2 flow rate of 20-30kg / h to obtain white cardamom oil.

6. The spleen-strengthening and stomach-benefiting medicinal diet composition according to claim 4, characterized in that: The preparation method of Amomum villosum oil in the aromatic spleen-strengthening oil comprises the following preparation steps: Take Amomum villosum and grind it into 20-50 mesh size, add 5-12 times of its mass of water, soak for 1-2 hours, and extract by steam distillation for 3-5 hours to obtain Amomum villosum oil.

7. The method for preparing the spleen-tonifying and stomach-benefiting medicinal diet composition according to any one of claims 1 to 6, comprising the following preparation steps: (1) Preparing powder: Grinding stir-fried yam, stir-fried malt, stir-fried chicken gizzard lining, Poria cocos, stir-fried lotus seeds, stir-fried black sesame seeds, stir-fried wheat flour, stir-fried barley flour and β-cyclodextrin into powder, mixing well, and obtaining powder; (2) preparing aromatic spleen-strengthening oil: mixing white cardamom oil and amomum villosum oil evenly to obtain aromatic spleen-strengthening oil; (3) When eating, add boiling water to the powder, then add aromatic spleen-strengthening oil, stir well, and then it is ready to eat.

8. The method for preparing the spleen-tonifying and stomach-benefiting medicinal diet composition according to claim 7, characterized in that: In the step (1), the raw materials of the powder are ground into powder with a particle size of 100 to 120 meshes.

9. The method for preparing the spleen-tonifying and stomach-benefiting medicinal diet composition according to claim 7, characterized in that: The amount of boiling water added in step (3) is 200 to 300 parts.

10. Use of the medicinal diet composition according to any one of claims 1 to 6 in preparing foods and health products for strengthening the spleen and stomach.