Medicated food bag with blood fat regulating effect and preparation method thereof
By adopting the traditional Chinese medicinal materials selected by traditional Chinese medicine theory in medicinal products, a high-dose medicinal food package was designed, which solved the problem of existing medicinal food products that failed to effectively solve the problem of hyperlipidemia, and achieved the effect of significantly reducing blood lipids and promoting intestinal health.
Patent Information
- Application Number
- CN202411729072.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-28
- Publication Date
- 2025-02-28
AI Technical Summary
While improving taste, existing medicinal products have failed to truly and effectively solve the problem of hyperlipidemia and lack the basis of traditional Chinese medicine theory.
Using the traditional Chinese medicinal materials selected in traditional Chinese medicine theory, by improving the health of the digestive tract, a high-dose medicinal package was designed, including medicinal materials such as Magnolia officinalis, bamboo shoots, white rice, Cistanche, aloe, Yuli, Jinyingzi, Astragalus and Angelica, which were prepared by mixing decoction and mixing concentrate to form a solid or liquid form product.
It significantly reduced the total cholesterol, low-density lipoprotein cholesterol and triglyceride levels in mice, promoted intestinal peristalsis, enhanced the spleen and stomach transportation and transformation function, and achieved the effect of treating hyperlipidemia and preventing cardiovascular and cerebrovascular diseases.
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Abstract
Description
Technical Field
[0001] The invention relates to the technical field of health food, and in particular to a medicated diet package with blood lipid regulating function and a preparation method thereof. Background Art
[0002] Hyperlipidemia is one of the main factors leading to cardiovascular and cerebrovascular diseases. Hyperlipidemia is not only significantly harmful, but also has a high incidence rate. Studies over the past 20 years have shown that the prevention and treatment of hyperlipidemia, especially hypercholesterolemia, can significantly reduce the morbidity and mortality of cardiovascular diseases. Therefore, the treatment of hyperlipidemia is of great significance for the prevention of cardiovascular and cerebrovascular diseases. The "fat" mentioned in traditional Chinese medicine is similar to the "blood lipids" in Western medicine and can be regarded as the same pathological indicator. Traditional Chinese medicine believes that fat flows with the blood to provide nutrition for the internal organs, limbs and brain marrow. However, due to excessive intake or abnormal transmission, utilization and excretion functions at the same time, fat accumulation in the blood may occur, and the body fluid and fat are not transported smoothly, further converted into dampness and phlegm, and then soaked in the meridians, affecting the circulation of qi and blood, leading to dysfunction of the internal organs. Insufficient spleen and stomach function will lead to poor transportation and metabolism, imbalance of water metabolism, thus gathering dampness and generating phlegm, and phlegm blocking the qi. Hyperlipidemia is closely related to intestinal health. As hyperlipidemia develops, microvascular embolism may intensify, leading to obstruction of intestinal blood flow, thereby slowing down the transportation of food residues in the intestine and increasing the risk of constipation. In addition, patients with hyperlipidemia are often obese, and abdominal fat accumulation will compress the intestine, further aggravating constipation symptoms. In some cases, hyperlipidemia can also manifest as diarrhea. When blood lipid levels are too high, chylomicrons enter the intestinal cavity, stimulate the intestinal wall, increase water and electrolyte secretion, and cause diarrhea. Therefore, the intestinal health of patients with hyperlipidemia is closely related to the progression of their disease.
[0003] Medicinal food is the product of the combination of traditional Chinese medical knowledge and cooking experience. It is a delicious food with certain color, fragrance, taste and shape made by matching certain Chinese medicines with medicinal value with food, using China's unique dietary cooking technology and modern scientific methods. It not only uses medicine as food, but also gives food medicinal properties. The medicine borrows the power of food, and food helps the power of medicine. The two complement each other and bring out the best in each other. It not only has high nutritional value, but also can prevent and cure diseases, maintain health, and prolong life.
[0004] CN112568381B discloses the field of medicinal food processing technology, and provides a method for preparing a medicinal chicken soup of polygonatum, which comprises the following steps: taking an old hen raised in a farm for two years, washing and blanching it, and then boiling it on low heat for 20-30 minutes, weighing the cooked polygonatum obtained by nine steaming and nine drying, crushing it, and then performing two ultrasonic extractions, extracting and filtering, putting the polygonatum residue into chicken soup and boiling it for 20 minutes, and then taking out the polygonatum residue, and putting the chicken soup, polygonatum extract, and freeze-dried pineapple slices into a stew pot and stewing them in water. The present invention can fully and efficiently extract polygonatum, ensure the full utilization of the nutrients of polygonatum and make it fully integrated with chicken and chicken soup, put freeze-dried pineapple slices into the chicken soup, and freeze-dried pineapple slices contain protease, which can promote the proteolysis of chicken, and give the chicken soup a new flavor and aroma, and the taste is better. It can be seen that the current medicinal diet only improves the taste and has no real effect.
[0005] CN113100386B discloses a medicated meal replacement powder and a preparation method thereof, wherein the medicated meal replacement powder comprises the following raw materials in parts by weight: 41-55 parts of black rice, 15-20 parts of buckwheat, 4-6 parts of wolfberry, 2-3 parts of sea buckthorn, 0.5-1 part of orange peel, 5-6 parts of yam, 0.5-1 part of coix seed, 0.5-2 parts of wax gourd, 0.5-1 part of carrot, 1-2 parts of soy protein isolate, 1-6 parts of tuckahoe, 2-6 parts of polygonatum, 1-2 parts of spinach seed, 0.1- 0.5 parts, 0.4-0.8 parts of Amomum villosum, 2-5 parts of Monk Fruit, 3-6 parts of Licorice, 0.3-0.5 parts of Cinnamon Bark, 0.1-0.6 parts of Star Anise; the preparation method is a multi-path step-by-step polymerization processing method, and the prepared medicated meal replacement powder has the characteristics of high content of effective ingredients, fast release, and significant effect of lowering blood lipids. The preparation method can be widely used in the preparation of medicated meal replacement powders with the functions of nourishing the liver and kidney, nourishing the lungs and invigorating the spleen, nourishing blood and improving intelligence, nourishing qi and nourishing the heart, calming the mind and calming the mind, and nourishing the stomach. This patent has no clear theoretical basis of traditional Chinese medicine.
[0006] It can be seen that medicinal meal replacement products that are purely natural, taste good, retain the nutrients in grains intact, can maintain the natural aroma and taste of medicinal food, and have certain health functions often cannot achieve the expected therapeutic effect. It is necessary to enhance the overall function of the patient's digestive tract to achieve long-term health benefits. The present invention provides a high-dose dual-purpose medicine and food that can be used to regulate blood lipids. This product can also be used as a dietary material in the home and catering, providing an effective and easily accepted conditioning method for patients with cardiovascular and cerebrovascular diseases. Summary of the invention
[0007] In view of the close relationship between hyperlipidemia and digestive tract health in traditional Chinese medicine theory, the present invention proposes a high-dose composition that can improve the function of the middle and lower jiao. The composition targets the stomach, spleen and intestines, selects appropriate Chinese medicinal materials according to traditional Chinese medicine theory, and achieves the effect of treating hyperlipidemia and preventing cardiovascular and cerebrovascular diseases by improving digestive tract health.
[0008] The invention provides a medicated meal package with the effect of regulating blood lipids. The medicated meal package is prepared by extracting the following Chinese medicinal raw materials: magnolia officinalis flower, bamboo shoots, bletilla striata, cistanche deserticola, aloe, Prunus mume seeds, Rosa laevigata fruit, astragalus, and angelica.
[0009] The medicinal diet package with blood lipid regulating effect comprises the following medicinal raw materials in proportion by weight: 1-3 parts of magnolia officinalis flower, 7.5-22.5 parts of bamboo shoots, 2-6 parts of white schizonepeta, 3-9 parts of cistanche, 0.5-2 parts of aloe, 2-6 parts of prunus mume seeds, 2-6 parts of rosa laevigata, 3-9 parts of astragalus, and 2-6 parts of angelica.
[0010] The medicinal diet package with the effect of regulating blood lipids comprises the following medicinal raw materials in the following weight proportions: 2 parts of magnolia officinalis flower, 15 parts of bamboo shoots, 4 parts of white schizonepeta, 6 parts of cistanche, 1 part of aloe, 4 parts of Prunus mume seeds, 4 parts of Rosa laevigata fruit, 6 parts of astragalus, and 4 parts of angelica.
[0011] The preparation method of the medicinal food package with the effect of regulating blood lipids comprises the following steps: (1) soaking Magnolia officinalis flower, Bletilla striata, Cistanche deserticola, Aloe vera, Prunus mume, Rosa laevigata, Astragalus membranaceus and Angelica sinensis in water, decocting for the first time, filtering, adding water, decocting for the second time, combining the two decoctions, filtering and concentrating to obtain a concentrated solution; (2) preparing bamboo shoot liquid: soaking bamboo shoots in water, homogenizing and filtering to obtain bamboo shoot liquid; (3) mixing the concentrated solution obtained in step (1) and the bamboo shoot liquid obtained in step (2) evenly, concentrating and obtaining a solid product or a liquid product.
[0012] The preparation method of the medicinal meal package with blood lipid regulating effect comprises the following steps: the amount of water added for soaking is 8 times the weight of the medicinal materials, the soaking time is 0.5 hours, the amount of water added for the second decoction is 6 times the weight of the medicinal materials, the first decoction takes 45 minutes, and the second decoction takes 30 minutes.
[0013] In the preparation method of the medicinal meal package having the effect of regulating blood lipids, the amount of water added to the bamboo shoots for soaking is 20 times the weight of the bamboo shoots.
[0014] In the preparation method of the medicinal food package with the effect of regulating blood lipids, the solid form product is a granule, and the liquid form product is a decoction.
[0015] The medicinal food package with blood lipid regulating function is used in preparing health food for inhibiting hyperlipidemia.
[0016] A method for preparing a medicinal chicken comprises the steps of slaughtering and cleaning the chicken, decocting, sterilizing, freezing, and packaging for refrigeration. The specific steps are as follows:
[0017] (1) Slaughtering chickens: Select healthy live chickens with a lifespan of more than one year and slaughter them, and clean them thoroughly;
[0018] (2) decoction: put the cleaned chicken into the medicinal meal package of claim 1 and an appropriate amount of seasoning, add water and decoct for 1 hour, the weight of the Chinese medicine contained in the medicinal meal package being 1 / 5 of the weight of the chicken;
[0019] (3) Sterilization: Put the boiled chicken into a sterilization box and sterilize it with the help of 2000-3000 Hz ultrasound, so that the temperature in the sterilization box is maintained at 80-100° C. for 5-8 minutes;
[0020] (4) Freezing: Cooling for 40-60 minutes at a relative humidity of 80%-90%, a wind speed of 3-5 m / s, a cooling temperature of -20°C, and an ultrasonic wave of 2000-3000 Hz;
[0021] (5)Package and refrigerate.
[0022] A method for preparing a medicinal duck comprises the steps of slaughtering the duck, cleaning it, boiling it, sterilizing it, freezing it, and packaging it for refrigeration. The specific steps are as follows:
[0023] (1) Slaughtering ducks: Select healthy live ducks with a lifespan of more than one year for slaughter and clean them thoroughly;
[0024] (2) decoction: put the cleaned duck into the medicinal meal package of claim 1 and an appropriate amount of seasoning, add water and decoct for 1 hour, the weight of the Chinese medicine contained in the medicinal meal package is 1 / 5 of the weight of the duck;
[0025] (3) Sterilization: Place the boiled duck in a sterilization box and sterilize it with the aid of 2000-3000 Hz ultrasonic waves, keeping the temperature in the sterilization box at 80-100° C. for 5-8 minutes;
[0026] (4) Freezing: Cooling for 40-60 minutes at a relative humidity of 80%-90%, a wind speed of 3-5 m / s, a cooling temperature of -20°C, and an ultrasonic wave of 2000-3000 Hz;
[0027] (5)Package and refrigerate.
[0028] This product has the effect of regulating blood lipids and can also be added to food for stewing into medicinal foods such as old duck soup, turtle soup, and black chicken soup.
[0029] The Chinese medicine raw materials all meet the pharmacopoeia standards.
[0030] Magnolia officinalis flower: It is the flower bud of Magnolia officinalis (Rehder & E.H.Wilson) NHXia & C.Y.Wu or Magnolia officinalis Rehd.et Wils.var.biloba Rehd.et Wils.[M.biloba(Rehd.et Wils.)Cheng. It belongs to the spleen meridian and stomach meridian. It has the effects of promoting qi and relieving fullness, relieving depression and removing dampness. It is suitable for symptoms such as liver and stomach qi stagnation, chest and abdominal distension, and loss of appetite, and can resolve spleen and stomach dampness.
[0031] Bamboo shoots: They are the tender shoots of various bamboo plants, such as Phyllostachys dulcis Rendle, Phyllostachys sedulis (Carrière) J. Houz., and Phyllostachys nigra (Lodd. ex Lindl.) Munro. They enter the stomach and large intestine meridians. They have the effects of clearing away heat, eliminating phlegm, and stopping diarrhea.
[0032] Cistanche deserticola: It is the fleshy stem of Cistanche deserticola Ma, a plant of the Orobanchaceae family. It belongs to the large intestine meridian. It can moisturize the intestines and promote intestinal movement.
[0033] Aloe: It is a dried product of the concentrated juice from the leaves of the plant Aloe vera (L.) Burm.f. of the Liliaceae family. It enters the stomach meridian and large intestine meridian. It has the effect of clearing away heat and relieving constipation. It is suitable for constipation caused by heat accumulation and has the effect of strengthening the stomach and relieving menstruation.
[0034] Prunus humilis Bunge., Prunus japonica Thunb., Prunus triloba Lindl., Prunus pedunculata Maxim., Prunus humilis Bunge., Prunus japonica Thunb., Prunus triloba Lindl., Prunus pedunculata Maxim., Prunus pedunculata, Prunus humilis Bunge. ...
[0035] Bletilla striata: It is the dried tuber of Bletilla striata (Thunb.ex A.Murray) Rchb.f., an orchid plant. It has the functions of nourishing the lungs and stopping bleeding, nourishing the stomach and promoting muscle growth. It is suitable for gastrointestinal bleeding symptoms such as bleeding gastric and duodenal ulcers, and has the function of protecting the gastric mucosa.
[0036] Rosa laevigata: It is the dried mature fruit of the plant Rosa laevigata Michx. of the Rosaceae family. It enters the large intestine meridian and has the effect of astringing the intestines and stopping diarrhea.
[0037] Astragalus: It is the root of Astragalus membranaceus (Fisch.) Bunge and Astragalus membranaceus var.mongholicus (Bunge)PKHsiao, both plants of the Leguminosae family. It belongs to the spleen meridian and is used for symptoms such as qi deficiency and fatigue, poor appetite and loose stools, sinking of qi in the middle, chronic diarrhea and prolapse of the anus, and bloody stool and metrorrhagia.
[0038] Angelica sinensis: It is the dried root of Angelica sinensis (Oliv.) Diels, a plant of the Umbelliferae family. It enters the liver meridian, heart meridian, and spleen meridian, and is suitable for symptoms such as dry intestines, constipation, and heaviness after dysentery.
[0039] Beneficial effects:
[0040] 1. Traditional Chinese medicine believes that hyperlipidemia is classified as "phlegm" and "blood stasis". Hyperlipidemia is mainly caused by factors such as irregular diet, long sitting and sleeping, and lack of exercise. These bad living habits prevent the fat from being normally converted into the blood, or the poor qi movement causes the fat to accumulate in the body. The pathogenesis is mostly spleen deficiency and dampness, and endogenous phlegm; emotional discomfort affects the liver's function of dispersing and discharging, which leads to qi stagnation and blood stasis, and then causes hyperlipidemia. Insufficient spleen and stomach function will lead to poor transportation and transformation, imbalance in water metabolism, and thus accumulation of dampness to produce phlegm, and phlegm turbidity blocks the qi. The high dose of the present invention uses Magnolia officinalis flower and bamboo shoots as the main medicine. Magnolia officinalis flower promotes qi and relieves dampness. "New Reference to Medicinal Pieces": Magnolia officinalis flower relieves qi and regulates qi. Treat chest tightness and resolve spleen and stomach dampness. "Sichuan Chinese Medicine Records": Magnolia officinalis flower relieves chest and regulates diaphragm, and descends adverse qi. Bamboo shoots can clear away heat and eliminate phlegm, and are rich in cellulose. The combination of the two can dissolve spleen and stomach dampness, clear away heat and eliminate phlegm, promote the circulation of qi and blood, and enhance the transportation of body fluids and fats. Traditional Chinese medicine believes that hyperlipidemia is caused by the reduced ability of the human body to distinguish between clear and turbid. The spleen and stomach are the foundation of the acquired constitution and the source of qi and blood biochemistry. Spleen and stomach dysfunction cannot normally transport and transform the essence of water and grain, leading to endogenous phlegm and dampness, and internal obstruction of phlegm and turbidity, thereby causing hyperlipidemia. The present invention uses Bletilla striata, Cistanche deserticola, Aloe vera and Prunus mume as ministerial drugs to assist the monarch drug, enhance gastrointestinal peristalsis, protect intestinal health, and promote the metabolism of body fluids and fats in the body; because Cistanche deserticola, Aloe vera and Prunus mume have a laxative effect and are easy to consume yang energy, Rosa laevigata is used as an adjuvant to avoid diarrhea and abdominal pain caused by intestinal dampness and heat under hyperlipidemia and regulate intestinal function; at the same time, Astragalus and Angelica sinensis are used as messengers to enter the spleen meridian to enhance the transportation and transformation function of the spleen and stomach. The whole formula can dissolve dampness in the spleen and stomach, clear away heat and eliminate phlegm, enhance gastrointestinal motility, protect intestinal health, promote the metabolism of body fluids and fats, enhance the functions of the middle and lower parts of the body, target the stomach, spleen and intestines, and achieve the effect of treating hyperlipidemia.
[0041] 2. Hyperlipidemia is a major risk factor for cardiovascular and cerebrovascular diseases. This high-dose diet package provides a medicated diet package that can treat hyperlipidemia through carefully selected Chinese medicinal materials. Animal experimental results show that this medicated diet package has significant effects in inhibiting hyperlipidemia indicators, enhancing intestinal function and reducing weight. BRIEF DESCRIPTION OF THE DRAWINGS
[0042] Figure 1 :Effects of high, medium and low doses of medicated diet packages on body weight of mice
[0043] Figure 2 :Effects of high, medium and low doses of medicated diet packages on intestinal propulsion rate in mice
[0044] Figure 3 :Effects of high, medium and low doses of medicated diet packages on total cholesterol levels in mice
[0045] Figure 4 :Effects of high, medium and low doses of medicated diet packages on low-density lipoprotein cholesterol levels in mice
[0046] Figure 5 :Effects of high, medium and low doses of medicated diet packages on triglyceride levels in mice DETAILED DESCRIPTION
[0047] The present invention will be further described below in conjunction with specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the content of the present invention, those skilled in the art can make various changes or modifications to the present invention, but these equivalent forms fall within the scope limited by the appended claims of the application equally.
[0048] Example 1
[0049] Take 20g of Magnolia officinalis flower, 150g of bamboo shoots, 40g of Bletilla striata, 60g of Cistanche deserticola, 10g of Aloe vera, 40g of Prunus mume, 40g of Rosa laevigata, 60g of Astragalus, and 40g of Angelica sinensis. Preparation method:
[0050] (1) Soaking Magnolia officinalis flower, Bletilla striata, Cistanche deserticola, Aloe vera, Prunus mume, Rosa laevigata, Astragalus membranaceus, and Angelica sinensis in water, wherein the amount of water added for the first soaking is 8 times the weight of the medicinal materials, and the soaking is for 0.5 h. The amount of water added for the second soaking is 6 times the weight of the medicinal materials. The first decoction is for 45 minutes, and the second decoction is for 30 minutes. The two decoctions are combined and concentrated to obtain a concentrated solution;
[0051] (2) preparing bamboo shoot liquid: soaking bamboo shoots in water, wherein the amount of water added is 20 times the weight of the bamboo shoots, taking the soaked bamboo shoots, adding water, blending in a homogenizer, filtering, preparing a homogenate, and concentrating to obtain bamboo shoot liquid;
[0052] (3) The concentrated solution obtained in step (1) is mixed evenly with the bamboo shoot solution obtained in step (2) to prepare a decoction.
[0053] Example 2
[0054] Take 10g of Magnolia officinalis flower, 225g of bamboo shoots, 20g of Bletilla striata, 90g of Cistanche deserticola, 5g of Aloe vera, 60g of Prunus mume, 20g of Rosa laevigata, 90g of Astragalus, and 20g of Angelica sinensis. Preparation method:
[0055] (1) Soaking Magnolia officinalis flower, Bletilla striata, Cistanche deserticola, Aloe vera, Prunus mume, Rosa laevigata, Astragalus membranaceus, and Angelica sinensis in water, wherein the amount of water added for the first soaking is 8 times the weight of the medicinal materials, and the soaking is for 0.5 h. The amount of water added for the second soaking is 6 times the weight of the medicinal materials. The first decoction is for 45 minutes, and the second decoction is for 30 minutes. The two decoctions are combined and concentrated to obtain a concentrated solution;
[0056] (2) preparing bamboo shoot liquid: soaking bamboo shoots in water, wherein the amount of water added is 20 times the weight of the bamboo shoots, taking the soaked bamboo shoots, adding water, blending in a homogenizer, filtering, preparing a homogenate, and concentrating to obtain bamboo shoot liquid;
[0057] (3) The concentrated solution obtained in step (1) is mixed evenly with the bamboo shoot solution obtained in step (2), and spray-dried to obtain granules.
[0058] Example 3
[0059] Take 30g of Magnolia officinalis flower, 75g of bamboo shoots, 60g of Bletilla striata, 30g of Cistanche deserticola, 20g of Aloe vera, 20g of Prunus mume, 60g of Rosa laevigata, 30g of Astragalus, and 60g of Angelica sinensis. Preparation method:
[0060] (1) Soaking Magnolia officinalis flower, Bletilla striata, Cistanche deserticola, Aloe vera, Prunus mume, Rosa laevigata, Astragalus membranaceus, and Angelica sinensis in water, wherein the amount of water added for the first soaking is 8 times the weight of the medicinal materials, and the soaking is for 0.5 h. The amount of water added for the second soaking is 6 times the weight of the medicinal materials. The first decoction is for 45 minutes, and the second decoction is for 30 minutes. The two decoctions are combined and concentrated to obtain a concentrated solution;
[0061] (2) preparing bamboo shoot liquid: soaking bamboo shoots in water, wherein the amount of water added is 20 times the weight of the bamboo shoots, taking the soaked bamboo shoots, adding water, blending in a homogenizer, filtering, preparing a homogenate, and concentrating to obtain bamboo shoot liquid;
[0062] (3) The concentrated solution obtained in step (1) is mixed evenly with the bamboo shoot solution obtained in step (2) to prepare a decoction.
[0063] Example 4
[0064] A method for preparing a medicinal chicken comprises the steps of slaughtering and cleaning the chicken, decocting, sterilizing, freezing, and packaging for refrigeration. The specific steps are as follows:
[0065] (1) Slaughtering chickens: Select healthy live chickens with a lifespan of more than one year and slaughter them, and clean them thoroughly;
[0066] (2) decoction: put the cleaned chicken into the medicinal meal package of claim 1 and an appropriate amount of seasoning, add water and decoct for 1 hour, the weight of the Chinese medicine contained in the medicinal meal package being 1 / 5 of the weight of the chicken;
[0067] (3) Sterilization: The boiled chicken is placed in a sterilization box and sterilized with the aid of 2500 Hz ultrasonic waves, so that the temperature in the sterilization box is maintained at 100° C. for 7 minutes;
[0068] (4) Freezing: Cooling for 50 minutes at a relative humidity of 85%, a wind speed of 4 m / s, a cooling temperature of -20°C, and an ultrasonic wave of 2500 Hz;
[0069] (5)Package and refrigerate.
[0070] Example 5
[0071] A method for preparing a medicinal duck comprises the steps of slaughtering the duck, cleaning it, boiling it, sterilizing it, freezing it, and packaging it for refrigeration. The specific steps are as follows:
[0072] (1) Slaughtering ducks: Select healthy live ducks with a lifespan of more than one year for slaughter and clean them thoroughly;
[0073] (2) decoction: put the cleaned duck into the medicinal meal package of claim 1 and an appropriate amount of seasoning, add water and decoct for 1 hour, the weight of the Chinese medicine contained in the medicinal meal package is 1 / 5 of the weight of the duck;
[0074] (3) Sterilization: The boiled duck is placed in a sterilization box and sterilized with the aid of 2800 Hz ultrasonic waves, with the temperature in the sterilization box maintained at 100°C for 8 minutes;
[0075] (4) Freezing: Cooling for 40 minutes at a relative humidity of 90%, a wind speed of 3 m / s, a cooling temperature of -20°C, and an ultrasonic wave of 2800 Hz;
[0076] (5)Package and refrigerate.
[0077] Example 6: Functional studies
[0078] 1. Determine the dosage for mice: Take the decoction prepared in Example 1 above, concentrate it to an extract equivalent to 15g of raw drugs per ml, and use it as a medicated meal package for the high-dose group; concentrate it to an extract equivalent to 7.5g of raw drugs per ml, and use it as a medicated meal package for the medium-dose group; concentrate it to an extract equivalent to 3.75g of raw drugs per ml, and use it as a medicated meal package for the low-dose group.
[0079] 2. Animals: ICR mice, provided by Qinglongshan Experimental Animal Center. Age: 7-8 weeks; Weight: 23-25 g; Gender: male.
[0080] 3. Construction of hyperlipidemia model: After 3 days of adaptive feeding, mice were fed with a high-fat diet and intragastrically administered with fat emulsion for hyperlipidemia modeling. High-fat diet was purchased from Qinglongshan Experimental Animal Center. Fat emulsion was prepared according to Table 1. Preparation method: lard was placed in a 500mL beaker and heated on an electric stove to melt, cholesterol was added and melted, sodium cholate and propylthiouracil tablets were added, stirred thoroughly, and then an appropriate amount of distilled water and Tween 80 were added, stirred continuously, and double distilled water was added to 200mL and mixed thoroughly. 0.2mL / 20g mouse / day was intragastrically administered daily.
[0081] Table 1 Fat emulsion preparation method
[0082] Material Dosage lard 40g cholesterol 20g Sodium Cholate 4g Propylthiouracil Tablets 2g Twain 80 40mL Pure water to volume 200mL
[0083] 4. Experimental process: ICR mice were selected, and the untreated group was set as the blank group; the rest of the mice were subjected to hyperlipidemia model building, and were divided into the blank group, model group, low-dose group, medium-dose group, and high-dose group according to whether the drug meal package was given. The oral volume of the low-, medium-, and high-dose drug meal packages was 10mL / kg. The model group was given an equal dose of normal saline. The drug meal package was given for 30 days.
[0084] 5. Observation indicators
[0085] 5.1 Body weight, recorded every 2 days using a body weight scale;
[0086] 5.2 Intestinal propulsion rate detection: Mice that had fasted for one day were divided into a blank group, a model group, a low-dose group, a medium-dose group, and a high-dose group, and the drugs were administered by gavage according to the dose of the drug meal package. Then, 0.1 mL / 10 g of ink solution was gavaged to the five groups of animals respectively. The animals were killed by cervical dislocation 30 minutes after the administration, and the whole intestinal tube from the pylorus to the end was immediately dissected and taken out, and laid flat on filter paper. The distance from the front of the ink to the pylorus and the total length of the small intestine were measured under tension-free conditions, and the small intestinal propulsion rate was finally calculated. Small intestinal propulsion rate / % = distance from the front of the ink to the pylorus / total length of the small intestine × 100%.
[0087] 5.3 After the experiment, blood was collected and the animals were killed. The serum was used to analyze the hyperlipidemia indicators, including total cholesterol, triglycerides and low-density lipoprotein cholesterol, using a biochemical analyzer. The kits were purchased from Zhejiang Qiangsheng Biotechnology Co., Ltd.
[0088] 6. Data statistics and analysis: All data were expressed as mean ± SD or expressed as mean ± SD. The inter-group differences were analyzed using Prism 8.0. P < 0.05 was considered statistically significant.
[0089] 7. Results and Conclusions
[0090] Weight loss effect: Weight gain as a risk factor for hyperlipidemia (Table 2, Figure 1), the results showed that the high-dose group of medicated meal packs significantly inhibited the weight gain of mice in the model group.
[0091] Table 2 Effects of high, medium and low doses of medicated diet packages on the body weight of mice (mean ± SD)
[0092] Group Blank group Model Group Low dose Medium dose High dose Weight (g) 28.53±0.50 33.77±0.72** 33.67±2.76 29.67±0.68* 28.67±1.95*
[0093] *P<0.05, **P<0.01, compared with the model group.
[0094] Intestinal health effects: In order to detect the effect of the medicated diet package on the intestine, the propulsion rate of ink in the intestine of mice was counted, and it was found that the high and medium dose medicated diet package significantly promoted the peristalsis of the intestine of mice and promoted the movement of the contents (Table 3, Figure 2 ).
[0095] Table 3 Effects of high, medium and low doses of medicated diet packages on intestinal propulsion rate of mice (mean±SD)
[0096] Group Blank group Model Group Low dose Medium dose High dose Advancement rate (%) 56.20±2.59 44.43±8.62 57.17±10.54 58.73±12.90* 67.97±7.07**
[0097] *P<0.05, **P<0.01, compared with the model group.
[0098] Inhibition of hyperlipidemia-related indicators: Further, the effects of high and medium doses on the levels of total cholesterol, low-density lipoprotein cholesterol and triglycerides in mice were tested (Table 4, Figure 3-5 ), and found that high and medium doses can significantly reduce the levels of the above three indicators.
[0099] Table 4 Effects of high, medium and low doses of medicated diet packages on hyperlipidemia-related indicators in mice (mean±SD)
[0100]
[0101]
[0102] *P<0.05, **P<0.01, ****P<0.0001 compared with the corresponding model groups of each index.
[0103] In summary, the high, medium and low dose groups of the medicated diet pack have the effect of resisting hyperlipidemia, and therefore have the efficacy of preventing cardiovascular and cerebrovascular diseases.
[0104] The above embodiments further elaborate and illustrate a lipid-lowering medicated diet package and a preparation method thereof disclosed in the present invention. The description of the above embodiments is only used to help understand the method and its core idea of the present application. For those skilled in the art, according to the idea of the present application, there may be changes in the specific implementation method and application scope. The content of this specification should not be understood as a limitation on the present application.
Claims
1. A medicated diet package having the effect of regulating blood lipids, characterized in that: The medicated meal package is prepared by extracting the following Chinese medicinal raw materials: magnolia officinalis flower, bamboo shoots, bletilla striata, cistanche deserticola, aloe vera, Prunus mume seeds, Rosa laevigata fruit, astragalus, and angelica sinensis.
2. The medicated diet package having the effect of regulating blood lipids according to claim 1, characterized in that: The Chinese medicinal materials are mixed in the following weight proportions: 1-3 parts of magnolia officinalis flowers, 7.5-22.5 parts of bamboo shoots, 2-6 parts of white ginseng, 3-9 parts of cistanche deserticola, 0.5-2 parts of aloe, 2-6 parts of prunus mume seeds, 2-6 parts of rosa laevigata fruits, 3-9 parts of astragalus, and 2-6 parts of angelica.
3. The medicated diet package having the effect of regulating blood lipids according to claim 2, characterized in that: The Chinese medicinal materials are mixed in the following weight proportions: 2 parts of Magnolia officinalis flower, 15 parts of bamboo shoots, 4 parts of Bletilla striata, 6 parts of Cistanche deserticola, 1 part of Aloe vera, 4 parts of Prunus mume seeds, 4 parts of Rosa laevigatae, 6 parts of Astragalus, and 4 parts of Angelica sinensis.
4. The medicated diet package having the effect of regulating blood lipids according to claim 1, characterized in that: The preparation method comprises the following steps: (1) soaking Magnolia officinalis flower, Bletilla striata, Cistanche deserticola, Aloe vera, Prunus mume, Rosa laevigata, Astragalus membranaceus and Angelica sinensis in water, decocting for the first time, filtering, adding water, decocting for the second time, combining the two decoctions, filtering and concentrating to obtain a concentrated solution; (2) preparing bamboo shoot liquid: soaking bamboo shoots in water, homogenizing and filtering to obtain bamboo shoot liquid; (3) mixing the concentrated solution obtained in step (1) and the bamboo shoot liquid obtained in step (2) evenly, concentrating and obtaining a solid product or a liquid product.
5. The medicated diet package having the effect of regulating blood lipids according to claim 4, characterized in that: In the preparation method, the amount of water added for soaking is 8 times the weight of the medicinal materials, and the soaking is 0.5 hours. The amount of water added for the second decoction is 6 times the weight of the medicinal materials. The first decoction is 45 minutes, and the second decoction is 30 minutes.
6. The medicated diet package having the effect of regulating blood lipids according to claim 4, characterized in that: In the preparation method, the amount of water added for soaking the bamboo shoots is 20 times the weight of the bamboo shoots.
7. The medicated diet package having the effect of regulating blood lipids according to claim 4, characterized in that: In the preparation method, the solid form product is a granule, and the liquid form product is a decoction.
8. Use of the medicated diet package having the effect of regulating blood lipids according to claim 1 in preparing health food for inhibiting hyperlipidemia.
9. A method for preparing medicinal chicken, characterized in that: The steps include slaughtering and cleaning the chicken, frying, boiling, sterilizing, freezing, packaging and refrigerating. The specific steps are as follows: (1) Slaughtering chickens: Select healthy live chickens with a lifespan of more than one year and slaughter them, and clean them thoroughly; (2) decoction: put the cleaned chicken into the medicinal meal package of claim 1 and an appropriate amount of seasoning, add water and decoct for 1 hour, the weight of the Chinese medicine contained in the medicinal meal package being 1 / 5 of the weight of the chicken; (3) Sterilization: Put the boiled chicken into a sterilization box and sterilize it with the help of 2000-3000 Hz ultrasound, so that the temperature in the sterilization box is maintained at 80-100° C. for 5-8 minutes; (4) Freezing: Cooling for 40-60 minutes at a relative humidity of 80%-90%, a wind speed of 3-5 m / s, a cooling temperature of -20°C, and an ultrasonic wave of 2000-3000 Hz; (5)Package and refrigerate.
10. A method for preparing a medicinal duck, characterized in that: The steps include taking the duck, slaughtering, cleaning, boiling, sterilizing, freezing and packaging for refrigeration. The specific steps are as follows: (1) Slaughtering ducks: Select healthy live ducks with a lifespan of more than one year for slaughter and clean them; (2) decoction: put the cleaned duck into the medicinal meal package of claim 1 and an appropriate amount of seasoning, add water and decoct for 1 hour, the weight of the Chinese medicine contained in the medicinal meal package is 1 / 5 of the weight of the duck; (3) Sterilization: Place the boiled duck in a sterilization box and sterilize it with the aid of 2000-3000 Hz ultrasonic waves, keeping the temperature in the sterilization box at 80-100° C. for 5-8 minutes; (4) Freezing: Cooling for 40-60 minutes at a relative humidity of 80%-90%, a wind speed of 3-5 m / s, a cooling temperature of -20°C, and an ultrasonic wave of 2000-3000 Hz; (5)Package and refrigerate.
Citation Information
Patent Citations
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