Rafoxanide suspension and preparation method thereof

Abstract

The invention discloses a rafoxanide suspension and a preparation method thereof, and relates to the field of stirring, and the rafoxanide suspension comprises rafoxanide, sodium alginate, dimethyl silicone oil and Tween-80. The mass ratio of the rafoxanide to the sodium alginate is (100: 1)-(5: 1); 1 to 10 kg of the rafoxanide is contained in each 100 L of the suspension medicine. A rotating shaft rotates a second conical tooth to rotate, the second conical tooth drives third conical teeth to rotate, two sets of third conical teeth rotate to drive a first conical gear to rotate in a reciprocating mode, the first conical gear drives a sliding block to rotate through a transmission column, and the sliding block drives a feeding pipe to slide in a sliding groove in a reciprocating mode. Furthermore, the ingredients fall at different positions of the tank body when entering the tank body from the feeding pipe, and the mixing effect can be improved during stirring.

Description

Technical Field

[0001] The invention relates to the field of stirring, in particular to an iodine ether salamide suspension and a preparation method thereof. Background Art

[0002] Iodine ether thiocarbamide suspension has a killing effect mainly on the adult worms of Fasciola hepatica and Fasciola gigantea, and also has high activity against immature worms.

[0003] The production method for suspension drugs with patent number CN111821260B proposes that after dispersing iodine ether salamide in a Tween solution, soybean oil, dimethyl silicone oil and benzyl alcohol are added, and after stirring evenly, a sodium alginate solution is added, and the mixture is mixed again to obtain a mixed solution; a citric acid solution and a sodium citrate solution are added to the mixed solution, and then the mixed solution is homogenized at a pressure of 30 MPa; water is added to the mixed solution after homogenization to a set volume, and the pH value is adjusted to 5.5-5.8 to obtain the suspension drug.

[0004] However, in the preparation of the current iodine ether salamide suspension and its preparation method, the positions for adding multiple drugs are fixed at the same place, which makes the overall density mixing speed slow, resulting in a slow mixing homogenization rate. Summary of the invention

[0005] Based on this, the purpose of the present invention is to provide a iodine ether salamide suspension and a preparation method thereof, so as to solve the technical problem that the addition positions of multiple agents are fixed at the same place, resulting in a slow overall density mixing speed and a slow mixing homogenization rate.

[0006] To achieve the above object, the present invention provides the following technical scheme: a iodine ether salamide suspension, comprising iodine ether salamide, sodium alginate, dimethyl silicone oil, and Tween-80; the mass ratio of iodine ether salamide to sodium alginate is 100:1-5:1; and 1-10 kg of iodine ether salamide is contained in every 100 L of the suspension drug.

[0007] The present invention is further configured as follows: the preparation method is as follows: a mixing module is used to add a plurality of raw materials batch by batch for mixing and homogenization under a pressure of 30 MPa.

[0008] The present invention is further configured such that the mixing module includes a base, a tank body is arranged above the base, a rotating motor is installed at the middle position of the bottom of the tank body, and a rotating shaft is connected to the output end of the rotating motor, a second mounting seat is fixed to the bottom end of the outer side of the rotating shaft, a limiting column is fixed to the top of the rotating shaft, and a material balancing mechanism is fixed to the top of the limiting column;

[0009] The material equalizing mechanism includes a connecting seat, both sides of the connecting seat are rotatably connected with a fixed shaft, and the end of the fixed shaft is rotatably connected with a third conical tooth, both sides of the connecting seat are provided with a transmission seat, the head end of the fixed shaft is connected with a first transmission tooth, the top end of the connecting seat is rotatably connected with the first conical tooth, and a transmission column that penetrates to the outside of the connecting seat is fixed at the middle position of the top of the first conical tooth, and the top of the limiting column is fixed with a second conical tooth that penetrates to the inside of the connecting seat, a sliding groove is provided at the top of the outer side of the tank body, and a sliding block is slidably connected to the inside of the sliding groove, and a feeding pipe is provided inside the sliding block, and the sliding block is connected to the transmission column.

[0010] The present invention is further configured such that both the first conical teeth and the second conical teeth are meshed with the third conical teeth, and the first conical teeth are semicircular teeth.

[0011] The present invention is further configured such that the transmission seat is internally rotatably connected with a sleeve that penetrates to the outside of the transmission seat, and the top of the sleeve is fixed with a second transmission tooth that meshes with the first transmission tooth, the sleeve is internally slidably connected with a stud, and a bidirectional screw groove is provided on the outside of the stud, a limiting column is fixed to the bottom of the stud, the bottom of the limiting column is rotatably connected with a limiting ball, and the bottom end of the inner wall of the stud is provided with a fixing block that cooperates with the bidirectional screw groove.

[0012] The present invention is further configured such that the outer side of the limiting column is slidably connected to a first mounting seat, and the top of the first mounting seat is provided with a limiting groove that cooperates with the limiting ball, and the bottom of the connecting seat is fixed with a limiting frame that cooperates with the limiting column, and the cross-section of the limiting column is rectangular.

[0013] The present invention is further configured such that a second mounting seat is fixed to the bottom end of the outer side of the rotating shaft, and stirring blades are arranged on the outer sides of the second mounting seat and the first mounting seat.

[0014] The present invention is further configured such that sealing plates are provided on both sides of the sliding block, and movable grooves cooperating with the sealing plates are provided on both sides of the sliding groove, a glass window is provided on the front surface of the tank body, a cover plate is provided on the top of the tank body, and a discharge port is provided on one side of the bottom of the tank body, and fixing frames are fixed at both ends of the connecting seat.

[0015] In summary, the present invention mainly has the following beneficial effects:

[0016] 1. The present invention drives the rotating shaft to rotate by means of a rotating motor, the rotating shaft rotates the second conical gear to rotate, the second conical gear drives the third conical gear to rotate, the two sets of third conical gears rotate, drive the first conical gear to reciprocate, the first conical gear drives the sliding block to rotate through the transmission column, the sliding block drives the feed pipe to slide back and forth inside the sliding groove, so that the ingredients fall at different positions of the tank body when entering the tank body from the feed pipe, and the mixing effect can be improved during stirring;

[0017] 2. The present invention drives the fixed shaft to rotate by rotating the third conical tooth, the fixed shaft drives the first transmission tooth to rotate, the first transmission tooth drives the second transmission tooth to rotate, the second transmission tooth drives the sleeve to rotate, when the sleeve rotates, the purpose of reciprocating up and down movement of the stud is achieved under the action of the mutual cooperation of the bidirectional screw groove and the fixed block. At this time, the stud drives the first mounting seat to move up and down, and at the same time, the first mounting seat drives the stirring blade to rotate. The two methods are combined to improve the stirring method, thereby improving the stirring effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0019] Figure 2 It is a schematic diagram of the internal structure of the present invention;

[0020] Figure 3 is an internal cross-sectional view of the present invention;

[0021] Figure 4 It is an enlarged view of A of the present invention;

[0022] Figure 5 It is a structural schematic diagram of the connecting socket of the present invention;

[0023] Figure 6 This is a schematic diagram of the internal connection of the connection socket of the present invention;

[0024] Figure 7 It is a schematic diagram of the internal structure of the transmission seat of the present invention.

[0025] In the figure: 1. tank body; 2. base; 3. rotating motor; 4. sliding groove; 5. sliding block; 6. feeding pipe; 7. glass window; 8. connecting seat; 801. first conical tooth; 802. fixed shaft; 803. second conical tooth; 804. third conical tooth; 9. fixed frame; 10. stirring blade; 11. limiting column; 12. first mounting seat; 13. blocking plate; 14. rotating shaft; 15. second mounting seat; 16. transmission column; 17. limiting groove; 18. limiting column; 19. limiting frame; 20. sleeve; 21. transmission seat; 22. limiting ball; 23. bidirectional screw groove; 24. first transmission tooth; 25. second transmission tooth; 26. fixing block; 27. stud. DETAILED DESCRIPTION

[0026] The following will be combined with the accompanying drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0027] The following describes an embodiment of the present invention based on its overall structure.

[0028] A suspension of iodine ether salamide, such as Figure 1-7 As shown, it includes iodine ether sulfonamide, sodium alginate, dimethyl silicone oil, and Tween-80; the mass ratio of iodine ether sulfonamide to sodium alginate is 100:1-5:1; in every 100L of suspension medicine, 1-10kg of iodine ether sulfonamide is contained; the preparation method is as follows: a mixing module is used to add multiple raw materials batch by batch under a pressure of 30mpa for mixing and homogenization.

[0029] A variety of ingredients are added through a mixing module, and the various ingredients are mixed under a pressure of 30 MPa to form an iodine ether salamide suspension.

[0030] It should be pointed out that the mixing module includes a base 2, a tank body 1 is arranged above the base 2, and a rotating motor 3 is installed at the middle position of the bottom of the tank body 1, and the output end of the rotating motor 3 is connected to a rotating shaft 14, a second mounting seat 15 is fixed to the bottom end of the outer side of the rotating shaft 14, and a limiting column 11 is fixed to the top of the rotating shaft 14, and a material balancing mechanism is fixed to the top of the limiting column 11; the material balancing mechanism includes a connecting seat 8, both sides of the connecting seat 8 are rotatably connected with a fixed shaft 802, and the end of the fixed shaft 802 is rotatably connected with a third conical tooth 804, both sides of the connecting seat 8 are provided with a transmission seat 21, the head end of the fixed shaft 802 is connected with a first transmission tooth 24, the top end of the connecting seat 8 is rotatably connected with a first conical tooth 801, and the first conical tooth 802 is rotatably connected to the first conical tooth 801. A transmission column 16 penetrating to the outside of the connecting seat 8 is fixed at the middle position of the top of the tooth 801, and a second conical tooth 803 penetrating to the inside of the connecting seat 8 is fixed on the top of the limiting column 11. A sliding groove 4 is provided at the top of the outer side of the tank body 1, and a sliding block 5 is slidably connected inside the sliding groove 4, and a feed pipe 6 is provided inside the sliding block 5. The sliding block 5 is connected to the transmission column 16, and the transmission column 16 drives the sliding block 5 to move. The first conical tooth 801 and the second conical tooth 803 are both meshed with the third conical tooth 804. The first conical tooth 801 is a semicircular tooth. The first conical gear 801 with semicircular teeth is intermittently meshed with the second conical tooth 803 and the third conical tooth 804 respectively, so as to realize the reciprocating rotation of the first conical tooth 801.

[0031] In this embodiment: the rotating motor 3 is set to drive the rotating shaft 14 to rotate, the rotating shaft 14 rotates the second bevel gear 803 to rotate, the second bevel gear 803 drives the third bevel gear 804 to rotate, the two groups of third bevel gears 804 rotate, and drive the first bevel gear 801 to reciprocate, the first bevel gear 801 drives the sliding block 5 to rotate through the transmission column 16, and the sliding block 5 drives the feed pipe 6 to slide back and forth inside the sliding groove 4, so that the ingredients fall at different positions of the tank body 1 when entering the tank body 1 from the feed pipe 6, which can improve the mixing effect during stirring.

[0032] See also Figure 3 , Figure 4 , Figure 5 and Figure 7 The transmission seat 21 is internally rotatably connected with a sleeve 20 that penetrates the outside of the transmission seat 21, and the top of the sleeve 20 is fixed with a second transmission tooth 25 that meshes with the first transmission tooth 24, the sleeve 20 is internally slidably connected with a stud 27, and the outer side of the stud 27 is provided with a bidirectional screw groove 23, the bottom of the stud 27 is fixed with a limiting column 18, the bottom of the limiting column 18 is rotatably connected with a limiting ball 22, the outer side of the limiting column 11 is slidably connected with the first mounting seat 12, and

[0033] A limiting groove 17 cooperating with the limiting ball 22 is provided on the top of the first mounting seat 12, and a limiting frame 19 cooperating with the limiting column 18 is fixed to the bottom of the connecting seat 8, and the limiting ball 22 is clamped so that the first mounting seat 12 moves with the stud 27. A fixing block 26 cooperating with the bidirectional screw groove 23 is provided at the bottom end of the inner wall of the stud 27. The cross-section of the limiting column 18 is rectangular, and the rectangular limiting column 18 cooperates with the limiting frame 19 to prevent the limiting column 18 from rotating. A second mounting seat 15 is fixed to the bottom end of the outer side of the rotating shaft 14, and stirring blades 10 are provided on the outer sides of the second mounting seat 15 and the first mounting seat 12 for stirring.

[0034] It can be understood that the third conical tooth 804 rotates to drive the fixed shaft 802 to rotate, the fixed shaft 802 drives the first transmission tooth 24 to rotate, the first transmission tooth 24 drives the second transmission tooth 25 to rotate, and the second transmission tooth 25 drives the sleeve 20 to rotate. When the sleeve 20 rotates, the two-way screw groove 23 and the fixed block 26 cooperate with each other to achieve the purpose of reciprocating up and down movement of the stud 27. At this time, the stud 27 drives the first mounting seat 12 to move up and down, and at the same time, the first mounting seat 12 drives the stirring blade 10 to rotate. The two methods are combined to improve the stirring method.

[0035] Thereby improving the stirring effect.

[0036] See also Figure 1 and Figure 2, sealing plates 13 are provided on both sides of the sliding block 5 to seal the sliding groove 4, and moving grooves that cooperate with the sealing plates 13 are provided on both sides of the sliding groove 4 to facilitate the sliding of the sealing plates 13 in the moving grooves, and a glass window 7 is provided on the front surface of the tank body 1 to facilitate viewing the stirring effect inside the tank body 1, and a cover plate is provided on the top of the tank body 1 to cooperate with the sealing of the tank body 1 to facilitate the completion of the 30 MPa pressure, and a discharge port is provided on one side of the bottom of the tank body 1, and a valve is provided inside the discharge port, and fixing frames 9 are fixed at both ends of the connecting seat 8.

[0037] It should be noted that the cover plate is used to seal the interior of the tank 1, and the blocking plate 13 moves with the sliding block 5, and cooperates with the moving groove to seal the tank body 1 to facilitate the adjustment of the internal air pressure of the tank body 1.

[0038] The glass window 7 is used to facilitate viewing of the stirring effect inside the tank body 1 .

[0039] Although an embodiment of the present invention has been shown and described, this specific embodiment is merely an explanation of the present invention and is not a limitation of the invention. The specific features, structures, materials or characteristics described may be combined in a suitable manner in any one or more embodiments or examples. After reading this specification, those skilled in the art may make modifications, substitutions and variations to the embodiments without creative contributions as needed without departing from the principles and purpose of the present invention. However, as long as they are within the scope of the claims of the present invention, they are protected by patent law.

Claims

1. A iodine ether salamide suspension, characterized in that: The invention comprises iodine ether sulfonamide, sodium alginate, dimethyl silicone oil and Tween-80; the mass ratio of iodine ether sulfonamide to sodium alginate is 100:1-5:1; and each 100L of the suspension medicine contains 1-10kg of iodine ether sulfonamide.

2. A method for preparing an iodine ether salamide suspension, applied to an iodine ether salamide suspension as claimed in any one of claim 1, characterized in that: The preparation method is as follows: a mixing module is used to add a variety of raw materials batch by batch and mix them homogeneously under a pressure of 30 MPa.

3. A method for preparing a iodine ether salamide suspension according to claim 2, characterized in that: The mixing module comprises a base (2), a tank body (1) is arranged above the base (2), a rotating motor (3) is installed at the middle position of the bottom of the tank body (1), and the output end of the rotating motor (3) is connected to a rotating shaft (14), a second mounting seat (15) is fixed to the bottom end of the outer side of the rotating shaft (14), a limiting column (11) is fixed to the top of the rotating shaft (14), and a material balancing mechanism is fixed to the top of the limiting column (11); The material distribution mechanism comprises a connecting seat (8), both sides of the connecting seat (8) are rotatably connected with a fixed shaft (802), and the end of the fixed shaft (802) is rotatably connected with a third conical tooth (804), both sides of the connecting seat (8) are provided with a transmission seat (21), the head end of the fixed shaft (802) is connected with a first transmission tooth (24), the top end of the connecting seat (8) is rotatably connected with the first conical tooth (801), and a transmission column (16) penetrating to the outside of the connecting seat (8) is fixed at the middle position of the top of the first conical tooth (801), the top of the limiting column (11) is fixed with a second conical tooth (803) penetrating to the inside of the connecting seat (8), the top of the outer side of the tank body (1) is provided with a sliding groove (4), and the inside of the sliding groove (4) is slidably connected with a sliding block (5), and the inside of the sliding block (5) is provided with a feeding pipe (6), and the sliding block (5) is connected to the transmission column (16).

4. A method for preparing a iodine ether salamide suspension according to claim 3, characterized in that: The first conical teeth (801) and the second conical teeth (803) are both meshed with the third conical teeth (804), and the first conical teeth (801) are semicircular teeth.

5. The method for preparing a iodine ether salamide suspension according to claim 3, wherein: The transmission seat (21) is internally rotatably connected with a sleeve (20) extending through the outside of the transmission seat (21), and a second transmission tooth (25) meshing with the first transmission tooth (24) is fixed on the top of the sleeve (20), a stud (27) is slidably connected inside the sleeve (20), and a bidirectional screw groove (23) is arranged on the outer side of the stud (27), a limiting column (18) is fixed at the bottom of the stud (27), and the bottom of the limiting column (18) is rotatably connected with a limiting ball (22), and a fixing block (26) cooperating with the bidirectional screw groove (23) is arranged at the bottom end of the inner wall of the stud (27).

6. A method for preparing a iodine ether salamide suspension according to claim 5, characterized in that: The outer side of the limiting column (11) is slidably connected to a first mounting seat (12), and the top of the first mounting seat (12) is provided with a limiting groove (17) that cooperates with a limiting ball (22), and the bottom of the connecting seat (8) is fixed with a limiting frame (19) that cooperates with the limiting column (18), and the cross-section of the limiting column (18) is rectangular.

7. A method for preparing a iodine ether salamide suspension according to claim 6, characterized in that: A second mounting seat (15) is fixed to the bottom end of the outer side of the rotating shaft (14), and stirring blades (10) are arranged on the outer sides of the second mounting seat (15) and the first mounting seat (12).

8. A method for preparing a iodine ether salamide suspension according to claim 3, characterized in that: Sealing plates (13) are provided on both sides of the sliding block (5), and movable grooves cooperating with the sealing plates (13) are provided on both sides of the interior of the sliding groove (4), a glass window (7) is provided on the front surface of the tank body (1), a cover plate is provided on the top of the tank body (1), and a discharge port is provided on one side of the bottom of the tank body (1), and fixing frames (9) are fixed at both ends of the connecting seat (8).

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