Externally-coated hydrogel for promoting wound healing and preparation device of externally-coated hydrogel

Abstract

The invention relates to the technical field of hydrogel preparation, and discloses a pan dragon jade externally-coated hydrogel for promoting wound healing and a preparation device thereof.The pan dragon jade externally-coated hydrogel comprises an extraction mechanism, a reaction mechanism and a forming mechanism, the extraction mechanism comprises an extraction tank, and a mashing bin, an extraction bin and a heating bin are arranged on the upper portion, the middle portion and the lower portion in the extraction tank respectively; the reaction mechanism comprises a reaction tank arranged on the right side of the extraction tank, a second feeding port is formed in the top of the outer wall of the right side of the reaction tank, the forming mechanism comprises a forming tank arranged on the right side of the reaction tank, and a third feeding port is formed in the top of the outer wall of the left side of the forming tank; the second discharging port and the third feeding port are directly connected with a second liquid conveying pipe. According to the pan dragon jade externally-coated hydrogel for promoting wound healing and the preparation device of the pan dragon jade externally-coated hydrogel, large-particle impurities can be removed, the purity of an extracting solution can be guaranteed, effective components can be efficiently extracted, meanwhile, the quality and stability of a hydrogel precursor are guaranteed, and a user can use the hydrogel conveniently.

Description

Technical Field

[0001] The invention relates to the technical field of hydrogel preparation, and in particular to a Panlong jade externally coated hydrogel for promoting wound healing and a preparation device thereof. Background Art

[0002] Hydrogel is a gel with water as the dispersion medium. A part of hydrophobic groups and hydrophilic residues are introduced into the water-soluble polymer with a network cross-linked structure. Due to its unique physical and chemical properties, it is widely used in biomedicine, drug delivery, tissue engineering and other fields. The use of Panlong jade raw material extract to prepare Panlong jade external hydrogel that promotes wound healing is based on its excellent biocompatibility, safety and multiple functions of promoting wound healing, and has broad application prospects.

[0003] Many preparation devices on the market lack effective crushing and screening steps when processing Panlong jade raw materials, resulting in the inability to effectively remove large particle impurities in the raw materials, which not only affects the purity of the extract, but may also affect the quality and stability of the final hydrogel. At the same time, when the extract is mixed with the reactant, there is a lack of corresponding stirring equipment, resulting in uneven mixing reaction, insufficient local reaction or uneven reaction, thereby affecting the quality and consistency of the hydrogel precursor. Therefore, a Panlong jade external coating hydrogel for promoting wound healing and a preparation device thereof are proposed to solve the above problems. Summary of the invention

[0004] 1. Technical issues to be solved

[0005] In view of the deficiencies in the prior art, the present invention provides a Panlong jade externally coated hydrogel for promoting wound healing and a preparation device thereof, which has the advantages of efficient preparation of hydrogels, etc., and solves the problem that many preparation devices on the market lack effective crushing and screening steps when processing Panlong jade raw materials, resulting in the inability to effectively remove large particle impurities in the raw materials, which not only affects the purity of the extract, but may also affect the quality and stability of the final hydrogel. At the same time, when the extract is mixed with the reactant, there is a lack of corresponding stirring equipment, resulting in uneven mixing reaction, insufficient local reaction or uneven reaction, thereby affecting the quality and consistency of the hydrogel precursor.

[0006] (II) Technical solution

[0007] In order to achieve the above-mentioned purpose of efficiently preparing hydrogel, the present invention provides the following technical solutions:

[0008] A panlong jade externally applied hydrogel for promoting wound healing, comprising raw materials of panlong jade extract, sodium hyaluronate, glycerin, an antibacterial agent, a solubilizer and water, which are stirred and mixed to form a gel;

[0009] The Panlong jade external coating hydrogel comprises the following components by mass: 3-5 parts of Panlong jade extract, 5-8 parts of sodium hyaluronate, 2-4 parts of glycerol, 1-2 parts of antibacterial agent, 2-5 parts of solubilizer, and 5-8 parts of water.

[0010] A preparation device for a Panlong jade externally coated hydrogel for promoting wound healing, comprising an extraction mechanism, a reaction mechanism and a molding mechanism, wherein the reaction mechanism is arranged on the right side of the extraction mechanism, and the molding mechanism is arranged on the right side of the reaction mechanism;

[0011] The extraction mechanism comprises an extraction tank, wherein a crushing chamber, an extraction chamber, and a heating chamber are respectively arranged at the top, middle, and bottom of the extraction tank, a first feed port is arranged at both the left and right sides of the top of the extraction tank, a discharge port is arranged at the left outer wall of the extraction chamber, and a first discharge port is arranged at the right outer wall of the extraction chamber;

[0012] The reaction mechanism comprises a reaction tank arranged on the right side of the extraction tank, a second feed port is provided at the top of the right outer wall of the reaction tank, a first infusion pipe is connected between the first discharge port on the extraction bin and the second feed port on the reaction tank, a pump is provided in the middle of the first infusion pipe, and a second discharge port is provided at the bottom of the reaction tank;

[0013] The molding mechanism comprises a molding tank arranged on the right side of the reaction tank, a third feed port is provided on the top of the left outer wall of the molding tank, and a second infusion tube is directly connected to the second discharge port and the third feed port.

[0014] As a preferred technical solution of the present invention, a crushing motor is arranged in the middle of the top of the extraction tank, and the output shaft at the bottom of the crushing motor is connected to a rotating rod, and the rotating rod is arranged inside the crushing bin.

[0015] As a preferred technical solution of the present invention, two pairs of mounting rods are sleeved on the outer wall surface of the rotating rod, and crushing plates are fixedly mounted on the surfaces of the mounting rods.

[0016] As a preferred technical solution of the present invention, a screen frame is arranged between the crushing bin and the extraction bin, the screen frame is inserted into the inner wall of the extraction tank, the left part of the screen frame penetrates the left inner wall of the extraction tank, a handle is fixedly installed on the left outer wall of the screen frame, and a screen is fixedly installed in the middle of the screen frame.

[0017] As a preferred technical solution of the present invention, the extraction chamber and the heating chamber are directly provided with heat conducting plates, a fuel adding port is provided at the bottom of the front end outer wall of the extraction tank, and the fuel adding port is connected to the heating chamber.

[0018] As a preferred technical solution of the present invention, a stirring motor is fixedly installed on the top of the reaction tank, and a stirring rod is connected to the output shaft at the bottom of the stirring motor. The stirring rod is arranged inside the reaction tank, and two mounting blocks are sleeved on the outer wall surface of the stirring rod. Stirring plates are fixedly installed on both ends of the left and right ends of the mounting blocks.

[0019] As a preferred technical solution of the present invention, a reactant adding tank is arranged on the right side of the outer wall of the reaction tank, two connecting rods are fixedly connected between the reactant adding tank and the outer wall of the reaction tank, an adding pipe is connected between the top of the reactant adding tank and the top of the right outer wall of the reaction tank, and a small pump is arranged on the surface of the adding pipe.

[0020] As a preferred technical solution of the present invention, a scale window is provided on the outer wall surface of the front end of the molding tank, a discharge pipe is inserted into the top of the right outer wall of the molding tank, and a valve is provided on the surface of the discharge pipe.

[0021] (III) Beneficial effects

[0022] Compared with the prior art, the present invention provides a Panlongyu externally coated hydrogel for promoting wound healing and a preparation device thereof, which has the following beneficial effects:

[0023] 1. The Panlong jade external hydrogel for promoting wound healing and its preparation device, by setting the mutual cooperation of the crushing bin and the sieve frame, the preparation device can fully crush and effectively screen the Panlong jade raw material, remove large particle impurities, and ensure the purity of the extract. At the same time, the design of the heating bin enables the solvent to efficiently extract the effective ingredients at a suitable temperature, thereby improving the extraction efficiency and quality.

[0024] 2. The Panlongyu external hydrogel for promoting wound healing and its preparation device, through the combination of a stirring motor, a stirring rod and a stirring plate configured in a reaction tank, ensures sufficient mixing and uniform reaction of the extract and the reactant during the reaction process, avoids the problem of uneven local reaction or insufficient reaction, thereby improving the quality and stability of the hydrogel precursor.

[0025] 3. The Panlongyu externally coated hydrogel for promoting wound healing and its preparation device, through the scale window design on the molding tank, enable the operator to intuitively observe the molding process of the hydrogel and adjust the process parameters in time to ensure the quality and output of the product. In addition, the setting of the valve also facilitates the removal and subsequent processing of the finished product. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a schematic diagram of the structure of the present invention;

[0027] Figure 2 This is a schematic diagram of the interior of the extraction tank in the present invention;

[0028] Figure 3 It is a schematic diagram of a crushing motor in the present invention;

[0029] Figure 4 This is a schematic diagram of the interior of the reaction tank in the present invention;

[0030] Figure 5 It is a schematic diagram of the molding tank in the present invention.

[0031] In the figure: 1. extraction tank; 2. crushing bin; 3. extraction bin; 4. heating bin; 5. first feed port; 6. discharge port; 7. first discharge port; 8. reaction tank; 9. second feed port; 10. first infusion pipe; 11. pump; 12. second discharge port; 13. forming tank; 14. third feed port; 15. second infusion pipe; 16. crushing motor; 17. rotating rod; 18. mounting rod; 19. crushing plate; 20. screen frame; 21. screen; 22. heat transfer plate; 23. fuel addition port; 24. stirring motor; 25. stirring rod; 26. mounting block; 27. stirring sheet; 28. reactant addition tank; 29. ​​connecting rod; 30. addition pipe; 31. small pump; 32. scale window; 33. discharge pipe; 34. valve. DETAILED DESCRIPTION

[0032] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0033] In the description of the present invention, it should be understood that the terms "center", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship are based on the orientation or position relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0034] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a direct connection, or an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0035] A panlong jade externally applied hydrogel for promoting wound healing, comprising raw materials of panlong jade extract, sodium hyaluronate, glycerin, an antibacterial agent, a solubilizer and water, which are stirred and mixed to form a gel;

[0036] The Panlong jade external coating hydrogel includes the following components by mass percentage: 3-5 parts of Panlong jade extract, 5-8 parts of sodium hyaluronate, 2-4 parts of glycerol, 1-2 parts of antibacterial agent, 2-5 parts of solubilizer, and 5-8 parts of water.

[0037] See also Figure 1-5 A device for preparing a Panlong jade externally coated hydrogel for promoting wound healing comprises an extraction mechanism, a reaction mechanism and a molding mechanism. The reaction mechanism is arranged on the right side of the extraction mechanism, and the molding mechanism is arranged on the right side of the reaction mechanism.

[0038] In this embodiment, the extraction mechanism includes an extraction tank 1, and a crushing bin 2, an extraction bin 3, and a heating bin 4 are respectively arranged at the top, middle, and bottom of the extraction tank 1. A first feed port 5 is arranged on both sides of the top of the extraction tank 1. A discharge port 6 is opened on the left outer wall of the extraction bin 3, and a first discharge port 7 is opened on the right outer wall of the extraction bin 3.

[0039] It should be noted that the extraction tank 1, as the core container of the entire extraction process, provides the spatial environment required for crushing, extraction and heating. The crushing bin 2 is located above the inside of the extraction tank 1 and is used for preliminary processing of the Panlong jade raw material. It reduces the particle size of the raw material by crushing to prepare for the subsequent extraction process. The extraction bin 3 is located below the crushing bin 2 and is used to receive the crushed raw material and perform solvent extraction to obtain effective ingredients. The heating bin 4 is located below the extraction bin 3 and promotes the extraction of effective ingredients in the raw material by the solvent by heating the extraction bin 3, thereby improving the extraction efficiency.

[0040] In this embodiment, the reaction mechanism includes a reaction tank 8 arranged on the right side of the extraction tank 1, and a second feed port 9 is provided at the top of the right outer wall of the reaction tank 8. A first infusion pipe 10 is connected between the first discharge port 7 on the extraction chamber 3 and the second feed port 9 on the reaction tank 8. A pump 11 is provided in the middle of the first infusion pipe 10, and a second discharge port 12 is provided at the bottom of the reaction tank 8.

[0041] It should be noted that the reaction tank 8 is located on the right side of the extraction tank 1, and is used to receive the extract and add reactants for mixing reaction to generate a hydrogel precursor. The second feed port 9 is used to receive the extract from the extraction chamber 3, and the pump 11 provides power to pump the extract from the extraction chamber 3 to the reaction tank 8.

[0042] In this embodiment, the molding mechanism includes a molding tank 13 arranged on the right side of the reaction tank 8. A third feed port 14 is opened on the top of the left outer wall of the molding tank 13. The second discharge port 12 and the third feed port 14 are directly connected to a second infusion tube 15.

[0043] It should be noted that the molding tank 13 is used to receive the hydrogel precursor and solidify it into shape by cooling, the third feed port 14 is used to receive the hydrogel precursor from the reaction tank 8, and the second infusion tube 15 connects the second discharge port 12 of the reaction tank 8 and the third feed port 14 of the molding tank 13, and is used to transport the hydrogel precursor.

[0044] In this embodiment, a crushing motor 16 is arranged in the middle of the top of the extraction tank 1 , and the output shaft at the bottom of the crushing motor 16 is connected to a rotating rod 17 , and the rotating rod 17 is arranged inside the crushing bin 2 .

[0045] It should be noted that the crushing motor 16 provides power to drive the rotating rod 17 to rotate, thereby driving the crushing plate 19 to crush the raw materials. The rotating rod 17 is connected to the bottom output shaft of the crushing motor 16 and is arranged inside the crushing bin 2, driving the crushing plate 19 to work by rotating.

[0046] In this embodiment, two pairs of mounting rods 18 are sleeved on the outer wall surface of the rotating rod 17 , and crushing plates 19 are fixedly mounted on the surface of the mounting rods 18 .

[0047] It should be noted that the mounting rod 18 is used to fix the crushing plate 19, and the crushing plate 19 crushes the raw materials by rotating.

[0048] In this embodiment, a screen frame 20 is provided between the crushing bin 2 and the extraction bin 3. The screen frame 20 is inserted into the inner wall of the extraction tank 1. The left part of the screen frame 20 penetrates the left inner wall of the extraction tank 1. A handle is fixedly installed on the left outer wall of the screen frame 20, and a screen 21 is fixedly installed in the middle of the screen frame 20.

[0049] It should be noted that the sieve frame 20 is used to intercept large particles of impurities to ensure the purity of the extract, and the screen 21 is fixed in the middle of the sieve frame 20 to perform a screening function.

[0050] In this embodiment, the extraction chamber 3 and the heating chamber 4 are directly provided with a heat conducting plate 22 , and a fuel adding port 23 is opened at the bottom of the front end outer wall of the extraction tank 1 , and the fuel adding port 23 is connected to the heating chamber 4 .

[0051] It should be noted that the heat conducting plate 22 transfers heat to enable the heating chamber 4 to heat the extraction chamber 3 , and the fuel adding port 23 is used to add fuel to the heating chamber 4 to generate heat.

[0052] In this embodiment, a stirring motor 24 is fixedly installed on the top of the reaction tank 8, and a stirring rod 25 is connected to the output shaft at the bottom of the stirring motor 24. The stirring rod 25 is arranged inside the reaction tank 8. Two mounting blocks 26 are sleeved on the outer wall surface of the stirring rod 25, and stirring plates 27 are fixedly installed on both ends of the left and right ends of the mounting blocks 26.

[0053] It should be noted that the stirring motor 24 provides power to drive the stirring rod 25 to rotate, and the stirring rod 25 drives the stirring blade 27 to perform a mixing reaction through rotation, and the mounting block 26 is used to fix and install the stirring blade 27.

[0054] In this embodiment, a reactant adding tank 28 is provided on the right side of the outer wall of the reaction tank 8, two connecting rods 29 are fixedly connected between the reactant adding tank 28 and the outer wall of the reaction tank 8, an adding pipe 30 is connected between the top of the reactant adding tank 28 and the top of the right outer wall of the reaction tank 8, and a small pump 31 is provided on the surface of the adding pipe 30.

[0055] It should be noted that the reactant adding tank 28 is used to store reactants, the connecting rod 29 is fixedly connected to the reactant adding tank 28 and the outer wall of the reaction tank 8 to play a supporting role, and the adding pipe 30 adds the reactant to the reaction tank 8 through a small pump 31.

[0056] In this embodiment, a scale window 32 is opened on the outer wall surface of the front end of the molding tank 13, a discharge pipe 33 is inserted into the top of the right outer wall of the molding tank 13, and a valve 34 is provided on the surface of the discharge pipe 33.

[0057] It should be noted that the scale window 32 is used to observe the forming process of the hydrogel, the discharge pipe 33 is used to take out the hydrogel after curing and forming, and the valve 34 controls the opening and closing of the discharge pipe 33 to facilitate the taking out of the finished hydrogel.

[0058] Preparation working principle: first, put the Panlong jade raw materials and other auxiliary materials to be extracted into the crushing bin 2 through the first feed port 5, start the crushing motor 16, drive the rotating rod 17 and the crushing plate 19 thereon to rotate, and fully crush the raw materials in the crushing bin 2 to make them reach a suitable particle size. The crushed raw materials enter the extraction bin 3 through the screen frame 20, and the screen 21 intercepts large particles of impurities to ensure the purity of the extract. According to needs, add a proper amount of solvent into the extraction bin 3, heat it through the heating bin 4, and extract the effective ingredients. After the extraction is completed, turn on the pump 11, and pump the extract in the extraction bin 3 to the second feed port 9 of the reaction tank 8 through the first infusion tube 10;

[0059] In the reaction tank 8, according to the formula requirements, the reactant is added through the reactant adding tank 28 and the small pump 31 on the adding pipe 30, and the stirring motor 24 is started to drive the stirring rod 25 and the stirring blade 27 to rotate, so that the extract and the reactant are fully mixed and reacted to form the required hydrogel precursor. The hydrogel precursor after the reaction is completed is introduced into the molding tank 13 through the second infusion tube 15. In the molding tank 13, the hydrogel is solidified and formed by natural cooling or additional cooling equipment. The molding process can be observed through the scale window 32. After the hydrogel is completely solidified, the valve 34 on the discharge pipe 33 is opened to take out the finished hydrogel for packaging and quality inspection.

[0060] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A panlong jade external hydrogel for promoting wound healing, comprising panlong jade extract, sodium hyaluronate, glycerin, an antibacterial agent, a solubilizer and water, which are stirred and mixed to form a gel; Features: The Panlong jade external coating hydrogel comprises the following components by mass: 3-5 parts of Panlong jade extract, 5-8 parts of sodium hyaluronate, 2-4 parts of glycerol, 1-2 parts of antibacterial agent, 2-5 parts of solubilizer, and 5-8 parts of water.

2. A preparation device for a Panlong jade externally coated hydrogel for promoting wound healing, which is used to prepare the Panlong jade externally coated hydrogel for promoting wound healing as described in claim 1, comprising an extraction mechanism, a reaction mechanism and a molding mechanism, wherein the reaction mechanism is arranged on the right side of the extraction mechanism, and the molding mechanism is arranged on the right side of the reaction mechanism; Features: The extraction mechanism comprises an extraction tank (1), wherein a crushing chamber (2), an extraction chamber (3) and a heating chamber (4) are respectively arranged at the top, middle and bottom of the extraction tank (1), a first feed port (5) is arranged on both the left and right sides of the top of the extraction tank (1), a discharge port (6) is arranged on the left outer wall of the extraction chamber (3), and a first discharge port (7) is arranged on the right outer wall of the extraction chamber (3); The reaction mechanism comprises a reaction tank (8) arranged on the right side of the extraction tank (1), a second feed port (9) is provided at the top of the right outer wall of the reaction tank (8), a first liquid infusion pipe (10) is connected between the first discharge port (7) on the extraction chamber (3) and the second feed port (9) on the reaction tank (8), a pump (11) is provided in the middle of the first liquid infusion pipe (10), and a second discharge port (12) is provided at the bottom of the reaction tank (8); The molding mechanism comprises a molding tank (13) arranged on the right side of the reaction tank (8), a third feed port (14) is provided on the top of the left outer wall of the molding tank (13), and the second discharge port (12) and the third feed port (14) are directly connected to a second infusion pipe (15).

3. The device for preparing a Panlongyu externally coated hydrogel for promoting wound healing according to claim 2, characterized in that: A crushing motor (16) is arranged in the middle of the top of the extraction tank (1), and the output shaft at the bottom of the crushing motor (16) is connected to a rotating rod (17), and the rotating rod (17) is arranged inside the crushing bin (2).

4. The device for preparing the Panlongyu externally coated hydrogel for promoting wound healing according to claim 3, characterized in that: Two pairs of mounting rods (18) are sleeved on the outer wall surface of the rotating rod (17), and crushing plates (19) are fixedly mounted on the surfaces of the mounting rods (18).

5. The device for preparing the Panlongyu externally coated hydrogel for promoting wound healing according to claim 2, characterized in that: A screen frame (20) is provided between the crushing bin (2) and the extraction bin (3); the screen frame (20) is plugged into the inner wall of the extraction tank (1); the left side portion of the screen frame (20) penetrates the left inner wall of the extraction tank (1); a handle is fixedly mounted on the left outer wall of the screen frame (20); and a screen (21) is fixedly mounted in the middle of the screen frame (20).

6. The device for preparing the Panlongyu externally coated hydrogel for promoting wound healing according to claim 2, characterized in that: The extraction chamber (3) and the heating chamber (4) are directly provided with a heat conduction plate (22); the bottom of the front end outer wall of the extraction tank (1) is provided with a fuel addition port (23); and the fuel addition port (23) is connected to the heating chamber (4).

7. The device for preparing the Panlongyu externally coated hydrogel for promoting wound healing according to claim 2, characterized in that: A stirring motor (24) is fixedly mounted on the top of the reaction tank (8); a stirring rod (25) is connected to the output shaft at the bottom of the stirring motor (24); the stirring rod (25) is arranged inside the reaction tank (8); two mounting blocks (26) are sleeved on the outer wall surface of the stirring rod (25); stirring blades (27) are fixedly mounted on both left and right ends of the mounting block (26).

8. The device for preparing the Panlongyu externally coated hydrogel for promoting wound healing according to claim 2, characterized in that: A reactant adding tank (28) is arranged on the right side of the outer wall of the reaction tank (8), two connecting rods (29) are fixedly connected between the reactant adding tank (28) and the outer wall of the reaction tank (8), an adding pipe (30) is connected between the top of the reactant adding tank (28) and the top of the right outer wall of the reaction tank (8), and a small pump (31) is arranged on the surface of the adding pipe (30).

9. The device for preparing the Panlongyu externally coated hydrogel for promoting wound healing according to claim 2, characterized in that: A scale window (32) is provided on the front outer wall surface of the molding tank (13), a discharge pipe (33) is plugged into the top of the right outer wall of the molding tank (13), and a valve (34) is provided on the surface of the discharge pipe (33).

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