Pulse ablation operation system and method for pulmonary arterial hypertension

Abstract

The invention provides a pulse ablation operation system for pulmonary arterial hypertension, which comprises an intravascular 3D (three-dimensional) ultrasonic imaging module, an ablation operation planning module and a pulse ablation module, virtual operation planning is performed through information interaction among the modules, and a high-precision and high-efficiency pulmonary arterial hypertension pulse ablation operation is completed; the operation method based on the system comprises the following steps: S1) importing an intravascular 3D ultrasonic image model; s2) acquiring image data of the pulmonary artery and adjacent tissues thereof; s3) based on the image data, calculating a pulmonary artery wall narrow area, determining a pulse ablation depth, and virtualizing an operation plan; s4) calculating the surgical path constraint and the stress condition of the blood vessel wall to assess the surgical risk; after the pulmonary artery stenosis is simulated to be improved, predicting blood flow improvement; the method has the advantages that systematic virtual operation planning is achieved, images are complete and clear, data are fed back in real time and can be adjusted, precision and efficiency are improved, surrounding tissue damage is avoided, and operation comfort is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a pulse ablation system and method for pulmonary hypertension. Background Art

[0002] Pulmonary hypertension refers to a clinical and pathophysiological syndrome caused by changes in pulmonary vascular structure or function due to a variety of heterogeneous diseases (etiologies) and different pathogenic mechanisms, resulting in increased pulmonary vascular resistance and pulmonary artery pressure. Pulmonary hypertension is clinically divided into five categories: (1) arterial pulmonary hypertension; (2) pulmonary hypertension caused by left heart disease; (3) pulmonary hypertension caused by lung disease and / or hypoxia; (4) pulmonary hypertension caused by chronic thromboembolic pulmonary hypertension and / or other pulmonary artery obstructive lesions; and (5) pulmonary hypertension caused by unknown and / or multiple factors.

[0003] Autonomic nervous regulation affects vascular blood flow and local neuroendocrine system regulation. Idiopathic pulmonary hypertension is a type of vascular disease that mainly affects pulmonary arterioles. The main characteristics of progressive increase in pulmonary artery pressure are changes in cardiopulmonary circulation hemodynamics, pulmonary artery vascular remodeling, right heart hypertrophy, and functional failure. The gold standard for the diagnosis of pulmonary hypertension is a mean pulmonary artery pressure of ≥20 mmHg measured by right cardiac catheter at sea level and at rest, with a pulmonary artery wedge pressure of ≤15 mmHg and a pulmonary vascular resistance of >2 Wood units. Exercise pulmonary hypertension is defined as a difference in mPAP / CO between calm and active states of >3 mmHg / L / min. Studies have shown that stretch receptors are distributed at the bifurcation of the pulmonary arteries of normal humans. These receptors regulate pulmonary artery pressure through a negative feedback mechanism to produce vasoconstriction and vascular remodeling, and the sympathetic nerve excitement that promotes pulmonary hypertension is associated with pulmonary artery vasoconstriction and vascular remodeling. Animal experiments have shown that the pulmonary artery pressure of mammals can be significantly changed after local damage or intervention in the integrity and function of the sympathetic nerves of the pulmonary artery. In terms of human trials, the results of small multicenter clinical trials have shown the effectiveness and safety of pulmonary artery radiofrequency ablation in patients with pulmonary hypertension, and that this treatment significantly improves patients' activity tolerance, as manifested by reduced pulmonary vascular resistance, increased 6-minute walking distance, and improved daily activity ability.

[0004] Although studies have confirmed the effectiveness of pulmonary artery radiofrequency ablation technology for pulmonary hypertension, the current high-voltage pulse ablation surgery is not mature enough, the surgical accuracy and postoperative effects are not ideal, there is also a risk of damaging surrounding tissues, there is no systematic surgical planning, and lack of data feedback during the operation makes it difficult to adjust the ablation parameters. The quality of surgical images also needs to be further improved. Summary of the invention

[0005] The purpose of the present invention is to provide a pulse ablation surgery system and method for pulmonary hypertension with systematic virtual surgery planning, complete and clear images, real-time data feedback and adjustment, improved accuracy and efficiency, avoidance of surrounding tissue damage, and enhanced surgical comfort.

[0006] In order to achieve the above object, the present invention is implemented by the following technical solutions: A pulse ablation surgery system for pulmonary hypertension, comprising an intravascular 3D ultrasound imaging module, an ablation surgery planning module, and a pulse ablation module; The intravascular 3D ultrasonic imaging module includes an ultrasonic imaging system and a 3D system. The ultrasonic imaging system collects image data through a circular array ultrasonic probe and generates ultrasonic images through an ultrasonic focused imaging algorithm. The 3D system collects coordinate positions through a magnetic positioning 3D sensor, thereby constructing a 3D ultrasonic imaging model in the blood vessel. The ablation surgery planning module plans a virtual surgery including pulmonary hypertension target area calibration, path navigation, vessel wall force prediction, and blood flow improvement prediction by analyzing the imported 3D ultrasound image model; The pulse ablation module includes a central processing unit, a detection system, a pulse generator and a pulse positioning ablation catheter. The optimized and iterated virtual surgical plan is transmitted to the central processing unit. The central processing unit controls the pulse generator to generate pulse energy. The pulse positioning ablation catheter has a built-in circular array ultrasound probe, a magnetic positioning 3D sensor, a contact force sensor and an ablation electrode and integrates multiple functions of ultrasound detection, magnetic positioning, path navigation, contact force detection, ablation treatment and impedance acquisition. The pulse positioning ablation catheter transmits contact force data and impedance data to the detection system. The detection system detects the contact force data and impedance data and transmits them to the central processing unit and the ablation surgery planning module respectively.

[0007] A pulse ablation surgical method for pulmonary hypertension, comprising the following steps: Step S1) importing the intravascular 3D ultrasound image model; Step S2) acquiring image data of the pulmonary artery and its adjacent tissues; Step S3) based on the image data, calculating the stenosis area of ​​the pulmonary artery wall and determining the pulse ablation depth, and virtual surgery planning; Step S4) calculating the surgical path constraints and the stress on the vascular wall to assess the surgical risk; after simulating the improvement of pulmonary artery stenosis, predicting the improvement of blood flow; Step S5) Outputting the surgical plan and performing the surgery.

[0008] Compared with the prior art, the present invention has the following advantages: The present invention provides a pulse ablation surgery system and method for pulmonary hypertension, which integrates an intravascular 3D ultrasound imaging module, an ablation surgery planning module, and a pulse ablation module. The system can generate a detailed surgical plan report including surgical steps, ablation parameters, potential risks, and expected effects, and provide doctors with comprehensive surgical guidance, thereby improving the success rate of surgery, reducing surgical risks, and improving the quality of life of patients. Specifically, the system integrates auxiliary tools for medical image integrated analysis, virtual surgery planning, and fluid dynamics simulation, and is used to treat vascular diseases such as pulmonary artery stenosis; based on pulmonary artery imaging data, the system can accurately calculate the stenosis area and determine the appropriate pulse ablation depth; in a virtual surgical environment, doctors can adjust the ablation parameters to observe the results of the virtual surgery, and the system will calculate the surgical path constraints and the stress of the vascular wall to evaluate the surgical risks; the system can also simulate the blood flow after the improvement of pulmonary hypertension to predict the surgical effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0009] Figure 1 It is a schematic diagram of the system module of the present invention.

[0010] Figure 2 It is a schematic diagram of the ablation surgical method of the present invention. DETAILED DESCRIPTION

[0011] The embodiments of the present invention are described in further detail below in conjunction with the accompanying drawings.

[0012] like Figure 1 As shown, a pulse ablation surgery system for pulmonary hypertension includes an intravascular 3D ultrasound imaging module, an ablation surgery planning module, and a pulse ablation module.

[0013] The intravascular 3D ultrasound imaging module includes an ultrasound imaging system and a 3D system. The ultrasound imaging system acquires image data through a circular array ultrasound probe and generates ultrasound images through an ultrasound focused imaging algorithm. Specifically, the circular array ultrasound probe is built into the pulse positioning ablation catheter of the pulse ablation module. The circular array ultrasound probe transmits ultrasound signals to human tissues and receives echo sound signals of different intensities reflected by human tissues. The 3D system acquires coordinate positions through a magnetic positioning 3D sensor, and the magnetic positioning 3D sensor is built into the pulse positioning ablation catheter of the pulse ablation module. The ultrasound image and coordinate position acquisition data are fitted in 3D ultrasound space to construct a 3D ultrasound imaging model in the blood vessel.

[0014] The ablation surgery planning module plans virtual surgery including pulmonary hypertension target area calibration, path navigation, vessel wall force prediction, and blood flow improvement prediction by processing data from the imported 3D ultrasound image model, thereby generating an automatic surgery plan.

[0015] The pulse ablation module includes a central processing unit, a detection system, a pulse generator and a pulse positioning ablation catheter. The optimized and iterated virtual surgical plan is transmitted to the central processing unit. The central processing unit controls the pulse generator to generate pulse energy according to the virtual surgical plan and releases the pulse energy through the pulse positioning ablation catheter. The pulse positioning ablation catheter has a built-in circular array ultrasound probe, a magnetic positioning 3D sensor, a contact force sensor and an ablation electrode and integrates multiple functions of ultrasound detection, magnetic positioning, path navigation, contact force detection, ablation treatment and impedance acquisition. The pulse positioning ablation catheter transmits contact force data and impedance data to the detection system while performing pulse ablation. The detection system detects the contact force data and impedance data and transmits them to the central processing unit and the ablation surgery planning module respectively, so as to further adjust the ablation parameters in the virtual surgical plan to adapt to the current surgery.

[0016] like Figure 2 As shown, a pulse ablation surgical method for pulmonary hypertension includes the following steps: Step S1) importing the intravascular 3D ultrasound image model; Step S2) acquiring image data of the pulmonary artery and its adjacent tissues; Step S3) based on the image data, calculating the stenosis area of ​​the pulmonary artery wall and determining the pulse ablation depth, and virtual surgery planning; Step S4) calculating the surgical path constraints and the stress on the vascular wall to assess the surgical risk; after simulating the improvement of pulmonary artery stenosis, predicting the improvement of blood flow; Step S5) Outputting the surgical plan and performing the surgery.

[0017] The above description is only a preferred embodiment of the present invention. It should be pointed out that ordinary technicians in this technical field can make several improvements and modifications without departing from the concept of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A pulse ablation surgical system for pulmonary hypertension, characterized in that: Including intravascular 3D ultrasound imaging module, ablation surgery planning module, and pulse ablation module; The intravascular 3D ultrasonic imaging module includes an ultrasonic imaging system and a 3D system. The ultrasonic imaging system collects image data through a circular array ultrasonic probe and generates ultrasonic images through an ultrasonic focused imaging algorithm. The 3D system collects coordinate positions through a magnetic positioning 3D sensor, thereby constructing a 3D ultrasonic imaging model in the blood vessel. The ablation surgery planning module plans a virtual surgery including pulmonary hypertension target area calibration, path navigation, vessel wall force prediction, and blood flow improvement prediction by analyzing the imported 3D ultrasound image model; The pulse ablation module includes a central processing unit, a detection system, a pulse generator and a pulse positioning ablation catheter. The optimized and iterated virtual surgical plan is transmitted to the central processing unit. The central processing unit controls the pulse generator to generate pulse energy. The pulse positioning ablation catheter has a built-in circular array ultrasound probe, a magnetic positioning 3D sensor, a contact force sensor and an ablation electrode and integrates multiple functions of ultrasound detection, magnetic positioning, path navigation, contact force detection, ablation treatment and impedance acquisition. The pulse positioning ablation catheter transmits contact force data and impedance data to the detection system. The detection system detects the contact force data and impedance data and transmits them to the central processing unit and the ablation surgery planning module respectively.

2. A pulse ablation surgical method for pulmonary hypertension, characterized in that The steps include: Step S1) importing the intravascular 3D ultrasound image model; Step S2) acquiring image data of the pulmonary artery and its adjacent tissues; Step S3) based on the image data, calculating the stenosis area of ​​the pulmonary artery wall and determining the pulse ablation depth, and virtual surgery planning; Step S4) calculating the surgical path constraints and the stress on the vascular wall to assess the surgical risk; after simulating the improvement of pulmonary artery stenosis, predicting the improvement of blood flow; Step S5) Outputting the surgical plan and performing the surgery.

Images