Device system for detecting concentration of coupling gas in real time in reagent preparation and use method of device system

Abstract

The invention provides a device system for detecting the concentration of coupling gas in reagent preparation in real time and a use method of the device system. The device system comprises a box body, a fluorinated gas storage device, a vacuum system, a re-pressing system, a hydraulic system, a detection system and a control system, a hydraulic system and a detection system are arranged in the box body, and a plurality of open containers are placed in a containing cavity in the box body; the hydraulic system is used for pressing a first sealing component on the open container; the detection system comprises at least two infrared detection devices, and the infrared detection devices are arranged in the accommodating cavity; the infrared detection device is used for detecting the concentration of fluorinated gas in the box body; and the fluorinated gas storage device is communicated with the gas inlet of the box body through a first pipeline. According to the invention, automatic preparation of corresponding reagents can be carried out, the purity of the reagents can be improved, the concentration of fluorinated gas in the box body can be detected in real time, and whether the fluorinated gas in the box body has enough negative pressure resistance can be determined.

Description

Technical Field

[0001] The invention belongs to the technical field of medicament preparation and gas detection, and relates to a device system for real-time detection of reagent preparation coupled with gas concentration and a use method thereof. Background Art

[0002] Octafluoropropane is a colorless, odorless, non-flammable gas commonly used in the pharmaceutical, electric power and other industries. For example, octafluoropropane can be prepared into lipid microsphere injections and used as ultrasound contrast agents. This contrast agent is mainly used to enhance the backscattering of ultrasound signals and improve the clarity of ultrasound images. However, most of the existing preparation methods use manual syringe ventilation methods, and the concentration and purity of the prepared microsphere injections are not high, and human factors also have a great impact on the results. Therefore, providing a reagent preparation device system with a simple structure and a high degree of automation is a problem that technicians in this field urgently need to solve.

[0003] In addition, there is no mature solution for the technology of testing the negative pressure resistance of octafluoropropane gas in the box in the domestic and foreign industries. In the pharmaceutical industry, in order to ensure the safe operation of the equipment, it is necessary to regularly test whether the octafluoropropane gas in the equipment has sufficient negative pressure resistance. If the negative pressure resistance of the gas in the box is insufficient, it may cause gas leakage, which will affect the normal operation of the equipment and even cause safety accidents.

[0004] However, although there are many ways to detect the pressure of a gas or the presence of a specific gas, such as inferring the gas's ability to withstand negative pressure through pressure sensors or air tightness tests, they cannot directly reflect the specific performance of octafluoropropane gas under negative pressure conditions, and are affected by environmental factors. There are large errors in actual applications, resulting in inaccurate and unreliable test results. Some researchers evacuate the box into a vacuum state and then observe gas leakage over a period of time, but this process is usually time-consuming and not conducive to rapid diagnosis and maintenance. Alternatively, laboratory chemical analysis is performed after collecting samples, but the entire process is time-consuming and cannot achieve real-time monitoring.

[0005] The solutions provided by the existing technology have many problems in the negative pressure resistance of octafluoropropane gas in the detection box, including low detection accuracy, long test cycle, high equipment complexity, large environmental interference, limited scope of application, difficult data processing, high maintenance cost and safety issues. These problems limit the practical application effect of the existing technology and urgently need new technological breakthroughs and improvements. This is mainly because the special properties of octafluoropropane gas make it difficult for traditional detection methods to adapt.

[0006] Therefore, a new technology that can accurately detect the negative pressure resistance of octafluoropropane gas in the box and automate the reagent preparation is developed to improve the accuracy and practicality of the detection and the purity of the reagent, which plays an extremely important role in the quality of drugs and safe production in the pharmaceutical industry. Summary of the invention

[0007] In view of the shortcomings of the prior art, the purpose of the present invention is to provide a device system for reagent preparation coupled with real-time detection of gas concentration and a method of using the same, which can not only automatically prepare the corresponding reagents, which is beneficial to improve the purity of the reagents, but also can detect the concentration of fluorinated gas in the box in real time, confirm whether the fluorinated gas in the box has sufficient negative pressure resistance, and avoid production interruptions or production accidents caused by excessive fluorinated gas concentration.

[0008] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0009] In a first aspect, the present invention provides a device system for real-time detection of reagent preparation coupled gas concentration, the device system comprising a box, a fluorinated gas storage device, a vacuum system, a re-pressurization system, a hydraulic system, a detection system and a control system;

[0010] The box is provided with a hydraulic system and a detection system.

[0011] A plurality of open containers are placed in the accommodating cavity in the box body;

[0012] The hydraulic system is used to compress the first sealing component on the open container;

[0013] The detection system comprises at least two infrared detection devices, and the infrared detection devices are arranged in the accommodating cavity;

[0014] The infrared detection device is used to detect the concentration of fluorinated gas in the box;

[0015] The fluorinated gas storage device is connected to the air inlet of the box through a first pipeline;

[0016] The vacuum system is used to form a negative pressure state in the containing chamber;

[0017] The pressure restoring system is used to restore the pressure in the containing chamber to normal pressure or slightly positive pressure;

[0018] The control system is used to control the start and stop of the vacuum system, the re-pressurization system and the hydraulic system, and monitor parameter changes in the infrared detection device.

[0019] In the present invention, the open container is filled with microbubble contrast agent or other reagents; the open container is placed before the accommodating cavity, and the first sealing component is pre-placed at the opening of the open container, but it is not completely sealed, that is, the first sealing component at the opening of the open container is in a semi-plug state; the fluorinated gas includes octafluoropropane.

[0020] The device system provided by the present invention, by arranging a hydraulic system and a detection system in the box body, combined with a matching vacuum system, a re-pressure system and a control system, can not only automatically prepare the corresponding reagents, which is beneficial to improving the purity of the reagents, but also can detect the concentration of the fluorinated gas in the box body in real time, confirm whether the fluorinated gas in the box body has sufficient negative pressure resistance, and avoid production interruptions or production accidents caused by excessive fluorinated gas concentration, thereby improving production efficiency. At the same time, the device system has high safety, simple structure, and is easy to use, and is suitable for popularization and use.

[0021] It is worth noting that when preparing the corresponding reagents, the vacuum system's vacuuming effect is used to ensure that the box is in a negative pressure state, and then the fluorinated gas is filled into the containing cavity and the corresponding open container, so as to prepare the corresponding volume of reagents as needed. When the concentration of the fluorinated gas reaches the production requirement, the inflation is stopped, and then the pressure in the containing cavity is restored by the re-pressurization system, and at the same time, the first sealing component on the open container is compressed by the hydraulic system to complete the preparation of the reagents. Finally, after the air in the box meets the standard, the open container is taken out for use.

[0022] It is worth mentioning that at least two infrared detection devices are arranged in the containing chamber, which not only eliminates the need for manual sampling and detection, thus reducing the chance of personnel being exposed to harmful gases, thereby improving the safety of operation, but also facilitates real-time detection of the concentration of fluorinated gas in the box, ensuring more accurate detection results, and facilitating precise control of the concentration of fluorinated gas in the box, ensuring that the fluorinated gas is always within a safe and ideal range, which is beneficial to improving product quality.

[0023] As a preferred technical solution of the present invention, the box body is a negative pressure resistant box body.

[0024] In the present invention, the material of the box body is a high-strength corrosion-resistant material, which ensures that the box body can maintain structural stability under both negative pressure and positive pressure conditions to avoid gas leakage.

[0025] Preferably, the box body consists of an upper cover plate, a lower bottom plate and four side wall plates.

[0026] Preferably, a first through hole is provided on the upper cover plate.

[0027] Preferably, a second through hole is provided on the lower base plate.

[0028] Preferably, the space formed between the upper cover plate and the lower base plate is a receiving cavity.

[0029] Preferably, an air inlet, a liquid discharge port and an air outlet are independently arranged on the box body.

[0030] In the present invention, a valve is provided on the liquid discharge port.

[0031] It should be noted that the present invention does not specifically limit the positions of the air inlet, the liquid discharge port and the exhaust port, and their positions can be flexibly changed according to needs. Those skilled in the art can make reasonable settings based on actual needs.

[0032] Preferably, avoidance grooves are provided at the first through hole, the second through hole and the air inlet.

[0033] In the present invention, in order to prevent the open container from tipping over due to excessive air pressure during vacuuming or re-pressurization, avoidance grooves are provided at the first through hole, the second through hole and the air inlet.

[0034] Preferably, the open container comprises a reagent bottle.

[0035] In the present invention, a first sealing component is placed at the opening of the open container.

[0036] Preferably, the first sealing component comprises a rubber plug.

[0037] As a preferred technical solution of the present invention, the exhaust port of the box is connected to the exhaust gas treatment device through a second pipeline.

[0038] Preferably, filtering components are provided on both the first pipeline and the second pipeline.

[0039] In the present invention, the filtering component includes a filter net.

[0040] Preferably, the first through hole is connected to the vacuum system through a third pipeline.

[0041] Preferably, the second through hole is connected to the pressure-recovering system via a fourth pipeline.

[0042] As a preferred technical solution of the present invention, the hydraulic system includes a hydraulic component and a first pressure regulating device which are connected in sequence.

[0043] In the present invention, in order to accurately control the pressure applied to the first sealing component and ensure that the applied pressure is evenly distributed, a first pressure regulating device is configured.

[0044] Preferably, the detection system comprises two infrared detection devices.

[0045] Preferably, the infrared detection device is arranged on two side wall plates arranged opposite to each other in the accommodating cavity.

[0046] Preferably, a supporting device is also provided in the box.

[0047] Preferably, the supporting device is used to support the infrared detection device.

[0048] As a preferred technical solution of the present invention, the vacuum system includes a vacuum device.

[0049] In the present invention, if the vacuum device used has the problem of air liquefaction in the box during the vacuuming process, causing water intrusion and damage to the vacuum pump, the vacuum system needs to further include a condensing device, which is connected to the vacuum device. This not only helps to improve the performance and efficiency of the vacuum system, but also prevents water vapor from condensing inside the vacuum device, which may cause damage to the vacuum equipment or inaccurate experimental results.

[0050] Preferably, the re-pressurization system comprises an inflation device and a second pressure regulating device which are connected in sequence.

[0051] In the present invention, in order to ensure the pressure control accuracy during the re-pressurization process, a second pressure regulating device is configured.

[0052] As a preferred technical solution of the present invention, the control system includes a PLC control system.

[0053] In the present invention, the coordinated work of each system is realized by designing an integrated control system. A PLC system is used for centralized control and data processing. The control system provides a friendly user interface, which is convenient for operators to monitor and adjust system parameters, and can realize remote monitoring and fault diagnosis functions.

[0054] Preferably, the PLC control system is connected to the vacuum system, the re-pressurization system, the hydraulic system and the detection system through control signals.

[0055] As a preferred technical solution of the present invention, the device system also includes a plurality of second sealing components and an alarm system.

[0056] Preferably, the second sealing component is independently arranged at the door shafts of the box body and the accommodating chamber.

[0057] In the present invention, by arranging the second sealing component at the door axis of the box body and the accommodating chamber, it is ensured that the air tightness of the box body is qualified under various pressure conditions.

[0058] Preferably, the second sealing component comprises a sealing ring.

[0059] Preferably, the PLC control system is connected to the alarm system via a control signal.

[0060] In the present invention, an alarm system is added to ensure that the power supply can be quickly cut off in abnormal situations to avoid production accidents.

[0061] In a second aspect, the present invention provides a method for using reagent preparation coupled with real-time detection of gas concentration, the method being performed using the device system described in the first aspect, comprising:

[0062] (1) The containing chamber is evacuated to a negative pressure state by a vacuum system, and then the fluorinated gas in the fluorinated gas storage device is charged into the containing chamber, and the fluorinated gas concentration in the containing chamber is monitored in real time by an infrared detection device. When the gas concentration reaches a set value required for production, the charging of the fluorinated gas is stopped by controlling the control system;

[0063] (2) The pressure in the containing chamber is restored to normal pressure or slightly positive pressure by using a re-pressurization system, and at the same time, the first sealing component on the open container is compressed by a hydraulic system and the concentration of the fluorinated gas in the containing chamber is monitored in real time by an infrared detection device, and then the open container is taken out.

[0064] As a preferred technical solution of the present invention, the fluorinated gas includes octafluoropropane.

[0065] As a preferred technical solution of the present invention, the pressure recovery method described in step (2) includes: using a vacuum system to extract the fluorinated gas in the containing chamber, and then using a re-pressurization system to fill air into the containing chamber to perform gas replacement. After the replacement is completed, an infrared detection device is used to detect whether the concentration of the fluorinated gas in the containing chamber meets the standard.

[0066] Compared with the prior art, the present invention has the following beneficial effects:

[0067] (1) The device system and the method of using the device system provided by the present invention, by providing a hydraulic system and a detection system in the box body, combined with a matching vacuum system, a re-pressurization system and a control system, can not only automatically prepare the corresponding reagents, which is beneficial to improving the purity of the reagents, but also can detect the concentration of the fluorinated gas in the box body in real time, confirm whether the fluorinated gas in the box body has sufficient negative pressure resistance, and avoid production interruptions or production accidents caused by excessive fluorinated gas concentration, thereby improving production efficiency;

[0068] (2) The device system provided by the present invention can effectively control the concentration and emission of fluorinated gases in the box, and does not require manual sampling and testing. It has high safety, no production pollution, simple overall structure, and is easy to use, and is suitable for popularization and use. BRIEF DESCRIPTION OF THE DRAWINGS

[0069] Figure 1 It is a simplified structural diagram of the device system for real-time detection of reagent preparation coupled gas concentration provided by the present invention;

[0070] Figure 2 is a schematic diagram of a control system in a device system provided by the present invention;

[0071] Figure 3 It is a schematic diagram of the structure of the device system for real-time detection of reagent preparation coupled gas concentration provided in Example 1;

[0072] Among them, 1-box, 2-accommodating chamber, 3-first through hole, 4-second through hole, 5-drain port, 6-air inlet, 7-exhaust port, 8-hydraulic system, 9-infrared detection device, 10-vacuum system, 11-re-pressurization system, 12-control system, 13-condensing device, 14-vacuum device. DETAILED DESCRIPTION

[0073] It should be noted that in the description of the present invention, unless otherwise clearly specified and limited, the terms "disposed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood by specific circumstances.

[0074] The technical solution of the present invention is further described below in conjunction with the accompanying drawings and through specific implementation methods. However, the following examples are only simplified examples of the present invention and do not represent or limit the scope of protection of the present invention. The scope of protection of the present invention shall be subject to the claims.

[0075] A specific embodiment of the present invention provides a device system for real-time detection of reagent preparation coupled with gas concentration. This embodiment provides a device system for real-time detection of reagent preparation coupled with gas concentration. The device system (such as Figure 1 ) includes a box 1, a fluorinated gas storage device, a vacuum system 10, a re-pressurization system 11, a hydraulic system 8, a detection system and a control system 12;

[0076] The box body 1 is composed of an upper cover plate, a lower bottom plate and four side wall plates; a first through hole 3 is provided on the upper cover plate; a drain port 5 and a second through hole 4 are independently provided on the lower bottom plate; a space formed between the upper cover plate and the lower bottom plate is a receiving cavity 3; an air inlet 6 is provided at the connection between the side wall plate and the upper cover plate; an air outlet 7 is provided at the connection between the side wall plate and the lower bottom plate; avoidance grooves are provided at the first through hole 3, the second through hole 4 and the air inlet 6;

[0077] The box 1 is provided with a hydraulic system 8 and a detection system, and a plurality of reagent bottles are placed in the accommodating chamber 2 in the box; the exhaust port 7 of the box 1 is connected to the exhaust gas treatment device through a second pipeline; the first pipeline and the second pipeline are both provided with a filter component; the first through hole 3 is connected to the vacuum system 10 through a third pipeline; the second through hole 4 is connected to the re-pressurization system 11 through a fourth pipeline;

[0078] The fluorinated gas storage device is connected to the gas inlet 6 of the box through a first pipeline;

[0079] The hydraulic system 8 is used to compress the first sealing component on the reagent bottle; the first sealing component is placed at the opening of the reagent bottle; the first sealing component is a rubber plug;

[0080] The detection system includes two infrared detection devices 9, which are arranged on two side wall plates arranged opposite to each other in the accommodating chamber 2; the infrared detection device 9 is used to detect the concentration of fluorinated gas in the box; a supporting device is also arranged in the box 1; the supporting device is used to support the infrared detection device;

[0081] The vacuum system 10 is used to form a negative pressure state in the containing chamber;

[0082] The pressure restoring system 11 is used to restore the pressure in the containing chamber to normal pressure or slightly positive pressure;

[0083] The device system further comprises a plurality of second sealing components; the second sealing components are independently arranged at the door axes of the box body 1 and the accommodating chamber 2; the second sealing components comprise sealing rings;

[0084] The control system 12 (such as Figure 2 As shown) is used to control the start and stop of the vacuum system 10, the re-pressurization system 11 and the hydraulic system 8, and monitor the parameter changes in the infrared detection device 9.

[0085] In the following embodiments and comparative examples, the boxes are all negative pressure resistant boxes; the fluorinated gases are all octafluoropropane; there is no specific limitation on the number of reagent bottles, and the specific number is determined according to production requirements.

[0086] Example 1

[0087] This embodiment provides a device system for real-time detection of reagent preparation coupled with gas concentration (eg Figure 3 As shown), the device system includes a box 1, a fluorinated gas storage device, a vacuum system, a re-pressurization system 11, a hydraulic system 8, a detection system and a control system 12;

[0088] The box body 1 is composed of an upper cover plate, a lower bottom plate and four side wall plates; a first through hole 3 is provided on the upper cover plate; a second through hole 4 is provided on the lower bottom plate; a space formed between the upper cover plate and the lower bottom plate is a receiving cavity 2; an air inlet 6, a liquid discharge port 5 and an air outlet 7 are independently provided on the box body 1; avoidance grooves are provided at the first through hole 3, the second through hole 4 and the air inlet 6;

[0089] The box 1 is provided with a hydraulic system 8 and a detection system, and a plurality of reagent bottles are placed in the accommodating chamber 2 in the box 1; the exhaust port 7 of the box 1 is connected to the exhaust gas treatment device through a second pipeline; the first pipeline and the second pipeline are both provided with a filter component; the first through hole 3 is connected to the vacuum system through a third pipeline; the second through hole 4 is connected to the re-pressurization system 11 through a fourth pipeline;

[0090] The fluorinated gas storage device is connected to the gas inlet 6 of the box through a first pipeline;

[0091] The hydraulic system 8 is used to compress the first sealing component on the reagent bottle; the first sealing component is placed at the opening of the reagent bottle; the first sealing component is a rubber plug;

[0092] The detection system includes two infrared detection devices 9, which are arranged on two side wall plates arranged opposite to each other in the accommodating chamber 1; the infrared detection device 9 is used to detect the concentration of fluorinated gas in the box; a supporting device is also arranged in the box 1; the supporting device is used to support the infrared detection device;

[0093] The vacuum system is used to form a negative pressure state in the containing chamber; the vacuum system comprises a condensing device 13 and a vacuum device 14 connected in sequence;

[0094] The pressure restoring system 11 is used to restore the pressure in the containing chamber to normal pressure or slightly positive pressure;

[0095] The device system further comprises a plurality of second sealing components; the second sealing components are independently arranged at the door axes of the box body 1 and the accommodating chamber 2; the second sealing components comprise sealing rings;

[0096] The control system 12 is used to control the start and stop of the vacuum system, the re-pressurization system and the hydraulic system, and monitor parameter changes in the infrared detection device.

[0097] Example 2

[0098] This embodiment provides a device system for real-time detection of reagent preparation coupled with gas concentration, which further defines the following on the basis of Embodiment 1:

[0099] The hydraulic system comprises a hydraulic assembly and a first pressure regulating device connected in sequence; the re-pressurization system comprises an air charging device and a second pressure regulating device connected in sequence; the control system is a PLC control system;

[0100] The device system also includes an alarm system;

[0101] The PLC control system is connected with the vacuum system, the re-pressurization system, the hydraulic system, the detection system and the alarm system through control signals.

[0102] Example 3

[0103] This embodiment provides a device system for reagent preparation coupled with real-time detection of gas concentration. Except that no avoidance groove is provided at the first through hole, the second through hole and the air inlet, other conditions are the same as those of Embodiment 2.

[0104] Comparative Example 1

[0105] This comparative example provides a device system for reagent preparation coupled with real-time detection of gas concentration. Except that the detection system is only provided with one infrared detection device, other conditions are the same as those of Example 2.

[0106] Comparative Example 2

[0107] This comparative example provides a device system for real-time detection of reagent preparation coupled gas concentration. Except that the "infrared detection device" in the detection system is replaced by a "pressure sensing device", and the pressure sensing device is arranged on the top of the box and connected to the containing cavity, other conditions are the same as those in Example 2.

[0108] Comparative Example 3

[0109] This comparative example provides a device system for reagent preparation coupled with real-time detection of gas concentration, in which the fluorinated gas storage device is directly connected to the reagent bottle through a pipeline, and other structures are set with reference to Example 2.

[0110] Application Example 1

[0111] This application example provides a method for using reagent preparation coupled with real-time detection of gas concentration, which is performed using the device system provided in Example 1 and specifically includes:

[0112] (1) The containing chamber is evacuated to a negative pressure state by a vacuum system, and then the fluorinated gas in the fluorinated gas storage device is charged into the containing chamber, and the fluorinated gas concentration in the containing chamber is monitored in real time by an infrared detection device. When the gas concentration reaches a set value required for production, the charging of the fluorinated gas is stopped by controlling the control system;

[0113] (2) using a re-pressure system to restore the pressure in the containing chamber to normal pressure or slightly positive pressure, and at the same time using a hydraulic system to compress the first sealing component on the reagent bottle and using an infrared detection device to monitor the concentration of the fluorinated gas in the containing chamber in real time, and then taking out the reagent bottle;

[0114] The pressure recovery method comprises: extracting the fluorinated gas in the containing chamber by using a vacuum system, and then filling air into the containing chamber by using a pressure recovery system to replace the gas, and after the replacement is completed, detecting whether the concentration of the fluorinated gas in the containing chamber meets the standard by using an infrared detection device.

[0115] The device system and use method provided in this application example can automatically prepare the corresponding reagents and improve the purity of the reagents. It can also detect the concentration of octafluoropropane in the box in real time, confirm whether the octafluoropropane in the box has sufficient negative pressure resistance, avoid production interruptions or production accidents caused by excessive fluorinated gas concentration, and effectively control the emission of octafluoropropane during use.

[0116] Application Example 2

[0117] This application example provides a method for using reagent preparation coupled with real-time detection of gas concentration. Except for using the device system provided in Example 2, other conditions are the same as those in Application Example 1.

[0118] The device system and use method provided in this application example can automatically prepare the corresponding reagents and improve the purity of the reagents. It can also detect the concentration of octafluoropropane in the box in real time, confirm whether the octafluoropropane in the box has sufficient negative pressure resistance, avoid production interruptions or production accidents caused by excessive fluorinated gas concentration, and effectively control the emission of octafluoropropane during use.

[0119] Application Example 3

[0120] This application example provides a method for using reagent preparation coupled with real-time detection of gas concentration. Except for using the device system provided in Example 3, other conditions are the same as those in Application Example 1.

[0121] Although the device system and use method provided in this application example can detect the concentration of octafluoropropane in the box in real time, there is a risk of reagent bottles tipping over during the reagent preparation process, thereby affecting production efficiency.

[0122] Comparative application example 1

[0123] This comparative application example provides a method for using reagent preparation coupled with real-time detection of gas concentration. Except for using the device system provided in comparative example 1, other conditions are the same as those in application example 1.

[0124] Although the device system and use method provided in this comparative application example can detect the concentration of octafluoropropane in the box in real time, only one infrared detection device is provided, which cannot well indicate whether the overall concentration in the box has reached the required requirement of the reagent, making the reliability of the octafluoropropane concentration detection result low, resulting in the inability to produce qualified products.

[0125] Comparative Application Example 2

[0126] This comparative application example provides a method for using reagent preparation coupled with real-time detection of gas concentration. Except for using the device system provided in comparative example 2, other conditions are the same as those in application example 1.

[0127] The device system and use method provided in this comparative application example, although the pressure sensor device can indirectly calculate the concentration of octafluoropropane in the box, it cannot directly reflect the negative pressure resistance of octafluoropropane gas in the box. In addition, the pressure sensor device is affected by environmental factors during the detection process, and there are large errors, resulting in low accuracy and reliability of the detection results, which in turn leads to the inability to produce qualified products.

[0128] Comparative Application Example 3

[0129] This comparative application example provides a method for using reagent preparation coupled with real-time detection of gas concentration. Except for using the device system provided in comparative example 3, other conditions are the same as those in application example 1.

[0130] The device system and use method provided in this comparative application example have thousands of reagent bottles in the accommodating chamber. If the fluorinated gas storage device is directly connected to the reagent bottles through pipelines, not only will the pipelines in the accommodating chamber be cumbersome, but the reagent bottles in a semi-plugged state cannot be completely plugged, resulting in the product being unsealed and even possibly causing the reagent bottles to rupture.

[0131] The applicant declares that the above is only a specific implementation mode of the present invention, but the protection scope of the present invention is not limited thereto. Those skilled in the art should understand that any changes or substitutions that can be easily thought of by those skilled in the art within the technical scope disclosed by the present invention shall fall within the protection scope and disclosure scope of the present invention.

Claims

1. A device system for real-time detection of reagent preparation coupled with gas concentration, characterized in that: The device system includes a box, a fluorinated gas storage device, a vacuum system, a re-pressurization system, a hydraulic system, a detection system and a control system; The box is provided with a hydraulic system and a detection system. A plurality of open containers are placed in the accommodating cavity in the box body; The hydraulic system is used to compress the first sealing component on the open container; The detection system comprises at least two infrared detection devices, and the infrared detection devices are arranged in the accommodating cavity; The infrared detection device is used to detect the concentration of fluorinated gas in the box; The fluorinated gas storage device is connected to the air inlet of the box through a first pipeline; The vacuum system is used to form a negative pressure state in the containing chamber; The pressure restoring system is used to restore the pressure in the containing chamber to normal pressure or slightly positive pressure; The control system is used to control the start and stop of the vacuum system, the re-pressurization system and the hydraulic system, and monitor parameter changes in the infrared detection device.

2. The device system according to claim 1, characterized in that: The box is a negative pressure resistant box; Preferably, the box body is composed of an upper cover plate, a lower bottom plate and four side wall plates; Preferably, a first through hole is provided on the upper cover plate; Preferably, a second through hole is provided on the lower bottom plate; Preferably, the space formed between the upper cover plate and the lower base plate is a receiving cavity; Preferably, the box body is independently provided with an air inlet, a liquid discharge port and an air outlet; Preferably, the first through hole, the second through hole and the air inlet are all provided with avoidance grooves; Preferably, the open container comprises a reagent bottle; Preferably, the first sealing component comprises a rubber plug.

3. The device system according to claim 2, characterized in that: The exhaust port of the box is connected to the exhaust gas treatment device through a second pipeline; Preferably, both the first pipeline and the second pipeline are provided with a filter component; Preferably, the first through hole is connected to the vacuum system via a third pipeline; Preferably, the second through hole is connected to the pressure-recovering system via a fourth pipeline.

4. The device system according to any one of claims 1 to 3, characterized in that: The hydraulic system comprises a hydraulic assembly and a first pressure regulating device connected in sequence; Preferably, the detection system comprises 2 infrared detection devices; Preferably, the infrared detection device is arranged on two side wall plates arranged opposite to each other in the accommodating cavity; Preferably, a supporting device is also provided in the box; Preferably, the supporting device is used to support the infrared detection device.

5. The device system according to any one of claims 1 to 4, characterized in that: The vacuum system comprises a vacuum device; Preferably, the re-pressurization system comprises an inflation device and a second pressure regulating device which are connected in sequence.

6. The device system according to any one of claims 1 to 5, characterized in that: The control system includes a PLC control system; Preferably, the PLC control system is connected to the vacuum system, the re-pressurization system, the hydraulic system and the detection system through control signals.

7. The device system according to any one of claims 1 to 6, characterized in that: The device system also includes a plurality of second sealing components and an alarm system; Preferably, the second sealing component is independently arranged at the door shafts of the box body and the accommodating chamber; Preferably, the second sealing component comprises a sealing ring; Preferably, the PLC control system is connected to the alarm system via a control signal.

8. A method for using reagent preparation coupled with real-time detection of gas concentration, characterized in that: The method of use is carried out using the device system according to any one of claims 1 to 7, comprising: (1) The containing chamber is evacuated to a negative pressure state by a vacuum system, and then the fluorinated gas in the fluorinated gas storage device is charged into the containing chamber, and the fluorinated gas concentration in the containing chamber is monitored in real time by an infrared detection device. When the gas concentration reaches a set value required for production, the charging of the fluorinated gas is stopped by controlling the control system; (2) The pressure in the containing chamber is restored to normal pressure or slightly positive pressure by using a re-pressurization system, and at the same time, the first sealing component on the open container is compressed by a hydraulic system and the concentration of the fluorinated gas in the containing chamber is monitored in real time by an infrared detection device, and then the open container is taken out.

9. The method of use according to claim 8, characterized in that: The fluorinated gas includes octafluoropropane.

10. The method of use according to claim 8 or 9, characterized in that: The pressure recovery method in step (2) comprises: extracting the fluorinated gas in the containing chamber by using a vacuum system, and then filling the containing chamber with air by using a re-pressurization system to replace the gas. After the replacement is completed, an infrared detection device is used to detect whether the concentration of the fluorinated gas in the containing chamber meets the standard.

Images