Mineral nutrient composition for promoting physique growth of infants and application of mineral nutrient composition

Abstract

The invention discloses a mineral nutrient composition for promoting physique growth of infants and application of the mineral nutrient composition. The invention provides a nutritional composition, the nutritional composition comprises mineral nutrients, and the mineral nutrients comprise iron, magnesium, zinc and selenium; wherein in the mineral nutrients, the mass ratio of iron to magnesium to zinc to selenium is (1.2 to 3.2) to (12 to 30) to 1 to (0.006 to 0.015). The composition formed by matching mineral nutrients or combining the mineral nutrients with other components has a synergistic effect, the effect of promoting physique growth of the infants is facilitated, and food containing the nutritional composition can also promote physique development and intelligence development of the infants.

Description

Technical Field

[0001] The invention relates to a nutritional composition, belonging to the field of food nutritional compositions, and in particular to a nutritional composition and application thereof in infant formula food. Background Art

[0002] The period of infants (including newborns) and older infants refers to the period from birth to one year old. During this period, the weight and height of infants increase most rapidly, especially in the first three months after birth. The first year is the first growth peak after birth. The growth rate gradually slows down after the second year until the second growth peak occurs in adolescence. Weight is one of the most important indicators for evaluating infant growth. Weight is greatly affected by environmental factors, such as nutrition, complementary food addition, disease and other factors. It is often used as an indicator for growth detection and reflects the nutritional status of infants, especially the recent nutritional status. Weight increases fastest in the first three months, generally 600-1000g per month, and an average increase of about 600-800g per month from 3 to 6 months. Height mainly reflects long-term nutritional status and is more obviously affected by genetics, race and environment. Head circumference is an important indicator reflecting skull growth and brain development. In addition, the World Health Organization (WHO) also recommends the use of weight for age z score (WAZ), length for age z score (LAZ) and weight-for-headcircumference z score (HCZ) to evaluate infant growth. Good growth and development during infancy is the foundation of lifelong health, and adequate nutritional support is particularly important for promoting physical and intellectual development during this period.

[0003] Minerals are essential nutrients for the human body and play a vital role in the growth and development of infants and young children (reference 1). It is well known that zinc deficiency can lead to growth retardation. However, a recent systematic review showed that the association between the mineral content of infants and young children and their growth and development was not consistent (reference 2). This review included 13 research articles investigating the results of the relationship between the zinc content in breast milk and infant weight. Among them, 5 articles reported the infant's WAZ index, 2 results showed a positive correlation, and 3 did not find a correlation between the two. The results of a study on zinc and infant height showed that zinc intake may be important for height-related outcomes in the second half of the infant's life. Several other studies found that zinc intake or concentration was not associated with height-related outcomes in the first few months after birth (references 3-7). The reason for this may be that there are complex interactions between the mineral components consumed, resulting in differences in research results. High-quality research using chronobiology and systems biology methods is needed to understand how various mineral nutrients affect infant growth independently and together.

[0004] A study using principal component analysis to investigate the mineral composition patterns of lactating Guatemalan women and to examine the relationship between mineral patterns and infant anthropometric measures showed that higher mineral element concentration patterns of Cu, K, Na, Se, and Zn in breast milk were negatively correlated with WAZ and LAZ of infants in the early lactation period (18-46 days) (reference 8).

[0005] It is well documented that most minerals (e.g. Mg and Zn) are bound to citrate, which is easily released as ions and thus may be involved in overall metabolism (Cit. 9, 10).

[0006] Reference 11 discloses that three nutrients including galacto-oligosaccharides, human milk oligosaccharides and lactoferrin can synergistically enhance the body's calcium utilization rate and effectively promote physical development. It can also be industrialized and suitable for infants, especially those with special medical conditions. However, no patents related to mineral ratio combinations for promoting physical development have been found.

[0007] Citations

[0008] Cited literature 1: He BZ, Sun XJ, Quan MY, Wang DH. Macronutrients and energy in milk from mothers of premature infants. Zhongguo Dang Dai Er Ke Za Zhi. (2014) 16:679-83.

[0009] Citation 2: Reyes SM, Brockway MM, McDermid JM, Chan D, Granger M, Refvik R, et al. Human milk micronutrients and child growth and body composition in the first 2y: A systematic review. Adv Nutr (2023) S2161-8313:01326-1.

[0010] Citation 3: Mahdavi R, Nikniaz L, Gayemmagami SJ. Association between zinc, copper, and iron concentrations in breast milk and growth of healthy infants in Tabriz, Iran. Biol Trace Elem Res. 2010;135(1-3):174-181.

[0011] Citation 4: L, Perheentupa J, V, Siimes MA. Low zinc intake during exclusive breast-feeding does not impair growth. J Pediatr Gastroenterol Nutr. 1994;18(3):361-370.

[0012] Citation 5: Samuel TM, Thomas T, Thankachan P, Bhat S, Virtanen SM, Kurpad AV. Breast milk zinc transfer and early post-natal growth among urban South Indian term infants using measures of breast milk volume and breast milk zinc concentrations. Matern Child Nutr. 2014;10(3):398-409.

[0013] Citation 6: A.S. Cisse, N. Dossou, M. Ndiaye, A.L. Gueye, D.B. Diop, B. Diaham, et al., Stable isotope aided evaluation of community nutrition program: effect of food supplementation schemes on maternal and infant nutritional status, Food Nutr. Bull. 23(3) (2002) 169 - 173.

[0014] Citation 7: C. Li, N.W. Solomons, M.E. Scott, K.G. Koski, Anthropometry before day 46 and growth velocity before 6 months of Guatemalan breastfed infants are associated with subclinical mastitis and milk cytokines, minerals, and trace elements, J. Nutr. 149(9) (2019) 1651 - 1659.

[0015] Citation 8: Li C, Solomons NW, Scott ME, Koski KG. Minerals and trace elements in human breast milk are associated with guatemalan infant anthropometric outcomes within the first 6 months. J Nutr. (2016) 146:2067 - 74.

[0016] Citation 9: B, Stanislowski AG, Hurley LS. Isolation of a low molecular weight zinc binding ligand from human milk. J Inorg Biochem. (1980) 12:71 - 8.

[0017] Citation 10: B, Yuen M, Glazier C, Litov RE. Magnesium bioavailability from human milk, cow milk, and infant formula in suckling ratpups. Am J Clin Nutr. (1993) 58:392-7.

[0018] Reference 11: CN115644458A Summary of the invention

[0019] Problem that the invention aims to solve

[0020] The exploration of mineral nutrients on infant growth and development in the above-cited documents 1-11 is mostly still limited to the effects of individual components, and no attempt has been made to explore the synergistic effects of several mineral combinations on infant growth and development.

[0021] Therefore, the present invention provides a mineral nutritional composition for promoting the physical growth of infants and its use. The nutritional composition is prepared by combining four mineral nutrients, namely iron, magnesium, zinc and selenium, in a specific ratio, which can synergistically promote the physical growth of infants.

[0022] Solutions for solving problems

[0023] In some aspects of the present invention, a nutritional composition is provided, wherein the nutritional composition comprises mineral nutrients, wherein the mineral nutrients comprise iron, magnesium, zinc, and selenium;

[0024] Among them, in the mineral nutrients, the mass ratio of iron, magnesium, zinc and selenium is (1.2-3.2): (12-30): 1: (0.006-0.015).

[0025] In some embodiments, in the mineral nutrients, the mass ratio of iron, magnesium, zinc and selenium is (2-3): (20-27): 1: (0.007-0.013).

[0026] In some embodiments, the mineral nutrients also include copper, manganese, calcium, phosphorus, sodium, potassium, chloride, and iodine.

[0027] In some embodiments, the nutritional composition further includes functional ingredients and active proteins.

[0028] In some embodiments, the functional ingredients include at least one of inositol, taurine, L-carnitine, docosahexaenoic acid (DHA), eicosatetraenoic acid (ARA), galacto-oligosaccharides, 1,3-dioleyl-2-palmityl triglyceride, lutein, other functional minerals and nucleotides.

[0029] In some embodiments, the active protein comprises at least one of lactoferrin and casein phosphopeptide.

[0030] In some embodiments, the nutritional composition further comprises carbohydrates.

[0031] In some preferred embodiments, the carbohydrate comprises lactose.

[0032] In some embodiments, the nutritional composition further comprises one or more of multivitamins, protein and fat.

[0033] In some aspects of the present invention, there is provided a use of a nutritional composition in preparing a food for promoting growth and development.

[0034] In some embodiments, the promoting growth and development comprises promoting the growth and development of infants and young children; the promoting growth and development comprises promoting the increase in height.

[0035] Effects of the Invention

[0036] After a lot of further research, the present invention found that the four mineral nutrients of iron, magnesium, zinc and selenium combined in a specific ratio can synergistically promote the physical development of infants.

[0037] The object of the present invention is to provide a safe and effective nutritional composition and its use, which combines the mineral nutrients iron, magnesium, zinc and selenium in an appropriate ratio to play a synergistic role in promoting the physical growth of infants. DETAILED DESCRIPTION

[0038] Various exemplary embodiments, features and aspects of the present invention will be described in detail below. The word "exemplary" used here means "used as an example, embodiment or illustrative". Any embodiment described here as "exemplary" is not necessarily interpreted as being superior or better than other embodiments.

[0039] In addition, in order to better illustrate the present invention, numerous specific details are provided in the following specific embodiments. It should be understood by those skilled in the art that the present invention can be implemented without certain specific details. In other examples, methods, means, equipment and steps well known to those skilled in the art are not described in detail in order to highlight the subject matter of the present invention.

[0040] Unless otherwise stated, the units used in this specification are all international standard units, and the numerical values ​​and numerical ranges appearing in the present invention should be understood to include the inevitable systematic errors in industrial production.

[0041] In this specification, the word "may" means both performing a certain process and not performing a certain process.

[0042] In this specification, the references to "some specific / preferred embodiments", "other specific / preferred embodiments", "embodiments", etc., mean that the specific elements (e.g., features, structures, properties and / or characteristics) described in connection with the embodiments are included in at least one embodiment described herein, and may or may not exist in other embodiments. In addition, it should be understood that the elements may be combined in various embodiments in any suitable manner.

[0043] In this specification, the numerical range expressed using "a numerical value A to a numerical value B" means a range including the endpoints numerical values ​​A and B.

[0044] In the present invention, the term "about" or "substantially" or "essentially" may mean that a value includes the standard deviation of the error of the device or method used to determine the value. The numerical ranges and parameters used to define the present invention are all approximate values, and the relevant numerical values ​​in the specific embodiments have been presented as accurately as possible. However, any numerical value essentially inevitably contains the standard deviation caused by the aforementioned testing device or method. Therefore, unless otherwise explicitly stated, it should be understood that all ranges, quantities, numerical values ​​and percentages used in the present invention are modified by "about". Here, "about" generally means that the standard deviation of the actual value and the theoretical model or theoretical data is within 2%, preferably 1%, and more preferably 0.5%.

[0045] In the present invention, "infant" is used to refer to a human group of 0 to 6 months old.

[0046] In the present invention, "older infants" are used to refer to a human group of 6 to 12 months of age.

[0047] In the present invention, the term "infant" is used to refer to a human group of 12 to 36 months old.

[0048] In the present invention, "infants" are used to refer to a human group under 3 years old.

[0049] In the present invention, the terms "comprising", "having", "including" or "containing" may refer to being inclusive or open-ended, and do not exclude additional, uncited components or method steps. At the same time, "comprising", "having", "including" or "containing" may also refer to being closed, excluding additional, uncited components or method steps.

[0050] (Nutritional composition)

[0051] The present invention provides a nutritional composition, wherein the nutritional composition comprises mineral nutrients, and the mineral nutrients comprise iron, magnesium, zinc and selenium.

[0052] In some embodiments, in the mineral nutrients, the mass ratio of iron, magnesium, zinc and selenium is (1.2-3.2): (12-30): 1: (0.006-0.015).

[0053] The present invention creatively discovers that the mineral nutrients iron, magnesium, zinc and selenium are combined in appropriate proportions to achieve a synergistic effect in promoting the physical growth of infants and young children.

[0054] Mineral nutrients

[0055] From the perspective of further promoting the development of infants and young children, in some preferred embodiments, the mass ratio of iron, magnesium, zinc, and selenium in the mineral nutrients of the nutritional composition is (1.5-3.0): (15-28): 1: (0.006-0.014). In some more preferred embodiments, the mass ratio of iron, magnesium, zinc, and selenium in the mineral nutrients of the nutritional composition is (2-3): (20-27): 1: (0.007-0.013), for example, the mass ratio of iron, magnesium, zinc, and selenium is 2:20: 0.007: 1; the mass ratio of iron, magnesium, zinc, and selenium is 3:27: 1: 0.013; the mass ratio of iron, magnesium, zinc, and selenium is 2:26: 0.008: 1.

[0056] In some embodiments, based on the mass of the nutritional composition of 100 g, the mineral nutrients in the nutritional composition include: iron (5.5-10 mg / 100 g), magnesium (61-82 mg / 100 g), selenium (15.5-40 μg / 100 g), and zinc (1-5 mg / 100 g).

[0057] In some preferred embodiments, based on the mass of the nutritional composition of 100 g, the mineral nutrients in the nutritional composition include: iron (6-9 mg / 100 g), magnesium (61-78 mg / 100 g), selenium (20-38 μg / 100 g), and zinc (2-5 mg / 100 g).

[0058] In some more preferred embodiments, based on the mass of the nutritional composition of 100g, the mineral nutrients in the nutritional composition include: iron (6-8mg / 100g), magnesium (61-75mg / 100g), selenium (22-35μg / 100g), and zinc (2.5-5mg / 100g), for example: iron (6.3mg / 100g), magnesium (63.4mg / 100g), selenium (22.2μg / 100g), and zinc (3.2mg / 100g); iron (7.6mg / 100g), magnesium (68.5mg / 100g), selenium (33μg / 100g), and zinc (2.53mg / 100g); iron (5.7mg / 100g), magnesium (74.2mg / 100g), selenium (22.8μg / 100g), and zinc (2.9mg / 100g).

[0059] For the mineral nutrients of the present invention, these mineral nutrients are provided by compounds containing corresponding elements. In some preferred embodiments, the mineral nutrients include: sodium citrate, potassium chloride, copper sulfate, magnesium sulfate, ferric pyrophosphate, zinc sulfate, manganese sulfate, calcium citrate, calcium hydrogen phosphate, potassium iodate, sodium selenite.

[0060] It is understood that in addition to iron, magnesium, zinc, and selenium, mineral nutrients may also include other elements, such as copper, manganese, calcium, phosphorus, sodium, potassium, chlorine, iodine, etc. In some preferred embodiments, the minerals are calculated by the weight of the nutritional composition, and the other elements of the mineral nutrients in the nutritional composition include: sodium (165-185 mg / 100 g), potassium (375-400 mg / 100 g), copper (340-360 μg / 100 g), manganese (30-50 μg / 100 g), calcium (340-360 mg / 100 g), phosphorus (190-210 mg / 100 g) , iodine (100-110μg / 100g), chlorine (270-290mg / 100g), for example: sodium (175mg / 100g), potassium (385mg / 100g), copper (350μg / 100g), manganese (40μg / 100g), calcium (350mg / 100g), phosphorus (200mg / 100g), iodine (106.0μg / 100g), chlorine (280mg / 100g).

[0061] Functional ingredients and active proteins

[0062] In some embodiments, the nutritional composition further includes functional ingredients and active proteins.

[0063] In some specific embodiments, the functional ingredients include: inositol, taurine, L-carnitine, docosahexaenoic acid (DHA), eicosatetraenoic acid (ARA), galacto-oligosaccharides, 1,3-dioleyl-2-palmityl triglyceride, lutein, nucleotides, and at least one of other functional minerals.

[0064] In some optional embodiments, other functional mineral elements may be added to the nutritional composition, such as at least one of molybdenum, chromium, nickel, vanadium, silicon, tin, fluorine and the like.

[0065] The combination of mineral nutrients in the above-mentioned iron, magnesium, zinc and selenium ratios combined with the above-mentioned functional ingredients can further enhance the effect on the physical growth of infants and young children.

[0066] In some preferred embodiments, based on the mass of the nutritional composition of 100g, the functional ingredients in the nutritional composition include: inositol (38-42mg / 100g), taurine (35-40mg / 100g), L-carnitine (8-10mg / 100g), docosahexaenoic acid (DHA) (95-100mg / 100g), eicosatetraenoic acid (ARA) (163-165mg / 100g), galacto-oligosaccharide (2-5g / 100g), 1,3-dioleyl 2-palmitoyl triglyceride (5-8g / 100g), lutein (78-82μ g / 100g) and / or nucleotides (28-32mg / 100g), for example: inositol (40mg / 100g), taurine (38mg / 100g), L-carnitine (9.0mg / 100g), docosahexaenoic acid (DHA) (97.0mg / 100g), eicosatetraenoic acid (ARA) (164.9mg / 100g), galacto-oligosaccharides (3.0g / 100g), 1,3-dioleyl 2-palmityl triglyceride (6.0g / 100g), lutein (80μg / 100g) and / or nucleotides (30.0mg / 100g).

[0067] The present invention can further effectively promote the physical development of infants and young children and help them build a foundation for a healthy body through the combination of mineral nutrients in a proportion of iron, magnesium, zinc and selenium and the above-mentioned preferred functional component substances.

[0068] In some specific embodiments, the active protein comprises: at least one of lactoferrin and casein phosphopeptide.

[0069] The combination of mineral nutrients in the above-mentioned iron, magnesium, zinc and selenium ratio combined with the above-mentioned active proteins can help further improve the immunity and resistance of infants and young children.

[0070] In some preferred embodiments, based on the total mass of the nutritional composition of 100 g, the active protein components in the nutritional composition contain lactoferrin (43-47 mg / 100 g) and casein phosphopeptide (38-42 mg / 100 g), for example: lactoferrin (45.0 mg / 100 g) and casein phosphopeptide (40.0 mg / 100 g).

[0071] The combination of the mineral nutrients in the present invention and the above nutrients can further promote the normal development of infants and young children and enhance the body's ability to adapt to changes in the external environment. Therefore, the above nutritional composition provided by the present invention can help infants and young children build good immunity.

[0072] carbohydrate

[0073] In some embodiments, the nutritional composition further includes carbohydrates.

[0074] The carbohydrate component described in the present invention mainly refers to sugar substances. The sugar substances are usually the general name of polyhydroxy aldehydes or polyhydroxy ketones and their polycondensates and certain derivatives, which are generally composed of three elements: carbon, hydrogen and oxygen. The sugar substances can be written as the empirical molecular formula: C n (H 2 O) n .

[0075] In the present invention, the carbohydrate substances may typically include monosaccharides, disaccharides, polysaccharides or oligosaccharides.

[0076] In some preferred embodiments, the carbohydrate in the nutritional composition includes lactose.

[0077] Lactose is the main carbohydrate in breast milk and the preferred carbohydrate source for infants. In addition, lactose can regulate the body, provide appropriate and adequate nutritional support, and promote the body's absorption of mineral nutrients or other nutrients.

[0078] In some preferred embodiments, based on the total mass of the nutritional composition of 100 g, the nutritional composition contains 52-57 g / 100 g of carbohydrates, more preferably 53.5-55.5 g / 100 g, for example 54.2 g / 100 g.

[0079] Protein and fat

[0080] In some embodiments, the nutritional composition further includes protein, and / or fat.

[0081] In some embodiments, the protein of the present invention is selected from at least one of whey protein powder, soy protein isolate, whole milk powder, whole egg powder, lactoferrin, bovine colostrum, amino acids, and protein peptides; and the amino acids are selected from at least one of L-lysine, L-glutamic acid, L-glutamic acid, L-arginine, L-tryptophan, L-glutamine, taurine, L-valine, L-isoleucine, and L-leucine; the protein peptides are selected from one or more of soybean oligopeptides, wheat protein peptides, silkworm pupa protein peptides, marine fish oligopeptide powder, kola peptides, amino peptides, and ovalbumin peptides.

[0082] In order to provide comprehensive nutrition, the fat structure in the nutritional composition is more reasonable to meet the growth and development nutritional needs of infants and young children, and the present invention uses a variety of edible oils to supply fat components. The fat may include at least one of saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, OPO structured lipids, EPA, and phospholipids. More specifically, the fat includes one or more of 1,3-dioleyl 2-palmitoyl triglyceride, sunflower oil, coconut oil, and linseed oil. In some preferred embodiments, based on the total mass of the nutritional composition of 100g, the nutritional composition contains 8 to 12g / 100g of protein and 26 to 28g / 100g of fat, such as 10g / 100g of protein and 27g / 100g of fat.

[0083] The combination of the mineral nutrients provided by the present invention with the above-mentioned protein and fat plays an important role in the growth and development, health maintenance, etc. of infants and young children. The protein contains various essential amino acids required by the human body in a reasonable ratio and is easily absorbed and utilized by the human body. Fat plays an important role in brain development, cardiovascular health, etc.

[0084] Therefore, the protein and / or fat in the composition of the present invention plays an irreplaceable role in the nutritional supplementation and growth and development of infants and young children.

[0085] Multivitamins

[0086] In some embodiments, the nutritional composition further comprises a multivitamin.

[0087] The vitamins in the present invention include choline components and other vitamin ingredients. For the convenience of expression, the other vitamin ingredients are also referred to as complex vitamins below.

[0088] In principle, there is no special requirement for the choline component of the present invention, and it can be used in accordance with the provisions of relevant laws and regulations. Typically, the choline component of the present invention can be choline chloride.

[0089] In this specification, "α-TE" means α-tocopherol equivalent, which is a unit for indicating vitamins.

[0090] In this specification, "RE" means retinol equivalent, which is a unit for indicating vitamins.

[0091] In some specific embodiments, the vitamin complex in the nutritional composition comprises vitamin A, vitamin D, vitamin E, vitamin K 1 , Vitamin B 1 , Vitamin B 2 , Vitamin B 6 , Vitamin B 12 , at least one of niacin, folic acid, pantothenic acid, vitamin C, biotin, and choline.

[0092] The composition formed by the above-mentioned complex vitamins and the matched mineral nutrients is beneficial to promoting the growth and development of infants and young children, and promoting the physical development and intellectual development during this period.

[0093] In some preferred embodiments, based on the total mass of the nutritional composition of 100g, the multivitamin in the nutritional composition comprises: vitamin A (355-365μg RE / 100g), vitamin D (11-15μg / 100g), vitamin E (4-8mg α-TE / 100g), vitamin K 1 (58~62μg / 100g), vitamin B 1 (645, 0-660 μg / 100g), vitamin B 2 (490~510μg / 100g), Vitamin B 6 (390~410μg / 100g), Vitamin B 12 (1-2μg / 100g), niacin (4000-4200μg / 100g), folic acid (65-69μg / 100g), pantothenic acid (3020-3080μg / 100g), vitamin C (65-75mg / 100g), biotin (15-17μg / 100g), choline (210-220mg / 100g), for example: vitamin A (360μgRE / 100g), vitamin D (13.0μg / 100g), vitamin E (6.00mgα-TE / 100g), vitamin K 1 (60.0μg / 100g), vitamin B 1 (650μg / 100g), Vitamin B 2 (500μg / 100g), Vitamin B 6 (400μg / 100g), Vitamin B 12(1.5μg / 100g), niacin (4100μg / 100g), folic acid (67μg / 100g), pantothenic acid (3050μg / 100g), vitamin C (70.0mg / 100g), biotin (16.0μg / 100g), choline (215.0mg / 100g).

[0094] The composition formed by the mineral nutrients in the proportion of the present invention and the above-mentioned other nutrients can effectively promote the physical development of infants and young children.

[0095] The present invention does not specifically limit the form of the composition, which can typically be liquid or solid, etc. In addition to the above components, other additives that can be used in the composition of the present invention are not specifically limited in principle, and can include additional active peptide components, other inorganic salts, probiotics and other components.

[0096] (use)

[0097] One object of the present invention is to use the nutritional composition in preparing food for promoting growth and development. Specifically, the promotion of growth and development includes promoting the growth and development of infants and young children. Further, the promotion of growth and development includes promoting the growth of height.

[0098] The present invention combines the mineral nutrients iron, magnesium, zinc and selenium in appropriate proportions to achieve a synergistic effect in promoting the growth and development (such as physical growth) of infants.

[0099] The nutritional composition of the present invention can be used to prepare a variety of foods, including infant formula foods, etc. In some specific embodiments, the infant formula foods include infant formula milk powder, and are particularly suitable for promoting the growth and development (eg, physical growth) of infants.

[0100] The infant formula food of the present invention includes infant formula food such as milk powder, liquid milk and breast milk substitute.

[0101] In the present invention, the "infant formula" includes infant formula, follow-up infant formula and toddler formula. Generally, infant formula is used as a breast milk substitute from birth, follow-up infant formula is used as a breast milk substitute from 6 to 12 months after the birth of the infant, and toddler formula refers to a breast milk substitute from 12 to 36 months after the birth of the infant.

[0102] In some preferred embodiments of the present invention, the food comprises an infant formula, for example, a "milk-based infant formula".

[0103] In the present invention, the "infant formula food" refers to a formula food suitable for normal infants, whose energy and nutritional components can meet the normal nutritional needs of infants aged 0 to 6 months.

[0104] In the present invention, the "milk-based infant formula food" refers to a product that uses milk and milk protein products as the main protein source, adds appropriate amounts of complex vitamins, mineral nutrients and (or) other raw materials, and is produced and processed only by physical methods.

[0105] In some embodiments, the growth and development is the growth of the infant in a population of the same age as assessed by weight-for-age z-score, height-for-age z-score and / or head circumference-for-age z-score.

[0106] The composition formed by combining the mineral nutrients in the proportions with other ingredients of the present invention is synergistic, which helps to promote the physical growth of infants and young children. Furthermore, the food containing such a nutritional composition can promote the physical development and intellectual development of infants and young children. Moreover, the mineral nutrients in the proportions described above can be combined with other ingredients in the nutritional composition to further improve the effect of promoting physical development and intellectual development.

[0107] It should be noted that the specific amount of each raw material in the infant formula containing the nutritional composition of the present invention should be adjusted and determined on the premise of meeting the requirements of the formula product index. The product performance indicators of the nutritional composition of the present invention in infant formula that are not described or listed in detail should be implemented in accordance with the provisions of "GB 10765-2021 Infant Formula" and "GB 10767-2021 Toddler Formula" and relevant standards and regulations.

[0108] Example

[0109] The embodiments of the present invention will be described in detail below in conjunction with the examples, but those skilled in the art will appreciate that the following examples are only used to illustrate the present invention and should not be considered to limit the scope of the present invention. If no specific conditions are specified in the examples, they are carried out according to normal conditions or the conditions recommended by the manufacturer. If the manufacturer is not specified for the reagents or instruments used, they are all conventional products that can be obtained commercially.

[0110] Embodiment 1:

[0111] The formula milk powder contains 2114 kJ / 100g of energy, 10g / 100g of protein, 27g / 100g of fat, and 54.2g / 100g of carbohydrates, all of which come from lactose. Vitamins include vitamin A (360μg RE / 100g), vitamin D (13.0μg / 100g), vitamin E (6.00mgα-TE / 100g), and vitamin K 1(60.0μg / 100g), vitamin B 1 (650μg / 100g), Vitamin B 2 (500μg / 100g), Vitamin B 6 (400μg / 100g), Vitamin B 12 (1.5μg / 100g), niacin (4100μg / 100g), folic acid (67μg / 100g), pantothenic acid (3050μg / 100g), vitamin C (70.0mg / 100g), biotin (16.0μg / 100g), choline (215.0mg / 100g). The minerals include sodium (175 mg / 100 g), potassium (385 mg / 100 g), copper (350 μg / 100 g), manganese (40 μg / 100 g), calcium (350 mg / 100 g), phosphorus (200 mg / 100 g), iodine (106.0 μg / 100 g), chlorine (280 mg / 100 g), iron (6.3 mg / 100 g), magnesium (63.4 mg / 100 g), selenium (22.2 μg / 100 g), and zinc (3.2 mg / 100 g). In this embodiment, the ratio of the four mineral nutrients of iron, magnesium, selenium, and zinc is 2:20:0.007:1. In addition, other nutrients contained in the formula include inositol (40 mg / 100g), taurine (38 mg / 100g), L-carnitine (9.0 mg / 100g), docosahexaenoic acid (DHA) (97.0 mg / 100g), eicosatetraenoic acid (ARA) (164.9 mg / 100g), galacto-oligosaccharides (3.0 g / 100g), 1,3-dioleyl 2-palmityl triglyceride (6.0 g / 100g), lutein (80 μg / 100g), nucleotides (30.0 mg / 100g), lactoferrin (45.0 mg / 100g), and casein phosphopeptide (40.0 mg / 100g).

[0112] Example 2

[0113] The formula milk powder contains 2114 kJ / 100g of energy, 10g / 100g of protein, 27g / 100g of fat, and 54.2g / 100g of carbohydrates, all of which come from lactose. Vitamins include vitamin A (360μg RE / 100g), vitamin D (13.0μg / 100g), vitamin E (6.00mgα-TE / 100g), and vitamin K 1 (60.0μg / 100g), vitamin B 1 (650μg / 100g), Vitamin B 2 (500μg / 100g), Vitamin B 6 (400μg / 100g), Vitamin B12 (1.5μg / 100g), niacin (4100μg / 100g), folic acid (67μg / 100g), pantothenic acid (3050μg / 100g), vitamin C (70.0mg / 100g), biotin (16.0μg / 100g), choline (215.0mg / 100g). The minerals include sodium (175 mg / 100 g), potassium (385 mg / 100 g), copper (350 μg / 100 g), manganese (40 μg / 100 g), calcium (350 mg / 100 g), phosphorus (200 mg / 100 g), iodine (106.0 μg / 100 g), chlorine (280 mg / 100 g), iron (7.6 mg / 100 g), magnesium (68.5 mg / 100 g), selenium (33 μg / 100 g), and zinc (2.53 mg / 100 g). In this embodiment, the ratio of the four mineral nutrients of iron, magnesium, selenium, and zinc is 3:27:0.013:1. In addition, other nutrients contained in the formula include inositol (40 mg / 100g), taurine (38 mg / 100g), L-carnitine (9.0 mg / 100g), docosahexaenoic acid (DHA) (97.0 mg / 100g), eicosatetraenoic acid (ARA) (164.9 mg / 100g), galacto-oligosaccharides (3.0 g / 100g), 1,3-dioleyl 2-palmityl triglyceride (6.0 g / 100g), lutein (80 μg / 100g), nucleotides (30.0 mg / 100g), lactoferrin (45.0 mg / 100g), and casein phosphopeptide (40.0 mg / 100g).

[0114] Example 3

[0115] The formula milk powder contains 2114 kJ / 100g of energy, 10g / 100g of protein, 27g / 100g of fat, and 54.2g / 100g of carbohydrates, all of which come from lactose. Vitamins include vitamin A (360μg RE / 100g), vitamin D (13.0μg / 100g), vitamin E (6.00mgα-TE / 100g), and vitamin K 1 (60.0μg / 100g), vitamin B 1 (650μg / 100g), Vitamin B 2 (500μg / 100g), Vitamin B 6 (400μg / 100g), Vitamin B 12(1.5μg / 100g), niacin (4100μg / 100g), folic acid (67μg / 100g), pantothenic acid (3050μg / 100g), vitamin C (70.0mg / 100g), biotin (16.0μg / 100g), choline (215.0mg / 100g). The minerals include sodium (175 mg / 100 g), potassium (385 mg / 100 g), copper (350 μg / 100 g), manganese (40 μg / 100 g), calcium (350 mg / 100 g), phosphorus (200 mg / 100 g), iodine (106.0 μg / 100 g), chlorine (280 mg / 100 g), iron (5.7 mg / 100 g), magnesium (74.2 mg / 100 g), selenium (22.8 μg / 100 g), and zinc (2.9 mg / 100 g). In this embodiment, the ratio of the four mineral nutrients of iron, magnesium, selenium, and zinc is 2:26:0.008:1. In addition, other nutrients contained in the formula include inositol (40 mg / 100g), taurine (38 mg / 100g), L-carnitine (9.0 mg / 100g), docosahexaenoic acid (DHA) (97.0 mg / 100g), eicosatetraenoic acid (ARA) (164.9 mg / 100g), galacto-oligosaccharides (3.0 g / 100g), 1,3-dioleyl 2-palmityl triglyceride (6.0 g / 100g), lutein (80 μg / 100g), nucleotides (30.0 mg / 100g), lactoferrin (45.0 mg / 100g), and casein phosphopeptide (40.0 mg / 100g).

[0116] Comparative Example 1

[0117] The formula milk powder contains 2114 kJ / 100g of energy, 10g / 100g of protein, 27g / 100g of fat, and 54.2g / 100g of carbohydrates, all of which come from lactose. Vitamins include vitamin A (360μg RE / 100g), vitamin D (13.0μg / 100g), vitamin E (6.00mgα-TE / 100g), and vitamin K 1 (60.0μg / 100g), vitamin B 1 (650μg / 100g), Vitamin B 2 (500μg / 100g), Vitamin B 6 (400μg / 100g), Vitamin B 12(1.5μg / 100g), niacin (4100μg / 100g), folic acid (67μg / 100g), pantothenic acid (3050μg / 100g), vitamin C (70.0mg / 100g), biotin (16.0μg / 100g), choline (215.0mg / 100g). The minerals include sodium (175 mg / 100 g), potassium (385 mg / 100 g), copper (350 μg / 100 g), manganese (40 μg / 100 g), calcium (350 mg / 100 g), phosphorus (200 mg / 100 g), iodine (106.0 μg / 100 g), chlorine (280 mg / 100 g), iron (7.6 mg / 100 g), magnesium (60.9 mg / 100 g), selenium (15.2 μg / 100 g), and zinc (7.6 mg / 100 g). In this embodiment, the ratio of the four mineral nutrients of iron, magnesium, selenium, and zinc is 1:8:0.002:1. In addition, other nutrients contained in the formula include inositol (40 mg / 100g), taurine (38 mg / 100g), L-carnitine (9.0 mg / 100g), docosahexaenoic acid (DHA) (97.0 mg / 100g), eicosatetraenoic acid (ARA) (164.9 mg / 100g), galacto-oligosaccharides (3.0 g / 100g), 1,3-dioleyl 2-palmityl triglyceride (6.0 g / 100g), lutein (80 μg / 100g), nucleotides (30.0 mg / 100g), lactoferrin (45.0 mg / 100g), and casein phosphopeptide (40.0 mg / 100g).

[0118] Comparative Example 2

[0119] The formula milk powder contains 2114 kJ / 100g of energy, 10g / 100g of protein, 27g / 100g of fat, and 54.2g / 100g of carbohydrates, all of which come from lactose. Vitamins include vitamin A (360μg RE / 100g), vitamin D (13.0μg / 100g), vitamin E (6.00mgα-TE / 100g), and vitamin K 1 (60.0μg / 100g), vitamin B 1 (650μg / 100g), Vitamin B 2 (500μg / 100g), Vitamin B 6 (400μg / 100g), Vitamin B 12(1.5μg / 100g), niacin (4100μg / 100g), folic acid (67μg / 100g), pantothenic acid (3050μg / 100g), vitamin C (70.0mg / 100g), biotin (16.0μg / 100g), choline (215.0mg / 100g). The minerals include sodium (175 mg / 100 g), potassium (385 mg / 100 g), copper (350 μg / 100 g), manganese (40 μg / 100 g), calcium (350 mg / 100 g), phosphorus (200 mg / 100 g), iodine (106.0 μg / 100 g), chlorine (280 mg / 100 g), iron (5.3 mg / 100 g), magnesium (42.3 mg / 100 g), selenium (26.4 μg / 100 g), and zinc (5.3 mg / 100 g). In this embodiment, the ratio of the four mineral nutrients of iron, magnesium, selenium, and zinc is 1:8:0.005:1. In addition, other nutrients contained in the formula include inositol (40 mg / 100g), taurine (38 mg / 100g), L-carnitine (9.0 mg / 100g), docosahexaenoic acid (DHA) (97.0 mg / 100g), eicosatetraenoic acid (ARA) (164.9 mg / 100g), galacto-oligosaccharides (3.0 g / 100g), 1,3-dioleyl 2-palmityl triglyceride (6.0 g / 100g), lutein (80 μg / 100g), nucleotides (30.0 mg / 100g), lactoferrin (45.0 mg / 100g), and casein phosphopeptide (40.0 mg / 100g).

[0120] Comparative Example 3

[0121] The formula milk powder contains 2114 kJ / 100g of energy, 10g / 100g of protein, 27g / 100g of fat, and 54.2g / 100g of carbohydrates, all of which come from lactose. Vitamins include vitamin A (360μg RE / 100g), vitamin D (13.0μg / 100g), vitamin E (6.00mgα-TE / 100g), and vitamin K 1 (60.0μg / 100g), vitamin B 1 (650μg / 100g), Vitamin B 2 (500μg / 100g), Vitamin B 6 (400μg / 100g), Vitamin B 12(1.5μg / 100g), niacin (4100μg / 100g), folic acid (67μg / 100g), pantothenic acid (3050μg / 100g), vitamin C (70.0mg / 100g), biotin (16.0μg / 100g), choline (215.0mg / 100g). The minerals include sodium (175 mg / 100 g), potassium (385 mg / 100 g), copper (350 μg / 100 g), manganese (40 μg / 100 g), calcium (350 mg / 100 g), phosphorus (200 mg / 100 g), iodine (106.0 μg / 100 g), chlorine (280 mg / 100 g), iron (7.6 mg / 100 g), magnesium (83.7 mg / 100 g), selenium (15.2 μg / 100 g), and zinc (7.6 mg / 100 g). In this embodiment, the ratio of the four mineral nutrients of iron, magnesium, selenium, and zinc is 1:11:0.002:1. In addition, other nutrients contained in the formula include inositol (40 mg / 100g), taurine (38 mg / 100g), L-carnitine (9.0 mg / 100g), docosahexaenoic acid (DHA) (97.0 mg / 100g), eicosatetraenoic acid (ARA) (164.9 mg / 100g), galacto-oligosaccharides (3.0 g / 100g), 1,3-dioleyl 2-palmityl triglyceride (6.0 g / 100g), lutein (80 μg / 100g), nucleotides (30.0 mg / 100g), lactoferrin (45.0 mg / 100g), and casein phosphopeptide (40.0 mg / 100g).

[0122] The mass ratios of iron, magnesium, zinc and selenium in various embodiments and comparative examples are summarized in Table 1.

[0123] Table 1: Mass ratio of four mineral nutrients: iron, magnesium, selenium and zinc in various embodiments and comparative examples

[0124] Experimental groups Corresponding examples or comparative examples The mass ratio of four mineral nutrients: iron, magnesium, selenium and zinc 1 Example 1 2：20：0.007：1 2 Example 2 3：27：0.013：1 3 Example 3 2：26：0.008：1 4 Comparative Example 1 1：8：0.002：1 5 Comparative Example 2 1：8：0.005：1 6 Comparative Example 3 1：11：0.002：1

[0125] Test Case

[0126] The present invention recruits 200 infants fed with pure formula milk powder of ≤1 month old, all of whom are healthy babies born at full term with normal physical development. The infants are divided into 6 groups in a random, double-blind method, and the number of people in each group and the corresponding embodiments or comparative examples of the feeding formula are shown in Table 2. The weight and height are measured after feeding for 6 months, and the weight-for-age z score (WAZ) is calculated using the WHO Anthro 3.2.2 evaluation software. The height-for-age z score (LAZ) and the head circumference z score (HCZ) for age are measured by the guardian using the special "intelligent baby scale" provided by the present invention. The maximum range of the intelligent baby scale is 50kg, the minimum range is 20g, and the accuracy is 5g. The height measurement range is 40cm-80cm, and the measurement accuracy is 0.1cm. The height and weight scores of the 3 groups of infants at 3 months, wherein the weight measurement is measured in the naked state, retaining 2 decimal points; the height is measured from the heel to the top of the head in the supine position. The anthropometric statistical results of the six groups of infants at 6 months are shown in the table below. Through analysis of variance, p < 0.05 indicates statistical difference.

[0127] The weight-for-age, height-for-age, and head circumference-for-age of the six groups of infants after intervention are shown in Table 2 .

[0128] Table 2: WAZ, LAZ, HCZ experimental results

[0129]

[0130] From the above analysis of variance statistical results, it can be seen that there is no significant difference in weight-for-age z-score (WAZ) and head circumference-for-age z-score (HCZ) of infants fed in the six experimental groups. However, there is a significant difference in length-for-age (LAZ) of infants fed in the six experimental groups (p=0.047). Therefore, it can be considered that the specific proportion of minerals in the present invention can increase physical development, while having no significant effect on other growth characteristics.

[0131] Further, it was also observed that the LAZ of the infants of Examples 1-3 was significantly higher than that of the control group. The growth of the infants of Examples 1-3 was better than that of the control group among the same age group. The ratio of the four minerals in Examples 1-3 ranged from 2 to 3: 20 to 27: 1: 0.007 to 0.013, which can more obviously obtain the technical effect of the present invention.

[0132] It should be noted that, although the technical solution of the present invention is introduced with specific examples, those skilled in the art will appreciate that the present invention should not be limited thereto.

[0133] The embodiments of the present invention have been described above, and the above description is exemplary, not exhaustive, and is not limited to the disclosed embodiments. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The selection of terms used herein is intended to best explain the principles of the embodiments, practical applications, or technical improvements in the market, or to enable other persons of ordinary skill in the art to understand the embodiments disclosed herein.

Claims

1. A nutritional composition, characterized in that The nutritional composition contains mineral nutrients, and the mineral nutrients contain iron, magnesium, zinc, and selenium; Among them, in the mineral nutrients, the mass ratio of iron, magnesium, zinc and selenium is (1.2-3.2): (12-30): 1: (0.006-0.015).

2. The nutritional composition according to claim 1, characterized in that In the mineral nutrients, the mass ratio of iron, magnesium, zinc and selenium is (2-3): (20-27): 1: (0.007-0.013).

3. The nutritional composition according to claim 1 or 2, characterized in that The nutritional composition also includes functional ingredients and active proteins.

4. The nutritional composition according to any one of claims 1 to 3, characterized in that The mineral nutrients also include copper, manganese, calcium, phosphorus, sodium, potassium, chlorine and iodine.

5. The nutritional composition according to claim 3, characterized in that The functional ingredients include: inositol, taurine, L-carnitine, docosahexaenoic acid (DHA), eicosatetraenoic acid (ARA), galacto-oligosaccharide, 1,3-dioleyl-2-palmityl triglyceride, lutein, at least one of other functional minerals and nucleotides.

6. The nutritional composition according to claim 3, characterized in that The active protein comprises: at least one of lactoferrin and casein phosphopeptide.

7. The nutritional composition according to any one of claims 1 to 6, characterized in that The nutritional composition further comprises carbohydrates, Preferably, the carbohydrate comprises lactose.

8. The nutritional composition according to any one of claims 1 to 7, characterized in that The nutritional composition further comprises one or more of complex vitamins, protein and fat.

9. Use of the nutritional composition according to any one of claims 1 to 8 in preparing food for promoting growth and development.

10. The use according to claim 9, characterized in that The promoting growth and development includes promoting the growth and development of infants and young children; the promoting growth and development includes promoting the increase in height.

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