Traditional Chinese medicine composition for treating chronic renal failure with anorexia as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention provides a traditional Chinese medicine composition for treating chronic renal failure with anorexia and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises the following raw material medicines in parts by mass: 24-36 parts of bighead atractylodes rhizome, 16-24 parts of raw astragalus membranaceus, 12-18 parts of poria cocos, 12-18 parts of fried endothelium corneum gigeriae galli, 8-12 parts of caulis perllae, 6-10 parts of ginseng, 4-6 parts of liquorice and 1-3 parts of coptis chinensis. The traditional Chinese medicine raw materials in the traditional Chinese medicine composition are matched with one another, so that the traditional Chinese medicine composition has a good treatment effect on anorexia symptoms accompanied by chronic renal failure, and can remarkably improve the condition of less eating, promote absorption and utilization of nutritional ingredients in food by organisms and improve the movement function of small intestines. The traditional Chinese medicine composition provided by the invention can improve the symptom of deficiency-cold in spleen and stomach of patients with chronic renal failure with anorexia, and has excellent clinical application prospects.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine compositions, and in particular to a Chinese medicine composition for treating chronic renal failure with poor appetite, and a preparation method and application thereof. Background Art

[0002] Chronic renal failure (CRF), also known as chronic renal insufficiency, is a disease caused by renal damage due to various chronic kidney diseases (such as primary glomerular disease, diabetic nephropathy, hypertensive renal damage, polycystic kidney disease, and immune disease renal damage), mainly manifested as renal dysfunction, retention of metabolites, etc. Chronic renal failure not only causes great damage to the patient's kidneys, but may also cause a variety of complications.

[0003] Poor appetite is a common digestive symptom in patients with chronic renal failure. In traditional Chinese medicine theory, poor appetite is usually related to spleen and stomach dysfunction, poor circulation of qi and blood, and decreased heart and kidney function. Improving the symptoms of poor appetite associated with chronic renal failure is conducive to fundamentally improving the overall immune function of patients, thereby achieving the effect of treating chronic renal failure. Therefore, it is of great significance to develop a Chinese medicine composition that can treat chronic renal failure with poor appetite. Summary of the invention

[0004] The purpose of the present invention is to provide a Chinese medicine composition for treating chronic renal failure with poor appetite, and a preparation method and application thereof, so as to provide a new Chinese medicine composition for treating chronic renal failure with poor appetite.

[0005] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0006] The invention provides a traditional Chinese medicine composition for treating chronic renal failure with poor appetite. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 24-36 parts of atractylodes macrocephala, 16-24 parts of raw astragalus, 12-18 parts of tuckahoe, 12-18 parts of stir-fried chicken gizzard lining, 8-12 parts of perilla stem, 6-10 parts of ginseng, 4-6 parts of liquorice and 1-3 parts of coptis root.

[0007] Preferably, the Chinese medicine composition comprises the following raw materials in parts by weight: 26-34 parts of Atractylodes macrocephala, 18-22 parts of raw Astragalus, 13-17 parts of Poria, 13-17 parts of stir-fried Chicken Gizzard Stone, 9-11 parts of Sophora flavescens, 7-9 parts of ginseng, 4.5-5.5 parts of licorice and 1.5-2.5 parts of Coptis chinensis.

[0008] Preferably, the fried chicken's gizzard lining is obtained by mixing chicken's gizzard lining with dry river sand and then frying until light yellow.

[0009] The invention provides a method for preparing the Chinese medicine composition, which comprises mixing a formula amount of Chinese medicine composition raw materials with water, decocting the mixture, separating the solid from the liquid, and taking the liquid part to obtain the Chinese medicine composition.

[0010] Preferably, the mass volume ratio of the raw materials of the traditional Chinese medicine composition when mixed with water is 0.8-1.2 g:16-24 mL.

[0011] Preferably, the temperature during the decoction is 90-110° C., the time is 40-80 min, and the number of decoctions is 2-4 times.

[0012] Preferably, the solid-liquid separation method is filtration.

[0013] The present invention provides a use of the Chinese medicine composition or the Chinese medicine composition prepared according to the method in preparing a medicine for treating chronic renal failure with poor appetite.

[0014] Preferably, the dosage form of the drug includes oral solution, granules, tablets and pills.

[0015] Compared with the prior art, the present invention has the following beneficial effects:

[0016] The present invention combines traditional Chinese medicine theory to provide a Chinese medicine composition with the effects of strengthening the spleen and eliminating dampness, regulating qi and stimulating appetite. The Chinese medicine raw materials in the Chinese medicine composition cooperate with each other, have good therapeutic effects on the symptoms of poor appetite associated with chronic renal failure, can significantly improve the condition of poor appetite, promote the body's absorption and utilization of nutrients in food, and improve small intestinal motility. The Chinese medicine composition provided by the present invention can improve the symptoms of spleen and stomach deficiency and coldness in patients with chronic renal failure and poor appetite, and has excellent clinical application prospects. DETAILED DESCRIPTION

[0017] The invention provides a traditional Chinese medicine composition for treating chronic renal failure with poor appetite. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 24-36 parts of atractylodes macrocephala, 16-24 parts of raw astragalus, 12-18 parts of tuckahoe, 12-18 parts of stir-fried chicken gizzard lining, 8-12 parts of perilla stem, 6-10 parts of ginseng, 4-6 parts of liquorice and 1-3 parts of coptis root.

[0018] Atractylodes: bitter, sweet and warm in nature, and enters the spleen and stomach meridians; sweet is tonic and diuretic, bitter, warm and dry, and is mainly used to warm and nourish the body, and can also remove dampness; it is good at tonifying Qi and strengthening the spleen, drying dampness and promoting diuresis, stopping sweating, and calming the fetus, and treats spleen and stomach Qi deficiency, spleen deficiency edema, phlegm and fluid, spontaneous sweating due to superficial deficiency, and fetal movement disorder.

[0019] Raw Astragalus: sweet and warm in nature, enters the lung and spleen meridians; has the effects of tonifying Qi and consolidating the exterior, promoting diuresis and expelling toxins, discharging pus, and healing sores and promoting tissue regeneration; used for Qi deficiency and fatigue, poor appetite and loose stools, sinking of Qi in the middle, long-term diarrhea and prolapse of the anus, bloody stool and metrorrhagia, spontaneous sweating due to exterior deficiency, edema due to Qi deficiency, carbuncles that are difficult to heal, long-term ulcers that do not heal, blood deficiency and jaundice, internal heat and thirst, etc.

[0020] Poria: sweet, light and neutral in nature, and enters the heart, lung, spleen and kidney meridians; has the effects of dissipating dampness and promoting diuresis, strengthening the spleen and eliminating dampness, calming the mind and tranquilizing the nerves; used for difficulty urinating, vomiting, diarrhea, palpitations, insomnia and forgetfulness, etc.

[0021] Fried Chicken Gizzard Stone: sweet and neutral in nature, enters the spleen, stomach, small intestine and bladder meridians; has the effects of strengthening the stomach and digestion, astringing semen and stopping nocturnal emission; mainly used for vomiting, diarrhea, indigestion, infantile malnutrition, enuresis and spermatorrhea.

[0022] Su Geng: Also known as Perilla stem, it is pungent and warm in nature, and enters the lung and spleen meridians; it has the effects of regulating qi, relieving fullness, relieving pain, and calming the fetus; it is used for chest and diaphragm fullness, epigastric pain, belching and vomiting, and fetal movement disorder.

[0023] Ginseng: sweet, slightly bitter, slightly warm, and enters the spleen, lung, heart, and kidney meridians; it has the effects of replenishing qi and strengthening the body, replenishing the spleen and lungs, replenishing qi and producing body fluid, calming the mind and improving intelligence.

[0024] Licorice: sweet and neutral in nature, it enters the heart, lung, spleen and stomach meridians; it has the functions of replenishing qi and tonifying the middle, removing phlegm and relieving cough, detoxifying, relieving pain and alleviating the properties of medicine.

[0025] Coptis chinensis: bitter and cold in nature, and enters the heart, spleen, stomach, liver, gallbladder, and large intestine meridians; has the effects of clearing away heat and dampness, purging fire and detoxifying; used for damp-heat and fullness, vomiting and acid regurgitation, diarrhea, restlessness and insomnia, and palpitations.

[0026] In the present invention, the Chinese medicine composition includes the following raw materials in parts by weight: 26-34 parts of Atractylodes macrocephala, 18-22 parts of raw Astragalus, 13-17 parts of Poria, 13-17 parts of stir-fried chicken gizzard lining, 9-11 parts of Sophora flavescens, 7-9 parts of ginseng, 4.5-5.5 parts of licorice and 1.5-2.5 parts of Coptis chinensis.

[0027] In the present invention, the Chinese medicine composition preferably includes the following raw materials in parts by weight: 28-32 parts of Atractylodes macrocephala, 19-21 parts of raw Astragalus, 14-16 parts of Poria, 14-16 parts of stir-fried chicken gizzard lining, 9.5-10.5 parts of Sophora flavescens, 7.5-8.5 parts of ginseng, 4.7-5.3 parts of licorice and 1.8-2.2 parts of Coptis chinensis.

[0028] In the present invention, the Chinese medicine composition further preferably includes the following raw medicines in parts by weight: 30 parts of Atractylodes macrocephala, 20 parts of raw Astragalus, 15 parts of Poria, 15 parts of stir-fried Chicken Gizzard Stone, 10 parts of Sophora flavescens, 8 parts of Ginseng, 5 parts of Licorice and 2 parts of Coptis chinensis.

[0029] In the present invention, the fried chicken's gizzard lining is obtained by mixing chicken's gizzard lining with dry river sand and then frying until light yellow.

[0030] In the present invention, the mass ratio of the chicken's gizzard lining and dry river sand when mixed is 1:40-60, preferably 1:45-55, and more preferably 1:50.

[0031] In the present invention, when the dry river sand is fried to a temperature of 180-220°C, chicken's gizzard lining is added for frying. Preferably, when the dry river sand is fried to a temperature of 190-210°C, chicken's gizzard lining is added for frying. More preferably, when the dry river sand is fried to a temperature of 200°C, chicken's gizzard lining is added for frying.

[0032] In the present invention, the particle size of the dry river sand is 0.8 to 1.2 mm, preferably 0.9 to 1.1 mm, and more preferably 1 mm.

[0033] The invention provides a method for preparing the Chinese medicine composition, which comprises mixing a formula amount of Chinese medicine composition raw materials with water, decocting the mixture, separating the solid from the liquid, and taking the liquid part to obtain the Chinese medicine composition.

[0034] In the present invention, the mass volume ratio of the raw materials of the traditional Chinese medicine composition and water when mixed is 0.8-1.2 g:16-24 mL, preferably 0.9-1.1 g:18-22 mL, and more preferably 1 g:20 mL.

[0035] In the present invention, the decoction temperature is 90-110°C, preferably 95-105°C, more preferably 100°C, the decoction time is 40-80 min, preferably 50-70 min, more preferably 60 min; the decoction is performed 2-4 times, preferably 3 times.

[0036] In the present invention, the solid-liquid separation method is filtration.

[0037] In the present invention, the obtained liquid portion is also dried.

[0038] The present invention provides a use of the Chinese medicine composition or the Chinese medicine composition prepared according to the method in preparing a medicine for treating chronic renal failure with poor appetite.

[0039] In the present invention, the dosage forms of the drug include oral liquid, granules, tablets and pills.

[0040] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0041] Example 1

[0042] A method for preparing a Chinese medicine composition for treating chronic renal failure with poor appetite, comprising the following steps:

[0043] (1) frying 50 parts by weight of dry river sand with a particle size of about 1 mm at a temperature of 200° C., adding 1 part by weight of chicken's gizzard lining and rapidly frying the chicken's gizzard lining until it turns light yellow (frying time is about 60 seconds), thereby obtaining fried chicken's gizzard lining;

[0044] (2) By weight, 24 parts of Atractylodes macrocephala, 16 parts of raw Astragalus, 12 parts of Poria, 12 parts of stir-fried chicken gizzard lining, 8 parts of Sophora flavescens, 6 parts of Ginseng, 4 parts of Licorice and 1 part of Coptis chinensis were mixed to obtain a raw material for a Chinese medicine composition;

[0045] (3) The raw material of the Chinese medicine composition obtained in step (2) is mixed with water in a mass volume ratio of 1 g:20 mL, and decocted at a temperature of 90° C. for 60 min. After the decocting is completed, the first decoction liquid is filtered out with gauze, and water is added to the residue and the decocting is repeated twice. The decoction liquids obtained by the three decoctions are mixed and dried at 80° C. to a water content of 10%, thereby obtaining a Chinese medicine composition.

[0046] Example 2

[0047] A method for preparing a Chinese medicine composition for treating chronic renal failure with poor appetite, comprising the following steps:

[0048] (1) frying 50 parts by weight of dry river sand with a particle size of about 1 mm at a temperature of 200° C., adding 1 part by weight of chicken's gizzard lining and rapidly frying the chicken's gizzard lining until it turns light yellow (frying time is about 60 seconds), thereby obtaining fried chicken's gizzard lining;

[0049] (2) By weight, 36 parts of Atractylodes macrocephala, 24 parts of raw Astragalus, 18 parts of Poria, 18 parts of stir-fried chicken gizzard lining, 12 parts of Sophora flavescens, 10 parts of Ginseng, 6 parts of Licorice and 3 parts of Coptis chinensis were mixed to obtain a raw material for a Chinese medicine composition;

[0050] (3) The raw material of the Chinese medicine composition obtained in step (2) is mixed with water in a mass volume ratio of 1 g:20 mL, and decocted at a temperature of 110° C. for 60 min. After the decocting is completed, the first decoction liquid is filtered out with gauze, and water is added to the residue and the decocting is repeated twice. The decoction liquids obtained by the three decoctions are mixed and dried at 80° C. to a water content of 10%, thereby obtaining a Chinese medicine composition.

[0051] Example 3

[0052] A method for preparing a Chinese medicine composition for treating chronic renal failure with poor appetite, comprising the following steps:

[0053] (1) frying 50 parts by weight of dry river sand with a particle size of about 1 mm at a temperature of 200° C., adding 1 part by weight of chicken's gizzard lining and rapidly frying the chicken's gizzard lining until it turns light yellow (frying time is about 60 seconds), thereby obtaining fried chicken's gizzard lining;

[0054] (2) By weight, 30 parts of Atractylodes macrocephala, 20 parts of raw Astragalus, 15 parts of Poria, 15 parts of stir-fried chicken gizzard lining, 10 parts of Sophora flavescens, 8 parts of Ginseng, 5 parts of Licorice and 2 parts of Coptis chinensis were mixed to obtain a raw material for a Chinese medicine composition;

[0055] (3) The raw material of the Chinese medicine composition obtained in step (2) is mixed with water in a mass volume ratio of 1 g:20 mL, and decocted at a temperature of 100° C. for 60 min. After the decocting is completed, the first decoction liquid is filtered out with gauze, and water is added to the residue and the decocting is repeated twice. The decoction liquids obtained by the three decoctions are mixed and dried at 80° C. to a water content of 10%, thereby obtaining a Chinese medicine composition.

[0056] Comparative Example 1

[0057] The difference between this comparative example and Example 3 is that different raw materials of the Chinese medicine composition are used. The raw materials of the Chinese medicine composition used in this comparative example are obtained by mixing 30 parts of raw astragalus, 20 parts of Poria, 15 parts of Atractylodes macrocephala, 10 parts of costus root, 8 parts of ginseng, 5 parts of Citrus aurantium and 3 parts of licorice in parts by mass; the remaining steps are the same as in Example 3.

[0058] Test example

[0059] Experimental animals: 50 SD male rats weighing 180-220 g were selected and randomly divided into 5 groups (model control group, Example 1-3 groups and Comparative Example 1 group), with 10 rats in each group. Modeling was performed after one week of adaptive feeding.

[0060] Modeling method: The model control group rats were gavaged once a day with a 200 mg / kg adenine suspension; the rats in the Example 1-3 group and the Comparative Example 1 group were gavaged once a day with a 200 mg / kg adenine suspension, and 4 hours after the suspension gavage, the Chinese medicine composition prepared in the Examples 1-3 and the Comparative Example 1 was gavaged once a day, and the gavage amount of the Chinese medicine composition was 0.2 g / rat. The experiment was carried out for a total of 4 weeks, and the rats were free to drink water and eat during the experiment.

[0061] The changes in the rats were observed before the start of the experiment, on the 7th, 14th, 21st and 28th days of the experiment, and the average body weight of the rats in each treatment group was calculated. The average body weight results of the rats in each treatment group are shown in Table 1.

[0062] Table 1 Average body weight of rats in each treatment group during the experiment (g)

[0063] Treatment Group Before the test Test 7d Test day 14 Test day 21 Test day 28 Model control group 199.7 214.2 209.5 197.6 190.8 Example 1 Group 201.6 223.5 217.4 219.3 226.6 Example 2 Group 200.1 222.8 216.7 219.0 224.9 Example 3 Group 201.3 225.3 220.1 223.2 230.2 Comparative Example 1 198.8 218.7 211.2 211.5 219.8

[0064] Observe the changes during the rat test and find that the model control group rats began to show mental depression, less food, weight loss, reduced activity, polyuria and other phenomena around 14d after gavage, indicating that the rat model of chronic renal failure with poor appetite was successfully established. The rats in the embodiment 1 to 3 groups and the comparative example 1 group also began to show mental depression, less food, weight loss, reduced activity, polyuria and other phenomena around 14d after gavage, but one week later (i.e., around 21d after gavage), the activity of the rats increased significantly, the food intake increased, and the polyuria phenomenon decreased significantly. It can be seen from the data recorded in Table 1 that the Chinese medicine composition prepared by the present invention can significantly improve the weight loss of rats caused by chronic renal failure compared to the comparative example 1 group, and is conducive to promoting the absorption and utilization of nutrients in food by rats.

[0065] The inventors also tested the 24-hour food intake and water intake of rats in each treatment group before the start of the experiment (the last day of adaptive feeding) and after the end of the experiment (the first day after the end of the experiment). The specific method is: sufficient food and water are placed in the cage, the rats are placed in the cage for 24 hours, and the food and water consumption is measured, that is, the 24-hour food intake and water intake of the rats. The measurement results are shown in Table 2.

[0066] Table 2 The results of food intake and water intake of rats in each treatment group before and after the experiment (n=5)

[0067]

[0068]

[0069] As can be seen from Table 2, the food intake and water intake of the rats in the model control group were significantly reduced after the experiment, indicating that the rats in the chronic renal failure model constructed had obvious symptoms of poor appetite; compared with the model control group and the comparative example 1 group, the food intake and water intake of the rats in the Example 1 to 3 groups were significantly increased, indicating that the Chinese medicine composition prepared by the present invention has a significant effect of improving and treating the symptoms of poor appetite.

[0070] After the experiment, 5 rats were taken from each treatment group to detect the small intestinal propulsion rate. The specific method was as follows: after fasting the rats for 24 hours but not depriving them of water, they were gavaged with an equal amount of activated carbon. After gavage for 30 minutes, the rats were killed by cervical dislocation, the abdominal cavity was opened and the mesentery was separated, the small intestine was cut and placed on a platform, and the small intestine was gently pulled into a straight line. The total length of the small intestine and the length from the pylorus to the front of the activated carbon were measured, and the small intestinal propulsion rate was calculated (small intestinal propulsion rate = length from the pylorus to the front of the activated carbon / total length of the small intestine × 100%). The results are shown in Table 3.

[0071] Table 3 Calculation results of small intestinal propulsion rate of rats in each treatment group (n=5)

[0072] Treatment Group Small intestinal propulsion rate (%) Model control group 52.83 Example 1 Group 83.54 Example 2 Group 81.58 Example 3 Group 84.04 Comparative Example 1 73.26

[0073] As can be seen from Table 3, compared with the model control group, Example 1-3 groups and Comparative Example 1 group can significantly promote the intestinal motility of rats; compared with Comparative Example 1 group, Example 1-3 groups have more obvious function of promoting intestinal motility of rats. This shows that the Chinese medicine composition prepared by the present invention has the ability to significantly promote intestinal motility in rats with chronic renal failure and poor appetite.

[0074] As can be seen from the above examples, the present invention provides a Chinese medicine composition capable of treating chronic renal failure with poor appetite, which can significantly increase the food intake, water intake, and absorption and utilization of nutrients in food of rats with chronic renal failure with poor appetite, and promote small intestinal peristalsis. It can be seen that the Chinese medicine composition prepared by the present invention achieves the effect of treating chronic renal failure with poor appetite, and each Chinese medicine raw material cooperates with each other, has a certain synergistic effect, is conducive to fundamentally improving the body's immune function, and has excellent clinical application prospects.

[0075] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating chronic renal failure with poor appetite, characterized in that: The Chinese medicine composition comprises the following raw materials in parts by weight: 24-36 parts of Atractylodes macrocephala, 16-24 parts of raw Astragalus, 12-18 parts of Poria, 12-18 parts of stir-fried chicken gizzard lining, 8-12 parts of Sophora flavescens, 6-10 parts of ginseng, 4-6 parts of liquorice and 1-3 parts of Coptis chinensis.

2. The Chinese medicine composition according to claim 1, characterized in that The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 26-34 parts of Atractylodes macrocephala, 18-22 parts of raw Astragalus, 13-17 parts of Poria, 13-17 parts of stir-fried chicken gizzard lining, 9-11 parts of Sophora flavescens, 7-9 parts of ginseng, 4.5-5.5 parts of liquorice and 1.5-2.5 parts of Coptis chinensis.

3. The Chinese medicine composition according to claim 1 or 2, characterized in that: The stir-fried chicken's gizzard lining is prepared by mixing chicken's gizzard lining with dry river sand and then stir-frying until light yellow.

4. A method for preparing the Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The Chinese medicine composition is prepared by mixing the raw materials of the Chinese medicine composition in a prescribed amount with water, boiling the mixture, separating the solid from the liquid, and taking the liquid portion to obtain the Chinese medicine composition.

5. The method according to claim 4, characterized in that The mass volume ratio of the raw materials of the traditional Chinese medicine composition when mixed with water is 0.8-1.2 g:16-24 mL.

6. The method according to claim 4, characterized in that The temperature during the decoction is 90-110° C., the time is 40-80 min, and the number of decoctions is 2-4 times.

7. The method according to claim 4, characterized in that The solid-liquid separation method is filtration.

8. Use of the Chinese medicine composition according to any one of claims 1 to 3 or the Chinese medicine composition prepared by the method according to any one of claims 4 to 7 in the preparation of a medicament for treating chronic renal failure with poor appetite.

9. The use according to claim 8, characterized in that The dosage forms of the drug include oral liquid, granules, tablets and pills.

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