Traditional Chinese medicine composition for treating atrophic gastritis

Abstract

The invention discloses a traditional Chinese medicine composition for treating atrophic gastritis, and particularly relates to the field of traditional Chinese medicine compositions. Comprising the following raw materials: 15-50 parts of astragalus membranaceus, 10-30 parts of ginseng, 15-50 parts of bighead atractylodes rhizome, 10-50 parts of poria cocos, 10-50 parts of Chinese yam, 10-60 parts of coix seed, 6-30 parts of rhizoma pinellinae praeparata, 6-30 parts of pericarpium citri reticulatae, 10-30 parts of rhizoma atractylodis, 7-30 parts of agastache rugosus, 6-30 parts of Mitsubishi, 6-30 parts of curcuma zedoary, 3-10 parts of pseudo-ginseng, 10-30 parts of patrinia, 10-30 parts of dandelion, 10-30 parts of malt, 10-30 parts of massa medicata fermentata fujianensis, 10-30 parts of hawthorn, 5-15 parts of fructus amomi, 6-30 parts of elecampane and 5-30 parts and 10-30 parts of radix curcumae. By adopting the technical scheme, the problem that an existing Chinese patent medicine cannot treat patients except for spleen deficiency, blood stasis and stomach yin deficiency is solved, and the traditional Chinese medicine composition for treating the atrophic gastritis is enriched.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine compositions, and in particular to a traditional Chinese medicine composition for treating atrophic gastritis. Background Art

[0002] The prevalence of chronic atrophic gastritis is approximately 15%. A large-scale cross-sectional survey in China showed that among 88,912 patients diagnosed with chronic gastritis by endoscopy, the proportions of chronic atrophic gastritis and chronic non-atrophic gastritis were 17.7% and 82.3%, respectively. The proportion of chronic atrophic gastritis diagnosed by endoscopy was lower than that diagnosed by histology (25.3%). A meta-analysis showed that, using histology as the "gold standard," the accuracy of endoscopy in diagnosing chronic atrophic gastritis was only 50.3%. The estimated prevalence of chronic atrophic gastritis in the Chinese population is greater than 20%. Currently, experts on the management of precancerous conditions and lesions of the gastric mucosa indicate that severe chronic atrophic gastritis involving the entire stomach, with or without intestinal metaplasia (intestinal glandular metaplasia, intestinal metaplasia), carries a higher risk of gastric cancer. Atrophic gastritis poses a serious threat to human health. Current Western medical treatments for atrophic gastritis, aside from etiological and symptomatic treatments, lack the means to reverse atrophy and prevent the progression of atrophy to gastric cancer.

[0003] Traditional Chinese medicine (TCM) has certain advantages in treating this disease. Currently, two Chinese patent medicines for atrophic gastritis on the market are Morodan and Weifuchun. Weifuchun, composed of red ginseng, fragrant tea leaves, and fructus aurantii, has the effects of strengthening the spleen and replenishing qi, promoting blood circulation and detoxifying, and is suitable for patients with spleen deficiency and blood stasis. Morodan, composed of lily bulbs, ophiopogon japonicus, dendrobium candidum, Scrophularia ningpoensis, Panax notoginseng, and angelica sinensis, has the effects of soothing the stomach and relieving adverse reactions, strengthening the spleen and relieving bloating, and unblocking meridians and relieving pain, and is suitable for patients with stomach yin deficiency. In clinical practice, many patients experience uncontrolled symptoms and inability to reverse atrophy after using these two drugs. The reason for this is that these drugs are only suitable for patients with the corresponding syndromes, and patients outside of these two syndromes still have no other available treatments. Summary of the Invention

[0004] The present invention aims to provide a traditional Chinese medicine composition for treating atrophic gastritis, which solves the problem that existing traditional Chinese medicines cannot treat patients with diseases other than spleen deficiency and blood stasis and stomach yin deficiency.

[0005] In order to achieve the above object, the technical solution of the present invention is as follows: A traditional Chinese medicine composition for treating atrophic gastritis, comprising the following raw materials: 15-50 parts of astragalus, 10-30 parts of ginseng, 15-50 parts of white atractylodes, 10-50 parts of poria, 10-50 parts of yam, 10-60 parts of coix seed, 6-30 parts of pinellia, 6-30 parts of tangerine peel, 10-30 parts of atractylodes, 7-30 parts of patchouli, 6-30 parts of safflower, 6-30 parts of wormwood, 6-30 parts of curcuma, 3-10 parts of notoginseng, 10-30 parts of patrinia herb, 10-30 parts of dandelion, 10-30 parts of malt, 10-30 parts of jianqu, 10-30 parts of hawthorn, 5-15 parts of amomum, 6-30 parts of costus root, 5-30 parts of roasted licorice, and 10-30 parts of turmeric.

[0006] Principle and effect of the technical solution: This solution uses Astragalus, Ginseng and Atractylodes as the main ingredients to strengthen the spleen and replenish Qi, protect the spleen and stomach. Astragalus replenishes Qi and strengthens the spleen, removes toxins and promotes tissue regeneration, is sweet and warm, and is good at entering the spleen and stomach. It is an important medicine for tonifying the middle and replenishing Qi; Ginseng replenishes the spleen and lung Qi, and strengthens the Qi-tonifying effect of Astragalus. "Compendium of Materia Medica" records that "Ginseng replenishes the middle and replenishes Qi, harmonizes the spleen and stomach, and eliminates thirst. It is very safe to use it to regulate and replenish the body when the Qi in the middle is slightly deficient." Atractylodes macrocephala is sweet, warm and has a thick flavor. It is the yin in the yang and can rise or fall. It enters the spleen and stomach meridians and is an essential medicine for tonifying the spleen and stomach, dispersing dampness and removing numbness, and digesting food and removing abdominal distension. Combined with Astragalus membranaceus and ginseng, it tonifies the spleen and replenishes qi, and restores the normal function of the spleen and stomach. "Compendium of Materia Medica" says, "There is no better medicine for tonifying the spleen and stomach. When the earth is prosperous, the clear qi is good at rising, and the essence is delivered upward, the turbid qi is good at removing, and the dregs are transported downward. Therefore, it is indispensable for those who vomit and have diarrhea." "Compendium of Materia Medica" says, "It tonifies the spleen qi, dries out spleen dampness, warms the spleen and produces body fluid, and invigorates food and digests grains. It is the most important medicine for tonifying the spleen qi."Poria, tangerine peel, yam, coix seed, atractylodes, patchouli, and pinellia are the ministers, which can dispel dampness and detoxify. Poria strengthens the spleen, promotes diuresis and penetrates dampness. It tastes sweet and light. Light can penetrate, sweet can nourish, and it can dispel evil and strengthen the body. "Shennong's Herbal Classic" records that "it treats chest and flank reverse qi, heart pain, cold and heat, and fullness. Long-term use can calm the soul, nourish the mind, prevent hunger, and prolong life"; tangerine peel strengthens the spleen, regulates qi and dries dampness, and restores the ascending and descending of the spleen and stomach. "Compendium of Materia Medica" records that "it can cure all diseases by taking its function of regulating qi and drying dampness. It can nourish with tonics, purge with laxatives, ascend with ascending drugs, and descend with descending drugs"; yam replenishes qi and nourishes yin, nourishes the lungs and spleen, and eliminates the source of dampness. "Shennong's Herbal Classic" records that it "tonifies the middle, replenishes qi and strength ", grow muscles", "Compendium of Materia Medica" "benefit kidney qi, nourish spleen and stomach"; coix seed clears heat and dampness to detoxify, "Shennong's Herbal Classic" records "Yangming medicine, can strengthen spleen and stomach"; Atractylodes lancea dries dampness and strengthens spleen, dispels wind and cold, bitter and warm to remove dampness and turbidity, spicy and fragrant to harmonize spleen and stomach, "Shennong's Herbal Classic": "It is used to treat wind, cold and dampness, dead muscle spasm and jaundice, and can be taken as decoction for a long time to lighten the body and prolong life without hunger" "Ming Yi Bie Lu": "It eliminates acute pain in the heart and cholera vomiting and diarrhea, warms the stomach and helps digestion"; Patchouli has a fragrant smell and is an important aromatic dampness-removing and turbidity-removing medicine. It can both remove dampness and stop vomiting. Combined with coix seed, Poria cocos and Atractylodes lancea, it strengthens the effect of removing dampness, "Ming Yi Bie Lu": "Cure wind and water poison swelling, remove bad air, treat cholera, heartache", "Compendium of Materia Medica": "Cure spleen and stomach vomiting, it is the most important medicine"; the method of Pinellia ternata drying dampness and resolving phlegm, descending the adverse vomiting, eliminating lumps and dispersing knots, resolving turbidity and descending qi, "Main Treatment Secret" says: "Dry stomach dampness, resolve phlegm, benefit the spleen and stomach qi, reduce swelling and disperse knots, remove phlegm in the chest, "Famous Doctors' Prescriptions": "It eliminates phlegm heat and fullness in the heart and diaphragm, cough and shortness of breath, acute pain under the heart, hard lumps, vomiting and vomiting due to seasonal qi, and eliminates carbuncle swelling". Costus root, dandelion, patina, zedoaria, malt, chicken gizzard, white peony root, and turmeric are used as adjuvants. Costus root promotes qi and relieves pain, strengthens the spleen and digests food, and unblocks qi stagnation in the spleen and stomach. "Rihuazi Materia Medica" records: "Cure all qi in the heart and abdomen =The book "Compendium of Materia Medica" records that "it can relieve qi and relieve fullness, and is an important medicine for the triple burner qi"; dandelion clears heat and detoxifies, reduces swelling and disperses knots; Patrinia scabra clears heat and detoxifies, eliminates carbuncle and discharges pus, removes blood stasis and relieves pain; Snake tongue grass clears heat and detoxifies; White peony root softens the liver and relieves pain, nourishes blood and restrains yin, and prevents excessive dampness from causing yin deficiency and dryness. "Compendium of Materia Medica" records that "it can treat abdominal pain caused by evil qi, relieve pain, promote urination, and replenish qi"; Curcuma zedoaria breaks blood and promotes qi circulation, eliminates accumulation and relieves pain, enters both the blood and qi, can break blood and disperse blood stasis, eliminate symptoms and resolve accumulation, promote qi circulation and relieve pain, and is paired with astragalus and ginseng to both eliminate and supplement, while malt and chicken gizzard lining can help digestion; Curcuma zedoaria promotes blood circulation and relieves pain, promotes qi circulation and relieves depression. Licorice is the messenger to harmonize the various medicines. The whole formula can eliminate evil without harming the body, and strengthen the body without stagnating the evil, and can work together to strengthen the spleen and replenish qi, regulate qi and eliminate dampness, clear away heat, detoxify and disperse nodules.

[0007] Furthermore, it also includes 10-30 parts of Bupleurum Root and 15-45 parts of White Peony Root.

[0008] Furthermore, it also comprises 15-50 parts of corrugated paper, 30-60 parts of cuttlebone, and 10-30 parts of Fritillaria thunbergii.

[0009] Furthermore, it also includes 3-10 parts of Coptis chinensis and 10-30 parts of Scutellaria baicalensis.

[0010] Furthermore, it also includes 4-30 parts of dried ginger.

[0011] Furthermore, it also includes 3-15 parts of Citrus aurantium and 10-30 parts of Magnolia officinalis.

[0012] Another technical solution provided by the present invention is to use any of the above-mentioned traditional Chinese medicine compositions for treating atrophic gastritis to prepare a medicament for atrophic gastritis.

[0013] Compared with the existing technology, this solution has the following beneficial effects:

[0014] This regimen can significantly improve major clinical symptoms such as epigastric pain, epigastric fullness, epigastric obstruction, heartburn, acid reflux, belching, stomach cold, poor appetite, and noisy stomach. It can also reduce the scores of various mucosal lesion signs under gastroscopy, improve pathologies such as intestinal metaplasia, dysplasia, glandular atrophy, chronic inflammation, and activity, increase the levels of G-17, PGⅠ, and PGⅡ, block the development of chronic atrophic gastritis to gastric cancer, and has a definite effect in treating chronic atrophic gastritis. DETAILED DESCRIPTION

[0015] The present invention will be further described in detail below through specific embodiments:

[0016] Example

[0017] A traditional Chinese medicine composition for treating atrophic gastritis comprises the following raw materials: 15-50 parts of astragalus, 10-30 parts of ginseng, 15-50 parts of atractylodes, 10-50 parts of poria, 10-50 parts of yam, 10-50 parts of coix seed, 6-30 parts of pinellia, 6-30 parts of dried tangerine peel, 10-30 parts of atractylodes, 7-30 parts of patchouli, 6-30 parts of safflower, 6-30 parts of curcuma, 3-10 parts of notoginseng, 10-30 parts of patrinia herb, 10-30 parts of dandelion, 10-30 parts of malt, 10-30 parts of jianqu, 10-30 parts of hawthorn, 5-15 parts of amomum, 6-30 parts of costus root, 5-30 parts of roasted liquorice, and 10-30 parts of turmeric.

[0018] In this protocol, there is no significant gender difference in CAG patients. The incidence rate increases with age, with the highest number of patients in their 50s and 60s. Clinical symptoms are limited, primarily presenting with epigastric discomfort, fullness, dull pain, hiccups, heartburn, chest tightness, loss of appetite, diarrhea, constipation, dry mouth, and a bitter taste in the mouth. We believe that the incidence of gastric cancer remains high, and that CAG is a precancerous lesion. Treating CAG can prevent the development of gastric cancer. Western medicine has no effective treatment for CAG, but Traditional Chinese Medicine offers significant advantages. The Suwen (Suwen) Treatise on the Original Nature of Ancient Things states: "In ancient times, those who knew the truth followed the laws of yin and yang, and were in harmony with the art of numbers. They ate and drank in moderation, had regular daily routines, and did not overwork. Therefore, their bodies and spirits were in harmony, and they lived out their natural lives, passing away at the age of one hundred. People today are not like that. They drink alcohol and take extravagance as their norm. They go to bed drunk, exhaust their essence with lust, and dissipate their true energy. They do not know how to maintain a full state of mind, do not control their spirits at the right time, and only seek to please their hearts. They go against the joy of life and have no regular daily routines. Therefore, they become weak by the age of fifty." The accelerated pace of life in today's society, increased work pressure, worsening environmental pollution, unbalanced diets, and changes in lifestyle have changed the spectrum of diseases. An unbalanced diet, overeating, and excessive dieting damage the spleen and stomach's function of transporting and transforming. Uncontrolled desires, staying up late, working overtime, and overwork damage the spleen, damaging the acquired essence and causing diseases. Based on the above analysis, starting from the actual clinical practice of traditional Chinese medicine, giving full play to the advantages of traditional Chinese medicine's holistic treatment and "preventive treatment", paying attention to the treatment of CAG, preventing it before it gets sick, and preventing its recurrence and canceration are the needs of current society and also the problems that need to be solved in the clinical practice of traditional Chinese medicine.

[0019] The disease is located in the spleen and stomach. The spleen and stomach are weak due to old age, long-term illness, abnormal hunger and satiety, and infection with the six evils without timely treatment. The spleen fails to function properly, food enters the stomach, but the water and grain cannot be digested and stagnate in the middle burner. The Qi is blocked and not unblocked, resulting in fullness. The spleen cannot disperse the body fluid, and the essence cannot be transported to the upper part, but instead stagnates in the middle. Food becomes stagnant and water becomes damp. The dampness stays in the spleen and stomach, and over time it turns into heat and becomes damp-heat in the spleen and stomach. The damp-heat evil accumulates for a long time and is not transformed into dampness toxins. The dampness toxins block the stomach meridian, causing stasis in the stomach meridian, and granular hyperplasia and atrophy of the gastric mucosa can be seen. This disease is based on spleen and stomach deficiency, which is the pathological basis of this disease. Once there is an irregular diet, invasion of exogenous pathogens, or emotional injury on the basis of spleen and stomach deficiency, pathological changes such as qi stagnation, damp-heat, blood stasis, and turbid phlegm may occur. Clinically, it manifests as spleen deficiency and weakness, spleen and stomach qi stagnation, spleen and stomach damp-heat, blood stasis in the stomach meridians, and insufficient stomach yin. Most patients are suffering from spleen and stomach deficiency, spleen and stomach qi stagnation, and spleen and stomach damp-heat. Often, several syndromes occur simultaneously, with two syndromes occurring simultaneously. Each syndrome often overlaps with another. This disease is based on spleen and stomach deficiency, with internal dampness and toxins as the main symptom. During the course of the disease, deficiency and excess are often mixed, and multiple pathological states coexist. Spleen and stomach deficiency and internal dampness and toxins run through the entire course of this disease. Treatment must be combined with strengthening the body's resistance and dispelling pathogens. Invigorating the spleen and stomach, removing dampness and toxins, and removing blood stasis and unblocking the meridians run through the entire process. Only when the pathogens are eliminated can the body be at peace. Atrophic gastritis is caused by qi deficiency and blood stasis in the collaterals, and phlegm and turbidity blocking the stomach collaterals. Treatment requires strengthening the spleen and replenishing qi, removing blood stasis and unblocking the collaterals, and detoxifying and clearing turbidity. The method of strengthening the spleen and replenishing qi, removing blood stasis and unblocking the collaterals, and detoxifying and clearing turbidity is proposed to treat this disease.

[0020] Observation on the therapeutic effect of compound Chinese medicine composition in treating chronic atrophic gastritis:

[0021] 1. Research subjects:

[0022] 1.1 Case Source:

[0023] All case data were collected from patients with chronic atrophic gastritis who met the inclusion and exclusion criteria and were admitted to the outpatient and inpatient department of the Department of Gastroenterology at Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine between July 2020 and June 2023. A total of 128 patients were included, including 58 males aged 30 to 72 years (53.6 ± 18.3) years; and 70 females aged 39 to 71 years (55.3 ± 16.02) years.

[0024] 1.2 Diagnostic criteria:

[0025] 1.2.1 Western medicine diagnostic criteria:

[0026] The endoscopic and pathological diagnostic criteria for chronic atrophic gastritis with or without mild or moderate dysplasia were referred to the Consensus on Chronic Gastritis in China (2017, Shanghai) and the Guidelines for Clinical Research of New Chinese Medicines (2002).

[0027] ①Clinical manifestations:

[0028] The clinical manifestations of CAG vary widely from patient to patient, and some patients may experience no specific discomfort. The most common clinical manifestations include upper abdominal distension and dull pain, sometimes accompanied by heartburn and acid reflux. In severe cases, symptoms such as loss of appetite and fatigue may also occur.

[0029] ②Endoscopic diagnosis:

[0030] Under CAG endoscopy, the mucosa can be seen to be alternating red and white, with the white phase being the main phase. The folds are flattened or even disappear, and some mucosal blood vessels are exposed; it may be accompanied by mucosal granules or nodules.

[0031] ③Pathological diagnosis:

[0032] Gastric mucosal pathology was scored according to the "Chinese Consensus on Chronic Gastritis (2017, Shanghai)" and the New Sydney Visual Analog Scoring System. Chronic inflammation, activity, atrophy, intestinal metaplasia, and dysplasia were categorized into four levels: none, mild, moderate, and severe, with scores of 0, 1, 2, and 3, respectively. Patients underwent gastroscopy before and 6 months after treatment.

[0033] 1.3 Inclusion and Exclusion Criteria:

[0034] 1.3.1 Inclusion criteria:

[0035] ① Endoscopic and pathological diagnostic criteria were based on the "Chinese Consensus on Chronic Gastritis (2017, Shanghai)". Patients included were diagnosed with chronic atrophic gastritis with or without mild to moderate dysplasia by endoscopic and pathological examination.

[0036] ② Those who were previously diagnosed with Hp infection by breath test and whose Hp turned negative after standard eradication treatment; those who were Hp positive were included after successful eradication treatment;

[0037] ③Age 18 to 75, regardless of gender;

[0038] ④No relevant treatment drugs have been taken within one month of the visit;

[0039] ⑤ Those who are willing to take CAG Chinese herbal decoction and cooperate with CAG review.

[0040] 1.3.2 Exclusion criteria:

[0041] ① History of gastric surgery;

[0042] ② Patients with high-grade intraepithelial neoplasia (HGIN) as shown by pathological biopsy;

[0043] ③ Long-term use of nonsteroidal anti-inflammatory drugs, proton pump inhibitors, and H2 receptor blockers;

[0044] ④ Those with serious diseases that affect research evaluation, such as severe blood disease, liver disease, heart disease, kidney disease, malignant tumor, and mental illness;

[0045] ⑤ Pregnant and lactating women;

[0046] ⑥ Those who are allergic to the drugs used in this study;

[0047] 1.4 Falling off and rejection standards:

[0048] ① Those who are unable to complete the course of treatment for some reason;

[0049] ② Those who experience serious adverse reactions during medication;

[0050] ③ Those with poor compliance and difficulty in evaluating treatment efficacy.

[0051] 2.1 Treatment methods:

[0052] Atrophic gastritis Chinese medicine complex: Astragalus 15g, Ginseng 10g, Atractylodes 15g, Poria 15g, Chinese Yam 15g, Coix Seed 20g, Pinellia 9g, Tangerine Peel 10g, Atractylodes 10g, Patchouli 10g, Miscanthus 7g, Curcuma 7g, Panax Notoginseng 5g, Patrinia 15g, Taraxacum 15g, Malt 15g, Jianqu 15g, Crataegus 15g, Amomum 6g, Costus 10g, Roasted Licorice 6g, Curcuma 12g. For liver depression and qi stagnation, add Bupleurum 10g and White Peony 15g; for acid reflux and heartburn, add Coral Reticulata 20g, Cuttlebone 30g, and Fritillaria thunbergii 10g; for severe heat, add Coptis chinensis 5g and Scutellaria 12g; for severe cold, add Dried Ginger 5g; for constipation, add Citrus aurantium 3g and Magnolia officinalis 10g.

[0053] All Chinese medicines were prescribed by the outpatient department and ward of the Department of Gastroenterology of Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine, and provided by the pharmacy of Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine. They were decocted in water, 200 ml each time, and taken warm in the morning and evening after meals. The course of treatment was 12 months.

[0054] 3. Observation indicators:

[0055] 3.1 Clinical symptoms: formulated with reference to the 2017 Chinese Consensus on Chronic Gastritis.

[0056] The scores of the patients' main symptoms (epigastric pain, epigastric fullness, epigastric obstruction, heartburn, acid reflux, belching, stomach cold, poor appetite, and noisy stomach) were recorded before and after treatment and divided into 4 levels: none, mild, moderate, and severe, and assigned 0, 3, 6, and 9 points respectively.

[0057] 3.2 Semi-quantitative scoring of endoscopic signs The main endoscopic mucosal lesions were mucosal pallor, visible blood vessels, thinning of mucosal folds, rough granular changes in the mucosa, and intestinal metaplasia nodules. A quantitative grading standard was developed based on the "Endoscopic Classification and Treatment Trial Opinions for Chronic Gastritis", which were divided into normal, mild, moderate, and severe, and assigned 0, 3, 6, and 9 points, respectively. The endoscopic lesion sign scores of the gastric antrum, lesser curvature, and gastric angle, as well as the total score, were recorded before and after treatment.

[0058] 3.3 Semi-quantitative Histopathological Scoring Based on the pathological diagnostic criteria for chronic gastritis in the 2017 "Chinese Consensus on Chronic Gastritis," histological changes associated with gastric precancerous lesions, such as intestinal metaplasia, dysplasia, atrophy, and chronic inflammatory activity, were semi-quantitatively graded into four grades: none, mild, moderate, and severe. Furthermore, based on the histopathological evaluation of therapeutic efficacy in the "Consensus on the Diagnosis and Treatment of Chronic Atrophic Gastritis in Traditional Chinese Medicine," different histological variables were divided into primary variables (atrophy, atypical hyperplasia, intestinal metaplasia) and secondary variables (chronic inflammation, activity). Primary variables were assigned higher scores (0, 3, 6, and 9 points) and secondary variables were assigned lower scores (0, 1, 2, and 3 points). When multiple specimens or pathological sections from the same site had varying degrees of lesion, the more severe lesion was assigned the higher score. The total score for each variable was the sum of the primary and secondary scores. The scores for each variable and the total pathological score were recorded before and after treatment for common lesion sites (antrum, lesser curvature, and angle of the stomach).

[0059] 4. Efficacy evaluation:

[0060] 4.1 The overall efficacy is formulated in accordance with Chapter 5, Section 1 of the 2002 "Guiding Principles for Clinical Research of New Chinese Medicines".

[0061] (1) Cure: After treatment, clinical symptoms disappear, and the syndrome score decreases by ≥95%; pathological biopsy shows that atrophy, IM, and IN return to normal or disappear;

[0062] (2) Markedly effective: After treatment, the main symptoms disappear, and the symptom score decreases by ≥70%; pathological biopsy shows that atrophy, IM, and IN are reduced by 2 grades or return to normal;

[0063] (3) Effective: After treatment, the main symptoms were significantly alleviated, and the syndrome score decreased by ≥30% compared with the previous period; pathological biopsy showed that atrophy, IM and IN were alleviated;

[0064] (4) Ineffective: Symptoms and pathological biopsy showed no improvement or even worsening.

[0065] 4.2 Efficacy criteria for gastric mucosal pathology follow the modified Sydney system for grading the degree of atrophy, intestinal metaplasia, and dysplasia, as described in the "Consensus on the Diagnosis and Treatment of Chronic Atrophic Gastritis with Integrated Traditional Chinese and Western Medicine (2017)." Changes in pathological severity are categorized as progressive, stable, or improved. The effective rate of gastric mucosal pathology improvement = (cured + markedly effective + improved) / total number of cases × 100%.

[0066] 5. Research Results:

[0067] 5.1 Comparison of gastric mucosal improvement before and after treatment:

[0068]

[0069] Note: △Compared with before treatment, P<0.05.

[0070] 5.2 Comparison of pathological histological scores between the two groups before and after treatment

[0071]

[0072] Note: △Compared with before treatment, P<0.05.

[0073] 5.2 Comparison of symptom scores before and after treatment:

[0074]

[0075] Note: △Compared with before treatment, P<0.01.

[0076] 5.3 Overall efficacy

[0077]

[0078] Typical Case 1

[0079] Gao, male, 72 years old, medical record number 18342298, first visited the hospital on November 12, 2021, due to bloating for one year. The patient began to experience bloating without obvious cause one year ago, unrelated to eating, and chest tightness. He received acid suppression and gastric protection treatment at another hospital for half a year without improvement. His current symptoms included bloating, chest tightness, poor appetite, dry mouth, bitter taste in the mouth, and no drinking. His stools were sometimes dry and sometimes loose, with incomplete bowel movements. His tongue was pale red with a slightly greasy white tongue coating, and his pulse was stringy and rapid. Gastroscopy on May 25, 2021 (Hunan Provincial People's Hospital): atrophic gastritis with intestinal metaplasia (C3). Pathological examination (antral mucosa): moderate chronic inflammation of the mucosa, activity (-), intestinal metaplasia (+++), atrophy (+++), and Hp (-). The prescription is based on strengthening the spleen and regulating qi, clearing heat and dampness, and detoxifying and dispersing nodules. The prescription is modified from Jianpi Xiaowei Decoction: Codonopsis pilosula 15g, Atractylodes macrocephala 15g, Poria 15g, Pinellia ternata 9g, Chinese yam 15g, Magnolia officinalis 10g, Patrinia 12g, Taraxacum mongolicum 30g, Amomum villosum 6g (added last), Aucklandia lappa 10g, Licorice root 6g, Coix seed 15g, Tangerine peel 10g, Coptis chinensis 5g, Scutellaria baicalensis 10g, Cannabis sativa seed 15g, Citrus aurantium 10g, Cyperus rotundus 10g, Curcuma aromatica 12g, Citrus aurantium 5g, Panax notoginseng 5g, and Pollen charcoal 10g. 7 packets, decocted in water, one dose daily, divided into two doses. Second visit: November 19, 2021. Previous symptoms have improved. Last week, there was one episode of stomach pain, every two days, with difficulty defecating, dry mouth, bitter taste, toothache, and a tightness in the head. The tongue is pale red with ecchymosis, a thin white fur, and a wiry pulse. Add 7g of Schizonepeta and 10g of Saposhnikovia to the previous prescription, 7 packets, and continue. Third visit: November 25, 2021. Stomach pain, toothache, and headache have been relieved, chest tightness, clear watery mouth, dry mouth, bitter taste, undigested stool, difficulty in passing, first formed and then loose. The tongue is pale red, with a thin white coating, and a thready pulse. Prescription: Codonopsis pilosula 15g, Atractylodes macrocephala 15g, Poria cocos 15g, Pinellia ternata 9g, Chinese Yam 15g, Magnolia officinalis 10g, Patrinia 12g, Taraxacum mongolicum 30g, Amomum villosum 6g (added last), Costus root 10g, Licorice root 6g, Coix seed 15g, Tangerine peel 10g, Coptis chinensis 5g, Scutellaria baicalensis 10g, Cannabis sativa seed 15g, Citrus aurantium 10g, Cyperus rotundus 10g, Curcuma aromatica 12g, Citrus aurantium 5g, Panax notoginseng 5g, Pollen charcoal 10g, Dried ginger 5g, 15 packets, decocted in water, once daily, divided into two doses. Fourth visit, December 15, 2022: previous symptoms improved, with chest tightness, vomiting of clear water, dry and bitter mouth, pale red tongue, thin white greasy coating, and deep, thready pulse. Change the previous dried ginger to 10g, Atractylodes lancea 10g, and Patchouli 10g, 15 packets. After two months of symptomatic treatment, all symptoms were relieved. Gastroscopy at Xiangya Hospital, Central South University, March 3, 2022: The nature of the gastric mucosal lesion is yet to be determined, chronic non-atrophic gastritis (superficial) and antral gastritis. Pathology: moderate chronic superficial inflammation of the gastric mucosa with intestinal metaplasia. HP (0), active (-), chronic inflammation: (++), intestinal metaplasia (+).

[0080] Typical Case 2

[0081] Mr. Xie, a 30-year-old male, medical record number 18419149, first visited the hospital on May 3, 2022, for two years of left upper abdominal pain. He began experiencing dull pain in the left upper abdomen two years ago, which occurred after eating. He also had bloating, no acid reflux or heartburn, a good appetite, fatigue, no dryness or bitter taste in the mouth, regular bowel movements, and restful sleep. His tongue was pale red, with a thin white coating and a wiry pulse. A gastroscopy at Shenzhen Longhua District Central Hospital on April 15, 2022, revealed rough antral mucosa and chronic gastritis. A pathological examination revealed mild chronic inflammation of the antral mucosa, intestinal metaplasia (++), and atrophy (++). Jianpi Xiaowei Decoction with modifications: Astragalus 15g, Ginseng 10g, Atractylodes 15g, Poria 15g, Tangerine Peel 10g, Pinellia 9g, Amomum 6g, Chinese Yam 15g, Magnolia Officinalis 10g, Patrinia 12g, Taraxacum 12g, Amomum 6g (added last), Costus 10g, Licorice 6g, Jianqu 10g, Coix Seed 15g, Tangerine Peel 10g, Cyperus 10g, Curcuma 12g, Panax Notoginseng 5g, Puhuang Charcoal 10g. 15 packets, decocted in water, one dose daily, taken in two divided doses. Second visit on May 18, 2022: previous symptoms improved, and the original prescription with modifications was continued for 12 months. A follow-up gastroscopy was performed on April 28, 2023, at Shenzhen Longhua District Central Hospital: chronic non-atrophic gastritis.

[0082] Typical Case 3

[0083] Ms. Li, a 46-year-old female, first visited the hospital on July 10, 2021, after a physical examination revealed atrophic gastritis. Her current symptoms included: bloating with increased appetite, no acid reflux or heartburn, good appetite, fatigue, no dryness or bitter taste in the mouth, regular bowel movements, and restful sleep. Her tongue was pale red with a thin white coating and a wiry pulse. A gastroscopy performed on July 5, 2021, at the Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine revealed a diagnosis of chronic atrophic gastritis C2. I was given modified Jianpi Xiaowei Decoction: 15g of Astragalus, 10g of Ginseng, 15g of Atractylodes, 15g of Poria, 10g of Tangerine Peel, 9g of Pinellia, 6g of Amomum, 15g of Chinese Yam, 10g of Magnolia Officinalis, 12g of Patrinia Herba, 12g of Taraxacum, 6g of Amomum (added last), 10g of Costus Root, 6g of Licorice Root, 10g of Jianqu, 15g of Coix Seed, 10g of Tangerine Peel, 10g of Cyperus, 12g of Curcuma, 5g of Panax Notoginseng, 7g of Trillium, 7g of Curcuma, 10g of Puhuang Charcoal, 15g of Malt, 15g of Crataegus, 10g of Atractylodes, and 10g of Patchouli. 30 packets, decocted in water, one dose per day, taken in two divided doses. On the second visit on August 18, 2022, the previous symptoms had improved, and I continued with the original prescription for 30 packets. A follow-up gastroscopy on June 10, 2022, showed chronic non-atrophic gastritis.

[0084] The above are only embodiments of the present invention, and common knowledge such as the specific structure and / or characteristics of the scheme are not described in detail here. It should be pointed out that for those skilled in the art, without departing from the structure of the present invention, several variations and improvements can be made, which should also be regarded as the scope of protection of the present invention, and these will not affect the effect of the implementation of the present invention and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. A Chinese medicine composition for treating atrophic gastritis, characterized in that: The invention comprises the following raw materials: 15-50 parts of astragalus, 10-30 parts of ginseng, 15-50 parts of atractylodes, 10-50 parts of tuckahoe, 10-50 parts of yam, 10-60 parts of coix seeds, 6-30 parts of pinellia, 6-30 parts of tangerine peel, 10-30 parts of atractylodes, 7-30 parts of patchouli, 6-30 parts of safflower, 6-30 parts of curcuma, 3-10 parts of notoginseng, 10-30 parts of patrinia herb, 10-30 parts of dandelion, 10-30 parts of malt, 10-30 parts of jianqu, 10-30 parts of hawthorn, 5-15 parts of amomum, 6-30 parts of costusroot, 5-30 parts of roasted liquorice and 10-30 parts of curcuma.

2. A Chinese medicine composition for treating atrophic gastritis according to claim 1, characterized in that: It also includes 10-30 parts of Bupleurum and 15-45 parts of White Peony Root.

3. A Chinese medicine composition for treating atrophic gastritis according to claim 1, characterized in that: The invention also comprises 15-50 parts of corrugated paper, 30-60 parts of cuttlebone and 10-30 parts of Zhejiang Fritillary.

4. A Chinese medicine composition for treating atrophic gastritis according to claim 1, characterized in that: It also includes 3-10 parts of Coptis chinensis and 10-30 parts of Scutellaria baicalensis.

5. A Chinese medicine composition for treating atrophic gastritis according to claim 1, characterized in that: Also includes 4-30 portions of dried ginger.

6. A Chinese medicine composition for treating atrophic gastritis according to claim 1, characterized in that: It also includes 3-15 parts of Citrus aurantium and 10-30 parts of Magnolia officinalis.

7. Using the Chinese medicinal composition for treating atrophic gastritis according to any one of claims 1 to 6 for preparing a medicament for atrophic gastritis.

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