Method and system for detecting poliomyelitis vaccine rotary plunger pump filling hanging liquid

Abstract

The invention discloses a method and a system for detecting poliomyelitis vaccine rotary plunger pump filling hanging liquid, and relates to the technical field of poliomyelitis vaccine detection.The system comprises a model building end, a simulation tracking end and a hanging liquid correction end, the model building end is used for building a filling model, and the simulation tracking end is used for simulating the hanging liquid correction end; a mixed solution of an M199 solution and 2-phenoxyethanol is adopted to simulate a spine gray vaccine stock solution, the simulation tracking end is used for tracking up-down movement and rotary movement of a plunger pump in real time and tracking relative movement between a needle and a pre-filling injector in real time, and the hanging liquid correction end is used for correcting whether the optimal point is abnormal or not by judging the optimal point is abnormal or not. And the optimal correction point of the filling hanging liquid of the plunger pump is obtained. According to the method and system for detecting poliomyelitis vaccine rotary plunger pump filling hanging liquid, the hanging liquid problem of the rotary plunger pump during poliomyelitis vaccine subpackaging is optimally solved, whether the angle of the detected optimal point is abnormal or not is judged in real time, and the safety and reliability of poliomyelitis vaccine rotary plunger pump filling hanging liquid are guaranteed.

Description

Technical Field

[0001] The invention relates to the technical field of poliomyelitis vaccine detection, in particular to a method and a system for detecting poliomyelitis vaccine by using a rotary plunger pump to fill and hang liquid. Background Art

[0002] The large-stroke movement of the plunger pump simulates the vaccine filling process, mainly through the reciprocating motion of the plunger in the cylinder to achieve the suction and discharge of the medicine solution, thereby completing the precise filling of the vaccine. The plunger pump moves outward, the pressure in the working chamber decreases, and the rotation of the pump rod triggers the opening of the inlet valve and the closing of the outlet valve, and the medicine solution is sucked into the chamber. When the plunger pump is pushed inward, the pressure in the working chamber increases, and the pump rod rotates, the outlet valve opens, the inlet valve closes, and the medicine solution is discharged and enters the filling container.

[0003] At present, we have chosen a rotary plunger pump for filling for the polio vaccine filling line. However, from 2019 to 2022, the phenomenon of liquid hanging on the rubber stopper of the pre-filled syringe frequently occurred, resulting in a higher probability of liquid hanging when filling the polio vaccine, which reduced the yield rate of the product and weakened the safety of the vaccine to a certain extent.

[0004] Therefore, a method and system for detecting poliomyelitis vaccine rotary plunger pump filling suspension is proposed to solve the above problems. Summary of the invention

[0005] The main purpose of the present invention is to provide a method and system for detecting poliomyelitis vaccine rotary plunger pump filling suspension to solve the problems raised in the above background.

[0006] To achieve the above-mentioned purpose, the technical solution adopted by the present invention is: a method and system for detecting the filling and hanging liquid of a poliomyelitis vaccine rotary plunger pump, including a model building end, a simulation tracking end and a hanging liquid correction end;

[0007] The model building end is used to build a filling model, and use a mixture of M199 solution and 2-phenoxyethanol to simulate the polio vaccine stock solution, use the large stroke movement of the plunger pump to simulate the vaccine filling process, and repeatedly perform superposition training to reproduce the phenomenon of liquid hanging, so as to obtain a polio vaccine rotary plunger pump filling and liquid hanging model;

[0008] The simulation tracking end is used to timely determine whether the vaccine stock solution training simulation detected at the current moment is abnormal by real-time tracking of the up-and-down movement and rotational movement of the plunger pump and the relative movement between the needle and the prefilled syringe;

[0009] The liquid hanging correction end is used to determine the abnormality of the best point, and to detect and analyze the liquid hanging problem in real time, to obtain the best correction point for the plunger pump to fill the liquid hanging, and to automatically correct the up and down movement and rotational movement angle of the plunger pump and the parameters of the filling needle coordinated pump movement corresponding to the best correction point according to the best correction point, to ensure the accuracy of polio vaccine detection.

[0010] The model building end includes a filling model module, a hybrid simulation module and a motion setting module;

[0011] The filling model module includes a model building unit and a polio vaccine liquid unit;

[0012] The model building unit is used to build a rotary plunger pump filling model and set basic parameters of the rotary plunger pump filling, the basic parameters including rotation angle, optimal detection point and rotation duration;

[0013] The polio vaccine liquid unit is used to mix the M199 solution with 2-phenoxyethanol to obtain a simulated polio vaccine stock solution.

[0014] The mixing simulation module includes a liquid mixing unit and a parameter setting unit;

[0015] The mixing and homogenizing unit is used to drive the rotating magnetic field through the magnetic stirrer to make the stirrer rotate at high speed in the vaccine liquid to obtain a uniformly mixed polio vaccine stock solution;

[0016] The parameter setting unit is used to set the standard parameters for optimal detection of polio vaccine rotary plunger pump filling and hanging liquid, the parameters including the sealing parameters of the plunger pump, the output flow parameters of the plunger pump, the output pressure parameters of the plunger pump, the coordinated parameters of the plunger pump movement and the needle movement, the rotation angle of the plunger pump, the optimal detection point of the plunger pump and the rotation time of the plunger pump.

[0017] The movement setting module includes a vaccine dispensing unit and a dispensing tracking unit;

[0018] The vaccine sub-packaging unit is used to sub-pack the simulated polio vaccine stock solution into different volumes, and perform filling and hanging liquid testing on the simulated polio vaccine stock solutions of different volumes;

[0019] The packaging tracking unit is used to track the detection results of vaccine stock solution filling and hanging liquid in real time through a data tracker.

[0020] The simulation tracking terminal includes a motion monitoring module, a needle motion module and a simulation judgment module;

[0021] The motion monitoring module includes an up-and-down monitoring unit and a rotation monitoring unit;

[0022] The upper and lower monitoring units are used to capture the best detection point of the simulated polio vaccine stock solution filling and hanging liquid in real time through the camera, generate a picture from the image captured by the camera, compare the detection point in the picture with the best detection point in real time, and determine whether the best detection point is abnormal, specifically:

[0023] Compare the optimal test points for filling and hanging of simulated polio vaccine stock solution with the test points in the picture. The comparison formula is as follows:

[0024]

[0025] Among them, P n represents the comparison value, U1 represents the best detection point position of simulating polio vaccine stock solution filling and hanging liquid at the corresponding moment, U2 represents the detection point position in the picture at the corresponding moment, x represents the detection power consumption of the detection point in the tracked picture, and X represents the detection power consumption of the best detection point position of simulating polio vaccine stock solution filling and hanging liquid at the corresponding moment;

[0026] Step II: If the calculated P n If P is equal to 0, it is determined that the position of the tracked detection point is executed normally. n If it is not equal to 0, it is determined that the position of the tracked detection point is abnormal;

[0027] The rotation monitoring unit is used to monitor the rotation angle and rotation duration of the plunger pump in real time through a camera, and calculate in real time whether the rotation angle of the plunger pump deviates. The calculation method is as follows:

[0028] Set the rotation center point of the plunger pump as the origin, establish a coordinate system, and use the calculation formula to obtain the rotation angle vector of the plunger pump:

[0029]

[0030] Among them, α is the angle between the rotation distance of the plunger pump and the positive direction of the X-axis, θ is the angle between the rotation distance of the plunger pump and the positive direction of the Y-axis, A is the height of the plunger pump, Δx is the rotation angle vector of the plunger pump when it rotates in the X-axis direction, and Δy is the rotation angle vector of the plunger pump when it rotates in the Y-axis direction;

[0031] The calculated rotation angle vectors Δx and Δy of the plunger pump are subjected to difference calculation with the standard rotation angle of the plunger pump, and the standard difference values ​​are set to O and M. If Δx-O ≥ 1 or Δy-M ≥ 1, it is judged that the rotation angle of the plunger pump is abnormal; if not, it is judged that the rotation angle of the plunger pump is normal.

[0032] The needle motion module includes a relative motion unit, an optimal parameter unit and a difference calculation unit;

[0033] The relative motion unit is used to calculate the deviation vector of the rotation angle of the plunger pump at the current moment and the rotation angle of the plunger pump at the historical moment by using a formula to calculate whether the rotation angle of the plunger pump is deviated. If the calculated rotation direction vector is a positive number, it indicates that the rotation direction of the plunger pump is normal. If the calculated rotation direction vector is a negative number or 0, it indicates that the rotation direction of the plunger pump is abnormal, and the reporting system issues a voice reminder.

[0034] The optimal parameter unit is used to set the optimal parameter value of the relative motion between the needle and the prefilled syringe;

[0035] The difference calculation unit is used to calculate the deviation value of the relative movement between the needle and the prefilled syringe three times by using a formula to calculate whether the rotation angle of the plunger pump is deviated.

[0036] The simulation judgment module includes a simulation warning unit, which is used to indicate that the rotation angle deviation value of the plunger pump is normal when it is equal to 0, and indicate that it is abnormal when the rotation angle deviation value of the plunger pump is not equal to 0, and to issue a voice alarm to the reporting system.

[0037] The liquid hanging correction end includes a data receiving module, a liquid hanging detection module, a difference correction module and a correction monitoring module;

[0038] The data receiving module is used to receive the filling and hanging results of the simulated polio vaccine stock solution in real time through a data receiver;

[0039] The liquid hanging detection module is used for real-time analysis and detection of optimal parameters for poliomyelitis vaccine rotary plunger pump filling according to the filling liquid hanging results;

[0040] The difference correction module is used to correct the rotation angle and detection point of the plunger pump in real time according to the calculated rotation angle vector, and the correction value is determined according to the calculated value.

[0041] The correction monitoring module includes a correction self-tracking unit and a liquid hanging tracking and recording unit;

[0042] The correction self-tracking unit is used to receive the rotation angle vector of the rotational motion angle in real time through the data tracker, and receive the rotation angle vector after the correction value, and perform difference calculation on the front and back rotation angle vectors. If the difference is equal to 0, it means that the plunger pump rotation correction is invalid, and the reporting system recalculates and corrects it. If the difference is not equal to 0, it means that the plunger pump rotation correction is valid;

[0043] The liquid hanging tracking and recording unit is used to record the rotary plunger pump filling and liquid hanging parameters obtained by repeated simulation in real time through a data tracker, and calculate the average value of the parameters to obtain the best optimization parameters for detecting poliomyelitis vaccine rotary plunger pump filling and liquid hanging.

[0044] A method for detecting poliomyelitis vaccine rotary plunger pump filling suspension, comprising the following steps:

[0045] Step 1: Enter the model building end, build a filling model, use M199 solution and 2-phenoxyethanol mixed solution to simulate the polio vaccine stock solution, and use the large stroke movement of the plunger pump to simulate the vaccine filling process, and reproduce the liquid hanging phenomenon through multiple superposition training;

[0046] Step 2: Enter the simulation tracking end and determine the simulation abnormality by real-time tracking of the up and down movement and rotational movement of the plunger pump, as well as the relative movement between the needle and the prefilled syringe;

[0047] Step 3: Enter the liquid hanging correction end, simulate the vaccine filling process through large-stroke movement, and according to the abnormality of the best point judged, promptly correct the up and down movement and rotation movement of the plunger pump corresponding to the best point to ensure the accuracy of polio vaccine detection.

[0048] The present invention has the following beneficial effects:

[0049] 1. In the present invention, by setting a model building end, when detecting the polio vaccine rotary plunger pump filling and hanging liquid, by building a filling model, and using the large stroke movement of the plunger pump to simulate the vaccine filling process, after multiple superposition training to reproduce the hanging liquid phenomenon, the problem of the rotary plunger pump hanging liquid when filling polio vaccine is optimized and solved, which helps to improve the product yield and enhance the safety of the vaccine to a certain extent.

[0050] 2. In the present invention, by setting a simulation tracking end, when detecting the filling and hanging liquid of the polio vaccine rotary plunger pump, by real-time tracking the relative movement between the needle and the prefilled syringe, it is determined whether the vaccine stock solution training simulation is abnormal, so that when detecting the filling of the polio vaccine rotary plunger pump, it is possible to judge in real time whether the angle of the best point of detection is abnormal, thereby further ensuring the stability and accuracy of the detection of the rotational movement of the polio vaccine.

[0051] 3. In the present invention, by setting a hanging liquid correction end, when detecting the polio vaccine rotary plunger pump filling and hanging liquid, the best point abnormality is judged, and the up and down movement and rotational movement of the plunger pump corresponding to the best point are corrected in time, thereby further increasing the accuracy of polio vaccine detection and ensuring the safety and reliability of polio vaccine rotary plunger pump filling and hanging liquid detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0052] Figure 1 A schematic diagram of the system architecture of a method for detecting poliomyelitis vaccine rotary plunger pump filling and hanging liquid and a system thereof according to the present invention;

[0053] Figure 2A schematic diagram of the structure of a method for detecting poliomyelitis vaccine rotary plunger pump filling and hanging liquid and a system thereof;

[0054] Figure 3 A schematic diagram of the structure of a method for detecting poliomyelitis vaccine rotary plunger pump filling and hanging liquid and a simulation tracking end of the system thereof;

[0055] Figure 4 The present invention is a method for detecting poliomyelitis vaccine by using a rotary plunger pump to fill and hang liquid, and a schematic diagram of the structure of the hanging liquid correction end of the system. DETAILED DESCRIPTION

[0056] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below in conjunction with specific implementation methods.

[0057] Embodiment 1

[0058] Please refer to Figure 1-2 As shown: A method and system for detecting the filling and hanging liquid of a poliomyelitis vaccine rotary plunger pump, including a model building end, a simulation tracking end and a hanging liquid correction end;

[0059] The model building end is used to construct a filling model, and use a mixture of M199 solution and 2-phenoxyethanol to simulate the polio vaccine stock solution, use the large stroke movement of the plunger pump to simulate the vaccine filling process, and repeatedly perform superposition training to reproduce the phenomenon of hanging liquid, so as to obtain a polio vaccine rotary plunger pump filling and hanging liquid model;

[0060] The simulation tracking end is used to timely determine whether the vaccine stock solution training simulation being tested at the current moment is abnormal by real-time tracking of the up-and-down movement and rotational movement of the plunger pump, as well as the relative movement between the needle and the prefilled syringe;

[0061] The hanging liquid correction end is used to determine the abnormality of the best point, and to detect and analyze the hanging liquid problem in real time, to obtain the best correction point for the plunger pump to fill the hanging liquid, and to automatically correct the up and down movement and rotational movement angle of the plunger pump and the parameters of the filling needle coordinated pump movement corresponding to the best correction point according to the best correction point, to ensure the accuracy of polio vaccine detection. The parameters of the filling needle coordinated pump movement here specifically refer to the height.

[0062] The model building end includes a filling model module, a hybrid simulation module, and a motion setting module;

[0063] The filling model module includes a model building unit and a polio vaccine liquid unit;

[0064] The model building unit is used to build a rotary piston pump filling model and set basic parameters of the rotary piston pump filling, including rotation angle, optimal detection point and rotation time;

[0065] The polio vaccine liquid unit is used to mix M199 solution with 2-phenoxyethanol to obtain a simulated polio vaccine stock solution. The mixed solution of M199 solution and 2-phenoxyethanol is used to simulate the polio vaccine stock solution. The large stroke movement of the plunger pump is used to simulate the vaccine filling process, and different filling volumes of the vaccine stock solution are set. After multiple overlay trainings, the liquid hanging phenomenon is reproduced.

[0066] The mixing simulation module includes a liquid mixing unit and a parameter setting unit;

[0067] The liquid mixing unit is used to drive the rotating magnetic field through the magnetic stirrer to make the stirrer rotate at high speed in the vaccine liquid to obtain a uniformly mixed polio vaccine stock solution;

[0068] The parameter setting unit is used to set the standard parameters for optimal detection of polio vaccine rotary plunger pump filling and hanging liquid. The parameters include the sealing parameters of the plunger pump, the output flow parameters of the plunger pump, the output pressure parameters of the plunger pump, the coordinated parameters of the plunger pump movement and the needle movement, the rotation angle of the plunger pump, the optimal detection point of the plunger pump and the rotation time of the plunger pump. The coordinated parameters of the plunger pump movement and the needle movement here specifically refer to the noise parameters of the plunger pump and the temperature rise parameters of the plunger pump.

[0069] The movement setting module includes a vaccine dispensing unit and a dispensing tracking unit;

[0070] The vaccine filling unit is used to fill the simulated polio vaccine stock solution into different volumes, and to perform filling and hanging tests on the simulated polio vaccine stock solutions of different volumes;

[0071] The filling tracking unit is used to track the test results of vaccine concentrate filling and hanging liquid in real time through the data tracker, optimize the solution to the hanging liquid problem of the rotary plunger pump when filling polio vaccine, help to improve the yield rate of the product, and at the same time enhance the safety of the vaccine to a certain extent.

[0072] Embodiment 2

[0073] Please refer to Figure 3 As shown: Based on the first embodiment, the simulation tracking end includes a motion monitoring module, a needle motion module and a simulation judgment module;

[0074] The motion monitoring module includes an up-down monitoring unit and a rotation monitoring unit;

[0075] The upper and lower monitoring units are used to capture the best detection point of the simulated polio vaccine stock solution filling and hanging liquid in real time through the camera, generate a picture from the image captured by the camera, compare the detection point in the picture with the best detection point in real time, and determine whether the best detection point is abnormal, specifically:

[0076] Compare the optimal test points for filling and hanging of simulated polio vaccine stock solution with the test points in the picture. The comparison formula is as follows:

[0077]

[0078] Among them, P n represents the comparison value, U1 represents the best detection point position of the simulated polio vaccine stock solution filling and hanging liquid at the corresponding moment, U2 represents the detection point position in the picture at the corresponding moment, x represents the detection power consumption of the detection point in the tracked picture, X represents the detection power consumption of the best detection point position of the simulated polio vaccine stock solution filling and hanging liquid at the corresponding moment, and the power consumption here represents the detection power consumption in the process of simulating the polio vaccine stock solution filling and hanging liquid;

[0079] Step II: If the calculated P n If P is equal to 0, it is determined that the position of the tracked detection point is executed normally. n If it is not equal to 0, it is determined that the position of the tracked detection point is abnormal;

[0080] The rotation monitoring unit is used to monitor the rotation angle and rotation duration of the plunger pump in real time through a camera, and calculate in real time whether the rotation angle of the plunger pump deviates. The calculation method is as follows:

[0081] Set the rotation center point of the plunger pump as the origin, establish a coordinate system, and use the calculation formula to obtain the rotation angle vector of the plunger pump:

[0082]

[0083] Among them, α is the angle between the rotation distance of the plunger pump and the positive direction of the X-axis, θ is the angle between the rotation distance of the plunger pump and the positive direction of the Y-axis, A is the height of the plunger pump, Δx is the rotation angle vector of the plunger pump when it rotates in the X-axis direction, and Δy is the rotation angle vector of the plunger pump when it rotates in the Y-axis direction;

[0084] The calculated plunger pump rotation angle vectors Δx and Δy are subtracted from the standard rotation angle of the plunger pump, and the standard deviation is set to O and M. If Δx-O ≥ 1 or Δy-M ≥ 1, the rotation angle of the plunger pump is judged to be abnormal. If not, the rotation angle of the plunger pump is judged to be normal. By real-time tracking of the up and down movement and rotational movement of the plunger pump, as well as real-time tracking of the relative movement between the needle and the prefilled syringe, it is determined whether the vaccine concentrate training simulation is abnormal.

[0085] The needle motion module includes a relative motion unit, an optimal parameter unit and a difference calculation unit;

[0086] The relative motion unit is used to calculate the deviation vector of the plunger pump rotation angle at the current moment and the plunger pump rotation angle at the historical moment by using the formula to calculate whether the plunger pump rotation angle is deviated, as follows:

[0087] Set the position of the plunger pump as the origin, establish a coordinate system, and use the calculation formula to obtain the rotation direction vector of the plunger pump:

[0088]

[0089] Among them, α is the angle between the distance in the rotation direction of the plunger pump and the positive direction of the X-axis, θ is the angle between the distance in the rotation direction of the plunger pump and the positive direction of the Y-axis, A is the height of the plunger pump, Δx is the rotation direction vector of the plunger pump when it rotates in the X-axis direction, and Δy is the rotation direction vector of the plunger pump when it rotates in the Y-axis direction; if the calculated Δx and Δy rotation direction vectors are positive numbers, it means that the rotation direction of the plunger pump is normal. If the calculated rotation direction vector is a negative number or 0, it means that the rotation direction of the plunger pump is abnormal, and the reporting system issues a voice reminder;

[0090] The optimal parameter unit is used to set the optimal parameter value of the relative movement between the needle and the prefilled syringe;

[0091] The difference calculation unit is used to calculate the deviation value of the relative movement between the needle and the prefilled syringe three times by using a formula to calculate whether the rotation angle of the plunger pump is deviated, as follows:

[0092] Set the center point of the needle and the prefilled syringe as the origin, establish a coordinate system, and calculate the relative motion vector between the needle and the prefilled syringe using the calculation formula:

[0093]

[0094] Wherein, α is the angle between the relative movement distance between the needle and the prefilled syringe and the positive direction of the X-axis, θ is the angle between the relative movement distance between the needle and the prefilled syringe and the positive direction of the Y-axis, A is the height between the needle and the prefilled syringe, Δx is the relative movement vector between the needle and the prefilled syringe in the X-axis direction, and Δy is the relative movement vector between the needle and the prefilled syringe in the Y-axis direction;

[0095] The calculated relative motion vectors Δx and Δy between the needle and the prefilled syringe are subtracted from the standard relative motion between the needle and the prefilled syringe, and the standard difference values ​​are set to O and M. If Δx-O≥1 or Δy-M≥1, it is determined that the relative motion between the needle and the prefilled syringe is abnormal; if not, it is determined that the relative motion between the needle and the prefilled syringe is normal.

[0096] The simulation judgment module includes a simulation early warning unit, which is used to indicate that when the rotation angle deviation value of the plunger pump is equal to 0, it is normal, and if the rotation angle deviation value of the plunger pump is not equal to 0, it is abnormal. The reporting system will issue a voice alarm, and can judge in real time whether there is an angle abnormality at the best point of detection, further ensuring the stability and accuracy of detecting the rotational motion of polio vaccine.

[0097] Embodiment 3

[0098] Please refer to Figure 4 As shown: Based on the first embodiment, the liquid hanging correction end includes a data receiving module, a liquid hanging detection module, a difference correction module and a correction monitoring module;

[0099] The data receiving module is used to receive the filling and hanging results of the simulated polio vaccine stock solution in real time through the data receiver;

[0100] The liquid hanging detection module is used to analyze and detect the optimal parameters of poliomyelitis vaccine rotary plunger pump filling in real time according to the filling liquid hanging results;

[0101] The difference correction module is used to correct the rotation angle and detection point of the plunger pump in real time according to the calculated rotation angle vector. The correction value is determined according to the calculated value. By judging the abnormality of the best point and detecting and analyzing the hanging liquid problem in real time, the best correction point of the plunger pump filling and hanging liquid is obtained to ensure the accuracy of the optimal parameter setting for the poliomyelitis vaccine rotary plunger pump filling and hanging liquid detection.

[0102] The correction monitoring module includes a correction self-tracking unit and a liquid hanging tracking and recording unit;

[0103] The correction self-tracking unit is used to receive the rotation angle vector of the rotation motion angle in real time through the data tracker, and receive the rotation angle vector after the correction value, and calculate the difference between the front and rear rotation angle vectors. If the difference is equal to 0, it means that the plunger pump rotation correction is invalid, and the reporting system recalculates and corrects it. If the difference is not equal to 0, it means that the plunger pump rotation correction is valid;

[0104] The liquid hanging tracking and recording unit is used to record the rotary plunger pump filling and liquid hanging parameters obtained through repeated simulations in real time through a data tracker, and calculate the average value of the parameters to obtain the best optimization parameters for detecting the polio vaccine rotary plunger pump filling and liquid hanging. By timely correcting the up and down movement and rotational movement of the plunger pump corresponding to the optimal point, the accuracy of polio vaccine detection is further increased, thereby ensuring the safety and reliability of polio vaccine rotary plunger pump filling and liquid hanging detection.

[0105] In the present invention, a method and system for detecting the hanging liquid during the filling of a polio vaccine rotary plunger pump and the system are provided. When the system is in operation, a filling model is first constructed, and the model is used to restore the hanging liquid problem. After optimizing the filling parameters, it is verified whether the optimization effect reaches the expected goal. Then, the model construction end is entered to construct a filling model, and a mixture of M199 solution and 2-phenoxyethanol is used to simulate the polio vaccine stock solution. The large stroke movement of the plunger pump is used to simulate the vaccine filling process. The hanging liquid phenomenon is reproduced through multiple superposition training. After multiple superposition training, the hanging liquid phenomenon is reproduced, and the hanging liquid problem of the rotary plunger pump when filling the polio vaccine is optimized and solved, which is helpful to improve the yield of the product and enhance the safety of the vaccine to a certain extent. Then, the simulation tracking end is entered to judge the simulation abnormality by real-time tracking of the up and down movement and rotational movement of the plunger pump and the relative movement between the needle and the prefilled syringe. The relative movement between the needle and the prefilled syringe is tracked to determine whether the vaccine stock solution training simulation is abnormal, so that when the polio vaccine rotary plunger pump is filled, it can be determined in real time whether the angle of the best point of detection is abnormal, further ensuring the stability and accuracy of the polio vaccine rotational movement; entering the hanging liquid correction end, the vaccine filling process is simulated through a large stroke movement, and according to the abnormality of the best point determined, the up and down movement and rotational movement of the plunger pump corresponding to the best point are corrected in time to ensure the accuracy of polio vaccine detection, through the abnormality of the best point determined, the real-time detection and analysis of the hanging liquid problem, the best correction point for the plunger pump filling the hanging liquid is obtained, and the up and down movement and rotational movement of the plunger pump corresponding to the best point are corrected in time, further increasing the accuracy of polio vaccine detection, ensuring the safety and reliability of the polio vaccine rotary plunger pump filling and hanging liquid detection, and further optimizing the parameters of the polio vaccine rotary plunger pump filling and hanging liquid detection.

[0106] A method for detecting poliomyelitis vaccine rotary plunger pump filling suspension, comprising the following steps:

[0107] Step 1: Enter the model building end, build a filling model, use M199 solution and 2-phenoxyethanol mixed solution to simulate the polio vaccine stock solution, and use the large stroke movement of the plunger pump to simulate the vaccine filling process, and reproduce the liquid hanging phenomenon through multiple superposition training;

[0108] Step 2: Enter the simulation tracking end and determine the simulation abnormality by real-time tracking of the up and down movement and rotational movement of the plunger pump, as well as the relative movement between the needle and the prefilled syringe;

[0109] Step 3: Enter the liquid hanging correction end, simulate the vaccine filling process through large-stroke movement, and according to the abnormality of the best point judged, promptly correct the up and down movement and rotation movement of the plunger pump corresponding to the best point to ensure the accuracy of polio vaccine detection.

[0110] The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments. The above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention to be protected. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A system for detecting poliomyelitis vaccine rotary plunger pump filling and hanging liquid, characterized in that: The system includes a model building end, a simulation tracking end and a liquid hanging correction end; The model building end is used to build a filling model, and use a mixture of M199 solution and 2-phenoxyethanol to simulate the polio vaccine stock solution, use the large stroke movement of the plunger pump to simulate the vaccine filling process, and repeatedly perform superposition training to reproduce the phenomenon of liquid hanging, so as to obtain a polio vaccine rotary plunger pump filling and liquid hanging model; The simulation tracking end is used to timely determine whether the vaccine stock solution training simulation detected at the current moment is abnormal by real-time tracking of the up-and-down movement and rotational movement of the plunger pump and the relative movement between the needle and the prefilled syringe; The liquid hanging correction end is used to determine the abnormality of the best point, and to detect and analyze the liquid hanging problem in real time, to obtain the best correction point for the plunger pump to fill the liquid hanging, and to automatically correct the up and down movement and rotational movement angle of the plunger pump and the parameters of the filling needle coordinated pump movement corresponding to the best correction point according to the best correction point, to ensure the accuracy of polio vaccine detection.

2. The system according to claim 1, characterized in that: The model building end includes a filling model module, a hybrid simulation module and a motion setting module; The filling model module includes a model building unit and a polio vaccine liquid unit; The model building unit is used to build a rotary plunger pump filling model and set basic parameters of the rotary plunger pump filling, the basic parameters including rotation angle, optimal detection point and rotation duration; The polio vaccine liquid unit is used to mix the M199 solution with 2-phenoxyethanol to obtain a simulated polio vaccine stock solution.

3. The system according to claim 2, characterized in that: The mixing simulation module includes a liquid mixing unit and a parameter setting unit; The mixing and homogenizing unit is used to drive the rotating magnetic field through the magnetic stirrer to make the stirrer rotate at high speed in the vaccine liquid to obtain a uniformly mixed polio vaccine stock solution; The parameter setting unit is used to set the standard parameters for optimal detection of polio vaccine rotary plunger pump filling and hanging liquid, the parameters including the sealing parameters of the plunger pump, the output flow parameters of the plunger pump, the output pressure parameters of the plunger pump, the coordinated parameters of the plunger pump movement and the needle movement, the rotation angle of the plunger pump, the optimal detection point of the plunger pump and the rotation time of the plunger pump.

4. The system according to claim 3, characterized in that: The movement setting module includes a vaccine dispensing unit and a dispensing tracking unit; The vaccine sub-packaging unit is used to sub-pack the simulated polio vaccine stock solution into different volumes, and perform filling and hanging liquid testing on the simulated polio vaccine stock solutions of different volumes; The packaging tracking unit is used to track the detection results of vaccine stock solution filling and hanging liquid in real time through a data tracker.

5. The system according to claim 1, characterized in that: The simulation tracking terminal includes a motion monitoring module, a needle motion module and a simulation judgment module; The motion monitoring module includes an up-and-down monitoring unit and a rotation monitoring unit; The upper and lower monitoring units are used to capture the best detection point of the simulated polio vaccine stock solution filling and hanging liquid in real time through the camera, generate a picture from the image captured by the camera, compare the detection point in the picture with the best detection point in real time, and determine whether the best detection point is abnormal, specifically: Compare the optimal test points for filling and hanging of simulated polio vaccine stock solution with the test points in the picture. The comparison formula is as follows: Among them, P n represents the comparison value, U1 represents the best detection point position of simulating polio vaccine stock solution filling and hanging liquid at the corresponding moment, U2 represents the detection point position in the picture at the corresponding moment, x represents the detection power consumption of the detection point in the tracked picture, and X represents the detection power consumption of the best detection point position of simulating polio vaccine stock solution filling and hanging liquid at the corresponding moment; Step II: If the calculated P n If P is equal to 0, it is determined that the position of the tracked detection point is executed normally. n If it is not equal to 0, it is determined that the position of the tracked detection point is abnormal; The rotation monitoring unit is used to monitor the rotation angle and rotation duration of the plunger pump in real time through a camera, and calculate in real time whether the rotation angle of the plunger pump deviates. The calculation method is as follows: Set the rotation center point of the plunger pump as the origin, establish a coordinate system, and use the calculation formula to obtain the rotation angle vector of the plunger pump: Among them, α is the angle between the rotation distance of the plunger pump and the positive direction of the X-axis, θ is the angle between the rotation distance of the plunger pump and the positive direction of the Y-axis, A is the height of the plunger pump, Δx is the rotation angle vector of the plunger pump when it rotates in the X-axis direction, and Δy is the rotation angle vector of the plunger pump when it rotates in the Y-axis direction; The calculated rotation angle vectors Δx and Δy of the plunger pump are subjected to difference calculation with the standard rotation angle of the plunger pump, and the standard difference values ​​are set to O and M. If Δx-O ≥ 1 or Δy-M ≥ 1, it is judged that the rotation angle of the plunger pump is abnormal; if not, it is judged that the rotation angle of the plunger pump is normal.

6. The system according to claim 5, characterized in that: The needle motion module includes a relative motion unit, an optimal parameter unit and a difference calculation unit; The relative motion unit is used to calculate the deviation vector of the rotation angle of the plunger pump at the current moment and the rotation angle of the plunger pump at the historical moment by a formula for calculating whether the rotation angle of the plunger pump is deviated. If the calculated rotation direction vector is a positive number, it indicates that the rotation direction of the plunger pump is normal. If the calculated rotation direction vector is a negative number or 0, it indicates that the rotation direction of the plunger pump is abnormal, and the reporting system issues a voice reminder. The optimal parameter unit is used to set the optimal parameter value of the relative motion between the needle and the prefilled syringe; The difference calculation unit is used to calculate the deviation value of the relative movement between the needle and the prefilled syringe three times by using a formula to calculate whether the rotation angle of the plunger pump is deviated.

7. The system according to claim 6, characterized in that: The simulation judgment module includes a simulation warning unit, which is used to indicate that the rotation angle deviation value of the plunger pump is normal when it is equal to 0, and indicate that it is abnormal when the rotation angle deviation value of the plunger pump is not equal to 0, and to issue a voice alarm to the reporting system.

8. The system according to claim 1, characterized in that: The liquid hanging correction end includes a data receiving module, a liquid hanging detection module, a difference correction module and a correction monitoring module; The data receiving module is used to receive the filling and hanging results of the simulated polio vaccine stock solution in real time through a data receiver; The liquid hanging detection module is used for real-time analysis and detection of optimal parameters for poliomyelitis vaccine rotary plunger pump filling according to the filling liquid hanging results; The difference correction module is used to correct the rotation angle and detection point of the plunger pump in real time according to the calculated rotation angle vector, and the correction value is determined according to the calculated value.

9. The system according to claim 8, characterized in that: The correction monitoring module includes a correction self-tracking unit and a liquid hanging tracking and recording unit; The correction self-tracking unit is used to receive the rotation angle vector of the rotational motion angle in real time through the data tracker, and receive the rotation angle vector after the correction value, and perform difference calculation on the front and back rotation angle vectors. If the difference is equal to 0, it means that the plunger pump rotation correction is invalid, and the reporting system recalculates and corrects it. If the difference is not equal to 0, it means that the plunger pump rotation correction is valid; The liquid hanging tracking and recording unit is used to record the rotary plunger pump filling and liquid hanging parameters obtained by repeated simulation in real time through a data tracker, and calculate the average value of the parameters to obtain the best optimization parameters for detecting poliomyelitis vaccine rotary plunger pump filling and liquid hanging.

10. A method for detecting polio vaccine rotary plunger pump filling and hanging liquid, according to a system for detecting polio vaccine rotary plunger pump filling and hanging liquid according to any one of claims 1-9, characterized in that: The following steps are involved: Step 1: Enter the model building end, build a filling model, use M199 solution and 2-phenoxyethanol mixed solution to simulate the polio vaccine stock solution, and use the large stroke movement of the plunger pump to simulate the vaccine filling process, and reproduce the liquid hanging phenomenon through multiple superposition training; Step 2: Enter the simulation tracking end and determine the simulation abnormality by real-time tracking of the up and down movement and rotational movement of the plunger pump, as well as the relative movement between the needle and the prefilled syringe; Step 3: Enter the liquid hanging correction end, simulate the vaccine filling process through large-stroke movement, and according to the abnormality of the best point judged, promptly correct the up and down movement and rotation movement of the plunger pump corresponding to the best point to ensure the accuracy of polio vaccine detection.

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