One-piece infusion dressing

Abstract

The invention discloses a one-piece infusion dressing which comprises an adhesive tape layer, a chip layer and a protective film layer. The adhesive tape layer, the chip layer and the protective film layer are sequentially attached from top to bottom; the chip layer is a nano-silver biological protein fiber cloth layer, and nano-silver particles are uniformly distributed in the nano-silver biological protein fiber cloth layer and on the surface of the nano-silver biological protein fiber cloth layer. According to the one-piece infusion dressing, the technical problem that nano-silver particles of an existing one-piece infusion dressing are prone to falling off can be solved.

Description

Technical Field

[0001] The present invention relates to the technical field of medical infusion patch, in particular to a one-piece infusion dressing. Background Art

[0002] There are various infusion dressings on the market. Among them, most infusion dressings only have a simple dressing function, and do not have the functions of preventing infection, inhibiting bacteria and reducing inflammation. Although there are a few infusion dressings with antibacterial and anti-inflammatory functions, most of them are achieved by coating a variety of traditional Chinese medicines, with a complicated preparation process and limited antibacterial effect. In addition, most of the current infusion dressings have three tapes, which are troublesome to use, and non-woven fabrics are used as the carrier of the tape, which is uncomfortable to apply, unsightly, not firm, and easy to fall off. It can be seen that the infusion dressings in the prior art have multiple defects and need to be further improved.

[0003] Patent CN221771099U discloses a one-piece infusion dressing, which includes a tape layer, a chip layer and a protective film layer, wherein the chip layer is coated with a nanosilver particle layer, which has the effect of antibacterial and anti-inflammatory, and effectively solves the defects of the above-mentioned infusion dressing. However, this one-piece infusion dressing still has the following problems: the chip layer of the infusion dressing is a nanosilver particle layer coated on an alginate fiber cloth; although the nanosilver particles coated on the chip layer can play a certain antibacterial and anti-inflammatory effect, the nanosilver particles are not firmly combined with the alginate fiber cloth, and when they come into contact with the infusion needle eye, there is a risk of entering the human body through the needle eye (nanosilver can cross multiple biological barriers, causing clear central nervous system toxicity, reproductive system toxicity and genetic toxicity), and the nanosilver particle layer has a certain impact on the moisture absorption and hemostasis of the alginate fiber cloth layer. Therefore, it is necessary to further improve the one-piece infusion dressing. Summary of the invention

[0004] Therefore, the technical problem to be solved by the present invention is to provide a one-piece infusion dressing to solve the technical problem that the nano-silver particles of the existing one-piece infusion dressing are easy to fall off.

[0005] In order to solve the above technical problems, the present invention provides the following technical solutions:

[0006] A one-piece infusion dressing comprises a tape layer, a chip layer and a protective film layer; the tape layer, the chip layer and the protective film layer are laminated in sequence from top to bottom; the chip layer is a nano-silver bio-protein fiber cloth layer, and nano-silver particles are evenly distributed inside and on the surface of the nano-silver bio-protein fiber cloth layer (the infusion dressing can prevent bacteria from invading and causing cross infection, and avoid the risk of nano-silver particles entering the human body through a needle hole due to loose binding).

[0007] The method for preparing the chip layer of the one-piece infusion dressing comprises the following steps:

[0008] Step (1), preparing the biological protein into a spinning solution;

[0009] Step (2), preparing nano silver particles;

[0010] Step (3), adding nano silver particles into the spinning solution and mixing and stirring to obtain the nano silver spinning solution;

[0011] Step (4), electrospinning the nano-silver spinning solution using electrospinning technology to obtain a nano-silver bioprotein fiber cloth;

[0012] Step (5), cutting the nano silver bioprotein fiber cloth to obtain a chip layer.

[0013] In the above one-piece infusion dressing, in step (1), the biological protein is one or a mixture of two or more of soybean protein, silk protein, shrimp shell protein or crab shell protein.

[0014] In the above one-piece infusion dressing, in step (2), the preparation method of the nano silver particles is:

[0015] Step (2-1), adding silver nitrate to N,N,N′,N′-tetramethylethylenediamine (TMEDA) and heating and stirring to fully react to obtain a mixed reaction system;

[0016] Step (2-2), adding anhydrous ethanol to the mixed reaction system to carry out a precipitation reaction, and after the reaction is completed, separating the solid and the liquid to obtain a precipitate;

[0017] Step (2-3), washing the precipitate with anhydrous ethanol and then vacuum drying to obtain nano silver particles.

[0018] In the above-mentioned one-piece infusion dressing, in step (2-1), the mass volume ratio of silver nitrate to N,N,N′,N′-tetramethylethylenediamine is 0.5-1.2 g / mL; the temperature of the heating reaction is 150-200° C., and the reaction time is 0.5-1 h; in step (2-2), the volume ratio of anhydrous ethanol to the mixed reaction system is 1:1.5-2; in step (2-3), the vacuum drying temperature is 30-40° C., and the vacuum drying time is 5-8 h. The nanosilver particles prepared under the above-mentioned reaction conditions are basically standard spherical, with a particle size range of 3-20 nm, have good antibacterial effect, and can be evenly dispersed in the spinning solution, which is conducive to the smooth progress of the subsequent silk making process and provides favorable conditions for subsequent uniform dispersion inside and on the surface of the bioprotein fiber cloth. In addition, the experiment found that compared with commercially available nanosilver particles, the nanosilver particles with a particle size range of 3 to 20 nm prepared by this method are more easily dispersed evenly on the bio-protein fiber cloth in the form of "one end inserted into the interior of the bio-protein fiber and the other end exposed on the surface of the bio-protein fiber" when spun into bio-protein fibers. This combination form is more conducive to the antibacterial effect of nanosilver particles and is not easy to fall off from the bio-protein fiber cloth.

[0019] In the above-mentioned one-piece infusion dressing, in step (2-1), the mass volume ratio of silver nitrate to N,N,N′,N′-tetramethylethylenediamine is 1.0 g / mL; the temperature of the heating reaction is 200° C., and the reaction time is 0.5 h; in step (2-2), the volume ratio of anhydrous ethanol to the mixed reaction system is 1:1.5; in step (2-3), the temperature of vacuum drying is 40° C., and the vacuum drying time is 5 h.

[0020] In the above one-piece infusion dressing, in step (3), the amount of nanosilver particles added to the nanosilver spinning solution is such that the weight percentage content of the nanosilver particles in the nanosilver bioprotein fiber cloth in step (4) is 150 to 250 ppm.

[0021] The above-mentioned one-piece infusion dressing has breathable and waterproof micropores on the tape layer. The size of the micropores is 100-500nm. Such micropores can allow skin moisture to be discharged smoothly and prevent external moisture from entering, thereby avoiding problems such as skin itching caused by poor breathing when the infusion time is too long.

[0022] The preparation method of the tape layer of the one-piece infusion dressing is as follows: coating a polymer medical oil gel on a carrier; the carrier is a medical 0.01 nanometer PU film, 0.1 cm artificial cotton cloth, silk cloth, ice silk cloth or spunlace non-woven fabric; the spraying thickness of the polymer medical oil gel is less than or equal to 0.1 nm; the polymer medical oil gel has unchanged viscosity in an environment of -40°C to 40°C, is firmly bonded, and is not easy to fall off; the protective film layer has a density of 30 to 50 g / m 2Medical polyurethane film or silicone oil paper (preferably 38g / m 2 Silicone oil paper); the material is transparent and easy to open when used.

[0023] In the above-mentioned one-piece infusion dressing, the area of ​​the chip layer is smaller than that of the tape layer, and the area of ​​the tape layer is the same as that of the protective film layer; the area of ​​the chip layer is 1.5*1.5cm, and the thickness of the chip layer is less than or equal to 0.3cm; the closest distance from the upper edge of the chip layer to the tape layer is 2.5cm, and the closest distance from the lower edge, left and right edges of the chip layer to the tape layer is 1.5cm (for the convenience of fixing the infusion tube); the tape layer and the protective film layer are provided with U-shaped infusion tube fixing ports that cooperate with each other, and the size of the U-shaped infusion tube fixing port is 0.5*1.0cm. The one-piece infusion dressing of the present invention is a four-sided self-adhesive one-piece infusion patch dressing, which can replace the old three-strip infusion patch, solves the shortcomings of its loose adhesion, non-sealed four sides, and easy invasion of bacteria from both sides, and is comfortable, beautiful, firm and does not fall off.

[0024] The one-piece infusion dressing of the present invention can be rectangular or oval, preferably rectangular or oval. When in use, the protective film layer is torn off and the dressing is then attached to the infusion site.

[0025] The technical solution of the present invention achieves the following beneficial technical effects:

[0026] 1. Compared with the prior art, the one-piece infusion dressing of the present invention has a chip layer which is a nano-silver bio-protein fiber cloth layer, and the nano-silver particles are distributed inside and on the surface of the nano-silver bio-protein fiber cloth layer of the chip layer. This distribution method not only ensures the effect of inhibiting bacteria and inflammation and preventing infection, but also avoids the risk of nano-silver particles entering the human body through the needle hole when contacting the infusion needle hole; in addition, compared with other materials, the bio-protein fiber not only has good biocompatibility, but also has a more significant moisture absorption and hemostasis effect.

[0027] 2. Compared with the method of preparing the nanosilver particle layer by immersing the alginate fiber cloth in a nanosilver particle solution in the background art, the preparation method of the chip layer of the present invention allows the nanosilver particles to be wrapped by the biological protein fiber during the silk making process, so that most of the nanosilver particles on the chip layer are fixed on the biological protein fiber, and the two are more firmly combined, thereby achieving the technical purpose of reducing the risk of the nanosilver particles entering the human body through the needle eye when contacting the infusion needle eye.

[0028] 3. Compared with commercially available nanosilver particles, the homemade nanosilver particles of the present invention not only have an ideal shape (basically a standard spherical structure) and a good antibacterial effect, but also have a uniform particle size, with a particle size range of 3-20nm, which is conducive to its uniform dispersion in the bioprotein spinning solution and embedding into the bioprotein fiber during the spinning process. DETAILED DESCRIPTION

[0029] The one-piece infusion dressing of this embodiment includes a tape layer, a chip layer and a protective film layer; the tape layer, the chip layer and the protective film layer are laminated in sequence from top to bottom; the chip layer is a nanosilver bioprotein fiber cloth layer, and the nanosilver particles are evenly distributed inside and on the surface of the nanosilver bioprotein fiber cloth layer.

[0030] The method for preparing the chip layer comprises the following steps:

[0031] Step (1), preparing the biological protein into a spinning solution; the biological protein used in this embodiment is soybean protein, and in some other embodiments it can also be one or a mixture of two or more of silk protein, shrimp shell protein or crab shell protein.

[0032] Step (2), preparing nano silver particles; the preparation method of nano silver particles is:

[0033] Step (2-1), adding silver nitrate to N,N,N′,N′-tetramethylethylenediamine (TMEDA), heating and stirring to fully react, to obtain a mixed reaction system; the mass volume ratio of silver nitrate to N,N,N′,N′-tetramethylethylenediamine is 1.0 g / mL; the heating reaction temperature is 200° C., and the reaction time is 0.5 h;

[0034] Step (2-2), adding anhydrous ethanol to the mixed reaction system to carry out a precipitation reaction, and after the reaction is completed, separating the solid and the liquid to obtain a precipitate; the volume ratio of the anhydrous ethanol to the mixed reaction system is 1:1.5;

[0035] Step (2-3), washing the precipitate with anhydrous ethanol and then vacuum drying to obtain nanosilver particles; the vacuum drying temperature is 40° C. and the vacuum drying time is 5 hours;

[0036] Step (3), adding nano silver particles into the spinning solution and mixing and stirring to obtain the nano silver spinning solution;

[0037] Step (4), electrospinning the nanosilver spinning solution using electrospinning technology to obtain a nanosilver bioprotein fiber cloth; in this embodiment, the amount of nanosilver particles added to the nanosilver spinning solution is controlled to obtain a nanosilver bioprotein fiber cloth having a weight percentage content of 150 ppm of nanosilver particles;

[0038] Step (5), cutting the nano-silver bio-protein fiber cloth to obtain a chip layer; the area of ​​the chip layer is 1.5*1.5 cm, and the thickness of the chip layer is equal to 0.3 cm.

[0039] In this embodiment, the preparation method of the tape layer is: coating a polymer medical oil glue on a carrier; the carrier is 0.1 cm artificial cotton cloth; the spraying thickness of the polymer medical oil glue is equal to 0.1 nm; the polymer medical oil glue has unchanged viscosity in an environment of -40°C to 40°C, is firmly bonded, and is not easy to fall off; the protective film layer has a density of 38g / m 2 (In some other embodiments, air-permeable and water-impermeable micropores may be provided on the tape layer, and the size of the micropores is 100-500 nm).

[0040] In this embodiment, the area of ​​the chip layer is smaller than that of the tape layer, and the area of ​​the tape layer is the same as that of the protective film layer; the closest distance from the upper edge of the chip layer to the tape layer is 2.5 cm, and the closest distances from the lower edge and left and right edges of the chip layer to the tape layer are both 1.5 cm; the tape layer and the protective film layer are provided with U-shaped infusion tube fixing ports that cooperate with each other, and the size of the U-shaped infusion tube fixing port is 0.5*1.0 cm.

[0041] The one-piece infusion dressing of this embodiment was used in clinical trials. No shedding of nanosilver particles occurred during use, and its antibacterial effect was better than that of the one-piece infusion dressing in the background technology.

[0042] Obviously, the above embodiments are merely examples for the purpose of clear explanation, and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived therefrom are still within the scope of protection of the claims of this patent application.

Claims

1. A one-piece infusion dressing, characterized in that: It comprises a tape layer, a chip layer and a protective film layer; the tape layer, the chip layer and the protective film layer are laminated in sequence from top to bottom; the chip layer is a nano-silver bio-protein fiber cloth layer, and the nano-silver particles are evenly distributed inside and on the surface of the nano-silver bio-protein fiber cloth layer.

2. The one-piece infusion dressing according to claim 1, characterized in that: The method for preparing the chip layer comprises the following steps: Step (1), preparing the biological protein into a spinning solution; Step (2), preparing nano silver particles; Step (3), adding nano silver particles into the spinning solution and mixing and stirring to obtain the nano silver spinning solution; Step (4), electrospinning the nano-silver spinning solution using electrospinning technology to obtain a nano-silver bioprotein fiber cloth; Step (5), cutting the nano silver bioprotein fiber cloth to obtain a chip layer.

3. The one-piece infusion dressing according to claim 2, characterized in that: In step (1), the biological protein is one or a mixture of two or more of soybean protein, silk protein, shrimp shell protein or crab shell protein.

4. The one-piece infusion dressing according to claim 2, characterized in that: In step (2), the preparation method of nano silver particles is: Step (2-1), adding silver nitrate to N,N,N′,N′-tetramethylethylenediamine and heating and stirring to fully react to obtain a mixed reaction system; Step (2-2), adding anhydrous ethanol to the mixed reaction system to carry out a precipitation reaction, and after the reaction is completed, separating the solid and the liquid to obtain a precipitate; Step (2-3), washing the precipitate with anhydrous ethanol and then vacuum drying to obtain nano silver particles.

5. The one-piece infusion dressing according to claim 4, characterized in that: In step (2-1), the mass volume ratio of silver nitrate to N,N,N′,N′-tetramethylethylenediamine is 0.5 to 1.2 g / mL; the heating reaction temperature is 150 to 200° C., and the reaction time is 0.5 to 1 h; In step (2-2), the volume ratio of anhydrous ethanol to the mixed reaction system is 1:1.5-2; In step (2-3), the vacuum drying temperature is 30 to 40° C., and the vacuum drying time is 5 to 8 hours.

6. The one-piece infusion dressing according to claim 5, characterized in that: In step (2-1), the mass volume ratio of silver nitrate to N,N,N′,N′-tetramethylethylenediamine is 1.0 g / mL; the heating reaction temperature is 200° C., and the reaction time is 0.5 h; In step (2-2), the volume ratio of anhydrous ethanol to the mixed reaction system is 1:1.5; In step (2-3), the vacuum drying temperature is 40° C. and the vacuum drying time is 5 h.

7. The one-piece infusion dressing according to claim 2, characterized in that: In step (3), the amount of nanosilver particles added to the nanosilver spinning solution is such that the weight percentage content of the nanosilver particles in the nanosilver bioprotein fiber cloth in step (4) is 150 to 250 ppm.

8. The one-piece infusion dressing according to any one of claims 1 to 7, characterized in that: The tape layer is provided with air-permeable and water-impermeable micropores, and the size of the micropores is 100-500nm.

9. The one-piece infusion dressing according to any one of claims 1 to 7, characterized in that: The preparation method of the tape layer is as follows: coating a polymer medical oil glue on a carrier; the carrier is a medical 0.01 nanometer PU film, 0.1 cm artificial cotton cloth, silk cloth, ice silk cloth or spunlace non-woven fabric; the spraying thickness of the polymer medical oil glue is less than or equal to 0.1 nm; the polymer medical oil glue has unchanged viscosity under an environment of -40°C to 40°C; the protective film layer has a density of 30 to 50 g / m 2 Medical polyurethane film or silicone oil paper.

10. The one-piece infusion dressing according to any one of claims 1 to 7, characterized in that: The area of ​​the chip layer is smaller than that of the tape layer, and the area of ​​the tape layer is the same as that of the protective film layer; the area of ​​the chip layer is 1.5*1.5cm, and the thickness of the chip layer is less than or equal to 0.3cm; the closest distance from the upper edge of the chip layer to the tape layer is 2.5cm, and the closest distance from the lower edge and left and right edges of the chip layer to the tape layer is 1.5cm; the tape layer and the protective film layer are provided with U-shaped infusion tube fixing ports that cooperate with each other, and the size of the U-shaped infusion tube fixing port is 0.5*1.0cm.