Permeation enhancing composition as well as preparation method and application thereof

Abstract

The invention discloses a permeation enhancing composition as well as a preparation method and application thereof, and belongs to the technical field of cosmetics, the permeation enhancing composition comprises the following components in parts by mass: 0.5-8 parts of hydrolyzed sodium hyaluronate, 5-20 parts of a stabilizer, 12-25 parts of saccharomycetes / rice fermentation product filtrate and 40-80 parts of a solvent; the stabilizer is prepared from decapeptide-4, soya bean lecithin, sodium carboxymethyl cellulose and a polyethylene glycol surfactant according to the mass ratio of (0.05 to 0.4) to (0.05 to 0.4) to (0.08 to 0.5) to 1. Under the combined action of the hydrolyzed sodium hyaluronate, the stabilizer and the saccharomycetes / rice fermentation product filtrate, the surface tension is effectively reduced, the permeability and wettability of liquid are improved, the permeability of cell membranes is destroyed, and the anti-oxidation effect and stability of the composition are improved, the skin barrier is repaired, and the moisturizing effect and skin elasticity of the composition are improved. On the basis of not destroying the skin barrier, effective components are promoted to permeate into the deep layer of the skin, the effective components are mildly released, and effective absorption of the skin is promoted.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a penetration-enhancing composition and a preparation method and application thereof. Background Art

[0002] As the largest organ in the human body, the skin has a strong barrier function that can block the invasion of harmful substances from the outside world, but it also hinders the skin's absorption of effective ingredients. In particular, for active ingredients such as polyphenols and non-steroidal anti-inflammatory drugs, their penetration rate is low due to the barrier function of the skin's stratum corneum.

[0003] Transdermal absorption of cosmetics refers to the process in which the effective or functional ingredients in cosmetics act on the skin surface or enter the epidermis, dermis and other skin layers, accumulate in this part and play an effective role. The barrier function of the skin makes many ingredients have poor transdermal permeability. It is difficult for the effective ingredients of cosmetics to penetrate the skin and reach the body and play their due role. Therefore, how to improve the transdermal permeability of these active ingredients is a technical problem that needs to be solved in the field of cosmetics and topical drug research and development.

[0004] In view of this, this application is filed. Summary of the invention

[0005] The purpose of the present invention is to overcome the shortcomings of the prior art and provide a penetration-enhancing composition and a preparation method and application thereof. The composition has an excellent penetration-enhancing effect and can effectively promote the penetration of active ingredients.

[0006] To achieve the above-mentioned object, the first aspect of the present application provides a penetration-enhancing composition, comprising the following components in parts by weight: 0.5 to 8 parts of hydrolyzed sodium hyaluronate, 5 to 20 parts of a stabilizer, 12 to 25 parts of a yeast / rice fermentation product filtrate, and 40 to 80 parts of a solvent;

[0007] The stabilizer comprises decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose and a polyethylene glycol surfactant in a mass ratio of (0.05-0.4):(0.05-0.4):(0.08-0.5):1.

[0008] As an embodiment of the present application, the following components are included in parts by mass: 2 to 6 parts of hydrolyzed sodium hyaluronate, 12 to 20 parts of stabilizer, 18 to 22 parts of yeast / rice fermentation product filtrate, and 56 to 64 parts of solvent.

[0009] As an embodiment of the present application, the polyethylene glycol surfactant includes at least one of PEG-4 dilaurate, PEG-40 hydrogenated castor oil, and PEG-60 hydrogenated castor oil.

[0010] As an embodiment of the present application, the solvent includes at least one of isononyl isononanoate, dimethyl isosorbide, and an alcohol solvent.

[0011] As an embodiment of the present application, the solvent includes isononyl isononanoate, dimethyl isosorbide and an alcohol solvent in a mass ratio of (0.1-0.4):(0.2-0.5):1.

[0012] As an embodiment of the present application, the alcohol solvent includes at least one of glycerol, 1,2-propylene glycol, 2,3-propylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, 1,2-pentanediol, and isoprene glycol.

[0013] As an embodiment of the present application, the stabilizer includes decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose, and a polyethylene glycol surfactant in a mass ratio of (0.08-0.2):(0.08-0.2):(0.1-0.3):1.

[0014] As an embodiment of the present application, the weight average molecular weight of the sodium carboxymethyl cellulose is 90,500 to 250,000, and the viscosity of a 2 wt % aqueous solution of the sodium carboxymethyl cellulose at 25° C. is 25 to 100 mPa.s.

[0015] As an embodiment of the present application, the weight average molecular weight of the hydrolyzed sodium hyaluronate is 3,000 to 10,000.

[0016] As an embodiment of the present application, the mass ratio of the sum of the mass of the hydrolyzed sodium hyaluronate and the yeast / rice fermentation product filtrate to the mass of the stabilizer is (1.1-2.5):1, preferably (1.625-2):1.

[0017] The second aspect of the present application provides a method for preparing a penetration-enhancing composition, comprising the following steps:

[0018] The hydrolyzed sodium hyaluronate, the stabilizer, the yeast / rice fermentation product filtrate and the solvent are uniformly mixed to obtain a penetration-enhancing composition.

[0019] The third aspect of the present application provides a use of a penetration-enhancing composition in the preparation of cosmetics.

[0020] As an embodiment of the present application, the dosage form of the cosmetic is an aqueous solution, emulsion, cream, gel, mask or essence.

[0021] As an embodiment of the present application, the mass percentage of the penetration-enhancing composition in the cosmetic is 0.001 to 20%.

[0022] The beneficial effect of the present invention is that: the present invention combines hydrolyzed sodium hyaluronate, a stabilizer, and a yeast / rice fermentation product filtrate according to the above-mentioned specific dosage. Under the joint action of hydrolyzed sodium hyaluronate, a stabilizer, and a yeast / rice fermentation product filtrate, the surface tension is effectively reduced, the permeability and wettability of the liquid are improved, and the permeability of the cell membrane is destroyed. On the basis of not destroying the skin barrier, the effective ingredients are promoted to penetrate into the deep layer of the skin, the effective ingredients are gently released, and the skin is effectively absorbed. Based on the complex action mechanism of hydrolyzed sodium hyaluronate, a stabilizer, and a yeast / rice fermentation product filtrate on the skin, the selection and ratio of the three ingredients also have a high specific matching. If the types in the composition are replaced or the dosages of the three are changed, the penetration-promoting effect will be significantly reduced. DETAILED DESCRIPTION

[0023] In order to make the purpose, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application are described clearly and completely below. Obviously, the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present application.

[0024] In the present application, the technical features described in an open manner include closed technical solutions composed of the listed features, and also include open technical solutions containing the listed features.

[0025] In this application, when it comes to numerical ranges, unless otherwise specified, the above numerical ranges are deemed to be continuous and include the minimum and maximum values ​​of the range, as well as each value between such minimum and maximum values. Further, when a range refers to an integer, each integer between the minimum and maximum values ​​of the range is included. In addition, when multiple ranges are provided to describe features or characteristics, the ranges can be merged. In other words, unless otherwise specified, all ranges disclosed herein should be understood to include any and all subranges included therein.

[0026] In the present application, there is no particular limitation on the specific dispersion and stirring treatment methods.

[0027] Unless otherwise specified, the components, raw materials or instruments used in the embodiments and comparative examples of the present invention are all commercially available raw materials or instruments, and the components and raw materials used in each parallel experiment are all of the same kind.

[0028] Wherein, the raw materials of the embodiments and comparative examples are from the following sources:

[0029] Among them, hydrolyzed sodium hyaluronate: weight average molecular weight between 3000 and 10000, from Huaxi Biotechnology, brand name Nano Highly active ultra-low molecular weight sodium hyaluronate (or Highly active oligomeric sodium hyaluronate).

[0030] Yeast / rice fermentation product filtrate: Angel Yeast Co., Ltd., brand FC01.

[0031] Thermus thermophilus fermentation filtrate: Hangzhou Umada Biotechnology.

[0032] Soy lecithin: Shanghai Yuanye Biological, product number S30869.

[0033] PEG-40 hydrogenated castor oil: Guangzhou Yiwan Biological, brand name HK-HCO40.

[0034] PEG-60 hydrogenated castor oil: Guangzhou Yiwan Biological, brand name HK-HCO60.

[0035] Sodium carboxymethyl cellulose-1: weight average molecular weight is 90500, viscosity of 2wt% aqueous solution at 25°C is 25-50mPa.s, degree of substitution is 0.7, Ashland, brand 7L9EP.

[0036] Sodium carboxymethyl cellulose-2: weight average molecular weight is 90500, viscosity of 2wt% aqueous solution at 25°C is 50-100mPa.s, degree of substitution is 0.7, Ashland, brand 7M1FPH.

[0037] Sodium carboxymethyl cellulose-3: weight average molecular weight is 90500, viscosity of 2wt% aqueous solution at 25°C is 400-600mPa.s, degree of substitution is 0.7, Ashland, brand 7MFPH.

[0038] Sodium carboxymethyl cellulose-4: weight average molecular weight is 395,000, viscosity of 2wt% aqueous solution at 25°C is 200-800mPa.s, degree of substitution is 0.7, Ashland, brand 7M8SFPH.

[0039] The remaining raw materials are of conventional commercial cosmetic grade.

[0040] The embodiment of the present application provides a penetration-enhancing composition, comprising the following components in parts by weight: 0.5 to 8 parts of hydrolyzed sodium hyaluronate, 5 to 20 parts of a stabilizer, 12 to 25 parts of a yeast / rice fermentation product filtrate, and 40 to 80 parts of a solvent;

[0041] The stabilizer comprises decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose and a polyethylene glycol surfactant in a mass ratio of (0.05-0.4):(0.05-0.4):(0.08-0.5):1.

[0042] Among them, hydrolyzed sodium hyaluronate (serial number 06354 in the 2021 edition of the used cosmetic raw materials catalog) has excellent permeability. It can promote the penetration of active ingredients into the deep layers of the skin without damaging the skin barrier, gently release the active ingredients, promote effective absorption by the skin, and truly exert the efficacy of its ingredients. At the same time, hydrolyzed sodium hyaluronate can repair damaged cells, repair the skin barrier, increase cell activity, reduce the damage of the external environment to skin cells, penetrate into the subcutaneous tissue, promote the regeneration of subcutaneous cells, and accelerate skin metabolism.

[0043] Among them, yeast / rice fermentation product filtrate (serial number 03446 of the 2021 version of the used cosmetic raw materials catalog): it is rich in oligosaccharides, organic acids (fruit acids), amino acids, small molecule peptides, etc., which can quickly enter the dermis through the gaps in the stratum corneum, enhance the skin's absorption capacity, and help other skin care ingredients to be better absorbed and utilized by the skin. It can also promote the renewal and metabolism of skin cells, making the skin healthier and more vibrant. It promotes the activity of fibroblasts and the proliferation of collagen, elastic fibers and hyaluronic acid, activates cell membrane water channel proteins, and endogenously increases the water content of the skin. The yeast / rice fermentation product filtrate can penetrate into the skin, regulate the water and oil balance of the skin, and improve the oil secretion of the skin. It repairs the barrier function of the dermal matrix and supplements the skin's own filaggrin or underlying fibers, thereby brightening the skin tone and improving the skin texture. The yeast / rice fermentation product filtrate also has an antioxidant effect and can improve the stability of the composition.

[0044] Among them, the present invention uses decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose, and polyethylene glycol surfactants as stabilizers. Decapeptide-4 can help open the passage between cells, promote the penetration and absorption of biomacromolecules, promote the active ingredients to penetrate deeply into the bottom layer of the skin, and improve the absorption efficiency of the active ingredients in the skin. At the same time, decapeptide-4 can soothe sensitivity, repair the stratum corneum, and reduce the sensitivity of the skin; it is added to the system in the form of a stabilizer. The composite stabilizer can not only improve the stability of the system, but also form intermolecular hydrogen bonds with water to increase the intermolecular force. The molecules can be mutually adsorbed and cross-linked to effectively improve the stability of the system, and can also reduce surface tension, improve the permeability and wettability of the liquid. At the same time, the positively charged groups can interact with negatively charged cells to destroy the permeability of the cell membrane, thereby changing the permeability of the cells. The stabilizer also has a certain soothing effect, creates conditions for the penetration of active ingredients, and maintains the water-oil balance of the skin.

[0045] The present invention creatively combines hydrolyzed sodium hyaluronate, a stabilizer, and a yeast / rice fermentation product filtrate according to the above-mentioned specific dosages. Under the joint action of hydrolyzed sodium hyaluronate, a stabilizer, and a yeast / rice fermentation product filtrate, the surface tension is effectively reduced, the permeability and wettability of the liquid are improved, and the permeability of the cell membrane is destroyed. On the basis of not destroying the skin barrier, the effective ingredients are promoted to penetrate into the deep layers of the skin, the effective ingredients are gently released, and the effective absorption by the skin is promoted. Based on the complex action mechanism of hydrolyzed sodium hyaluronate, a stabilizer, and a yeast / rice fermentation product filtrate on the skin, the selection and ratio of the three ingredients also have a high specific matching. If the types in the composition are replaced or the dosages of the three are changed, the penetration-promoting effect will be significantly reduced.

[0046] In one embodiment, the following components are included in parts by weight: 2 to 6 parts of hydrolyzed sodium hyaluronate, 12 to 20 parts of stabilizer, 18 to 22 parts of yeast / rice fermentation product filtrate, and 56 to 64 parts of solvent. In particular, when the amount of each raw material is within this range, the compatibility is better, the synergistic effect is more obvious, and the penetration-enhancing effect can be further improved.

[0047] In one embodiment, the polyethylene glycol surfactant includes at least one of PEG-4 dilaurate, PEG-40 hydrogenated castor oil, and PEG-60 hydrogenated castor oil.

[0048] In one embodiment, the solvent includes at least one of isononyl isononanoate, dimethyl isosorbide, and an alcohol solvent.

[0049] In one embodiment, the solvent comprises isononyl isononanoate, dimethyl isosorbide and an alcohol solvent in a mass ratio of (0.1-0.4):(0.2-0.5):1.

[0050] Among them, dimethyl isosorbide has a strong function of promoting skin penetration, and is gentle and does not irritate the skin. It has a very strong dissolving power. It promotes active ingredients to break through the epidermal barrier and penetrate deep into the epidermis by dissolving the oil on the skin; among them, isononyl isononanoate can improve the compatibility of the system, promote the active ingredients in the product to quickly penetrate into the skin, accelerate absorption and exert efficacy, and it can form a thin film on the surface of the skin, effectively lock moisture, prevent moisture evaporation, thereby enhancing the skin's moisturizing ability, and at the same time can enhance the skin's barrier function and improve the skin's resistance to the external environment. It can block the damage caused to the skin by external things; among them, alcohol solvents can increase the solubility of active ingredients, improve the dispersion effect of active ingredients in the stratum corneum, prolong the action time of active ingredients, and indirectly increase the transdermal amount of active substances; the present invention uses isononyl isononanoate, dimethyl isosorbide and alcohol solvents as solvents, which can not only improve the compatibility of the system, promote the dissolution and dispersion of each component, but also effectively improve the penetration effect.

[0051] In one embodiment, the alcohol solvent includes at least one of glycerol, 1,2-propylene glycol, 2,3-propylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, 1,2-pentanediol, and isoprene glycol.

[0052] In one embodiment, the stabilizer includes decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose, and a polyethylene glycol surfactant in a mass ratio of (0.08-0.2):(0.08-0.2):(0.1-0.3):1.

[0053] In one embodiment, the weight average molecular weight of the sodium carboxymethyl cellulose is 90500-250000, and the viscosity of a 2wt% aqueous solution of the sodium carboxymethyl cellulose at 25°C is 25-100mPa.s. In particular, the use of sodium carboxymethyl cellulose with such a molecular weight and viscosity can better improve the stability of the system, increase the intermolecular force, and the molecules can be mutually adsorbed and cross-linked to effectively improve the stability of the system. At the same time, it can also reduce surface tension and improve the permeability and wettability of the liquid.

[0054] In one embodiment, the weight average molecular weight of the hydrolyzed sodium hyaluronate is 3,000 to 10,000.

[0055] In one embodiment, the mass ratio of the sum of the mass of the hydrolyzed sodium hyaluronate and the yeast / rice fermentation product filtrate to the mass of the stabilizer is (1.1-2.5):1.

[0056] In one embodiment, the mass ratio of the sum of the masses of the hydrolyzed sodium hyaluronate and the yeast / rice fermentation product filtrate to the stabilizer is (1.625-2):1. By controlling the mass ratio within this range, the intermolecular force can be increased, and the molecules can be adsorbed and cross-linked with each other to effectively improve the stability of the system. At the same time, the surface tension can be reduced, and the permeability and wettability of the liquid can be increased within this range, which can better promote the synergy of the three and further improve the penetration-promoting effect.

[0057] One embodiment of the present application provides a method for preparing a penetration-enhancing composition, comprising the following steps:

[0058] The hydrolyzed sodium hyaluronate, the stabilizer, the yeast / rice fermentation product filtrate and the solvent are uniformly mixed to obtain a penetration-enhancing composition.

[0059] One embodiment of the present application provides an application of a penetration-enhancing composition in the preparation of cosmetics.

[0060] In one embodiment, the cosmetic is in the form of an aqueous solution, emulsion, cream, gel, mask or essence.

[0061] In one embodiment, the mass percentage of the penetration-enhancing composition in the cosmetic is 0.001 to 20%.

[0062] In one embodiment, the mass percentage of the penetration-enhancing composition in the cosmetic is 0.01 to 10%.

[0063] In one embodiment, the mass percentage of the penetration-enhancing composition in the cosmetic is 0.1-5%.

[0064] In one embodiment, the cosmetics acceptable auxiliary materials include but are not limited to at least one of moisturizers, emollients, emulsifiers, antioxidants, flavors, and pigments.

[0065] In one embodiment, suitable moisturizers include, but are not limited to, at least one of panthenol, hydroxyethyl urea, polyethylene glycol, xylitol, maltose, sodium polyglutamate, erythritol, mannitol, glucose, lactose, inositol, trehalose, and hydrogenated starch hydrolysate.

[0066] In one embodiment, suitable emollients include, but are not limited to, at least one of isododecane, isohexadecane, caprylic / capric triglyceride, pentaerythrityl tetraisostearate, dimethicone, isononyl isononanoate, diisostearyl malate, phytosteryl macadamia oleate, squalane, hexyl laurate, castor oil, hydrogenated polyisobutene, octyldodecanol, shea butter, dicaprylyl carbonate, jojoba oil, lanolin, sweet almond oil, dicaprylyl adipate, and coconut oil-caprylate / caprate.

[0067] In one embodiment, suitable emulsifiers include, but are not limited to, at least one of glyceryl stearate, polyglyceryl-10 stearate, polyglyceryl-10 laurate, polyglyceryl-10 myristate, polyglyceryl-5 trioleate, PPG-13-decyltetradecyl alcohol polyether-24, sodium stearoyl glutamate, steareth-2, steareth-21, and hydrogenated lecithin.

[0068] In one embodiment, suitable antioxidants include, but are not limited to, ascorbic acid and its derivatives, resveratrol, pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate), arbutin, tocopherol (vitamin E), sodium metabisulfite, and combinations thereof.

[0069] In one embodiment, suitable colorants include, but are not limited to, white, black, yellow, blue, green, pink, red, orange, purple, indigo, brown, and the like, and combinations thereof.

[0070] The following examples are provided to facilitate understanding of the present invention. These examples are not provided to limit the scope of the claims.

[0071] Example 1

[0072] A penetration-enhancing composition comprises the following components in parts by weight: 7 parts of hydrolyzed sodium hyaluronate, 14 parts of a stabilizer, 21 parts of a yeast / rice fermentation product filtrate, and 58 parts of a solvent.

[0073] The stabilizer includes decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose-1, and PEG-40 hydrogenated castor oil in a mass ratio of 0.1:0.15:0.15:1.

[0074] The solvent comprises isononyl isononanoate, dimethyl isosorbide and 1,3-propylene glycol in a mass ratio of 0.2:0.3:1.

[0075] The mass ratio of the sum of the mass of the hydrolyzed sodium hyaluronate and the filtrate of the yeast / rice fermentation product to the mass of the stabilizer is 2:1.

[0076] The preparation method of the penetration-promoting composition comprises the following steps: evenly mixing hydrolyzed sodium hyaluronate, a stabilizer, a yeast / rice fermentation product filtrate and a solvent to obtain the penetration-promoting composition.

[0077] Example 2

[0078] The difference between Example 2 and Example 1 is that the amounts of hydrolyzed sodium hyaluronate, stabilizer, yeast / rice fermentation product filtrate, and solvent are different.

[0079] A penetration-enhancing composition comprises the following components in parts by weight: 6 parts of hydrolyzed sodium hyaluronate, 12 parts of a stabilizer, 18 parts of a yeast / rice fermentation product filtrate, and 64 parts of a solvent.

[0080] Example 3

[0081] The difference between Example 3 and Example 1 is that the amounts of hydrolyzed sodium hyaluronate, stabilizer, yeast / rice fermentation product filtrate, and solvent are different.

[0082] A penetration-enhancing composition comprises the following components in parts by weight: 2 parts of hydrolyzed sodium hyaluronate, 20 parts of a stabilizer, 22 parts of a yeast / rice fermentation product filtrate, and 56 parts of a solvent.

[0083] Example 4

[0084] The difference between Example 4 and Example 1 is that the amounts of hydrolyzed sodium hyaluronate, stabilizer, yeast / rice fermentation product filtrate, and solvent are different.

[0085] A penetration-enhancing composition comprises the following components in parts by weight: 0.5 parts of hydrolyzed sodium hyaluronate, 20 parts of a stabilizer, 12 parts of a yeast / rice fermentation product filtrate, and 67.5 parts of a solvent.

[0086] Example 5

[0087] The difference between Example 5 and Example 1 is that the amounts of hydrolyzed sodium hyaluronate, stabilizer, yeast / rice fermentation product filtrate, and solvent are different.

[0088] A penetration-enhancing composition comprises the following components in parts by weight: 8 parts of hydrolyzed sodium hyaluronate, 12 parts of a stabilizer, 25 parts of a yeast / rice fermentation product filtrate, and 55 parts of a solvent.

[0089] Example 6

[0090] The difference between Example 6 and Example 1 is that the mass ratio of the sum of the masses of hydrolyzed sodium hyaluronate and the filtrate of the yeast / rice fermentation product to the stabilizer is different.

[0091] A penetration-enhancing composition comprises the following components in parts by weight: 7.5 parts of hydrolyzed sodium hyaluronate, 18 parts of a stabilizer, 16.5 parts of a yeast / rice fermentation product filtrate, and 58 parts of a solvent.

[0092] The mass ratio of the sum of the mass of the hydrolyzed sodium hyaluronate and the yeast / rice fermentation product filtrate to the mass of the stabilizer is 1.625:1.

[0093] Example 7

[0094] The difference between Example 7 and Example 1 is that the mass ratio of the sum of the masses of hydrolyzed sodium hyaluronate and the filtrate of the yeast / rice fermentation product to the stabilizer is different.

[0095] A penetration-enhancing composition comprises the following components in parts by weight: 8 parts of hydrolyzed sodium hyaluronate, 20 parts of a stabilizer, 14 parts of a yeast / rice fermentation product filtrate, and 58 parts of a solvent.

[0096] The mass ratio of the sum of the mass of the hydrolyzed sodium hyaluronate and the yeast / rice fermentation product filtrate to the mass of the stabilizer is 1.1:1.

[0097] Example 8

[0098] The difference between Example 8 and Example 1 is that the mass ratio of the sum of the masses of hydrolyzed sodium hyaluronate and the filtrate of the yeast / rice fermentation product to the stabilizer is different.

[0099] A penetration-enhancing composition comprises the following components in parts by weight: 5 parts of hydrolyzed sodium hyaluronate, 12 parts of a stabilizer, 25 parts of a yeast / rice fermentation product filtrate, and 58 parts of a solvent.

[0100] The mass ratio of the sum of the mass of the hydrolyzed sodium hyaluronate and the filtrate of the yeast / rice fermentation product to the mass of the stabilizer is 2.5:1.

[0101] Example 9

[0102] The difference between Example 9 and Example 1 is that the mass ratios of decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose-1, and PEG-40 hydrogenated castor oil in the stabilizer are different.

[0103] The stabilizer includes decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose-1, and PEG-40 hydrogenated castor oil in a mass ratio of 0.08:0.08:0.3:1.

[0104] Example 10

[0105] The difference between Example 10 and Example 1 is that the mass ratios of decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose-1, and PEG-40 hydrogenated castor oil in the stabilizer are different.

[0106] The stabilizer comprises decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose-1, and PEG-40 hydrogenated castor oil in a mass ratio of 0.2:0.2:0.1:1.

[0107] Embodiment 11

[0108] The difference between Example 11 and Example 1 is that the mass ratios of decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose-1, and PEG-40 hydrogenated castor oil in the stabilizer are different.

[0109] The stabilizer includes decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose-1, and PEG-40 hydrogenated castor oil in a mass ratio of 0.05:0.05:0.5:1.

[0110] Example 12

[0111] The difference between Example 12 and Example 1 is that the mass ratios of decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose-1, and PEG-40 hydrogenated castor oil in the stabilizer are different.

[0112] The stabilizer includes decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose-1, and PEG-40 hydrogenated castor oil in a mass ratio of 0.4:0.4:0.08:1.

[0113] Example 13

[0114] The difference between Example 13 and Example 1 is that Example 13 uses an equal amount of sodium carboxymethyl cellulose-2 to replace sodium carboxymethyl cellulose-1.

[0115] Embodiment 14

[0116] The difference between Example 14 and Example 1 is that Example 14 uses an equal amount of sodium carboxymethyl cellulose-3 to replace sodium carboxymethyl cellulose-1.

[0117] Embodiment 15

[0118] The difference between Example 15 and Example 1 is that Example 15 uses an equal amount of sodium carboxymethyl cellulose-4 to replace sodium carboxymethyl cellulose-1.

[0119] Example 16

[0120] The difference between Example 16 and Example 1 is that Example 16 uses an equal amount of PEG-60 hydrogenated castor oil to replace PEG-40 hydrogenated castor oil.

[0121] Embodiment 17

[0122] The difference between Example 17 and Example 1 is that the mass ratios of isononyl isononanoate, dimethyl isosorbide and 1,3-propylene glycol in the solvent are different.

[0123] The solvent comprises isononyl isononanoate, dimethyl isosorbide and 1,3-propylene glycol in a mass ratio of 0.1:0.5:1.

[0124] Embodiment 18

[0125] The difference between Example 18 and Example 1 is that the mass ratios of isononyl isononanoate, dimethyl isosorbide and 1,3-propylene glycol in the solvent are different.

[0126] The solvent comprises isononyl isononanoate, dimethyl isosorbide and 1,3-propylene glycol in a mass ratio of 0.4:0.2:1.

[0127] Embodiment 19

[0128] The difference between Example 19 and Example 1 is that the solvent is single isosorbide dimethyl ether.

[0129] Embodiment 20

[0130] The difference between Example 20 and Example 1 is that the solvent is a single 1,3-propylene glycol.

[0131] Comparative Example 1

[0132] The difference between Comparative Example 1 and Example 1 is that the amounts of hydrolyzed sodium hyaluronate, stabilizer, yeast / rice fermentation product filtrate, and solvent are not within the scope of the present invention.

[0133] A penetration-enhancing composition comprises the following components in parts by weight: 0.2 parts of hydrolyzed sodium hyaluronate, 25 parts of a stabilizer, 30 parts of a yeast / rice fermentation product filtrate, and 44.8 parts of a solvent.

[0134] Comparative Example 2

[0135] The difference between Comparative Example 2 and Example 1 is that the amounts of hydrolyzed sodium hyaluronate, stabilizer, yeast / rice fermentation product filtrate, and solvent are not within the scope of the present invention.

[0136] A penetration-enhancing composition comprises the following components in parts by weight: 12 parts of hydrolyzed sodium hyaluronate, 2 parts of a stabilizer, 8 parts of a yeast / rice fermentation product filtrate, and 78 parts of a solvent.

[0137] Comparative Example 3

[0138] The difference between Comparative Example 3 and Example 1 is that Comparative Example 3 does not contain hydrolyzed sodium hyaluronate.

[0139] A penetration-enhancing composition comprises the following components in parts by weight: 14 parts of a stabilizer, 21 parts of a yeast / rice fermentation product filtrate, and 58 parts of a solvent.

[0140] Comparative Example 4

[0141] The difference between Comparative Example 4 and Example 1 is that Comparative Example 4 does not contain a stabilizer.

[0142] A penetration-enhancing composition comprises the following components in parts by weight: 7 parts of hydrolyzed sodium hyaluronate, 21 parts of yeast / rice fermentation product filtrate, and 58 parts of solvent.

[0143] Comparative Example 5

[0144] The difference between Comparative Example 5 and Example 1 is that Comparative Example 5 does not contain yeast / rice fermentation product filtrate.

[0145] A penetration-enhancing composition comprises the following components in parts by weight: 7 parts of hydrolyzed sodium hyaluronate, 14 parts of a stabilizer, and 58 parts of a solvent.

[0146] Comparative Example 6

[0147] The difference between Comparative Example 6 and Example 1 is that Comparative Example 6 does not contain hydrolyzed sodium hyaluronate, and the total amount of hydrolyzed sodium hyaluronate, stabilizer, and yeast / rice fermentation product filtrate is consistent with that in Example 1 (the amount of hydrolyzed sodium hyaluronate is evenly distributed in equal proportion to the stabilizer and yeast / rice fermentation product filtrate).

[0148] A penetration-enhancing composition comprises the following components in parts by weight: 17.8 parts of a stabilizer, 25.2 parts of a yeast / rice fermentation product filtrate, and 58 parts of a solvent.

[0149] Comparative Example 7

[0150] The difference between Comparative Example 7 and Example 1 is that Comparative Example 7 does not contain a stabilizer, and the total amount of hydrolyzed sodium hyaluronate, stabilizer, and yeast / rice fermentation product filtrate is consistent with that in Example 1 (the amount of stabilizer is evenly distributed in equal proportion to the hydrolyzed sodium hyaluronate and yeast / rice fermentation product filtrate).

[0151] A penetration-enhancing composition comprises the following components in parts by weight: 10.5 parts of hydrolyzed sodium hyaluronate, 31.5 parts of yeast / rice fermentation product filtrate, and 58 parts of solvent.

[0152] Comparative Example 8

[0153] The difference between Comparative Example 8 and Example 1 is that Comparative Example 8 does not contain yeast / rice fermentation product filtrate, and the total amount of hydrolyzed sodium hyaluronate, stabilizer, and yeast / rice fermentation product filtrate is consistent with that in Example 1 (the amount of yeast / rice fermentation product filtrate is evenly distributed to the hydrolyzed sodium hyaluronate and stabilizer in equal proportion).

[0154] A penetration-enhancing composition comprises the following components in parts by weight: 14 parts of hydrolyzed sodium hyaluronate, 28 parts of a stabilizer, and 58 parts of a solvent.

[0155] Comparative Example 9

[0156] The difference between Comparative Example 9 and Example 1 is that an equal amount of glycerol glucoside is used to replace hydrolyzed sodium hyaluronate.

[0157] A penetration-enhancing composition comprises the following components in parts by weight: 7 parts of glycerol glucoside, 14 parts of a stabilizer, 21 parts of a yeast / rice fermentation product filtrate, and 58 parts of a solvent.

[0158] Comparative Example 10

[0159] The difference between Comparative Example 10 and Example 1 is that an equal amount of Thermus thermophilus fermentation filtrate is used to replace the yeast / rice fermentation product filtrate.

[0160] A penetration-enhancing composition comprises the following components in parts by mass: 7 parts of hydrolyzed sodium hyaluronate, 14 parts of a stabilizer, 21 parts of a fermentation filtrate of Thermus thermophilus, and 58 parts of a solvent.

[0161] Comparative Example 11

[0162] The difference between Comparative Example 11 and Example 1 is that the mass ratio of decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose-1, and PEG-40 hydrogenated castor oil in the stabilizer is not within the scope of the present invention.

[0163] The stabilizer includes decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose-1, and PEG-40 hydrogenated castor oil in a mass ratio of 0.01:0.01:0.8:1.

[0164] Comparative Example 12

[0165] The difference between Comparative Example 12 and Example 1 is that the mass ratio of decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose-1, and PEG-40 hydrogenated castor oil in the stabilizer is not within the scope of the present invention.

[0166] The stabilizer includes decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose-1, and PEG-40 hydrogenated castor oil in a mass ratio of 0.5:0.5:0.01:1.

[0167] Test Case

[0168] 1. With retinol as the target active ingredient, the composition of the embodiment and the comparative example and retinol were prepared into a test substance at a ratio of 95:5 to examine the penetration-enhancing effect of the penetration-enhancing composition of the embodiment and the comparative example.

[0169] The suckling pig skin-Franzcell permeation diffusion cell test was adopted (the instrument is a TK-type transdermal absorption tester, and the instrument operation method can be referred to), and the national standard GBT27818-2011 was referred to.

[0170] The specific method is as follows: remove hair and subcutaneous tissue from fresh pig back skin, clean it, dry it and cut it into suitable sizes for later use. Fix the pig back skin between the supply chamber and the receiving chamber of the TK transdermal absorption tester. The receiving solution is an isotonic PBS buffer solution. The test solution is the composition of the embodiment and the comparative example. Five groups of samples are tested in parallel, and the average value is taken. The transdermal test is carried out in a 37°C circulating water bath. Take 0.5mL of sample at 4h and 12h after the start of the test, and add 0.5mL of PBS after sampling. The sample is filtered through a 0.22μm filter membrane and used as a test sample. The diffusion percentage of retinol in the 4h and 12h samples is detected and calculated respectively.

[0171] Among them, the content of retinol was tested using the determination method of "Guangdong Cosmetics Association Group Standard T / GDCA 005-2021 Retinol, Retinol Acetate, Retinol Palmitate, and Hydroxypinacolone Retinoate in Cosmetics".

[0172] Table 1

[0173]

[0174]

[0175] It can be seen from Table 1 that the penetration-enhancing composition of the present invention has an excellent penetration-enhancing effect and can effectively promote the penetration of active ingredients.

[0176] By comparing Example 1 with Comparative Examples 3 to 10, it can be seen that under the system of the present invention, the hydrolyzed sodium hyaluronate, the stabilizer, and the yeast / rice fermentation product filtrate have a significant synergistic effect in promoting penetration. The lack of any one of them or the use of other penetration enhancers to replace any one of them will lead to a significant decrease in the penetration effect.

[0177] By comparing Example 1 with Comparative Examples 11 to 12, it can be seen that the present invention significantly improves the penetration-enhancing effect by adopting decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose, and polyethylene glycol surfactants in a mass ratio of (0.05 to 0.4): (0.05 to 0.4): (0.08 to 0.5): 1.

[0178] By comparing Examples 1 to 5 with Comparative Examples 1 to 2, it can be seen that the present invention controls the amount of each raw material to: 0.5 to 8 parts of hydrolyzed sodium hyaluronate, 5 to 20 parts of stabilizer, 12 to 25 parts of yeast / rice fermentation product filtrate, and 40 to 80 parts of solvent; the compatibility of each raw material is better, and the penetration-enhancing effect is significantly improved.

[0179] By comparing Examples 1 to 3 with Examples 4 to 5, it can be seen that the present invention further improves the penetration-enhancing effect by controlling the amount of each raw material to: 2 to 6 parts of hydrolyzed sodium hyaluronate, 12 to 20 parts of stabilizer, 18 to 22 parts of yeast / rice fermentation product filtrate, and 56 to 64 parts of solvent.

[0180] By comparing Example 1 with Examples 6 to 8, it can be seen that the present invention further improves the penetration-enhancing effect by controlling the mass ratio of the sum of the mass of hydrolyzed sodium hyaluronate and the filtrate of the yeast / rice fermentation product to the mass ratio of the stabilizer to (1.625-2):1.

[0181] By comparing Example 1 with Examples 9 to 12, it can be seen that the present invention further improves the penetration-enhancing effect by using decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose, and polyethylene glycol surfactants in a mass ratio of (0.08 to 0.2): (0.08 to 0.2): (0.1 to 0.3): 1.

[0182] By comparing Example 1 with Examples 13 to 15, it can be seen that the present invention uses sodium carboxymethyl cellulose with a weight average molecular weight of 90,500 to 250,000 and a viscosity of 25 to 100 mPa.s in a 2wt% aqueous solution at 25°C, which further improves the penetration-enhancing effect.

[0183] By comparing Examples 1, 17, and 18 with Examples 19 to 20, it can be seen that the use of isononyl isononanoate, dimethyl isosorbide, and alcohol solvents in a mass ratio of (0.1 to 0.4): (0.2 to 0.5): 1 further improves the penetration-enhancing effect.

[0184] 2. Stability test

[0185] The penetration-enhancing compositions of the embodiments and comparative examples were subjected to stability tests. The heat resistance test was to stand at 48°C for three months and observe the appearance, color and smell thereof; the cold resistance test was to stand at -18°C for three months and observe the appearance, color and smell thereof; the normal temperature test was to stand at 25°C for three months and observe the appearance, color and smell thereof; the hot and cold cycle test was to store at 45°C, normal temperature and -18°C for 24 hours each, cycle 10 times, and observe the appearance, color and smell thereof. The test results are shown in Table 2.

[0186] Table 2

[0187]

[0188]

[0189] It can be seen from Table 2 that the penetration enhancing composition of the present invention has excellent stability, wherein the stabilizer is the key to achieving stability. The stabilizer of the present invention significantly improves the stabilization effect. If the raw material ratio of the stabilizer is changed, high temperature stability and cyclic stability cannot be achieved.

[0190] 3. Irritation test

[0191] The test was carried out according to the method of SNT 2329-2009, and the results were evaluated by the stimulation scoring method.

[0192] The specific scores are shown in Table 3, and the evaluation results are shown in Table 4.

[0193] Table 3

[0194] Stimulus score Irritation classification IS<1 Non-irritating 1≤IS<5 Mild irritation 5≤IS<9 Moderate irritation IS ≥ 10 Strong irritant / corrosive

[0195] Table 4

[0196]

[0197]

[0198] It can be seen from Table 4 that the penetration-enhancing composition of the present invention is mild and non-irritating and has good safety.

[0199] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A penetration-enhancing composition, characterized in that The invention comprises the following components in parts by weight: 0.5 to 8 parts of hydrolyzed sodium hyaluronate, 5 to 20 parts of a stabilizer, 12 to 25 parts of a yeast / rice fermentation product filtrate, and 40 to 80 parts of a solvent; The stabilizer comprises decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose and a polyethylene glycol surfactant in a mass ratio of (0.05-0.4):(0.05-0.4):(0.08-0.5):

1.

2. The penetration-enhancing composition according to claim 1, characterized in that The invention comprises the following components in parts by weight: 2 to 6 parts of hydrolyzed sodium hyaluronate, 12 to 20 parts of stabilizer, 18 to 22 parts of yeast / rice fermentation product filtrate, and 56 to 64 parts of solvent.

3. The penetration-promoting composition according to claim 1, characterized in that The polyethylene glycol surfactant includes at least one of PEG-4 dilaurate, PEG-40 hydrogenated castor oil and PEG-60 hydrogenated castor oil.

4. The penetration-enhancing composition according to claim 1, characterized in that The solvent includes at least one of isononyl isononanoate, dimethyl isosorbide, and alcohol solvents.

5. The penetration-promoting composition according to claim 4, characterized in that The solvent comprises isononyl isononanoate, isosorbide dimethyl ether and an alcohol solvent in a mass ratio of (0.1-0.4):(0.2-0.5):

1.

6. The penetration-promoting composition according to claim 4, characterized in that The alcohol solvent includes at least one of glycerol, 1,2-propylene glycol, 1,3-propylene glycol, 2,3-butylene glycol, 1,4-butylene glycol, 1,2-pentanediol, and isoprene glycol.

7. The penetration-enhancing composition according to claim 1, characterized in that The stabilizer comprises decapeptide-4, soybean lecithin, sodium carboxymethyl cellulose and a polyethylene glycol surfactant in a mass ratio of (0.08-0.2):(0.08-0.2):(0.1-0.3):

1.

8. The penetration-enhancing composition according to claim 1, characterized in that The weight average molecular weight of the sodium carboxymethyl cellulose is 90,500 to 250,000, and the viscosity of a 2 wt % aqueous solution of the sodium carboxymethyl cellulose at 25° C. is 25 to 100 mPa.s.

9. The penetration-enhancing composition according to claim 1, characterized in that The weight average molecular weight of the hydrolyzed sodium hyaluronate is 3,000 to 10,000.

10. The penetration-enhancing composition according to claim 1, characterized in that The mass ratio of the sum of the mass of the hydrolyzed sodium hyaluronate and the yeast / rice fermentation product filtrate to the mass of the stabilizer is (1.1-2.5):

1.

11. The penetration-enhancing composition according to claim 1, characterized in that The mass ratio of the sum of the mass of the hydrolyzed sodium hyaluronate and the filtrate of the yeast / rice fermentation product to the mass of the stabilizer is (1.625-2):

1.

12. The method for preparing the penetration-enhancing composition according to any one of claims 1 to 11, characterized in that: The following steps are involved: The hydrolyzed sodium hyaluronate, the stabilizer, the yeast / rice fermentation product filtrate and the solvent are uniformly mixed to obtain a penetration-enhancing composition.

13. Use of the penetration-enhancing composition according to any one of claims 1 to 11 in the preparation of cosmetics.

14. The use according to claim 13, characterized in that The dosage form of the cosmetic is water solution, emulsion, cream, gel, facial mask or essence.

15. The use according to claim 13, characterized in that: The mass percentage of the penetration-promoting composition in the cosmetics is 0.001-20%.

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