Anti-oxidation repairing composition and cosmetics thereof

Abstract

The invention discloses an antioxidant repair composition and a cosmetic thereof, and the antioxidant repair composition is prepared from the following components in parts by mass: 0.1 to 10 parts of oat beta glucan solution, 0.01 to 2 parts of Idebenone, 0.01 to 10 parts of collagen solution, 0.1 to 10 parts of dipeptide diaminobutyrylbenzylamide diacetate solution, 0.01 to 10 parts of swan neck miraculous factor, 0.01 to 10 parts of face-tightening anti-wrinkle peptide and 0.01 to 5 parts of saccharide isomeride solution. The Idebenone is a mixture containing hydroxydecyl ubiquinone, and the Idebenone is a mixture containing hydroxydecyl The collagen solution is a mixed solution containing hydrolyzed collagen; the swan neck miraculous factor is a mixed solution containing a calabash extract, a lactobacillus fermentation extract and a lactobacillus / black mustard seed fermentation product extract; the face-tightening anti-wrinkle peptide is a mixed solution containing a sweet almond seed extract and hydrolyzed rice protein. The anti-oxidation repairing composition disclosed by the invention can realize a relatively strong anti-oxidation effect and a relatively strong skin repairing effect.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and in particular relates to an antioxidant repairing composition and cosmetics thereof. Background Art

[0002] As people's living standards improve, the need to prolong life and maintain a youthful appearance becomes stronger, especially in dealing with wrinkles, sagging skin and uneven skin tone caused by pigmentation. As the first line of defense between the human body and the external environment, the skin is more susceptible to external factors such as ultraviolet radiation and air pollution, making it the first place to show signs of aging.

[0003] Oxidative stress plays a vital role in the process of skin aging. When the production of free radicals (especially reactive oxygen species ROS) in the body exceeds the capacity of the body's natural antioxidant defense system, oxidative stress occurs, which can lead to DNA damage, increase the expression of multiple pro-inflammatory factors such as tumor necrosis factor-α, interleukin 1, interleukin 6, and interleukin 8, reduce the skin's own antioxidants, and produce matrix metalloproteinases (MMPs), which can degrade collagen and elastin in the dermis. Inflammatory reactions mediate skin damage, leading to impaired barrier function. Impaired barriers make it easier for ROS to attack the skin, further exacerbating skin aging and barrier damage.

[0004] Currently, antioxidant repair cosmetics on the market usually contain active ingredients such as vitamin C, vitamin E and polyphenols, which can effectively neutralize free radicals in the skin. By reducing the level of free radicals, such products can fight oxidative stress to a certain extent, thereby helping to improve skin quality and slow down the aging process. However, there are certain limitations to repairing skin problems by simply reducing free radicals, because the health of the skin is not only affected by free radicals, but also related to other factors, such as the natural aging process. Therefore, repairing the skin by simply reducing free radicals will make it difficult for the repair effect to meet consumers' expectations.

[0005] Therefore, there is an urgent need for an antioxidant repair composition and cosmetics thereof to solve the deficiencies of the prior art problems. Summary of the invention

[0006] In view of the above problems, an object of the present invention is to provide an antioxidant repairing composition and a cosmetic thereof, wherein the antioxidant repairing composition can achieve a strong antioxidant effect and skin repairing effect.

[0007] To achieve the above objectives, the first aspect of the present invention provides an antioxidant repair composition, which includes, by mass, 0.1 to 10 parts of oat beta-glucan solution, 0.01 to 2 parts of Idebenone, 0.01 to 10 parts of collagen solution, 0.1 to 10 parts of dipeptide diaminobutyryl benzylamide diacetate solution, 0.01 to 10 parts of swan neck miracle factor, 0.01 to 10 parts of firming and anti-wrinkle peptide, and 0.01 to 5 parts of carbohydrate isomer solution; Idebenone is a mixture containing hydroxydecyl ubiquinone; the collagen solution is a mixed solution containing hydrolyzed collagen; the swan neck miracle factor is a mixed solution containing gourd extract, lactic acid bacteria fermentation extract and lactobacillus / black mustard seed fermentation product extract; the firming and anti-wrinkle peptide is a mixed solution containing sweet almond seed extract and hydrolyzed rice protein.

[0008] Compared with the prior art, the antioxidant repair composition of the present invention selects seven substances, namely oat beta-glucan solution, Idebenone, collagen solution, dipeptide diaminobutyryl benzylamide diacetate solution, swan neck miracle factor, firming anti-wrinkle peptide, and carbohydrate isomer solution, as raw materials to achieve stronger antioxidant and skin repair effects. Its specific mechanism of action is shown below.

[0009] (1) Idebenone is a highly effective antioxidant with a structure similar to coenzyme Q10 but with a smaller molecular weight and easy penetration. It can scavenge free radicals, inhibit lipid peroxidation, and provide light protection. Although Idebenone has significant antioxidant capacity, given the complex and changeable process of skin aging and damage, it is difficult for a single ingredient to achieve the best effect. Therefore, in order to further enhance the antioxidant effect, this application also introduces firming and anti-wrinkle peptides and swan neck miracle factors. On the one hand, firming and anti-wrinkle peptides include sweet almond seed extract and hydrolyzed rice protein. The polyphenol compounds rich in sweet almond seeds are a powerful natural antioxidant that can effectively resist damage to the skin caused by the external environment, while hydrolyzed rice protein indirectly enhances the skin's ability to resist oxidative stress by promoting collagen synthesis and maintaining skin moisture balance. On the other hand, the Swan Neck Miracle Factor contains three active substances: gourd extract, lactic acid bacteria fermentation product, and lactobacillus / black mustard seed fermentation product extract. These three ingredients have different antioxidant properties. When these ingredients are used in combination with Idebenone, they can form a multi-level, wide-coverage antioxidant network, which not only enhances the overall antioxidant performance, but also ensures effective protection against different types of free radicals. Therefore, the present invention can enhance the effect of scavenging free radicals and provide all-round protection for the skin by combining Idebenone with firming and anti-wrinkle peptides and Swan Neck Miracle Factor.

[0010] (2) Skin health and repair is a complex biological process involving multiple levels of mechanisms. In order to achieve the best effect, this application combines active ingredients with different functions. Specifically: oat beta-glucan, as a water-soluble non-starch polysaccharide, can resist UV damage, promote immune protection, promote fibroblast growth and collagen synthesis, improve skin elasticity, accelerate wound healing and reduce scars. Collagen solution can directly provide the skin with the required structural protein to help restore skin elasticity and firmness, while oat beta-glucan can stimulate the production of collagen. Therefore, the combination of hydrolyzed collagen and oat beta-glucan can jointly promote the increase of collagen levels, thereby strengthening the skin structure; the lactic acid bacteria fermentation products and lactobacillus / black mustard seed fermentation product extracts contained in the swan neck miracle factor can provide microbial metabolites that are beneficial to skin health, help regulate the balance of skin microecology, and enhance barrier function. This prebiotic effect complements the barrier strengthening effect of oat beta-glucan and jointly improves skin health; it also introduces firming and anti-wrinkle peptides (sweet almond The active ingredients in oat seed extract and hydrolyzed rice protein can simulate the effects of certain signal molecules in the body, stimulating the skin to produce more collagen and other structural proteins. These ingredients work together with oat beta-glucan to not only promote collagen production, but also improve skin firmness and smoothness. The carbohydrate isomer solution can form a protective film on the skin surface to lock in moisture. It cooperates with the moisturizing properties of oat beta-glucan to provide a long-lasting moisturizing effect for the skin and combat dryness and aging caused by environmental factors. The dipeptide diaminobutyryl benzylamide diacetate solution can relieve fine lines caused by muscle contraction from the outside and smooth the skin. Therefore, this application aims to achieve a comprehensive skin repair effect and make the skin healthier by enhancing skin structure and elasticity, improving skin health, maintaining skin moisture balance and smoothing the skin through the interaction of the above six ingredients.

[0011] Furthermore, the oat beta glucan solution of the present invention is a mixed solution consisting of water, glycerol and oat beta glucan in a mass ratio of 70 to 80:10 to 20:1.2 to 1.6.

[0012] Further, the idebenone of the present invention is a mixture of hydroxydecyl ubiquinone, polysorbate-80, polyethylene glycol-8 and caprylic / capric triglyceride in a mass ratio of 9 to 11:52 to 56:15 to 20:15 to 20. Preferably, idebenone is a mixture of hydroxydecyl ubiquinone, polysorbate-80, polyethylene glycol-8 and caprylic / capric triglyceride in a mass ratio of 10:54:18:18.

[0013] Furthermore, the collagen solution of the present invention is a mixture of hydrolyzed collagen, water and butanediol in a mass ratio of 0.8-1.2:67-71:27-32. Preferably, the collagen solution is a mixture of hydrolyzed collagen, water and butanediol in a mass ratio of 1:69:30.

[0014] Furthermore, the dipeptide diaminobutyryl benzylamide diacetate solution of the present invention is a mixed solution consisting of water, glycerol and dipeptide diaminobutyryl benzylamide diacetate in a mass ratio of 70-80:20-30:0.09-0.12.

[0015] Furthermore, the swan neck miracle factor of the present invention is a mixture of water, 1,3-propylene glycol, glycerin, cucurbita serrata extract, lactic acid bacteria fermentation extract and lactobacillus / black mustard seed fermentation product extract in a mass ratio of 30-50:20-40:20-40:2-4:0.975-1.625:0.525-0.875.

[0016] Furthermore, the firming and anti-wrinkle peptide of the present invention is a mixture of water, sweet almond seed extract and hydrolyzed rice protein in a mass ratio of 88-92:5.8-6.8:3-3.5. Preferably, the firming and anti-wrinkle peptide is a mixture of water, sweet almond seed extract and hydrolyzed rice protein in a mass ratio of 90.6:6.2:3.2.

[0017] Furthermore, the saccharide isomer solution of the present invention is a mixed solution consisting of saccharide isomers and water in a mass ratio of 50-70:25-50.

[0018] Correspondingly, the second aspect of the present invention also provides a cosmetic, including a cosmetic external dosage form matrix, and also including the above-mentioned antioxidant repair composition.

[0019] Furthermore, the cosmetic external dosage form matrix of the present invention is selected from at least one of a thickener, a moisturizer, an antibacterial agent, a pH regulator and a colorant. DETAILED DESCRIPTION

[0020] The following is a further detailed description of the claims of the present invention in conjunction with specific implementation methods, but does not constitute any limitation to the present invention. Any limited modifications made by anyone within the scope of protection of the claims of the present invention are still within the scope of protection of the claims of the present invention.

[0021] The invention provides an antioxidant repairing composition, which comprises, by mass, 0.1 to 10 parts of oat beta-glucan solution, 0.01 to 2 parts of idebenone, 0.01 to 10 parts of collagen solution, 0.1 to 10 parts of dipeptide diaminobutyryl benzylamide diacetate solution, 0.01 to 10 parts of swan neck miracle factor, 0.01 to 10 parts of firming and anti-wrinkle peptide, and 0.01 to 5 parts of carbohydrate isomer solution; idebenone is a mixture containing hydroxydecyl ubiquinone; the collagen solution is a mixed solution containing hydrolyzed collagen; the swan neck miracle factor is a mixed solution containing gourd extract, lactic acid bacteria fermentation extract and lactobacillus / black mustard seed fermentation product extract; the firming and anti-wrinkle peptide is a mixed solution containing sweet almond seed extract and hydrolyzed rice protein.

[0022] Among them, the content of oat beta glucan solution can be but not limited to 0.1 parts, 0.5 parts, 1.0 parts, 1.5 parts, 2.5 parts, 3.5 parts, 5.0 parts, 6.5 parts, 7.0 parts, 8.5 parts, 9.0 parts, 10 parts. Preferably, the content of oat beta glucan solution is 0.2-7 parts. The oat beta glucan solution is a mixture of water, glycerol and oat beta glucan in a mass ratio of 70-80:10-20:1.2-1.6; for example, the mass ratio of water, glycerol and oat beta glucan can be but not limited to 75:15:1.5, 80:15:1.5, 70:20:1.6. Oat beta glucan solution has the effects of resisting ultraviolet damage, promoting immune protection, promoting the growth of fibroblasts and the synthesis of collagen, having good transdermal properties, anti-wrinkle and anti-aging, improving skin elasticity, accelerating wound healing, and fading scars.

[0023] Wherein, the content of Idebenone may be, but not limited to, 0.01, 0.1, 0.4, 0.8, 1.2, 1.5, and 2 parts. Preferably, the content of Idebenone is 0.1 to 1.5 parts. Idebenone is a mixture of hydroxydecylubiquinone, polysorbate-80, polyethylene glycol-8, and caprylic / capric triglyceride in a mass ratio of 9 to 11:52 to 56:15 to 20:15 to 20; for example, the mass ratio of hydroxydecylubiquinone, polysorbate-80, polyethylene glycol-8, and caprylic / capric triglyceride may be, but not limited to, 10:55:18:18, 9:52:15:20, and 11:56:20:15. Preferably, Idebenone is a mixture of hydroxydecylubiquinone, polysorbate-80, polyethylene glycol-8, and caprylic / capric triglyceride in a mass ratio of 10:54:18:18. Idebenone has the effects of scavenging free radicals, inhibiting lipid peroxidation, and resisting light protection.

[0024] Among them, the content of the collagen solution may be, but is not limited to, 0.01 parts, 0.05 parts, 0.1 parts, 1.0 parts, 2.4 parts, 3.8 parts, 4.2 parts, 5.5 parts, 7 parts, 8 parts, 9 parts, 9.5 parts, and 10 parts. Preferably, the content of the collagen solution is 0.05 to 2 parts. The collagen solution is a mixture of hydrolyzed collagen, water, and butanediol in a mass ratio of 0.8 to 1.2:67 to 71:27 to 32; such as the mass ratio of hydrolyzed collagen, water, and butanediol may be, but is not limited to, 1.0:70:30, 1.2:68:29, and 0.8:67:27. Preferably, the collagen solution is a mixture of hydrolyzed collagen, water, and butanediol in a mass ratio of 1:69:30. Collagen solution can provide high-quality amino acid raw materials for the synthesis of human collagen, promote the synthesis of collagen, and timely replenish the collagen lost in the human skin. It helps to maintain the special network structure of collagen in the skin, increase the firmness and elasticity of the skin, improve the skin's water retention capacity, reduce the formation of wrinkles, delay skin aging, and prevent or repair skin damage to a certain extent.

[0025] Wherein, the content of dipeptide diaminobutyryl benzylamide diacetate solution may be, but is not limited to, 0.1 parts, 0.5 parts, 1.0 parts, 2.5 parts, 3.8 parts, 4.0 parts, 4.5 parts, 5.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts. Preferably, the content of dipeptide diaminobutyryl benzylamide diacetate solution is 0.1 to 6 parts. The dipeptide diaminobutyryl benzylamide diacetate solution is a mixed solution of water, glycerol, and dipeptide diaminobutyryl benzylamide diacetate in a mass ratio of 70 to 80:20 to 30:0.09 to 0.12. For example, the mass ratio of water, glycerol, and dipeptide diaminobutyryl benzylamide diacetate may be, but is not limited to, 75:25:0.09, 70:30:0.12, and 80:20:0.1. The dipeptide diaminobutyroylbenzylamide diacetate solution simulates the function of botulinum toxin. It combines with muscle nicotinic acetylcholine receptors (mnAChR) to locally block the nerves that transmit muscle contraction information, relax the facial muscles, smooth out fine lines, and stimulate the production of collagen to increase skin elasticity and firmness. It also helps to maintain skin moisture, making the skin more hydrated, enhancing the skin's barrier function and preventing moisture loss.

[0026] Among them, the content of the swan neck miracle factor can be but not limited to 0.01 parts, 0.05 parts, 1.1 parts, 1.8 parts, 3.20 parts, 4.25 parts, 5.5 parts, 6.5 parts, 7.0 parts, 8.0 parts, 9.0 parts, and 10 parts. Preferably, the content of the swan neck miracle factor is 0.05-5 parts. The swan neck miracle factor is a mixture of water, 1,3-propylene glycol, glycerin, gourd extract, lactic acid bacteria fermentation extract, and lactobacillus / black mustard seed fermentation product extract in a mass ratio of 30-50:20-40:20-40:2-4:0.975-1.625:0.525-0.875. For example, the mass ratio of water, 1,3-propylene glycol, glycerin, cucurbitacin extract, lactic acid bacteria fermentation extract and lactobacillus / black mustard seed fermentation product extract can be, but is not limited to, 40:30:40:3:1.6:0.625, 35:25:36:3:1.225:0.65.

[0027] Among them, the content of the firming and anti-wrinkle peptide can be but not limited to 0.01 parts, 0.05 parts, 1.1 parts, 1.8 parts, 3.20 parts, 4.25 parts, 5.5 parts, 6.5 parts, 7.0 parts, 8.0 parts, 9.0 parts, and 10 parts. The content of the firming and anti-wrinkle peptide is preferably 0.05 to 6 parts. The firming and anti-wrinkle peptide is a mixture of water, sweet almond seed extract and hydrolyzed rice protein in a mass ratio of 88 to 92: 5.8 to 6.8: 3 to 3.5. For example, the mass ratio of water, sweet almond seed extract and hydrolyzed rice protein can be but not limited to 90: 6.2: 3.3, 88: 5.9: 3.5. Preferably, the firming and anti-wrinkle peptide is a mixture of water, sweet almond seed extract and hydrolyzed rice protein in a mass ratio of 90.6: 6.2: 3.2. Firming and anti-wrinkle peptides can promote fibroblast proliferation and improve cell metabolism, enhance collagen synthesis, significantly improve skin softness, minimize skin dullness and fatigue, repair visual signs of aging, and provide long-term skin lifting effects.

[0028] Among them, the content of the saccharide isomer solution can be but not limited to 0.01 parts, 0.1 parts, 0.5 parts, 1.0 parts, 2.5 parts, 3.8 parts, 4.0 parts, 4.5 parts, and 5.0 parts. The content of the saccharide isomer solution is preferably 0.1 to 3 parts. The saccharide isomer solution is a mixed solution of saccharide isomers and water in a mass ratio of 50 to 70:25 to 50. For example, the mass ratio of saccharide isomers to water can be but not limited to 60:40, 70:30, 65:35, and 50:50. The carbohydrate isomer solution has a unique composition, which is similar to the composition of carbohydrate complex (NMF) in human skin. Its unique combination with the skin ensures a deep moisturizing effect. It can upregulate the gene expression levels of filaggrin and hyaluronic acid synthase 3, promote the synthesis of NMF and hyaluronic acid, and improve the skin's water retention capacity. It can increase the gene expression level of acid sphingomyelinase and stimulate the synthesis of ceramide. After use, it has a deep moisturizing effect and reduces the irritation of harmful substances to the skin.

[0029] Correspondingly, the present invention also provides the use of the above-mentioned antioxidant repair composition in cosmetics, and the cosmetics can be formed by mixing the antioxidant repair composition with a matrix of a cosmetic external dosage form.

[0030] The dosage form of the cosmetics may be, but is not limited to, ointments, aqueous solutions, emulsions, essences and creams.

[0031] Wherein, the cosmetic external dosage form matrix is ​​selected from at least one of a thickener, a moisturizer, an antibacterial agent, a pH regulator and a colorant.

[0032] Among them, calculated by mass, the cosmetics include 0.05 to 1 parts of thickener, 1 to 20 parts of moisturizer, 0.1 to 2 parts of antibacterial agent, 0.005 to 0.2 parts of pH adjuster, 0.001 to 0.1 parts of colorant, 1 to 20 parts of antioxidant repair composition, and 70 to 90 parts of water.

[0033] The content of the thickener may be, but is not limited to, 0.05 part, 0.06 part, 0.07 part, 0.09 part, or 0.1 part; the thickener may specifically be, but is not limited to, carbomer.

[0034] Among them, the content of the moisturizer can be but is not limited to 1 part, 1.6 parts, 2.7 parts, 3.9 parts, 5.1 parts, 7.05 parts, 8.06 parts, 12 parts, 14 parts, 16 parts, 18 parts, 19 parts, and 20 parts; the moisturizer can be at least one of sodium hyaluronate, butylene glycol, and glycerol; specifically, the moisturizer can be 0.01-0.2 parts of sodium hyaluronate, 1-10 parts of butylene glycol, and 1-10 parts of glycerol.

[0035] The content of the antibacterial agent may be, but is not limited to, 0.1, 0.6, 1.3, 1.7, or 2.0 parts; the antibacterial agent may be at least one of 1,2-pentanediol, 1,2-hexanediol, and HL-01. Specifically, the antibacterial agent may be 0.1 to 1 part of 1,2-pentanediol, 0.2 to 1 part of 1,2-hexanediol, and 0.3 to 1 part of HL-01.

[0036] The content of the pH adjuster may be, but is not limited to, 0.005, 0.01, 0.03, 0.06, 0.08, 0.1, 0.12, 0.15, 0.18, or 0.2. For example, the pH adjuster may be, but is not limited to, aminomethyl propanol.

[0037] The content of the colorant may be, but is not limited to, 0.001 part, 0.005 part, 0.01 part, 0.03 part, 0.05 part, 0.08 part, or 0.1 part. For example, the colorant may be, but is not limited to, COSMI306.

[0038] Among them, the content of the antioxidant repair composition can be but is not limited to 1 part, 3 parts, 5 parts, 7 parts, 9 parts, 11 parts, 13 parts, 15 parts, 17 parts, 19 parts, and 20 parts.

[0039] Specifically, the preparation method of the above cosmetics comprises the following steps:

[0040] (1) Mix water, thickener, and a portion of moisturizer, heat to 80-85° C., and stir evenly;

[0041] (2) The mixture obtained in step (1) is cooled to below 40° C., and then a pH adjuster, an antioxidant repair composition, an antibacterial agent, another portion of a moisturizer, and a colorant are added in sequence, and stirred until the mixture is uniformly dissolved.

[0042] In order to better illustrate the purpose, technical solutions and beneficial effects of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0043] Specifically, the detailed information of the main raw materials used in the embodiments and comparative examples are as follows:

[0044]

[0045]

[0046] Example 1

[0047] The present embodiment provides an antioxidant repair essence, which includes, by mass, 0.25 parts of carbomer, 0.09 parts of sodium hyaluronate, 7 parts of butylene glycol, 2 parts of glycerol, 9 parts of antioxidant repair composition, 0.6 parts of 1,2-pentanediol, 0.3 parts of 1,2-hexanediol, 0.6 parts of HL-01, 0.115 parts of aminomethyl propanol, 0.06 parts of COSMI306, and 79.985 parts of water; wherein the antioxidant repair composition includes 3 parts of oat beta-glucan solution, 0.4 parts of Idebenone, 0.1 parts of collagen solution, 3 parts of dipeptide diaminobutyryl benzylamide diacetate solution, 1 part of swan neck miracle factor, 1 part of firming and anti-wrinkle peptide, and 0.5 parts of carbohydrate isomer solution.

[0048] This embodiment also provides a method for preparing an antioxidant repair essence, the steps comprising:

[0049] (1) Mix water, carbomer, sodium hyaluronate and glycerin, heat to 82° C. and stir evenly;

[0050] (2) The mixture obtained in step (1) is cooled to 36° C., and then aminomethyl propanol, oat beta-glucan solution, Idebenone, collagen solution, dipeptide diaminobutyryl benzylamide diacetate solution, swan neck miracle factor, firming anti-wrinkle peptide, carbohydrate isomer solution, 1,2-pentanediol, 1,2-hexanediol, HL-01, butanediol, and COSMI306 are added in sequence and stirred until dissolved evenly.

[0051] Example 2

[0052] The present embodiment provides an antioxidant repair essence, which includes, by mass, 0.2 parts of carbomer, 0.05 parts of sodium hyaluronate, 6 parts of butylene glycol, 3 parts of glycerol, 4.5 parts of antioxidant repair composition, 0.5 parts of 1,2-pentanediol, 0.2 parts of 1,2-hexanediol, 0.8 parts of HL-01, 0.09 parts of aminomethyl propanol, 0.05 parts of COSMI306, and 84.61 parts of water; wherein the antioxidant repair composition includes 1.1 parts of oat beta-glucan solution, 0.8 parts of Idebenone, 0.7 parts of collagen solution, 0.6 parts of dipeptide diaminobutyryl benzylamide diacetate solution, 0.5 parts of swan neck miracle factor, 0.4 parts of firming and anti-wrinkle peptide, and 0.4 parts of carbohydrate isomer solution.

[0053] This embodiment also provides a method for preparing an antioxidant repair essence, the steps comprising:

[0054] (1) Mix water, carbomer, sodium hyaluronate and glycerin, heat to 85° C. and stir evenly;

[0055] (2) The mixture obtained in step (1) is cooled to 38° C., and then aminomethyl propanol, oat beta-glucan solution, Idebenone, collagen solution, dipeptide diaminobutyryl benzylamide diacetate solution, swan neck miracle factor, firming anti-wrinkle peptide, carbohydrate isomer solution, 1,2-pentanediol, 1,2-hexanediol, HL-01, butanediol, and COSMI306 are added in sequence and stirred until dissolved evenly.

[0056] Example 3

[0057] The present embodiment provides an antioxidant repair essence, which includes, by mass, 0.3 parts of carbomer, 0.12 parts of sodium hyaluronate, 8 parts of butylene glycol, 1 part of glycerol, 13.8 parts of antioxidant repair composition, 0.7 parts of 1,2-pentanediol, 0.4 parts of 1,2-hexanediol, 0.4 parts of HL-01, 0.13 parts of aminomethyl propanol, 0.07 parts of COSMI306, and 75.08 parts of water; wherein the antioxidant repair composition includes 4 parts of oat beta-glucan solution, 0.5 parts of Idebenone, 0.3 parts of collagen solution, 4 parts of dipeptide diaminobutyryl benzylamide diacetate solution, 2 parts of swan neck miracle factor, 2 parts of firming and anti-wrinkle peptides, and 1 part of carbohydrate isomer solution.

[0058] This embodiment also provides a method for preparing an antioxidant repair essence, the steps comprising:

[0059] (1) Mix water, carbomer, sodium hyaluronate and glycerin, heat to 81° C. and stir evenly;

[0060] (2) The mixture obtained in step (1) is cooled to 32° C., and then aminomethyl propanol, oat beta-glucan solution, Idebenone, collagen solution, dipeptide diaminobutyryl benzylamide diacetate solution, swan neck miracle factor, firming anti-wrinkle peptide, carbohydrate isomer solution, 1,2-pentanediol, 1,2-hexanediol, HL-01, butanediol, and COSMI306 are added in sequence and stirred until dissolved evenly.

[0061] Comparative Example 1

[0062] Comparative Example 1 provides an antioxidant repair essence. The antioxidant repair essence of Comparative Example 1 is basically the same as Example 1, and the only difference between the two is that the antioxidant repair composition includes 0.4 parts of Idebenone, 0.1 parts of collagen solution, 3 parts of dipeptide diaminobutyryl benzylamide diacetate solution, 1 part of swan neck miracle factor, 1 part of firming and anti-wrinkle peptide, and 0.5 parts of carbohydrate isomer solution.

[0063] The preparation method of the antioxidant repair essence of Comparative Example 1 is the same as that of Example 1.

[0064] Comparative Example 2

[0065] Comparative Example 2 provides an antioxidant repair essence. The antioxidant repair essence of Comparative Example 2 is basically the same as Example 1, and the only difference between the two is that the antioxidant repair composition includes 3 parts of oat beta-glucan solution, 0.1 parts of collagen solution, 3 parts of dipeptide diaminobutyryl benzylamide diacetate solution, 1 part of swan neck miracle factor, 1 part of firming and anti-wrinkle peptide, and 0.5 parts of carbohydrate isomer solution.

[0066] The preparation method of the antioxidant repair essence of Comparative Example 2 is the same as that of Example 1.

[0067] Comparative Example 3

[0068] Comparative Example 3 provides an antioxidant repair essence. The antioxidant repair essence of Comparative Example 3 is basically the same as Example 1, and the only difference between the two is that the antioxidant repair composition includes 3 parts of oat β-glucan solution, 0.4 parts of Idebenone, 3 parts of dipeptide diaminobutyryl benzylamide diacetate solution, 1 part of swan neck miracle factor, 1 part of firming and anti-wrinkle peptide, and 0.5 parts of carbohydrate isomer solution.

[0069] The preparation method of the antioxidant repair essence of Comparative Example 3 is the same as that of Example 1.

[0070] Comparative Example 4

[0071] Comparative Example 4 provides an antioxidant repair essence. The antioxidant repair essence of Comparative Example 4 is basically the same as that of Example 1, and the only difference between the two is that the antioxidant repair composition includes 3 parts of oat beta-glucan solution, 0.4 parts of Idebenone, 0.1 parts of collagen solution, 3 parts of dipeptide diaminobutyryl benzylamide diacetate solution, 1 part of swan neck miracle factor, and 1 part of firming and anti-wrinkle peptide.

[0072] The preparation method of the antioxidant repair essence of Comparative Example 4 is the same as that of Example 1.

[0073] Comparative Example 5

[0074] Comparative Example 5 provides an antioxidant repair essence. The antioxidant repair essence of Comparative Example 5 is basically the same as Example 1, and the only difference between the two is that the antioxidant repair composition includes 3 parts of oat beta-glucan solution, 0.4 parts of Idebenone, 0.1 parts of collagen solution, 3 parts of dipeptide diaminobutyryl benzylamide diacetate solution, 1 part of firming and anti-wrinkle peptide, and 0.5 parts of carbohydrate isomer solution.

[0075] The preparation method of the antioxidant repair essence of Comparative Example 5 is the same as that of Example 1.

[0076] Comparative Example 6

[0077] Comparative Example 6 provides an antioxidant repair essence. The antioxidant repair essence of Comparative Example 6 is basically the same as Example 1, and the only difference between the two is that the antioxidant repair composition includes 3 parts of oat beta-glucan solution, 0.4 parts of Idebenone, 0.1 parts of collagen solution, 3 parts of dipeptide diaminobutyryl benzylamide diacetate solution, 1 part of swan neck miracle factor, and 0.5 parts of carbohydrate isomer solution.

[0078] The preparation method of the antioxidant repair essence of Comparative Example 6 is the same as that of Example 1.

[0079] Comparative Example 7

[0080] Comparative Example 7 provides an antioxidant repair essence. The antioxidant repair essence of Comparative Example 7 is basically the same as Example 1, and the only difference between the two is that the antioxidant repair composition includes 3 parts of oat beta-glucan solution, 0.4 parts of Idebenone, 0.1 parts of collagen solution, 1 part of swan neck miracle factor, 1 part of firming and anti-wrinkle peptide, and 0.5 parts of carbohydrate isomer solution.

[0081] The preparation method of the antioxidant repair essence of Comparative Example 7 is the same as that of Example 1.

[0082] The antioxidant properties and skin barrier repairing effects of the antioxidant repair essences of Examples 1 to 3 and Comparative Examples 1 to 7 were tested according to the following test. The test results are shown in Table 1.

[0083] Antioxidant DPPH free radical scavenging test:

[0084] Test materials: the antioxidant repair essences of Examples 1 to 3 and Comparative Examples 1 to 7.

[0085] Test method: 4 mL of a 6×10 -5 4 mL of the antioxidant repair essence prepared in Examples 1 to 3 and Comparative Examples 1 to 7 was added with 1 mol / L DPPH solution, and the mixture was fully mixed. The absorbance value was immediately measured at 518 nm and recorded as Ai. The mixture was then placed at room temperature and protected from light for 30 min, and the absorbance value was measured and recorded as Aj. Finally, the absorbance value of only adding DPPH solution was measured and recorded as Ac. The scavenging rate of DPPH free radicals was calculated according to the following formula: scavenging rate = [1-(Ai-Aj) / Ac] × 100%;

[0086] Repair skin barrier test:

[0087] Test instrument: Skin moisture loss tester Tewameter, CK, Germany.

[0088] Test principle: Based on Fick's diffusion law, two sets of temperature and humidity sensors are used to measure the near-epidermis. The water vapor pressure gradient formed by the loss of water in the stratum corneum at two different points can directly measure the amount of water dissipated through the epidermis. The TEWL value is an important indicator of the quality of the skin barrier. The larger the TEWL value of the skin, the higher the rate of water loss through the epidermis and the worse the skin barrier function.

[0089] Test samples: the antioxidant repair essences of Examples 1 to 3 and Comparative Examples 1 to 7.

[0090] Test method: 23 subjects aged between 25 and 30 were selected. The Tewameter was used to test the transepidermal water loss value TEWL of the subjects' facial skin before using the antioxidant repair essence. The subjects applied 5g of the corresponding group of antioxidant repair essence on their faces after cleansing every day for 4 consecutive weeks. The transepidermal water loss value TEWL of the facial skin after use was tested, and the transepidermal water loss value TEWL change rate (%) of the skin was calculated. The greater the transepidermal water loss value TEWL change rate (%), the better the effect of repairing the skin barrier.

[0091] The stability and mildness of the antioxidant repair essences of Examples 1 to 3 were tested according to the following test method. The results are shown in Table 2.

[0092] Stability test:

[0093] Test sample: the antioxidant repair essence provided in Examples 1 to 3.

[0094] Test method: 30g of the test sample was placed in sample bottles A1-A3 respectively, and each group of sample bottles was placed in the same biochemical incubator for 1 month, and the incubation temperature was set to 45°C. 30g of the test sample was placed in sample bottles B1-B3 respectively, and each group of sample bottles was placed in the same biochemical incubator for 1 month, and the incubation temperature was set to -16°C. Each test sample slightly changed color at 45°C, and there was no color change or precipitation at -16°C, indicating that the product provided by the present invention has good heat and cold resistance stability.

[0095] Mildness test:

[0096] Test sample: the antioxidant repair essence provided in Examples 1 to 3.

[0097] Test method: The chorioallantoic membrane (CAM) is a respiratory membrane that surrounds the chicken embryo. Since the surface of the chicken embryo chorioallantoic membrane is rich in blood vessels and can be regarded as a complete organism, this test uses the characteristics of the complete, clear and transparent vascular system of the chorioallantoic membrane of the mid-stage incubated chicken embryo. A certain amount of the test substance is directly exposed to the chicken embryo chorioallantoic membrane. After the specified time, the changes in the toxic effect indicators of the chorioallantoic membrane (such as bleeding, coagulation and vascular melting) are observed, and scores are given. The mathematical average is calculated to evaluate the irritation of the test substance.

[0098] (1) Preparation of chicken embryos: Fertilized chicken embryos of varieties such as White Leghorn chicken, weighing 50g-60g, preferably SPF chicken embryos, are placed in an incubator for incubation, the temperature is controlled at 37.5°C ± 0.5°C, the relative humidity is 55%-70%, and the egg turning frequency is 3 times / h-6 times / h. On the 8th day of incubation, the eggs are checked with an egg candling device, unfertilized and inactive chicken embryos are discarded, and chicken embryos with well-developed blood vessels are selected, and the position of the air chamber is marked on the surface of the eggshell.

[0099] (2) Test process: There are at least 6 chicken embryos in each group, and negative and positive controls need to be set up for each test. The test started on the 9th day. Use dental curved forceps to carefully peel off the air chamber eggshell part, and drop a few drops of physiological saline on the surface of the eggshell membrane to fully moisten it. After pouring it out, use forceps to carefully remove the eggshell membrane to ensure that the exposed chorioallantoic membrane is intact and not damaged in any way. Take 0.3ml / 0.3g of the test substance and apply it directly to the CAM. Spread it as much as possible to ensure that the coverage area reaches at least 50%. After 3 minutes of action, gently rinse the surface of the CAM with double distilled water. The rinsing should be completed within 30s, pour out the liquid, and immediately observe the degree of change of each toxic effect under a stereomicroscope, and give a score (ES) according to the capillary bleeding, coagulation, and vascular melting.

[0100] (3) Observation results:

[0101] Bleeding: blood flows out of the blood vessels or capillaries of the CAM. No bleeding, mild bleeding, moderate bleeding, and severe bleeding are scored as 0, 1, 2, and 3 points, respectively.

[0102] Coagulation: refers to the denaturation of proteins inside and outside blood vessels, manifested as thrombus, swelling of the vessel wall, the appearance of coagulation points inside and outside blood vessels, milky turbidity outside blood vessels, etc. No coagulation, mild coagulation, moderate coagulation, and severe coagulation are scored as 0, 1, 2, and 3 points respectively.

[0103] Vascular ablation: refers to the ablation of blood vessels on the CAM membrane. No vascular ablation, mild vascular ablation, moderate vascular ablation, and severe vascular ablation were scored as 0, 1, 2, and 3 points, respectively.

[0104] (4) Result calculation and evaluation

[0105] Calculate the average ES score according to the following formula. If ES ≤ 12, it indicates no / mild irritation; if 12 < ES < 16, it indicates moderate irritation; if ES ≥ 16, it indicates severe irritation.

[0106]

[0107] Table 1 Test Results of Antioxidant Property and Skin Barrier Repair

[0108]

[0109] Table 2 Stability and Mildness Tests

[0110]

[0111] As can be seen from Table 1, the antioxidant repair composition of the present invention can achieve good antioxidant and skin repair effects. This is because the present invention specifically selects seven substances, namely oat β-glucan solution, Idebenone, collagen solution, dipeptide diamino butyryl benzylamide diacetate solution, swan neck miracle factor, anti-wrinkle and firming peptide, and carbohydrate isomer solution, as raw materials. Through multiple action mechanisms, it can achieve strong antioxidant and skin repair effects.

[0112] As can be seen from Table 2, the antioxidant repair essence of the present invention has good stability and mildness.

[0113] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit the protection scope of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently replaced without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. An antioxidant repair composition, characterized in that: The invention comprises, by mass, 0.1 to 10 parts of oat beta-glucan solution, 0.01 to 2 parts of Idebenone, 0.01 to 10 parts of collagen solution, 0.1 to 10 parts of dipeptide diaminobutyryl benzylamide diacetate solution, 0.01 to 10 parts of swan neck miracle factor, 0.01 to 10 parts of firming and anti-wrinkle peptide, and 0.01 to 5 parts of carbohydrate isomer solution; the Idebenone is a mixture containing hydroxydecyl ubiquinone; the collagen solution is a mixed solution containing hydrolyzed collagen; the swan neck miracle factor is a mixed solution containing gourd extract, lactic acid bacteria fermentation extract and lactobacillus / black mustard seed fermentation product extract; the firming and anti-wrinkle peptide is a mixed solution containing sweet almond seed extract and hydrolyzed rice protein.

2. The antioxidant repair composition according to claim 1, characterized in that: The oat beta glucan solution is a mixed solution consisting of water, glycerol and oat beta glucan in a mass ratio of 70-80:10-20:1.2-1.

6.

3. The antioxidant repair composition according to claim 1, characterized in that: The idebenone is a mixture of hydroxydecylubiquinone, polysorbate-80, polyethylene glycol-8 and caprylic / capric triglyceride in a mass ratio of 9-11:52-56:15-20:15-20.

4. The antioxidant repair composition according to claim 1, characterized in that: The collagen solution is a mixed solution consisting of hydrolyzed collagen, water and butanediol in a mass ratio of 0.8-1.2:67-71:27-32.

5. The antioxidant repair composition according to claim 1, characterized in that: The dipeptide diaminobutyryl benzylamide diacetate solution is a mixed solution consisting of water, glycerol and dipeptide diaminobutyryl benzylamide diacetate in a mass ratio of 70-80:20-30:0.09-0.

12.

6. The antioxidant repair composition according to claim 1, characterized in that: The swan neck miracle factor is a mixture of water, 1,3-propylene glycol, glycerin, cucurbita serrata extract, lactic acid bacteria fermentation extract and lactobacillus / black mustard seed fermentation product extract in a mass ratio of 30-50:20-40:20-40:2-4:0.975-1.625:0.525-0.

875.

7. The antioxidant repair composition according to claim 1, characterized in that: The firming and anti-wrinkle peptide is a mixed solution consisting of water, sweet almond seed extract and hydrolyzed rice protein in a mass ratio of 88-92:5.8-6.8:3-3.

5.

8. The antioxidant repair composition according to claim 1, characterized in that: The saccharide isomer solution is a mixed solution consisting of saccharide isomers and water in a mass ratio of 50-70:25-50.

9. A cosmetic, characterized in that: It comprises a cosmetic external dosage form matrix and also comprises the antioxidant repair composition according to any one of claims 1 to 8.

10. The cosmetic according to claim 9, characterized in that The cosmetic external dosage form matrix is ​​selected from at least one of a thickener, a moisturizer, an antibacterial agent, a pH regulator and a colorant.

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