Oseltamivir phosphate granules and preparation method thereof

Abstract

The invention discloses oseltamivir phosphate particles and a preparation method thereof, and particularly relates to the technical field of oseltamivir particle preparation, and the preparation method comprises the following steps: raw material preparation, raw material mixing, soft material preparation, drying and grinding, whole particle sieving, and filling and sub-packaging. The oseltamivir phosphate adopting erythritol, starch slurry and water as a diluent, an adhesive and a solvent can generate relatively low heat in a body, meanwhile, the starch slurry is dissolved in water, so that the preparation cost of the oseltamivir phosphate is reduced, the starch slurry can be decomposed into glucose in the body after being taken, the glucose is absorbed into blood circulation, and the blood circulation is promoted. The oseltamivir phosphate granules have the advantages that the oseltamivir phosphate granules prepared by the aid of the method are low in toxicity and low in harm to human bodies, the oseltamivir phosphate granules are dried at the temperature of 60 DEG C for 7.5 hours when the oseltamivir phosphate granules are dried after the oseltamivir phosphate granules are prepared, accordingly, the water content of the oseltamivir phosphate granules can be reduced, the oseltamivir phosphate granules can be conveniently crushed into powder, the brown scorch rate of the oseltamivir phosphate granules can be reduced, and the yield of the

Description

Technical Field

[0001] The present invention relates to the technical field of oseltamivir granule preparation, and more specifically, to oseltamivir phosphate granules and a preparation method thereof. Background Art

[0002] Oseltamivir phosphate granules are an antiviral drug used to treat and prevent influenza A and B. It specifically inhibits the neuraminidase activity of influenza viruses, preventing the release of viruses from infected cells, thereby reducing the spread of viruses in the body. It is suitable for the treatment of influenza A and B in adults and children aged 1 year and above, and for the prevention of influenza A and B in adults and adolescents aged 13 years and above. The dosage varies depending on the patient's physical condition.

[0003] After taking the existing oseltamivir phosphate granules, maltitol, povidone and ethanol are generally used to produce oseltamivir phosphate. After taking the oseltamivir phosphate granules containing maltitol, povidone and ethanol, maltitol is not easily digested and absorbed by the human body and will accumulate in the body and be converted into fat. At the same time, some people have an allergic reaction to povidone, which will cause harm to the human body. At the same time, ethanol will cause damage to human organs. Therefore, improvements are needed. Summary of the invention

[0004] In order to overcome the above defects, the present invention provides an oseltamivir phosphate granule and a preparation method thereof. The technical problem to be solved by the present invention is that after taking the existing oseltamivir phosphate granules, maltitol, povidone and ethanol are generally used to produce oseltamivir phosphate. After taking the oseltamivir phosphate granules containing maltitol, povidone and ethanol, maltitol is not easily digested and absorbed by the human body and will accumulate in the body and be converted into fat. At the same time, some people have an allergic reaction to povidone, which will cause harm to the human body, and ethanol will cause damage to human organs.

[0005] To achieve the above object, the present invention provides the following technical solution: an oseltamivir phosphate granule, comprising oseltamivir phosphate, a diluent and a binder, wherein the weights of oseltamivir phosphate, the diluent and the binder are 10 g of oseltamivir phosphate, 200 g of the diluent and 50 g of the binder, respectively.

[0006] A method for preparing oseltamivir phosphate granules, the preparation method comprising the following steps:

[0007] Raw material preparation: weigh and prepare oseltamivir phosphate, diluent and binder, and grind oseltamivir phosphate, diluent and binder into powder;

[0008] Mixing raw materials: pour the crushed and ground oseltamivir phosphate and diluent into a blender for mixing;

[0009] Preparation of soft material: pour the binder into the solvent and stir to form a binder solution, then pour the binder solution into the mixture of oseltamivir phosphate and diluent powder and sieve to granulate;

[0010] Dry grinding: The wet particles are placed to dry, and then the dried particles are crushed and ground;

[0011] Whole grain screening: Screen the powder particles after drying and grinding, and remove the larger particles;

[0012] Filling and packaging: The sieved powder particles are packaged according to a certain weight

[0013] As a further embodiment of the present invention: the diluent is one of maltitol and erythritol.

[0014] As a further solution of the present invention: the binder used in the preparation of the soft material is one of polyvidone or starch slurry, and the solvent used in the preparation of the soft material is one of water or ethanol.

[0015] As a further solution of the present invention: during the preparation of the soft material, a binder, oseltamivir phosphate and a diluent are mixed in a box, and sweeteners and edible flavor powder are added to the mixture.

[0016] As a further solution of the present invention: the drying temperature during the drying and grinding process is between 50° C. and 80° C., and the drying time is between 7 and 8 hours.

[0017] As a further solution of the present invention: the sieve used for sieving the whole particles is a 50-mesh sieve.

[0018] The beneficial effects of the present invention are as follows: by taking the prepared oseltamivir phosphate granules, since erythritol, starch slurry and water are used as diluents, adhesives and solvents for preparing the oseltamivir phosphate granules, lower heat is generated in the body, and the starch slurry is dissolved in water, which reduces the cost of preparing the oseltamivir phosphate, and the starch slurry is decomposed into glucose in the body after taking it and absorbed into the blood circulation, which causes less harm to the human body. At the same time, when drying is performed after the preparation, the oseltamivir phosphate granules are placed at 60° C. for drying for 7.5 hours, so that the water content in the oseltamivir phosphate granules is reduced, the oseltamivir phosphate granules are crushed into powder conveniently, the browning rate of the oseltamivir phosphate granules is reduced, and the yield rate of the oseltamivir phosphate granules is improved. DETAILED DESCRIPTION

[0019] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0020] Embodiment 1:

[0021] An oseltamivir phosphate granule, comprising oseltamivir phosphate, a diluent and a binder, wherein the weights of the oseltamivir phosphate, the diluent and the binder are 10 g of oseltamivir phosphate, 200 g of the diluent and 50 g of the binder, respectively;

[0022] The preparation method of oseltamivir phosphate granules comprises the following steps:

[0023] Raw material preparation: weigh and prepare oseltamivir phosphate, diluent and binder, and grind oseltamivir phosphate, diluent and binder into powder;

[0024] Mixing raw materials: pour the crushed and ground oseltamivir phosphate and diluent into a blender for mixing;

[0025] Preparation of soft material: pour the binder into the solvent and stir to form a binder solution, then pour the binder solution into the mixture of oseltamivir phosphate and diluent powder and sieve to granulate;

[0026] Dry grinding: The wet particles are placed to dry, and then the dried particles are crushed and ground;

[0027] Whole grain screening: Screen the powder particles after drying and grinding, and remove the larger particles;

[0028] Filling and packaging: The sieved powder particles are packaged according to a certain weight.

[0029] The diluent is maltitol.

[0030] The binder used in the preparation of the soft material is povidone, and the solvent used in the preparation of the soft material is water.

[0031] During the preparation of the soft material, a binder, oseltamivir phosphate and a diluent are mixed in a box, and sweeteners and edible flavor powder are added to the mixture to adjust the taste of the mixture.

[0032] The drying temperature during the drying and grinding process is between 50°C and 80°C, and the drying time is between 7 and 8 hours.

[0033] The sieve used for sieving the whole grains is a 50-mesh sieve.

[0034] Embodiment 2:

[0035] An oseltamivir phosphate granule, comprising oseltamivir phosphate, a diluent and a binder, wherein the weights of the oseltamivir phosphate, the diluent and the binder are 10 g of oseltamivir phosphate, 200 g of the diluent and 50 g of the binder, respectively;

[0036] The preparation method of oseltamivir phosphate granules comprises the following steps:

[0037] Raw material preparation: weigh and prepare oseltamivir phosphate, diluent and binder, and grind oseltamivir phosphate, diluent and binder into powder;

[0038] Mixing raw materials: pour the crushed and ground oseltamivir phosphate and diluent into a blender for mixing;

[0039] Preparation of soft material: pour the binder into the solvent and stir to form a binder solution, then pour the binder solution into the mixture of oseltamivir phosphate and diluent powder and sieve to granulate;

[0040] Dry grinding: The wet particles are placed to dry, and then the dried particles are crushed and ground;

[0041] Whole grain screening: Screen the powder particles after drying and grinding, and remove the larger particles;

[0042] Filling and packaging: The sieved powder particles are packaged according to a certain weight.

[0043] The diluent is erythritol.

[0044] The binder used in the preparation of the soft material is povidone, and the solvent used in the preparation of the soft material is water.

[0045] During the preparation of the soft material, a binder, oseltamivir phosphate and a diluent are mixed in a box, and sweeteners and edible flavor powder are added to the mixture to adjust the taste of the mixture.

[0046] The drying temperature during the drying and grinding process is between 50°C and 80°C, and the drying time is between 7 and 8 hours.

[0047] The sieve used for sieving the whole grains is a 50-mesh sieve.

[0048] Embodiment 3:

[0049] An oseltamivir phosphate granule, comprising oseltamivir phosphate, a diluent and a binder, wherein the weights of the oseltamivir phosphate, the diluent and the binder are 10 g of oseltamivir phosphate, 200 g of the diluent and 50 g of the binder, respectively;

[0050] The preparation method of oseltamivir phosphate granules comprises the following steps:

[0051] Raw material preparation: weigh and prepare oseltamivir phosphate, diluent and binder, and grind oseltamivir phosphate, diluent and binder into powder;

[0052] Mixing raw materials: pour the crushed and ground oseltamivir phosphate and diluent into a blender for mixing;

[0053] Preparation of soft material: pour the binder into the solvent and stir to form a binder solution, then pour the binder solution into the mixture of oseltamivir phosphate and diluent powder and sieve to granulate;

[0054] Dry grinding: The wet particles are placed to dry, and then the dried particles are crushed and ground;

[0055] Whole grain screening: Screen the powder particles after drying and grinding, and remove the larger particles;

[0056] Filling and packaging: The sieved powder particles are packaged according to a certain weight.

[0057] The diluent is maltitol.

[0058] The adhesive in the preparation of soft materials is starch slurry, and the solvent used in the preparation of soft materials is water.

[0059] During the preparation of the soft material, a binder, oseltamivir phosphate and a diluent are mixed in a box, and sweeteners and edible flavor powder are added to the mixture to adjust the taste of the mixture.

[0060] The drying temperature during the drying and grinding process is between 50°C and 80°C, and the drying time is between 7 and 8 hours.

[0061] The sieve used for sieving the whole grains is a 50-mesh sieve.

[0062] Embodiment 4:

[0063] An oseltamivir phosphate granule, comprising oseltamivir phosphate, a diluent and a binder, wherein the weights of the oseltamivir phosphate, the diluent and the binder are 10 g of oseltamivir phosphate, 200 g of the diluent and 50 g of the binder, respectively;

[0064] The preparation method of oseltamivir phosphate granules comprises the following steps:

[0065] Raw material preparation: weigh and prepare oseltamivir phosphate, diluent and binder, and grind oseltamivir phosphate, diluent and binder into powder;

[0066] Mixing raw materials: pour the crushed and ground oseltamivir phosphate and diluent into a blender for mixing;

[0067] Preparation of soft material: pour the binder into the solvent and stir to form a binder solution, then pour the binder solution into the mixture of oseltamivir phosphate and diluent powder and sieve to granulate;

[0068] Dry grinding: The wet particles are placed to dry, and then the dried particles are crushed and ground;

[0069] Whole grain screening: Screen the powder particles after drying and grinding, and remove the larger particles;

[0070] Filling and packaging: The sieved powder particles are packaged according to a certain weight.

[0071] The diluent is erythritol.

[0072] The adhesive in the preparation of soft materials is starch slurry, and the solvent used in the preparation of soft materials is water.

[0073] During the preparation of the soft material, a binder, oseltamivir phosphate and a diluent are mixed in a box, and sweeteners and edible flavor powder are added to the mixture to adjust the taste of the mixture.

[0074] The drying temperature during the drying and grinding process is between 50°C and 80°C, and the drying time is between 7 and 8 hours.

[0075] The sieve used for sieving the whole grains is a 50-mesh sieve.

[0076] Embodiment 5:

[0077] An oseltamivir phosphate granule, comprising oseltamivir phosphate, a diluent and a binder, wherein the weights of the oseltamivir phosphate, the diluent and the binder are 10 g of oseltamivir phosphate, 200 g of the diluent and 50 g of the binder, respectively;

[0078] The preparation method of oseltamivir phosphate granules comprises the following steps:

[0079] Raw material preparation: weigh and prepare oseltamivir phosphate, diluent and binder, and grind oseltamivir phosphate, diluent and binder into powder;

[0080] Mixing raw materials: pour the crushed and ground oseltamivir phosphate and diluent into a blender for mixing;

[0081] Preparation of soft material: pour the binder into the solvent and stir to form a binder solution, then pour the binder solution into the mixture of oseltamivir phosphate and diluent powder and sieve to granulate;

[0082] Dry grinding: The wet particles are placed to dry, and then the dried particles are crushed and ground;

[0083] Whole grain screening: Screen the powder particles after drying and grinding, and remove the larger particles;

[0084] Filling and packaging: The sieved powder particles are packaged according to a certain weight.

[0085] The diluent is maltitol.

[0086] The adhesive used in the preparation of the soft material is povidone, and the solvent used in the preparation of the soft material is ethanol.

[0087] During the preparation of the soft material, a binder, oseltamivir phosphate and a diluent are mixed in a box, and sweeteners and edible flavor powder are added to the mixture to adjust the taste of the mixture.

[0088] The drying temperature during the drying and grinding process is between 50°C and 80°C, and the drying time is between 7 and 8 hours.

[0089] The sieve used for sieving the whole grains is a 50-mesh sieve.

[0090] Embodiment 6:

[0091] An oseltamivir phosphate granule, comprising oseltamivir phosphate, a diluent and a binder, wherein the weights of the oseltamivir phosphate, the diluent and the binder are 10 g of oseltamivir phosphate, 200 g of the diluent and 50 g of the binder, respectively;

[0092] The preparation method of oseltamivir phosphate granules comprises the following steps:

[0093] Raw material preparation: weigh and prepare oseltamivir phosphate, diluent and binder, and grind oseltamivir phosphate, diluent and binder into powder;

[0094] Mixing raw materials: pour the crushed and ground oseltamivir phosphate and diluent into a blender for mixing;

[0095] Preparation of soft material: pour the binder into the solvent and stir to form a binder solution, then pour the binder solution into the mixture of oseltamivir phosphate and diluent powder and sieve to granulate;

[0096] Dry grinding: The wet particles are placed to dry, and then the dried particles are crushed and ground;

[0097] Whole grain screening: Screen the powder particles after drying and grinding, and remove the larger particles;

[0098] Filling and packaging: The sieved powder particles are packaged according to a certain weight.

[0099] The diluent is erythritol.

[0100] The adhesive used in the preparation of the soft material is povidone, and the solvent used in the preparation of the soft material is ethanol.

[0101] During the preparation of the soft material, a binder, oseltamivir phosphate and a diluent are mixed in a box, and sweeteners and edible flavor powder are added to the mixture to adjust the taste of the mixture.

[0102] The drying temperature during the drying and grinding process is between 50°C and 80°C, and the drying time is between 7 and 8 hours.

[0103] The sieve used for sieving the whole grains is a 50-mesh sieve.

[0104] Embodiment 7:

[0105] An oseltamivir phosphate granule, comprising oseltamivir phosphate, a diluent and a binder, wherein the weights of the oseltamivir phosphate, the diluent and the binder are 10 g of oseltamivir phosphate, 200 g of the diluent and 50 g of the binder, respectively;

[0106] The preparation method of oseltamivir phosphate granules comprises the following steps:

[0107] Raw material preparation: weigh and prepare oseltamivir phosphate, diluent and binder, and grind oseltamivir phosphate, diluent and binder into powder;

[0108] Mixing raw materials: pour the crushed and ground oseltamivir phosphate and diluent into a blender for mixing;

[0109] Preparation of soft material: pour the binder into the solvent and stir to form a binder solution, then pour the binder solution into the mixture of oseltamivir phosphate and diluent powder and sieve to granulate;

[0110] Dry grinding: The wet particles are placed to dry, and then the dried particles are crushed and ground;

[0111] Whole grain screening: Screen the powder particles after drying and grinding, and remove the larger particles;

[0112] Filling and packaging: The sieved powder particles are packaged according to a certain weight.

[0113] The diluent is maltitol.

[0114] The adhesive used in the preparation of the soft material is starch slurry, and the solvent used in the preparation of the soft material is ethanol.

[0115] During the preparation of the soft material, a binder, oseltamivir phosphate and a diluent are mixed in a box, and sweeteners and edible flavor powder are added to the mixture to adjust the taste of the mixture.

[0116] The drying temperature during the drying and grinding process is between 50°C and 80°C, and the drying time is between 7 and 8 hours.

[0117] The sieve used for sieving the whole grains is a 50-mesh sieve.

[0118] Embodiment 8:

[0119] An oseltamivir phosphate granule, comprising oseltamivir phosphate, a diluent and a binder, wherein the weights of the oseltamivir phosphate, the diluent and the binder are 10 g of oseltamivir phosphate, 200 g of the diluent and 50 g of the binder, respectively;

[0120] The preparation method of oseltamivir phosphate granules comprises the following steps:

[0121] Raw material preparation: weigh and prepare oseltamivir phosphate, diluent and binder, and grind oseltamivir phosphate, diluent and binder into powder;

[0122] Mixing raw materials: pour the crushed and ground oseltamivir phosphate and diluent into a blender for mixing;

[0123] Preparation of soft material: pour the binder into the solvent and stir to form a binder solution, then pour the binder solution into the mixture of oseltamivir phosphate and diluent powder and sieve to granulate;

[0124] Dry grinding: The wet particles are placed to dry, and then the dried particles are crushed and ground;

[0125] Whole grain screening: Screen the powder particles after drying and grinding, and remove the larger particles;

[0126] Filling and packaging: The sieved powder particles are packaged according to a certain weight.

[0127] The diluent is erythritol.

[0128] The adhesive used in the preparation of the soft material is starch slurry, and the solvent used in the preparation of the soft material is ethanol.

[0129] During the preparation of the soft material, a binder, oseltamivir phosphate and a diluent are mixed in a box, and sweeteners and edible flavor powder are added to the mixture to adjust the taste of the mixture.

[0130] The drying temperature during the drying and grinding process is between 50°C and 80°C, and the drying time is between 7 and 8 hours.

[0131] The sieve used for sieving the whole grains is a 50-mesh sieve.

[0132] The following table is obtained based on Examples 1-8:

[0133]

[0134] Embodiment 9:

[0135] An oseltamivir phosphate granule, comprising oseltamivir phosphate, a diluent and a binder, wherein the weights of the oseltamivir phosphate, the diluent and the binder are 10 g of oseltamivir phosphate, 200 g of the diluent and 50 g of the binder, respectively;

[0136] The preparation method of oseltamivir phosphate granules comprises the following steps:

[0137] Raw material preparation: weigh and prepare oseltamivir phosphate, diluent and binder, and grind oseltamivir phosphate, diluent and binder into powder;

[0138] Mixing raw materials: pour the crushed and ground oseltamivir phosphate and diluent into a blender for mixing;

[0139] Preparation of soft material: pour the binder into the solvent and stir to form a binder solution, then pour the binder solution into the mixture of oseltamivir phosphate and diluent powder and sieve to granulate;

[0140] Dry grinding: The wet particles are placed to dry, and then the dried particles are crushed and ground;

[0141] Whole grain screening: Screen the powder particles after drying and grinding, and remove the larger particles;

[0142] Filling and packaging: The sieved powder particles are packaged according to a certain weight.

[0143] The diluent is erythritol.

[0144] The adhesive in the preparation of soft materials is starch slurry, and the solvent used in the preparation of soft materials is water.

[0145] During the preparation of the soft material, a binder, oseltamivir phosphate and a diluent are mixed in a box, and sweeteners and edible flavor powder are added to the mixture to adjust the taste of the mixture.

[0146] The drying temperature during the drying and grinding process is 50°C and the drying time is between 7 and 8 hours.

[0147] The sieve used for sieving the whole grains is a 50-mesh sieve.

[0148] Embodiment 10:

[0149] An oseltamivir phosphate granule, comprising oseltamivir phosphate, a diluent and a binder, wherein the weights of the oseltamivir phosphate, the diluent and the binder are 10 g of oseltamivir phosphate, 200 g of the diluent and 50 g of the binder, respectively;

[0150] The preparation method of oseltamivir phosphate granules comprises the following steps:

[0151] Raw material preparation: weigh and prepare oseltamivir phosphate, diluent and binder, and grind oseltamivir phosphate, diluent and binder into powder;

[0152] Mixing raw materials: pour the crushed and ground oseltamivir phosphate and diluent into a blender for mixing;

[0153] Preparation of soft material: pour the binder into the solvent and stir to form a binder solution, then pour the binder solution into the mixture of oseltamivir phosphate and diluent powder and sieve to granulate;

[0154] Dry grinding: The wet particles are placed to dry, and then the dried particles are crushed and ground;

[0155] Whole grain screening: Screen the powder particles after drying and grinding, and remove the larger particles;

[0156] Filling and packaging: The sieved powder particles are packaged according to a certain weight.

[0157] The diluent is erythritol.

[0158] The adhesive in the preparation of soft materials is starch slurry, and the solvent used in the preparation of soft materials is water.

[0159] During the preparation of the soft material, a binder, oseltamivir phosphate and a diluent are mixed in a box, and sweeteners and edible flavor powder are added to the mixture to adjust the taste of the mixture.

[0160] The drying temperature during the drying and grinding process is 60°C and the drying time is between 7 and 8 hours.

[0161] The sieve used for sieving the whole grains is a 50-mesh sieve.

[0162] Embodiment 11:

[0163] An oseltamivir phosphate granule, comprising oseltamivir phosphate, a diluent and a binder, wherein the weights of the oseltamivir phosphate, the diluent and the binder are 10 g of oseltamivir phosphate, 200 g of the diluent and 50 g of the binder, respectively;

[0164] The preparation method of oseltamivir phosphate granules comprises the following steps:

[0165] Raw material preparation: weigh and prepare oseltamivir phosphate, diluent and binder, and grind oseltamivir phosphate, diluent and binder into powder;

[0166] Mixing raw materials: pour the crushed and ground oseltamivir phosphate and diluent into a blender for mixing;

[0167] Preparation of soft material: pour the binder into the solvent and stir to form a binder solution, then pour the binder solution into the mixture of oseltamivir phosphate and diluent powder and sieve to granulate;

[0168] Dry grinding: The wet particles are placed to dry, and then the dried particles are crushed and ground;

[0169] Whole grain screening: Screen the powder particles after drying and grinding, and remove the larger particles;

[0170] Filling and packaging: The sieved powder particles are packaged according to a certain weight.

[0171] The diluent is erythritol.

[0172] The adhesive in the preparation of soft materials is starch slurry, and the solvent used in the preparation of soft materials is water.

[0173] During the preparation of the soft material, a binder, oseltamivir phosphate and a diluent are mixed in a box, and sweeteners and edible flavor powder are added to the mixture to adjust the taste of the mixture.

[0174] The drying temperature during the drying and grinding process is 70°C and the drying time is between 7 and 8 hours.

[0175] The sieve used for sieving the whole grains is a 50-mesh sieve.

[0176] Embodiment 12:

[0177] An oseltamivir phosphate granule, comprising oseltamivir phosphate, a diluent and a binder, wherein the weights of the oseltamivir phosphate, the diluent and the binder are 10 g of oseltamivir phosphate, 200 g of the diluent and 50 g of the binder, respectively;

[0178] The preparation method of oseltamivir phosphate granules comprises the following steps:

[0179] Raw material preparation: weigh and prepare oseltamivir phosphate, diluent and binder, and grind oseltamivir phosphate, diluent and binder into powder;

[0180] Mixing raw materials: pour the crushed and ground oseltamivir phosphate and diluent into a blender for mixing;

[0181] Preparation of soft material: pour the binder into the solvent and stir to form a binder solution, then pour the binder solution into the mixture of oseltamivir phosphate and diluent powder and sieve to granulate;

[0182] Dry grinding: The wet particles are placed to dry, and then the dried particles are crushed and ground;

[0183] Whole grain screening: Screen the powder particles after drying and grinding, and remove the larger particles;

[0184] Filling and packaging: The sieved powder particles are packaged according to a certain weight.

[0185] The diluent is erythritol.

[0186] The adhesive in the preparation of soft materials is starch slurry, and the solvent used in the preparation of soft materials is water.

[0187] During the preparation of the soft material, a binder, oseltamivir phosphate and a diluent are mixed in a box, and sweeteners and edible flavor powder are added to the mixture to adjust the taste of the mixture.

[0188] The drying temperature during the drying and grinding process is 80°C and the drying time is between 7 and 8 hours.

[0189] The sieve used for sieving the whole grains is a 50-mesh sieve.

[0190] The following table is obtained based on Examples 9-12:

[0191]

[0192] From the comparison in the above table, we can see that:

[0193] It can be seen from Examples 1-8 that starch slurry has a higher solubility in water as a binder, and has a higher cost-effectiveness than polyvidone dissolved in water or ethanol. At the same time, the number of people who are allergic to starch slurry is smaller than that of polyvidone, which can reduce the possibility of allergy to the prepared oseltamivir phosphate particles. Starch slurry is mixed into water as a binder and poured into erythritol as a raw material for the preparation of oseltamivir phosphate. The heat generated after the medicine is taken is small, and the starch slurry will be decomposed into glucose in the body after taking it, and then absorbed into the blood circulation, which is less harmful to the human body. At the same time, water as a solvent is less harmful to the human body than ethanol.

[0194] It is known from Examples 9-12 that when drying the mixture of oseltamivir phosphate and diluent powder, the temperature is adjusted to 60° C. and baked for 7.5 hours, the moisture content in the mixture can be greatly reduced, and the browning rate of the mixture is low, thereby improving the yield.

[0195] Finally, a few points should be explained: Although the present invention has been described in detail above with general descriptions and specific embodiments, on the basis of the present invention, the above embodiments are only used to illustrate the technical solution of the present invention, rather than to limit it; although the present invention has been described in detail with reference to the aforementioned embodiments, ordinary technicians in this field should understand that they can still modify the technical solutions recorded in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. An oseltamivir phosphate granule, characterized in that: The oseltamivir phosphate particles include oseltamivir phosphate, a diluent and a binder, wherein the weights of the oseltamivir phosphate, the diluent and the binder are 10 g of oseltamivir phosphate, 200 g of the diluent and 50 g of the binder, respectively.

2. A method for preparing oseltamivir phosphate granules, according to the oseltamivir phosphate granules according to claim 1, characterized in that: The preparation method comprises the following steps: Raw material preparation: weigh and prepare oseltamivir phosphate, diluent and binder, and grind oseltamivir phosphate, diluent and binder into powder; Mixing raw materials: pour the crushed and ground oseltamivir phosphate and diluent into a blender for mixing; Preparation of soft material: pour the binder into the solvent and stir to form a binder solution, then pour the binder solution into the mixture of oseltamivir phosphate and diluent powder and sieve to granulate; Dry grinding: The wet particles are placed to dry, and then the dried particles are crushed and ground; Whole grain screening: Screen the powder particles after drying and grinding, and remove the larger particles; Filling and packaging: The sieved powder particles are packaged according to a certain weight.

3. The oseltamivir phosphate granules according to claim 1, characterized in that: The diluent is one of maltitol and erythritol.

4. The method for preparing oseltamivir phosphate granules according to claim 2, characterized in that: The adhesive used in the preparation of the soft material is one of polyvidone or starch slurry, and the solvent used in the preparation of the soft material is one of water or ethanol.

5. The method for preparing oseltamivir phosphate granules according to claim 2, characterized in that: During the preparation of the soft material, a binder, oseltamivir phosphate and a diluent are mixed in a box, and a sweetener and edible flavor powder are added to the mixture.

6. The method for preparing oseltamivir phosphate granules according to claim 2, characterized in that: The drying temperature during the drying and grinding process is between 50° C. and 80° C., and the drying time is between 7 and 8 hours.

7. The method for preparing oseltamivir phosphate granules according to claim 2, characterized in that: The sieve used for sieving the whole grains is a 50-mesh sieve.

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