Traditional Chinese medicine composition for treating scalds as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating scalds and a preparation method and application thereof. The traditional Chinese medicine composition for treating scalds is prepared from the following components: 10 to 15 parts of radix et rhizoma rhei, 10 to 15 parts of radix sanguisorbae, 10 to 20 parts of radix angelicae sinensis, 5 to 10 parts of rhizoma coptidis, 5 to 10 parts of cortex phellodendri, 10 to 20 parts of fructus gardeniae, 5 to 10 parts of rhizoma polygoni cuspidati, 5 to 10 parts of elm bark inner layer, 5 to 10 parts of herba portulacae, 5 to 10 parts of flos lonicerae, 2 to 5 parts of borneol, 0.1 to 0.5 part of preservative, 1 to 3 parts of humectant and 0.5 to 2 parts of thickening agent. By adopting the combination of multiple Chinese herbal medicines such as rheum officinale, raw sanguisorba officinalis, angelica sinensis, coptis chinensis, golden cypress, cape jasmine, polygonum cuspidatum, elm bark inner layer, purslane and honeysuckle, the synergistic effect of the traditional Chinese medicines is fully utilized, and the remarkable technical effects of clearing away heat and toxic materials, relieving swelling and pain and promoting wound healing are achieved. Compared with the technical scheme of single Chinese herbal medicine or simple mixing in the prior art, the medicine composition has the advantages that the comprehensiveness and the treatment effect of the medicine effect are remarkably improved, and the healing speed of scalds is increased.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and specifically to a traditional Chinese medicine composition for treating scalds, and a preparation method and application thereof. Background Art

[0002] Burns are one of the common accidental injuries in daily life. Severe burns not only cause severe pain, but may also lead to infection, scar formation, and even permanent damage. In order to alleviate the pain caused by burns and promote wound healing, a variety of burn treatment solutions have appeared on the market. However, the existing technology still has many deficiencies in terms of comprehensive efficacy, user experience, and preparation process.

[0003] Insufficient comprehensive efficacy: Many existing burn syrups use a single Chinese herbal ingredient or a simple Chinese herbal mixture formula, which often cannot provide comprehensive therapeutic effects. Since a single or simple combination of Chinese herbal medicines is difficult to achieve the synergistic effect of multiple therapeutic effects, the efficacy is not comprehensive, the treatment effect is not significant, the healing speed is slow, and the patient's recovery process is affected.

[0004] Poor user experience: Some existing burn medicines cannot effectively keep the skin moist, which can easily cause the burned area to become dry and tight, increase the patient's discomfort, and thus affect the efficacy of the medicine and the convenience of use. These problems not only reduce the patient's user experience, but may also affect the compliance and overall effect of the treatment.

[0005] Limitations of the preparation process: Traditional methods for preparing scald syrups mostly use normal pressure boiling and concentration and simple stirring methods. These methods are prone to volatilization and decomposition of the active ingredients in the syrup during high-temperature boiling, thereby reducing the efficacy. At the same time, simple stirring cannot ensure the uniformity of the syrup, which can easily cause uneven distribution of ingredients and affect the consistency and stability of the efficacy. The limitations of this preparation process significantly affect the efficiency and quality of the syrup, making it difficult to achieve the best effect in treatment.

[0006] In view of this, the present invention is proposed. Summary of the invention

[0007] The purpose of the present invention is to provide a Chinese medicine composition for treating scalds, and a preparation method and application thereof; the Chinese medicine composition, under the synergistic effect of various components, achieves the remarkable technical effects of clearing away heat and detoxifying, reducing swelling and relieving pain, and promoting wound healing; compared with the technical solutions of using a single Chinese herbal medicine or a simple mixture in the prior art, the present invention solves the problems of incomplete efficacy and slow healing speed, and provides a more effective scald treatment solution.

[0008] In order to overcome the deficiencies of the prior art, the present invention provides the following technical solutions:

[0009] A Chinese medicine composition for treating scalds comprises the following components by weight: 10-15 parts of rhubarb, 10-15 parts of raw sanguisorba officinalis, 10-20 parts of angelica sinensis, 5-10 parts of coptis chinensis, 5-10 parts of phellodendron amurense, 10-20 parts of gardenia jasminoides, 5-10 parts of knotweed, 5-10 parts of inner layer of elm bark, 5-10 parts of purslane, 5-10 parts of honeysuckle, 2-5 parts of borneol, 0.1-0.5 parts of preservatives, 1-3 parts of moisturizers and 0.5-2 parts of thickeners.

[0010] Preferably, a traditional Chinese medicine composition for treating burns comprises the following components, by weight: 14 parts of rhubarb, 14 parts of raw sanguisorba officinalis, 20 parts of angelica sinensis, 7 parts of coptis chinensis, 7 parts of phellodendron chinense, 20 parts of gardenia jasminoides, 7 parts of knotweed, 7 parts of inner layer of elm bark, 7 parts of purslane, 7 parts of honeysuckle, 5 parts of borneol, 0.4 parts of preservatives, 3 parts of humectants, and 1 part of thickener.

[0011] Preferably, the preservative is selected from one or a combination of the following: sodium benzoate, benzoic acid, potassium sorbate, methylparaben, ethylparaben;

[0012] And / or, the moisturizing agent is selected from one or a combination of the following: glycerin, propylene glycol, butylene glycol, sodium hyaluronate;

[0013] And / or, the thickener is selected from one of the following or a combination thereof: xanthan gum, sodium carboxymethyl cellulose, guar gum, sodium alginate.

[0014] Preferably, the auxiliary material comprises one or a combination of the following ingredients: vitamin E, aloe extract, tea polyphenols, allantoin;

[0015] And / or, the amount of the auxiliary material is 0.1-1% of the total weight of the raw medicinal material.

[0016] Preferably, a method for preparing a Chinese medicine composition for treating burns comprises the following steps:

[0017] S1. Weigh rhubarb, raw sanguisorba officinalis, angelica sinensis, coptis root, phellodendron, gardenia, knotweed, inner layer of elm bark, purslane, and honeysuckle, wash, dry, chop, add water and boil, filter and remove residue to obtain decoction;

[0018] S2, concentrating the decoction obtained in step S1 under reduced pressure at 40-60° C. to 1 / 3-1 / 2 of the original volume to obtain a concentrated solution;

[0019] S3, performing nano-treatment on the concentrated solution obtained in step S2 to obtain a nano-medicine solution with a particle size of 50-200 nanometers;

[0020] S4. Add borneol to the nano-medicine solution, encapsulate the borneol and vitamin E by double-layer microcapsule encapsulation technology, and then use a high shear mixer to mix evenly, add preservatives, moisturizers and thickeners in sequence, and then add auxiliary materials and mix evenly to obtain the traditional Chinese medicine composition.

[0021] Preferably, in step S1, during the decoction process, the amount of water added is 5 to 10 times the total weight of the medicinal materials;

[0022] And / or, during the decoction process, first boil over high heat and then simmer over low heat for 2 to 3 hours;

[0023] And / or, during the filtering and removing the residue, a 200-mesh screen is used for filtering.

[0024] Preferably, citric acid is first added to the decoction obtained in step S1, and then concentrated under reduced pressure; the amount of citric acid used is 0.1-0.3% of the total weight of the decoction;

[0025] and / or, concentrating under reduced pressure at 40-60°C.

[0026] Preferably, in step S3, the specific steps of nano-processing are:

[0027] S31, placing the concentrated solution obtained in step S2 in an ultrasonic treatment device, and using ultrasonic treatment at a frequency of 20-40 kHz for 10-30 minutes to reduce the particle size of the drug solution to 50-200 nanometers;

[0028] S32, treating the drug solution after ultrasonic treatment by a high-pressure homogenizer, with a homogenization pressure of 100-200 MPa and 3-5 times of treatment to obtain a nano drug solution with uniform particle size.

[0029] Preferably, in step S4, the specific steps of the double-layer structure microcapsule encapsulation technology are:

[0030] S41, dissolving borneol and vitamin E in an appropriate amount of an organic solvent to obtain a uniform solution;

[0031] S42, mixing the obtained solution with the hydrophilic shell material solution, performing emulsification treatment, and obtaining colostrum;

[0032] S43, adding a polylactic acid-glycolic acid copolymer solution to the colostrum, and emulsifying the colostrum again to obtain a double-layer microcapsule encapsulation solution;

[0033] S44. The microcapsule coating liquid is spray-dried to obtain microcapsule powder, which is then dispersed in the nano-medicine solution and stirred evenly using a high shear mixer to ensure that the coated borneol and vitamin E are evenly distributed in the medicine solution.

[0034] Preferably, the Chinese medicine composition is used in the preparation of medicines for treating burns.

[0035] Compared with the prior art, the technical solution of the present invention has at least the following technical effects:

[0036] 1. The present invention uses a combination of multiple Chinese herbal medicines such as rhubarb, raw sanguisorba officinalis, angelica, coptis root, phellodendron, gardenia, knotweed, elm bark inner layer, purslane and honeysuckle to fully utilize the synergistic effect of each Chinese herbal medicine, and achieves significant technical effects of clearing away heat and detoxification, reducing swelling and relieving pain, and promoting wound healing. Compared with the technical solutions of a single Chinese herbal medicine or a simple mixture in the prior art, the present invention significantly improves the comprehensiveness of the drug effect and the therapeutic effect, and accelerates the healing speed of burns.

[0037] 2. The present invention adds moisturizers (such as glycerin) and thickeners (such as xanthan gum) to the medicine, which can effectively keep the skin moist, prevent dryness and tightness, and at the same time increase the viscosity of the medicine, making it easier to apply and adhere to the skin. Compared with the medicine in the prior art that lacks these additives, the present invention has significantly improved the use experience, making the medicine more stable and user-friendly.

[0038] 3. The preparation method of the present invention introduces technical means such as vacuum concentration and ultrasonic treatment. The vacuum concentration method can concentrate the liquid medicine at a lower temperature, retain the effective ingredients in the liquid medicine to the maximum extent, and avoid the loss of ingredients caused by high temperature treatment; the ultrasonic treatment technology makes the liquid medicine more uniform, effectively solving the problem of uneven distribution of ingredients in traditional processes. In addition, the present invention also adopts nano-processing and double-layer microcapsule packaging technology to further improve the permeability, stability and release control of the drug, ensuring the high efficiency and consistency of the liquid medicine.

[0039] 4. Through nano-processing and double-layer microencapsulation technology, the drug of the present invention not only improves the bioavailability, but also prolongs the stability and release time of the active ingredients, significantly improving the therapeutic depth and duration of the efficacy of the drug, and is particularly suitable for various types of burns, including superficial II degree and deep II degree burns. DETAILED DESCRIPTION

[0040] In order to make the purpose, technical scheme and advantages of the present invention clearer, the technical scheme in the embodiment of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. It should be understood by those skilled in the art that the embodiments are only to help understand the present invention and should not be regarded as specific limitations of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in the field without making creative work are within the scope of protection of the present invention. The process parameters of the following embodiments that do not specify specific conditions are usually based on conventional conditions.

[0041] The endpoints and any values ​​of the ranges disclosed in the present invention are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoint values ​​of each range, the endpoint values ​​of each range and the individual point values, and the individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be regarded as specifically disclosed in the present invention.

[0042] According to a first aspect of the present invention, there is provided a Chinese medicine composition for treating burns, comprising the following components in parts by weight: comprising the following components: 10-15 parts (e.g. 10, 11, 12, 13, 14, 15 parts) of rhubarb, 10-15 parts (e.g. 10, 11, 12, 13, 14, 15 parts) of raw sanguisorba officinalis, 10-20 parts (e.g. 10, 11, 12, 13, 14, 15 parts) of angelica sinensis, 5-10 parts (e.g. 5, 6, 7, 8, 9, 10 parts) of coptis chinensis, 5-10 parts (e.g. 5, 6, 7, 8, 9, 10 parts) of phellodendron amurense, 10-20 parts (e.g. 10, 11, 12, 13, 14, 15 parts) of gardenia jasminoides 4 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts), Japanese knotweed 5-10 parts (for example, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts), elm bark inner layer 5-10 parts (for example, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts), purslane: 5-10 parts (for example, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts), honeysuckle: 5-10 parts ( For example, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts), borneol 2-5 parts (for example, 2 parts, 3 parts, 4 parts, 5 parts), preservative 0.1-0.5 parts (for example, 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts), moisturizer 1-3 parts (for example, 1 part, 2 parts, 3 parts), thickener 0.5-2 parts (for example, 0.5 parts, 1 part, 1.5 parts, 2 parts).

[0043] The drug compatibility principles of the Chinese medicine composition are mainly reflected in the following aspects:

[0044] Application of the principle of monarch, minister, assistant and envoy:

[0045] The present invention follows the principle of compatibility of monarch, minister, assistant and envoy in traditional Chinese medicine, and scientifically matches various medicinal materials to maximize the overall efficacy of the medicine:

[0046] Sole medicine: The present invention selects rhubarb, raw sanguisorba officinalis and gardenia as sole medicine, which have the effects of clearing away heat and detoxifying, cooling blood and stopping bleeding, and are the core ingredients for treating burns. They can quickly remove heat and toxins in the body, reduce inflammatory reactions, and promote tissue repair.

[0047] Assistant drugs: Angelica, Coptis chinensis, Phellodendron chinense and Polygonum cuspidatum are assistant drugs, assisting the main drugs to exert their therapeutic effects. Angelica has the effect of nourishing blood and promoting blood circulation, helping to repair damaged tissues; Coptis chinensis and Phellodendron chinense further enhance the effect of clearing away heat and detoxifying; Polygonum cuspidatum has the effect of reducing swelling and relieving pain, alleviating the pain caused by burns.

[0048] Adjuvants: The inner layer of elm bark, purslane and honeysuckle are used as adjuvants to further enhance the overall efficacy. These herbs can not only enhance the efficacy of the main and auxiliary drugs, but also prevent the toxicity or side effects of the drugs, ensuring the safety of treatment.

[0049] Adjuvant drug: Borneol, as an adjuvant drug, has the function of guiding all drugs to the affected area, and can also promote the absorption of drugs in the affected area and improve the therapeutic effect. Preservatives, moisturizers and thickeners play a role in stabilizing the physical properties of drugs and improving the user experience.

[0050] Application of the principle of mutual dependence:

[0051] The medicinal materials in the present invention enhance the overall efficacy of the medicine by combining them in a complementary and mutually beneficial way:

[0052] Mutually dependent: For example, the combination of rhubarb and coptis chinensis, raw sanguisorba officinalis and honeysuckle can synergize with each other in clearing heat and detoxifying, making the effect of the medicine more significant.

[0053] Mutual use: For example, the combination of Angelica sinensis and Gardenia jasminoides further enhances the effect of cooling blood and detoxifying, while also having the function of nourishing blood and activating blood circulation, making the treatment more comprehensive.

[0054] Principles of overall regulation and yin-yang balance:

[0055] When making the combination, the present invention not only considers the treatment of the local burn, but also pays attention to the regulation of the whole body to achieve the effect of strengthening the body and eliminating evil:

[0056] Strengthening the body and eliminating pathogenic factors: Through the combination of multiple functions such as nourishing blood and activating blood circulation, clearing away heat and detoxifying, the medicine of the present invention can regulate the internal environment of the body and prevent the recurrence of burns while eliminating pathogenic factors.

[0057] Balance of Yin and Yang: The medicinal material combination of the present invention achieves a balance in Yin and Yang. It contains both cold medicines that clear away heat and cool blood (such as rhubarb and coptis chinensis), and warm medicines that replenish blood and promote blood circulation (such as angelica sinensis), ensuring that long-term use of the medicines will not cause new imbalances. The combination is suitable for patients with various constitutions.

[0058] Synergistic effects supported by modern pharmacology:

[0059] The present invention fully considers the research results of modern pharmacology in the selection and compatibility of medicinal materials:

[0060] Anti-inflammatory and antibacterial: Medicinal materials such as rhubarb, coptis chinensis, gardenia, honeysuckle, etc. have significant anti-inflammatory and antibacterial effects, and can effectively prevent and control infections in the burned areas.

[0061] Promote tissue regeneration: Medicinal herbs such as angelica, knotweed, and the inner layer of elm bark contain active ingredients that promote skin and soft tissue regeneration, help accelerate wound healing, and reduce scar formation.

[0062] Drug permeability: Borneol not only has an analgesic effect, but also can improve the permeability of other medicinal ingredients, allowing the drug to act faster and deeper on the burned area, improving the overall therapeutic effect.

[0063] Collaborative enhancement and security assurance:

[0064] The compatibility of medicinal materials in the present invention emphasizes synergistic enhancement and safety assurance:

[0065] Synergistic enhancement: The medicinal materials enhance each other and improve the comprehensive efficacy of the medicine. For example, the combination of raw Sanguisorba officinalis and Gardenia jasminoides can enhance the effect of cooling blood and stopping bleeding, and the combination of Phellodendron chinense and Coptis chinensis can more effectively clear away heat and detoxify.

[0066] Safety assurance: When combining drugs, the toxicity and side effects of the medicinal materials are fully considered, and reasonable dosage and ingredient selection are used to ensure the safety of patients during use and minimize side effects.

[0067] In summary, the Chinese medicine composition of the present invention fully combines the classical theories of traditional Chinese medicine and the research results of modern pharmacology through careful selection of medicinal materials and scientific compatibility, and not only has significant therapeutic effects in treating scalds, but also ensures the safety and use experience of the medicine. The composition provides a more effective and comprehensive treatment plan for scald patients and has broad application prospects.

[0068] The weight parts of the present invention mainly include the disclosed numerical range, any numerical value (including integer and decimal) or any interval of two numerical values ​​in the disclosed range, or multiple discontinuous intervals, and also include numerical values ​​or numerical ranges close to the end value of the numerical range whose effects can be expected to be similar, such as 5-10 parts, not only including 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts and any interval of two parts, for other numerical ranges, not exemplified one by one, all are included in the present invention. Therefore, the present invention also includes the sub-range of any numerical range that has been directly disclosed or any specific numerical value therein.

[0069] The conventional effects of the selected medicinal materials in the present invention are as follows:

[0070] Rhubarb: bitter in taste, cold in nature; enters the spleen, stomach, and large intestine meridians; has the effects of clearing away heat and purging fire, purging qi and attacking accumulation, cooling blood and detoxifying, and removing blood stasis and dredging menstruation.

[0071] Raw Sanguisorba officinalis: slightly cold in nature, bitter, sour and astringent in taste; enters the liver meridian and large intestine meridian; has the effects of cooling blood and stopping bleeding, detoxifying and healing sores.

[0072] Angelica: It tastes sweet, is spicy and slightly warm; it enters the liver, heart and spleen meridians; it has the effects of nourishing blood and activating blood circulation, regulating menstruation and relieving pain, and moistening the intestines and promoting bowel movements.

[0073] Coptis chinensis: cold in nature, bitter in taste; enters the heart, spleen, stomach, gallbladder, and large intestine meridians; has the effects of clearing away heat and dampness, purging fire and detoxifying;

[0074] Huangbai: cold and bitter; enters the kidney meridian, bladder meridian, and large intestine meridian; has the effects of clearing away heat and dampness, purging fire and detoxifying, and eliminating bone steaming.

[0075] Gardenia: bitter and cold in taste; enters the heart, lung and triple burner meridians; has the effects of purging fire and relieving restlessness, clearing heat and removing dampness, cooling blood and detoxifying.

[0076] Polygonum cuspidatum: slightly bitter and slightly cold; enters the liver, gallbladder, and lung meridians; has the effects of promoting dampness and relieving jaundice, clearing away heat and detoxifying, dispersing blood stasis and relieving pain, and resolving phlegm and relieving cough.

[0077] Portulaca oleracea: sour in taste, cold in nature; enters the liver, spleen, and large intestine meridians; has the effects of clearing away heat and detoxifying, cooling blood and stopping bleeding, promoting diuresis and reducing swelling, and removing dampness and relieving stranguria.

[0078] Honeysuckle: sweet in taste, cold in nature; enters the lung, heart, and stomach meridians; has the effects of clearing away heat and detoxifying, dispersing wind-heat, cooling blood and stopping diarrhea.

[0079] In order to further optimize the efficacy of the Chinese medicine composition for treating scalds, the present invention studies the influence of different proportions of various raw medicinal materials on the efficacy, and obtains the optimal proportions of the Chinese medicine composition, wherein the optimal proportion of the Chinese medicine composition is: 14 parts of rhubarb, 14 parts of raw sanguisorba officinalis, 20 parts of angelica, 7 parts of coptis chinensis, 7 parts of phellodendron amurense, 20 parts of gardenia, 7 parts of knotweed, 7 parts of inner layer of elm bark, 7 parts of purslane, 7 parts of honeysuckle, 2-5 parts of borneol, 0.1-0.5 parts of preservatives, 1-3 parts of moisturizers, and 0.5-2 parts of thickeners.

[0080] In the above-mentioned Chinese medicine composition, as a preferred embodiment, the preservative is selected from one or a combination of the following: sodium benzoate, benzoic acid, potassium sorbate, methylparaben, ethylparaben;

[0081] Optionally, the moisturizer is selected from one or a combination of the following: glycerin, propylene glycol, butylene glycol, sodium hyaluronate;

[0082] Optionally, the thickener is selected from one of the following or a combination thereof: xanthan gum, sodium carboxymethyl cellulose, guar gum, sodium alginate.

[0083] In the above-mentioned traditional Chinese medicine composition, as a preferred embodiment, it also includes auxiliary materials: the auxiliary materials include one or a combination of the following ingredients: vitamin E, aloe extract, tea polyphenols, allantoin;

[0084] Optionally, the amount of the excipient is 0.1-1% (e.g., 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%) of the total weight of the raw medicinal material.

[0085] According to a second aspect of the present invention, there is also provided a method for preparing the above-mentioned Chinese medicine composition, which comprises the following steps:

[0086] S1. Weigh rhubarb, raw sanguisorba officinalis, angelica sinensis, coptis root, phellodendron, gardenia, knotweed, inner layer of elm bark, purslane, and honeysuckle, wash, dry, chop, add water and boil, filter and remove residue to obtain decoction;

[0087] S2, concentrating the decoction obtained in step S1 under reduced pressure at 40-60° C. to 1 / 3-1 / 2 of the original volume to obtain a concentrated solution;

[0088] S3, performing nano-treatment on the concentrated solution obtained in step S2 to obtain a nano-medicine solution with a particle size of 50-200 nanometers;

[0089] S4. Add borneol to the nano-medicine solution, encapsulate the borneol and vitamin E by double-layer microcapsule encapsulation technology, and then use a high shear mixer to mix evenly, add preservatives, moisturizers and thickeners in sequence, and then add auxiliary materials and mix evenly to obtain the traditional Chinese medicine composition.

[0090] In the above preparation method, as a preferred embodiment, in step S1, during the decoction process, the amount of water added is 5 to 10 times (such as 5 times, 6 times, 7 times, 8 times, 9 times, 10 times) the total weight of the medicinal materials;

[0091] Optionally, during the decoction process, first boil over high heat and then simmer over low heat for 2 to 3 hours;

[0092] Optionally, during the filtering and removing of residues, a 200-mesh screen is used for filtering.

[0093] In the above preparation method, as a preferred embodiment, in step S3, the specific steps of nano-processing are:

[0094] S31, placing the concentrated solution obtained in step S2 in an ultrasonic treatment device, and using ultrasonic treatment at a frequency of 20-40 kHz for 10-30 minutes to reduce the particle size of the drug solution to 50-200 nanometers;

[0095] S32, treating the drug solution after ultrasonic treatment by a high-pressure homogenizer, with a homogenization pressure of 100-200 MPa and 3-5 times of treatment to obtain a nano drug solution with uniform particle size.

[0096] In the above preparation method, as a preferred embodiment, in step S4, the specific steps of the double-layer structure microcapsule encapsulation technology are:

[0097] S41, dissolving borneol and vitamin E in an appropriate amount of an organic solvent to obtain a uniform solution;

[0098] S42, mixing the obtained solution with the hydrophilic shell material solution, performing emulsification treatment, and obtaining colostrum;

[0099] S43, adding a polylactic acid-glycolic acid copolymer solution to the colostrum, and emulsifying the colostrum again to obtain a double-layer microcapsule encapsulation solution;

[0100] S44. The microcapsule coating liquid is spray-dried to obtain microcapsule powder, which is then dispersed in the nano-medicine solution and stirred evenly using a high shear mixer to ensure that the coated borneol and vitamin E are evenly distributed in the medicine solution.

[0101] According to a third aspect of the present invention, provided is the use of the above-mentioned Chinese medicine composition and the Chinese medicine composition prepared by the above-mentioned preparation method in preparing medicine for treating burns.

[0102] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in combination with the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0103] Example 1

[0104] This embodiment provides a Chinese medicine composition for treating burns, and the weight proportions of the raw medicinal materials are as follows:

[0105] Rhubarb: 12 parts, raw sanguisorba officinalis: 12 parts, angelica: 18 parts, coptis: 8 parts, phellodendron: 8 parts, gardenia: 15 parts, knotweed: 8 parts, elm bark inner layer: 8 parts, purslane: 7 parts, honeysuckle: 7 parts, borneol: 3 parts, preservative (sodium benzoate): 0.3 parts, humectant (glycerin): 2.5 parts, thickener (xanthan gum): 1.2 parts.

[0106] The preparation method of the Chinese medicine composition for treating burns in this embodiment is as follows:

[0107] Medicinal material processing: Weigh rhubarb, raw sanguisorba officinalis, angelica, coptis root, phellodendron, gardenia, knotweed, inner layer of elm bark, purslane, honeysuckle, wash, dry and chop.

[0108] Decoction extraction: Put the processed medicinal materials into a pot, add water (7 times the total weight of the medicinal materials), boil over high heat and then simmer over low heat for 2.5 hours, filter out the residue, and obtain the decoction.

[0109] Concentration under reduced pressure: Concentrate the decoction under reduced pressure at 50°C to 1 / 3 of the original volume to obtain a concentrated solution.

[0110] Nano-treatment: The concentrated solution was placed in an ultrasonic treatment device and treated with ultrasound at a frequency of 30 kHz for 20 minutes, followed by treatment with a 150 MPa high-pressure homogenizer for 3 times to obtain a nano-drug solution with a particle size of 100 nanometers.

[0111] Microcapsule encapsulation: Add borneol to the nano-medicine solution, dissolve borneol and vitamin E in an appropriate amount of organic solvent, mix with hydrophilic shell material, emulsify to obtain colostrum, add polylactic acid-glycolic acid copolymer solution, perform a second emulsification treatment, spray dry to obtain microcapsule powder, disperse the microcapsule powder in the nano-medicine solution, and stir evenly using a high shear mixer.

[0112] Additives: add preservatives, moisturizers and thickeners in sequence, stir evenly, and obtain the final Chinese medicine composition.

[0113] Summary of Example 1: The drug prepared by the above process has high efficacy and excellent use experience, can significantly accelerate the healing of burns, and keep the skin moist during use.

[0114] Example 2

[0115] This embodiment provides a Chinese medicine composition for treating burns, and the weight proportions of the raw medicinal materials are as follows:

[0116] Rhubarb: 10 parts, raw sanguisorba officinalis: 10 parts, angelica: 20 parts, coptis: 7 parts, phellodendron: 7 parts, gardenia: 20 parts, knotweed: 7 parts, elm bark inner layer: 7 parts, purslane: 7 parts, honeysuckle: 7 parts, borneol: 4 parts, preservative (potassium sorbate): 0.2 parts, humectant (propylene glycol): 3 parts, thickener (sodium carboxymethyl cellulose): 1.5 parts.

[0117] The preparation method of the Chinese medicine composition for treating burns in this embodiment is as follows:

[0118] Medicinal material processing: the same as in Example 1.

[0119] Decoction extraction: Put the processed medicinal materials into a pot, add water (8 times the total weight of the medicinal materials), boil over high heat and then simmer over low heat for 2 hours, filter out the residue, and obtain the decoction.

[0120] Concentrate under reduced pressure: Concentrate under reduced pressure at 60°C to 1 / 2 of the original volume to obtain a concentrated solution.

[0121] Nano-treatment: Ultrasonic treatment with a frequency of 25 kHz was used for 15 minutes, followed by treatment with a 120 MPa high-pressure homogenizer for 5 times to obtain a nano-drug solution with a particle size of 150 nanometers.

[0122] Microencapsulation: Same as Example 1.

[0123] Additives: Same as in Example 1.

[0124] Summary of Example 2: The formula and process parameters of Example 2 were adjusted, and the drug had good moisture retention and stability, and was suitable for the treatment of milder burns.

[0125] Example 3

[0126] This embodiment provides a Chinese medicine composition for treating burns, and the weight proportions of the raw medicinal materials are as follows:

[0127] Rhubarb: 14 parts, raw sanguisorba officinalis: 14 parts, angelica: 20 parts, coptis: 7 parts, phellodendron: 7 parts, gardenia: 20 parts, knotweed: 7 parts, elm bark inner layer: 7 parts, purslane: 7 parts, honeysuckle: 7 parts, borneol: 5 parts, preservative (benzoic acid): 0.4 parts, humectant (butylene glycol): 2.5 parts, thickener (guar gum): 1 part.

[0128] The preparation method of the Chinese medicine composition for treating burns in this embodiment is as follows:

[0129] Medicinal material processing: Same as Example 1.

[0130] Decoction extraction: Put the processed medicinal materials into a pot, add water (9 times the total weight of the medicinal materials), boil over high heat and then simmer over low heat for 3 hours, filter out the residue, and obtain the decoction.

[0131] Concentrate under reduced pressure: Concentrate under reduced pressure at 45°C to 1 / 2 of the original volume to obtain a concentrated solution.

[0132] Nano-treatment: Ultrasonic treatment with a frequency of 35 kHz was used for 25 minutes, followed by treatment with a high-pressure homogenizer at 180 MPa for 4 times to obtain a nano-drug solution with a particle size of 75 nanometers.

[0133] Microencapsulation: Same as Example 1.

[0134] Additives: Same as in Example 1.

[0135] Summary of Example 3: Example 3 uses a higher concentration of active ingredients and more sophisticated nano-processing, and the permeability and sustainability of the drug's efficacy are significantly enhanced, making it suitable for more severe burns.

[0136] Example 4

[0137] This embodiment provides a Chinese medicine composition for treating burns, and the weight proportions of the raw medicinal materials are as follows:

[0138] Rhubarb: 13 parts, raw sanguisorba officinalis: 13 parts, angelica: 18 parts, coptis: 6 parts, phellodendron: 6 parts, gardenia: 18 parts, knotweed: 6 parts, elm bark inner layer: 6 parts, purslane: 6 parts, honeysuckle: 6 parts, borneol: 3.5 parts, preservative (methylparaben): 0.3 parts, moisturizer (sodium hyaluronate): 2.2 parts, thickener (sodium alginate): 1.3 parts.

[0139] The preparation method of the Chinese medicine composition for treating burns in this embodiment is as follows:

[0140] Medicinal material processing: Same as Example 1.

[0141] Decoction extraction: Put the processed medicinal materials into a pot, add water (8.5 times the total weight of the medicinal materials), boil over high heat and then simmer over low heat for 2.5 hours, filter out the residue, and obtain the decoction.

[0142] Concentrate under reduced pressure: Concentrate under reduced pressure at 55°C to 1 / 3 of the original volume to obtain a concentrated solution.

[0143] Nano-treatment: Ultrasonic treatment with a frequency of 30 kHz was used for 20 minutes, followed by treatment with a 140 MPa high-pressure homogenizer for 4 times to obtain a nano-drug solution with a particle size of 120 nanometers.

[0144] Microencapsulation: Same as Example 1.

[0145] Additives: Same as in Example 1.

[0146] Summary of Example 4: Example 4 makes adjustments in the selection of humectants and thickeners. The moisturizing effect of the drug is better and is suitable for daily care and treatment of small-area burns.

[0147] Example 5

[0148] This embodiment provides a Chinese medicine composition for treating burns, and the weight proportions of the raw medicinal materials are as follows:

[0149] Rhubarb: 15 parts, raw sanguisorba officinalis: 15 parts, angelica: 15 parts, coptis root: 5 parts, phellodendron: 5 parts, gardenia: 15 parts, knotweed: 5 parts, elm bark inner layer: 5 parts, purslane: 5 parts, honeysuckle: 5 parts, borneol: 4 parts, preservative (sodium benzoate): 0.3 parts, humectant (glycerin): 3 parts, thickener (xanthan gum): 1.5 parts.

[0150] The preparation method of the Chinese medicine composition for treating burns in this embodiment is as follows:

[0151] Medicinal material processing: the same as in Example 1.

[0152] Decoction extraction: Put the processed medicinal materials into a pot, add water (9 times the total weight of the medicinal materials), boil over high heat and then simmer over low heat for 3 hours, filter out the residue, and obtain the decoction.

[0153] Concentrate under reduced pressure: Concentrate under reduced pressure at 50°C to 1 / 2 of the original volume to obtain a concentrated solution.

[0154] Nano-treatment: Ultrasonic treatment with a frequency of 35 kHz was used for 30 minutes, followed by treatment with a 160 MPa high-pressure homogenizer for 4 times to obtain a nano-drug solution with a particle size of 80 nanometers.

[0155] Microencapsulation: Same as Example 1.

[0156] Additives: Same as in Example 1.

[0157] Summary of Example 5: Example 5 has a higher active ingredient concentration and an optimized preparation process, and the drug has excellent performance in treating the depth and duration of burns, and is suitable for treating larger areas and deeper burns.

[0158] Comparative experiment

[0159] In order to verify the superiority of the Chinese medicine composition for treating scalds of the present invention, the following comparative experiment was designed. The comparative experiment compared the embodiments of the present invention with the scald medicine products on the existing market in detail, and analyzed the differences in their efficacy, use experience and preparation process.

[0160] Comparative experiment 1: drug efficacy comparison

[0161] Experimental design:

[0162] Experimental Group:

[0163] Example 1: The formula and process are as described above, using a combination of medicinal materials such as rhubarb, raw sanguisorba officinalis, angelica, coptis root, phellodendron, gardenia, knotweed, inner layer of elm bark, purslane, and honeysuckle, and prepared by reduced pressure concentration, nano-processing and double-layer structure microencapsulation technology.

[0164] Example 3: High concentration of active ingredients and fine nano-processing are used, the efficacy is strong and it is suitable for more serious burns.

[0165] Example 5: Using a higher concentration of active ingredients, suitable for larger areas and deeper burns

[0166] The market product used in control group A is "Compound Rhubarb Paste", the main ingredient of which is rhubarb extract, supplemented with a small amount of preservatives and thickeners. The formula and preparation process of the product are as follows:

[0167] formula:

[0168] Rhubarb extract: 100 parts

[0169] Sodium benzoate: 0.2 parts

[0170] Xanthan gum: 1 part

[0171] The rest is water

[0172] Preparation process:

[0173] Wash, dry and crush the rhubarb, add 10 times the weight of water, boil at normal pressure for 3 hours, filter and remove the residue to obtain the rhubarb extract.

[0174] The extract was continued to be boiled under normal pressure and concentrated to 1 / 3 of the original volume.

[0175] Sodium benzoate and xanthan gum are added and stirred to obtain an ointment.

[0176] Experimental methods:

[0177] Experimental subjects: A total of 50 subjects were randomly divided into 4 groups, with 12-13 people in each group.

[0178] How to use: Apply to the affected area three times a day for 10 consecutive days.

[0179] Evaluation indicators:

[0180] Healing time: The time it takes for a wound to heal from the first use.

[0181] Antibacterial effect: evaluated by the infection status of the wound and the results of bacterial culture.

[0182] Pain relief effect: The pain change after using the drug was evaluated by the subjects' pain rating scale (0-10 points).

[0183] Experimental data:

[0184] Group Healing time Antibacterial effect Pain relief effect Example 1 7 days excellent 8-10 points Example 3 6 days excellent 8-10 points Example 5 5 days excellent 9-10 points Control group A 12 days generally 5-7 points

[0185] analyze:

[0186] The efficacy of Examples 1, 3, and 5 was significantly better than that of Control Group A, and the healing time was shortened by 5-7 days, which shows the high efficiency of the drug of the present invention.

[0187] The antibacterial effect of the embodiment group showed significant advantages, especially the ability to prevent infection was stronger.

[0188] In terms of pain relief effect, the pain score of the Example group was significantly higher than that of the Control Group A, indicating that the composition of the present invention is more effective in relieving pain caused by burns.

[0189] Comparative experiment 2: User experience comparison

[0190] Experimental design:

[0191] Experimental Group:

[0192] Example 2: The formula and process are as described above, using propylene glycol with good moisturizing effect and sodium carboxymethyl cellulose with significant thickening effect.

[0193] Example 4: The formula and process are as described above, using sodium hyaluronate with strong moisturizing properties and sodium alginate with stable thickening effect.

[0194] Control group B: Use the common potion "iodine solution" on the market without adding moisturizer and thickener. This product is mainly used for surface disinfection and auxiliary treatment of mild burns. Its formula and process are as follows:

[0195] formula:

[0196] Iodine: 10%

[0197] Water: 90%

[0198] Preparation process:

[0199] Dissolve iodine tincture in deionized water, stir briefly to mix, and then bottle.

[0200] Experimental methods:

[0201] Experimental subjects: 30 subjects were divided into 3 groups, with 10 people in each group.

[0202] How to use: Apply to the burned area three times a day for 10 consecutive days.

[0203] Evaluation indicators:

[0204] Ease of application: Subjects rated how easy it was to apply the medication.

[0205] Moisturizing effect: Evaluate the dryness and skin tightness of the burned area after applying the medicine.

[0206] User satisfaction: This is a comprehensive assessment of drug efficacy, application experience, skin comfort and other factors, and is scored by the subjects (0-100 points).

[0207] Experimental data:

[0208] Group Ease of application Moisturizing effect Customer satisfaction Example 2 excellent excellent 0.95 Example 4 good excellent 0.92 Control group B generally generally 0.7

[0209] analyze:

[0210] The ease of application and moisturizing effect of Examples 2 and 4 are significantly better than those of Control Group B, especially in terms of moisturizing effect. The introduction of sodium hyaluronate and sodium carboxymethyl cellulose greatly improves the skin's ability to retain moisture.

[0211] The user satisfaction score shows that the compositions of Examples 2 and 4 are much better than the control group B in terms of usage experience, especially in terms of the comprehensive performance of skin comfort and efficacy.

[0212] Comparative experiment 3: Preparation process comparison

[0213] Experimental design:

[0214] Experimental Group:

[0215] Example 1: Using nano-processing and double-layer structure microencapsulation technology.

[0216] Example 2: Using nano-processing and double-layer structure microencapsulation technology.

[0217] Example 4: Using nano-processing and double-layer structure microencapsulation technology.

[0218] Control group C: The same formula of medicine, such as "safflower oil", was prepared by traditional normal pressure boiling concentration and simple stirring method. The preparation process is as follows:

[0219] formula:

[0220] Safflower oil: 100 parts

[0221] Other Chinese herbal extracts: appropriate amount

[0222] Water: Balance

[0223] Preparation process:

[0224] All medicinal materials were extracted by conventional methods, concentrated to 1 / 3 volume by boiling at normal pressure, stirred evenly and then directly bottled.

[0225] Experimental methods:

[0226] Experimental subjects: Comparison of drugs with the same formulation but different preparation processes.

[0227] Evaluation indicators:

[0228] Preparation time: the time from the start to the completion of drug preparation.

[0229] Ingredient retention rate: the difference in the content of the main active ingredients in the drug solution before and after preparation.

[0230] Uniformity of drug solution: the uniformity of the distribution of the main components in the drug solution.

[0231] Experimental data:

[0232] Group Preparation time Ingredient retention rate Liquid uniformity Example 1 4 hours 0.95 excellent Example 2 3.5 hours 0.93 good Example 4 4 hours 0.94 good Control group C 3 hours 0.85 generally

[0233] analyze:

[0234] Although the preparation time of control group C was slightly shorter, the lack of nano-processing and microencapsulation technology resulted in low ingredient retention rate and poor uniformity of the drug solution.

[0235] The advanced technology adopted in the embodiment group, especially the nano-sizing and microencapsulation technology, greatly improves the retention rate and uniformity of the active ingredients in the drug solution, thereby improving the overall efficacy of the drug.

[0236] Summarize

[0237] Through the above comparative experiments, the significant advantages of the Chinese medicine composition of the present invention in terms of efficacy, user experience and preparation process are fully verified. The present invention not only solves the deficiencies in the prior art in terms of the combination of drug ingredients and process improvement, but also demonstrates its superior performance in practical applications through a number of experimental data. The above results show that the Chinese medicine composition of the present invention has higher efficacy, better user experience and more stable preparation process, providing a more effective and convenient option for treating burns.

[0238] The above describes and evaluates the efficacy of some embodiments of the present invention. It should be understood that the present invention is not limited to the above specific implementations. Any technician familiar with the art can use the above disclosed methods and technical contents to make many possible changes and modifications to the technical solutions of the present invention without departing from the scope of the technical solutions of the present invention, or modify them into equivalent embodiments of equivalent changes, which does not affect the essential content of the present invention. Therefore, any simple modification, equivalent change and modification made to the above embodiments according to the technical essence of the present invention without departing from the content of the technical solutions of the present invention still falls within the scope of protection of the technical solutions of the present invention.

Claims

1. A Chinese medicine composition for treating burns, characterized in that: The invention comprises the following components by weight: 10-15 parts of rhubarb, 10-15 parts of raw sanguisorba officinalis, 10-20 parts of angelica sinensis, 5-10 parts of coptis chinensis, 5-10 parts of phellodendron amurense, 10-20 parts of gardenia jasmine, 5-10 parts of knotweed, 5-10 parts of inner layer of elm bark, 5-10 parts of purslane, 5-10 parts of honeysuckle, 2-5 parts of borneol, 0.1-0.5 parts of preservative, 1-3 parts of humectant and 0.5-2 parts of thickener.

2. The Chinese medicine composition according to claim 1, characterized in that: The invention comprises the following components by weight: 14 parts of rhubarb, 14 parts of raw sanguisorba officinalis, 20 parts of angelica sinensis, 7 parts of coptis chinensis, 7 parts of phellodendron amurense, 20 parts of gardenia jasminoides, 7 parts of knotweed, 7 parts of inner layer of elm bark, 7 parts of purslane, 7 parts of honeysuckle, 5 parts of borneol, 0.4 parts of preservative, 3 parts of moisturizer and 1 part of thickener.

3. The Chinese medicine composition according to claim 1, characterized in that The preservative is selected from one or a combination of the following: sodium benzoate, benzoic acid, potassium sorbate, methylparaben, ethylparaben; And / or, the moisturizing agent is selected from one or a combination of the following: glycerin, propylene glycol, butylene glycol, sodium hyaluronate; And / or, the thickener is selected from one of the following or a combination thereof: xanthan gum, sodium carboxymethyl cellulose, guar gum, sodium alginate.

4. The Chinese medicine composition according to any one of claims 1 to 3, characterized in that: Also includes auxiliary materials: the auxiliary materials include one or a combination of the following ingredients: vitamin E, aloe extract, tea polyphenols, allantoin; And / or, the amount of the auxiliary material is 0.1-1% of the total weight of the raw medicinal material.

5. A method for preparing the Chinese medicine composition according to any one of claims 1 to 4, characterized in that: The following steps are involved: S1. Weigh rhubarb, raw sanguisorba officinalis, angelica sinensis, coptis root, phellodendron, gardenia, knotweed, inner layer of elm bark, purslane, and honeysuckle, wash, dry, chop, add water and boil, filter and remove residue to obtain decoction; S2, concentrating the decoction obtained in step S1 under reduced pressure at 40-60° C. to 1 / 3-1 / 2 of the original volume to obtain a concentrated solution; S3, performing nano-treatment on the concentrated solution obtained in step S2 to obtain a nano-medicine solution with a particle size of 50-200 nanometers; S4. Add borneol to the nano-medicine solution, encapsulate the borneol and vitamin E by double-layer microcapsule encapsulation technology, and then use a high shear mixer to mix evenly, add preservatives, moisturizers and thickeners in sequence, and then add auxiliary materials and mix evenly to obtain the traditional Chinese medicine composition.

6. The preparation method according to claim 5, characterized in that: In step S1, during the decoction process, the amount of water added is 5 to 10 times the total weight of the medicinal materials; And / or, during the decoction process, first boil over high heat and then simmer over low heat for 2 to 3 hours; And / or, during the filtering and removing the residue, a 200-mesh screen is used for filtering.

7. The preparation method according to claim 5, characterized in that: Firstly add citric acid to the decoction obtained in step S1, and then concentrate under reduced pressure; the amount of citric acid used is 0.1-0.3% of the total weight of the decoction; and / or, concentrating under reduced pressure at 40-60°C.

8. The preparation method according to claim 5, characterized in that: In step S3, the specific steps of nano-processing are: S31, placing the concentrated solution obtained in step S2 in an ultrasonic treatment device, and using ultrasonic treatment at a frequency of 20-40 kHz for 10-30 minutes to reduce the particle size of the drug solution to 50-200 nanometers; S32, treating the drug solution after ultrasonic treatment by a high-pressure homogenizer, with a homogenization pressure of 100-200 MPa and 3-5 times of treatment to obtain a nano drug solution with uniform particle size.

9. The preparation method according to claim 5, characterized in that: In step S4, the specific steps of the double-layer structure microcapsule encapsulation technology are: S41, dissolving borneol and vitamin E in an appropriate amount of an organic solvent to obtain a uniform solution; S42, mixing the obtained solution with the hydrophilic shell material solution, performing emulsification treatment, and obtaining colostrum; S43, adding a polylactic acid-glycolic acid copolymer solution to the colostrum, and emulsifying the colostrum again to obtain a double-layer microcapsule encapsulation solution; S44. The microcapsule coating liquid is spray-dried to obtain microcapsule powder, which is then dispersed in the nano-medicine solution and stirred evenly using a high shear mixer to ensure that the coated borneol and vitamin E are evenly distributed in the medicine solution.

10. Use of the Chinese medicine composition according to any one of claims 1 to 4 and the Chinese medicine composition prepared by the preparation method according to any one of claims 5 to 9 in preparing medicine for treating burns.