Atomization control method and system based on breathing machine

Abstract

The invention provides an atomization control method and system based on a breathing machine, and belongs to the technical field of breathing gas instruments. The method comprises the steps that after receiving a handshake request signal from a second microcontroller, a first microcontroller establishes serial port communication connection with an atomizer based on the handshake request signal so as to receive an atomizer control protocol sent by the second microcontroller; wherein the handshake request signal is generated based on the operation that the communication wire is connected to the communication interface of the atomizer; the atomizer control protocol at least comprises an instruction required by the respirator to control the atomizer; determining a breathing stage corresponding to the patient according to the breathing information of the patient from the breathing sensor; and after an atomization control instruction is received and before a breathing phase enters, according to an atomizer control protocol, continuously generating an inspiration phase fog supply instruction and sending the inspiration phase fog supply instruction to the second microcontroller, so that the atomizer carries out synchronous fog supply along with the air supply airflow of the breathing machine based on a preset delayed fog outlet duration and stops fog supply in an expiration phase.

Description

Technical Field

[0001] The present application relates to the technical field of respiratory gas equipment, and in particular to a nebulization control method and system based on a ventilator. Background Art

[0002] As a precision medical device, the core function of the nebulizer is to efficiently convert drug solutions into extremely small particles (i.e., droplets). These fine drug droplets can easily penetrate the patient's respiratory tract and reach deep into the lungs, thereby implementing precise and efficient local drug treatment. As an indispensable medical device in clinical treatment, the importance of the ventilator lies in providing necessary life support for patients suffering from respiratory failure, respiratory dysfunction, etc., and effectively improving and maintaining their respiratory function.

[0003] However, in actual applications, relying solely on a nebulizer or a ventilator often fails to fully meet the complex treatment needs of patients, which places more stringent requirements on the independent operation capabilities of the equipment and their mutual collaboration. In view of this situation, it is particularly urgent to realize a technical solution that allows the nebulizer and ventilator to operate independently and efficiently, and to seamlessly connect and work together. Summary of the invention

[0004] The embodiments of the present application provide a nebulizer-based atomization control method and system, which are used to solve the technical problems that the current nebulizers and ventilators working separately cannot be simply and flexibly combined according to treatment needs to form an efficient and coordinated treatment system, and affect the patient's experience of using the equipment.

[0005] On the one hand, an embodiment of the present application provides a nebulization control method based on a ventilator, the method comprising:

[0006] After receiving the handshake request signal from the second microcontroller, the first microcontroller establishes a serial communication connection with the nebulizer based on the handshake request signal, so as to receive the nebulizer control protocol sent by the second microcontroller; wherein the handshake request signal is generated based on the operation of connecting the communication wire to the communication interface of the nebulizer; the nebulizer control protocol at least includes the instructions required for the ventilator to control the nebulizer;

[0007] Determine the corresponding respiratory stage of the patient according to the patient's respiratory information from the respiratory sensor;

[0008] After receiving the nebulization control instruction, before the breathing stage enters the inhalation phase, the inhalation phase nebulization instruction is continuously generated and sent to the second microcontroller according to the nebulizer control protocol, so that the nebulizer can synchronize the nebulization with the air supply flow of the ventilator based on the preset delayed nebulization time and stop nebulization in the expiratory phase.

[0009] In one implementation of the present application, after the first microcontroller receives the handshake request signal from the second microcontroller, the first microcontroller establishes a serial communication connection with the atomizer based on the handshake request signal, specifically including:

[0010] After the communication wire physically connects the nebulizer to the ventilator, the second microcontroller generates the handshake request signal and sends it to the nebulizer communication module through the asynchronous data transmission line, so that the nebulizer communication module sends the handshake request signal to the ventilator communication module of the ventilator through the transmission line of the serial communication interface;

[0011] The first microcontroller receives the handshake request signal from the ventilator communication module and generates a handshake response signal, and sends the handshake response signal to the second microcontroller based on the ventilator communication module and the nebulizer communication module, so that the serial port communication connection is established after the first microcontroller and the second microcontroller successfully handshake.

[0012] In one implementation of the present application, after establishing a serial communication connection with the atomizer based on the handshake request signal, the method further includes:

[0013] The second microcontroller disables the body control button of the atomizer by one of the following methods:

[0014] Disconnecting the electrical connection between the key circuit corresponding to the body control key and the second microcontroller;

[0015] disabling the command execution function of the body control button;

[0016] The method further comprises:

[0017] When the serial communication connection is disconnected, the second microcontroller generates a key control recovery signal and sends it to the key circuit of the atomizer to restore the control authority of the body control key.

[0018] In one implementation of the present application, the method further includes:

[0019] The first microcontroller obtains the operating status information of the nebulizer in real time through the serial port communication connection, and displays the operating status information on the display screen of the ventilator; the operating status information at least includes the atomization water level status obtained by the water level detection module of the nebulizer and / or the battery power of the nebulizer.

[0020] In one implementation of the present application, the nebulizer performs synchronous mist delivery with the air supply flow of the ventilator based on a preset delayed mist delivery time, specifically including:

[0021] The second microcontroller determines the reception time of the inhalation phase mist instruction, and uses the reception time as the delay start time for timing;

[0022] When the timing time reaches the preset delayed mist discharge time, a high-level pulse width modulation (PWM) signal is generated to drive the mesh sheet of the nebulizer to vibrate at the optimal operating frequency point, so that when the air supply flow of the ventilator reaches the three-way interface position set at the atomizing cup head of the nebulizer, atomizing gas accompanying the air supply flow is generated to perform synchronous mist supply.

[0023] In one implementation of the present application, the method further includes:

[0024] The second microcontroller controls the frequency sweep from an initial frequency of 90KHz, increasing by 1KHz each time, and determines the mesh sheet working efficiency characterization value corresponding to each frequency until the sweep frequency reaches a preset frequency value, so as to generate a signal frequency selection curve according to each mesh sheet working efficiency characterization value;

[0025] The sweep frequency corresponding to the minimum mesh sheet working efficiency characterization value in the signal frequency selection curve is used as the optimal working frequency point, so as to generate the corresponding PWM signal according to the optimal working frequency point to control the mesh sheet to vibrate at the optimal working frequency point.

[0026] In one implementation of the present application, the preset delayed misting time is at least positively correlated with the length of the breathing tube of the ventilator.

[0027] On the other hand, the embodiment of the present application further provides a nebulization control system based on a ventilator, the system comprising a ventilator and a nebulizer; the ventilator is provided with a display screen, a communication wire, a breathing tube, a first microcontroller, a three-way interface arranged at the end of the breathing tube, and a breathing mask;

[0028] The display screen includes a ventilator user interface, which includes a breathing control area and a breathing parameter display area, wherein the breathing control area includes at least atomization control controls, and the breathing parameter display area includes at least patient breathing parameters; the patient breathing parameters include at least: peak inspiratory pressure, tidal volume, leakage, minute ventilation, positive end-expiratory pressure PEEP, total respiratory rate, peak inspiratory flow, and oxygen concentration;

[0029] The communication wire is used to connect to the communication interface of the atomizer to establish a serial communication connection with the atomizer; the three-way interface is used to communicate with the atomizer cup head of the atomizer;

[0030] The system performs the patient's breathing atomization control through the above-mentioned ventilator-based atomization control method.

[0031] In one implementation of the present application, the atomizer further includes a water level detection module;

[0032] The water level detection module is respectively connected to the atomizer cup head and the second microcontroller, and is used to generate a water-free status signal and send it to the second microcontroller when the water level of the atomizer cup head is lower than a preset water level, so that the second microcontroller sends the water-free status signal to the first microcontroller through the communication wire, so as to update the atomization water level status in the display screen to a water-free status, and enable the first microcontroller to control the atomizer to stop responding to the inhalation phase mist supply instruction.

[0033] In one implementation of the present application, the atomizer further includes a battery power supply module and an adapter power supply module, and the power supply priority of the adapter power supply module is greater than the power supply priority of the battery power supply module;

[0034] The ventilator also includes an output power supply line for connecting to the adapter power module to power the nebulizer.

[0035] Compared with the prior art, the present invention has the following significant effects:

[0036] Through the above technical solution, a treatment system that combines a ventilator and a nebulizer and performs atomization control is realized. After the nebulizer and the ventilator are physically connected, the user can control the nebulizer through the ventilator, and can flexibly nebulize the mist according to the patient's real-time breathing information and the respiratory airflow, thereby ensuring the patient's atomization treatment effect and the utilization rate of the atomized medicine solution, while improving the user's experience of using the existing ventilator and nebulizer. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] The drawings described herein are used to provide a further understanding of the present application and constitute a part of the present application. The illustrative embodiments of the present application and their descriptions are used to explain the present application and do not constitute an improper limitation on the present application. In the drawings:

[0038] Figure 1 A schematic flow chart of a nebulization control method based on a ventilator in an embodiment of the present application;

[0039] Figure 2 This is a structural schematic diagram of a nebulizer control system based on a ventilator in an embodiment of the present application;

[0040] Figure 3 A schematic diagram of the composition and functions of a nebulizer in a nebulization control method based on a ventilator in an embodiment of the present application;

[0041] Figure 4A circuit schematic diagram of a key circuit in a nebulization control method based on a ventilator in an embodiment of the present application;

[0042] Figure 5 This is a circuit schematic diagram of a water level detection module in a nebulization control method based on a ventilator in an embodiment of the present application;

[0043] Figure 6 A circuit schematic diagram of a nebulizer power supply circuit in a nebulizer-based nebulization control method in an embodiment of the present application;

[0044] Figure 7 This is a circuit schematic diagram of a nebulizer frequency sweeping module in a nebulization control method based on a ventilator in an embodiment of the present application;

[0045] Figure 8 This is a schematic diagram of a signal frequency selection curve in a nebulization control method based on a ventilator in an embodiment of the present application. DETAILED DESCRIPTION

[0046] In order to make the purpose, technical solution and advantages of the present application clearer, the technical solution of the present application will be clearly and completely described below in combination with the specific embodiments of the present application and the corresponding drawings. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present application.

[0047] In order to achieve the goal of enabling the nebulizer and the ventilator to operate independently and efficiently while also seamlessly connecting and working together, the embodiments of the present application provide a nebulizer-based ventilator atomization control method and system to solve the technical problems that the nebulizer and ventilator that currently work separately cannot be flexibly combined according to treatment needs to form an efficient and coordinated treatment system, and that affect the patient's experience of using the equipment.

[0048] The following describes in detail various embodiments of the present application in conjunction with the accompanying drawings.

[0049] The present application embodiment provides a nebulization control method based on a ventilator, such as Figure 1 As shown, the method may include steps S101-S103:

[0050] S101, after receiving the handshake request signal from the second microcontroller, the first microcontroller establishes a serial port communication connection with the atomizer based on the handshake request signal, so as to receive the atomizer control protocol sent by the second microcontroller.

[0051] The handshake request signal is generated based on the operation of connecting the communication wire to the communication interface of the nebulizer. It is understandable that the handshake request signal is generated by the second microcontroller of the nebulizer at the moment when the communication wire establishes a physical connection relationship between the ventilator and the nebulizer when the ventilator is turned on and powered on. The nebulizer control protocol includes at least the required instructions for the ventilator to control the nebulizer.

[0052] Figure 2 The present invention is a structural schematic diagram of a nebulizer control system based on a ventilator applied to a nebulizer control method based on a ventilator, wherein the system includes a display screen 201, a communication wire 202, a breathing tube 203, a first microcontroller, a three-way interface 204 arranged at the end of the breathing tube, a breathing mask 205, a nebulizer main unit 206, a nebulizer connecting line 207, and a nebulizer cup head 208.

[0053] The first microcontroller is set in the ventilator, which can be a microcontroller unit (MCU) of the ventilator, such as the model MIMXRT1052CVL5B. The second microcontroller can be the MCU of the nebulizer, such as the model SN8F5708F / J. Among them, the nebulizer used in this application can be a split mesh nebulizer or other types of mesh nebulizers, which are not specifically limited in this application. The composition and function diagram of the nebulizer is shown in FIG. Figure 3 As shown, including:

[0054] Power management circuit module: adjusts the input battery voltage to the required working voltage and provides it to each unit of the system. Battery module: provides power for the entire system. And detects the remaining battery power in real time. Key circuit module: identifies whether the user has turned the machine on or off. LED module: displays the working status of the atomizer through LED lights, and prompts that the battery needs to be replaced. Drive circuit module: amplifies the high-frequency signal generated by the single-chip microcomputer, drives the atomization mesh sheet to vibrate, and produces medicine mist. Single-chip microcomputer module (i.e., the first microcontroller): a processor with a high-speed operating frequency, generates a high-frequency signal through PWM output, and converts the external voltage signal into a digital signal through an AD acquisition circuit, and the frequency sweeping intelligent recognition algorithm is solidified in it. Liquid shortage protection circuit: used to realize the waterless shutdown of the atomizer when there is no water.

[0055] In the embodiment of the present application, after the first microcontroller receives the handshake request signal from the second microcontroller, the first microcontroller establishes a serial communication connection with the atomizer based on the handshake request signal, specifically including:

[0056] After the communication wire physically connects the nebulizer to the ventilator, the second microcontroller generates a handshake request signal and sends it to the nebulizer communication module through the asynchronous data transmission line, so that the nebulizer communication module sends the handshake request signal to the ventilator communication module of the ventilator through the transmission line of the serial communication interface. The first microcontroller receives the handshake request signal from the ventilator communication module and generates a handshake response signal, and sends the handshake response signal to the second microcontroller based on the ventilator communication module and the nebulizer communication module, so that after the first microcontroller and the second microcontroller shake hands successfully, a serial communication connection is established.

[0057] In other words, the ventilator and the nebulizer can establish a physical connection through a communication wire, and then the ventilator and the nebulizer can shake hands, thereby establishing a serial communication connection between the ventilator and the nebulizer. Specifically, when the nebulizer is connected to the ventilator through the cable of the communication wire, the second microcontroller of the nebulizer sends a handshake request signal to the nebulizer communication module through the transmission line of the universal asynchronous receiver / transmitter (UART), that is, the asynchronous data transmission line, wherein the nebulizer communication module can use a chip such as MAX232EESE model, or other types of communication chips can be used, and this application is not specifically limited to this. The nebulizer communication module can process the handshake request signal, such as data analysis, data conversion, data verification, protocol processing and compliance, and then send the handshake request signal to the receiving serial port of the ventilator communication module of the ventilator through the transmission line of the serial universal interface, and the ventilator communication module performs signal processing on the received handshake request signal. Among them, the ventilator communication module can use a communication chip such as the MAX3232 model, or other types of chips, which are not specifically limited in this application. Subsequently, the ventilator communication module sends a handshake request signal to the receiving serial port of the first microcontroller, and the first microcontroller generates a handshake response signal that feeds back the handshake request signal. The handshake response signal is sent to the UART receiving serial port of the second microcontroller via the first microcontroller, the sending serial port of the ventilator communication module, the receiving line of the serial communication interface of the nebulizer communication module, and the UART receiving line of the nebulizer communication interface, so that the nebulizer and the ventilator can shake hands successfully and establish a serial port communication connection between the first microcontroller and the second microcontroller, so as to control the nebulizer to work through the ventilator.

[0058] After establishing the above-mentioned serial communication connection, the second microcontroller also sends the nebulizer control protocol to the first microcontroller. The nebulizer control protocol at least includes the necessary instructions for the ventilator to control the nebulizer, such as various operating parameters of the nebulizer, working mode, start / stop instructions, etc. This application does not make specific limitations on this.

[0059] In the embodiment of the present application, after establishing a serial communication connection with the atomizer based on the handshake request signal, the method further includes:

[0060] The second microcontroller uses one of the following methods to disable the body control button of the atomizer:

[0061] The electrical connection between the key circuit corresponding to the body control key and the second microcontroller is disconnected. Alternatively, the instruction execution function of the body control key is disabled.

[0062] In other words, when the serial communication connection between the nebulizer and the ventilator is established, the button function of the nebulizer body itself becomes invalid, and the function of the nebulizer will be completely controlled by the ventilator. The second microcontroller may disconnect the electrical connection between the button circuit corresponding to the body control button and the second microcontroller, or continuously generate a signal that disables the command execution function of the body control button, so that the body control button becomes invalid, and this application does not make specific restrictions on this.

[0063] In one embodiment of the present application, the method further includes:

[0064] When the serial communication connection is disconnected, the second microcontroller generates a key control recovery signal and sends it to the key circuit of the atomizer to restore the control authority of the body control key.

[0065] In other words, when the second microcontroller receives a disconnection signal of the serial communication connection, the second microcontroller will generate a key control recovery signal to restore the body control key, and the second microcontroller can respond to the control signal of the body control key to control the atomizer to work.

[0066] in Figure 4 It is the button circuit of the atomizer. The button circuit is an ON / OFF interface directly connected to the second microcontroller. When SW1 is pressed, the ON / OFF pin level is pulled low, and the second microcontroller collects the signal to control the operation of the atomizer.

[0067] Through the above technical solution, the problem of users accidentally touching the nebulizer body button and causing abnormal nebulization when using the above ventilator to control the nebulizer can be avoided, thereby improving the stability of the nebulization control function based on the ventilator.

[0068] In an embodiment of the present application, the method further includes:

[0069] The first microcontroller obtains the operating status information of the nebulizer in real time through the serial communication connection, and displays the operating status information on the display screen of the ventilator. The operating status information at least includes the atomization water level state obtained by the water level detection module of the nebulizer and / or the battery power of the nebulizer.

[0070] That is to say, the display screen of the ventilator has a ventilator user interface (UI), which can display the operating status information of the nebulizer, including the atomization water level status, battery power, etc., and can also include alarm information, such as atomization water level alarm, battery power alarm, etc., which is not specifically limited in this application. Through the above scheme, the relevant information of the nebulizer can be timely understood with the help of the ventilator display screen, so as to facilitate timely intervention of atomization control.

[0071] In addition, the display screen may also include a breathing control area and a breathing parameter display area, wherein the breathing control area at least includes a nebulizer control control, and the breathing parameter display area at least includes patient breathing parameters; patient breathing parameters at least include: peak inspiratory pressure, tidal volume, leakage, minute ventilation, positive end-expiratory pressure PEEP, total respiratory rate, peak inspiratory flow, oxygen concentration, etc. This application does not make specific limitations on this.

[0072] In one embodiment of the present application, the atomization water level state can be obtained by:

[0073] The atomizer cup head is provided with a water level probe. When the liquid water level in the atomizer cup head is above the preset water level, the water level probe generates a stable signal, and the second microcontroller can detect the stable signal. At this time, the atomizer water level state is a water state. When the liquid water level is lower than the preset water level, the signal of the water level probe disappears. When the second microcontroller detects that the stable signal disappears, it will generate a water-free signal and send it to the first microcontroller to update the atomizer water level state to a water-free state.

[0074] refer to Figure 5 , Figure 5 This is the circuit schematic diagram corresponding to the water level detection module. T41 is connected to the water level probe and the mesh sheet drive circuit. When the water level probe has a signal transmitted from T41, the signal is rectified by diode D10 to turn the signal into a positive signal. Resistor R19 limits the current of the signal, and then the signal is clamped by diode D11 and diode D9, so that when there is water in the cup head, the signal at point AD3 is always stable at a fixed value, which is 4V. When there is no water in the water cup, the signal disappears, there is no signal at point AD3, and the voltage value is 0V. The second microcontroller only needs to detect the signal at point AD3 and set a threshold value for comparison. When the value of AD3 is higher than the threshold value, it works normally. When the value of AD3 is lower than the threshold value, the atomizer can be shut down without water.

[0075] In addition, the nebulizer of the present application may also include a battery power supply module and an adapter power supply module, and the power supply priority of the adapter power supply module is greater than the power supply priority of the battery power supply module; the ventilator also includes an output power supply line for connecting to the adapter power supply module to power the nebulizer.

[0076] That is to say, the atomizer of the present application can be powered by a battery or by an external power adapter. Figure 6 It is the power supply circuit of the atomizer, where VUSB 5V is powered by the adapter and VBAT1 is powered by the battery. Both power supply methods eventually supply power to VBAT+ to power the back-stage circuit of the atomizer. However, when the two power supply methods exist at the same time, VBAT1 is cut off through the Q2PMOS tube, and VUSB 5V is used alone for power supply. The role of diode D2 is to reduce the voltage of the adapter 5V, and D1 is to ensure that the Q2PMOS tube can be turned on. Among them, the ventilator can be provided with an output power supply line, which is connected to the VUSB 5V interface through the power supply line to power the atomizer.

[0077] S102, the first microcontroller determines the corresponding breathing stage of the patient according to the patient's breathing information from the breathing sensor.

[0078] In an embodiment of the present application, the ventilator can obtain the patient's respiratory information, such as the patient's respiratory rate, tidal volume, PEEP, etc., through its internal respiratory sensor. The first microcontroller can obtain the patient's respiratory cycle and the corresponding respiratory stage based on the patient's respiratory information. The respiratory stage includes the inspiratory phase and the expiratory phase in the respiratory cycle. The inspiratory phase can be understood as the stage in which the patient inhales air into the lungs, while the expiratory phase is the opposite, which is the stage in which the patient expels gas. The respiratory stage obtained by the first microcontroller may include the corresponding moments when the patient exhales and inhales next.

[0079] S103, after receiving the nebulization control instruction, the first microcontroller continuously generates the inhalation phase nebulization instruction and sends it to the second microcontroller according to the nebulizer control protocol before entering the inhalation phase in the breathing stage, so that the nebulizer can synchronize the nebulization with the air supply flow of the ventilator based on the preset delayed nebulization time and stop nebulization in the expiratory phase.

[0080] In the embodiment of the present application, after the ventilator is connected to the nebulizer, whether to perform nebulization can be controlled through the ventilator user interface. When the user clicks on the start of nebulization, the first microcontroller will obtain the nebulization control instruction so as to perform nebulization during the patient's inspiratory phase. Among them, the ventilator will issue the inspiratory phase nebulization instruction to the nebulizer through the nebulizer control protocol. The ventilator sends the inspiratory phase nebulization instruction to the second microcontroller before the patient is about to inhale, that is, before entering the inspiratory phase.

[0081] In the embodiment of the present application, the nebulizer performs synchronous misting with the air supply flow of the ventilator based on the preset delayed misting time, specifically including:

[0082] The second microcontroller determines the time of receiving the inhalation phase fogging instruction, and uses the time of receiving as the delay start time for timing. When the timing time reaches the preset delayed fogging time, a high-level pulse width modulation PWM signal is generated to drive the mesh sheet of the nebulizer to vibrate at the optimal working frequency point, so that when the air supply flow of the ventilator reaches the three-way interface position set at the atomizer cup head of the nebulizer, atomizing gas accompanying the air supply flow is generated to perform synchronous fogging.

[0083] That is to say, after receiving the inhalation phase fogging instruction, the second microcontroller will not immediately emit fog. The reason is that when the patient enters the inhalation phase, the air supply flow of the ventilator and the atomized gas of the nebulizer will reach the breathing mask synchronously under ideal conditions, and then enter the patient's lungs. There is a distance from the front end of the breathing pipe of the ventilator (the section connected to the ventilator interface) to the end of the breathing pipe (the end connected to the breathing mask). The three-way interface connected to the atomizer cup head of the nebulizer is set at the end of the breathing pipe (the end near the breathing mask, refer to Figure 2 ), if the nebulizer emits mist while the ventilator generates the air supply flow, the air supply flow has not reached the three-way interface of the respiratory duct at this time, and cannot effectively carry the atomized gas into the patient's body. Therefore, the present application sets a preset delay time for mist emission. When the second microcontroller receives the inhalation phase mist emission instruction, it counts the time, and after the preset delay time for mist emission, the second microcontroller generates a PWM signal to drive the mesh sheet of the nebulizer to vibrate at the optimal operating frequency point corresponding to its specifications, so that the nebulizer emits mist. At this time, the air supply flow reaches the three-way interface position, and the air supply flow carries the atomized gas into the patient's body, thereby realizing synchronous mist emission with the air supply flow.

[0084] For example, the ventilator monitors the patient's breathing rate and breathing status. When the patient inhales, the ventilator delivers oxygen. During the oxygen delivery process, it sends an inhalation phase mist instruction to the nebulizer. After the nebulizer receives the instruction from the ventilator, it takes action after 200 milliseconds (ms) to emit mist. The generated medicine is delivered to the patient's body along with the oxygen supply of the ventilator. When the patient exhales, the ventilator detects the patient's exhalation status, the ventilator gives instructions, and the nebulizer stops working. This reciprocating process achieves the effect of breathing following and improves the utilization rate of the nebulized liquid medicine. The above 200ms is the preset delay misting time. 200ms is only for example. In actual use, the preset delay misting time can be set by the user, and this application does not make specific limitations on this.

[0085] The above-mentioned preset delayed misting time is at least positively correlated with the length of the breathing tube of the ventilator. For example, the longer the breathing tube is, the longer the preset delayed misting time is, and the shorter the breathing tube is, the shorter the preset delayed misting time is.

[0086] Through the above technical solution, the nebulizer and the ventilator can work synchronously to generate an atomized airflow that accompanies the patient's breathing process. On the basis of ensuring the therapeutic effect of respiratory atomization, it can save more drug liquid resources and improve the patient's respiratory atomization experience, forming an efficient and coordinated respiratory atomization treatment system.

[0087] In one embodiment of the present application, in order to allow the mesh sheet to vibrate at an optimal operating frequency, the method further includes:

[0088] The second microcontroller controls the frequency sweep from the initial frequency of 90KHz, increasing by 1KHz each time, and determines the mesh sheet work efficiency characterization value corresponding to each frequency until the frequency sweep reaches the preset frequency value, so as to generate a signal frequency selection curve according to the work efficiency characterization value of each mesh sheet. The frequency sweep frequency corresponding to the minimum mesh sheet work efficiency characterization value in the signal frequency selection curve is used as the optimal working frequency point, so as to generate a corresponding PWM signal according to the optimal working frequency point, and control the mesh sheet to vibrate at the optimal working frequency point.

[0089] refer to Figure 7 , Figure 7 This is the circuit schematic diagram of the atomizer frequency sweep module. The atomizer frequency sweep module is connected to the mesh sheet drive circuit, and the mesh sheet drive voltage in the mesh sheet drive circuit is divided and sampled. The mesh sheet drive voltage VDD is divided and sampled and filtered, and then fed back to the A / D input terminal of the second microcontroller (the pin connected to AN3). The mesh sheet is used as the load of the secondary drive, and there are impedance differences between individuals. The fixed VDD voltage will show different voltages on different mesh sheets after passing through the secondary drive. Therefore, the fixed voltage cannot be applied to all mesh sheets, and the spray efficiency of the mesh sheet is directly related to the drive voltage. Therefore, in order to ensure that each mesh sheet can be provided with sufficient driving voltage to meet the requirements of the whole machine spray rate, the atomizer frequency sweeping module collects VDD voltage, and for different mesh sheet loads, outputs a duty cycle through PWM to give the mesh sheet an initial frequency of 90khz, and then increases it by 1Khz each time to achieve frequency sweeping. As the frequency changes, the working efficiency of the mesh sheet will change, and the voltage on R46 will change. However, the signal of the voltage change is very small at this time and cannot be collected. Therefore, the operational amplifier U9 is used to amplify this signal. At this time, the second microcontroller collects the voltage at AN3, which will form the following Figure 8 The voltage variation curve shown (the horizontal axis is frequency, the vertical axis is voltage / V) is the signal frequency selection curve. The vertical axis in the curve is the mesh sheet working efficiency characterization value. The minimum mesh sheet working efficiency characterization value is the best working frequency point of this mesh sheet. Therefore, when the atomizer generates a driving signal to drive the mesh sheet of this specification, it generates PWM at the frequency corresponding to the best working frequency point.

[0090] Through the above technical solution, a treatment system that combines a ventilator and a nebulizer and performs atomization control is realized. After the nebulizer and the ventilator are physically connected, the user can control the nebulizer through the ventilator, and can flexibly nebulize the mist according to the patient's real-time breathing information and the respiratory airflow, thereby ensuring the patient's atomization treatment effect and the utilization rate of the atomized medicine solution, while improving the user's experience of using the existing ventilator and nebulizer.

[0091] refer to Figure 2 A nebulizer control system based on a ventilator includes a ventilator and a nebulizer. The ventilator is provided with a display screen 201, a communication wire 202, a breathing tube 203, a first microcontroller, a three-way interface 204 arranged at the end of the breathing tube, and a breathing mask 205.

[0092] The display screen 201 includes a ventilator user interface, which includes a breathing control area and a breathing parameter display area. The breathing control area at least includes a nebulizer control control, and the breathing parameter display area at least includes patient breathing parameters. Patient breathing parameters include at least: peak inspiratory pressure, tidal volume, leakage, minute ventilation, positive end-expiratory pressure PEEP, total respiratory rate, peak inspiratory flow, and oxygen concentration. The communication wire 202 is used to connect the communication interface of the nebulizer to establish a serial communication connection with the nebulizer. The three-way interface 204 is used to communicate with the nebulizer cup head 208 of the nebulizer. The nebulizer host 206 of the nebulizer is connected to the nebulizer cup head 208 of the nebulizer through the nebulizer connecting line 207 (conductive connecting line).

[0093] The present application is based on a nebulization control system of a ventilator, and can perform a patient's breathing nebulization control through the following embodiments, including:

[0094] After the first microcontroller receives the handshake request signal from the second microcontroller, it establishes a serial communication connection with the nebulizer based on the handshake request signal to receive the nebulizer control protocol sent by the second microcontroller. The handshake request signal is generated based on the operation of the communication wire connected to the communication interface of the nebulizer. The nebulizer control protocol includes at least the required instructions for the ventilator to control the nebulizer. According to the patient's breathing information from the respiratory sensor, the corresponding breathing stage of the patient is determined. After receiving the nebulization control instruction, before the breathing stage enters the inhalation phase, according to the nebulizer control protocol, the inhalation phase fogging instruction is continuously generated and sent to the second microcontroller, so that the nebulizer is based on the preset delayed fogging time, accompanied by the air supply airflow of the ventilator to synchronize the fogging, and stop fogging in the expiratory phase.

[0095] Further, after the first microcontroller receives the handshake request signal from the second microcontroller, a serial communication connection with the atomizer is established based on the handshake request signal, specifically including:

[0096] After the communication wire physically connects the nebulizer to the ventilator, the second microcontroller generates a handshake request signal and sends it to the nebulizer communication module through the asynchronous data transmission line, so that the nebulizer communication module sends the handshake request signal to the ventilator communication module of the ventilator through the transmission line of the serial communication interface.

[0097] The first microcontroller receives a handshake request signal from the ventilator communication module and generates a handshake response signal, and sends the handshake response signal to the second microcontroller based on the ventilator communication module and the nebulizer communication module, so that after the first microcontroller and the second microcontroller handshake successfully, a serial communication connection is established.

[0098] Further, after establishing a serial communication connection with the atomizer based on the handshake request signal, the system further includes:

[0099] The second microcontroller uses one of the following methods to disable the body control button of the atomizer:

[0100] The electrical connection between the key circuit corresponding to the body control key and the second microcontroller is disconnected. Alternatively, the instruction execution function of the body control key is disabled.

[0101] The system also includes:

[0102] When the serial communication connection is disconnected, the second microcontroller generates a key control recovery signal and sends it to the key circuit of the atomizer to restore the control authority of the body control key.

[0103] Furthermore, the system also includes:

[0104] The first microcontroller obtains the operating status information of the nebulizer in real time through the serial communication connection, and displays the operating status information on the display screen of the ventilator. The operating status information at least includes the atomization water level state obtained by the water level detection module of the nebulizer and / or the battery power of the nebulizer.

[0105] Furthermore, the nebulizer performs synchronous misting with the air supply flow of the ventilator based on the preset delayed misting time, specifically including:

[0106] The second microcontroller determines the time of receiving the inhalation phase fogging instruction, and uses the time of receiving as the delay start time for timing. When the timing time reaches the preset delayed fogging time, a high-level pulse width modulation PWM signal is generated to drive the mesh sheet of the nebulizer to vibrate at the optimal working frequency point, so that when the air supply flow of the ventilator reaches the three-way interface position set at the atomizer cup head of the nebulizer, atomizing gas accompanying the air supply flow is generated to perform synchronous fogging.

[0107] Furthermore, the system also includes:

[0108] The second microcontroller controls the frequency sweep from the initial frequency of 90KHz, increasing by 1KHz each time, and determines the mesh sheet work efficiency characterization value corresponding to each frequency until the frequency sweep reaches the preset frequency value, so as to generate a signal frequency selection curve according to the work efficiency characterization value of each mesh sheet. The frequency sweep frequency corresponding to the minimum mesh sheet work efficiency characterization value in the signal frequency selection curve is used as the optimal working frequency point, so as to generate a corresponding PWM signal according to the optimal working frequency point, and control the mesh sheet to vibrate at the optimal working frequency point.

[0109] Furthermore, the preset delayed misting time is at least positively correlated with the length of the breathing tube of the ventilator.

[0110] In one embodiment of the present application, the atomizer further includes a water level detection module. The water level detection module is respectively connected to the atomizer cup head and the second microcontroller, and is used to generate a waterless state signal and send it to the second microcontroller when the water level of the atomizer cup head is lower than a preset water level, so that the second microcontroller sends a waterless state signal to the first microcontroller through a communication wire, so as to update the atomization water level state on the display screen to a waterless state, and enable the first microcontroller to control the atomizer to stop responding to the inhalation phase mist supply instruction.

[0111] In one embodiment of the present application, the nebulizer further comprises a battery power supply module and an adapter power supply module, and the power supply priority of the adapter power supply module is greater than the power supply priority of the battery power supply module. The ventilator further comprises an output power supply line for connecting to the adapter power supply module to power the nebulizer.

[0112] Each embodiment in this application is described in a progressive manner, and the same or similar parts between the embodiments can be referred to each other, and each embodiment focuses on the differences from other embodiments. In particular, for the system embodiment, since it is basically similar to the method embodiment, the description is relatively simple, and the relevant parts can be referred to the partial description of the method embodiment.

[0113] The system and method provided in the embodiment of the present application correspond one to one, and therefore the system also has similar beneficial technical effects as its corresponding method. Since the beneficial technical effects of the method have been described in detail above, the beneficial technical effects of the system will not be repeated here.

[0114] It should also be noted that the terms "include", "comprises" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, commodity or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, commodity or device. In the absence of more restrictions, the elements defined by the sentence "comprises a ..." do not exclude the existence of other identical elements in the process, method, commodity or device including the elements.

[0115] The above is only the embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various changes and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application should be included in the scope of the claims of the present application.

Claims

1. A nebulization control method based on a ventilator, characterized in that: The method comprises: After receiving the handshake request signal from the second microcontroller, the first microcontroller establishes a serial communication connection with the nebulizer based on the handshake request signal, so as to receive the nebulizer control protocol sent by the second microcontroller; wherein the handshake request signal is generated based on the operation of connecting the communication wire to the communication interface of the nebulizer; the nebulizer control protocol at least includes the instructions required for the ventilator to control the nebulizer; Determine the corresponding respiratory stage of the patient according to the patient's respiratory information from the respiratory sensor; After receiving the nebulization control instruction, before the breathing stage enters the inhalation phase, the inhalation phase nebulization instruction is continuously generated and sent to the second microcontroller according to the nebulizer control protocol, so that the nebulizer can synchronize the nebulization with the air supply flow of the ventilator based on the preset delayed nebulization time and stop nebulization in the expiratory phase.

2. A nebulization control method based on a ventilator according to claim 1, characterized in that: After the first microcontroller receives the handshake request signal from the second microcontroller, the first microcontroller establishes a serial communication connection with the atomizer based on the handshake request signal, specifically including: After the communication wire physically connects the nebulizer to the ventilator, the second microcontroller generates the handshake request signal and sends it to the nebulizer communication module through the asynchronous data transmission line, so that the nebulizer communication module sends the handshake request signal to the ventilator communication module of the ventilator through the transmission line of the serial communication interface; The first microcontroller receives the handshake request signal from the ventilator communication module and generates a handshake response signal, and sends the handshake response signal to the second microcontroller based on the ventilator communication module and the nebulizer communication module, so that the serial port communication connection is established after the first microcontroller and the second microcontroller successfully handshake.

3. A nebulization control method based on a ventilator according to claim 1, characterized in that: After establishing a serial communication connection with the atomizer based on the handshake request signal, the method further includes: The second microcontroller disables the body control button of the atomizer by one of the following methods: Disconnecting the electrical connection between the key circuit corresponding to the body control key and the second microcontroller; disabling the command execution function of the body control button; The method further comprises: When the serial communication connection is disconnected, the second microcontroller generates a key control recovery signal and sends it to the key circuit of the atomizer to restore the control authority of the body control key.

4. A nebulization control method based on a ventilator according to claim 1, characterized in that: The method further comprises: The first microcontroller obtains the operating status information of the nebulizer in real time through the serial port communication connection, and displays the operating status information on the display screen of the ventilator; the operating status information at least includes the atomization water level status obtained by the water level detection module of the nebulizer and / or the battery power of the nebulizer.

5. A nebulization control method based on a ventilator according to claim 1, characterized in that: The nebulizer performs synchronous misting with the air supply flow of the ventilator based on the preset delayed misting time, specifically including: The second microcontroller determines the reception time of the inhalation phase mist instruction, and uses the reception time as the delay start time for timing; When the timing time reaches the preset delayed mist discharge time, a high-level pulse width modulation (PWM) signal is generated to drive the mesh sheet of the nebulizer to vibrate at the optimal operating frequency point, so that when the air supply flow of the ventilator reaches the three-way interface position set at the atomizing cup head of the nebulizer, atomizing gas accompanying the air supply flow is generated to perform synchronous mist supply.

6. A nebulization control method based on a ventilator according to claim 5, characterized in that: The method further comprises: The second microcontroller controls the frequency sweep from an initial frequency of 90KHz, increasing by 1KHz each time, and determines the mesh sheet working efficiency characterization value corresponding to each frequency until the sweep frequency reaches a preset frequency value, so as to generate a signal frequency selection curve according to each mesh sheet working efficiency characterization value; The sweep frequency corresponding to the minimum mesh sheet working efficiency characterization value in the signal frequency selection curve is used as the optimal working frequency point, so as to generate the corresponding PWM signal according to the optimal working frequency point to control the mesh sheet to vibrate at the optimal working frequency point.

7. A nebulization control method based on a ventilator according to claim 5, characterized in that: The preset delayed misting time is at least positively correlated with the breathing tube length of the ventilator.

8. A nebulizer control system based on a ventilator, characterized in that: The system comprises a ventilator and a nebulizer; the ventilator is provided with a display screen, a communication wire, a breathing tube, a first microcontroller, a three-way interface arranged at the end of the breathing tube, and a breathing mask; The display screen includes a ventilator user interface, which includes a breathing control area and a breathing parameter display area, wherein the breathing control area includes at least atomization control controls, and the breathing parameter display area includes at least patient breathing parameters; the patient breathing parameters include at least: peak inspiratory pressure, tidal volume, leakage, minute ventilation, positive end-expiratory pressure PEEP, total respiratory rate, peak inspiratory flow, and oxygen concentration; The communication wire is used to connect to the communication interface of the atomizer to establish a serial communication connection with the atomizer; the three-way interface is used to communicate with the atomizer cup head of the atomizer; The system performs a patient's breathing aerosol control by means of a ventilator-based aerosol control method as described in any one of claims 1-7.

9. A nebulizer control system based on a ventilator according to claim 8, characterized in that: The atomizer also includes a water level detection module; The water level detection module is respectively connected to the atomizer cup head and the second microcontroller, and is used to generate a water-free status signal and send it to the second microcontroller when the water level of the atomizer cup head is lower than a preset water level, so that the second microcontroller sends the water-free status signal to the first microcontroller through the communication wire, so as to update the atomization water level status in the display screen to a water-free status, and enable the first microcontroller to control the atomizer to stop responding to the inhalation phase mist supply instruction.

10. A nebulization control system based on a ventilator according to claim 8, characterized in that: The atomizer further comprises a battery power supply module and an adapter power supply module, and the power supply priority of the adapter power supply module is greater than the power supply priority of the battery power supply module; The ventilator also includes an output power supply line for connecting to the adapter power module to power the nebulizer.

Images