Compound, polymer, gel dressing, and preparation method and application thereof

Abstract

The invention provides a functional monomer as shown in a formula (I), a preparation method thereof, gel prepared from the functional monomer as a raw material, a gel dressing and application of the gel dressing. According to the invention, polyvinyl alcohol, polyglutamic acid and acrylic acid are taken as gel raw materials, sodium chloride is taken as an effective component, an initiator and a cross-linking agent are added, a disulfide bond-containing compound as shown in the formula (I) is grafted, an interpenetrating gel network is formed, and the prepared gel dressing can be quickly attached to the skin and can also be easily and thoroughly removed from the surface of the skin. The gel dressing solves the problem of poor compliance of a patient, is adhered to an affected part of verruca vulgaris during use, is simple and convenient, does not contain preservatives, has no toxic or side effect on a human body, and is safe and reliable. Experimental results show that the gel dressing provided by the invention can be quickly attached to the skin and form stable adhesion, and after wart disappears, the gel dressing can be easily and thoroughly separated from the skin under the action of sodium bicarbonate and glutathione. # imgabs0 #

Description

Technical Field

[0001] The present invention relates to the technical field of medical materials, and in particular to a compound, a polymer, a gel dressing, a preparation method thereof and applications thereof. Background Art

[0002] Common warts are benign skin tumors caused by human papillomavirus (HPV) infection. They are most common on the fingers, toes, soles of feet and backs of hands. They are contagious and have a high recurrence rate. The current method for treating common warts is to destroy the warts as the main means, and the goal of treatment is to remove the warts.

[0003] The prior art (52 cases of common warts treated by immersion in saturated saline) discloses soaking or wet compressing common warts with an appropriate amount of saturated saline once a day for 30 minutes each time. After 4 weeks of observation, the total effective rate is 100%. This method mainly relies on the dehydration effect of sodium chloride ions, which leads to a high osmotic pressure environment in the wart body, and the host cells may be damaged or dysfunctional, thereby affecting the virus replication process, virus stability, transmission and infection ability. However, this method requires soaking or wet compressing, which is inconvenient in operation. Summary of the invention

[0004] In view of this, the present invention provides a compound, a polymer, a gel dressing, a preparation method and an application thereof. The gel dressing provided in the present application is easy to use, can be quickly adhered to the skin, and can be easily detached from the skin after the treatment is completed.

[0005] The present application provides a functional monomer shown in formula (I):

[0006]

[0007] The present application also provides a method for preparing a functional monomer represented by formula (I), comprising the following steps:

[0008] 1,4,5-oxydithioxane-2,7-dione and 2-hydroxyethyl methacrylate react under the action of an organic base to obtain a dithiocarboxylate compound represented by formula (1);

[0009]

[0010] The dithiocarboxylate compound represented by formula (1) reacts with N,N'-carbonyldiimidazole to obtain a functional monomer represented by formula (I);

[0011]

[0012] The present application also provides a gel, which is prepared from polyvinyl alcohol, acrylic acid, polyglutamic acid, a compound represented by formula (I), an initiator and a cross-linking agent:

[0013]

[0014] In some specific implementations, the mass ratio of the polyvinyl alcohol, acrylic acid, polyglutamic acid, the compound represented by formula (I), the initiator and the cross-linking agent is 1-20:10-50:0.1-1:0.1-5:0.1-1:0.01-1.

[0015] In some specific implementations, the initiator is selected from at least one of α-ketoglutaric acid, α-hydroxyphosphate, peroxide, xylyl ketone, benzoyl propanedione and benzoyl ethyl dione;

[0016] The cross-linking agent is selected from at least one of polyethylene glycol methacrylate, dimethacrylate glycol, epoxy acrylate, polyvinyl pyrrolidone and epoxy vinyl ether;

[0017] The number average molecular weight of the polyvinyl alcohol is 50,000 to 1,000,000 Daltons.

[0018] The present application also provides a gel dressing, comprising a gel prepared from polyvinyl alcohol, acrylic acid, polyglutamic acid, a compound represented by formula (I), an initiator and a cross-linking agent, and sodium chloride loaded in the gel:

[0019]

[0020] In some specific implementations, the mass ratio of the polyvinyl alcohol, acrylic acid, polyglutamic acid, the compound represented by formula (I), initiator, cross-linking agent and sodium chloride is 1-20:10-50:0.1-1:0.1-5:0.1-1:0.01-1:5-25.

[0021] In some specific implementations, the initiator is selected from at least one of α-ketoglutaric acid, α-hydroxyphosphate, peroxide, xylyl ketone, benzoyl propanedione and benzoyl ethyl dione;

[0022] The cross-linking agent is selected from at least one of polyethylene glycol methacrylate, dimethacrylate glycol, epoxy acrylate, polyvinyl pyrrolidone and epoxy vinyl ether;

[0023] The number average molecular weight of the polyvinyl alcohol is 50,000 to 1,000,000 Daltons.

[0024] In some specific implementations, the gel dressing further includes a protective layer composited on the gel.

[0025] Use of the gel described in the above technical solution and / or the gel dressing described in the above technical solution in the preparation of drugs for treating common warts and / or antibacterial and bacteriostatic drugs.

[0026] The present application uses polyvinyl alcohol, polyglutamic acid and acrylic acid as gel raw materials, sodium chloride as an effective ingredient, adds an initiator and a cross-linking agent, and grafts the compound shown in formula (I) containing a disulfide bond to form an interpenetrating gel network. The prepared gel dressing can quickly adhere to the skin after absorbing water through hydrogen bonds and electrostatic interactions. Subsequently, the compound shown in formula (I) in the gel dressing can form a stable covalent amide bond with the amine group in the skin, stably adhere to the skin, and the sodium chloride ions in the gel contact the common wart wound surface with water molecules, resulting in a high osmotic pressure environment, thereby affecting the virus replication process, the stability, transmission and infection ability of the virus; the gel contains a disulfide bond, and when the sodium chloride ions inside the gel are completely released, the dissociation solution containing sodium bicarbonate and glutathione can be used to break the disulfide bond, so that the gel dressing can be easily and thoroughly removed from the skin surface. The gel dressing solves the problem of poor patient compliance. When used, the gel dressing can be attached to the common wart affected area. It is simple and convenient, does not contain preservatives, is completely non-toxic and side effects to the human body, and is safe and reliable. In addition, the gel dressing provided by the present application has a good bactericidal effect. The experimental results show that the gel dressing provided by the present application can be quickly attached to the skin and form stable adhesion, and after the wart disappears, it can be easily and completely detached from the skin under the action of sodium bicarbonate and glutathione. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying creative work.

[0028] Figure 1 The present invention provides the principle and method of using the gel dressing provided in this application. DETAILED DESCRIPTION

[0029] It should be understood that the expression "one or more of..." includes each of the items recited after the expression individually and in various different combinations of two or more of the recited items, unless otherwise understood from the context and usage. The expression "and / or" in combination with three or more recited items should be understood to have the same meaning, unless otherwise understood from the context.

[0030] The use of the terms "comprising", "having" or "containing", including their grammatical synonyms, should generally be understood as open and non-restrictive, for example not excluding other unrecited elements or steps, unless otherwise specifically stated or otherwise understood from the context.

[0031] It should be understood that the order of steps or the order in which certain actions are performed is not important as long as the present invention remains operable. In addition, two or more steps or actions may be performed simultaneously.

[0032] The use of any and all examples or exemplary language, such as "for example" or "including", herein is intended only to better illustrate the invention and does not limit the scope of the invention unless otherwise claimed. No language in this specification should be construed as indicating that any non-claimed element is essential to the practice of the invention.

[0033] In addition, the numerical ranges and parameters used to define the present invention are approximate values, and the relevant values ​​in the specific embodiments have been presented as accurately as possible. However, any numerical value inherently inevitably contains standard deviations due to individual test methods. Therefore, unless otherwise expressly stated, it should be understood that all ranges, quantities, values ​​and percentages used in this disclosure are modified by "about". Here, "about" generally means that the actual value is within plus or minus 10%, 5%, 1% or 0.5% of a specific value or range.

[0034] The present application provides a functional monomer shown in formula (I):

[0035]

[0036] The functional monomer shown in formula (I) is an N,N'-carbonyldiimidazole compound containing a disulfide bond, which can react with the primary amine groups on the skin surface to form an amide bond, thereby firmly adhering to the skin surface; at the same time, the disulfide bond can be broken under the action of sodium bicarbonate and L-glutathione, and can be easily and completely detached from the skin surface.

[0037] The present application also provides a method for preparing a functional monomer represented by formula (I), comprising the following steps:

[0038] 1,4,5-oxydithioxane-2,7-dione and 2-hydroxyethyl methacrylate react under the action of an organic base to obtain a dithiocarboxylate compound represented by formula (1);

[0039]

[0040] The dithiocarboxylate compound represented by formula (1) reacts with N,N'-carbonyldiimidazole to obtain a functional monomer represented by formula (I);

[0041]

[0042] The present application uses 1,4,5-oxydithiohexane-2,7-dione and 2-hydroxyethyl methacrylate as raw materials, reacts under the action of an organic base, and obtains a dithiocarboxylate compound shown in formula (1). Among them, 1,4,5-oxydithiohexane-2,7-dione and 2-hydroxyethyl methacrylate are both commercially available raw materials, and the present application has no special restrictions on their sources. In some specific implementations, the mass ratio of the 1,4,5-oxydithiohexane-2,7-dione and 2-hydroxyethyl methacrylate is 1:1 to 5, preferably 1:1.2. In some specific implementations, the organic base includes but is not limited to 4-dimethylaminopyridine, triethylamine, N,N-dimethylacetamide, etc., and can be one or more of them. When the organic base is a combination of multiple specific substances, the present application has no special restrictions on the proportion of each substance. In some specific implementations, the reaction is carried out in a solvent, including but not limited to dichloromethane, carbon tetrachloride, dimethyl ether, benzene, etc., preferably dichloromethane. In some specific implementations, the reaction is preferably carried out at room temperature, and the reaction time is preferably 10h to 30h.

[0043] After the reaction is completed, the obtained reaction product is acidified, extracted, dried, concentrated, and purified to obtain the dithiocarboxylate compound represented by formula (1). The present application has no special requirements for the acidification, extraction, drying, concentration, and purification, and those skilled in the art can select them according to their needs.

[0044] After obtaining the dithiocarboxylate compound shown in formula (1), it is reacted with N,N'-carbonyldiimidazole to obtain the acyl imidazole compound shown in formula (I). In some specific implementations, the mass ratio of the dithiocarboxylate compound shown in formula (1) to N,N'-carbonyldiimidazole is 1:1-2, preferably 1:1.5. In some specific implementations, the reaction is carried out in a solvent, and the solvent includes but is not limited to dichloromethane, chloroform, dimethylsulfamide, acetonitrile, etc., preferably dichloromethane. In some specific implementations, the reaction is preferably carried out at room temperature, and the reaction time is preferably 10h to 30h.

[0045] After the reaction is completed, the obtained reaction product is purified to obtain the acyl imidazole compound represented by formula (I). The present application has no particular limitation on the purification, and the purification can be performed by using a chromatographic column with a mixture of dichloromethane and methanol as an eluent.

[0046] The present application also provides a gel, which is prepared from polyvinyl alcohol, acrylic acid, polyglutamic acid, a compound represented by formula (I), an initiator and a cross-linking agent:

[0047]

[0048] The present application uses polyvinyl alcohol, acrylic acid, polyglutamic acid and the compound shown in formula (I) as raw materials. Under the action of an initiator and a crosslinking agent, polyvinyl alcohol, acrylic acid and polyglutamic acid are grafted with the compound shown in formula (I) to form an interpenetrating gel network, which can be used as a gel dressing.

[0049] In some specific implementations, the mass ratio of the polyvinyl alcohol, acrylic acid, polyglutamic acid, the compound represented by formula (I), the initiator and the cross-linking agent is 1-20:10-50:0.1-1:0.1-5:0.1-1:0.01-1, preferably 5-15:15-45:0.2-0.9:0.5-3:0.2-0.9:0.05-0.8.

[0050] The gel raw material provided by the present application includes polyvinyl alcohol, which is the main component for forming the gel, and its number average molecular weight is preferably 500,000 to 1,000,000 Daltons, and more preferably 100,000 to 900,000 Daltons. The gel raw material provided by the present application includes acrylic acid, and acrylic acid and polyvinyl alcohol are copolymerized to form a gel network. The gel raw material provided by the present application includes polyglutamic acid, which can enhance the moisture content of the gel and load more sodium chloride. The gel raw material provided by the present application includes a compound shown in formula (I), which will not be repeated in this application.

[0051] The gel raw material provided in the present application also includes an initiator. In some specific implementations, the initiator is selected from at least one of α-ketoglutaric acid, α-hydroxyphosphate, peroxide, xylyl ketone, benzoyl propanedione and benzoyl ethyl ketone. When the initiator is multiple of them, the present application has no special restrictions on the proportion of each specific substance.

[0052] The gel raw material provided in the present application also includes a cross-linking agent. In some specific implementations, the cross-linking agent is selected from at least one of polyethylene methacrylate, dimethacrylate glycol, epoxy acrylate, polyvinyl pyrrolidone and epoxy vinyl ether. When the initiator is multiple of them, the present application has no special restrictions on the proportion of each specific substance.

[0053] The present application has no special restrictions on the preparation method of the gel. Polyvinyl alcohol, acrylic acid, polyglutamic acid crosslinking agent and initiator are mixed in a first solvent to obtain a reaction stock solution; the compound represented by formula (I) is dissolved in an organic solvent and mixed with the reaction stock solution to obtain a precursor liquid; the precursor liquid is cured to obtain a gel dressing. In some specific implementations, the first solvent is selected from deionized water, and the organic solvent is selected from acetone. In some specific implementations, the curing is preferably ultraviolet curing, the wavelength is preferably 280nm to 320nm, and the power is preferably 10W to 120W.

[0054] The present application also provides a gel dressing, comprising a gel prepared from polyvinyl alcohol, acrylic acid, polyglutamic acid, a compound shown in formula (I), an initiator and a cross-linking agent, and sodium chloride loaded in the gel. Compared with the gel, the gel dressing provided by the present application loads sodium chloride in the gel, making the gel dressing more suitable for treating diseases such as common warts.

[0055] In some specific implementations, the mass ratio of the polyvinyl alcohol, acrylic acid, polyglutamic acid, the compound represented by formula (I), initiator, cross-linking agent and sodium chloride is 1-20:10-50:0.1-1:0.1-5:0.1-1:0.01-1:5-25, preferably 5-15:15-45:0.2-0.9:0.5-3:0.2-0.9:0.05-0.8:10-20.

[0056] In the gel dressing, other components are the same as those described above and will not be described in detail in this application.

[0057] The preparation method of the gel dressing is different from that of the gel in that sodium chloride is simultaneously mixed into the stock solution when the raw materials are mixed, and the other steps and parameters are basically the same, which will not be described in detail in this application.

[0058] In some specific implementations, the gel dressing further includes a protective layer composited on the gel.

[0059] The gel provided in the present application and / or the gel dressing described in the above technical solution can be used to treat common warts and / or antibacterial and antimicrobial drugs.

[0060] The use principle of the gel dressing provided in this application is as follows Figure 1 As shown, Figure 1 The principle and method of use of the gel dressing provided in this application, wherein Figure 1 (a) is a schematic diagram of attaching the gel dressing to the skin. Figure 1 (b) is a schematic diagram of the release of sodium chloride ions after the gel dressing is attached to the skin. Figure 1 (c) is a schematic diagram of removing the gel dressing using a dissociation solution. The gel dressing provided in the present application can quickly adhere to the skin after absorbing water through hydrogen bonds and electrostatic interactions, and then the compound shown in formula (I) in the gel dressing can form a stable covalent amide bond with the amine group in the skin, etc., and stably adhere to the skin. The sodium chloride ions in the gel contact the common wart wound surface with the water molecules, resulting in a high osmotic pressure environment, thereby affecting the virus replication process, the stability, transmission and infection ability of the virus; the gel contains disulfide bonds, and when the sodium chloride ions in the gel are completely released, the dissociation solution containing sodium bicarbonate and glutathione can break the disulfide bonds, thereby easily and thoroughly removing the gel dressing from the skin surface.

[0061] The present application also provides a dissociation solution, including sodium bicarbonate, glutathione and phosphate buffer. The present application has no special restrictions on the phosphate buffer, preferably a phosphate buffer with a pH of 7 to 7.4. In some specific implementations, the concentration of the sodium bicarbonate is 5 to 15 g / mL, preferably 8 to 10 g / mL; the concentration of the glutathione is 0.5 to 3 g / mL, preferably 1 to 2.5 g / mL. The dissociation solution is used to dissociate the gel dressing described above from the skin surface.

[0062] The gel dressing provided in the present application also has bactericidal and antibacterial functions and can be used for wound treatment.

[0063] The present application uses polyvinyl alcohol, polyglutamic acid and acrylic acid as gel raw materials, sodium chloride as an effective ingredient, adds an initiator and a cross-linking agent, and grafts a compound represented by formula (I) containing a disulfide bond. The prepared gel dressing can be quickly attached to the skin surface and treat common warts by releasing sodium chloride; and the gel contains a disulfide bond, which can be broken under the action of sodium bicarbonate and glutathione so that the gel can be easily detached from the skin. Experimental results show that the gel dressing provided by the present application can be quickly attached to the skin, and after the wart disappears, it can be easily and completely detached from the skin under the action of sodium bicarbonate and glutathione.

[0064] The compounds, gels, gel dressings, preparation methods and applications thereof provided in the present application are further described below in conjunction with the examples.

[0065] Example 1

[0066] 1.5 g of 1,4,5-oxodithioxane-2,7-dione oil was transferred into a mixture of 1.9 g 2-hydroxyethyl methacrylate, 12 mg 4-dimethylaminopyridine and 15 mL anhydrous dichloromethane, stirred overnight at room temperature, and 30 ml of saturated sodium bicarbonate solution was added to complete the reaction. Then, the mixture was acidified to pH = 2 with 1 M HCl, extracted with dichloromethane, the organic phase was dried over sodium sulfate, and concentrated under reduced pressure. The crude product was purified in a chromatographic column using a mixture of methanol and dichloromethane as the eluent to obtain the dithiocarboxylate compound represented by formula (1);

[0067]

[0068] 1.08 g of the purified product was dissolved in 30 mL of anhydrous dichloromethane, and stirred with 1.5 g of CDI (N,N'-carbonyldiimidazole) to react overnight to obtain a crude product; the crude product was purified using a mixture of dichloromethane and methanol in a volume ratio of 85:15 as an eluent to obtain an acyl imidazole compound represented by formula (I):

[0069]

[0070] Example 2 Preparation of gel dressing

[0071] Step (1) Preparation of a gel solution with sodium chloride:

[0072] Dissolve 7% (w / v) polyvinyl alcohol, 35% (w / v) acrylic acid, 5% (w / v) sodium chloride, 0.5% (w / v) polyglutamic acid, 0.2% (w / v) α-ketoglutaric acid and 0.03% (w / v) polyethylene glycol methacrylate in deionized water to obtain a stock solution;

[0073] Step (2) Grafting disulfide bonds:

[0074] 100 mg of the acyl imidazole compound of formula (2) prepared in Example 1 was dissolved in acetone, and 10 mL of the stock solution obtained in step (1) was added to obtain a precursor solution;

[0075] Step (3) Curing:

[0076] Pour the precursor solution prepared in step (2) onto the mold, and cure it under ultraviolet light with a wavelength range of 280 nm to 320 nm and a power of 100 W to obtain a gel;

[0077] Step (4) uses:

[0078] The gel obtained in step (3) is applied to the wart body of common warts and continuously moistened until the sodium chloride is completely released. The gel provided in the present application can be quickly attached to the skin surface. On the second day after the application, the wart body of common warts begins to dry, desquamate, and gradually shrink in size until the wart body completely disappears, thereby achieving the treatment of common warts.

[0079] Prepare the dissociation solution: dissolve 9.585 g of sodium bicarbonate and 1.5366 g of glutathione in 100 mL of phosphate buffer respectively to obtain the dissociation solution; when the gel dressing is in a dry state or a contracted state, use the dissociation solution to remove the gel dressing, and the gel is completely separated from the skin without any residue.

[0080] Example 3 Preparation of gel dressing:

[0081] The difference from Example 2 is that the proportions of the raw materials in step (1) are different, specifically: 7% (w / v) polyvinyl alcohol, 35% (w / v) acrylic acid, 10% (w / v) sodium chloride, 0.5% (w / v) polyglutamic acid, 0.2 (w / v) α-ketoglutaric acid and 0.03% (w / v) polyethylene glycol methacrylate. The other steps are the same.

[0082] Example 4 Preparation of gel dressing:

[0083] The difference from Example 2 is that the proportions of the raw materials in step (1) are different, specifically: 7% (w / v) polyvinyl alcohol, 35% (w / v) acrylic acid, 18% (w / v) sodium chloride, 0.5% (w / v) polyglutamic acid, 0.2% (w / v) α-ketoglutaric acid and 0.03% (w / v) polyethylene glycol methacrylate. The other steps are the same.

[0084] Test Example 1

[0085] Test bacteria: Staphylococcus aureus (ATCC 6538), Escherichia coli (ATCC 25922).

[0086] Experimental methods:

[0087] Take a culture dish, pour the culture medium into it, wait for it to solidify and lay it flat, then pour the culture medium of the soaking solution of the gel dressings of Examples 1, 2, and 3 respectively, and evenly spread the selected bacteria on it after solidification. Then place the culture dish in a 37°C incubator, observe the growth of the bacteria after culturing for 24 hours, and determine the concentration range in which Examples 1, 2, and 3 have an inhibitory effect on the bacteria. The results are shown in Table 1, which shows the antibacterial test results of the gel dressings of Examples 1 to 3.

[0088] Table 1 Antibacterial test results of the gel dressings of Examples 1 to 3

[0089]

[0090] It can be seen from Table 1 that the gel dressing provided by the present invention has a good antibacterial effect.

[0091] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. Functional monomer represented by formula (I):

2. A method for preparing the functional monomer represented by formula (I), comprising the following steps: 1,4,5-oxydithioxane-2,7-dione and 2-hydroxyethyl methacrylate react under the action of an organic base to obtain a dithiocarboxylate compound represented by formula (1); The dithiocarboxylate compound represented by formula (1) reacts with N,N'-carbonyldiimidazole to obtain a functional monomer represented by formula (I); 3. A gel prepared from polyvinyl alcohol, acrylic acid, polyglutamic acid, a compound represented by formula (I), an initiator and a cross-linking agent:

4. The gel according to claim 3, characterized in that The mass ratio of the polyvinyl alcohol, acrylic acid, polyglutamic acid, the compound represented by formula (I), the initiator and the crosslinking agent is 1-20:10-50:0.1-1:0.1-5:0.1-1:0.01-1.

5. The gel according to claim 3, characterized in that The initiator is selected from at least one of α-ketoglutaric acid, α-hydroxyphosphate, peroxide, xylyl ketone, benzoyl propanedione and benzoyl ethyl dione; The cross-linking agent is selected from at least one of polyethylene glycol methacrylate, dimethacrylate glycol, epoxy acrylate, polyvinyl pyrrolidone and epoxy vinyl ether; The number average molecular weight of the polyvinyl alcohol is 50,000 to 1,000,000 Daltons.

6. A gel dressing, comprising a gel prepared from polyvinyl alcohol, acrylic acid, polyglutamic acid, a compound represented by formula (I), an initiator and a cross-linking agent, and sodium chloride loaded in the gel:

7. The gel dressing according to claim 6, characterized in that: The mass ratio of the polyvinyl alcohol, acrylic acid, polyglutamic acid, the compound represented by formula (I), initiator, crosslinking agent and sodium chloride is 1-20:10-50:0.1-1:0.1-5:0.1-1:0.01-1:5-25.

8. The gel dressing according to claim 6, characterized in that: The initiator is selected from at least one of α-ketoglutaric acid, α-hydroxyphosphate, peroxide, xylyl ketone, benzoyl propanedione and benzoyl ethyl dione; The cross-linking agent is selected from at least one of polyethylene glycol methacrylate, dimethacrylate glycol, epoxy acrylate, polyvinyl pyrrolidone and epoxy vinyl ether; The number average molecular weight of the polyvinyl alcohol is 50,000 to 1,000,000 Daltons.

9. The gel dressing according to claim 6, characterized in that: Also included is a protective layer composited on the gel.

10. Use of the gel according to any one of claims 3 to 5 and / or the gel dressing according to any one of claims 6 to 9 in the preparation of a drug for treating common warts and / or for antibacterial and bacteriostatic effects.

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