Composition for treating alopecia as well as application and preparation method thereof

Abstract

The invention relates to the field of traditional Chinese medicine compositions, and particularly discloses a composition for treating alopecia and a preparation method thereof. The invention aims to solve the problems that the problem of alopecia is more and more common at present, and a medicine for treating alopecia is low in treatment effective rate and easy to relapse, and particularly provides a composition for treating alopecia, which comprises ethanol with the ethanol content of 85-92%.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine compositions, and in particular to a composition for treating hair loss and a preparation method thereof. Background Art

[0002] As the natural environment of human survival becomes increasingly harsh, fierce market competition, increasingly complex work pressure, and complicated interpersonal relationships make people feel the pressure of life. Alopecia areata and thinning hair have become common phenomena in society. The problem of hair loss is becoming more and more common and has become one of the factors affecting the self-confidence of many people. Let everyone have black and shiny hair is a topic that hairdressing researchers have been trying to solve.

[0003] Traditional methods of treating hair loss include medication, hair transplant surgery, and laser therapy. Among medications, minoxidil is currently more popular in the market and is suitable for both men and women. Minoxidil was originally developed as a blood pressure lowering drug, but was later found to promote hair growth by dilating blood vessels, increasing blood flow to the scalp, and stimulating hair follicles to enter the growth phase. Market verification has shown that minoxidil can be applied to the top of the head and forehead areas, but minoxidil still has the problem of low treatment efficiency, and the effect varies from person to person. Some people can clearly see thickening and growth of hair after use, but some people do not see obvious results after use. Moreover, minoxidil needs to be used continuously to maintain its effects. After stopping the drug, the new hair may fall off again. Summary of the invention

[0004] The purpose of the present invention is to solve the problem that hair loss is becoming more and more common, and the drug treatment for hair loss has low efficacy and is prone to recurrence. Specifically, a composition for treating hair loss, its application and its preparation method are provided.

[0005] The basic technical solution of the present invention is: a composition for treating hair loss, comprising ethanol, and the ethanol content is between 85% and 90%.

[0006] The ethanol content is 85% to 90%, which refers to the concentration of ethanol in the processed and prepared combination dosage form product, and does not refer to the concentration of ethanol in the processed and prepared raw materials.

[0007] The inventors found in their research that compositions with ethanol concentrations above 65% have significantly better therapeutic effects on hair loss than compositions with ethanol content below 65%. Components below 65% have almost no effect, and compositions with concentrations of 85% to 90% can meet the needs, with a concentration of 90% having the best therapeutic efficacy.

[0008] As we all know, alcohol has a bactericidal effect. On the one hand, it can cause protein denaturation in microbial cells, and on the other hand, it can dissolve lipid components such as lipid membranes of microorganisms, destroy cell membranes, and thus prevent microbial reproduction. It is generally believed that 70%-75% ethanol concentration has the best bactericidal effect. However, high-concentration alcohol is not as effective as low-concentration alcohol in killing bacteria. The reason is that high-concentration alcohol has high volatility and can quickly dry the surface. When high-concentration alcohol contacts microorganisms, it can quickly coagulate proteins on the surface of microorganisms to form a protective film. This film prevents alcohol from further penetrating into the interior of the microorganism, limiting its bactericidal effect. In terms of fat dissolving, the fat dissolving effect is also greatly reduced due to the effect of the protective film. Therefore, it is generally believed that the optimal concentration of alcohol for sterilization is 70-75%.

[0009] However, during the research process of the present invention, the inventors found that the effect of treating hair loss with an alcohol concentration of 85%-90% is much better than that with an alcohol concentration of 70%-75%. The reason for this is that, in the process of the composition of the present invention contacting the scalp, according to the principle of like dissolves like, the high concentration of alcohol quickly dries the scalp surface, wraps up the grease and harmful bacteria, and inhibits the continued reproduction of microorganisms; the effective ingredients in the composition activate the hair follicles, effectively kill harmful bacteria such as Malassezia on the scalp surface, stimulate the hair follicles, and promote regeneration. After multiple uses, the composition of the present invention gradually purifies the hair follicles, improves the scalp environment, reduces hair loss, and promotes new hair growth.

[0010] Furthermore, the composition for treating hair loss has an ethanol content of 90%. The concentration of medical alcohol is 95%. The composition product of the present invention is prepared using 95% medical alcohol, and the final ethanol concentration of the final product is 90%, which is the easiest to obtain and has the best effect. Therefore, the ethanol concentration of 90% is the best choice.

[0011] Furthermore, based on the above alcohol concentration, the composition for treating hair loss of the present invention comprises raw materials including psoralea corylifolia, polygonum multiflorum, eclipta prostrata, arborvitae leaves, indigo naturalis, peach kernel, black sesame, sunflower seed, terminalia chebula, and iron powder.

[0012] The inventors have found through research that scalp follicle spasm is a common phenomenon among people with hair loss. Scalp follicle spasm refers to local blood circulation disorders caused by excessive pressure or nervous tension, increased capillary permeability, and accumulation of fluid in the interstitial space to form edema. The swelling usually occurs in the top of the head, feels soft, and there is local hair loss for a short period of time, with no symptoms or accompanied by erythema.

[0013] Common ways to solve hair follicle spasm type hair loss are to use Chinese medicine prescriptions to promote blood circulation and remove blood stasis, supplement nutrition, inhibit bacteria and reduce inflammation, or use external minoxidil gel, hair growth cream and other drugs for treatment, which helps to relieve discomfort symptoms, but cannot cure it. Usually, hair loss patients take finasteride tablets orally under the guidance of doctors, or acupuncture, hair transplantation, autologous hair follicle transplantation, hair transplantation surgery, and the treatment methods are relatively painful and cannot cure it. The Chinese medicine formula of the present invention focuses on solving alopecia areata and hair loss caused by hair follicle spasm, and can effectively solve the problems of long treatment course, low cure rate, large side effects and patients' inability to judge the treatment effect in time in the existing alopecia areata treatment methods. At the same time, according to volunteer trials, the present invention also has obvious effects in preventing hair loss and improving hair quality.

[0014] Psoralea corylifolia: antibacterial, anti-inflammatory, improves acne, repairs skin barrier, and promotes melanin production; Platycladus orientalis leaves: promote the conversion of male hormones into female hormones, promote hair growth, and contain a variety of hair colors; Polygonum multiflorum: replenishes essence and blood, blackens hair, strengthens tendons and bones, nourishes liver and kidney, and improves sleep; Eclipta prostrata: provides black hair pigments, which can dilate coronary blood vessels, increase coronary flow and increase the ability to tolerate hypoxia. The effects appear quickly and last for a long time. Indigo: clearing away heat and detoxifying, reducing swelling and dispersing blood stasis, treating skin diseases, mumps and hemorrhagic diseases; Peach kernel: antibacterial, prevents and treats acne, promotes cell growth, and has a hair growth effect; Black sesame: replenishes kidney yang, improves blood essence, activates tyrosinase, and increases melanin; Terminalia chebula: Antioxidant, can increase the ATP content in the dermal papilla cells of human hair follicles, enhance cell activity, help resist external environmental stimulation, reduce sensitivity, repair and prevent scalp damage, improve scalp barrier, nourish the scalp, and enhance scalp health.

[0015] The ethanol in the present invention wraps up the grease and harmful bacteria on the scalp, inhibits the continued reproduction of microorganisms, cleans the grease and residues in the pores, utilizes the synergistic effects of Eclipta prostrata, Indigo naturalis and Psoralea corylifolia on detumescence and blood stasis, antibacterial and anti-inflammatory, and muscle relaxation, relieves hair follicle spasm, and utilizes the absorption and utilization of active repair ingredients such as Platycladus orientalis leaves, Polygonum multiflorum, Eclipta prostrata and Bakuchiol; at the same time, the iron powder is absorbed by the scalp, which helps to increase the oxygen content of local blood and nourish the hair follicles and hair roots. Under the synergistic effect of various components, multiple problems causing local hair loss are effectively solved.

[0016] And the inventor has followed up for a long time, and found that there is no recurrence after stopping the drug. Compared with other drugs such as Nordil, it does not need to be used continuously.

[0017] Furthermore, the composition for treating hair loss comprises 5-30 parts of psoralea corylifolia, 1-10 parts of polygonum multiflorum, 10-50 parts of eclipta prostrata, 10-30 parts of oriental arborvitae leaves, 5-30 parts of indigo naturalis, 5-30 parts of peach kernel, 1-10 parts of black sesame, 3-15 parts of terminalia chebula, and 0.1-3 parts of iron powder.

[0018] Further, a composition for treating hair loss, wherein the raw materials include 20 parts of psoralea corylifolia, 5 parts of polygonum multiflorum, 20 parts of eclipta prostrata, 15 parts of orientalis leaves, 10 parts of indigo naturalis, 15 parts of peach kernel, 6 parts of black sesame, 10 parts of terminalia chebula, and 1-3 parts of iron powder; Or: 25 parts of psoralea corylifolia, 6 parts of polygonum multiflorum, 20 parts of eclipta prostrata, 15 parts of orientalis leaves, 15 parts of indigo naturalis, 10 parts of peach kernel, 5 parts of black sesame, 9 parts of terminalia chebula, 1 part of iron powder; Or: 25 parts of psoralea corylifolia, 5 parts of polygonum multiflorum, 25 parts of eclipta prostrata, 10 parts of orientalis leaves, 10 parts of indigo naturalis, 15 parts of peach kernel, 3 parts of black sesame, 5 parts of terminalia chebula, and 2 parts of iron powder; Or: 20 parts of Psoralea corylifolia, 10 parts of Polygonum multiflorum, 15 parts of Eclipta prostrata, 20 parts of Platycladus orientalis, 20 parts of Indigo naturalis, 5 parts of Semen persica, 5 parts of Sesame nigrum, 10 parts of Terminalia chebula, and 0.5 part of iron powder.

[0019] The raw materials of the present invention can be used to prepare a composition dosage product according to the above ratio, which can effectively improve hair loss after use.

[0020] The composition for treating hair loss has iron powder as nano iron powder. Nano iron powder is more conducive to scalp absorption, improves the oxygen content of local blood in the scalp, is more conducive to nourishing hair follicles and hair roots, and promotes the growth of new hair.

[0021] The application of the above composition in the preparation of pharmaceutical preparations, the preparation is a tincture. The most advantageous preparation for the present invention may be a tincture, which is applied to the part of hair loss when the scalp is dry, and has a higher absorption rate, and there will be no drug loss compared to other dosage forms. Of course, if it is made into dosage forms such as lotions, pastes, liniments, sprays, etc., it will not affect the use effect of the present invention, but for example, lotions will lose their efficacy after being washed after a short period of contact with the scalp; the ductility of pastes and liniments is weaker than that of tinctures, and the convenience of application is slightly weaker; and during the spraying process, the spray cannot avoid drug loss, and the utilization rate is reduced. Taking all factors into consideration, tincture is the best dosage form, but other dosage forms do not affect the efficacy, and only the time of use needs to be adjusted according to the actual effect.

[0022] The above composition is used as an auxiliary medicine for promoting hair growth.

[0023] The high concentration of ethanol in the composition of the present invention is the core point of the present invention for treating hair loss. Long-term use of high concentration ethanol gradually purifies hair follicles and improves the scalp environment, so that the scalp can fully absorb other drugs in the composition. Therefore, as the core point of the present invention, it can not only be used in combination with the components in the raw materials of the present invention to achieve a very good effect in treating hair loss; in market applications, it can also be used in combination with other drugs that promote hair growth, such as Yangyuanqing, by adding ethanol to the product until the ethanol concentration reaches 90%.

[0024] The method for preparing the above-mentioned pharmaceutical preparation adopts alcohol extraction, and the alcohol extraction time is 10 to 15 days.

[0025] Alcohol extraction is to use ethanol to extract the effective ingredients of the composition. Compared with other extraction methods, since the effective ingredients of most compositions are fat-soluble, using ethanol as a solvent can effectively dissolve the effective ingredients and improve the extraction efficiency; furthermore, alcohol extraction is carried out in a low temperature environment, so a large amount of active ingredients can be preserved; and since ethanol has a good bactericidal and antibacterial effect, alcohol extraction can reduce the generation of impurities, prevent the growth of microorganisms, and facilitate storage and transportation. In addition, the product of the present invention requires a high final concentration of ethanol, so alcohol extraction is the best choice.

[0026] Ethanol is commonly used as an extraction solvent and is generally used in a concentration of 50% to 70% for the extraction and preparation of effective components, while the ethanol concentration used in the present invention is as high as 95%. The use of high-concentration ethanol can catalyze the fusion and conversion of components between the components and increase the extraction efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 This is a trial effect diagram of a typical case 1 in Embodiment 7 of the present invention; Figure 2 This is a trial effect diagram of typical case 2 in embodiment 7 of the present invention; Figure 3 This is a trial effect diagram of typical case 3 in embodiment 7 of the present invention; Figure 4 This is a trial effect diagram of typical case 4 in embodiment 7 of the present invention. DETAILED DESCRIPTION

[0028] The following is further described in detail through specific implementation methods: Embodiment 1: Weigh 200g of Psoralea corylifolia, 50g of Polygonum multiflorum, 200g of Eclipta prostrata, 150g of Platycladus orientalis, 100g of Indigo naturalis, 150g of Peach kernel, 60g of Black sesame, and 100g of Terminalia chebula; The mixture was mixed and ground, passed through a 20-mesh sieve, 30 g of nano iron powder was added to the mixed powders to prepare a mixture for treating hair loss, and the mixture was soaked in 3.12 L of 95% medical ethanol at room temperature for 15 days, filtered, and the composition of the present invention was obtained, i.e., the essence. The final concentration of ethanol was found to be 90%.

[0029] Embodiment 2: Weigh 250g of Psoralea corylifolia, 60g of Polygonum multiflorum, 200g of Eclipta prostrata, 150g of Platycladus orientalis, 150g of Indigo naturalis, 100g of Peach kernel, 50g of Black sesame, and 90g of Terminalia chebula; The mixture was mixed and ground, passed through a 20-mesh sieve, 10 g of nano iron powder was added to the mixed powders to prepare a mixture for treating hair loss, and the mixture was soaked in 3.2 L of 95% medical ethanol at room temperature for 15 days, filtered, and the composition of the present invention was obtained, i.e., the essence. The final concentration of ethanol was found to be 91%.

[0030] Embodiment three: Weigh 250g of Psoralea corylifolia, 50g of Polygonum multiflorum, 250g of Eclipta prostrata, 100g of Platycladus orientalis, 100g of Indigo naturalis, 150g of Peach kernel, 30g of Black sesame, and 50g of Terminalia chebula; The mixture was mixed and ground, passed through a 20-mesh sieve, 20 g of nano iron powder was added to the mixed powders to prepare a mixture for treating hair loss, and the mixture was soaked in 3 L of 95% medical ethanol at room temperature for 15 days, filtered, and the composition of the present invention was obtained, i.e., the essence. The final concentration of ethanol was found to be 91%.

[0031] Embodiment 4: Weigh 200g of Psoralea corylifolia, 100g of Polygonum multiflorum, 150g of Eclipta prostrata, 200g of Platycladus orientalis, 200g of Indigo naturalis, 50g of Peach kernel, 50g of Black sesame, and 100g of Terminalia chebula; The mixture was mixed and ground, and passed through a 20-mesh sieve. After mixing the above powders, 5 g of nano iron powder was added to obtain a mixture for treating hair loss. The mixture was soaked in 3.16 L of 95% medical ethanol at room temperature for 15 days, and filtered to obtain the composition of the present invention, which is the essence. The final concentration of ethanol was found to be 92%.

[0032] The above are only examples of the raw material ratio, ethanol dosage, and preparation method of the composition of the present invention. The component dosages of each embodiment can be arbitrarily combined, such as the dosage of some components in Example 1, the dosage of some components in Example 2, the dosage of some components in Example 3, and the dosage of some components in Example 4. For example, 250g of Psoralea corylifolia, 50g of Polygonum multiflorum, 150g of Eclipta prostrata, 150g of Platycladus orientalis, 100g of Indigo naturalis, 150g of Peach Kernel, 60g of Black Sesame, 50g of Terminalia chebula, and 20g of nano iron powder. There are more examples, which are not listed here. Similarly, mixed and ground, after passing through a 20-mesh sieve, 3 times the amount of 95% medical ethanol is weighed and soaked at room temperature for about two weeks, and then the final concentration of ethanol is detected to be between 90-92, and the composition of the present invention with high efficiency in treating hair loss can be obtained. Of course, if the concentration is lower than 90%, alcohol can be added to between 90 and 92.

[0033] Example 5: Verification of the effect of the present invention in treating hair loss 1. Sample The sample of the present invention is the composition obtained in Example 1 of the present invention; Positive control sample: 100 bottles of 5% minoxidil tincture were purchased from JD flagship store as a positive control; Placebo: Prepare 100 bottles of purified water as blank control.

[0034] The above compositions are all packaged into 90 ml / bottles for standby use.

[0035] 2. Trial Patients The trial patients of the present invention were sourced from the dermatology departments of Lintao XX Tibetan Medicine Hospital and Lanzhou XX Tibetan Medicine Hospital, which are cooperative hospitals of the applicant of the present invention.

[0036] There are three common hair conditions: (1) The hair is sparsely shed, but the progression is slow. It can be stable at a certain level for a long time and will not continue to develop. It will recover on its own after a period of time. (2) Hair loss occurs in patches, which is called focal alopecia or alopecia areata. (3) The process of hair loss progressing from sparse or patchy loss to complete hair loss is called total alopecia or alopecia totalis.

[0037] Sparse shedding is more common, followed by alopecia areata, and then total shedding. Regardless of whether it is alopecia areata or total shedding, Chinese medicine calls it "oil wind". Alopecia areata is a mild condition, while total shedding is a severe condition.

[0038] Method: 150 patients with hair loss who met the above criteria were selected and randomly divided into 3 groups. The treatment group was treated with the composition of the sample of the present invention (containing 90% ethanol), the blank control group was treated with a placebo, and the positive control group was treated with minoxidil tincture. A course of treatment was 6 months. The symptoms before and after treatment were recorded, the number of hair loss of the patients was observed, and the efficacy of the drug was evaluated.

[0039] Treatment group: 50 cases, including 30 males and 20 females; aged 8 to 60 years, average 31 years; disease course 30 days to 6 years; including 7 cases within 1 year, 10 cases 1 to 3 years, and 33 cases 3 to 6 years; 32 cases of alopecia areata, 10 cases of total alopecia, and 8 cases of sparse hair.

[0040] Placebo group: 50 cases, including 25 males and 25 females; aged 20 to 57 years, average 33 years; disease course 30 days to 6 years; including 10 cases within 1 year, 15 cases 1 to 3 years, and 25 cases 3 to 6 years; 30 cases of alopecia areata, 11 cases of alopecia totalis, and 9 cases of sparse hair.

[0041] Positive control group: 50 cases, including 23 males and 27 females; aged 18 to 55 years, average 30 years; disease course 30 days to 6 years; 7 cases within 1 year, 8 cases from 1 to 3 years, 35 cases from 3 to 6 years; 27 cases of alopecia areata, 11 cases of total alopecia, and 12 cases of sparse hair.

[0042] Among them, it is particularly noted that there is an 8-year-old patient in the treatment group, who is a special volunteer. Since the patient suffers from severe alopecia areata and has been treated in many hospitals but has not been able to obtain good treatment effects, he had no choice but to participate in the treatment experiment of the present invention.

[0043] 3. Treatment Methods Treatment group: Apply the sample of the present invention to the bald scalp, alopecia areata scalp or thinning hair area once a day in the morning and evening. The treatment group is treated for 3 months / 6 months continuously to determine the efficacy.

[0044] Placebo group: Apply purified water (90ml / bottle) to the bald scalp, alopecia areata scalp or sparse hair area once in the morning and evening every day. The placebo group was treated for 3 months / 6 months to determine the efficacy.

[0045] Positive control group: Minoxidil tincture (90ml / bottle) was applied to the bald scalp, alopecia areata scalp or sparse hair area once in the morning and evening every day. The efficacy was determined after 3 months / 6 months of continuous treatment.

[0046] IV. Efficacy results, as shown in Table 1: Table 1

[0047] Therapeutic efficacy criteria: cure means that the hair in the bald area has completely grown back to the same size as normal hair after 6 months of use; marked effect means that more than 60% of the new hair is close to normal hair after 3 months of use; effective means that less than 60% of the new hair, including vellus hair, is black or white in color after 3 months of use; ineffective means that no new hair grows after 3 months of observation.

[0048] As can be seen from Table 1, there is a significant difference in the total effective rate between the treatment group and the positive control group. During the use of the composition of the present invention, except for mild local irritation in individual cases, no other side effects were observed. It should be noted that after the treatment group was cured for 6 months and followed up for 2 years, no case of recurrence of hair loss was found.

[0049] Example 6: Verification of the efficacy of compositions with different final ethanol concentrations 1. Sample preparation Sample 1 (90% ethanol final concentration): the composition obtained in Example 1 of the present invention; Sample 2 (85% ethanol final concentration): The raw material components are the same as those in Example 1, and the difference between the preparation method and Example 1 is that 90% of the medical ethanol raw material is used to soak the mixture to obtain a composition with a final ethanol concentration of about 85%; Sample 3 (65% ethanol final concentration): The raw material components are the same as those in Example 1, and the difference between the preparation method and Example 1 is that 70% of the medical ethanol raw material is used to soak the mixture to obtain a composition with a final ethanol concentration of about 65%; Sample 4 (45% ethanol final concentration): The raw material components are the same as those in Example 1, and the difference between the preparation method and Example 1 is that 50% of the medical ethanol raw material is used to soak the mixture to obtain a composition with a final ethanol concentration of about 45%; Sample 5 (25% ethanol final concentration): The raw material components are the same as those in Example 1, and the difference between the preparation method and Example 1 is that 30% of the medical ethanol raw material is used to soak the mixture to obtain a composition with a final ethanol concentration of about 25%; The above compositions are all packaged into 90 ml / bottles for standby use.

[0050] The configuration method of ethanol concentration in the present invention is: ① To prepare 1L of 30% ethanol, the volume of 95% ethanol required is: V=30000 / 95=316ml; take 316ml of 95% ethanol solution, add purified water to make up to 1L, and obtain a 30% ethanol solution.

[0051] ② To prepare 1L of 50% ethanol, the volume of 95% ethanol required is: V=50000 / 95=526ml; take 526ml of 95% ethanol solution, add purified water to make up to 1L, and obtain 50% ethanol solution.

[0052] ③ To prepare 1L of 70% ethanol, the volume of 95% ethanol required is: V=70000 / 95=736ml; take 736ml of 95% ethanol solution, add purified water to make up to 1L to obtain 70% ethanol solution.

[0053] ④ To prepare 1L of 90% ethanol, the volume of 95% ethanol required is: V=90000 / 95=947ml; take 947ml of 95% ethanol solution, add purified water to make up to 1L to obtain 90% ethanol solution.

[0054] ⑤95% ethanol solution is a commercially available ethanol solution.

[0055] It is worth noting that when preparing each composition, the final ethanol concentration of the product obtained each time has a deviation of 1-2%, which is considered to be within the normal range. For example, when the mixture is soaked in 95% ethanol, the final ethanol concentration of the composition obtained is usually between 90 and 92, most of which are 91%, and there are also final concentrations of 92%. Similarly, during the experiment, the final ethanol concentration of the composition prepared each time will also produce such an error. This error does not affect the therapeutic effect of the present invention.

[0056] 2. Volunteer Trial The volunteer selection criteria are consistent with those in Example 5; Methods: In this example, 250 patients were selected and randomly divided into 5 groups for trial. One group was coated with sample 1 (90% ethanol final concentration), the second group was coated with sample 2 (85% ethanol final concentration), the third group was coated with sample 3 (65% ethanol final concentration), the fourth group was coated with sample 4 (45% ethanol final concentration), and the fifth group was coated with sample 5 (25% ethanol final concentration).

[0057] One group: 50 cases, including 32 males and 18 females; aged 21 to 65 years, average 40 years; disease course 30 days to 6 years; 11 cases within 1 year, 10 cases 1 to 3 years, 29 cases 3 to 6 years; 28 cases of alopecia areata, 10 cases of total alopecia, 12 cases of sparse hair.

[0058] Group 2: 50 cases, including 25 males and 25 females; aged 20 to 56 years, average 34 years; course of disease 30 days to 6 years; 10 cases within 1 year, 15 cases from 1 to 3 years, 25 cases from 3 to 6 years; 31 cases of alopecia areata, 10 cases of total alopecia, 9 cases of sparse hair; Group 3: 50 cases, including 24 males and 26 females; aged 18 to 58 years, average 31 years; course of disease 30 days to 6 years; 7 cases within 1 year, 10 cases 1 to 3 years, 33 cases 3 to 6 years; 29 cases of alopecia areata, 10 cases of total alopecia, 11 cases of sparse hair; Group 3: 50 cases, including 23 males and 27 females; aged 20 to 55 years, average 30 years; course of disease 30 days to 6 years; 10 cases within 1 year, 8 cases from 1 to 3 years, 32 cases from 3 to 6 years; 27 cases of alopecia areata, 10 cases of total alopecia, 13 cases of sparse hair; Group 3: 50 cases, including 25 males and 25 females; aged 18 to 55 years, average 30 years; disease course 30 days to 6 years; 9 cases within 1 year, 10 cases 1 to 3 years, 31 cases 3 to 6 years; 30 cases of alopecia areata, 11 cases of total alopecia, 9 cases of sparse hair.

[0059] 3. Treatment Methods Each group of trials used samples from each group, and applied them to the bald scalp, alopecia areata scalp or sparse hair area once in the morning and evening every day. The treatment group was treated for 3 months / 6 months to determine the efficacy.

[0060] IV. Efficacy results, as shown in Table 2: Table 2

[0061] The efficacy evaluation criteria are consistent with those in Example 5.

[0062] As can be seen from Table 2, the total effective rates of Samples 1 and 2 are significantly different from those of Samples 3 to 5. Therefore, on this basis, the inventors of the present invention determined that the higher the concentration of ethanol, the more obvious the effect.

[0063] It should be noted that although the inventors here mark the final ethanol concentration of the sample as a certain number, such as 90%, 85%, and 65%, however, during the production process, due to the concentration error after the composition is soaked in high concentration ethanol, it is generally believed that it is higher than the marked concentration, such as 90% ethanol final concentration, the actual final ethanol concentration of the product is between 90%-92, and in most cases it is 91%; 85% ethanol final concentration, the actual final ethanol concentration of the product is between 85%-87, and in most cases it is 86%; 65% ethanol final concentration, the actual final ethanol concentration of the product is between 65%-67, and in most cases it is 66%; therefore, it can be considered that the optimal final ethanol concentration is between 90% and 92%, and the effect is still relatively significant between 85% and 87%; below 67%, it is considered to be ineffective.

[0064] Example 7: Typical case I. Typical Case 1 Subject: male, 60 years old, hair loss problem: sparse hair on the top of the head, with white hair. The sample of Example 1 of the present invention was tried, and the treatment period was 3 months (during use) / 6 months (after use). The effect of use: the hair volume increased significantly, the color was black, and the white hair decreased. Figure 1 shown.

[0065] 2. Typical Case 2 Subject: male, age 52, hair loss problem: from patchy hair loss to large-area local hair loss. The sample of Example 1 of the present invention was tried, and the treatment period was 3 months (during use) / 6 months (after use). The effect of use was: the hair volume increased significantly, and the hair in the local hair loss area grew again, such as Figure 2 shown.

[0066] 3. Typical Case 3 Subject: female, age 43, hair loss problem: sparse hair in the hairline area on the top of the head. The sample of Example 1 of the present invention was tried, and the treatment period was 3 months (during use) / 6 months (after use). The effect of use: the hair volume in the hairline area on the top of the head increased significantly, such as Figure 3 shown.

[0067] IV. Typical Case 4 Subject: female, age 45, hair loss problem: alopecia areata on the back of the head. The sample of Example 1 of the present invention was tried, and the treatment period was 3 months (during use) / 6 months (after use). The effect of use was: new hair grew in the alopecia areata area, the alopecia areata area gradually became smaller and finally returned to normal. Figure 4 shown.

[0068] The above is only an embodiment of the present invention, and the common knowledge such as the known specific structure and characteristics in the scheme is not described in detail here. It should be pointed out that for those skilled in the art, several deformations and improvements can be made without departing from the structure of the present invention. These should also be regarded as the scope of protection of the present invention, which will not affect the effect of the implementation of the present invention and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. A composition for treating hair loss, characterized in that: Contains ethanol, and the ethanol content is between 85% and 92%.

2. The composition according to claim 1, characterized in that: The ethanol content is 90-92%.

3. The composition according to claim 2, characterized in that: Its raw materials include psoralea corylifolia, polygonum multiflorum, eclipta prostrata, arborvitae leaves, indigo, peach kernel, black sesame, terminalia chebula, and iron powder.

4. The composition according to claim 3, characterized in that: The raw materials include 5-30 parts of psoralea corylifolia, 1-10 parts of polygonum multiflorum, 10-50 parts of eclipta prostrata, 10-30 parts of oriental arborvitae leaves, 5-30 parts of indigo naturalis, 5-30 parts of peach kernel, 1-10 parts of black sesame, 3-15 parts of terminalia chebula and 0.1-3 parts of iron powder.

5. The composition according to claim 4, characterized in that: The raw materials include 20 parts of psoralea corylifolia, 5 parts of polygonum multiflorum, 20 parts of eclipta prostrata, 15 parts of orientalis leaves, 10 parts of indigo naturalis, 15 parts of peach kernel, 6 parts of black sesame, 10 parts of terminalia chebula, and 1-3 parts of iron powder; Or: 25 parts of psoralea corylifolia, 6 parts of polygonum multiflorum, 20 parts of eclipta prostrata, 15 parts of orientalis leaves, 15 parts of indigo naturalis, 10 parts of peach kernel, 5 parts of black sesame, 9 parts of terminalia chebula, 1 part of iron powder; Or: 25 parts of psoralea corylifolia, 5 parts of polygonum multiflorum, 25 parts of eclipta prostrata, 10 parts of orientalis leaves, 10 parts of indigo naturalis, 15 parts of peach kernel, 3 parts of black sesame, 5 parts of terminalia chebula, and 2 parts of iron powder; Or: 20 parts of Psoralea corylifolia, 10 parts of Polygonum multiflorum, 15 parts of Eclipta prostrata, 20 parts of Platycladus orientalis, 20 parts of Indigo naturalis, 5 parts of Semen persica, 5 parts of Sesame nigrum, 10 parts of Terminalia chebula, and 0.5 part of iron powder.

6. The composition according to any one of claims 3 to 5, characterized in that: The iron powder is nano iron powder.

7. Use of the composition according to any one of claims 1 to 5 in the preparation of a pharmaceutical preparation, characterized in that: The preparation is a tincture.

8. Use of the composition according to claim 1 or 2 as an auxiliary drug for promoting hair growth.

9. A method for preparing the pharmaceutical preparation according to claim 7, characterized in that: Using alcohol extraction.

10. The method according to claim 9, characterized in that: The alcohol extraction time is 10 to 15 days.

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