Preparation device of chiral 3-hydroxyhexanoic acid

Abstract

The invention relates to the technical field of chiral 3-hydroxyhexanoic acid preparation, in particular to a chiral 3-hydroxyhexanoic acid preparation device which comprises a heating part, a mixing tank, a supporting part, an extraction tank, a supporting part and a bottom plate, the heating part comprises a plurality of heating rods and connecting rings, a first rotating shaft is arranged in the mixing tank, a plurality of first stirring rods are arranged on the outer side of the first rotating shaft, and a plurality of second stirring rods are arranged on the outer side of the first stirring rods; a protective cover is arranged above the mixing tank, a mixing motor is arranged on the protective cover, a first rotating shaft is driven by the mixing motor, a discharging pipe is arranged below the mixing tank, a filtering mechanism is arranged below the discharging pipe, and a collecting barrel is arranged on the bottom plate. And automatic production can be realized, and manual intervention is reduced, so that the production efficiency is improved, the production efficiency and the product quality are further improved, the rejection rate and the rework rate can be reduced, and the production cost is further reduced.

Description

Technical Field

[0001] The invention relates to the technical field of preparation of chiral 3-hydroxyhexanoic acid, and in particular to a preparation device of chiral 3-hydroxyhexanoic acid. Background Art

[0002] Polyhydroxyalkanoate (PHA) is a carbon source and energy storage material synthesized by bacteria under unbalanced growth conditions. It has been found that up to 150 R-configuration 3-hydroxy fatty acids, 4-hydroxy fatty acids, 5-hydroxy fatty acids and other monomers can be used as components of PHA. Hydroxy fatty acids contain both hydroxyl and carboxyl groups in their structure, which are prone to intramolecular and intermolecular polymerization to form PHA. PHA not only shows the properties of chemically synthesized plastics, but also has special properties such as good biodegradability and biocompatibility, and has broad application prospects. 3-Hydroxyhexanoic acid, as a monomer of PHA, is not only of great value in studying the performance of PHA, but also can play a regulatory role in the physiological activities of the body as a medicinal substance. However, there are few methods for preparing 3-hydroxyhexanoic acid monomers in the prior art, which are mainly based on the degradation of polymers. However, the process flow of this preparation method is complicated, and the purity of the obtained 3-hydroxyhexanoic acid is low.

[0003] The prior art patent CN112831530A discloses a method for preparing chiral 3-hydroxyhexanoic acid. The design aims to solve the problem that the prior art can only obtain 3-hydroxyhexanoic acid by degradation of polymer PHA, resulting in high production cost and complicated preparation process. The technical scheme of the design provides an enzymatic method for preparing 3-hydroxyhexanoic acid and salts, which uses methyl propionylacetate as a raw material, uses ketoreductase to reduce chiral 3-hydroxyhexanoic acid methyl ester, and further alkaline hydrolysis to obtain chiral 3-hydroxyhexanoic acid. The design method has the beneficial effects of low cost, simple process flow and high purity of the obtained 3-hydroxyhexanoic acid.

[0004] However, the device structure used in the preparation process in the above structure is too simple, which makes it easy to cause unstable product quality and low production efficiency during the preparation process. Summary of the invention

[0005] The purpose of the present invention is to provide a device for preparing chiral 3-hydroxyhexanoic acid, so as to solve the technical problem that the device structure used in the preparation process of the above structure in the prior art is too simple, which makes it easy to have unstable product quality and low production efficiency during the preparation process.

[0006] To achieve the above-mentioned object, the present invention provides a preparation device for chiral 3-hydroxyhexanoic acid, comprising a heating element, a mixing tank, a supporting element, an extraction tank, a lifting element and a bottom plate, wherein the heating element comprises a plurality of heating rods and a connecting ring, a first rotating shaft is arranged in the mixing tank, a plurality of first stirring rods are arranged on the outside of the first rotating shaft, a protective cover is arranged above the mixing tank, a mixing motor is arranged on the protective cover, and the mixing motor drives the first rotating shaft, a discharge pipe is arranged below the mixing tank, a filtering mechanism is arranged below the discharge pipe, a collecting bucket is arranged on the bottom plate, a plurality of the heating rods are respectively fixedly connected to the connecting ring and are located below the connecting ring, the connecting ring is fixedly connected to the mixing tank by bolts and is located on the mixing tank, and a plurality of the heating rods extend to the inner wall of the mixing tank, the mixing tank is arranged at one end of the bottom plate through the supporting element, the extraction tank is arranged at the other end of the bottom plate through the lifting element, and the extraction tank is also located directly below the filtering mechanism.

[0007] A feed pipe and a temperature sensor are arranged above the mixing tank, and an observation glass 117 and a timer are arranged outside the mixing tank.

[0008] Wherein, a material receiving pipe and a liquid inlet pipe are arranged above the extraction tank, a vibration motor is arranged outside the extraction tank, a discharge pipe is arranged below the extraction tank, and the collection bucket is located directly below the discharge pipe.

[0009] Among them, the preparation device of chiral 3-hydroxyhexanoic acid also includes multiple auxiliary stirring components, the auxiliary stirring components include a driven gear and a second rotating shaft, a plurality of second stirring rods are arranged on the outside of the second rotating shaft, a driving gear is arranged on the first rotating shaft, the driven gear is fixedly connected to the second rotating shaft and is located on the second rotating shaft, the second rotating shaft is rotatably connected to the mixing tank and is located in the mixing tank, the driving gear is meshed with the driven gear, and the driving gear and the driven gear are both located in the protective cover.

[0010] Wherein, the second rotating shaft is arranged around the outer side of the first rotating shaft, and the second stirring rod is located between the corresponding two first stirring rods.

[0011] Wherein, the support member includes a support rod and an F-shaped rod, the support rod is fixedly connected to the F-shaped rod and is located on the F-shaped rod, and the support rod is also arranged at one end of the bottom plate, the F-shaped rod is fixedly connected to the mixing tank and is located on the outside of the mixing tank, and the F-shaped rod is also arranged at one end of the bottom plate.

[0012] Wherein, the supporting member includes multiple vibration springs, an anti-deflection cover and multiple support rods. The multiple vibration springs are respectively arranged in the anti-deflection cover and welded between the extraction tank and the anti-deflection cover. The anti-deflection cover is fixedly connected to the bottom plate through the support rods, is located at the other end of the bottom plate, and is also arranged around the outside of the extraction tank.

[0013] A preparation device for chiral 3-hydroxyhexanoic acid of the present invention comprises a heating element, a mixing tank, a supporting element, an extraction tank, a lifting element and a bottom plate, wherein the heating element comprises a plurality of heating rods and a connecting ring, a first rotating shaft is arranged in the mixing tank, a plurality of first stirring rods are arranged on the outside of the first rotating shaft, a protective cover is arranged above the mixing tank, a mixing motor is arranged on the protective cover, and the mixing motor drives the first rotating shaft, a discharge pipe is arranged below the mixing tank, a filtering mechanism is arranged below the discharge pipe, and a collecting bucket is arranged on the bottom plate. By optimizing the device structure through the design, various parameters in the preparation process can be more accurately controlled, and the design can realize automated production, reduce manual intervention, thereby improving production efficiency, and further improving production efficiency and product quality, and can reduce scrap rate and rework rate, and then reduce production cost. In this way, the technical problem that the device structure used in the preparation process in the above structure is too simple, which makes it easy to have unstable product quality and low production efficiency in the preparation process is effectively solved. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art are briefly introduced below.

[0015] Figure 1 It is a three-dimensional stereogram of the first embodiment of the present invention.

[0016] Figure 2 is a side view of the first embodiment of the present invention.

[0017] Figure 3 The present invention Figure 2 Section view along line AA.

[0018] Figure 4 Schematic diagram of the structure of the heating element in the first embodiment of the present invention.

[0019] Figure 5 is a side view of a second embodiment of the present invention.

[0020] Figure 6 The present invention Figure 5 Sectional view along line BB.

[0021] Figure 7It is a schematic structural diagram of the second embodiment of the present invention when the driving gear and the driven gear are meshing.

[0022] Figure 8 is a side view of a third embodiment of the present invention.

[0023] Fig. 9 The present invention Figure 8 Sectional view along the CC line.

[0024] Fig.10 The present invention Fig. 9 A partial enlarged view of point D in the middle.

[0025] 101-mixing tank, 102-support, 103-extraction tank, 104-lifting member, 105-bottom plate, 106-heating rod, 107-connecting ring, 108-first rotating shaft, 109-first stirring rod, 110-protective cover, 111-mixing motor, 112-discharging pipe, 113-filtering mechanism, 114-collecting barrel, 115-feeding pipe, 116-temperature sensor, 117-observation glass, 118-timer, 119-receiving pipe, 120-liquid inlet pipe, 121-vibration motor, 122-discharge pipe, 201-driven gear, 202-second rotating shaft, 203-second stirring rod, 204-driving gear, 205-support rod, 206-F-shaped rod, 207-vibration spring, 208-anti-bias cover, 209-support rod, 301-first filter screen, 302-second filter screen, 303-filter tank, 304-sealing cover, 305-lead-out pipe, 306-first holding ring, 307-second holding ring, 308-electromagnetic control valve. DETAILED DESCRIPTION

[0026] Embodiments of the present invention are described in detail below. Examples of the embodiments are shown in the accompanying drawings. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, but should not be construed as limiting the present invention.

[0027] First embodiment:

[0028] See also Figure 1 to Figure 4 ,in Figure 1 is a three-dimensional stereogram of the first embodiment of the present invention, Figure 2 is a side view of a first embodiment of the present invention, Figure 3 The present invention Figure 2 The cross-sectional view along the AA line. Figure 4 Schematic diagram of the structure of the heating element in the first embodiment of the present invention.

[0029] The present invention provides a preparation device of chiral 3-hydroxyhexanoic acid, comprising a heating element, a mixing tank 101, a supporting element 102, an extraction tank 103, a lifting element 104 and a bottom plate 105, wherein the heating element comprises a plurality of heating rods 106 and a connecting ring 107, a first rotating shaft 108 is arranged in the mixing tank 101, a plurality of first stirring rods 109 are arranged outside the first rotating shaft 108, a protective cover 110 is arranged above the mixing tank 101, a mixing motor 111 is arranged on the protective cover 110, and the mixing motor 111 drives the first rotating shaft 108, a discharge pipe 112 is arranged below the mixing tank 101, a filtering mechanism 113 is arranged below the discharge pipe 112, a collecting barrel 114 is arranged on the bottom plate 105, a plurality of the heating rods 106 are respectively fixedly connected to the connecting ring 107 and are located below the connecting ring 107, and the connecting ring 107 is connected to the first rotating shaft 108 by bolts. The mixing tank 101 is fixedly connected and located on the mixing tank 101, and the plurality of heating rods 106 extend to the inner wall of the mixing tank 101. The mixing tank 101 is arranged at one end of the bottom plate 105 through the support member 102, and the extraction tank 103 is arranged at the other end of the bottom plate 105 through the lifting member 104, and the extraction tank 103 is also located directly below the filtering mechanism 113. By optimizing the device structure through the design, various parameters in the preparation process can be more accurately controlled, and the design can realize automated production and reduce manual intervention, thereby improving production efficiency, and then improving production efficiency and product quality, reducing scrap rate and rework rate, and then reducing production costs. In this way, the technical problem that the device structure used in the preparation process in the above structure is too simple, which makes it easy to have unstable product quality and low production efficiency during the preparation process, is effectively solved.

[0030] Among them, a feeding pipe 115 and a temperature sensor 116 are arranged above the mixing tank 101, and an observation glass 117 and a timer 118 are arranged on the outside of the mixing tank 101. The feeding pipe 115 is used to conveniently add raw materials into the mixing tank 101, and the temperature sensor 116 monitors the temperature inside the mixing tank 101 in real time to ensure that the reaction is carried out at an appropriate temperature.

[0031] Secondly, a material receiving pipe 119 and a liquid inlet pipe 120 are arranged above the extraction tank 103, a vibration motor 121 is arranged on the outside of the extraction tank 103, a discharge pipe 122 is arranged below the extraction tank 103, and the collecting bucket 114 is located directly below the discharge pipe 122. The material receiving pipe 119 and the liquid inlet pipe 120 can conveniently receive the material from the mixing tank 101 and add the extractant. The vibration motor 121 is used to improve the extraction efficiency and promote the mixing of the material and the extractant through vibration. The discharge pipe 122 can conveniently control the discharge of the material after extraction to ensure the flexibility of operation.

[0032] When using a chiral 3-hydroxyhexanoic acid preparation device of the present embodiment, propionyl acetate methylase, reductase, hydrogen donor, nicotinamide purine dinucleoside phosphate and phosphate buffer are added to the mixing tank 101, the mixing motor 111 is started, and the mixing motor 111 drives the first rotating shaft 108 and the first stirring rods 109 to stir and mix the raw materials, and then the raw materials are heated at a temperature of 20-50° for 10-30 hours by the heating rod 106, and then the enzyme and other residues in the raw materials are filtered out by the filtering mechanism 113 and discharged into the extraction tank 103, and ethyl acetate equal to the remaining raw materials is added for extraction, and the vibration motor 121 is started at the same time, and the vibration of the vibration motor 121 helps In order to accelerate the dissolution and diffusion process of ethyl acetate in the material, so that ethyl acetate can penetrate into the raw material faster and extract the required effective ingredients, the extraction tube in the present design is made of transparent glass, and the staff can observe the extraction situation at any time. After the extraction is completed, the obtained organic phase is discharged into the collection barrel 114, and then anhydrous sodium sulfate is added to remove water, and the organic solvent is removed by rotary evaporation to obtain chiral compound IV or IVV, and finally an inorganic base is added for hydrolysis reaction. Chiral 3-hydroxyhexanoic acid methyl ester is hydrolyzed to obtain chiral 3-hydroxyhexanoic acid. In this way, the technical problem that the device structure used in the preparation process in the above structure is too simple, which makes it easy to have unstable product quality and low production efficiency in the preparation process is effectively solved.

[0033] Second embodiment:

[0034] Based on the first embodiment, please refer to Figure 5 to Figure 7 ,in Figure 5 is a side view of a second embodiment of the present invention, Figure 6 The present invention Figure 5 The cross-sectional view of the BB line. Figure 7 2 is a schematic structural diagram of the second embodiment of the present invention when the driving gear 204 and the driven gear 201 are meshed.

[0035] The present invention provides a preparation device for chiral 3-hydroxyhexanoic acid, which also includes a plurality of auxiliary stirring components, wherein the auxiliary stirring components include a driven gear 201 and a second rotating shaft 202, a plurality of second stirring rods 203 are arranged on the outer side of the second rotating shaft 202, a driving gear 204 is arranged on the first rotating shaft 108, the driven gear 201 is fixedly connected to the second rotating shaft 202 and is located on the second rotating shaft 202, the second rotating shaft 202 is rotatably connected to the mixing tank 101 and is located in the mixing tank 101, the driving gear 204 is meshed with the driven gear 201, and the driving gear 204 is meshed with the driven gear 201. The gear 204 and the driven gear 201 are both located in the protective cover 110. The driving gear 204 is driven by the first rotating shaft 108 to rotate clockwise, and the driven gear 201 rotates counterclockwise under the action of the driving gear 204, so that the second rotating shaft 202 and the plurality of second stirring rods 203 stir the raw materials. Under the action of the clockwise rotation of the first stirring rod 109 and the counterclockwise rotation of the second stirring rod 203, the raw materials form a more complex flow pattern in the mixing tank 101, thereby increasing the contact opportunities between different components and promoting more uniform mixing.

[0036] Among them, the second rotating shaft 202 is arranged around the outer side of the first rotating shaft 108, and the second stirring rod 203 is located between the corresponding two first stirring rods 109. The structural setting of this design can prevent the first stirring rod 109 from contacting the second rotating shaft 202 and the second stirring rod 203 from contacting the first rotating shaft 108.

[0037] Secondly, the support member 102 includes a support rod 205 and an F-shaped rod 206, the support rod 205 is fixedly connected to the F-shaped rod 206 and is located on the F-shaped rod 206, and the support rod 205 is also arranged at one end of the bottom plate 105, the F-shaped rod 206 is fixedly connected to the mixing tank 101 and is located on the outside of the mixing tank 101, and the F-shaped rod 206 is also arranged at one end of the bottom plate 105. Through the combination of the F-shaped rod 206 and the support rod 205, a more stable support is provided for the mixing tank 101.

[0038] At the same time, the supporting member 104 includes a plurality of vibration springs 207, an anti-deflection cover 208 and a plurality of support rods 209. The plurality of vibration springs 207 are respectively arranged in the anti-deflection cover 208 and welded between the extraction tank 103 and the anti-deflection cover 208. The anti-deflection cover 208 is fixedly connected to the bottom plate 105 through the support rods 209 and is located at the other end of the bottom plate 105. It is also arranged around the outer side of the extraction tank 103. The vibration motor 121 and the vibration spring 207 work together in the extraction tank 103 to improve the extraction efficiency, accelerate dissolution and diffusion, prevent blockage and provide shock absorption and buffering, which helps to optimize the extraction process and improve product quality and production efficiency.

[0039] When using a preparation device for chiral 3-hydroxyhexanoic acid of the present embodiment, the driving gear 204 is driven by the first rotating shaft 108 to rotate clockwise, and the driven gear 201 rotates counterclockwise under the action of the driving gear 204, so that the second rotating shaft 202 and the plurality of second stirring rods 203 stir the raw materials. Under the action of the clockwise rotation of the first stirring rod 109 and the counterclockwise rotation of the second stirring rod 203, the raw materials form a more complex flow pattern in the mixing tank 101, thereby increasing the contact opportunities between different components and promoting more uniform mixing. The combination of the F-shaped rod 206 and the support rod 205 provides a more stable support for the mixing tank 101. The vibration motor 121 and the vibration spring 207 in the extraction tank 103 jointly play a role in improving extraction efficiency, accelerating dissolution and diffusion, preventing blockage and shock absorption, which helps to optimize the extraction process and improve product quality and production efficiency.

[0040] Third embodiment:

[0041] Based on the second embodiment, please refer to Figure 8 to Figure 10 ,in Figure 8 is a side view of a third embodiment of the present invention, Fig. 9 The present invention Figure 8 Cross-sectional view of the CC line, Fig.10 The present invention Fig. 9 A partial enlarged view of point D in the middle.

[0042] The present invention provides a preparation device for chiral 3-hydroxyhexanoic acid, wherein the filtering mechanism 113 comprises a first filter screen 301, a second filter screen 302 and a filter tank 303, a sealing cover 304 is threadedly provided on the top of the filter tank 303, a lead-out pipe 305 is provided on the bottom of the filter tank 303, a first supporting ring 306 and a second supporting ring 307 are provided in the filter tank 303, the first filter screen 301 is provided on the first supporting ring 306, the second filter screen 302 is provided on the second supporting ring 307, the sealing cover 304 is communicated with the discharge pipe 112 and is located below the discharge pipe 112, and the lead-out pipe 305 is located directly above the receiving pipe 119, and the first filter screen 301 and the second filter screen 302 of the present design can effectively filter out enzymes and other residues in the raw materials.

[0043] The second filter net 302 can pass through the first supporting ring 306, and the first supporting ring 306 is located above the second supporting ring 307. Through this design, the second filter net 302 can be taken out from the first supporting ring 306, so as to facilitate the cleaning of the filtered enzymes and other residues, and the first filter net 301 can be directly taken out.

[0044] Secondly, the discharge pipe 112, the lead-out pipe 305 and the discharge pipe are all provided with an electromagnetic control valve 308, and the setting of the electromagnetic control valve 308 can facilitate the discharge of raw materials.

[0045] When using a chiral 3-hydroxyhexanoic acid preparation device of this embodiment, the first filter screen 301 and the second filter screen 302 of this design can effectively filter out enzymes and other residues in the raw material. This design allows the second filter screen 302 to be removed from the first supporting ring 306, thereby facilitating the cleaning of the filtered enzymes and other residues, and the first filter screen 301 can be directly removed. The setting of the electromagnetic control valve 308 can facilitate the discharge of the raw material.

[0046] What is disclosed above is only one or more preferred embodiments of the present application, and cannot be used to limit the scope of rights of the present application. Ordinary technicians in this field can understand that all or part of the processes of implementing the above embodiments and equivalent changes made according to the claims of the present application are still within the scope covered by the present application.

Claims

1. A device for preparing chiral 3-hydroxyhexanoic acid, characterized in that: It includes a heating element, a mixing tank, a support element, an extraction tank, a lifting element and a bottom plate, wherein the heating element includes a plurality of heating rods and a connecting ring, a first rotating shaft is arranged in the mixing tank, a plurality of first stirring rods are arranged on the outside of the first rotating shaft, a protective cover is arranged above the mixing tank, a mixing motor is arranged on the protective cover, and the mixing motor drives the first rotating shaft, a discharge pipe is arranged below the mixing tank, a filtering mechanism is arranged below the discharge pipe, a collecting bucket is arranged on the bottom plate, a plurality of the heating rods are respectively fixedly connected to the connecting ring and are located below the connecting ring, the connecting ring is fixedly connected to the mixing tank by bolts and is located on the mixing tank, and a plurality of the heating rods extend to the inner wall of the mixing tank, the mixing tank is arranged at one end of the bottom plate through the support element, the extraction tank is arranged at the other end of the bottom plate through the lifting element, and the extraction tank is also located directly below the filtering mechanism.

2. The device for preparing chiral 3-hydroxyhexanoic acid according to claim 1, characterized in that: A feed pipe and a temperature sensor are arranged above the mixing tank, and an observation glass 117 and a timer are arranged outside the mixing tank.

3. The device for preparing chiral 3-hydroxyhexanoic acid according to claim 2, characterized in that: A material receiving pipe and a liquid inlet pipe are arranged above the extraction tank, a vibration motor is arranged outside the extraction tank, a discharge pipe is arranged below the extraction tank, and the collection bucket is located directly below the discharge pipe.

4. The device for preparing chiral 3-hydroxyhexanoic acid according to claim 3, characterized in that: The preparation device of chiral 3-hydroxyhexanoic acid also includes a plurality of auxiliary stirring components, the auxiliary stirring components include a driven gear and a second rotating shaft, a plurality of second stirring rods are arranged on the outer side of the second rotating shaft, a driving gear is arranged on the first rotating shaft, the driven gear is fixedly connected to the second rotating shaft and is located on the second rotating shaft, the second rotating shaft is rotatably connected to the mixing tank and is located in the mixing tank, the driving gear is meshed with the driven gear, and the driving gear and the driven gear are both located in the protective cover.

5. The device for preparing chiral 3-hydroxyhexanoic acid according to claim 4, characterized in that: The second rotating shaft is arranged around the outer side of the first rotating shaft, and the second stirring rod is located between two corresponding first stirring rods.

6. The device for preparing chiral 3-hydroxyhexanoic acid according to claim 5, characterized in that: The support member includes a support rod and an F-shaped rod, wherein the support rod is fixedly connected to the F-shaped rod and is located on the F-shaped rod, and the support rod is also arranged at one end of the bottom plate, the F-shaped rod is fixedly connected to the mixing tank and is located on the outside of the mixing tank, and the F-shaped rod is also arranged at one end of the bottom plate.

7. The device for preparing chiral 3-hydroxyhexanoic acid according to claim 6, characterized in that: The supporting member includes a plurality of vibration springs, an anti-deflection cover and a plurality of support rods. The plurality of vibration springs are respectively arranged in the anti-deflection cover and welded between the extraction tank and the anti-deflection cover. The anti-deflection cover is fixedly connected to the bottom plate through the support rods, is located at the other end of the bottom plate, and is also arranged around the outer side of the extraction tank.

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