Effervescent tablet for treating sphagitis and preparation method thereof

Abstract

The invention discloses a preparation method of an effervescent tablet for treating sphagitis, effective medicines of the effervescent tablet are only prepared from radix clematidis, fructus momordicae and solanum lyratum, the medicines are simple and reasonable in compatibility, a method of opening pungent taste and reducing bitter taste is taken as a principle, qi activity lesions of diseases are adjusted by utilizing nature and taste characteristics of the medicines, the pungent taste belongs to yang, the bitter taste belongs to yin, and the effect is obvious. Through combination and compatibility of pungent and warm medicines and bitter and cold medicines, the traditional Chinese medicine composition has the effects of promoting qi circulation, dispersing, excreting and descending turbid, so that normal operation of qi in a human body is ensured, and pharyngolaryngitis, especially chronic pharyngitis, is prevented and treated.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a method for preparing an effervescent tablet for treating pharyngitis. Background Art

[0002] Pharyngitis is a common and multiple disease, specifically divided into two categories: acute and chronic. Among them, chronic pharyngitis is a chronic inflammation of the pharyngeal mucosa, submucosal and lymphoid tissues, and is often a part of chronic inflammation of the upper respiratory tract. Since the throat drugs currently available on the market mostly treat and relieve acute and chronic pharyngitis with the function of clearing away heat and detoxifying, and the heat-clearing and detoxifying drugs are cold in nature, it is easy to cause ice to suppress evil and easily cause repeated attacks of pharyngitis. And most of the existing pharyngitis drugs are mainly oral, but most of the drugs are cold in nature, irritating the gastrointestinal tract, difficult for children to accept, and cannot be taken for a long time. Vomiting, nausea or adverse reactions will occur during the medication process, resulting in the drug being unable to play a normal role in the drug, and the actual application of the drug is limited. Some of the drugs are also lozenges, such as Huasu tablets, which have a large stimulation to the oral mucosal tissue, are not suitable for long-term consolidation, and some patients will have allergies. Summary of the invention

[0003] Therefore, based on the above background, the present invention provides a preparation method of an effervescent tablet for treating pharyngitis, wherein the effective drugs are only composed of Clematis chinensis, Momordica grosvenori and Sophora flavescens, the drugs are simple and the compatibility is reasonable, the method of "spicy to open and bitter to descend" is used as the basis of the prescription, and the nature and taste characteristics of the drugs are used to adjust the qi pathological changes of the disease, the pungent taste belongs to yang, and the bitter taste belongs to yin, through the combination of pungent and warm drugs and bitter and cold drugs, the compatibility plays the functions of dredging, dispersing and excreting, and lowering turbidity of qi, so as to ensure the normal operation of qi in the human body, so as to prevent and treat pharyngitis, especially to prevent and treat chronic pharyngitis.

[0004] The technical solution provided by the present invention is:

[0005] A Chinese medicine composition for treating pharyngitis, which is composed of the following raw materials in parts by weight:

[0006] 30-55 parts of Clematis chinensis, 25-45 parts of Momordica grosvenori, and 30-55 parts of Bletilla striata.

[0007] Preferably, it is composed of the following raw materials in parts by weight:

[0008] 55 parts of Clematis, 30 parts of Momordica, and 35 parts of Bletilla striata.

[0009] Preferably, it is composed of the following raw materials in parts by weight:

[0010] 50 parts of Clematis, 35 parts of Momordica grosvenori and 45 parts of Bletilla striata.

[0011] Based on the same inventive concept, the present invention also provides an effervescent tablet for treating pharyngitis, which is made from the above-mentioned traditional Chinese medicine composition.

[0012] Furthermore, the raw materials for its preparation include:

[0013] 30-45wt% of traditional Chinese medicine composition, 25-45wt% of sodium bicarbonate, 20-40wt% of anhydrous citric acid, 5-10wt% of mannitol, and 0.5-5wt% of polyethylene glycol.

[0014] Preferably, the raw materials for its preparation include:

[0015] 36wt% Chinese medicine composition, 30wt% sodium bicarbonate, 25wt% anhydrous citric acid, 7wt% mannitol, and 2wt% polyethylene glycol.

[0016] Further, the following steps are included:

[0017] 1) Take the raw materials according to the amount, grind the clematis, momordica grosvenori and smilax glabra respectively into ultrafine powder, sieve and mix them evenly;

[0018] 2) adding sodium bicarbonate, anhydrous citric acid, and anhydrous citric acid to the mixed powder of step 1) and mixing well to obtain a mixed powder;

[0019] 3) extruding the mixed powder obtained in step 2) into flakes, and then crushing them into particles;

[0020] 4) The particles obtained in step 3) are sieved (sieved particle size), polyethylene glycol is added to the sieved particles, mixed evenly, and then tableted again.

[0021] Furthermore, in step 1), 1000 mesh sieve is used for sieving.

[0022] The pharmacology of the Chinese medicine composition of the present invention is as follows:

[0023] Clematis: The rhizome is irregular and blocky, yellowish brown, with a woody stem base remaining at the top and many thin roots clustered on the bottom. The root is slender and cylindrical, about 8 to 16 cm long, about 1 to 4 mm in diameter, slightly curved, with a brown or brownish black surface and longitudinal stripes. It is brittle and easy to break, and the cortex and wood are easy to separate. The cross section is flat and round, the cortex is grayish yellow, and the wood is yellowish white. It tastes salty and is pungent and warm in nature. It has the effects of removing rheumatism, unblocking meridians, relieving arthralgia and eliminating bone choking. It is used for rheumatic arthralgia, bone choking and other diseases.

[0024] Solanum lyratum: A herbaceous vine of the Solanaceae family, with alternate leaves, most of which are lyre-shaped, cymes terminal or axillary, sparse flowers, flowering in summer and autumn, and fruiting in late autumn. It tastes sweet and cool in nature, has the effects of clearing heat and dampness, detoxifying and reducing swelling, and can treat laryngeal edema.

[0025] Momordica grosvenori: A climbing herb with perennial, hypertrophic, spindle-shaped or nearly spherical roots; it is cool in nature, sweet in taste, and enters the lung and large intestine meridians. It has the effects of clearing the lungs and resolving phlegm, moistening the intestines and promoting bowel movements, and relieving sore throat and opening the voice.

[0026] The above technical solution has the following beneficial effects:

[0027] The Chinese medicine composition of the present invention takes the method of "spicy opening and bitter descending" as the basis of the prescription, and uses the properties and taste characteristics of the medicine to adjust the qi pathological changes of the disease. The spiciness belongs to Yang, and the bitterness belongs to Yin. Through the combination of spiciness and warmness medicines and bitter and cold medicines, the compatibility plays the functions of dredging, dispersing and excreting, and descending turbidity of the qi mechanism, so as to ensure the normal operation of the qi in the human body, and to achieve the prevention and treatment of pharyngitis, especially the prevention and treatment of chronic pharyngitis. The present invention uses Clematidis as the main medicine, which can dispel wind and dampness, eliminate bone stagnation, and eliminate phlegm and cough with spiciness, and can restrict the coldness of the main and ministerial medicines with warmness, prevent the coldness from damaging the spleen and kidney too much, and avoid ice and contain evil spirits; uses Bletilla striata as the ministerial medicine, which can assist the main medicine in dissipating by clearing away heat and detoxicating, removing dampness and reducing swelling; uses Momordica grosvenori as the assistant medicine, which can clear away heat and moisten the lungs, and relieve throat and open the voice. The three medicines are used together, complement each other, hit the pathogenesis, and control pharyngitis with remarkable curative effect.

[0028] In the present invention, the ultrafinely pulverized and wall-broken medicinal powder is first subjected to dry granulation, and then tabletted to prepare an effervescent tablet form. Compared with the preparation of traditional effervescent tablets, the effervescent tablet has higher stability and is more conducive to storage. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Attached Figure 1 It is a preparation flow chart of the effervescent tablet of the present invention. DETAILED DESCRIPTION

[0030] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in combination with the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0031] Embodiment 1: An effervescent tablet for treating pharyngitis, the raw materials for its preparation include:

[0032] 36wt% Chinese medicine composition, 30wt% sodium bicarbonate, 25wt% anhydrous citric acid, 7wt% mannitol, and 2wt% polyethylene glycol.

[0033] The Chinese medicine composition is composed of the following raw materials in parts by weight:

[0034] 55 parts of Clematis, 30 parts of Momordica, and 35 parts of Bletilla striata.

[0035] Embodiment 2: An effervescent tablet for treating pharyngitis, the raw materials for its preparation include:

[0036] 36wt% Chinese medicine composition, 30wt% sodium bicarbonate, 25wt% anhydrous citric acid, 7wt% mannitol, and 2wt% polyethylene glycol.

[0037] The Chinese medicine composition is composed of the following raw materials in parts by weight:

[0038] 50 parts of Clematis, 35 parts of Momordica grosvenori and 45 parts of Bletilla striata.

[0039] The preparation of the effervescent tablets of Example 1 and Example 2 comprises the following steps:

[0040] 1) Take the raw materials according to the amount, grind the clematis root, momordica grosvenori and smilax glabra respectively, sieve through a 1000 mesh sieve and mix evenly;

[0041] 2) adding sodium bicarbonate, anhydrous citric acid, and anhydrous citric acid to the mixed powder of step 1) and mixing well to obtain a mixed powder;

[0042] 3) extruding the mixed powder obtained in step 2) into flakes, and then crushing them into particles;

[0043] 4) Screening the particles obtained in step 3), adding polyethylene glycol to the screened particles, mixing evenly, and tableting again.

[0044] Each piece of the effervescent tablet prepared above is 4-5 g.

[0045] Comparative Example 1: An effervescent tablet for treating pharyngitis, the raw materials for its preparation include:

[0046] 36wt% Chinese medicine composition, 30wt% sodium bicarbonate, 25wt% anhydrous citric acid, 7wt% mannitol, and 2wt% polyethylene glycol.

[0047] The Chinese medicine composition is composed of the following raw materials in parts by weight:

[0048] 50 parts of Clematis, 35 parts of Momordica, and 45 parts of Taraxacum.

[0049] In this comparative example, Taraxacum mongolicum was used to replace Solanum lycopersicum.

[0050] The preparation method is the same as that of Examples 1 and 2.

[0051] Comparative Example 2: An effervescent tablet for treating pharyngitis, the raw materials for its preparation include:

[0052] 36wt% Chinese medicine composition, 30wt% sodium bicarbonate, 25wt% anhydrous citric acid, 7wt% mannitol, and 2wt% polyethylene glycol.

[0053] The Chinese medicine composition is composed of the following raw materials in parts by weight:

[0054] 55 parts of Clematis, 30 parts of Momordica, and 35 parts of Bletilla striata.

[0055] The preparation method of this comparative example comprises the following steps:

[0056] 1) Take the raw materials according to the amount, grind the clematis root, momordica grosvenori and smilax glabra respectively, sieve through a 1000 mesh sieve and mix evenly;

[0057] 2) adding sodium bicarbonate, anhydrous citric acid, and anhydrous citric acid to the mixed powder of step 1) and mixing well to obtain a mixed powder;

[0058] 3) Adding polyethylene glycol to the mixed powder obtained in step 3), mixing evenly, and pressing into tablets.

[0059] Oral toxicity test of the effervescent tablets prepared in Example 1 and Example 2.

[0060] Thirty adult mice from Kunming that passed the quarantine were randomly divided into three groups, namely, a control group, an Example 1 group, and an Example 2 group, with 10 mice in each group. The control group was gavaged with normal saline every day, the Example 1 group was gavaged with the liquid after the effervescent reaction of the effervescent tablet of Example 1, and the Example 2 group was gavaged with the liquid after the effervescent reaction of the effervescent tablet of Example 2.

[0061] The medicinal solutions of Example 1 and Example 2 were obtained by adding one effervescent tablet to 200 ml of water for effervescent reaction.

[0062] After fasting for 15 hours before the experiment, mice in each group were gavaged with 50 mL / kg of the drug. Samples were given once on the day of the experiment. Within 0 to 12 hours after the sample was given, the animals in each group were carefully observed and recorded for toxic reactions, symptoms, occurrence time, and death. No abnormalities were observed in the mice. After that, the animals were observed for 14 consecutive days, and the death of the animals was recorded. No deaths were observed in the mice. After 14 days, two mice were randomly selected from each group for dissection. The position, size, color, adhesion, surface and cut surface texture of the organs were observed with the naked eye. No abnormal changes were observed in the organs.

[0063] Animal effect experiment verification:

[0064] 60 male adult Kunming mice were randomly divided into 4 groups, namely, control group, model group, embodiment group, and comparative group, 15 mice in each group, and the mice in the control group, model group, embodiment group, and comparative group were gavaged with drugs at 50 mL / kg, the control group and model group were gavaged with distilled water, the embodiment group was gavaged with the liquid after the effervescent reaction of the effervescent tablet of Example 2 (one effervescent tablet was added to 200 ml of water for effervescent reaction), and the comparative group was gavaged with the liquid after the effervescent reaction of the effervescent tablet of Comparative Example 1. On the 1st, 3rd, and 5th day after administration, 15% ammonia water was evenly applied to the pharynx of each group of rats (except the control group), once a day, and each time lasted for about 5 seconds. 24 hours after the last gavage, the animals were killed, and the pharyngeal tissue was fixed in 10% formalin for pathological observation, and scored according to the standards of Table 1.

[0065] Table 1: Scoring criteria for chronic pharyngitis

[0066]

[0067] References for the animal effect verification experiment: Tang Daxuan, Ge Lin, et al., Study on the effect of Ganju Bingmei tablets in preventing and treating pharyngitis, "Pharmacology and Clinical Medicine of Traditional Chinese Medicine", 2010; 26(5).

[0068] The results are shown in Table 2.

[0069] Group Control group Model Group Example Group Comparative group Physiological scores 0.15±0.00 2.8±0.95 0.7±0.99 1.9±0.84

[0070] Table 2: Results of mouse effect verification experiment

[0071] The physiological scores in Table 2 above are mucosal congestion score + mucous gland hyperplasia score + fibrous connective tissue hyperplasia score + lymphoid follicle increase score.

[0072] From Table 2 above, it is obvious that the effervescent tablet of Example 2 can effectively alleviate the pathological manifestations of pharyngitis, while the comparative example, in which Taraxacum officinale is replaced with Herba Sophorae Fructus, has a significantly reduced effect on relieving pharyngitis compared to the example group.

[0073] The present invention and its implementation methods are described above, and such description is not restrictive, and the actual methods are not limited thereto. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design implementation methods and embodiments similar to the technical solution without creativity, which should all fall within the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating pharyngitis, characterized in that: It is composed of the following raw materials in parts by weight: 30-55 parts of Clematis chinensis, 25-45 parts of Momordica grosvenori, and 30-55 parts of Bletilla striata.

2. A Chinese medicine composition for treating pharyngitis according to claim 1, characterized in that: It is composed of the following raw materials in parts by weight: 55 parts of Clematis, 30 parts of Momordica, and 35 parts of Bletilla striata.

3. A Chinese medicine composition for treating pharyngitis according to claim 1, characterized in that: It is composed of the following raw materials in parts by weight: 50 parts of Clematis, 35 parts of Momordica grosvenori and 45 parts of Bletilla striata.

4. An effervescent tablet for treating pharyngitis, characterized in that: It is prepared from the traditional Chinese medicine composition according to any one of claims 1 to 3.

5. An effervescent tablet for treating pharyngitis according to claim 4, characterized in that: The raw materials for its preparation include: 30-45wt% of traditional Chinese medicine composition, 25-45wt% of sodium bicarbonate, 20-40wt% of anhydrous citric acid, 5-10wt% of mannitol, and 0.5-5wt% of polyethylene glycol.

6. An effervescent tablet for treating pharyngitis according to claim 5, characterized in that: The raw materials for its preparation include: 36wt% Chinese medicine composition, 30wt% sodium bicarbonate, 25wt% anhydrous citric acid, 7wt% mannitol, and 2wt% polyethylene glycol.

7. A method for preparing an effervescent tablet for treating pharyngitis according to claim 5 or 6, characterized in that: The steps include: 1) Take the raw materials according to the amount, grind the clematis, momordica grosvenori and smilax glabra respectively into ultrafine powder, sieve and mix them evenly; 2) adding sodium bicarbonate, anhydrous citric acid, and anhydrous citric acid to the mixed powder of step 1) and mixing well to obtain a mixed powder; 3) extruding the mixed powder obtained in step 2) into flakes, and then crushing them into particles; 4) Screening the particles obtained in step 3), adding polyethylene glycol to the screened particles, mixing evenly, and tableting again.

8. A method for preparing an effervescent tablet for treating pharyngitis according to claim 7, characterized in that: In step 1), a 1000 mesh sieve is used for sieving.

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