Capsule skin composition containing Sanzan gum as well as preparation method and application of capsule skin composition

Abstract

The invention provides a capsule shell composition containing Sanzan gum as well as a preparation method and application of the capsule shell composition. According to the invention, carrageenan derived from algae, Sanzan gum derived from microorganisms, pullulan and trehalose are compounded, and necessary ions are supplemented, so that a compound composition is obtained. The composition is added into water according to a certain proportion, and through high-temperature swelling mixing, degassing, glue pouring and drying, the soft capsule skin containing Sanzan glue is prepared. Tests show that the prepared capsule shell is good in tensile strength, rapid in water dissolution and low in oil permeability, can achieve the performance similar to that of a gelatin capsule shell, has good technical feasibility, operation feasibility and production application feasibility, and provides a good choice for production of the capsule shell / shell.

Description

Technical Field

[0001] The invention belongs to the technical field of capsules, and in particular relates to a capsule skin composition containing trisammonium gum and a preparation method and application thereof. Background Art

[0002] Capsules are generally used to fill powders or granules that are irritating to the esophagus or gastric mucosa, or drugs that have a bad taste, are easy to volatilize, are easily decomposed by saliva in the mouth, and are easily inhaled into the trachea. They can protect the drug properties from being destroyed and protect the digestive organs and / or respiratory tract. Removing the capsule shell may cause drug loss and waste, and reduce the efficacy of the drug. In addition, some drugs need to be dissolved and absorbed in the intestine, and capsules protect the drugs from being destroyed by gastric acid. In medicine, capsules are often made of special film-forming materials (such as gelatin, cellulose, polysaccharides, etc.), and the contents (such as powdered, liquid drugs, etc.) or dosed are placed in them for easy swallowing.

[0003] In addition to gelatin capsules, plant capsules are also gaining more and more attention from the public because they do not contain animal-derived ingredients, have fewer uncertainties such as animal diseases or vegetarian concepts, and have relatively low safety risks. Even so, most of the raw materials for plant capsules, such as hydroxypropyl methylcellulose (HPMC) and modified starch, still require etherification or esterification of cotton pulp, wood pulp, starch, etc. from plants during the production process, and the use of chemical components for grafting is indispensable during the process. The post-processing process is prone to organic solvents or chemical component residues, which also poses certain risks.

[0004] With the development of various plant-based and microbial-based hydrophilic colloid or polysaccharide products, products derived from pure plant extraction or fermentation are increasingly recognized by the market and consumers because their production process is transparent, the raw materials are all derived from food, and the products do not require further chemical modification. This has laid a good foundation for the downstream applications of such products. Summary of the invention

[0005] The purpose of the present invention is to provide a capsule skin composition containing trisammonia gum and a preparation method and application thereof.

[0006] In order to achieve the purpose of the present invention, in a first aspect, the present invention provides a capsule skin composition containing tri-carrageenan, comprising the following components in parts by weight: 5 to 12 parts of food-grade pullulan, 0.3 to 1 parts of κ-carrageenan, 0.1 to 0.5 parts of tri-carrageenan, 3 to 5 parts of plasticizer and 0.2 to 0.8 parts of food-grade potassium ion compound, which are made up to 100 parts with water;

[0007] The composition is obtained by blending the above components with water, heating to swell, degassing, pouring glue and drying.

[0008] Furthermore, the composition also includes 0.05 to 0.1 parts of a preservative.

[0009] Furthermore, the water viscosity and potassium chloride viscosity of the Sanzan gel are 2000-3500cp, the viscosity of 0.25% synthetic brine is 1600-3500MPa·s, and the gel strength is 150-500g / cm 2 .

[0010] Furthermore, the plasticizer may be selected from at least one of trehalose, fructose, glucose, sorbitol, maltitol, isomalt and the like.

[0011] Furthermore, the potassium ion compound can be selected from at least one of soluble potassium salt compounds such as food-grade potassium chloride, potassium sulfate, potassium acetate, potassium propionate, potassium lactate, potassium citrate, potassium sorbate, potassium benzoate, potassium cinnamate, potassium phosphate, etc.

[0012] Furthermore, the preservative can be selected from at least one of potassium sorbate, sodium benzoate, sodium dehydroacetate, parahydroxybenzoate, calcium propionate, sodium diacetate, sodium lactate, nisin, natamycin and the like.

[0013] In a second aspect, the present invention provides a method for preparing the composition, comprising the following steps:

[0014] (1) Weigh food-grade pullulan, κ-carrageenan, trisammonium gum, plasticizer and food-grade potassium ion compound in parts by mass (5-12): (0.3-1): (0.1-0.5): (3-5): (0.2-0.8), and mix with deionized water to a total of about 100 parts by mass;

[0015] (2) adding 0.05-0.1 parts of preservative to the mixture of step (1), stirring at 200-500 rpm for 1 hour to allow the materials to be fully mixed and swollen;

[0016] (3) placing the mixture of step (2) in a 75±5°C water bath and heating it for 1 to 1.5 hours to allow molecular reconstruction to occur, during which time a small tabletop stirrer is used to continuously stir at a speed of 150 to 500 rpm to ensure uniform heating;

[0017] (4) Add deionized water to a total of 100 parts by weight, stir evenly, and quickly transfer to a water bath ultrasonic device at 65-70° C., and start ultrasonic degassing for 10-30 minutes;

[0018] (5) Perform necessary index measurements while hot, or pour into a flat plate groove with a depth of about 1 to 3 mm while hot, smooth it with a ruler or a flat plate and remove excess glue, and lay it flat to cool;

[0019] (6) The sample obtained in step (5) is placed in a constant temperature and humidity chamber at a temperature of 30-35°C and a relative humidity of 45-60% and dried for 5-15 hours. The capsule skin is carefully removed from the flat plate groove for further testing.

[0020] Furthermore, the ultrasonic condition is: ultrasonic frequency 45-100 KHz.

[0021] In a third aspect, the present invention provides use of the composition in preparing soft and hard capsule shells.

[0022] In a fourth aspect, the present invention provides the use of the composition as a food, health product or pharmaceutical capsule wall material.

[0023] The technical principle of the present invention is as follows: a certain proportion of kappa-carrageenan and water viscosity and potassium chloride solution viscosity are both greater than 2000cp (MPa·s), 0.25% synthetic salt water viscosity is greater than 1600MPa·s, and gel strength is greater than 150g / cm 2 The Sanzan gum product is then supplemented with potassium ions that can make carrageenan gel and plasticizer components that promote the formation of capsule skin and its release in water. After high-temperature swelling, the carrageenan and Sanzan gum molecules are reorganized, and cross-linking is completed in the presence of plasticizers. After degassing and removing bubbles, it is poured into a mold with a thickness of 1.0mm at 50-65℃. After natural cooling, it is placed in a constant temperature and humidity box at a temperature of 30-35℃ and a relative humidity of 45-60% to dry for 5-15h, and capsule skins with different moisture contents are obtained, which can be used in soft and hard capsule shells.

[0024] Although pullulan has film-forming properties, it cannot form a gel and requires long-term drying to obtain a film skin, which cannot meet actual production needs; the brittle gel formed by carrageenan at high temperature has extremely weak tensile strength, and the gel formed by low-concentration carrageenan at high temperature is insufficient in strength and very sticky; high-concentration carrageenan cannot be used well due to its excessive viscosity. The three can be compounded in a certain proportion to achieve a good synergistic effect, thereby improving the above indicators to a certain extent. Even so, the tensile strength of the product formed by the above-mentioned compound product is still insufficient, so it is supplemented with an appropriate proportion of plasticizer. Common plasticizers such as sugars or glycerol are often used as the first choice because they are rich in hydroxyl groups, but glycerol was found during use to seriously affect the gel temperature of the above-mentioned compound capsule skin material, resulting in slow gelation of the product and inability to use it smoothly. Therefore, choosing sugar as its plasticizer can not only improve the tensile strength of the capsule skin, but also ensure its good solubility in water.

[0025] By means of the above technical solution, the present invention has at least the following advantages and beneficial effects:

[0026] The present invention compounds carrageenan from algae with trisammonia gum, pullulan and trehalose from microorganisms, supplemented with necessary ions, to obtain a compound composition. The composition is added to water in a certain proportion, and a soft capsule skin containing trisammonia gum is prepared by high-temperature swelling and mixing, degassing, pouring and drying. According to tests, the capsule skin prepared by the present invention has good tensile strength, rapid water dissolution, low oil permeability, and can achieve performance similar to that of gelatin capsule skin, has good technical feasibility and operational feasibility, and has production and application feasibility, providing a good choice for the production of capsule skin / shell. DETAILED DESCRIPTION

[0027] The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention. Unless otherwise specified, the technical means used in the examples are conventional means well known to those skilled in the art, and the raw materials used are all commercially available products.

[0028] In order to verify the difference in product performance, the following method was used to evaluate product performance in the following examples:

[0029] 1. Determination of viscosity of capsule solution

[0030] Take the capsule solution before pouring, measure and record its viscosity at 70±1℃;

[0031] Measuring equipment: Brookfield LVDV-II+Pro viscometer, 64# rotor, 30rpm.

[0032] 2. Determination of gel temperature

[0033] Pour the prepared 75℃ solution into a 40mL beaker, use an iron stand and a butterfly clamp to fix the thermometer and keep its lower end in the center of the solution, let the solution gradually cool down at room temperature, quickly and slightly move the thermometer, and observe the gelation. When wrinkles appear on the surface of the compound glue and there is a small gap between the thermometer and the compound glue instead of being surrounded by liquid, it indicates that the solution has reached a gel state. Record the temperature of the thermometer at this time, which is the gelation temperature.

[0034] 3. Determination of capsule skin moisture

[0035] Take 2-3g of soft capsule skin, carefully and quickly cut it into pieces of about 2mm×5mm, evenly distribute it on the tray, and use a moisture analyzer to measure the moisture content of the capsule material. The parameters selected are: drying temperature 105℃; soft heating mode, slow heating time 3min. After 3min, maintain 105℃ and continue the measurement until the end. The system automatically calculates the moisture content of the capsule skin, records the readings, and obtains the moisture content of the capsule skin.

[0036] 4. Determination of water absorption rate of capsule skin

[0037] Cut the capsule skin into 6 small pieces of about 30mm×40mm in size, label them and weigh them accurately, place them in 500mL of distilled water at 20℃ to swell, take out the capsule skin after 1 hour, wipe off the surface liquid with filter paper, and weigh them accurately. Calculate the initial dry weight of the film based on the water content. Calculate the water absorption rate of the capsule skin using the following formula:

[0038]

[0039] Where: m1 represents the initial weight of the capsule skin;

[0040] m2 represents the tare weight of the water-absorbing bag obtained by weighing after 1 hour;

[0041] w represents the moisture content of the cyst skin, in %.

[0042] 5. Capsule skin tensile strength determination

[0043] The capsule skin was cut into thin strips with a width of 5 mm. The tensile strength and elastic modulus of the prepared capsule skin were tested using a TA-XT Plus physical property tester and an A / SPR probe. The test procedure was as follows: pre-test speed: 60 mm / min, test speed: 90 mm / min, post-test speed: 100 mm / min, test distance: 150 mm, trigger force 5 g. The tensile strength and elastic modulus data of the capsule skin were recorded. Each component was measured 5 times and the average value was taken.

[0044] 6. Determination of texture characteristics of capsule jelly

[0045] Pour the degassed capsule skin solution into a container with a diameter of 50 mm, cool to room temperature, and then place in a refrigerator at 8±1℃ for 14 hours. After taking it out, quickly use the TA-XT Plus physical property tester with a P0.5 probe to perform TPA test on the prepared capsule jelly. The test procedure is as follows: pre-test speed: 1.0 mm / min, test speed: 5.0 mm / min, post-test speed: 5.0 mm / min, downward pressure ratio 30%, trigger force 5g, and dwell time 5 seconds. Record the texture data of the capsule jelly, repeat the measurement 5 times for each component, and take the average value.

[0046] 7. Determination of rubber dissolution rate

[0047] Weigh 0.1g of lemon yellow pigment into a 100ml volumetric flask, add water to the scale to obtain a lemon yellow solution, take 0.5, 1.0, 2.0, 4.0, 6.0, 8.0, 10.0mL respectively, dilute and make up to 100mL, take the above solutions and measure the absorbance at a wavelength of 425nm, and then draw a standard curve based on the concentration-absorbance.

[0048] Prepare the dried film according to the previous method (add lemon yellow as an indicator), weigh it accurately, and place it in a beaker in a constant temperature water bath shaker. Use 500 ml of distilled water as the dissolution medium, the temperature is 37±0.5℃, the rotation speed is 100 rpm, sample once every 10 minutes, and take 5 ml of the dissolution solution each time (and add an equal volume of water in time), measure the absorbance (A) value of lemon yellow, and obtain the lemon yellow concentration at different time points. Fit the curve according to the formula to obtain the rubber dissolution rate k value.

[0049] mC t / SC ∞ The slope of the plot against t is the dissolution rate k, in units of mg·(min·cm 2 ) -1 , which means the rubber moves in cm per minute. 2 The mass number of mg pigment dissolved on the surface area is the dissolution rate of the rubber. Where M is the mass of the rubber, C t is the concentration of lemon yellow at time t, C ∞ is the maximum concentration of tartrazine, that is, the concentration of tartrazine after all the rubber is completely dissolved; S is the surface area of ​​the solid solute.

[0050] 8. Capsule skin oil permeability test

[0051] Add 5.0 g of vegetable oil into a 15 mL test tube, seal the mouth of the test tube tightly with the test capsule and invert it on the filter paper. Place it in a desiccator for 48 hours to prevent moisture in the air from affecting the experimental results, and measure the weight change of the filter paper.

[0052] P=△W / 5.0×100%

[0053] Where P is the oil permeability (%), and ΔW is the change in filter paper mass (g).

[0054] Example 1 A soft capsule shell formula containing Sanzan gum and its preparation method

[0055] This embodiment provides a soft capsule shell formula containing Sanzan gum and a preparation method thereof, comprising the following steps:

[0056] 1. Weigh commercially available food-grade pullulan: κ-carrageenan: trisammonia gum: trehalose: potassium chloride in a mass ratio of 12:1:0.3:3:0.2 to prepare a capsule skin composition.

[0057] 2. Add deionized water and the above composition in parts by mass to about 100 parts.

[0058] 3. Add 0.1 parts of potassium sorbate in step 2 and stir at 200-500 rpm for 1 hour to allow the materials to be fully mixed and swollen.

[0059] 4. Place the mixture from step 3 in a 75±1°C water bath and heat for 1 h to allow molecular reconstruction. During this time, use a small tabletop stirrer to continuously stir at 150 rpm to ensure uniform heating.

[0060] 5. Make up to 100 parts with deionized water and stir evenly. Quickly transfer to a water bath ultrasonic equipment at 65-70℃ and turn on ultrasonic degassing for 10 minutes.

[0061] 6. Carry out necessary index measurements while hot, or pour it into a flat plate groove with a depth of 1mm while hot, smooth it with a ruler or flat plate and clean off excess glue, and lay it flat to cool.

[0062] 7. Place the sample in a constant temperature and humidity chamber at 30-35°C and 45-60% relative humidity and dry it for 15 hours before taking it out.

[0063] 8. Carefully remove the capsule skin from the plate slot for further testing.

[0064] During the preparation of the above samples, 0.05% of lemon yellow pigment was added as a colorant. The Sanzan gum used was measured according to the Sanzan gum index detection method in the National Health Commission's Announcement No. 4 of 2020. Its 1% aqueous solution viscosity is 2129MPa·s, the 1% potassium chloride solution containing 1% Sanzan gum has a viscosity of 2249MPa·s, the 0.25% synthetic saline has a viscosity of 1809MPa·s, and the gel strength is 165g / cm 2 The Sanzan gel sample was purchased from Meihua Biotechnology Group Co., Ltd., model number MHF-80.

[0065] Example 2 A soft capsule shell formula containing Sanzan gum and its preparation method

[0066] Commercially available food-grade pullulan: κ-carrageenan: tribasic gum: trehalose: potassium chloride were weighed in the mass proportion of 5:1:0.3:3:0.2 to prepare a capsule skin composition.

[0067] The remaining steps are the same as those in Example 1, and the Sanzan glue sample is the same as that in Example 1.

[0068] Example 3 A soft capsule shell formula containing Sanzan gum and its preparation method

[0069] Commercially available food-grade pullulan: κ-carrageenan: trisammonia gum: trehalose: potassium chloride were weighed in the mass proportion of 12:0.3:0.3:3:0.05 to prepare a capsule skin composition.

[0070] The remaining steps are the same as those in Example 1, and the Sanzan glue sample is the same as that in Example 1.

[0071] Example 4 A soft capsule shell formula containing Sanzan gum and its preparation method

[0072] Commercially available food-grade pullulan: κ-carrageenan: trisammonia gum: trehalose: potassium chloride were weighed in the mass proportion of 12:1:0.1:3:0.2 to prepare a capsule skin composition.

[0073] The remaining steps are the same as those in Example 1, and the Sanzan glue sample is the same as that in Example 1.

[0074] Example 5 A soft capsule shell formula containing Sanzan gum and its preparation method

[0075] Commercially available food-grade pullulan: κ-carrageenan: trisammonia gum: trehalose: potassium chloride were weighed in the mass proportion of 12:1:0.1:5:0.2 to prepare a capsule skin composition.

[0076] The remaining steps are the same as those in Example 1, and the Sanzan glue sample is the same as that in Example 1.

[0077] Example 6 A soft capsule shell formula containing Sanzan gum and its preparation method

[0078] Commercially available food-grade pullulan: κ-carrageenan: trisammonia gum: crystalline fructose: potassium chloride were weighed in the mass proportion of 12:1:0.1:5:0.2 to prepare a capsule skin composition.

[0079] The remaining steps are the same as those in Example 1, and the Sanzan glue sample is the same as that in Example 1.

[0080] Example 7 A soft capsule shell formula containing Sanzan gum and its preparation method

[0081] Commercially available food-grade pullulan: κ-carrageenan: trisammonia gum: crystalline fructose: potassium citrate were weighed in the mass proportion of 12:1:0.1:5:0.3 to prepare a capsule skin composition.

[0082] The remaining steps are the same as those in Example 1, and the Sanzan glue sample is the same as that in Example 1.

[0083] Example 8 A soft capsule shell formula containing Sanzan gum and its preparation method

[0084] Commercially available food-grade pullulan: κ-carrageenan: trisammonia gum: crystalline fructose: potassium chloride were weighed in the mass proportion of 12:1:0.1:5:0.1 to prepare a capsule skin composition.

[0085] The remaining steps are the same as those in Example 1, and the Sanzan glue sample is the same as that in Example 1.

[0086] Comparative Example 1: A soft capsule shell formula containing gelatin and its preparation method

[0087] The preparation method is as follows:

[0088] 1. Commercially available food-grade bovine bone gelatin (freezing strength 190 Bloom g, Blaine viscosity 3.95 MPa·s): glycerol: potassium sorbate: deionized water were weighed in a ratio of 20:9:0.1:80 to prepare a capsule skin composition.

[0089] 2. Let the above materials stand for 1 hour to allow them to fully swell.

[0090] 3. Place the mixture from step 2 in a 75±1°C water bath and heat for 1 h to allow molecular reconstruction. During this time, use a small tabletop stirrer to continuously stir at 150 rpm to ensure uniform heating.

[0091] 4. Make up to 100 parts with deionized water and stir evenly. Quickly transfer to a water bath ultrasonic equipment at 65-70°C and turn on ultrasonic degassing for 10 minutes.

[0092] 5. Carry out necessary index measurements while hot, or pour it into a flat plate groove with a depth of 1mm while hot, smooth it with a ruler or flat plate and clean off excess glue, and lay it flat to cool.

[0093] 6. Place the sample in a constant temperature and humidity chamber at 30-35°C and 45-60% relative humidity and dry it for 15 hours before taking it out.

[0094] 7. Carefully remove the capsule skin from the plate slot for further testing.

[0095] 0.05 g of lemon yellow was added as a colorant during the sample preparation.

[0096] Comparative Example 2: A soft capsule shell formula and preparation method thereof

[0097] Commercially available food-grade pullulan: κ-carrageenan: trisammonia gum: trehalose: potassium chloride were weighed in the mass proportion of 13:1:0.3:3:0.2 to prepare a capsule skin composition.

[0098] The remaining steps are the same as those in Example 1, and the Sanzan glue sample is the same as that in Example 1.

[0099] Comparative Example 3: A soft capsule shell formula and preparation method thereof

[0100] Commercially available food-grade pullulan: κ-carrageenan: trisammonia gum: trehalose: potassium chloride were weighed in the mass proportion of 12:1.2:0.3:3:0.2 to prepare a capsule skin composition.

[0101] The remaining steps are the same as those in Example 1, and the Sanzan glue sample is the same as that in Example 1.

[0102] Comparative Example 4: A soft capsule shell formula and preparation method thereof

[0103] Commercially available food-grade pullulan: κ-carrageenan: trisammonia gum: trehalose: potassium chloride were weighed in the mass proportion of 12:1:0.35:3:0.2 to prepare a capsule skin composition.

[0104] The remaining steps are the same as those in Example 1, and the Sanzan glue sample is the same as that in Example 1.

[0105] Comparative Example 5: A soft capsule shell formula and preparation method thereof

[0106] Commercially available food-grade pullulan: κ-carrageenan: trisammonia gum: trehalose: potassium chloride were weighed in the mass proportion of 12:1:0.1:6:0.2 to prepare a capsule skin composition.

[0107] The remaining steps are the same as those in Example 1, and the Sanzan glue sample is the same as that in Example 1.

[0108] Comparative Example 6: A soft capsule shell formula and preparation method thereof

[0109] The capsule skin composition was prepared according to the formulation of Example 1, except that pullulan was not added and was replaced by water.

[0110] The remaining steps are the same as those in Example 1, and the Sanzan glue sample is the same as that in Example 1.

[0111] Comparative Example 7: A soft capsule shell formula and preparation method thereof

[0112] The capsule skin composition was prepared according to the formulation of Example 1, except that carrageenan was not added and was replaced by water.

[0113] The remaining steps are the same as those in Example 1, and the Sanzan glue sample is the same as that in Example 1.

[0114] Comparative Example 8: A soft capsule shell formula and preparation method thereof

[0115] The capsule skin composition was prepared according to the formulation of Example 1, except that trehalose was not added and was replaced by water.

[0116] The remaining steps are the same as those in Example 1, and the Sanzan glue sample is the same as that in Example 1.

[0117] Comparative Example 9: A soft capsule shell formula and preparation method thereof

[0118] A capsule skin composition was prepared according to the formulation of Example 1, except that trisammonium chloride was not added and was replaced by water.

[0119] The remaining steps are the same as in Example 1.

[0120] Comparative Example 10: A soft capsule shell formula and preparation method thereof

[0121] The capsule skin composition was prepared according to the formula of Example 1, except that the common commercial product of Sanzan was used. The viscosity of its 1% aqueous solution was 1029 MPa·s, the viscosity of 1% KCl solution containing 1% Sanzan was 1679 MPa·s, the viscosity of 0.25% synthetic saline was 689 MPa·s, and the gel strength was 32 g / cm 2 .

[0122] The remaining steps are the same as in Example 1.

[0123] The test results of the above embodiments and comparative examples are shown in Table 1 and Table 2:

[0124] Table 1 Capsule skin test results

[0125]

[0126] Table 2 Test results of texture characteristics of capsule jelly

[0127]

[0128]

[0129] It can be seen from the above experimental data that the composite composition provided by the present invention, after sample preparation and testing, has a higher viscosity of the capsule skin solution than the gelatin capsule skin, which is related to the compounding of the three-zan gum, carrageenan and pullulan used (such as each embodiment compared with comparative example 1). In terms of gel temperature, each embodiment is higher than the gelatin capsule skin to varying degrees. A high gel temperature is more favorable for the capsule skin and the capsule prepared therefrom, which can help to extend its shelf life, especially for the summer with high temperatures, and a higher gel temperature contributes to the stability of the product. However, too high a gel temperature is not conducive to production operations, and will greatly increase the production sol and operating temperature, thereby affecting production efficiency. It can be seen from the above data that an inappropriate ratio may cause an increase in gel temperature, such as comparative examples 3-6 and 8-9. On the one hand, it may be due to the relatively high gel temperature of carrageenan and three-zan gum, and the influence of an excessively high ratio on the gel temperature, and on the other hand, it may be related to the insufficient ratio of certain components. In comparative example 7, in which carrageenan is not added, the gel strength is significantly reduced, which may be related to the fact that when three-zan gum is used independently, the ratio does not reach its optimal gel concentration.

[0130] In addition, from the comparison between Comparative Example 5 and Example 5, it can be seen that although the proportion of plasticizer increases, it has little effect on the overall indicators of the capsule skin, indicating that the proportion of plasticizer does not need to be further increased. Considering the comprehensive cost, it is believed that the proportion of the present invention is relatively reasonable.

[0131] It can be seen from the water absorption rate of the capsule skin in Comparative Examples 8-10 that if no plasticizer and Sanzan gum are added, or the Sanzan gum index does not meet the required requirements, the water absorption rate of the capsule skin may be reduced. This may be related to the high proportion of hydroxyl groups in the plasticizer, which is easier to absorb water, or the insufficient performance of Sanzan gum with low indexes. From the tensile strength and elastic modulus results of Comparative Examples 6-10, the removal of several components separately also has a significant effect on the tensile properties of the prepared capsule skin, which shows that there is a synergistic effect between the components, and the combination together can play a better role in improving the gel properties. The same results are also shown in Comparative Examples 8-10. Plasticizers and Sanzan gum affect the water absorption rate of the capsule skin, and thus affect its dissolution rate, and there is a corresponding relationship between them.

[0132] At the same time, the experiment also found that when no carrageenan or pullulan was added, the texture characteristics of the capsule skin, such as brittleness and elasticity, also changed significantly. This is related to the fact that carrageenan can only form brittle gels, while pullulan cannot form gels by itself, and carrageenan can only form viscoelastic gels by itself. Only when several substances are compounded and coordinated in certain specific proportions can their effects be best exerted.

[0133] The soft capsule skin formula provided by the present invention provides a new idea for the future production of soft capsule shells. At the same time, the obtained product does not contain animal ingredients or chemical ingredients, is very attractive to vegetarians and animal protectionists, and will not be interfered by animal disease factors, and has good industrial application potential.

[0134] Although the present invention has been described in detail above with general descriptions and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements can be made based on the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention all fall within the scope of protection claimed by the present invention.

Claims

1. A capsule skin composition containing Sanzan gum, characterized in that: The invention comprises the following components in parts by weight: 5-12 parts of food-grade pullulan, 0.3-1 parts of kappa-carrageenan, 0.1-0.5 parts of tris-an gum, 3-5 parts of plasticizer and 0.2-0.8 parts of food-grade potassium ion compound, which are made up to 100 parts with water; The composition is obtained by blending the above components with water, heating to swell, degassing, pouring glue and drying.

2. The composition according to claim 1, characterized in that The composition further comprises 0.05 to 0.1 parts of preservatives.

3. The composition according to claim 1, characterized in that The water viscosity and potassium chloride viscosity of the Sanzan gel are 2000-3500cp, the viscosity of 0.25% synthetic brine is 1600-3500MPa·s, and the gel strength is 150-500g / cm 2 .

4. The composition according to claim 1, characterized in that The plasticizer is selected from at least one of trehalose, fructose, glucose, sorbitol, maltitol and isomalt.

5. The composition according to claim 1, characterized in that The potassium ion compound is selected from at least one of food-grade potassium chloride, potassium sulfate, potassium acetate, potassium propionate, potassium lactate, potassium citrate, potassium sorbate, potassium benzoate, potassium cinnamate, and potassium phosphate.

6. The composition according to claim 2, characterized in that The preservative is selected from at least one of potassium sorbate, sodium benzoate, sodium dehydroacetate, parahydroxybenzoate, calcium propionate, sodium diacetate, sodium lactate, nisin, and natamycin.

7. A method for preparing the composition according to any one of claims 2 to 6, characterized in that: The following steps are involved: (1) Weigh food-grade pullulan, kappa-carrageenan, trisammonia gum, plasticizer and food-grade potassium ion compound in parts by mass (5-12): (0.3-1): (0.1-0.5): (3-5): (0.2-0.8), and mix with deionized water to a total of 100 parts by mass; (2) adding 0.05-0.1 parts of preservative to the mixture of step (1), stirring at 200-500 rpm for 1 hour to allow the materials to be fully mixed and swollen; (3) placing the mixture of step (2) in a water bath at 75±5°C and heating for 1 to 1.5 hours, stirring continuously at a speed of 150 to 500 rpm; (4) Add deionized water to a total of 100 parts by weight, stir evenly, and quickly transfer to a water bath ultrasonic device at 65-70° C., and start ultrasonic degassing for 10-30 minutes; (5) Pour into a flat plate groove with a depth of 1 to 3 mm while still hot, smooth it with a ruler or a flat plate and remove excess glue, then lay it flat to cool; (6) The sample obtained in step (5) is placed in a constant temperature and humidity chamber at a temperature of 30-35° C. and a relative humidity of 45-60% and dried for 5-15 hours.

8. Use of the composition according to any one of claims 1 to 7 in preparing capsule shells.

9. Use of the composition according to any one of claims 1 to 7 as a food, health product or pharmaceutical capsule wall material.

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