Rosemary nerve-calming bacteriostatic spray and production method thereof
By using antibacterial sprays with plant extracts such as rosemary and nano-silver components, the existing antibacterial sprays have been solved, and the significant antibacterial effect and long-term calming and sleep aiding effects are achieved, and the production process is simplified.
Patent Information
- Application Number
- CN202411845858.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-16
- Publication Date
- 2025-03-21
AI Technical Summary
The existing antibacterial sprays have poor antibacterial stability, single functions, and complex production processes, making them difficult to be produced in industrial use.
Natural plant extracts such as rosemary extract, scutellaria baicalensis extract, Magnolia officinalis extract, Acacia flower extract, Jupiter extract, chitosan quaternary ammonium salt, nanosilver and sodium citrate are used, and antibacterial sprays are prepared through a simple production process, combined with deionized water as a solvent.
It has achieved significant antibacterial effects, which are effective against a variety of bacteria. The antibacterial effects are basically unchanged after storage, with good stability, and have long-term calming and sleep-assisting effects. The production process is simple and easy to industrially produce.
Smart Images
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Abstract
Description
Technical Field
[0001] The invention belongs to the technical field of antibacterial sprays, and in particular relates to a rosemary tranquilizing antibacterial spray and a production method thereof. Background Art
[0002] Antibacterial spray is a new type of antibacterial agent, which adopts the biological principle of "using bacteria to control bacteria, beneficial bacteria to inhibit bacteria", and is a substance that can inhibit bacterial growth. Although the existing antibacterial spray has a certain antibacterial effect, the antibacterial stability is not strong, and the antibacterial effect will be greatly reduced after storage. It has a single function and does not have a calming effect. Its production process is relatively complicated and is not easy to industrialize. Therefore, how to overcome the above-mentioned technical problems and defects has become a key problem that needs to be solved. Summary of the invention
[0003] The purpose of the present invention is to overcome the shortcomings of the prior art and to provide a rosemary tranquilizing and antibacterial spray and a production method thereof. The antibacterial spray not only has a significant antibacterial effect, but also has a long-lasting tranquilizing and sleep-inducing effect. The antibacterial effect remains substantially unchanged after storage, and the stability is good. The production process is simple and easy to industrialize.
[0004] The object of the present invention is achieved in this way: a rosemary tranquilizing and antibacterial spray comprises the following components in percentage by mass: 10-15% of rosemary extract, 5-8% of scutellaria extract, 3-5% of magnolia bark extract, 4-6% of julibrissin flower extract, 3-5% of gallnut extract, 2-4% of chitosan quaternary ammonium salt, 1-3% of nano silver, 0.5-1.5% of sodium citrate, and the balance is deionized water.
[0005] Preferably, the rosemary calming and antibacterial spray comprises the following components in mass percentage: 11-13% rosemary extract, 6-8% scutellaria extract, 3-4% magnolia bark extract, 5-6% julibrissin flower extract, 3-4% gallnut extract, 2-3% chitosan quaternary ammonium salt, 1-2% nano silver, 0.8-1.2% sodium citrate, and the balance is deionized water; more preferably, the rosemary calming and antibacterial spray comprises the following components in mass percentage: 12% rosemary extract, 7% scutellaria extract, 4% magnolia bark extract, 5% julibrissin flower extract, 4% gallnut extract, 3% chitosan quaternary ammonium salt, 2% nano silver, 1% sodium citrate, and the balance is deionized water.
[0006] The present invention also discloses a production method of the rosemary tranquilizing and antibacterial spray, which comprises the following steps:
[0007] (1) adding a formula amount of rosemary extract, scutellaria baicalensis extract, magnolia bark extract, chitosan quaternary ammonium salt, and nanosilver into deionized water, stirring at a temperature of 50 to 60° C. and a speed of 500 r / min for 20 to 30 minutes to completely dissolve and mix them, thereby obtaining a first mixed solution;
[0008] (2) adding the formulated amount of Albizzia Julibrissin flower extract and Galla chinensis extract to the first mixed solution, stirring at 50 to 60° C. and 500 r / min for 10 to 15 min to completely dissolve and mix them, thereby obtaining a second mixed solution;
[0009] (3) adding a formulated amount of sodium citrate to the second mixed solution, stirring at a temperature of 30 to 40° C. and a speed of 350 r / min for 5 to 10 min, cooling naturally to room temperature, and filtering to obtain a rosemary tranquilizing and antibacterial spray.
[0010] Wherein, the preparation method of the rosemary extract is as follows:
[0011] (1) Wash rosemary leaves with distilled water, dry them, and grind them into particles;
[0012] (2) extracting for 1 to 2 hours at a material-liquid mass ratio of 1:8 to 12 and an extraction temperature of 50 to 60° C., extracting the filtered residue for 0.5 to 1.5 hours at a material-liquid mass ratio of 1:6 to 8 and an extraction temperature of 50 to 60° C., filtering, combining the two filtrates, concentrating, drying, and pulverizing to obtain a rosemary extract; wherein the extracting solution used for the two extractions is 75% ethanol solution.
[0013] The preparation method of the scutellaria baicalensis extract is as follows:
[0014] (1) Wash the scutellaria baicalensis root with distilled water, dry it in the air, and grind it into particles;
[0015] (2) Soak the crushed Scutellaria baicalensis in 12-15 times the amount of distilled water at 95-100° C. for 1-2 hours, decoct for 2-3 hours, filter, and then decoct the residue in 8-10 times the amount of distilled water for 1.5-2.5 hours, filter, combine the two filtrates, concentrate, dry, and pulverize to obtain the Scutellaria baicalensis extract.
[0016] The preparation method of the Magnolia officinalis extract is as follows:
[0017] (1) Wash the bark of Magnolia officinalis with distilled water, dry it in the air, and grind it into particles;
[0018] (2) extracting for 1 to 2 hours at a material-liquid mass ratio of 1:15 to 20 and an extraction temperature of 70 to 80° C., extracting the filtered residue for 0.5 to 1.5 hours at a material-liquid mass ratio of 1:10 to 15 and an extraction temperature of 70 to 80° C., filtering, combining the two filtrates, concentrating, drying, and pulverizing to obtain a Magnolia officinalis extract; wherein the extracting liquids used in both extractions are propane.
[0019] The preparation method of the Albizia Julibrissin flower extract is as follows:
[0020] (1) washing the flowers of Albizzia julibrissin with distilled water, drying them, and crushing them into particles;
[0021] (2) extracting for 1 to 2 hours at a material-liquid mass ratio of 1:10 to 12 and an extraction temperature of 50 to 65° C., extracting the filtered residue for 0.5 to 1.0 hour at a material-liquid mass ratio of 1:8 to 10 and an extraction temperature of 50 to 65° C., filtering, combining the two filtrates, concentrating, drying, and pulverizing to obtain an Albizia Julibrissin flower extract; wherein the extracting solution used for the two extractions is 95% ethanol solution.
[0022] The preparation method of the Chinese gallnut extract is as follows:
[0023] (1) Wash the Chinese gallnut with distilled water, dry it, and grind it into particles;
[0024] (2) Soak the crushed Chinese gallnut in 10-12 times the amount of distilled water at 95-100° C. for 1-2 hours, decoct for 2-3 hours, filter, and then decoct the residue in 6-8 times the amount of distilled water for 1.0-1.5 hours, filter, combine the two filtrates, concentrate, dry, and crush to obtain a Chinese gallnut extract.
[0025] Compared with the prior art, the present invention has the following beneficial effects:
[0026] 1. The rosemary tranquilizing and antibacterial spray of the present invention comprises rosemary extract, scutellaria baicalensis extract, magnolia bark extract, chitosan quaternary ammonium salt and nano silver as antibacterial ingredients, flos albizziae extract and chinensis chinensis extract as tranquilizing ingredients, sodium citrate as a stabilizer, and deionized water as a solvent. The antibacterial ingredients and tranquilizing ingredients used are all natural plant extracts, and the spray is low in cost and is green, environmentally friendly and safe.
[0027] 2. The rosemary tranquilizing and antibacterial spray of the present invention has a simple production process and is easy to industrialize. It has been verified through experiments that the product has significant antibacterial effects on Escherichia coli, Staphylococcus aureus, Candida albicans, and Pseudomonas aeruginosa. The antibacterial effect remains basically unchanged after storage, and the product has good stability. The product also has a long-lasting tranquilizing and sleep-inducing effect. DETAILED DESCRIPTION
[0028] The present invention is described in more detail below through specific implementation modes.
[0029] Example 1
[0030] A method for producing a rosemary tranquilizing and antibacterial spray comprises the following steps:
[0031] (1) adding 10.0 g of rosemary extract, 8.0 g of scutellaria baicalensis extract, 3.0 g of magnolia bark extract, 2.0 g of chitosan quaternary ammonium salt, and 3.0 g of nanosilver to 65.5 g of deionized water, stirring at 50° C. and 500 r / min for 30 min to completely dissolve and mix the mixture, thereby obtaining a first mixed solution;
[0032] (2) adding 5.0 g of Albizzia julibrissin flower extract and 3.0 g of Galla chinensis extract to the first mixed solution, stirring at 50° C. and 500 r / min for 15 min to completely dissolve and mix the mixture, thereby obtaining a second mixed solution;
[0033] (3) Add 0.5 g of sodium citrate to the second mixed solution, stir at 30° C. and 350 r / min for 10 min, cool naturally to room temperature, and filter to obtain a rosemary tranquilizing and antibacterial spray.
[0034] Example 2
[0035] A method for producing a rosemary tranquilizing and antibacterial spray comprises the following steps:
[0036] (1) adding 11.0 g of rosemary extract, 6.0 g of scutellaria baicalensis extract, 4.0 g of magnolia bark extract, 4.0 g of chitosan quaternary ammonium salt, and 1.0 g of nanosilver to 64.2 g of deionized water, stirring at 500 r / min for 28 min at a temperature of 53° C. to completely dissolve and mix the mixture, thereby obtaining a first mixed solution;
[0037] (2) adding 6.0 g of Albizzia julibrissin flower extract and 3.0 g of Galla chinensis extract to the first mixed solution, stirring at 500 r / min for 13 min at 53° C. to completely dissolve and mix the mixture, thereby obtaining a second mixed solution;
[0038] (3) 0.8 g of sodium citrate was added to the second mixed solution, stirred at 35° C. and 350 r / min for 8 min, cooled naturally to room temperature and filtered to obtain a rosemary tranquilizing and antibacterial spray.
[0039] Example 3
[0040] A method for producing a rosemary tranquilizing and antibacterial spray comprises the following steps:
[0041] (1) adding 12.0 g of rosemary extract, 7.0 g of scutellaria baicalensis extract, 4.0 g of magnolia bark extract, 3.0 g of chitosan quaternary ammonium salt, and 2.0 g of nanosilver to 62.0 g of deionized water, stirring at 500 r / min for 25 min at a temperature of 55° C. to completely dissolve and mix the mixture, thereby obtaining a first mixed solution;
[0042] (2) adding 5.0 g of Albizzia julibrissin flower extract and 4.0 g of Galla chinensis extract to the first mixed solution, stirring at 500 r / min for 12 min at 55° C. to completely dissolve and mix the mixture, thereby obtaining a second mixed solution;
[0043] (3) 1.0 g of sodium citrate was added to the second mixed solution, stirred at 35° C. and 350 r / min for 8 min, cooled naturally to room temperature, and then filtered to obtain a rosemary tranquilizing and antibacterial spray.
[0044] Example 4
[0045] A method for producing a rosemary tranquilizing and antibacterial spray comprises the following steps:
[0046] (1) adding 13.0 g of rosemary extract, 5.0 g of scutellaria baicalensis extract, 5.0 g of magnolia bark extract, 2.0 g of chitosan quaternary ammonium salt, and 2.0 g of nanosilver to 61.8 g of deionized water, stirring at 500 r / min for 22 min at 58° C. to completely dissolve and mix the mixture, thereby obtaining a first mixed solution;
[0047] (2) adding 6.0 g of Albizzia julibrissin flower extract and 4.0 g of Galla chinensis extract to the first mixed solution, stirring at 500 r / min for 10 min at 58° C. to completely dissolve and mix the mixture, thereby obtaining a second mixed solution;
[0048] (3) 1.2 g of sodium citrate was added to the second mixed solution, stirred at 40° C. and 350 r / min for 5 min, cooled naturally to room temperature and filtered to obtain a rosemary tranquilizing and antibacterial spray.
[0049] Example 5
[0050] A method for producing a rosemary tranquilizing and antibacterial spray comprises the following steps:
[0051] (1) adding 15.0 g of rosemary extract, 8.0 g of scutellaria baicalensis extract, 3.0 g of magnolia bark extract, 3.0 g of chitosan quaternary ammonium salt, and 1.0 g of nanosilver to 59.5 g of deionized water, stirring at 60° C. and 500 r / min for 20 min to completely dissolve and mix the mixture, thereby obtaining a first mixed solution;
[0052] (2) adding 4.0 g of Albizzia julibrissin flower extract and 5.0 g of Galla chinensis extract to the first mixed solution, stirring at 60° C. and 500 r / min for 10 min to completely dissolve and mix the mixture, thereby obtaining a second mixed solution;
[0053] (3) 1.5 g of sodium citrate was added to the second mixed solution, stirred at 40° C. and 350 r / min for 5 min, cooled naturally to room temperature and filtered to obtain a rosemary tranquilizing and antibacterial spray.
[0054] Test example
[0055] Test Example 1 Product Antibacterial Rate Test
[0056] The suspension quantitative test method was adopted to test the antibacterial rates of the antibacterial spray products of Examples 1 to 5 against Escherichia coli, Staphylococcus aureus, Candida albicans and Pseudomonas aeruginosa with reference to the suspension method in GB15979-2002.
[0057] Among them, the antibacterial spray products of Examples 1 to 5 at concentrations of 5.2 mg / ml, 10.4 mg / ml, 20.8 mg / ml, 41.6 mg / ml, and 83.2 mg / ml after 10 minutes of action are shown in Table 1:
[0058] Table 1
[0059]
[0060]
[0061] It can be seen from the test data in Table 1 that the antibacterial spray products of Examples 1 to 5 can achieve an antibacterial rate of 99.65-100% against Escherichia coli at concentrations of 5.2 mg / ml, 10.4 mg / ml, 20.8 mg / ml, 41.6 mg / ml, and 83.2 mg / ml after 10 minutes of action, an antibacterial rate of 99.41-100% against Staphylococcus aureus, an antibacterial rate of 99.07-100% against Candida albicans, and an antibacterial rate of 99.13-100% against Pseudomonas aeruginosa, that is, the antibacterial spray products of Examples 1 to 5 of the present invention have significant antibacterial effects on Escherichia coli, Staphylococcus aureus, Candida albicans, and Pseudomonas aeruginosa.
[0062] Test Example 2 Product Stability Test
[0063] The antibacterial spray products of Examples 1 to 5 were sealed and placed in a constant temperature incubator at 54° C. for 14 days (marked as Comparative Examples 1 to 5). The suspension quantitative test method was used to test the antibacterial spray products of Examples 1 to 5 and Comparative Examples 1 to 5, and the antibacterial rates against Escherichia coli, Staphylococcus aureus, Candida albicans, and Pseudomonas aeruginosa, respectively, with reference to the suspension method in GB15979-2002.
[0064] Among them, the antibacterial rate results of the antibacterial spray products of Examples 1 to 5 and Comparative Examples 1 to 5 after acting for 2 minutes, 5 minutes, 10 minutes, 15 minutes, and 20 minutes at a concentration of 20.8 mg / ml are shown in Table 2:
[0065] Table 2
[0066]
[0067]
[0068]
[0069] It can be seen from the test data in Table 2 that the antibacterial spray products of Comparative Examples 1 to 5 and the corresponding antibacterial spray products of Examples 1 to 5 have the same action time for the antibacterial rate of Escherichia coli, Staphylococcus aureus, Candida albicans and Pseudomonas aeruginosa to reach 100%; under the same action time, the antibacterial rate of the antibacterial spray products of Comparative Examples 1 to 5 and the corresponding antibacterial spray products of Examples 1 to 5 on Candida albicans is consistent, and the antibacterial rate on Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa is only slightly reduced; it shows that the antibacterial spray products of Examples 1 to 5 of the present invention are stable.
[0070] Test Example 3: Product calming effect test
[0071] Test subjects: 60 volunteers with poor sleep quality were selected and divided into 6 groups, with 10 people in each group. The 6 groups of volunteers used the antibacterial spray products of Examples 1 to 5 respectively.
[0072] How to use: Spray the same dose of the product on the bedside every day before going to bed. After using it for 15 and 30 days, rate the product.
[0073] Scoring criteria: 8 to 10 points indicate significant calming and sleep-inducing effects, 5 to 7 points indicate moderate calming and sleep-inducing effects, and 0 to 4 points indicate no obvious calming and sleep-inducing effects.
[0074] The test results are shown in Table 3:
[0075] Table 3
[0076] 15-day rating 30-day rating Example 1 9.5 9.8 Example 2 9.6 9.9 Example 3 9.9 10.0 Example 4 9.8 10.0 Example 5 9.7 9.9
[0077] It can be seen from the test data in Table 3 that the antibacterial spray products of Examples 1 to 5 of the present invention have the effects of calming the nerves and helping sleep, and the score after 30 days of use is higher than the score after 15 days of use, that is, the antibacterial spray products of Examples 1 to 5 have a long-lasting effect of calming the nerves and helping sleep.
[0078] In summary, from the results of Test Examples 1 to 3, it can be seen that the antibacterial spray products of Examples 1 to 5 of the present invention not only have good antibacterial effects, but also have good stability. The antibacterial effects remain basically unchanged after storage. In addition, they also have long-lasting calming and sleep-inducing effects.
[0079] The above embodiments are merely explanations of the present invention and are not limitations of the present invention. For those skilled in the art, any obvious modifications made thereto without departing from the principles and spirit of the present invention should be considered to be included in the scope of protection of the claims of the present invention.
Claims
1. A rosemary calming and antibacterial spray, characterized in that: The invention comprises the following components in percentage by mass: 10-15% of rosemary extract, 5-8% of scutellaria baicalensis extract, 3-5% of magnolia bark extract, 4-6% of julibrissin flower extract, 3-5% of gallnut extract, 2-4% of chitosan quaternary ammonium salt, 1-3% of nano silver, 0.5-1.5% of sodium citrate, and the balance is deionized water.
2. Rosemary tranquilizing and antibacterial spray as claimed in claim 1, characterized in that, The invention comprises the following components in percentage by mass: 11-13% of rosemary extract, 6-8% of scutellaria baicalensis extract, 3-4% of magnolia bark extract, 5-6% of julibrissin flower extract, 3-4% of gallnut extract, 2-3% of chitosan quaternary ammonium salt, 1-2% of nano silver, 0.8-1.2% of sodium citrate, and the balance is deionized water.
3. Rosemary tranquilizing and antibacterial spray as claimed in claim 1, characterized in that, The invention comprises the following components in percentage by mass: 12% of rosemary extract, 7% of scutellaria baicalensis extract, 4% of magnolia bark extract, 5% of julibrissin flower extract, 4% of gallnut extract, 3% of chitosan quaternary ammonium salt, 2% of nano silver, 1% of sodium citrate, and the balance is deionized water.
4. A method for producing the rosemary tranquilizing and antibacterial spray according to any one of claims 1 to 3, characterized in that: The following steps are involved: (1) adding a formula amount of rosemary extract, scutellaria baicalensis extract, magnolia bark extract, chitosan quaternary ammonium salt, and nanosilver into deionized water, stirring at a temperature of 50 to 60° C. and a speed of 500 r / min for 20 to 30 minutes to completely dissolve and mix them, thereby obtaining a first mixed solution; (2) adding the formulated amount of Albizzia Julibrissin flower extract and Galla chinensis extract to the first mixed solution, stirring at 50 to 60° C. and 500 r / min for 10 to 15 min to completely dissolve and mix them, thereby obtaining a second mixed solution; (3) adding a formulated amount of sodium citrate to the second mixed solution, stirring at a temperature of 30 to 40° C. and a speed of 350 r / min for 5 to 10 min, cooling naturally to room temperature, and filtering to obtain a rosemary tranquilizing and antibacterial spray.
5. The production method of rosemary tranquilizing and antibacterial spray as claimed in claim 4, characterized in that, The preparation method of the rosemary extract is as follows: (1) Wash rosemary leaves with distilled water, dry them, and grind them into particles; (2) extracting for 1 to 2 hours at a material-liquid mass ratio of 1:8 to 12 and an extraction temperature of 50 to 60° C., extracting the filtered residue for 0.5 to 1.5 hours at a material-liquid mass ratio of 1:6 to 8 and an extraction temperature of 50 to 60° C., filtering, combining the two filtrates, concentrating, drying, and pulverizing to obtain a rosemary extract; wherein the extracting solution used for the two extractions is 75% ethanol solution.
6. The production method of rosemary tranquilizing and antibacterial spray as claimed in claim 4, characterized in that, The preparation method of the scutellaria baicalensis extract is as follows: (1) Wash the scutellaria baicalensis root with distilled water, dry it in the air, and grind it into particles; (2) Soak the crushed Scutellaria baicalensis in 12-15 times the amount of distilled water at 95-100° C. for 1-2 hours, decoct for 2-3 hours, filter, and then decoct the residue in 8-10 times the amount of distilled water for 1.5-2.5 hours, filter, combine the two filtrates, concentrate, dry, and pulverize to obtain the Scutellaria baicalensis extract.
7. The production method of rosemary tranquilizing and antibacterial spray as claimed in claim 4, characterized in that, The preparation method of the Magnolia Bark Extract is as follows: (1) Wash the bark of Magnolia officinalis with distilled water, dry it in the air, and grind it into particles; (2) extracting for 1 to 2 hours at a material-liquid mass ratio of 1:15 to 20 and an extraction temperature of 70 to 80° C., extracting the filtered residue for 0.5 to 1.5 hours at a material-liquid mass ratio of 1:10 to 15 and an extraction temperature of 70 to 80° C., filtering, combining the two filtrates, concentrating, drying, and pulverizing to obtain a Magnolia officinalis extract; wherein the extracting liquids used in both extractions are propane.
8. The production method of rosemary tranquilizing and antibacterial spray as claimed in claim 4, characterized in that, The preparation method of the Albizia Julibrissin flower extract is as follows: (1) washing the flowers of Albizzia julibrissin with distilled water, drying them, and crushing them into particles; (2) extracting for 1 to 2 hours at a material-liquid mass ratio of 1:10 to 12 and an extraction temperature of 50 to 65° C., extracting the filtered residue for 0.5 to 1.0 hour at a material-liquid mass ratio of 1:8 to 10 and an extraction temperature of 50 to 65° C., filtering, combining the two filtrates, concentrating, drying, and pulverizing to obtain an Albizia Julibrissin flower extract; wherein the extracting solution used for the two extractions is 95% ethanol solution.
9. The production method of rosemary tranquilizing and antibacterial spray as claimed in claim 4, characterized in that, The preparation method of the Chinese gallnut extract is as follows: (1) Wash the Chinese gallnut with distilled water, dry it, and grind it into particles; (2) Soak the crushed Chinese gallnut in 10-12 times the amount of distilled water at 95-100° C. for 1-2 hours, decoct for 2-3 hours, filter, and then decoct the residue in 6-8 times the amount of distilled water for 1.0-1.5 hours, filter, combine the two filtrates, concentrate, dry, and crush to obtain a Chinese gallnut extract.