Novel method and equipment for filling nitrogen gas to protect liquid medicine

Abstract

The invention discloses a novel method and equipment for filling and filling nitrogen to protect liquid medicine, and relates to the technical field of filling equipment in pharmaceutical machinery, and the filling and nitrogen filling process is as follows: A, feeding bottles and plugs; b, inflating and plugging; c, station transfer; d, taking the plug and filling; e, pressing the plug again; f, bottle discharging; the novel nitrogen filling and filling device comprises a rack 15, a bottle feeding mechanism 1, a nitrogen filling station 7, a transfer station 9, a filling station 12 and a finished bottle discharging mechanism 16, wherein the bottle feeding mechanism 1, the nitrogen filling station 7, the transfer station 9, the filling station 12 and the finished bottle discharging mechanism 16 are sequentially arranged at the upper part of the rack 15 from right to left. The nitrogen filling machine has the characteristics of simple process, simple equipment structure, low use cost, relatively small occupied area of equipment, capability of greatly improving the quality of filled medicines and the like, and can be used for nitrogen filling of high-added-value products such as glucose, antibiotics, amino acid, fat emulsion, oral liquid, nutrient solution, biological agents and the like.

Description

Technical Field

[0001] The invention relates to the technical field of filling equipment in pharmaceutical machinery, in particular to a novel method and equipment for filling and protecting a liquid medicine with nitrogen. Background Art

[0002] As people's living standards continue to improve, customers have higher and higher requirements for nitrogen-filled products, and therefore higher requirements for residual oxygen and dissolved oxygen in the final product. In order to extend the shelf life of high value-added products such as glucose, antibiotics, amino acids, fat emulsions, oral liquids, nutrient solutions and biological preparations, nitrogen is filled into the gaps in the bottle to isolate the contact between air and liquid medicine as much as possible, thereby avoiding chemical reactions between oxygen in the air and some active molecules in the liquid medicine, which may lead to deterioration of the liquid medicine or changes in its composition.

[0003] The existing nitrogen filling methods are mainly the following:

[0004] One is to directly use a nitrogen tube to point at the bottle mouth and fill the bottle with nitrogen. The final residual oxygen content is ≤ about 3%, and there is no requirement for dissolved oxygen.

[0005] In this method, since nitrogen is filled after filling, the liquid medicine will be fully in contact with the air in the bottle during the process of being filled into the bottle, resulting in a very high dissolved oxygen concentration. Therefore, it is suitable for filling and nitrogen filling of products that do not require high residual oxygen content in the final product.

[0006] The second is to fill the empty bottle with nitrogen, then fill it, fill it with nitrogen at the same time, then evacuate it, fill it with nitrogen, evacuate it again, and fill it with nitrogen again. The number of repetitions is adjusted according to the effect, and finally the bottle is sealed with a stopper.

[0007] This method is suitable for filling and nitrogenating products with high requirements for residual oxygen content in the final product and high requirements for dissolved oxygen, and products with residual oxygen content ≤ 1%. It is also the mainstream production process for nitrogen-filled products.

[0008] Moreover, this method is to form a sealed cavity with multiple moving parts and the container containing the liquid medicine during the entire nitrogen filling process, and then evacuate the sealed cavity multiple times, and then fill it with nitrogen to replace the air in the bottle, and finally replace the air in the entire sealed cavity with nitrogen, so as to isolate the contact between oxygen and liquid medicine. This filling and nitrogen filling process has the following main disadvantages:

[0009] First, the equipment has a complex structure, high precision requirements, great difficulty in manufacturing, complex program control, and high requirements for operators;

[0010] Secondly, the vacuum control of the two vacuum systems of vacuum pumping and vacuum plug suction is very complicated, and plugs are easily lost, resulting in a low pass rate of plugging.

[0011] Third, when vacuuming, it is easy to draw the steam generated by the drug solution into the vacuum pipe, which will remain in the vacuum pipe after condensation, resulting in excessive particles in the pipe. When nitrogen is filled, the particles in the pipe may be blown back into the bottle, thus affecting the quality of the drug.

[0012] Fourthly, the liquid medicine in the bottle tends to shake during transportation, thus increasing the concentration of dissolved oxygen.

[0013] The third is to fill the empty bottle with nitrogen, then fill it, and then fill it with nitrogen after filling.

[0014] In this way, if the same workstation is used, first filling with nitrogen and then filling, the time of the entire filling operation will be prolonged, resulting in a decrease in production capacity per unit time; if two workstations are used, air will intrude during the process of transferring the workstations, which will lead to an increase in the amount of dissolved oxygen in the medicine solution.

[0015] Fourth, the empty bottles are filled with nitrogen, followed by filling and filling with nitrogen at the same time.

[0016] In this way, if it is at the same workstation, first fill with nitrogen and then fill with nitrogen at the same time, it will also extend the time of the whole action, resulting in a decrease in production capacity per unit time; if it is at two workstations, similarly, during the process of transferring the workstation, the intrusion of air will also cause an increase in the dissolved oxygen content in the liquid medicine.

[0017] The "nitrogen filling system for a desktop machine" disclosed in a Chinese patent (patent application number 202222936646.3) can protect the liquid medicine by nitrogen filling during the filling and plugging process, and has a simple structure and is easy to use. It includes a desktop machine body, on which a filling component and a plugging component are arranged in sequence along the production line direction, the filling component includes a needle rack with a filling needle, the needle rack is provided with a nitrogen filling needle used in conjunction with the filling needle, the plugging component is provided with a nitrogen inflator, and a nitrogen curtain injector is provided on the desktop machine body located between the filling component and the plugging component.

[0018] Another Chinese patent (patent application number is 202223346530.0) discloses a "nitrogen filling device for bottles before and after filling", which includes: a vent pipe, a vent seat, a gas distributor, a nitrogen filling nozzle and a bottle support plate. The vent seat and the gas distributor are respectively arranged around the vent pipe, and the vent seat and the gas distributor are arranged up and down. The vent seat is provided with a gas seat nitrogen channel, and the gas distributor is provided with a gas plate nitrogen channel. The gas seat nitrogen channel connects the nitrogen outlet of the vent pipe and one end of the gas plate nitrogen channel. The other end of the gas plate nitrogen channel is connected to the nitrogen filling nozzle. The outlet of the nitrogen filling nozzle is arranged opposite to the bottle support plate, and there is an adjustable bottle height space between the outlet of the nitrogen filling nozzle and the bottle support plate. Compared with the prior art, the utility model has a simple structure, low cost, and is very convenient to install, adjust, use and maintain. The performance is stable and reliable, and the filling efficiency is not affected. The utility model can be used to perform multiple nitrogen filling protections in the bottle before and after the liquid medicine is filled, which can prevent the medicine from being excessively oxidized due to long-term contact with air and affecting the quality of the medicine.

[0019] There is also a Chinese patent (patent application number 201510607536.4) disclosed "a vacuum nitrogen filling plugging device and production line", which includes a sleeve shaft, which includes a coaxial and relatively slidable outer shaft and inner shaft; the outer shaft is connected to the first lifting device, and the lower end of the outer shaft is provided with a sealing joint for sealing with the bottle body; the inner shaft is connected to the second lifting device, an airway is opened on the inner shaft, and a suction plug seat connected to the airway is provided at the lower end; a sealing component is provided between the inner and outer shafts, and a vacuum nitrogen filling interface is provided on the side wall of the outer shaft between the sealing component and the sealing joint; it can be seen that the above-mentioned vacuum nitrogen filling plugging device can form a small enclosed space at the bottle mouth, and the residual oxygen content can be accurately controlled by repeatedly performing vacuum and nitrogen filling work, and the plugging operation is immediately performed in the enclosed space after the nitrogen filling is completed, avoiding the re-introduction of oxygen into the bottle during the transportation process, reducing the defective rate, reducing the production cost, and improving the production efficiency. The invention also discloses a vacuum nitrogen filling plugging production line. Summary of the invention

[0020] In view of the shortcomings of the prior art, the technical problem to be solved by the present invention is to provide a method and equipment for filling and nitrogen filling, which has simple process, simple equipment structure, low use cost, relatively small equipment footprint, and can significantly improve the quality of filled medicines.

[0021] The technical solution adopted by the present invention is to invent a new method for filling nitrogen-filled protective liquid medicine, and the filling and nitrogen-filling process is as follows:

[0022] A. Bottle delivery and plug delivery: First, the bottle feeding mechanism delivers the clean liquid medicine bottle to the nitrogen filling station, and at the same time, the plug feeding and plug pressing mechanism delivers the bottle plug to the top of the liquid medicine bottle for standby use;

[0023] B. Nitrogen filling and plugging: Afterwards, insert the nitrogen filling mechanism into the medicine bottle and fill it with nitrogen. After the nitrogen in the medicine bottle is full and the nitrogen filling mechanism is pulled out of the bottle mouth, the plugging and plugging mechanism quickly presses the bottle plug down into the bottle mouth for standby use;

[0024] C. Station transfer: Afterwards, the bottle transfer mechanism transfers the nitrogen-filled and stoppered medicine bottles from the nitrogen filling station to the filling station for standby use;

[0025] D. Remove the plug and fill: Afterwards, the plug-removing and plug-pressing mechanism removes the plug of the medicine bottle filled with nitrogen and places it on the top of the medicine bottle. Then, the filling and nitrogen-filling mechanism inserts its filling and nitrogen-filling tube into the medicine bottle and fills the medicine bottle with the medicine. Nitrogen is also filled into the bottle during the filling process. When the filling and nitrogen-filling process is completed, the filling and nitrogen-filling tube is pulled out of the bottle mouth and put into standby use.

[0026] E. Re-corking: After the filling nitrogen tube is pulled out of the bottle mouth, the cork-taking and corking mechanism will quickly press the original bottle cork placed on the top of the liquid medicine bottle back into the bottle mouth for use;

[0027] F. Bottle discharging: Afterwards, the re-corked medicine liquid bottle is sent by the bottle discharging mechanism to the finished product bottle discharging mechanism, and then sent out by the finished product bottle discharging mechanism.

[0028] A pre-nitrogen filling station is also provided between the bottle feeding mechanism and the nitrogen filling station. When the bottle feeding mechanism delivers the clean medicine liquid bottle to the pre-nitrogen filling station, the pre-nitrogen filling mechanism is inserted into the medicine liquid bottle for pre-nitrogen filling. Thereafter, the bottle feeding mechanism continues to deliver the pre-nitrogen filled medicine liquid bottle to the nitrogen filling station.

[0029] The bottle moving mechanism in the nitrogen filling station is a linear conveying mechanism.

[0030] At the same time, a new filling and nitrogen charging device is also invented: it includes a frame 16, a bottle feeding mechanism 1, a nitrogen charging station 10, a filling station 14 and a finished bottle discharge mechanism 16, wherein the bottle feeding mechanism 1, the nitrogen charging station 7, the filling station 12 and the finished bottle discharge mechanism 17 are arranged in sequence on the upper part of the frame 16 from right to left.

[0031] The nitrogen filling station 10 includes a plug-in and plug-pressing mechanism 7, a nitrogen filling mechanism 5 and a bottle moving mechanism 6; the left and right ends of the bottle moving mechanism 6 are respectively connected to the right end of the filling station 14 and the left end of the bottle-in and plug-pressing mechanism 1, the plug-in and plug-pressing mechanism 7 and the nitrogen filling mechanism 5 are arranged on the upper part of the bottle moving mechanism 6, and the lower part of the plug-in and plug-pressing mechanism 7 is provided with a plug-in and plug-pressing head 8.

[0032] The filling station 14 includes a plug removing and plugging mechanism 11, a filling and nitrogen filling mechanism 12 and a bottle discharging mechanism 15; the left and right ends of the bottle discharging mechanism 15 are respectively connected to the right end of the finished bottle discharging mechanism 17 and the left end of the bottle moving mechanism 6 of the nitrogen filling station 10, the plug removing and plugging mechanism 11 and the filling and nitrogen filling mechanism 12 are arranged on the upper part of the bottle discharging mechanism 15, and the lower part of the plug removing and plugging mechanism 11 is provided with a plug removing and plugging head 13.

[0033] A pre-nitrogen filling station 4 is provided between the bottle feeding mechanism 1 and the nitrogen filling station 10 . The pre-nitrogen filling station 4 further includes a pre-nitrogen filling mechanism 3 . The pre-nitrogen filling mechanism 3 is provided on the upper part of the bottle feeding mechanism 1 .

[0034] The bottle moving mechanism 6 is a linear conveying mechanism.

[0035] The bottle discharging mechanism 15 is a linear conveying mechanism.

[0036] The bottle feeding mechanism 1 and the finished bottle discharging mechanism 17 are both linear conveying mechanisms.

[0037] Compared with the existing similar technologies and equipment, the novel method and equipment for filling nitrogen-filled protective liquid medicine of the present invention have the following technical advantages:

[0038] First, it adopts a linear conveying method with a simple structure and easy maintenance; it can easily achieve the action requirements of each workstation;

[0039] Second, the process is simple, the vacuuming action is eliminated, the mechanical action is optimized, the mechanical footprint is reduced, the air conditioning purification area is saved, and the use cost is reduced;

[0040] Third, there is no vacuuming action, which avoids the steam generated by the drug solution being drawn into the vacuum pipe during vacuuming, and remaining in the pipe after condensation, which leads to excessive particles in the pipe. When nitrogen is filled, the particles in the pipe may be blown back into the bottle, thus affecting the quality of the medicine.

[0041] Fourth, it integrates filling, nitrogen filling and plugging. It adopts jacketed tube filling, and nitrogen filling protection during filling, so that the liquid medicine is always isolated from the air. The plugging is performed immediately after filling, which not only reduces the time the liquid medicine is exposed to the air, but also reduces the handover between the dials, thus effectively improving the qualified rate and quality of the medicine.

[0042] Fifth, compared with the existing rotary conveying structure, it is easy to cause eddy currents in the laminar wind, thereby affecting the effect of the laminar wind, and thus the present invention using a linear conveying structure can better reflect the protective effect of the laminar wind. BRIEF DESCRIPTION OF THE DRAWINGS

[0043] Figure 1 It is a structural schematic diagram of the present invention.

[0044] In the figure: 1 is the bottle feeding mechanism, 2 is the medicine bottle, 3 is the pre-nitrogen filling mechanism, 4 is the pre-nitrogen filling station, 5 is the nitrogen filling mechanism, 6 is the bottle moving mechanism, 7 is the plug feeding and plugging mechanism, 8 is the plug feeding and plugging head, 9 is the bottle plug, 10 is the nitrogen filling station, 11 is the plug removing and plugging mechanism, 12 is the filling and nitrogen filling mechanism, 13 is the plug removing and plugging head, 14 is the filling station, 15 is the bottle discharging mechanism, 16 is the rack, and 17 is the finished bottle discharging mechanism. DETAILED DESCRIPTION

[0045] The present invention is further described below in conjunction with the accompanying drawings and embodiments. The following description is in the form of examples, but the protection scope of the present invention should not be limited thereto.

[0046] The directions in this specification and the drawings are as follows:

[0047] Figure 1 The front is the actual front, the inside is the actual back; the top is the actual top, the bottom is the actual bottom; the left and right are the actual left and right sides respectively.

[0048] Embodiment 1:

[0049] The novel filling and nitrogen charging device of the present embodiment is composed of a frame 16, a bottle feeding mechanism 1, a nitrogen charging station 10, a filling station 14 and a finished bottle discharging mechanism 17. The bottle feeding mechanism 1, the nitrogen charging station 10, the filling station 14 and the finished bottle discharging mechanism 17 are sequentially arranged on the upper part of the frame 16 from right to left, wherein the bottle feeding mechanism 1 and the finished bottle discharging mechanism 17 are suspended at the right end and the left end of the upper part of the frame 16 respectively.

[0050] The nitrogen filling station 10 is composed of a plug-in and plug-pressing mechanism 7, a nitrogen filling mechanism 5 and a bottle moving mechanism 6. The left and right ends of the bottle moving mechanism 6 are respectively connected to the right end of the filling station 14 and the left end of the bottle-in and plug-pressing mechanism 1. The plug-in and plug-pressing mechanism 7 and the nitrogen filling mechanism 5 are both arranged at the upper part of the bottle moving mechanism 6, and the nitrogen filling mechanism 5 is arranged at the lower part of the plug-in and plug-pressing mechanism 7. A plug-in and plug-pressing head 8 is also arranged at the lower part of the plug-in and plug-pressing mechanism 7.

[0051] The filling station 14 is composed of a plug removing and plugging mechanism 11, a filling and nitrogen filling mechanism 12 and a bottle discharging mechanism 15; the left and right ends of the bottle discharging mechanism 15 are respectively connected to the right end of the finished bottle discharging mechanism 17 and the left end of the bottle moving mechanism 6 of the nitrogen filling station 10, the plug removing and plugging mechanism 11 and the filling and nitrogen filling mechanism 12 are both arranged on the upper part of the bottle discharging mechanism 15, and the filling and nitrogen filling mechanism 12 is arranged on the lower part of the plug removing and plugging mechanism 11, and a plug removing and plugging head 13 is also arranged on the lower part of the plug removing and plugging mechanism 11.

[0052] The bottle feeding mechanism 1, plug feeding and plugging mechanism 7, nitrogen filling mechanism 5, plug feeding and plugging head 8, bottle moving mechanism 6, plug taking and plugging mechanism 11, filling and nitrogen filling mechanism 12, plug taking and plugging head 13, bottle discharging mechanism 15 and finished bottle discharging mechanism 17 used in this embodiment are all conventional components. The bottle moving mechanism 6, the bottle discharging mechanism 15 and the finished bottle discharging mechanism 17 all adopt linear conveying mechanisms.

[0053] When in use, first, the clean liquid medicine bottle 2 is sent from the right end of the bottle feeding mechanism 1 to the left to the nitrogen filling station 10, the plugging head 8 of the plugging and plugging mechanism 7 and the lower part of the nitrogen filling mechanism 5. At the same time, the bottle plug 9 is also transported by the plugging and plugging mechanism 7 to the lower end of the plugging and plugging head 8; then, the nitrogen filling mechanism 5 placed on the upper part of the liquid medicine bottle 2 is inserted downward into the bottle of the liquid medicine bottle 2, and nitrogen gas is started to be flushed into the bottle (the time is usually controlled within 1-10 seconds, and the pressure of the nitrogen gas is 5K Pa-50KPa), after the bottle is filled with nitrogen, the nitrogen filling mechanism 5 is withdrawn upward, and then the plug-in and plug-pressing head 8 quickly presses the bottle plug 9 at its lower end into the bottle mouth of the liquid medicine bottle 2 downward. At this time, the liquid medicine bottle 2 is filled with nitrogen; thereafter, the bottle-moving mechanism 6 transfers the liquid medicine bottle 2 filled with nitrogen to the filling station 14, the plug-taking and plug-pressing head 13 at the lower part of the plug-taking and plug-pressing mechanism 11 and the lower part of the filling and nitrogen filling mechanism 12. During this transfer process, due to the liquid medicine bottle 2 The mouth of the liquid bottle 2 is plugged with a bottle stopper 9, so that the nitrogen in the liquid medicine bottle 2 will not escape; then, the plug removal and pressing head 13 at the lower part of the plug removal and pressing mechanism 11 moves downward to the upper end of the liquid medicine bottle 2, so that the lower end of the plug removal and pressing head 13 contacts the bottle stopper 9 at the upper end of the liquid medicine bottle 2 and sucks the bottle stopper 9, then, the plug removal and pressing head 13 removes the bottle stopper 9 and moves upward with the bottle stopper 9, then, the filling and nitrogen charging mechanism 12 is inserted downward into the liquid medicine bottle 2 from which the bottle stopper 9 has been removed In the liquid bottle 2, the liquid medicine begins to be poured into the bottle, and the filling and nitrogen filling mechanism 12 also fills nitrogen into the bottle while pouring the liquid medicine, so as to prevent the air outside the bottle from invading the bottle due to its greater specific gravity than nitrogen. At the same time, during the pouring process, since the bottle is originally full of nitrogen, and nitrogen continues to be filled into the bottle during the pouring, the poured liquid medicine has no chance to contact the air at all, so the residual oxygen in the poured liquid medicine is very small. When the liquid medicine poured into the bottle reaches the set dosage, the filling and nitrogen filling mechanism 12 is withdrawn upward, and at the same time, the plug removal and pressing head 13 quickly moves downward to the upper end of the liquid medicine bottle 2 with the originally removed bottle plug 9, and presses the bottle plug 9 (i.e., the original bottle plug) into the bottle mouth of the liquid medicine bottle 2 again to complete the filling and sealing. At this time, the nitrogen used to protect the liquid medicine is still retained in the cavity in the upper part of the bottle. Afterwards, the bottle discharging mechanism 15 transfers the filled and sealed medicine bottle 2 to the finished product bottle discharging mechanism 17 on its left, and the finished product bottle discharging mechanism 17 delivers it. Since the bottle feeding mechanism 1, the bottle moving mechanism 6 and the bottle discharging mechanism 15 all adopt linear conveying mechanisms, the laminar air will not generate vortexes in the working chamber of the entire device.

[0054] Embodiment 2:

[0055] The novel filling and nitrogen charging device of this embodiment is an improved solution of the embodiment 1, and the difference between the embodiment 1 and the embodiment 1 is that a pre-nitrogen charging station 4 is further provided between the bottle feeding mechanism 1 and the nitrogen charging station 10 (i.e., at the rear end of the bottle feeding mechanism 1, or at the left end of the bottle feeding mechanism 1), and a pre-nitrogen charging mechanism 3 is further provided in the pre-nitrogen charging station 4, and the pre-nitrogen charging mechanism 3 is provided at the upper part of the left end of the bottle feeding mechanism 1. In the pre-nitrogen charging station 4, the transfer of the liquid medicine bottle 2 still depends on the bottle feeding mechanism 1.

[0056] When in use, first, the clean medicine liquid bottle 2 is sent to the left from the right end of the bottle feeding mechanism 1 to the pre-nitrogen filling station 4 and the lower part of the pre-nitrogen filling mechanism 3; then, the pre-nitrogen filling mechanism 3 placed on the upper part of the medicine liquid bottle 2 is inserted downward into the bottle of the medicine liquid bottle 2, and nitrogen begins to be injected into the bottle (the time is usually controlled within 1-5 seconds, and the pressure of the nitrogen is 5KPa-50KPa). After the nitrogen in the bottle is basically full, the pre-nitrogen filling mechanism 3 is withdrawn upward. At this time, the medicine liquid bottle 2 is full of nitrogen, which can prevent it from entraining air in the process of being sent to the nitrogen filling station 10 later; then, the medicine liquid bottle 2 that has been pre-filled with nitrogen continues to be sent to the left by the bottle feeding mechanism 1 to the nitrogen filling station 10.

[0057] The subsequent steps of nitrogen filling and plugging are basically the same as those in Example 1 and will not be described in detail here.

[0058] The novel method and equipment for filling and protecting liquid medicine with nitrogen can be used for nitrogen filling and protecting high value-added products such as glucose, antibiotics, amino acids, fat emulsions, oral liquids, nutrient solutions and biological preparations.

Claims

1. A novel method for filling nitrogen-filled protective liquid medicine, characterized in that: The filling and nitrogen filling process is as follows: A. Bottle delivery and plug delivery: First, the bottle feeding mechanism delivers the clean liquid medicine bottle to the nitrogen filling station, and at the same time, the plug feeding and plug pressing mechanism delivers the bottle plug to the top of the liquid medicine bottle for standby use; B. Nitrogen filling and plugging: Afterwards, insert the nitrogen filling mechanism into the medicine bottle and fill it with nitrogen. After the nitrogen in the medicine bottle is full and the nitrogen filling mechanism is pulled out of the bottle mouth, the plugging and plugging mechanism quickly presses the bottle plug down into the bottle mouth for standby use; C. Station transfer: Afterwards, the bottle transfer mechanism transfers the nitrogen-filled and stoppered medicine bottles from the nitrogen filling station to the filling station for standby use; D. Remove the plug and fill: Afterwards, the plug-removing and plug-pressing mechanism removes the plug of the medicine bottle filled with nitrogen and places it on the top of the medicine bottle. Then, the filling and nitrogen-filling mechanism inserts its filling and nitrogen-filling tube into the medicine bottle and fills the medicine bottle with the medicine. Nitrogen is also filled into the bottle during the filling process. When the filling and nitrogen-filling process is completed, the filling and nitrogen-filling tube is pulled out of the bottle mouth and put into standby use. E. Re-corking: After the filling nitrogen tube is pulled out of the bottle mouth, the cork-taking and corking mechanism will quickly press the original bottle cork placed on the top of the liquid medicine bottle back into the bottle mouth for use; F. Bottle discharging: Afterwards, the re-corked medicine liquid bottle is sent by the bottle discharging mechanism to the finished product bottle discharging mechanism, and then sent out by the finished product bottle discharging mechanism.

2. The novel method for filling and protecting the liquid medicine with nitrogen according to claim 1 is characterized in that: A pre-nitrogen filling station is also provided between the bottle feeding mechanism and the nitrogen filling station. When the bottle feeding mechanism delivers the clean medicine liquid bottle to the pre-nitrogen filling station, the pre-nitrogen filling mechanism is inserted into the medicine liquid bottle for pre-nitrogen filling. Thereafter, the bottle feeding mechanism continues to deliver the pre-nitrogen filled medicine liquid bottle to the nitrogen filling station.

3. The novel method for filling and protecting the liquid medicine with nitrogen according to claim 2 is characterized in that: The bottle moving mechanism in the nitrogen filling station is a linear conveying mechanism.

4. A novel filling and nitrogen charging device using the method described in any one of claims 1 to 3, characterized in that: The invention comprises a frame (16), a bottle feeding mechanism (1), a nitrogen filling station (10), a filling station (14) and a finished bottle discharging mechanism (16), wherein the bottle feeding mechanism (1), the nitrogen filling station (7), the filling station (12) and the finished bottle discharging mechanism (17) are arranged in sequence from right to left on the upper part of the frame (16).

5. The novel filling and nitrogen charging device according to claim 4 is characterized in that: The nitrogen charging station (10) comprises a plug-in and plug-pressing mechanism (7), a nitrogen charging mechanism (5) and a bottle moving mechanism (6); the left and right ends of the bottle moving mechanism (6) are respectively connected to the right end of the filling station (14) and the left end of the bottle-in and plug-pressing mechanism (1); the plug-in and plug-pressing mechanism (7) and the nitrogen charging mechanism (5) are arranged on the upper part of the bottle moving mechanism (6); and the plug-in and plug-pressing head (8) is arranged on the lower part of the plug-in and plug-pressing mechanism (7).

6. The novel filling and nitrogen charging device according to claim 5 is characterized in that: The filling station (14) comprises a plug removing and plugging mechanism (11), a filling and nitrogen filling mechanism (12) and a bottle discharging mechanism (15); the left and right ends of the bottle discharging mechanism (15) are respectively connected to the right end of the finished bottle discharging mechanism (17) and the left end of the bottle moving mechanism (6) of the nitrogen filling station (10); the plug removing and plugging mechanism (11) and the filling and nitrogen filling mechanism (12) are arranged on the upper part of the bottle discharging mechanism (15); and the lower part of the plug removing and plugging mechanism (11) is provided with a plug removing and plugging head (13).

7. The novel filling and nitrogen charging device according to claim 6 is characterized in that: A pre-nitrogen filling station (4) is also provided between the bottle feeding mechanism (1) and the nitrogen filling station (10), and the pre-nitrogen filling station (4) further comprises a pre-nitrogen filling mechanism (3), and the pre-nitrogen filling mechanism (3) is provided on the upper part of the bottle feeding mechanism (1).

8. The novel filling and nitrogen charging device according to claim 7 is characterized in that: The bottle moving mechanism (6) is a linear conveying mechanism.

9. The novel filling and nitrogen charging device according to claim 8 is characterized in that: The bottle discharging mechanism (15) is a linear conveying mechanism.

10. The novel filling and nitrogen charging device according to claim 9 is characterized in that: The bottle feeding mechanism (1) and the finished bottle discharging mechanism (17) are both linear conveying mechanisms.

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