Preparation and purification method of high-purity cycleanine

Through multi-step reaction and temperature control in the preparation and purification methods, the problems of low efficiency and high cost of preparation and purification of spiral rings in the prior art are solved, and high purity and high yield preparation of spiral rings in the high purity and high yield are achieved.

CN119661460APending Publication Date: 2025-03-21JIANGSU TIANSHENG PHARMA
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Patent Information

Application Number
CN202411887422.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-20
Publication Date
2025-03-21

AI Technical Summary

Technical Problem

The prior art has problems in the procurement of impure raw materials and multi-step reactions in the preparation and purification of truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated truncated

Method used

A high-purity Rotary Tengyin preparation and purification method is adopted, including TETA.2H2O preparation, ring-closing reaction, hydrolysis reaction, free reaction and purification purification steps. The reaction efficiency and purity are improved by controlling the temperature and adding an appropriate amount of solvent and catalyst.

Benefits of technology

The preparation and purification of high-purity spironin is realized, suitable for industrial production, low cost, easy to mass production, and improve yield and purity.

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Abstract

The invention belongs to the field of medicine preparation and purification, and relates to a preparation and purification method of high-purity cycleanine. The method comprises the following steps: (1) adding triethylene tetramine into a reaction kettle, and slowly adding methylbenzene; (2) adding DMF (Dimethyl Formamide) and TETA.2H2O into a reaction kettle, introducing nitrogen into the reaction kettle, and catalyzing by alkali; (3) carrying out acid hydrolysis on a cyclization product, and filtering and centrifuging; (4) carrying out free reaction on organic alkali and / or inorganic alkali; and (5) refining and purifying. The process is suitable for industrial production, low in cost and easy for batch production.
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