Simulation device and system for simulating flow resistance characteristics of blood in organ

Abstract

The invention provides a simulation device and system for simulating the flow resistance characteristic of blood in an organ. The device comprises a first blood inlet pipeline, a second blood inlet pipeline, a blood outlet pipeline, a connecting piece, a monitoring module, an adjusting module and a control module. And the first blood inlet pipeline and the second blood inlet pipeline are communicated with the bleeding pipeline. The control module is used for adjusting the state of the adjusting module according to the fluid flow parameters monitored by the monitoring module. The precision of the blood flow resistance characteristic simulated by the simulation device is high, and the error between the blood flow resistance characteristic simulated by the simulation device and the actual blood flow resistance characteristic in a living organ tissue blood vessel is greatly reduced; related design parameters of the perfusion device can be adjusted based on the actual blood flow resistance characteristic, simulated by the simulation device, of the target organ in the blood vessel under the flow, so that the perfusion device which meets the use requirements of living organs and is higher in precision can be developed.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a simulation device and system for simulating blood flow resistance characteristics in organs. Background Art

[0002] End-stage liver disease (chronic liver failure) is a serious, life-threatening liver disease that may be caused by a variety of liver diseases, such as cirrhosis, liver cancer, etc. Since there is currently no effective treatment clinically, patients generally require liver transplantation.

[0003] A liver transplant is the replacement of a diseased liver with a healthy liver from another person. The entire liver or just a portion of it can be transplanted. In most cases, the healthy liver will come from a recently deceased organ donor, although sometimes a healthy person will donate a portion of their liver.

[0004] The liver has three main blood vessels. The hepatic artery is a branch from the celiac artery, which is responsible for transporting oxygen-rich blood from the heart to the liver; the portal vein is responsible for collecting nutrient-rich venous blood from abdominal organs such as the gastrointestinal tract, spleen and pancreas, and transporting it to the liver for metabolism and detoxification; the hepatic vein is responsible for transporting processed blood from the liver back to the inferior vena cava, and finally back to the heart.

[0005] Normothermic mechanical perfusion of the liver is to perfuse the donor liver with a perfusion fluid containing nutrients and oxygen at close to body temperature through mechanical equipment to simulate a normal physiological state. This perfusion method can effectively reduce non-ischemic heat damage to the organ, repair and improve the liver, evaluate the activity of the organ, and effectively improve the success rate of liver transplantation.

[0006] During the development of the normothermic mechanical perfusion system for the liver, the fluid circulation loop control of the normothermic mechanical perfusion system for the liver is relatively complex, and the fluid control function of the circulation system needs to be continuously tested during the design and development process. However, due to factors such as the difficulty in obtaining organs, the difficulty in preserving organ status, and the complexity of operation and maintenance, it is impossible to use living human organs for testing and development.

[0007] At present, in the process of developing the normothermic mechanical perfusion system for the liver, the following methods are usually used for testing: First, animal organs are used for testing and development, but animal organs cannot accurately simulate the blood flow resistance characteristics of the blood vessels in the living liver tissue of the human body; second, the blood flow resistance of the human liver is simply simulated by using tube clamps to change the tube diameter, which is quite different from the resistance characteristics of the living human liver and is difficult to accurately simulate the resistance characteristics of the liver. Therefore, the normothermic mechanical perfusion system for the liver developed based on the above test methods cannot meet the actual use needs. Summary of the invention

[0008] In order to solve the above problems, the present invention proposes a simulation device and system for simulating the blood flow resistance characteristics in an organ.

[0009] In a first aspect, the present invention proposes a simulation device for simulating blood flow resistance characteristics in an organ, which includes a first blood vessel inlet channel, a second blood vessel inlet channel, a bleeding duct, a connector, a monitoring module, a regulating module, and a control module. The first blood vessel inlet channel and the second blood vessel inlet channel are both connected to the bleeding duct through the connector. The monitoring module is used to monitor the fluid flow parameters in the first blood vessel inlet channel, the second blood vessel inlet channel, and the bleeding duct. The regulating module is connected to two of the first blood vessel inlet channel, the second blood vessel inlet channel, and the bleeding duct. The control module is connected to the monitoring module and the regulating module, and is used to adjust the state of the regulating module according to the fluid flow parameters monitored by the monitoring module, so that the fluid flow parameters in the first blood vessel inlet channel and the second blood vessel inlet channel can be consistent with the blood flow resistance characteristics in the target organ.

[0010] Furthermore, the control module includes a control circuit board and a display operation panel, the control circuit board is connected to the monitoring module and the adjustment module, and the display operation panel is connected to the control circuit board. The display operation panel is used to set a blood flow resistance characteristic curve in the target organ, and the control circuit board is used to adjust the state of the adjustment module according to the blood flow resistance characteristic curve in the target organ and the fluid flow parameters monitored by the monitoring module, so that the fluid flow parameters in the first blood inlet channel and the second blood inlet channel can be consistent with the blood flow resistance characteristics in the target organ.

[0011] Further, the monitoring module includes a first monitoring unit, a second monitoring unit and a third monitoring unit. The first monitoring unit is arranged on the first blood vessel inlet channel, and is used to monitor the fluid flow parameters in the first blood vessel inlet channel. The second monitoring unit is arranged on the second blood vessel inlet channel, and is used to monitor the fluid flow parameters in the second blood vessel inlet channel. The third monitoring unit is arranged on the bleeding duct, and is used to monitor the fluid flow parameters in the bleeding duct. The control circuit board is connected to the first monitoring unit, the second monitoring unit and the third monitoring unit, and is used to adjust the state of the adjustment module according to the blood flow resistance characteristic curve in the target organ and the fluid flow parameters monitored by the first monitoring unit, the second monitoring unit and the third monitoring unit, so that the fluid flow parameters in the first blood vessel inlet channel and the second blood vessel inlet channel can be consistent with the blood flow resistance characteristics in the target organ.

[0012] Further, the regulating module includes a first control valve and a second control valve, and the first blood inlet channel, the second blood inlet channel, and the bleeding duct are respectively connected to the first control valve and the second control valve. The control circuit board is connected to the first control valve and the second control valve, and is used to adjust the valve opening of the first control valve and / or the second control valve according to the blood flow resistance characteristic curve in the target organ and the fluid flow parameters monitored by the first monitoring unit, the second monitoring unit, and the third monitoring unit, so that the fluid flow parameters in the first blood inlet channel and the second blood inlet channel can be consistent with the blood flow resistance characteristics in the target organ.

[0013] Further, the first control valve is arranged on the first blood inlet channel, and the second control valve is arranged on the second blood inlet channel.

[0014] Further, the first monitoring unit includes a first pressure sensor and a first flow sensor, the second monitoring unit includes a second pressure sensor and a second flow sensor, and the third monitoring unit includes a third pressure sensor. The blood flow resistance characteristic curve in the target organ is a relationship curve between ΔP and flow Q, the data monitored by the first pressure sensor, the second pressure sensor and the third pressure sensor are P1, P2 and P3 respectively, and the data monitored by the first flow sensor and the second flow sensor are Q1 and Q2 respectively. According to the blood flow resistance characteristic curve in the target organ, ΔP13' corresponding to Q1 and ΔP23' corresponding to Q2 can be obtained, and the control circuit board is configured to be able to adjust the opening of the first control valve and / or the opening of the second control valve based on the relationship between ΔP13=P1-P3 and ΔP13' and the relationship between ΔP23=P2-P3 and ΔP23', until ΔP13=ΔP13', ΔP23=ΔP23', so that the fluid flow parameter P1 of the first blood inlet channel and the fluid flow parameter P2 in the second blood inlet channel are consistent with the blood flow resistance characteristic in the target organ.

[0015] Furthermore, the first control valve is arranged on the first blood vessel inlet channel or the second blood vessel inlet channel, and the second control valve is arranged on the bleeding duct.

[0016] Further, the first monitoring unit includes a first pressure sensor and a first flow sensor, the second monitoring unit includes a second pressure sensor, and the third monitoring unit includes a third pressure sensor and a third flow sensor. The blood flow resistance characteristic curve in the target organ is a relationship curve between ΔP and flow Q, the data monitored by the first pressure sensor, the second pressure sensor, and the third pressure sensor are P1, P2, and P3, respectively, and the data monitored by the first flow sensor and the third flow sensor are Q1 and Q3, respectively. Among them, according to the blood flow resistance characteristic curve in the target organ, △P13' corresponding to Q1 and △P23' corresponding to Q3-Q1 can be obtained, and the control circuit board is configured to be able to adjust the opening of the first control valve and / or the opening of the second control valve based on the relationship between △P13=P1-P3 and △P13' and the relationship between △P23=P2-P3 and △P23', until △P13=△P13', △P23=△P23', so that the fluid flow parameter P1 of the first blood vessel inlet channel and the fluid flow parameter P2 in the second blood vessel inlet channel are consistent with the blood flow resistance characteristics in the target organ.

[0017] Further, the first pressure sensor, the second pressure sensor, or the third pressure sensor is a contact pressure sensor; and / or The first flow sensor, the second flow sensor, or the third flow sensor is a non-contact flow sensor.

[0018] Furthermore, the first control valve or the second control valve is a contact electric valve or a non-contact electric pipe clamp valve.

[0019] In a second aspect, the present invention proposes a simulation system for simulating the blood flow resistance characteristics in an organ, which includes a perfusion device and the simulation device for simulating the blood flow resistance characteristics in an organ as described above, wherein the simulation device receives fluid flowing out of the perfusion device and simulates the blood flow resistance characteristics in the target organ.

[0020] The beneficial effects of the present invention are as follows: In the present application, the blood flow in the blood vessels of the target organ (such as the liver) with double blood inlets and a single blood outlet can be simulated through the first blood inlet channel, the second blood inlet channel and the bleeding conduit, and the fluid flow parameters in the first blood inlet channel and the second blood inlet channel can be controlled based on the blood flow resistance characteristics in the target organ until they are consistent with the blood flow resistance characteristics in the target organ through the cooperation between the monitoring module, the regulating module and the control module. In addition, since the simulation device of the present application can simulate the blood flow resistance characteristics in the blood vessels of the target organ, and the simulated blood flow resistance characteristics are highly accurate, the error between the blood flow resistance characteristics and the actual blood flow resistance characteristics in the blood vessels of living organ tissues is greatly reduced, so when it is connected to the perfusion device and the development test of the perfusion device is performed, the relevant design parameters of the perfusion device can be adjusted based on the actual blood flow resistance characteristics in the blood vessels of the target organ simulated by the simulation device at the flow rate, so that a perfusion device that meets the use requirements of living organs and has higher accuracy can be developed, thereby reducing product development costs and accelerating product development cycles.

[0021] This Summary is provided to introduce a selection of concepts in a simplified form that are further described below in the Detailed Description. This Summary is not intended to identify key features or essential features of the disclosure, nor is it intended to limit the scope of the disclosure. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] The above and other objects, features and advantages of the present disclosure will become more apparent through a more detailed description of exemplary embodiments of the present disclosure in conjunction with the accompanying drawings, wherein like reference numerals generally represent like components throughout the exemplary embodiments of the present disclosure.

[0023] Figure 1 A schematic structural diagram of a simulation system for simulating blood flow resistance characteristics in an organ according to the present invention is shown; Figure 2 A schematic diagram showing the structural connections of a simulation device for simulating blood flow resistance characteristics in an organ according to the present invention; Figure 3 A schematic diagram of the structural connections of another simulation device for simulating the blood flow resistance characteristics in an organ of the present invention is shown.

[0024] The reference numerals are as follows: 1000, simulation system; 100. Simulation device; 10. First vascular access; 20. Second vascular access; 30. Bleeding duct; 40. Connectors; 50. Monitoring module; 51. First monitoring unit; 511. First pressure sensor; 512. First flow sensor; 52. Second monitoring unit; 521. Second pressure sensor; 522. Second flow sensor; 53. Third monitoring unit; 531. Third pressure sensor; 532. Third flow sensor; 60. regulating module; 61. first control valve; 62. second control valve; 70. control module; 71. control circuit board; 72. display operation panel; A1, first joint; A2, second joint; A3, third joint; 200. Infusion device. DETAILED DESCRIPTION

[0025] Embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although embodiments of the present disclosure are shown in the accompanying drawings, it should be understood that the present disclosure can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided to make the present disclosure more thorough and complete, and to fully convey the scope of the present disclosure to those skilled in the art.

[0026] As used herein, the term "including" and its variations mean open inclusion, i.e., "including but not limited to". Unless otherwise stated, the term "or" means "and / or". The term "based on" means "based at least in part on". The terms "an example embodiment" and "an embodiment" mean "at least one example embodiment". The term "another embodiment" means "at least one additional embodiment". The terms "first", "second", etc. may refer to different or the same objects. Other explicit and implicit definitions may also be included below.

[0027] Refer to the following Figure 1-3 To describe the simulation device and system for simulating the blood flow resistance characteristics in an organ according to an embodiment of the present application.

[0028] Reference Figure 1 The simulation system 1000 of the present application for simulating the blood flow resistance characteristics in an organ includes a perfusion device 200 and a simulation device 100 .

[0029] The perfusion device 200 is used to perfuse a donor organ (such as a liver) with a perfusion fluid containing nutrients and oxygen at a temperature close to body temperature through a mechanical device to simulate the normal physiological state of the organ. The perfusion method performed by the perfusion device 200 can effectively reduce ischemic heat damage to the organ, repair and improve the organ, and evaluate the activity of the organ, which can effectively improve the success rate of organ transplantation.

[0030] The simulation device 100 is used to simulate the blood flow resistance characteristics in the organ. In the development and testing process of the perfusion device 200, the simulation device 100 can be connected to the perfusion device 200, and a simulated liquid with a viscosity similar to that of blood is injected into the perfusion device 200 and the perfusion device 200 is turned on for circulation. Then, the simulation device 100 can receive the fluid (a simulated liquid) flowing out of the perfusion device 200 and simulate the actual blood flow resistance characteristics of the blood vessels of the organ at the flow rate through the fluid, so that the relevant design parameters of the perfusion device 200 can be adjusted based on the actual blood flow resistance characteristics of the blood vessels of the organ at the flow rate simulated by the simulation device 100, thereby developing a perfusion device 200 that meets the use requirements of living organs and has higher accuracy.

[0031] Reference Figure 2 and Figure 3 The simulation device 100 for simulating the blood flow resistance characteristics in an organ of the present application includes a first blood vessel inlet 10, a second blood vessel inlet 20, a bleeding conduit 30, a connector 40, a monitoring module 50, a regulating module 60 and a control module 70.

[0032] The first blood vessel access channel 10 and the second blood vessel access channel 20 are both connected to the bleeding duct 30 through the connector 40. The monitoring module 50 is used to monitor the fluid flow parameters in the first blood vessel access channel 10, the second blood vessel access channel 20 and the bleeding duct 30. The regulating module 60 is connected to two of the first blood vessel access channel 10, the second blood vessel access channel 20 and the bleeding duct 30.

[0033] The control module 70 is connected to the monitoring module 50 and the regulating module 60, and is used to adjust the state of the regulating module 60 according to the fluid flow parameters monitored by the monitoring module 50, so that the fluid flow parameters in the first blood vessel inlet channel 10 and the second blood vessel inlet channel 20 can be consistent with the blood flow resistance characteristics in the target organ.

[0034] It should be noted that the fluid flow parameters in the first blood vessel inlet channel 10 and the second blood vessel inlet channel 20 are parameters that can characterize the blood flow resistance characteristics in the simulated target organ blood vessel. Conversely, based on the blood flow resistance characteristics in the simulated target organ blood vessel, the fluid flow parameters in the first blood vessel inlet channel 10 and the second blood vessel inlet channel 20 can be adjusted until they are consistent with the blood flow parameters corresponding to the blood flow resistance characteristics in the target organ blood vessel.

[0035] Therefore, in this embodiment, the blood flow condition in the blood vessel of the target organ (such as the liver) having dual blood inlets and a single blood outlet can be simulated through the first blood vessel inlet channel 10, the second blood vessel inlet channel 20 and the bleeding conduit 30, and the coordination among the monitoring module 50, the regulating module 60 and the control module 70 can control the fluid flow parameters in the first blood vessel inlet channel 10 and the second blood vessel inlet channel 20 based on the blood flow resistance characteristics in the target organ until they are consistent with the blood flow resistance characteristics in the target organ (i.e., consistent with the blood flow parameters corresponding to the blood flow resistance characteristics in the blood vessel of the target organ).

[0036] Furthermore, since the simulation device 100 of the present application can simulate the blood flow resistance characteristics in the blood vessels of the target organ, and the simulated blood flow resistance characteristics are highly accurate, the error between the actual blood flow resistance characteristics in the blood vessels of living organ tissues is greatly reduced. Therefore, when it is connected to the perfusion device 200 and the development test of the perfusion device 200 is performed, the relevant design parameters of the perfusion device 200 can be adjusted based on the actual blood flow resistance characteristics in the blood vessels of the target organ at the flow rate simulated by the simulation device 100, thereby being able to develop a perfusion device 200 that meets the use requirements of living organs and has higher accuracy, thereby reducing product development costs and accelerating the product development cycle.

[0037] Reference Figure 2 and Figure 3 The control module 70 includes a control circuit board 71 and a display operation panel 72 . The control circuit board 71 is connected to the monitoring module 50 and the adjustment module 60 , and the display operation panel 72 is connected to the control circuit board 71 .

[0038] The display operation panel 72 is used to set the blood flow resistance characteristic curve in the target organ. Specifically, the user can directly input the blood flow resistance characteristic curve in the target organ on the interface of the display operation panel 72, or directly call the built-in blood flow resistance characteristic curve in the target organ.

[0039] The blood flow resistance characteristic curve in the target organ may have different characteristic curves due to the influence of the organ volume, the organ physiological state, etc., and may be selected based on actual needs. For example, the blood flow resistance characteristic curve in the target organ may be a relationship curve between ΔP and flow rate Q, where ΔP is the blood inlet and outlet pressure difference in the target organ tissue blood vessels, and Q is the blood flow rate in the target organ blood vessels.

[0040] The control circuit board 71 is used to adjust the state of the adjustment module 60 according to the blood flow resistance characteristic curve in the target organ and the fluid flow parameters monitored by the monitoring module 50, so that the fluid flow parameters of the first blood vessel inlet channel 10 and the second blood vessel inlet channel 20 can be consistent with the blood flow resistance characteristics in the target organ.

[0041] In this embodiment, the display operation panel 72 allows the user to independently select and determine the blood flow resistance characteristics of the target organ according to his or her own needs, and utilizes the cooperation between the control circuit board 71 and the monitoring module 50 and the adjustment module 60 to adjust the state of the adjustment module 60 so that the fluid flow parameters of the first blood inlet channel 10 and the second blood inlet channel 20 can be consistent with the blood flow resistance characteristics in the target organ, thereby allowing the simulation device 100 of the present application to be used to simulate organs of various volumes and various physiological states, with wider applicability and higher accuracy.

[0042] Reference Figure 2 and Figure 3 The monitoring module 50 includes a first monitoring unit 51 , a second monitoring unit 52 and a third monitoring unit 53 .

[0043] The first monitoring unit 51 is disposed on the first blood inlet channel 10 and is used to monitor the fluid flow parameters in the first blood inlet channel 10 .

[0044] The second monitoring unit 52 is disposed on the second blood inlet channel 20 and is used to monitor the fluid flow parameters in the second blood inlet channel 20 .

[0045] The third monitoring unit 53 is disposed on the bleeding tube 30 and is used to monitor the fluid flow parameters in the bleeding tube 30 .

[0046] The control circuit board 71 is connected to the first monitoring unit 51, the second monitoring unit 52, and the third monitoring unit 53, and is used to adjust the state of the adjustment module 60 according to the blood flow resistance characteristic curve in the target organ and the fluid flow parameters monitored by the first monitoring unit 51, the second monitoring unit 52, and the third monitoring unit 53, so that the fluid flow parameters in the first blood inlet channel 10 and the second blood inlet channel 20 can be consistent with the blood flow resistance characteristics in the target organ.

[0047] In this embodiment, based on the cooperation of the first monitoring unit 51, the second monitoring unit 52 and the third monitoring unit 53, the fluid flow parameters in two blood inlet channels and one bleeding duct can be monitored respectively, so that the fluid flow parameters in each blood inlet channel can be finely adjusted based on the parameter difference between each blood inlet channel and the bleeding duct, thereby improving the simulation accuracy of the simulation device 100 of the present application on the blood flow resistance characteristics in the target organ blood vessels.

[0048] Reference Figure 2 and Figure 3 The regulating module 60 includes a first control valve 61 and a second control valve 62, and two of the first blood vessel inlet channel 10, the second blood vessel inlet channel 20, and the bleeding conduit 30 are connected to the first control valve 61 and the second control valve 62, respectively.

[0049] Specifically, the first control valve 61 can be disposed on the first blood inlet channel 10, and the second control valve 62 can be disposed on the second blood inlet channel 20. Figure 2 As shown; of course, the first control valve 61 can be set on the first vascular access channel 10 or the second vascular access channel 20, and the second control valve 82 is set on the bleeding conduit 30.

[0050] The control circuit board 71 is connected to the first control valve 61 and the second control valve 62, and is used to adjust the valve opening of the first control valve 61 and / or the second control valve 62 according to the blood flow resistance characteristic curve in the target organ and the fluid flow parameters monitored by the first monitoring unit 51, the second monitoring unit 52, and the third monitoring unit 53, so that the fluid flow parameters in the first blood inlet channel 10 and the second blood inlet channel 20 can be consistent with the blood flow resistance characteristics in the target organ.

[0051] In this embodiment, by controlling the valve opening of the first control valve 61 and / or the second control valve 62 by the control circuit board 71, fine adjustment of the fluid flow parameters in the first blood vessel inlet channel 10 and the second blood vessel inlet channel 20 can be achieved, so that the fluid flow parameters in the first blood vessel inlet channel 10 and the second blood vessel inlet channel 20 can be consistent with the blood flow resistance characteristics in the target organ, thereby helping to improve the simulation accuracy of the blood flow resistance characteristics in the target organ blood vessels by the simulation device 100 of the present application.

[0052] Reference Figure 2 The first control valve 61 is disposed on the first blood inlet channel 10, and the second control valve 62 is disposed on the second blood inlet channel 20. The first monitoring unit 51 includes a first pressure sensor 511 and a first flow sensor 512, the second monitoring unit 52 includes a second pressure sensor 521 and a second flow sensor 522, and the third monitoring unit 53 includes a third pressure sensor 531.

[0053] The blood flow resistance characteristic curve in the target organ is a relationship curve between ΔP and flow rate Q. The data monitored by the first pressure sensor 511, the second pressure sensor 521 and the third pressure sensor 531 are P1, P2 and P3 respectively, and the data monitored by the first flow sensor 512 and the second flow sensor 522 are Q1 and Q2 respectively. According to the blood flow resistance characteristic curve in the target organ, ΔP13' corresponding to Q1 and ΔP23' corresponding to Q2 can be obtained.

[0054] The control circuit board 71 is configured to be able to adjust the opening of the first control valve 61 and / or the opening of the second control valve 62 based on the relationship between △P13=P1-P3 and △P13' and the relationship between △P23=P2-P3 and △P23' until △P13=△P13', △P23=△P23', so that the fluid flow parameter P1 of the first vascular inlet channel 10 and the fluid flow parameter P2 in the second vascular inlet channel 20 are consistent with the blood flow resistance characteristics in the target organ.

[0055] In this embodiment, for the first blood vessel inlet channel 10, after the first flow sensor 512 on the first blood vessel inlet channel 10 detects the fluid flow Q1, the first pressure sensor 511 detects the fluid pressure P1, and the third pressure sensor 531 detects the fluid pressure P3, the control circuit board 71 calculates the pressure difference △P13=P1-P3 in the first blood vessel inlet channel 10, and obtains the target pressure difference △P13' corresponding to the fluid flow Q1 according to the blood flow resistance characteristic curve in the target organ. When △P13≠△P13', the control circuit board 71 sends a control signal through the built-in algorithm to adjust the opening of the first control valve 61 until △P13=△P13', thereby simulating the actual blood flow resistance characteristics in the blood vessels of the organ under the fluid flow Q1.

[0056] For the second blood vessel inlet channel 20, after the second flow sensor 522 on the second blood vessel inlet channel 20 detects the fluid flow Q2, the second pressure sensor 521 detects the fluid pressure P2, and the third pressure sensor 531 detects the fluid pressure P3, the control circuit board 71 calculates the pressure difference △P23=P2-P3 in the second blood vessel inlet channel 20, and obtains the target pressure difference △P23' corresponding to the fluid flow Q2 according to the blood flow resistance characteristic curve in the target organ. When △P23≠△P23', the control circuit board 71 sends a control signal through the built-in algorithm to adjust the opening of the second control valve 62 until △P23=△P23', thereby simulating the actual blood flow resistance characteristics in the blood vessels of the organ under the fluid flow Q2.

[0057] Therefore, in this implementation, the actual blood flow resistance characteristics of the target organ under different fluid flow rates can be simulated in the above manner with high simulation accuracy, which greatly reduces the error between the actual blood flow resistance characteristics in the blood vessels of living organ tissues, so that when it is connected to the perfusion device 200 and the development test of the perfusion device 200 is performed, the relevant design parameters of the perfusion device 200 can be adjusted based on the actual blood flow resistance characteristics in the blood vessels of the target organ at the flow rate simulated by the simulation device 100, so that a perfusion device 200 that meets the use requirements of living organs and has higher accuracy can be developed, thereby reducing product development costs and accelerating the product development cycle.

[0058] Reference Figure 3 The first control valve 61 is disposed on the first blood inlet channel 10, and the second control valve 82 is disposed on the bleeding conduit 30. The first monitoring unit 51 includes a first pressure sensor 511 and a first flow sensor 512, the second monitoring unit 52 includes a second pressure sensor 521, and the third monitoring unit 53 includes a third pressure sensor 531 and a third flow sensor 532.

[0059] The blood flow resistance characteristic curve in the target organ is a relationship curve between ΔP and flow rate Q. The data monitored by the first pressure sensor 511, the second pressure sensor 521 and the third pressure sensor 531 are P1, P2 and P3 respectively, and the data monitored by the first flow sensor 512 and the third flow sensor 532 are Q1 and Q3 respectively. According to the blood flow resistance characteristic curve in the target organ, ΔP13' corresponding to Q1 and ΔP23' corresponding to Q3-Q1 can be obtained.

[0060] The control circuit board 71 is configured to be able to adjust the opening of the first control valve 61 and / or the opening of the second control valve 62 based on the relationship between △P13=P1-P3 and △P13' and the relationship between △P23=P2-P3 and △P23' until △P13=△P13', △P23=△P23', so that the fluid flow parameter P1 of the first vascular inlet channel 10 and the fluid flow parameter P2 in the second vascular inlet channel 20 are consistent with the blood flow resistance characteristics in the target organ.

[0061] In this embodiment, for the first blood vessel inlet channel 10, after the first flow sensor 512 on the first blood vessel inlet channel 10 detects the fluid flow Q1, the first pressure sensor 511 detects the fluid pressure P1, and the third pressure sensor 531 detects the fluid pressure P3, the control circuit board 71 calculates the pressure difference △P13=P1-P3 in the first blood vessel inlet channel 10, and obtains the target pressure difference △P13' corresponding to the fluid flow Q1 according to the blood flow resistance characteristic curve in the target organ. When △P13≠△P13', the control circuit board 71 sends a control signal through the built-in algorithm to adjust the opening of the first control valve 61 until △P13=△P13'.

[0062] For the second blood inlet channel 20, after the third flow sensor 532 on the bleeding conduit 30 detects the fluid flow Q3, the second pressure sensor 521 detects the fluid pressure P2, and the third pressure sensor 531 detects the fluid pressure P3, the control circuit board 71 calculates the pressure difference △P23=P2-P3 in the second blood inlet channel 20, and obtains the target pressure difference △P23' corresponding to the fluid flow Q3-Q1 according to the blood flow resistance characteristic curve in the target organ. When △P23≠△P23', the control circuit board 71 sends a control signal through the built-in algorithm , adjust the opening of the second control valve 62 until △P23=△P23'; at the same time, since the second control valve 62 is arranged on the bleeding duct 30, the opening adjustment of the second control valve 62 will also cause the blood flow resistance characteristics in the first blood inlet channel 10 to change. Further, the control circuit board 71 sends a control signal through the built-in algorithm to adjust the opening of the first control valve 61 until △P13=△P13', thereby finally adjusting the blood flow resistance characteristics in the first blood inlet channel 10 and the second blood inlet channel 20 to be consistent with the blood flow resistance characteristics in the target organ.

[0063] Therefore, in this implementation, the actual blood flow resistance characteristics of the target organ simulated in the above manner at the corresponding fluid flow rate are more accurate, which greatly reduces the error between the actual blood flow resistance characteristics in the blood vessels of living organ tissues, so that when it is connected to the perfusion device 200 and the development test of the perfusion device 200 is performed, the relevant design parameters of the perfusion device 200 can be adjusted based on the actual blood flow resistance characteristics in the blood vessels of the target organ at the flow rate simulated by the simulation device 100, so that a perfusion device 200 that meets the use requirements of living organs and has higher accuracy can be developed, thereby reducing product development costs and accelerating the product development cycle.

[0064] In some embodiments, in order to improve the sealing performance of the tubes at the connection positions, the first blood vessel access channel 10, the second blood vessel access channel 20 and the bleeding tube 30 may be silicone tubes.

[0065] In some embodiments, in order to improve the accuracy of pressure detection in the pipeline, the first pressure sensor 511, the second pressure sensor 521, or the third pressure sensor 531 may be a contact pressure sensor.

[0066] In some embodiments, the first flow sensor 512, the second flow sensor 522, or the third flow sensor 532 is a non-contact flow sensor.

[0067] The first control valve 61 and the second control valve 62 are valve mechanisms capable of adjusting flow rates. Specifically, the first control valve 61 and the second control valve 62 may be contact-type electric valves or non-contact-type electric pipe clamp valves.

[0068] In some embodiments, reference Figure 2 and Figure 3 The connecting piece 40 is a three-way connector. The first blood inlet channel 10 can be connected to the outlet of the perfusion device 200 through the first connector A1, the second blood inlet channel 20 can be connected to the outlet of the perfusion device 200 through the second connector A2, and the bleeding conduit 30 can be connected to the inlet of the perfusion device 200 through the third connector A3 to realize the circulation of fluid between the perfusion device 200 and the simulation device 100.

[0069] The embodiments of the present disclosure have been described above, and the above description is exemplary, not exhaustive, and is not limited to the disclosed embodiments. Many modifications and changes will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The selection of terms used herein is intended to best explain the principles of the embodiments, practical applications, or technical improvements in the market, or to enable other persons of ordinary skill in the art to understand the embodiments disclosed herein.

Claims

1. A simulation device (100) for simulating blood flow resistance characteristics in an organ, characterized in that: The simulation device (100) comprises a first blood vessel access channel (10), a second blood vessel access channel (20), a bleeding conduit (30), a connecting piece (40), a monitoring module (50), a regulating module (60), and a control module (70); The first blood vessel inlet channel (10) and the second blood vessel inlet channel (20) are both connected to the bleeding duct (30) via the connecting piece (40); The monitoring module (50) is used to monitor fluid flow parameters in the first blood vessel access channel (10), the second blood vessel access channel (20) and the bleeding duct (30); The regulating module (60) is connected to two of the first blood vessel inlet channel (10), the second blood vessel inlet channel (20), and the bleeding duct (30); The control module (70) is connected to the monitoring module (50) and the regulating module (60) and is used to adjust the state of the regulating module (60) according to the fluid flow parameters monitored by the monitoring module (50), so that the fluid flow parameters in the first blood vessel inlet channel (10) and the second blood vessel inlet channel (20) can be consistent with the blood flow resistance characteristics in the target organ.

2. The simulation device (100) for simulating blood flow resistance characteristics in an organ according to claim 1, characterized in that: The control module (70) comprises a control circuit board (71) and a display operation panel (72), wherein the control circuit board (71) is connected to the monitoring module (50) and the regulating module (60), and the display operation panel (72) is connected to the control circuit board (71); The display operation panel (72) is used to set a blood flow resistance characteristic curve in a target organ, and the control circuit board (71) is used to adjust the state of the adjustment module (60) according to the blood flow resistance characteristic curve in the target organ and the fluid flow parameters monitored by the monitoring module (50), so that the fluid flow parameters in the first blood inlet channel (10) and the second blood inlet channel (20) can be consistent with the blood flow resistance characteristics in the target organ.

3. The simulation device (100) for simulating blood flow resistance characteristics in an organ according to claim 2, characterized in that: The monitoring module (50) comprises a first monitoring unit (51), a second monitoring unit (52) and a third monitoring unit (53); The first monitoring unit (51) is arranged on the first blood inlet channel (10) and is used to monitor the fluid flow parameters in the first blood inlet channel (10); The second monitoring unit (52) is arranged on the second blood inlet channel (20) and is used to monitor the fluid flow parameters in the second blood inlet channel (20); The third monitoring unit (53) is arranged on the bleeding duct (30) and is used to monitor the fluid flow parameters in the bleeding duct (30); The control circuit board (71) is connected to the first monitoring unit (51), the second monitoring unit (52), and the third monitoring unit (53), and is used to adjust the state of the adjustment module (60) according to the blood flow resistance characteristic curve in the target organ and the fluid flow parameters monitored by the first monitoring unit (51), the second monitoring unit (52), and the third monitoring unit (53), so that the fluid flow parameters in the first blood vessel inlet channel (10) and the second blood vessel inlet channel (20) can be consistent with the blood flow resistance characteristics in the target organ.

4. The simulation device (100) for simulating blood flow resistance characteristics in an organ according to claim 3, characterized in that: The regulating module (60) comprises a first control valve (61) and a second control valve (62), and two of the first blood vessel inlet channel (10), the second blood vessel inlet channel (20), and the bleeding conduit (30) are respectively connected to the first control valve (61) and the second control valve (62); The control circuit board (71) is connected to the first control valve (61) and the second control valve (62) and is used to adjust the valve opening of the first control valve (61) and / or the second control valve (62) according to the blood flow resistance characteristic curve in the target organ and the fluid flow parameters monitored by the first monitoring unit (51), the second monitoring unit (52) and the third monitoring unit (53), so that the fluid flow parameters in the first blood inlet channel (10) and the second blood inlet channel (20) can be consistent with the blood flow resistance characteristics in the target organ.

5. The simulation device (100) for simulating blood flow resistance characteristics in an organ according to claim 4, characterized in that: The first control valve (61) is arranged on the first blood inlet channel (10), and the second control valve (62) is arranged on the second blood inlet channel (20).

6. The simulation device (100) for simulating blood flow resistance characteristics in an organ according to claim 5, characterized in that: The first monitoring unit (51) comprises a first pressure sensor (511) and a first flow sensor (512); The second monitoring unit (52) comprises a second pressure sensor (521) and a second flow sensor (522); The third monitoring unit (53) comprises a third pressure sensor (531); The blood flow resistance characteristic curve in the target organ is a relationship curve between ΔP and flow rate Q, the data monitored by the first pressure sensor (511), the second pressure sensor (521) and the third pressure sensor (531) are P1, P2 and P3 respectively, and the data monitored by the first flow sensor (512) and the second flow sensor (522) are Q1 and Q2 respectively; According to the blood flow resistance characteristic curve in the target organ, ΔP13' corresponding to Q1 and ΔP23' corresponding to Q2 can be obtained. The control circuit board (71) is configured to be able to adjust the opening of the first control valve (61) and / or the opening of the second control valve (62) based on the relationship between ΔP13=P1-P3 and ΔP13' and the relationship between ΔP23=P2-P3 and ΔP23' until ΔP13=ΔP13' and ΔP23=ΔP23', so that the fluid flow parameter P1 of the first blood inlet channel (10) and the fluid flow parameter P2 in the second blood inlet channel (20) are consistent with the blood flow resistance characteristic in the target organ.

7. The simulation device (100) for simulating blood flow resistance characteristics in an organ according to claim 4, characterized in that: The first control valve (61) is arranged on the first blood vessel inlet channel (10) or the second blood vessel inlet channel (20), and the second control valve (62) is arranged on the bleeding duct (30).

8. The simulation device (100) for simulating blood flow resistance characteristics in an organ according to claim 7, characterized in that: The first monitoring unit (51) comprises a first pressure sensor (511) and a first flow sensor (512); The second monitoring unit (52) comprises a second pressure sensor (521); The third monitoring unit (53) comprises a third pressure sensor (531) and a third flow sensor (532); The blood flow resistance characteristic curve in the target organ is a relationship curve between ΔP and flow rate Q, the data monitored by the first pressure sensor (511), the second pressure sensor (521) and the third pressure sensor (531) are P1, P2 and P3 respectively, and the data monitored by the first flow sensor (512) and the third flow sensor (532) are Q1 and Q3 respectively; According to the blood flow resistance characteristic curve in the target organ, ΔP13' corresponding to Q1 and ΔP23' corresponding to Q3-Q1 can be obtained. The control circuit board (71) is configured to adjust the opening of the first control valve (61) and / or the opening of the second control valve (62) based on the relationship between ΔP13=P1-P3 and ΔP13' and the relationship between ΔP23=P2-P3 and ΔP23' until ΔP13=ΔP13' and ΔP23=ΔP23', so that the fluid flow parameter P1 of the first blood inlet channel (10) and the fluid flow parameter P2 in the second blood inlet channel (20) are consistent with the blood flow resistance characteristic in the target organ.

9. The simulation device (100) for simulating blood flow resistance characteristics in an organ according to claim 6 or 8, characterized in that: The first blood vessel inlet channel (10), the second blood vessel inlet channel (20) and the bleeding duct (30) are silicone tubes; and / or The first pressure sensor (511), the second pressure sensor (521), or the third pressure sensor (531) is a contact pressure sensor; and / or The first flow sensor (512), the second flow sensor (522), or the third flow sensor (532) is a non-contact flow sensor; and / or The first control valve (61) or the second control valve (62) is a contact type electric valve or a non-contact type electric pipe clamp valve.

10. A simulation system for simulating blood flow resistance characteristics in an organ, characterized in that: The simulation system comprises a perfusion device (200) and a simulation device (100) for simulating blood flow resistance characteristics in an organ according to any one of claims 1 to 9, wherein the simulation device (100) receives fluid flowing out of the perfusion device (200) and simulates blood flow resistance characteristics in a target organ.

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