Weight-losing slimming paste and preparation method thereof

Abstract

The invention discloses a slimming patch and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine products, and the method comprises the following steps: weighing bighead atractylodes rhizome, immature bitter orange, poria cocos, dried orange peel, peach kernel, lotus leaf and hawthorn, cleaning, drying and crushing to obtain traditional Chinese medicine powder; adding the traditional Chinese medicine powder into water, uniformly mixing, carrying out ultrasonic treatment, fermenting, carrying out heat treatment, filtering, collecting filtrate and filter residues, and concentrating the filtrate to obtain a concentrate I; carrying out supercritical extraction, filtration and concentration on the filter residue to obtain a concentrate II; uniformly mixing the concentrate I, the concentrate II and a synergistic additive to obtain a traditional Chinese medicine active matter; the traditional Chinese medicine active matter, sodium alginate, sodium carboxymethyl cellulose and water are evenly mixed, a coconut oil film is added for emulsification, a calcium chloride aqueous solution is dropwise added for curing, and the weight-losing pills are obtained and then attached to the center of patch cloth to obtain the weight-losing patch. The prepared weight-losing slimming paste is convenient to use, good in weight-losing effect, stable and lasting, and the weight does not rebound after the slimming paste is not used.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of traditional Chinese medicine products, and particularly relates to a weight loss and slimming patch and a preparation method thereof. BACKGROUND

[0002] The fast pace of life has led to great changes in people's eating habits and lifestyle, resulting in an increasingly serious obesity problem. Obesity not only affects personal appearance, but can also cause a variety of chronic diseases, such as hypertension, diabetes, cardiovascular disease, etc. Nowadays, as people pay more and more attention to health and beauty, weight loss has become a hot topic. People hope to get rid of excess fat and reshape a healthy and beautiful body through scientific and reasonable ways, and to lead a healthier life. In the weight loss market, various weight loss products and methods are emerging in an endless stream, and how to choose a suitable weight loss method has become the focus of many people. Compared with some western medicine weight loss products containing hormone drugs on the market, traditional Chinese medicine weight loss methods are favored by many people who pursue healthy weight loss due to their mild and natural treatment principles. Traditional Chinese medicine weight loss focuses on balancing the body's internal balance, and achieves the weight loss goal through adjusting the functions of viscera, dredging meridians, and improving constitution, etc. The weight loss and slimming patch is based on the meridian theory of traditional Chinese medicine, stimulates specific acupoints of the human body, regulates endocrine, and promotes metabolism, so as to achieve the purpose of weight loss and slimming. The weight loss and slimming patch selects pure natural herbal plants, has no side effects on the human body, is convenient to use, and can play a role only by being pasted on the specified acupoint, without affecting daily life and work. Persistent use can effectively reduce excess fat in the body and achieve the effect of slimming.

[0003] Chinese patent CN105106612A discloses a kind of weight loss slimming paste and its preparation method, mainly including the following raw materials are prepared: Salvia miltiorrhiza, old plum leaf, shen strip, soft jujube, female privet fruit, senna leaf, cecum grass, jasmine, sloe, citron, polygonatum, bergamot, honeysuckle, by the raw material is extracted after being crushed with water to obtain filtrate, under the condition of heating treatment is concentrated to thick paste, after cooling, coat on the paste, cutting is obtained weight loss slimming paste;The weight loss slimming paste of the patent uses traditional Chinese medicine as raw material, safe and no side effect, can be used for a long time, has the effect of invigorating the stomach and regulating menstruation, moistening the intestine and defecation, can improve body function, play a certain weight loss effect.Chinese patent CN105999176A discloses a kind of traditional Chinese medicine body slimming paste and its preparation method, including the following raw materials are made: atractylodes, reed, dogwood, lotus leaf, honeysuckle, chuanxiong, cassia, herba hypericis, shouwu, zizyphi fructus, ginger, the thick paste is obtained after each raw material is extracted, concentrated, filtered and evaporated, the thick paste is coated on the medicinal non-woven fabric, and is cut into convenient-to-use round or square plaster, and is sealed to obtain;The slimming paste of the patent has little side effect, has the effects of reducing blood sugar and blood lipid, antibacterial and anti-inflammatory, clearing heat and detoxifying, nourishing liver and kidney, and can play the curative effect of weight loss and slimming.However, the slimming paste disclosed in the above patent has limited absorption and treatment effect, and the effect is slow, which still needs to be improved. SUMMARY

[0004] In view of the deficiencies in the prior art, the present application provides a kind of weight loss slimming paste, preferably traditional Chinese medicine prescription and adopt specific extraction process to obtain traditional Chinese medicine concentrate, then make weight loss slimming paste by collocating synergistic adjuvant, the absorption and treatment effect of the weight loss slimming paste is good, the weight loss effect is stable and durable, the body weight does not rebound after stopping use, and it is convenient to use.The technical scheme adopted by the present application is as follows:

[0005] A kind of weight loss slimming paste, comprising the following raw materials:

[0006] Atractylodes, bitter orange fruit, Poria cocos, dried tangerine or orange peel, peach kernel, lotus leaf and hawthorn.

[0007] Preferably, a kind of weight loss slimming paste is made from the following raw materials by weight:

[0008] 20-40 parts by weight of atractylodes, 20-40 parts by weight of bitter orange fruit, 10-30 parts by weight of Poria cocos, 10-30 parts by weight of dried tangerine or orange peel, 5-15 parts by weight of peach kernel, 10-30 parts by weight of lotus leaf and 10-30 parts by weight of hawthorn.

[0009] Atractylodes: has the effect of invigorating the spleen and eliminating dampness, can eliminate phlegm and water, promote the health of spleen and stomach, help digestion and reduce fat accumulation in the body.

[0010] Bitter orange fruit: has the effect of digesting and removing stagnation and defecation, helps to reduce body fat, and also helps to improve bloating and indigestion and other problems.

[0011] Poria cocos: It has the effect of invigorating the spleen, promoting water excretion, and purifying the body's metabolism. It helps regulate water balance in the body, reduce edema obesity, and improve spleen deficiency and dampness obesity.

[0012] Dried tangerine or orange peel: It has the effect of regulating qi and reducing phlegm, and helps digestion and reduces fat accumulation in the body. It is used in combination with other ingredients to achieve better weight loss results.

[0013] Peach kernel: It has the effect of promoting blood circulation and removing blood stasis, which helps improve blood circulation and metabolism, thereby helping weight loss.

[0014] Lotus leaf: It has the effect of promoting water excretion, reducing fat, and promoting metabolism, which helps remove excess water and toxins from the body and reduce weight.

[0015] Hawthorn: It has the effect of reducing meat accumulation, dissolving blood clots, and reducing fat, which can promote metabolism and help reduce fat accumulation. It has good effects on high blood lipids and obesity.

[0016] The present application also provides a preparation method of the above-mentioned weight loss and slimming patch, which specifically comprises the following steps:

[0017] X1. According to the raw material formula, white atractylodes rhizome, fructus aurantii, poria cocos, dried tangerine or orange peel, peach kernel, lotus leaf, and hawthorn are weighed and cleaned, dried, and crushed to obtain traditional Chinese medicine powder;

[0018] X2. The above-mentioned traditional Chinese medicine powder is added to water and mixed uniformly, ultrasonically treated, then fermented at a constant temperature with fermentation bacteria, and heated treated. After the end of the process, the filtrate and residue are collected, the filtrate is concentrated to obtain concentrate I;

[0019] X3. The above-mentioned residue is subjected to supercritical extraction, and after the end of the process, the extract is filtered and concentrated to obtain concentrate II;

[0020] X4. The above-mentioned concentrate I, concentrate II, and synergistic adjuvant are mixed uniformly to obtain traditional Chinese medicine active substance;

[0021] X5. The above-mentioned traditional Chinese medicine active substance, sodium alginate, and carboxymethyl cellulose sodium are mixed uniformly with water, then coconut oil is added, and membrane emulsification is carried out. Under stirring conditions, calcium chloride aqueous solution is added dropwise, solidified, and the weight loss and slimming pills are obtained. Then, the pills are adhered to the center of the patch cloth to obtain the weight loss and slimming patch.

[0022] The present application firstly adopts ultrasonic and specific bacteria fermentation treatment to initially extract traditional Chinese medicine raw materials, then adopts supercritical extraction to secondarily extract the residue, thereby maximizing the utilization rate of active substances in traditional Chinese medicine, and through the fermentation treatment of Zooglea aquatilis and plant lactobacillus, not only the cell wall fiber structure of traditional Chinese medicine can be destroyed to help the extraction of intracellular active substances, but also macromolecules can be converted into small molecule active substances that are easier to absorb, thereby further improving the weight loss effect.

[0023] Preferably, in step X2, the fermenting bacteria are Cellulomonas uda and / or Lactobacillus plantarum.

[0024] Preferably, in step X2, the fermenting bacteria are a mixture of Cellulomonas uda and Lactobacillus plantarum in a weight ratio of 1-3:1.

[0025] Preferably, in step X2, the fermenting bacteria are a mixture of Cellulomonas uda and Lactobacillus plantarum in a weight ratio of 1-3:1.

[0026] Preferably, in step X4, the synergistic adjuvant is ginkgetin and / or aloe-emodin.

[0027] Preferably, in step X4, the synergistic adjuvant is a mixture of ginkgetin and aloe-emodin in a weight ratio of 1:1-2.

[0028] Further, the present application also uses the synergistic adjuvant ginkgetin and aloe-emodin. The present application finds that the combination of ginkgetin and aloe-emodin has a synergistic effect through different action pathways and mechanisms, on the one hand reducing the absorption and accumulation of lipids, and on the other hand promoting the decomposition and metabolism of lipids, thereby jointly promoting the enhancement of weight loss effect. Among them, ginkgetin can reduce blood lipids, improve insulin resistance, and promote lipid metabolism, thereby effectively controlling weight gain and inhibiting the accumulation of body fat, and has a direct effect on weight loss; aloe-emodin can inhibit cholesterol absorption, promote intestinal peristalsis, speed up metabolism and promote fat decomposition, effectively reduce cholesterol after entering the body through microcirculation, and inhibit pancreatic enzyme activity, thereby inhibiting the synthesis of body fat and achieving the effect of weight loss and slimming.

[0029] Preferably, the preparation method of the above-mentioned weight loss and slimming patch specifically comprises the following steps:

[0030] X1 weighs 20-40 parts by weight of white atractylodes, 20-40 parts by weight of bitter orange fruit, 10-30 parts by weight of poria cocos, 10-30 parts by weight of dried tangerine or orange peel, 5-15 parts by weight of persicae semen, 10-30 parts by weight of lotus leaf, and 10-30 parts by weight of hawthorn, washes, dries, and grinds to obtain traditional Chinese medicine powder;

[0031] X2 mixes the above-mentioned traditional Chinese medicine powder into water, uniformly mixes, ultrasonically treats, then adds fermenting bacteria for constant temperature fermentation, further adds heat treatment, filters after the end, collects the filtrate and the residue, concentrates the filtrate to obtain concentrate I;

[0032] X3 performs CO2 supercritical extraction on the above-mentioned residue, adds a carrier, filters and concentrates the extract after the end to obtain concentrate II;

[0033] X4: mixing 3-5 parts by weight of the above concentrate I, 5-7 parts by weight of the above concentrate II and 0.1-0.3 parts by weight of a synergistic adjuvant to obtain a Chinese medicinal active substance;

[0034] X5: mixing 1-4 parts by weight of the above Chinese medicinal active substance, 4-6 parts by weight of sodium alginate, 0.3-0.6 parts by weight of sodium carboxymethyl cellulose and 25-30 parts by weight of water, then adding 30-40 parts by weight of coconut oil, performing film emulsification, adding 2-4 parts by weight of calcium chloride aqueous solution dropwise under stirring, solidifying to obtain a weight-reducing pill, and then adhering the pill to the center of a patch to obtain the weight-reducing patch.

[0035] Preferably, in step X1, the crushing is to 100-200 mesh.

[0036] Preferably, in step X2, the solid-liquid ratio of the Chinese medicinal powder to water is 1 g:10-15 mL.

[0037] Preferably, in step X2, the ultrasonic treatment is performed at 100-300 W and 20-40 kHz for 10-30 min.

[0038] Preferably, in step X2, the constant-temperature fermentation is performed at 35-40°C for 30-50 h.

[0039] Preferably, in step X2, the inoculation amount of the fermentation bacteria is 1-5 wt%.

[0040] Preferably, in step X2, the heating treatment is performed at 95-115°C for 10-20 min.

[0041] Preferably, in step X2, the filtrate is concentrated to a relative density of 1.05-1.45 (20°C).

[0042] Preferably, in step X3, the CO2 supercritical extraction is performed at an extraction pressure of 28-35 MPa and a temperature of 40-50°C for 40-60 min.

[0043] Preferably, in step X3, the CO2 flow rate is 30-40 L / h.

[0044] Preferably, in step X3, the entrainer is added in an amount of 15-20 wt% of the residue.

[0045] Preferably, in step X3, the entrainer is an ethanol aqueous solution.

[0046] Preferably, in step X3, the entrainer is an 80-90 wt% ethanol aqueous solution.

[0047] Preferably, in step X3, the extract is concentrated to a relative density of 1.05-1.45 (20℃).

[0048] Preferably, in step X5, the membrane emulsification is performed using a membrane with a pore size of 0.2-0.8 μm.

[0049] Preferably, in step X5, the stirring is performed at 50-100 rpm.

[0050] Preferably, in step X5, the concentration of the calcium chloride aqueous solution is 8-12 wt%.

[0051] Preferably, in step X5, the solidification is performed at room temperature for 30-50 min.

[0052] The present application also provides a method for using the slimming patch as described above, comprising the following steps:

[0053] Clean the skin, take out the slimming pill, and apply it to the navel (Shenque point) half an hour after dinner every night. It can be removed after 12-18 hours. It is convenient to use.

[0054] Precautions:

[0055] Topical use, oral administration is prohibited.

[0056] Before and after applying the gel patch each time, pay attention to cleaning the navel with skin-cleaning water to prevent allergies.

[0057] Pregnant women, lactating women and high-risk groups with severe cardiovascular and cerebrovascular diseases are prohibited.

[0058] The present application has the following advantages:

[0059] (1) The slimming patch provided by the present application uses navel administration, which is convenient to use, and navel administration can reduce the gastrointestinal irritation of the drug.

[0060] (2) The slimming patch provided by the present application uses a preferred traditional Chinese medicine formula and a specific extraction process to obtain a traditional Chinese medicine concentrate, and then combines with a synergistic adjuvant to make a slimming patch with good absorption and treatment effect, stable and long-lasting weight loss effect, and no rebound after stopping use. DETAILED DESCRIPTION

[0061] The technical solutions in the embodiments of the present application will be described below in conjunction with specific embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0062] Example 1

[0063] A weight loss slimming patch is made from the following raw materials by weight:

[0064] 30 parts by weight of Baizhu, 30 parts by weight of Jisheng, 20 parts by weight of Fuling, 20 parts by weight of Chenpi, 10 parts by weight of Taoren, 20 parts by weight of Heye and 20 parts by weight of Shanzha.

[0065] The preparation method of the weight loss slimming patch specifically comprises the following steps:

[0066] X1 Baizhu, Jisheng, Fuling, Chenpi, Taoren, Heye and Shanzha are weighed according to the raw material formula, washed, dried and then pulverized to 150 mesh to obtain traditional Chinese medicine powder;

[0067] X2 The above traditional Chinese medicine powder is added to water in a solid-liquid ratio of 1 g:12 mL and mixed uniformly, ultrasonically treated under the condition of 200 W, 30 kHz for 25 min, then fermented bacteria are added and fermented at 37℃ for 36 h, and then heated at 100℃ for 15 min, after which the filtrate and residue are collected by filtration, the filtrate is concentrated to a relative density of 1.35 (20℃) to obtain concentrate I; wherein the inoculation amount of the fermentation bacteria is 3wt%, and the fermentation bacteria are a mixture of Cellulomonas umida and Lactobacillus plantarum in a weight ratio of 2:1; the number of Cellulomonas umida is CICC 20669, and the number of Lactobacillus plantarum is CICC 20345, both of which are purchased from China Industrial Microbial Culture Collection Center;

[0068] X3 The above residue is subjected to CO2 supercritical extraction under the condition of extraction pressure 30 Mpa and temperature 45℃ for 50 min, and a entrainer is added, after which the extract is filtered and concentrated to a relative density of 1.35 (20℃) to obtain concentrate II; wherein the CO2 flow rate is 35 L / h, and the entrainer is added in an amount of 18wt% of the residue, and the entrainer is 86wt% ethanol aqueous solution;

[0069] X4 The above 4 parts by weight of concentrate I, 6 parts by weight of concentrate II and 0.2 parts by weight of synergistic adjuvant are mixed uniformly to obtain traditional Chinese medicine active substance; the synergistic adjuvant is a mixture of bursin (CAS: 521-32-4) and aloe emodin (CAS: 481-72-1) in a weight ratio of 1:1.5;

[0070] X5 The above 2.5 parts by weight of traditional Chinese medicine active substance, 5 parts by weight of sodium alginate, 0.5 parts by weight of sodium carboxymethyl cellulose and 27 parts by weight of water are mixed uniformly, then 35 parts by weight of coconut oil is added, membrane emulsification is carried out using a membrane with a pore size of 0.5 μm, 3 parts by weight of 10wt% calcium chloride aqueous solution is added dropwise under the condition of stirring at 80 rpm, and solidification is carried out at room temperature for 40 min to obtain weight loss slimming pills, which are then adhered to the center of the patch cloth to obtain the weight loss slimming patch.

[0071] Example 2

[0072] A weight loss and slimming patch is made from the following raw materials by weight:

[0073] 20 parts by weight of white atractylodes, 20 parts by weight of bitter orange fruit, 10 parts by weight of poria, 10 parts by weight of dried tangerine or orange peel, 5 parts by weight of peach kernel, 10 parts by weight of lotus leaf, and 10 parts by weight of hawthorn.

[0074] The preparation method of the weight loss and slimming patch is the same as that of Example 1.

[0075] Example 3

[0076] A weight loss and slimming patch is made from the following raw materials by weight:

[0077] 40 parts by weight of white atractylodes, 40 parts by weight of bitter orange fruit, 30 parts by weight of poria, 30 parts by weight of dried tangerine or orange peel, 15 parts by weight of peach kernel, 30 parts by weight of lotus leaf, and 30 parts by weight of hawthorn.

[0078] The preparation method of the weight loss and slimming patch is the same as that of Example 1.

[0079] Example 4

[0080] A weight loss and slimming patch is made from the following raw materials by weight:

[0081] 30 parts by weight of white atractylodes, 30 parts by weight of bitter orange fruit, 20 parts by weight of poria, 20 parts by weight of dried tangerine or orange peel, 10 parts by weight of peach kernel, 20 parts by weight of lotus leaf, and 20 parts by weight of hawthorn.

[0082] The preparation method of the weight loss and slimming patch specifically includes the following steps:

[0083] X1 takes white atractylodes, bitter orange fruit, poria, dried tangerine or orange peel, peach kernel, lotus leaf, and hawthorn according to the raw material formula, washes, dries, and grinds to 150 mesh to obtain traditional Chinese medicine powder;

[0084] X2 adds the above traditional Chinese medicine powder to water according to a solid-liquid ratio of 1 g:12 mL, mixes uniformly, ultrasonically treats for 25 min under the condition of 200 W, 30 kHz, then adds fermentation bacteria, and ferments at a constant temperature of 37℃ for 36 h, and then heats at 100℃ for 15 min, filters after the end, collects the filtrate, concentrates the filtrate to a relative density of 1.35 (20℃) to obtain a concentrate; wherein the inoculation amount of the fermentation bacteria is 3wt%, and the fermentation bacteria is a mixture of Cellulomonas pachnogena and Lactobacillus plantarum in a weight ratio of 2:1; the number of Cellulomonas pachnogena is CICC 20669, and the number of Lactobacillus plantarum is CICC 20345, both of which are purchased from the China Industrial Microbial Culture Collection Center;

[0085] X3mix 10 parts by weight of the concentrate with 0.2 parts by weight of a synergistic adjuvant to obtain the active ingredient of traditional Chinese medicine; the synergistic adjuvant is a mixture of ginkgetin (CAS: 521-32-4) and aloe-emodin (CAS: 481-72-1) in a weight ratio of 1:1.5;

[0086] X4mix 2.5 parts by weight of the active ingredient of traditional Chinese medicine, 5 parts by weight of sodium alginate, 0.5 parts by weight of sodium carboxymethyl cellulose with 27 parts by weight of water, then add 35 parts by weight of coconut oil, use a membrane with a pore size of 0.5 μm for membrane emulsification, under the condition of stirring at 80 rpm, add 3 parts by weight of 10 wt% calcium chloride aqueous solution dropwise, and solidify at room temperature for 40 min to obtain weight loss pills, then adhere to the center of the patch, and the weight loss patch is obtained.

[0087] Example 5

[0088] A weight loss patch is made from the following parts by weight of raw materials:

[0089] 30 parts by weight of Baizhu, 30 parts by weight of Shiju, 20 parts by weight of Fuling, 20 parts by weight of Chenpi, 10 parts by weight of Taoren, 20 parts by weight of Heye and 20 parts by weight of Shanzha.

[0090] A method for preparing a weight loss patch, specifically comprising the following steps:

[0091] X1take Baizhu, Shiju, Fuling, Chenpi, Taoren, Heye and Shanzha according to the raw material formula, wash, dry and then crush to 150 mesh to obtain traditional Chinese medicine powder;

[0092] X2place the traditional Chinese medicine powder in the above-mentioned CO2 supercritical extraction under the conditions of extraction pressure 30 Mpa and temperature 45℃ for 50 min, and add an entrainer; after the end, filter and concentrate the extract to a relative density of 1.35 (20℃) to obtain a concentrate; wherein the CO2 flow rate is 35 L / h, the amount of entrainer added is 18 wt% of the traditional Chinese medicine powder, and the entrainer is 86 wt% ethanol aqueous solution;

[0093] X3mix 10 parts by weight of the concentrate with 0.2 parts by weight of a synergistic adjuvant to obtain the active ingredient of traditional Chinese medicine; the synergistic adjuvant is a mixture of ginkgetin (CAS: 521-32-4) and aloe-emodin (CAS: 481-72-1) in a weight ratio of 1:1.5;

[0094] X4 mixes 2.5 parts by weight of the active ingredient of traditional Chinese medicine, 5 parts by weight of sodium alginate, 0.5 parts by weight of sodium carboxymethyl cellulose and 27 parts by weight of water evenly, then adds 35 parts by weight of coconut oil, emulsifies the mixture using a membrane with a pore size of 0.5 μm, and adds 3 parts by weight of 10 wt% calcium chloride aqueous solution dropwise under stirring at 80 rpm. The mixture is then cured at room temperature for 40 min to obtain a slimming pill, which is then adhered to the center of a patch to obtain the slimming patch.

[0095] Example 6

[0096] A slimming patch is made from the following ingredients in parts by weight:

[0097] 30 parts by weight of Atractylodes macrocephala, 30 parts by weight of Citrus aurantium, 20 parts by weight of Poria cocos, 20 parts by weight of Citrus reticulata peel, 10 parts by weight of Prunus persica, 20 parts by weight of Nelumbo nucifera leaf and 20 parts by weight of Crataegus pinnatifida.

[0098] A method for preparing a slimming patch, specifically including the following steps:

[0099] X1 Weigh out Atractylodes macrocephala, Citrus aurantium, Poria cocos, Citrus reticulata peel, Prunus persica kernel, Nelumbo nucifera leaf and Crataegus pinnatifida according to the raw material formula, wash and dry them, and then pulverize them to 150 mesh to obtain Chinese medicine powder.

[0100] X2 The above-mentioned Chinese herbal medicine powder was added to water at a solid-liquid ratio of 1g:12mL and mixed evenly. The mixture was ultrasonically treated at 200W and 30kHz for 25min. Then, fermentation bacteria were added and fermented at 37℃ for 36h. After that, it was heated at 100℃ for 15min. After the treatment, the mixture was filtered, and the filtrate and residue were collected. The filtrate was concentrated to a relative density of 1.35 (20℃) to obtain concentrate I. The inoculum amount of fermentation bacteria was 3wt%, and the fermentation bacteria was a mixture of *Cyclomonella hygroscopica* and *Lactobacillus plantarum* at a weight ratio of 2:1. *Cyclomonella hygroscopica* was designated CICC 20669, and *Lactobacillus plantarum* was designated CICC20345. Both were purchased from the China Industrial Microbial Culture Collection Center.

[0101] X3 The above filter residue was subjected to supercritical CO2 extraction at an extraction pressure of 30 MPa and a temperature of 45 °C for 50 min, and an entrainer was added. After the extraction was completed, the extract was filtered and concentrated to a relative density of 1.35 (20 °C) to obtain concentrate II. The CO2 fluid flow rate was 35 L / h, the amount of entrainer added was 18 wt% of the filter residue, and the entrainer was an 86 wt% aqueous ethanol solution.

[0102] X4 mixes 4 parts by weight of concentrate I and 6 parts by weight of concentrate II with 0.2 parts by weight of synergistic adjuvant to obtain the active ingredient of traditional Chinese medicine; the synergistic adjuvant is ginkgo flavonoid (CAS: 521-32-4);

[0103] X5 mix 2.5 parts by weight of the traditional Chinese medicine active, 5 parts by weight of sodium alginate, 0.5 parts by weight of sodium carboxymethyl cellulose and 27 parts by weight of water, then add 35 parts by weight of coconut oil, use a membrane with a pore size of 0.5 μm for membrane emulsification, under the condition of stirring at 80 rpm, add 3 parts by weight of 10 wt% calcium chloride aqueous solution dropwise, solidify at room temperature for 40 min, obtain the weight-reducing and slimming pills, then adhere to the center of the patch, and the weight-reducing and slimming patch is obtained.

[0104] Example 7

[0105] A weight-reducing and slimming patch is made from the following parts by weight of raw materials:

[0106] 30 parts by weight of Baizhu, 30 parts by weight of Jisheng, 20 parts by weight of Fuling, 20 parts by weight of Chenpi, 10 parts by weight of Taoren, 20 parts by weight of Heye and 20 parts by weight of Shanzha.

[0107] A preparation method of a weight-reducing and slimming patch, specifically comprising the following steps:

[0108] X1 weigh Baizhu, Jisheng, Fuling, Chenpi, Taoren, Heye and Shanzha according to the raw material formula, wash, dry and then crush to 150 mesh to obtain traditional Chinese medicine powder;

[0109] X2 mix the above traditional Chinese medicine powder in water at a solid-liquid ratio of 1 g:12 mL, uniformly, ultrasonically treat under the condition of 200 W and 30 kHz for 25 min, then add fermentation bacteria, and ferment at 37℃ for 36 h, and then heat treat at 100℃ for 15 min, after the end of the treatment, filter, collect the filtrate and the residue, concentrate the filtrate to a relative density of 1.35 (20℃) to obtain concentrate I; wherein the inoculation amount of the fermentation bacteria is 3 wt%, and the fermentation bacteria is a mixture of Cellulomonas umida and Lactobacillus plantarum at a weight ratio of 2:1; the number of Cellulomonas umida is CICC 20669, and the number of Lactobacillus plantarum is CICC 20345, both of which are purchased from China Industrial Microbial Culture Collection Center;

[0110] X3 perform CO2 supercritical extraction on the above residue under the condition of an extraction pressure of 30 Mpa and a temperature of 45℃ for 50 min, and add an entrainer, after the end of the extraction, filter the extract, and concentrate to a relative density of 1.35 (20℃) to obtain concentrate II; wherein the flow rate of CO2 fluid is 35 L / h, and the addition amount of the entrainer is 18 wt% of the residue, and the entrainer is 86 wt% ethanol aqueous solution;

[0111] X4 mix 4 parts by weight of concentrate I, 6 parts by weight of concentrate II and 0.2 parts by weight of synergistic adjuvant uniformly to obtain traditional Chinese medicine active; the synergistic adjuvant is aloe-emodin (CAS: 481-72-1);

[0112] X5: 2.5 parts by weight of the Chinese medicinal active ingredient, 5 parts by weight of sodium alginate, 0.5 parts by weight of sodium carboxymethyl cellulose, 27 parts by weight of water, 35 parts by weight of coconut oil, 3 parts by weight of 10 wt% calcium chloride aqueous solution, and 0.5 parts by weight of 10 wt% calcium chloride aqueous solution.

[0113] Test Example 1

[0114] SPF level SD male rats (weight 200-220 g) were randomly divided into 9 groups, 10 rats in each group. Among them, the blank control group was given ordinary feed; the high-fat control group was given high-fat feed (fat energy supply ratio 60%); the groups of Examples 1-7 were given high-fat feed (fat energy supply ratio 60%), and one dose of the slimming patch of Examples 1-7 was pasted on the navel every day, and was replaced every day. During the feeding period, the rats were allowed to eat and drink freely, and were continuously fed for 40 days. The body weight of the rats at the beginning and end of the test was determined, and the weight gain rate was calculated. The results are shown in Table 1. The formula is as follows: weight gain rate = (end weight - initial weight) / initial weight x 100%.

[0115] Table 1. Effect of slimming patch on body weight of rats

[0116]

[0117]

[0118] Test Example 2

[0119] The test method was the same as that of Test Example 1. After the end of the test, the total cholesterol TC and triglyceride TG contents in the serum of the rats were determined, and the results are shown in Table 2.

[0120] Table 2. Effect of slimming patch on TC and TG contents in serum of rats

[0121] TC / mM TG / mM High fat control 3.91 1.13 Example 1 2.20 0.45 Example 4 2.78 0.76 Example 5 2.52 0.64 Example 6 2.35 0.54 Example 7 2.43 0.60

[0122] It can be seen that the weight control effect of the slimming and weight-reducing patch prepared in embodiments 1-3 is the best. The reason is that, compared with embodiments 4-5, embodiments 1-3 first use ultrasonic and specific bacteria fermentation treatment to extract the traditional Chinese medicine raw materials in the preparation process, and then use supercritical extraction to extract the filter residue for the second time, which maximizes the utilization rate of the active substances in traditional Chinese medicine. Through the fermentation treatment of Cellulomonas uda and Bacillus plantarum, not only the cell wall fiber structure of traditional Chinese medicine can be destroyed, which is helpful for the extraction of intracellular active substances, but also macromolecules can be converted into small molecule active substances that are easier to absorb, thereby further improving the weight loss effect. Compared with embodiments 6-7, embodiments 1-3 use synergistic adjuvant ginkgetin and aloe emodin in the preparation process. Through different action pathways and mechanisms, the two complement each other, on the one hand reducing the absorption and accumulation of lipids, and on the other hand promoting the decomposition and metabolism of lipids, thereby jointly promoting the weight loss effect. Among them, ginkgetin can reduce blood lipids, improve insulin resistance, and promote lipid metabolism, thereby effectively controlling weight gain and inhibiting the accumulation of fat in the body, and has a direct effect on weight loss; aloe emodin can inhibit cholesterol absorption, promote intestinal peristalsis, speed up metabolism and promote fat decomposition, effectively reduce cholesterol after entering the body through microcirculation, and inhibit pancreatic enzyme activity, thereby inhibiting the synthesis of fat in the body, and play a role in weight loss and weight reduction.

[0123] The preferred embodiments of the present application are described in detail above. It should be understood that those skilled in the art can make many modifications and changes without creative labor based on the concept of the present application. Therefore, any technical solution obtained by logical analysis, reasoning or limited experiment based on the prior art according to the concept of the present application shall be within the protection scope determined by the claims.

Claims

1. A slimming patch, characterized in that, It is prepared from the following raw materials: Baizhu, Shijian, Fuling, Chenpi, Taoren, Heye and Shanzha.

2. The slimming patch of claim 1, wherein the active ingredient is selected from the group consisting of caffeine, theophylline, theobromine, and a combination thereof. It is prepared from the following raw materials: 20-40 parts by weight of Baizhu, 20-40 parts by weight of Shijian, 10-30 parts by weight of Fuling, 10-30 parts by weight of Chenpi, 5-15 parts by weight of Taoren, 10-30 parts by weight of Heye and 10-30 parts by weight of Shanzha.

3. The preparation method of the slimming patch according to claim 1 or 2, characterized in that, It comprises the following steps: X1: Baizhu, Shijian, Fuling, Chenpi, Taoren, Heye and Shanzha are weighed according to the raw material formula, washed, dried and then pulverized to obtain Chinese medicinal powder; X2: the Chinese medicinal powder is added into water and mixed uniformly, then treated by ultrasonic, and then fermented by fermentation bacteria, and then treated by heating, and then filtered to collect filtrate and residue, and then the filtrate is concentrated to obtain concentrate I; X3: the residue is treated by supercritical extraction, and then the extract is filtered and concentrated to obtain concentrate II; X4: the concentrate I, the concentrate II and a synergistic aid are mixed uniformly to obtain Chinese medicinal active substance; X5: the Chinese medicinal active substance, sodium alginate, sodium carboxymethyl cellulose and water are mixed uniformly, and then coconut oil is added to perform membrane emulsification, and then calcium chloride aqueous solution is added dropwise under stirring to solidify, and then the slimming pills are obtained, and then the slimming pills are adhered to the center of the patch to obtain the slimming patch.

4. The method of claim 3, wherein the slimming patch is prepared by mixing the active ingredient, the base material, and the adhesive material. It comprises the following steps: X1: 20-40 parts by weight of Baizhu, 20-40 parts by weight of Shijian, 10-30 parts by weight of Fuling, 10-30 parts by weight of Chenpi, 5-15 parts by weight of Taoren, 10-30 parts by weight of Heye and 10-30 parts by weight of Shanzha are weighed, washed, dried and then pulverized to obtain Chinese medicinal powder; X2: the Chinese medicinal powder is added into water and mixed uniformly, then treated by ultrasonic, and then fermented by fermentation bacteria at constant temperature, and then treated by heating, and then filtered to collect filtrate and residue, and then the filtrate is concentrated to obtain concentrate I; X3: the residue is treated by CO2 supercritical extraction, and then a entrainer is added, and then the extract is filtered and concentrated to obtain concentrate II; X4: 3-5 parts by weight of the concentrate I, 5-7 parts by weight of the concentrate II and 0.1-0.3 parts by weight of a synergistic aid are mixed uniformly to obtain Chinese medicinal active substance; X5: 1-4 parts by weight of the Chinese medicinal active substance, 4-6 parts by weight of sodium alginate, 0.3-0.6 parts by weight of sodium carboxymethyl cellulose and 25-30 parts by weight of water are mixed uniformly, and then 30-40 parts by weight of coconut oil is added to perform membrane emulsification, and then 2-4 parts by weight of calcium chloride aqueous solution is added dropwise under stirring to solidify, and then the slimming pills are obtained, and then the slimming pills are adhered to the center of the patch to obtain the slimming patch.

5. The preparation method of the slimming patch according to claim 3 or 4, characterized in that, The fermentation bacteria in step X2 are a mixture of Cellulomonas pannesa and Lactobacillus plantarum.

6. The preparation method of the slimming patch according to claim 3 or 4, characterized in that, The synergistic aid in step X4 is bilobalavone and / or aloe-emodin.

7. The preparation method of the weight-loss slimming patch according to claim 3 or 4, characterized in that, The entrainer in step X3 is ethanol aqueous solution.

8. The preparation method of the weight-loss slimming patch according to claim 3 or 4, characterized in that, The solid-liquid ratio of the Chinese medicinal powder to water in step X2 is 1g:10-15mL.

9. The preparation method of the weight-loss slimming patch according to claim 3 or 4, characterized in that, The inoculation amount of the fermentation bacteria in step X2 is 1-5wt%.

10. The preparation method of the slimming patch according to claim 3 or 4, characterized in that, In steps X2 and X3, the concentration is to relative density 1.05-1.45.

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