Cross pipeline online sterilization system of plastic ampoule liquid filling system
Through the online sterilization system, the cross-pipes in the plastic ampoule filling system are independently sterilized, and the problems of pollution risk and low production efficiency in the sterilization process in the prior art are solved, and the blowing is achieved Effective sterilization of the infusion pipeline of the potting system and continuous operation of the liquid dispensing system.
Patent Information
- Application Number
- CN202323262134.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2023-12-01
- Publication Date
- 2024-12-06
- Estimated Expiration
- 2033-12-01
AI Technical Summary
In the existing plastic ampoule filling system, the sterilization process of cross-pipes has problems of contamination risks and low production efficiency, especially the infusion pipelines of the blow-pouring system are difficult to achieve independent sterilization, which affects the continuous operation of the liquid dispensing process.
An online sterilization system was designed, which connects the drug liquid pipeline, return pipeline, infusion pipeline and sterilization pipeline through four-way connectors, and uses pure steam to sterilize the cross-pipes to ensure that the infusion pipeline of the blow-pouring system can be independently extinguished. sterilization avoids contamination of liquid distribution system and optimizes the sterilization process through temperature monitoring and drain valves.
The cross-pipe is fully sterilized, production efficiency is improved, and the continuity of the plastic ampoule filling process and product quality are ensured.
Smart Images
Figure CN222110531U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the field of automated production of plastic ampoules, in particular to a cross-pipeline online sterilization system connecting a liquid preparation system and a blowing, filling and sealing system in a plastic ampoule filling system. Background Art
[0002] Plastic ampoules are injection preparations made from plastic particles through the blow-fill-seal (BFS) three-in-one aseptic filling technology. In order to achieve the full automation of the liquid preparation and BFS production of the plastic ampoule filling system, the liquid preparation system and the BFS system are usually connected by a three-way joint. Figure 1 This is a schematic diagram of the cross-pipe connection between the liquid preparation system and the blow-fill-seal system in the filling system.
[0003] See also Figure 1 , the liquid preparation system I pipeline and the blowing, filling and sealing system II pipeline are sterilized separately. When the liquid preparation system I pipeline is sterilized with pure steam, valves d and e are in the open state, valve i is in the closed state, and the pure steam introduced into the temporary storage tank a passes through the liquid pipeline b through the intersection and then flows into the temporary storage tank through the reflux pipeline c, completing the sterilization of the liquid preparation system I. Since there is a dead angle in the infusion pipeline g at the front end of the balance tank f of the BFS system II, it is difficult to sterilize the infusion pipeline g without the help of the pipeline of the liquid preparation system I. When sterilizing the infusion pipeline g, valves i and e are in the open state, and valve d is in the closed state. Pure steam needs to be introduced into the balance tank f, and the pure steam flows into the temporary storage tank a through the return pipe c of the liquid preparation system I to complete the sterilization of the BFS system II. At this time, the pure steam enters the sterilized temporary storage tank a, which has the risk of contaminating the sterilized liquid preparation system I, and also affects the next step of the liquid preparation process, that is, when the pure steam sterilization of the temporary storage tank a of the liquid preparation system I is not completed, the next step of the liquid preparation operation cannot be carried out, which seriously affects the production efficiency. The liquid in the balance tank f is filled into plastic ampoules. Utility Model Content
[0004] In view of the problems existing in the prior art, the purpose of the utility model is to provide an online sterilization system (SIP) for the cross pipes of the liquid preparation system and the blow-fill-seal system in the plastic ampoule filling system, so as to fully sterilize the cross pipes during the filling production process of the plastic ampoule without affecting the production efficiency of the plastic ampoule.
[0005] To achieve the above purpose, the technical solution of the utility model is as follows:
[0006] A cross-pipe online sterilization system for a plastic ampoule filling system, comprising: a liquid preparation system, a blow-fill-seal system, and a sterilization pipeline;
[0007] The liquid preparation system includes a temporary storage tank, a liquid medicine pipeline and a return pipeline; the blow-fill-seal system includes a liquid infusion pipeline and a balance tank;
[0008] One end of the medicine liquid pipeline, one end of the return pipeline, one end of the infusion pipeline and one end of the sterilization pipeline are connected through a four-way joint, and a medicine liquid valve, a return valve, an infusion valve and a sterilization valve are respectively installed on the medicine liquid pipeline, the return pipeline, the infusion pipeline and the sterilization pipeline connected to the four-way joint;
[0009] The other end of the medicine liquid pipeline and the other end of the reflux pipeline are respectively connected to the lower end and the upper end of the temporary storage tank; the other end of the infusion pipeline is connected to the lower end of the balance tank.
[0010] Furthermore, a temperature monitoring probe is installed on the sterilization pipeline.
[0011] Furthermore, a steam trap is installed on the sterilization pipeline.
[0012] Furthermore, the blow-fill-seal system further includes a sewage discharge pipe, and the other end of the sterilization pipe is connected to the sewage discharge pipe.
[0013] Furthermore, the blow-fill-seal system further comprises a filling pipe, one end of which is connected to the lower end of the balancing tank.
[0014] The utility model discloses an online sterilization system for the cross-pipe of the liquid filling system of the plastic ampoule. The cross-pipes of the liquid preparation system and the blowing, filling and sealing system can be sterilized by the sterilization pipe. When the pipe of the liquid preparation system is sterilized by pure steam, the pure steam flows out from the medicine liquid pipe of the temporary storage tank, flows into the temporary storage tank from the reflux pipe after passing through the four-way joint, and flows out of the liquid preparation system from the sterilization pipe, so as to complete the sterilization of the pipe of the liquid preparation system; when the pipe of the blowing, filling and sealing system is sterilized by pure steam, the pure steam flows out from the infusion pipe of the balancing tank, flows into the temporary storage tank from the sterilization pipe after passing through the four-way joint, and flows out of the blowing, filling and sealing system from the sterilization pipe, so as to complete the sterilization of the pipe of the blowing, filling and sealing system, and realizes the sterilization of the entire infusion pipe between the balancing tank and the four-way joint. Moreover, the sterilization of the infusion pipe does not require the help of the pipe of the liquid preparation system, and will not pollute the liquid preparation system. When the infusion pipe is sterilized online, it will not affect the liquid preparation process, so as to ensure the production efficiency of the plastic ampoule. BRIEF DESCRIPTION OF THE DRAWINGS
[0015] Figure 1 It is a schematic diagram of the cross-pipe of the plastic ampoule filling system in the background technology;
[0016] Figure 2 A schematic diagram of a cross-pipeline online sterilization system for a plastic ampoule filling system provided in an embodiment of the utility model;
[0017] In the figure:
[0018] 100—liquid dispensing system; 101—temporary storage tank; 102—liquid medicine pipeline; 103—return pipeline; 104—liquid medicine valve; 105—return valve;
[0019] 200—BFSC system; 201—Balance tank; 202—Infusion pipeline; 203—Filling pipeline; 204—Infusion valve;
[0020] 300—Sterilization pipeline; 301—Sterilization valve; 302—Temperature monitoring probe; 303—Steam trap. DETAILED DESCRIPTION
[0021] In order to enable those skilled in the art to better understand the solution of the utility model, the technical solution of the utility model is clearly and completely described below in conjunction with the drawings in the examples of the utility model. Obviously, the described examples are only part of the examples of the utility model, not all of the examples. Based on the examples in the utility model, all other implementation methods obtained by ordinary technicians in the field without making creative work should fall within the scope of protection of the utility model. Example
[0022] like Figure 2 As shown, this embodiment provides a cross-pipe online sterilization system of a plastic ampoule filling system of the utility model, comprising: a liquid preparation system 100, a blow-fill-seal system 200, and a sterilization pipeline 300;
[0023] The liquid preparation system includes a temporary storage tank 101, a liquid medicine pipeline 102 and a return pipeline 103; the blow-fill-seal system 200 includes a liquid delivery pipeline 202 and a balance tank 201;
[0024] One end of the liquid medicine pipeline 102, one end of the return pipeline 103, one end of the infusion pipeline 202 and one end of the sterilization pipeline 300 are connected through a four-way joint, and a liquid medicine valve 104, a return valve 105, an infusion valve 204 and a sterilization valve 301 are installed on the liquid medicine pipeline 102, the return pipeline 103, the infusion pipeline 202 and the sterilization pipeline 300 connected to the four-way joint respectively;
[0025] The other end of the drug liquid pipeline 102 and the other end of the return pipeline 103 are respectively connected to the lower end and the upper end of the temporary storage tank 101; the other end of the infusion pipeline 202 is connected to the lower end of the balance tank 201.
[0026] In the cross-pipe online sterilization system of the plastic ampoule filling system of the present embodiment, the cross-pipes of the liquid preparation system 100 and the blow-fill-seal system 200 can be sterilized by using the sterilization pipe 300. When the pipes of the liquid preparation system are sterilized by pure steam, the liquid valve 104, the reflux valve 105 and the sterilization valve 301 are opened, and the infusion valve 204 is closed. Pure steam flows out from the liquid pipe 102 of the temporary storage tank 101, flows into the temporary storage tank 101 from the reflux pipe 103 after passing through the four-way joint, and flows out of the liquid preparation system 100 from the sterilization pipe 300, thereby completing the sterilization of the pipes of the liquid preparation system 100. When the pipes of the blow-fill-seal system 200 are sterilized by pure steam, the liquid infusion valve 204 is opened, and the liquid infusion valve 204 is closed. Pure steam flows out from the liquid pipe 102 of the temporary storage tank 101, flows into the temporary storage tank 101 from the reflux pipe 103 after passing through the four-way joint, and flows out of the liquid preparation system 100 from the sterilization pipe 300, thereby completing the sterilization of the pipes of the liquid preparation system 100. The valve 204 and the sterilization valve 301 are opened, the liquid medicine valve 104 and the reflux valve 105 are closed, and pure steam flows out of the infusion pipeline 202 of the balancing tank 201, and flows out of the BFS system 200 from the sterilization pipeline 300 after passing through the four-way joint, thereby completing the sterilization of the pipeline of the BFS system 200, and realizing the sterilization of the entire infusion pipeline 202 between the balancing tank 201 and the four-way joint. The sterilization of the infusion pipeline 202 does not require the help of the pipeline of the liquid preparation system 100, and will not pollute the liquid preparation system 100. When the infusion pipeline 202 is sterilized online, it will not affect the liquid preparation process, thereby ensuring the production efficiency of the liquid preparation and thus ensuring the production efficiency of the plastic ampoules.
[0027] It should be noted that the pipeline of the liquid preparation system 100 can also adopt the sterilization method of the original liquid filling system. During sterilization, the medicine liquid valve 104 and the return valve 105 are opened, the infusion valve 204 and the sterilization valve 301 are closed, and pure steam flows out from the medicine liquid pipeline 102 of the temporary storage tank 101, passes through the four-way joint, and flows into the temporary storage tank 101 from the return pipeline 103, thereby completing the sterilization of the pipeline of the liquid preparation system 100.
[0028] A temperature monitoring probe 302 is also installed on the sterilization pipeline 300 of this embodiment to monitor the temperature of the steam used for sterilization. Temperature feedback is provided through the temperature monitoring probe 302 to adjust the amount of steam in the online sterilization system to ensure that the steam can effectively sterilize the pipelines of the liquid preparation system 100 and the blow-fill-seal system 200.
[0029] In this embodiment, a steam trap 303 is also installed on the sterilization pipeline 300 , and the steam trap 303 automatically discharges condensed water in the sterilization pipeline 300 .
[0030] The blow-fill-seal system of this embodiment also includes a sewage pipe (not shown in the figure), and the other end of the sterilization pipe 300 is connected to the sewage pipe. The condensed water is discharged into the sewage pipe through the drainage effect of the steam trap 303, so as to be discharged from the blow-fill-seal system together with the sewage pipe.
[0031] The blow-fill-seal system of this embodiment further comprises a filling pipe 203, one end of which is connected to the lower end of the balancing tank. The filling pipe 203 is used for filling the Chinese medicine liquid in the plastic ampoule.
[0032] Finally, it is understood that the above embodiments are merely exemplary embodiments used to illustrate the principles of the present invention, but the present invention is not limited thereto. For those skilled in the art, various modifications and improvements can be made without departing from the principles and essence of the present invention, and these modifications and improvements are also considered to be within the scope of protection of the present invention.
Claims
1. A cross-pipe online sterilization system for a plastic ampoule filling system, characterized in that: include: Liquid preparation system, BFS system, sterilization pipeline; The liquid preparation system includes a temporary storage tank, a liquid medicine pipeline and a return pipeline; the blow-fill-seal system includes a liquid infusion pipeline and a balance tank; One end of the medicine liquid pipeline, one end of the return pipeline, one end of the infusion pipeline and one end of the sterilization pipeline are connected through a four-way joint, and a medicine liquid valve, a return valve, an infusion valve and a sterilization valve are respectively installed on the medicine liquid pipeline, the return pipeline, the infusion pipeline and the sterilization pipeline connected to the four-way joint; The other end of the medicine liquid pipeline and the other end of the reflux pipeline are respectively connected to the lower end and the upper end of the temporary storage tank; the other end of the infusion pipeline is connected to the lower end of the balance tank.
2. The cross-pipeline online sterilization system according to claim 1 is characterized in that: A temperature monitoring probe is also installed on the sterilization pipeline.
3. The cross-pipeline online sterilization system according to claim 1 or 2, characterized in that: A steam trap is also installed on the sterilization pipeline.
4. The cross-pipeline online sterilization system according to claim 3 is characterized in that: The blow-fill-seal system further comprises a sewage discharge pipe, and the other end of the sterilization pipe is connected to the sewage discharge pipe.
5. The cross-pipeline online sterilization system according to claim 1 is characterized in that: It also includes a filling pipe, one end of which is connected to the lower end of the balancing tank.