High-purity heparin sodium fine filtration mechanism

Abstract

The utility model discloses a fine filtration mechanism for high-purity heparin sodium, which belongs to the technical field of heparin sodium filtration and purification, and comprises a filter box, a collection box is arranged in the filter box, the left side surface and the right side surface of the filter box are respectively provided with a dismounting port, and the front surface and the back surface of the filter box are respectively and fixedly connected with a connecting block. A hydraulic rod is fixedly connected to the upper surface of each connecting block, the telescopic ends of the two hydraulic rods are jointly and fixedly connected with a connecting frame, a guide column is fixedly connected to the bottom surface of the connecting frame, and a filtering frame is slidably connected to the interior of the filtering box. According to the fine filtration mechanism for the high-purity heparin sodium, when the microporous filtration plates move downwards, a heparin sodium solution is forced to enter the upper part of the filtration frame through filtration of the two microporous filtration plates, and impurities in the heparin sodium are blocked by the microporous filtration plates, so that when the heparin sodium is subjected to high-purity fine filtration, the impurities in the heparin sodium are prevented from entering the filtration frame; the heparin sodium solution does not need to be filtered and purified in a precipitation mode, and the filtering and purifying efficiency of the heparin sodium solution is effectively improved.

Description

Technical Field

[0001] The present application belongs to the technical field of sodium heparin filtration and purification, and in particular relates to a high-purity sodium heparin fine filtration mechanism. Background Art

[0002] Heparin sodium can interfere with many links of the blood coagulation process and has anticoagulant effects both in vivo and in vitro. Its mechanism of action is relatively complex. It mainly binds to antithrombin III (AT-III) to enhance the latter's inhibitory effect on activated II, IX, X, XI and XII coagulation factors. The consequences involve preventing platelet aggregation and destruction, hindering the formation of coagulation activating enzymes, preventing prothrombin from turning into thrombin, inhibiting thrombin, and thus hindering fibrinogen from turning into fibrin, thereby exerting an anticoagulant effect. In order to increase the purity of heparin sodium, a sedimentation and filtration mechanism is usually used to remove impurities inside the heparin sodium.

[0003] The utility model with the existing authorization announcement number CN206778013U discloses a sodium heparin precipitation and filtration tank, including a precipitation tank and a supernatant recovery tank, wherein the precipitation tank and the supernatant recovery tank are connected by a pump, and the precipitation tank includes a closed cylindrical tank body and a stirring mechanism and a supernatant extraction mechanism arranged on the closed cylindrical tank body, a heating jacket and an observation hole are arranged on the outside of the cylinder wall of the closed cylindrical tank body, and a hot water pipe is opened inside the heating jacket.

[0004] By adopting the above technical solution, the supernatant after precipitation can be directly pumped into the supernatant recovery tank for recycling. At the same time, the filter screen is designed to be two semicircular screens that can be automatically opened and closed by a telescopic push rod. On the one hand, the filter residue can be initially filtered while precipitation is in progress. On the other hand, after precipitation is completed, the two semicircular screens can be driven by the telescopic push rod to close the two semicircular screens, thereby realizing automatic unloading. However, the above technical solution only uses precipitation to filter and remove impurities from the crude sodium heparin solution when fine filtering and purification is performed on the sodium heparin solution, which greatly increases the filtering and purification time of the sodium heparin solution and affects the efficiency of fine filtering and purification of the sodium heparin solution.

[0005] Therefore, we propose a high-purity heparin sodium fine filtration mechanism to solve the above problems. Utility Model Content

[0006] The purpose of the present application is to solve the problem in the prior art that the fine filtration precipitation filtration time of heparin sodium solution is long, which affects the purification efficiency of heparin sodium solution, and to propose a high-purity heparin sodium fine filtration mechanism.

[0007] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0008] The filter press has two ends, and the ends are fixedly connected to the filter press, and the ends are closed by the filter press, and the filter press has two ends, and the filter press has two ends.

[0009] Preferably, a mounting plate is fixedly connected to the bottom surface of the filter box, and four mounting holes are formed on the upper surface of the mounting plate.

[0010] Preferably, a sealing plate is fixedly connected to the left side of the collecting box, the right side of the sealing plate contacts the left side of the filter box, the left side of the sealing plate is fixedly connected to a handle, and the outer surface of the handle is fixedly connected to an anti-slip sleeve.

[0011] Preferably, two locking blocks are fixedly connected to the front and back sides of the sealing plate, and two locking frames are fixedly connected to the front and back sides of the filter box, and each of the locking blocks is clamped inside the locking frame.

[0012] Preferably, the left side surface of the filter box is fixedly connected with a liquid adding pipe, and the top end of the liquid adding pipe is clamped with a dust plug.

[0013] Preferably, a sealing ring is fixedly connected to the bottom surface of the filter frame, and the outer surface of the sealing ring is in contact with the inner wall of the filter box.

[0014] Preferably, a reinforcement sleeve is fixedly connected to the upper surface of the lower pressure frame, and the inner wall of the reinforcement sleeve is fixedly connected to the outer surface of the guide column.

[0015] Preferably, a fixing flange is fixedly connected to the outer surface of the water outlet end of the water suction pump, and the right side of the fixing flange is provided with fixing through holes arranged at equal distances.

[0016] In summary, the technical effects and advantages of this application are:

[0017] By providing the power provided by the hydraulic rod and the connection block, the connection frame can be driven to move up and down, and then the guide column can be driven to move up and down. At this time, the filter frame can cooperate with the lower pressure frame to drive the two microporous filter plates to move downward. When the microporous filter plates move downward, the sodium heparin solution is forced to pass through the filtration of the two microporous filter plates and enter the top of the filter frame, while the impurities inside the sodium heparin are blocked by the microporous filter plates, so that when the sodium heparin is finely filtered with high purity, there is no need to use precipitation to filter and remove impurities from the sodium heparin solution, which effectively increases the filtering and purification efficiency of the sodium heparin solution. With the help of the hose and the weighted hollow ball, the filtered and purified heparin sodium solution can be pumped out to ensure the smooth discharge of the heparin sodium after high-purity fine filtration. By providing a disassembly port in conjunction with the microporous filter plate that is clamped with the filter frame, when one high-purity fine filtration and impurity removal work of heparin sodium is completed, it is only necessary to pull the microporous filter plate out of the filter frame through the disassembly port in conjunction with the disassembly frame and load a new microporous filter plate to quickly carry out the next high-purity fine filtration and impurity removal work of heparin sodium, so that the microporous filter plate can be easily disassembled and replaced, which is convenient for quickly carrying out the next heparin sodium impurity removal and purification work, and making the filtering and purification efficiency of the heparin sodium solution higher. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a three-dimensional structural diagram of the filter box of the utility model;

[0019] Figure 2 It is a three-dimensional structural schematic diagram of the collection box of the utility model;

[0020] Figure 3 It is a three-dimensional structural diagram of the hydraulic rod of the utility model;

[0021] Figure 4 It is a schematic diagram of the structure of the filter frame of the utility model in a cutaway three-dimensional view.

[0022] In the figure: 1. filter box; 2. collection box; 3. connecting block; 4. hydraulic rod; 5. connecting frame; 6. guide column; 7. filter frame; 8. lower pressure frame; 9. microporous filter plate; 10. disassembly frame; 11. water suction pump; 12. hose; 13. counterweight hollow ball; 14. mounting plate; 15. mounting hole; 16. sealing plate; 17. handle; 18. anti-slip sleeve; 19. locking block; 20. locking frame; 21. liquid filling pipe; 22. dust plug; 23. disassembly port; 24. sealing ring; 25. reinforcement sleeve; 26. fixing flange; 27. fixing through hole. DETAILED DESCRIPTION

[0023] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments.

[0024] Reference Figure 1-4 A high-purity heparin sodium fine filtration mechanism includes a filter box 1, a collection box 2 is arranged inside the filter box 1, and disassembly ports 23 are opened on the left and right sides of the filter box 1. The bottom surface of the filter box 1 is fixedly connected with a mounting plate 14, and the upper surface of the mounting plate 14 is provided with four mounting holes 15. The mounting plate 14 and the mounting holes 15 can be used with bolts and other fixing parts to fix the position of the device, so that the device is more firm and reliable when used.

[0025] The front and back sides of the filter box 1 are fixedly connected with connecting blocks 3, and the upper surface of each connecting block 3 is fixedly connected with a hydraulic rod 4. The left side of the collecting box 2 is fixedly connected with a sealing plate 16, and the right side of the sealing plate 16 is in contact with the left side of the filter box 1. The left side of the sealing plate 16 is fixedly connected with a handle 17, and the outer surface of the handle 17 is fixedly connected with an anti-slip sleeve 18. The sealing plate 16 can close the gap between the collecting box 2 and the filter box 1. Manually pulling the handle 17 in combination with the anti-slip sleeve 18 can facilitate the staff to take the collecting box 2 out, so as to facilitate the removal of the sodium heparin solution remaining in the collecting box 2.

[0026] The telescopic ends of the two hydraulic rods 4 are commonly fixedly connected to a connecting frame 5, the bottom surface of the connecting frame 5 is fixedly connected to a guide column 6, the front and back sides of the sealing plate 16 are fixedly connected to two locking blocks 19, the front and back sides of the filter box 1 are fixedly connected to two locking frames 20, each locking block 19 is snapped into the inside of the locking frame 20, and the locking blocks 19 cooperate with the locking frames 20 to fix the connection tightness between the sealing plate 16 and the filter box 1, so that the sealing plate 16 is not easy to loosen, thereby ensuring the sealing effect of the sealing plate 16.

[0027] The interior of the filter box 1 is slidably connected to a filter frame 7, the upper surface of the filter frame 7 is fixedly connected to a lower pressure frame 8, the bottom end of the guide column 6 passes through the filter box 1 and is fixedly connected to the upper surface of the lower pressure frame 8, two microporous filter plates 9 are clamped inside the filter frame 7, and the left side of the filter box 1 is fixedly connected to a liquid adding tube 21, the top of the liquid adding tube 21 is clamped with a dust plug 22, the liquid adding tube 21 can facilitate the staff to add the heparin sodium solution that needs high-purity fine filtration into the interior of the filter box 1, and the dust plug 22 can block the liquid adding tube 21 to prevent external impurities from contaminating the liquid adding tube 21.

[0028] The two microporous filter plates 9 are fixedly connected to a disassembly frame 10 on one side away from each other, and each disassembly frame 10 is clamped in the interior of the filter frame 7. The bottom surface of the filter frame 7 is fixedly connected to a sealing ring 24. The outer surface of the sealing ring 24 contacts the inner wall of the filter box 1. The sealing ring 24 can close the gap between the filter frame 7 and the filter box 1, making it difficult for the unfiltered sodium heparin solution to penetrate upward through the gap, thereby further ensuring the filtering and purification effect of the sodium heparin solution.

[0029] A water suction pump 11 is fixedly connected to the upper surface of the filter box 1, and the liquid inlet end of the water suction pump 11 passes through the filter box 1 and is fixedly connected to a hose 12. A reinforcement sleeve 25 is fixedly connected to the upper surface of the lower pressure frame 8, and the inner wall of the reinforcement sleeve 25 is fixedly connected to the outer surface of the guide column 6. The reinforcement sleeve 25 can increase the connection firmness between the lower pressure frame 8 and the guide column 6, make the connection between the guide column 6 and the lower pressure frame 8 less likely to deform, and improve the coordination effect of the lower pressure frame 8 and the guide column 6.

[0030] One end of the hose 12 away from the water suction pump 11 is fixedly connected to a weighted hollow ball 13, and a plurality of water inlet holes are provided on the outer surface of the weighted hollow ball 13. A fixed flange 26 is fixedly connected to the outer surface of the water outlet end of the water suction pump 11, and fixed through holes 27 arranged at equal distances are provided on the right side of the fixed flange 26. The fixed flange 26 cooperates with the fixed through holes 27 to facilitate the staff to connect the discharge pipe with the water suction pump 11, thereby ensuring that the filtered sodium heparin solution can be smoothly discharged and collected.

[0031] The working principle of the utility model is as follows: when in use, firstly, the hydraulic rod 4 and the water suction pump 11 are connected to the power supply, and then the filter box 1 is fixed at the position required for work through the mounting plate 14 and the mounting hole 15, and then the heparin sodium solution that needs high-purity fine filtration is added into the filter box 1 through the liquid adding pipe 21. At this time, the power provided by the hydraulic rod 4 cooperates with the connecting block 3 to drive the connecting frame 5 to move up and down, and then the guide column 6 can be driven to move up and down. At this time, the filter frame 7 can cooperate with the lower pressure frame 8 to drive the two microporous filter plates 9 to move downward. When the microporous filter plate 9 moves downward, the heparin sodium solution will be forced to pass through the filtration of the two microporous filter plates 9 and enter the top of the filter frame 7, while the impurities in the heparin sodium are blocked by the microporous filter plate 9. When the heparin sodium is subjected to high-purity fine filtration, there is no need to filter and remove impurities in the heparin sodium solution by precipitation, which effectively increases the passivation rate of the heparin sodium solution. The filtration and purification efficiency is improved. The suction provided by the water suction pump 11 cooperates with the hose 12 and the water inlet hole on the counterweight hollow ball 13 to extract the filtered and purified heparin sodium solution, ensuring the smooth discharge of the heparin sodium after high-purity fine filtration. When the high-purity fine filtration and impurity removal work of the heparin sodium is completed, the hydraulic rod 4 drives the filter frame 7 to move upward and return. It is only necessary to pull the microporous filter plate 9 out of the filter frame 7 through the disassembly port 23 and cooperate with the disassembly frame 10 to load a new microporous filter plate 9 to quickly carry out the next high-purity fine filtration and impurity removal work of the heparin sodium, so that the microporous filter plate 9 can be quickly disassembled and replaced, which is convenient for the next heparin sodium impurity removal and purification work to be carried out immediately, so that the filtration and purification efficiency of the heparin sodium solution is higher. When it is necessary to take out the residual heparin sodium solution in the collection box 2, it is only necessary to open the lock frame 20, manually pull the handle 17 to cooperate with the anti-slip sleeve 18 and the sealing plate 16 to pull the collection box 2 outward.

[0032] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0033] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present utility model, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0034] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes within the technical scope disclosed by the present invention according to the technical scheme and the utility model concept of the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A high-purity heparin sodium fine filtration mechanism, comprising a filter box (1), characterized in that: The filter box (1) is provided with a collecting box (2) inside, and the left and right sides of the filter box (1) are provided with disassembly openings (23). The front and back sides of the filter box (1) are fixedly connected with connecting blocks (3), and the upper surface of each connecting block (3) is fixedly connected with a hydraulic rod (4). The telescopic ends of the two hydraulic rods (4) are fixedly connected with a connecting frame (5), and the bottom surface of the connecting frame (5) is fixedly connected with a guide column (6). The filter box (1) is slidably connected with a filter frame (7), and the upper surface of the filter frame (7) is fixedly connected with a lower pressure frame (8). The guide column (6) ) passes through the filter box (1) and is fixedly connected to the upper surface of the lower pressure frame (8); two microporous filter plates (9) are clamped inside the filter frame (7); the two microporous filter plates (9) are fixedly connected to a disassembly frame (10) on one side away from each other; each disassembly frame (10) is clamped inside the filter frame (7); a water suction pump (11) is fixedly connected to the upper surface of the filter box (1); the liquid inlet end of the water suction pump (11) passes through the filter box (1) and is fixedly connected to a hose (12); the hose (12) is fixedly connected to a counterweight hollow ball (13) at one end away from the water suction pump (11).

2. A high-purity heparin sodium fine filtration mechanism according to claim 1, characterized in that: A mounting plate (14) is fixedly connected to the bottom surface of the filter box (1), and four mounting holes (15) are provided on the upper surface of the mounting plate (14).

3. A high-purity heparin sodium fine filtration mechanism according to claim 1, characterized in that: A sealing plate (16) is fixedly connected to the left side of the collection box (2), the right side of the sealing plate (16) contacts the left side of the filter box (1), a handle (17) is fixedly connected to the left side of the sealing plate (16), and an anti-slip sleeve (18) is fixedly connected to the outer surface of the handle (17).

4. A high-purity heparin sodium fine filtration mechanism according to claim 3, characterized in that: The front and back sides of the sealing plate (16) are fixedly connected to two locking blocks (19), the front and back sides of the filter box (1) are fixedly connected to two locking frames (20), and each of the locking blocks (19) is clamped inside the locking frame (20).

5. A high-purity heparin sodium fine filtration mechanism according to claim 1, characterized in that: The left side of the filter box (1) is fixedly connected to a liquid adding pipe (21), and the top end of the liquid adding pipe (21) is clamped with a dust plug (22).

6. A high-purity heparin sodium fine filtration mechanism according to claim 1, characterized in that: A sealing ring (24) is fixedly connected to the bottom surface of the filter frame (7), and the outer surface of the sealing ring (24) is in contact with the inner wall of the filter box (1).

7. A high-purity heparin sodium fine filtration mechanism according to claim 1, characterized in that: A reinforcing sleeve (25) is fixedly connected to the upper surface of the lower pressure frame (8), and the inner wall of the reinforcing sleeve (25) is fixedly connected to the outer surface of the guide column (6).

8. A high-purity heparin sodium fine filtration mechanism according to claim 1, characterized in that: A fixing flange (26) is fixedly connected to the outer surface of the water outlet end of the water suction pump (11), and the right side of the fixing flange (26) is provided with fixing through holes (27) arranged at equal distances.

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