Multi-dispersion-head temperature control high-speed homogenizer

Abstract

The utility model discloses a multi-dispersion head temperature control high-speed homogenizer which comprises a base and a lifting mechanism connected with the base, the lifting mechanism is connected with a driving mechanism, the driving mechanism can longitudinally move on the lifting mechanism, and the driving mechanism is connected with a homogenizing assembly. The homogenizing assembly comprises a mounting seat and a plurality of dispersing heads which are uniformly distributed and detachably connected to the mounting seat, and a temperature control platform which is matched with the dispersing heads and can longitudinally move on the lifting mechanism is arranged between the homogenizing assembly and the base; the temperature control platform is used for placing a to-be-treated sample and controlling the temperature of the to-be-treated sample through pre-cooling in advance. And the sample treatment speed can be increased, and heat generated during high-speed homogenization can be effectively eliminated.

Description

Technical Field

[0001] The utility model relates to the technical field of homogenizers, in particular to a multi-dispersing head temperature-controlled high-speed homogenizer. Background Art

[0002] The working principle of the high-speed homogenizer is to homogenize and crush animal or plant tissues at high speed through the internal suction homogenization structure, which can rupture the cell wall or cell membrane to separate the nucleus, thereby releasing the intracellular substances. Therefore, the high-speed homogenizer is often used to break biological tissues to recover DNA, RNA and proteins in cells. Subsequently, products such as animal organ homogenates, S9, microsomes, lysosomes, etc. can be prepared by filtration, gradient centrifugation, etc. for drug evaluation research. It is a commonly used tool for extracting and recovering biological samples.

[0003] However, the homogenizers currently on the market can only be connected to a single dispersion head, that is, only one sample can be processed at a time. For some samples that need to be processed in large quantities, they need to be transferred one by one to a single centrifuge tube or test tube and then homogenized one by one. This not only greatly increases the sample processing time, but also the difference in the homogenization time sequence between individual samples also leads to errors. In order to prevent contamination between individual samples, after processing a single sample, the dispersion head needs to be wiped and disinfected with alcohol before the next sample can be crushed, which also greatly increases the operational burden on the experimenter.

[0004] In addition, the homogenizers currently on the market will generate a certain amount of heat energy when running at high speed, which to a certain extent leads to the degradation and denaturation of some unstable test substances in the sample, such as metabolic enzymes and other proteins. Although some existing homogenizers are also equipped with temperature control systems, such as externally connected cooling systems (fans or liquid cooling devices, etc.), they are slow to take effect and cannot directly cool down the processed samples in a timely manner, which makes it impossible to eliminate the heat energy generated during the homogenization process. Utility Model Content

[0005] In view of the above-mentioned deficiencies of the current homogenizers, the utility model can speed up the sample processing speed and effectively eliminate the heat generated during high-speed homogenization.

[0006] In order to achieve the above object, the embodiment of the utility model adopts the following technical solution:

[0007] A multi-dispersing head temperature-controlled high-speed homogenizer, comprising a base and a lifting mechanism connected to the base, the lifting mechanism being connected to a driving mechanism, the driving mechanism being able to move longitudinally on the lifting mechanism, the driving mechanism being connected to a homogenizing assembly, the homogenizing assembly comprising a mounting seat and a plurality of dispersing heads evenly distributed and detachably connected to the mounting seat, a temperature-controlled platform cooperating with the dispersing heads and being able to move longitudinally on the lifting mechanism being provided between the homogenizing assembly and the base, the temperature-controlled platform being used for placing samples to be processed and achieving temperature control of the samples to be processed by pre-cooling in advance.

[0008] According to one aspect of the utility model, the lifting mechanism includes a lifting rod connected to the base and a lifting seat that can slide longitudinally on the lifting rod, and the lifting seat is connected to the driving mechanism.

[0009] According to one aspect of the utility model, the lifting seat is an electric lifting connector.

[0010] According to one aspect of the present invention, the mounting seat is a multi-connected integrated mounting seat.

[0011] According to one aspect of the present invention, the temperature control platform is made of anti-slip material.

[0012] According to one aspect of the utility model, a panel is provided on the base.

[0013] According to one aspect of the utility model, a connector is provided between the driving mechanism and the temperature control platform.

[0014] According to one aspect of the present invention, the driving mechanism includes a motor.

[0015] According to one aspect of the present invention, the temperature control platform is a temperature control panel.

[0016] According to one aspect of the utility model, the temperature control panel is provided with a plurality of placement holes for placing samples to be processed.

[0017] The advantages of the implementation of the utility model are as follows: multiple samples to be processed can be processed simultaneously through multiple dispersion heads, which greatly speeds up the sample processing speed and reduces the difference between samples caused by different sample processing times; the heat generated during high-speed homogenization is quickly reduced through the temperature control platform, so that the sample temperature can be kept at a low temperature to achieve the purpose of preventing sample degradation. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0019] Figure 1 A schematic diagram of the utility model;

[0020] Figure 2 It is a structural schematic diagram of the utility model.

[0021] 1. Base; 2. Lifting mechanism; 21. Lifting rod; 22. Lifting seat; 3. Driving mechanism; 4. Homogenization assembly; 41. Mounting seat; 42. Dispersing head; 5. Temperature control platform; 6. Panel; 7. Connector; 8. Sample to be processed. DETAILED DESCRIPTION

[0022] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0023] Embodiment 1:

[0024] A multi-dispersing head temperature-controlled high-speed homogenizer comprises a base 1 and a lifting mechanism 2 connected to the base 1, the lifting mechanism 2 is connected to a driving mechanism 3, the driving mechanism 3 can move longitudinally on the lifting mechanism 2, the driving mechanism 3 is connected to a homogenizing assembly 4, the homogenizing assembly 4 comprises a mounting seat 41 and a plurality of evenly distributed and detachably connected dispersing heads 42 on the mounting seat 41, a temperature control platform 5 is provided between the homogenizing assembly 4 and the base 1, which cooperates with the dispersing heads 42 and can move longitudinally on the lifting mechanism 2, the temperature control platform 5 is used to place the sample to be processed and to achieve temperature control of the sample to be processed by precooling in advance. When in use, the sample to be processed (i.e., the biological tissue to be homogenized placed in the homogenizing vessel) is placed on the precooled temperature control platform 5, and the lifting platform is adjusted to a suitable position (so that the dispersing head 42 is immersed in the liquid surface, but does not contact the bottom of the vessel), the homogenizing parameters (rotation speed), temperature and sample volume are set on the panel 6 of the base 1, and crushing is started. After the crushing is completed, the dispersing head 42 is removed and cleaned and disinfected with alcohol. Multiple disperser heads 42 can simultaneously process multiple samples 8 to be processed, which greatly speeds up the sample processing speed and reduces the difference between samples caused by different sample processing times. The heat generated during high-speed homogenization is quickly reduced by the temperature control platform 5, so that the sample temperature can be kept low to prevent sample degradation.

[0025] The dispersion head 42 may be a plurality of dispersion heads 42 , or one dispersion head 42 may be used to replace the plurality of dispersion heads 42 according to actual needs, so as to be suitable for sample processing methods under different conditions, thereby expanding the application scope and flexibility of the homogenizer.

[0026] The dispersing head 42 is detachably connected to the mounting base 41 to facilitate cleaning and disinfection before and after the test.

[0027] In this embodiment, the driving mechanism 3 is electrically connected to the lifting rod 21 .

[0028] In this embodiment, the number of the dispersing heads 42 is four.

[0029] In practical applications, the lifting mechanism 2 includes a lifting rod 21 connected to the base 1 and a lifting seat 22 that can slide longitudinally on the lifting rod 21 , and the lifting seat 22 is connected to the driving mechanism 3 .

[0030] In practical applications, the lifting seat 22 is an electric lifting connector, which ensures the normal operation of the lifting.

[0031] In practical applications, the mounting seat 41 is a multi-unit integrated mounting seat 41. The multi-unit integrated mounting seat 41 ensures that the dispersing head 42 can be stably and accurately mounted thereon.

[0032] In practical applications, the temperature control platform 5 is made of anti-slip material, which facilitates the lifting and lowering of the temperature control platform 5 to accommodate samples of different volumes.

[0033] In practical applications, the base 1 is provided with a panel 6. The homogenization parameters (rotation speed), temperature and sample volume can be set on the panel 6, reducing the operation steps and manual calculations, so as to facilitate rapid homogenization.

[0034] In practical applications, a connector 7 is provided between the driving mechanism 3 and the temperature control platform 5. The connector 7 is used to effectively and fixedly connect the driving mechanism 3 and the temperature control platform 5, thereby ensuring that during the homogenization process, the driving system can effectively transmit force to the temperature control platform 5 to achieve uniform mixing or crushing of the sample 8 to be processed.

[0035] In this embodiment, the connector 7 is a quick-connect connector 7, which is convenient and quick to install.

[0036] In practical applications, the driving mechanism 3 includes a motor.

[0037] In practical applications, the temperature control platform 5 is a temperature control panel 6. The temperature control panel 6 is used for precooling in advance, thereby eliminating the heat during homogenization in time, so as to achieve temperature control of the sample to be processed.

[0038] The temperature control panel can use a test tube cooling box with temperature control function, such as nalgene DS5116-0012, AMM-140D, etc.

[0039] In practical applications, the temperature control panel 6 is provided with a plurality of placement holes for placing samples to be processed.

[0040] The above is only a specific implementation of the utility model, but the protection scope of the utility model is not limited thereto. Any changes or substitutions that can be easily thought of by any technician familiar with the technical field within the technical scope disclosed in the utility model should be included in the protection scope of the utility model. Therefore, the protection scope of the utility model shall be based on the protection scope of the claims.

Claims

1. A multi-dispersing head temperature-controlled high-speed homogenizer, comprising a base (1) and a lifting mechanism (2) connected to the base (1), the lifting mechanism (2) being connected to a driving mechanism (3), the driving mechanism (3) being able to move longitudinally on the lifting mechanism (2), the driving mechanism (3) being connected to a homogenizing assembly (4), characterized in that: The homogenization assembly (4) comprises a mounting seat (41) and a plurality of dispersion heads (42) evenly distributed and detachably connected to the mounting seat (41); a temperature control platform (5) cooperating with the dispersion heads (42) and being longitudinally movable on the lifting mechanism (2) is provided between the homogenization assembly (4) and the base (1); the temperature control platform (5) is used to place samples to be processed and to achieve temperature control of the samples to be processed by precooling in advance.

2. A multi-dispersing head temperature-controlled high-speed homogenizer according to claim 1, characterized in that: The lifting mechanism (2) comprises a lifting rod (21) connected to the base (1) and a lifting seat (22) capable of longitudinally sliding on the lifting rod (21); the lifting seat (22) is connected to the driving mechanism (3).

3. A multi-dispersing head temperature-controlled high-speed homogenizer according to claim 2, characterized in that: The lifting seat (22) is an electric lifting connector (7).

4. A multi-dispersing head temperature-controlled high-speed homogenizer according to claim 2, characterized in that: The mounting seat (41) is a multi-connected integrated mounting seat (41).

5. A multi-dispersing head temperature-controlled high-speed homogenizer according to claim 1, characterized in that: The temperature control platform (5) is made of anti-slip material.

6. A multi-dispersing head temperature-controlled high-speed homogenizer according to claim 1, characterized in that: A panel (6) is provided on the base (1).

7. A multi-dispersing head temperature-controlled high-speed homogenizer according to claim 1, characterized in that: A connector (7) is provided between the driving mechanism (3) and the temperature control platform (5).

8. A multi-dispersing head temperature-controlled high-speed homogenizer according to claim 1, characterized in that: The driving mechanism (3) comprises a motor.

9. A multi-dispersing head temperature-controlled high-speed homogenizer according to any one of claims 1 to 8, characterized in that: The temperature control platform (5) is a temperature control panel (6).

10. A multi-dispersing head temperature-controlled high-speed homogenizer according to claim 9, characterized in that: The temperature control panel (6) is provided with a plurality of placement holes for placing samples to be processed.

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