Liposome wrapping device convenient to use

Abstract

The utility model relates to the technical field of wrapping machines, in particular to a lipidosome wrapping device convenient to use, which comprises a mounting plate, a four-way pipe is connected to one side of the mounting plate, a communicating pipe is connected to the four-way pipe, a stirring pipe is connected to the top of the four-way pipe, a wrapping mechanism is arranged in the communicating pipe, and the stirring pipe is connected to the other side of the four-way pipe. A stirring mechanism is arranged in the stirring pipe, the wrapping mechanism comprises a connecting rod, the connecting rod is slidably connected in a communicating pipe, the bottom of the connecting rod is fixedly connected with a disc, a filter membrane group is detachably connected in the communicating pipe, one side of the mounting plate is connected with a reciprocating screw rod, and one side of the mounting plate is provided with a driving assembly. And one side of the mounting plate is connected with a limiting assembly. According to the lipidosome wrapping device convenient to use, mixed liquid can repeatedly pass through the filter membrane set through the wrapping mechanism, so that the uniformity of wrapping objects is guaranteed, the mixing efficiency of the mixed liquid is improved through the stirring mechanism, and the working efficiency is greatly improved.

Description

Technical Field

[0001] The utility model relates to the technical field of packaging machines, in particular to a liposome packaging device that is easy to use. Background Art

[0002] Liposome is an artificial membrane. In water, the hydrophilic head of the phospholipid molecule is inserted into the water, and the hydrophobic tail of the liposome extends into the air. After stirring, a spherical liposome with a double layer of lipid molecules is formed, with a diameter ranging from 25 to 1000nm. Liposomes can be used for genetic modification or preparation of drugs. The characteristics of liposomes that can fuse with cell membranes are used to deliver drugs into cells. Biological definition: When amphiphilic molecules such as phospholipids and sphingolipids are dispersed in the aqueous phase, the hydrophobic tails of the molecules tend to gather together and avoid the aqueous phase, while the hydrophilic heads are exposed to the aqueous phase, forming a closed vesicle with a bilayer structure, called a liposome. Pharmaceutical definition: Liposome: refers to a microvesicle formed by encapsulating a drug in a lipid bilayer.

[0003] After searching, the Chinese patent with the publication number CN220111047U discloses a liposome reaction tank with a heat preservation function, which belongs to the field of liposome processing: the utility model discloses a liposome reaction tank with a heat preservation function, including a device shell, the interior of the device shell is provided with a stirring paddle; a heat storage cavity is provided between the heat preservation ring and the device shell, and a heat wrapping sheet is provided on one side of the heat storage cavity, and one side of the heat wrapping sheet is adhered and fixed to one side of the heat preservation ring. The utility model solves the problem that the heat of the existing liposome reaction tank will leak out during actual use, causing heat loss, so the reaction tank needs to be continuously heated, which requires increased power consumption. The heat is transferred to the interior of the heat germanium storage cavity through the device shell and blocked by the heat wrapping sheet. The heat is preserved and prevented from leaking out. At the same time, the heat stored in the heat germanium storage cavity can assist in processing the device shell and the material stirred inside.

[0004] The above patent has the following shortcomings: the liposome reaction tank with heat preservation function uses two syringes, one syringe containing liposomes is connected to the other syringe containing bag wrapping, and the two syringes are vibrated by reciprocating motion until the liposomes and drugs therein are evenly mixed, but this operation is laborious, the work efficiency is low, and the wrapping is uneven after mixing, which cannot meet the actual needs. In view of this, we propose a liposome wrapping device that is easy to use. Utility Model Content

[0005] The purpose of the utility model is to provide a liposome encapsulation device that is easy to use, so as to solve the problems raised in the above background technology.

[0006] In order to achieve the above purpose, the utility model provides the following technical solutions:

[0007] A liposome encapsulation device that is easy to use comprises: a mounting plate, one side of the mounting plate is connected to a four-way pipe, the four-way pipe is connected to a connecting pipe, the top of the four-way pipe is connected to a stirring pipe, a wrapping mechanism is arranged in the connecting pipe, a stirring mechanism is arranged in the stirring pipe, the wrapping mechanism comprises a connecting rod, the connecting rod is slidably connected in the connecting pipe, a disc is fixedly connected to the bottom of the connecting rod, a filter membrane group is detachably connected in the connecting pipe, a reciprocating screw is connected to one side of the mounting plate, a connecting block is threadedly connected to the reciprocating screw, the connecting block and the connecting rod are fixedly connected, a driving assembly is arranged on one side of the mounting plate, and a limiting assembly is connected to one side of the mounting plate.

[0008] Preferably, the stirring mechanism includes a stirring rod, which is rotatably connected in the stirring tube, and a stirring blade is fixedly connected to the stirring rod. A first bevel gear is connected to one side of the mounting plate, and a second bevel gear is meshingly connected to the first bevel gear. The second bevel gear is fixedly connected to the stirring rod.

[0009] Preferably, the driving assembly includes a motor, which is fixedly connected to one side of the mounting plate through a chassis, and the output end of the motor is fixedly connected to a rotating shaft through a coupling, and a fixed plate is fixedly connected to one side of the mounting plate, and the fixed plate is rotatably connected to the rotating shaft through a bearing, a third bevel gear is fixedly connected to the rotating shaft, a fourth bevel gear is meshedly connected to the third bevel gear, and the rotating shaft and the first bevel gear are fixedly connected.

[0010] Preferably, the limiting assembly comprises a limiting groove, the limiting groove is arranged on one side of the mounting plate, a limiting block is slidably connected in the limiting groove, and the limiting block is fixedly connected to the connecting block.

[0011] Preferably, a valve is connected to the bottom of the four-way pipe.

[0012] This setting can control the discharge of the device.

[0013] Preferably, a support plate is fixedly connected to one side of the mounting plate, and the support plate is rotatably connected via a bearing and a reciprocating screw.

[0014] Such an arrangement can support and fix the reciprocating screw rod.

[0015] Preferably, there are two connecting pipes, and a feed port is opened on one side.

[0016] This arrangement makes it easy to add materials to the device.

[0017] Compared with the prior art, the beneficial effects of the utility model are:

[0018] 1. A liposome encapsulation device that is easy to use, through the encapsulation mechanism, blank liposomes and objects to be encapsulated can be respectively introduced into two connecting tubes through the feed port, and then the motor is started to make the connecting block reciprocate. Since the connecting rod and the connecting block are fixedly connected, and the connecting rod and the disc are fixedly connected, the disc reciprocates, thereby pushing the liposomes and the objects to be encapsulated to the middle at the same time and mixing and flowing to the stirring tube, and at the same time, the mixed liquid will pass through the filter membrane group to obtain uniform encapsulation, and the mixed liquid will repeatedly pass through the filter membrane group, thereby ensuring the uniformity of the encapsulation.

[0019] 2. This easy-to-use liposome encapsulation device, through the stirring mechanism, the shaft rotates to drive the first bevel gear to rotate, so that the second bevel gear meshing with the first bevel gear rotates, so that the stirring rod fixedly connected to the second bevel gear drives the stirring blade to rotate, thereby accelerating the mixing efficiency of the mixed liquid and greatly improving the work efficiency. Finally, the valve is opened to guide the mixed liquid out to complete the liposome encapsulation. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a front view of the utility model;

[0021] Figure 2 It is a schematic diagram of the structure of the utility model;

[0022] Figure 3 This is an enlarged view of part A of the utility model;

[0023] Figure 4 It is an enlarged view of part B of the utility model.

[0024] In the figure: 1. mounting plate; 2. four-way pipe; 3. connecting pipe; 4. stirring pipe; 5. wrapping mechanism; 51. connecting rod; 52. disc; 53. filter membrane group; 54. reciprocating screw; 55. connecting block; 7. driving assembly; 71. motor; 72. rotating shaft; 73. fixing plate; 74. third bevel gear; 75. fourth bevel gear; 6. stirring mechanism; 61. stirring rod; 62. stirring blade; 63. first bevel gear; 64. second bevel gear; 8. limiting assembly; 81. limiting groove; 82. limiting block; 9. valve; 10. supporting plate. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0026] Liposome is an artificial membrane. The hydrophilic head of the phospholipid molecule is inserted into the water, and the hydrophobic tail of the liposome extends to the air. After stirring, a spherical liposome with a double layer of lipid molecules is formed, with a diameter ranging from 25 to 1000nm. Liposomes can be used for genetic modification or preparation of drugs. The characteristics of liposomes that can fuse with cell membranes are used to deliver drugs into cells. Biological definition: When amphiphilic molecules such as phospholipids and sphingolipids are dispersed in the aqueous phase, the hydrophobic tails of the molecules tend to gather together and avoid the aqueous phase, while the hydrophilic heads are exposed to the aqueous phase to form closed vesicles with a bilayer structure, called liposomes. Pharmacy definition: Liposome: refers to a microvesicle formed by encapsulating drugs in a lipid bilayer.

[0027] The existing liposome encapsulation machine uses two syringes, one syringe containing liposomes is connected to the other syringe containing bag packaging, and the two syringes are vibrated by reciprocating motion until the liposomes and drugs therein are evenly mixed. However, this operation is laborious, has low work efficiency, and the packaging is uneven after mixing, which cannot meet actual needs.

[0028] like Figure 1-4 As shown, a liposome encapsulation device that is easy to use comprises: a mounting plate 1, a four-way pipe 2 is connected to one side of the mounting plate 1, a connecting pipe 3 is connected to the four-way pipe 2, a stirring pipe 4 is connected to the top of the four-way pipe 2, a encapsulation mechanism 5 is arranged in the connecting pipe 3, a stirring mechanism 6 is arranged in the stirring pipe 4, the encapsulation mechanism 5 comprises a connecting rod 51, the connecting rod 51 is slidably connected in the connecting pipe 3, a disc 52 is fixedly connected to the bottom of the connecting rod 51, a filter membrane group 53 is detachably connected in the connecting pipe 3, a reciprocating screw rod 54 is connected to one side of the mounting plate 1, a connecting block 55 is threadedly connected to the reciprocating screw rod 54, the connecting block 55 is fixedly connected to the connecting rod 51, a driving assembly 7 is arranged on one side of the mounting plate 1, and a limiting assembly 8 is connected to one side of the mounting plate 1.

[0029] like Figure 2 As shown, the stirring mechanism 6 includes a stirring rod 61, which is rotatably connected to the stirring tube 4, and a stirring blade 62 is fixedly connected to the stirring rod 61. A first bevel gear 63 is connected to one side of the mounting plate 1, and a second bevel gear 64 is meshedly connected to the first bevel gear 63. The second bevel gear 64 and the stirring rod 61 are fixedly connected.

[0030] like Figure 2As shown, the drive assembly 7 includes a motor 71, which is fixedly connected to one side of the mounting plate 1 through a chassis, and the output end of the motor 71 is fixedly connected to a rotating shaft 72 through a coupling, and a fixed plate 73 is fixedly connected to one side of the mounting plate 1, and the fixed plate 73 is rotatably connected to the rotating shaft 72 through a bearing, and a third bevel gear 74 is fixedly connected to the rotating shaft 72, and a fourth bevel gear 75 is meshedly connected to the third bevel gear 74, and the rotating shaft 72 and the first bevel gear 63 are fixedly connected.

[0031] like Figure 2 As shown, the limiting assembly 8 includes a limiting groove 81, which is opened on one side of the mounting plate 1, and a limiting block 82 is slidably connected in the limiting groove 81, and the limiting block 82 and the connecting block 55 are fixedly connected.

[0032] like Figure 2 As shown, a valve 9 is connected to the bottom of the cross-way pipe 2.

[0033] Specifically, such an arrangement can control the discharge of the device.

[0034] like Figure 2 As shown, a support plate 10 is fixedly connected to one side of the mounting plate 1 , and the support plate 10 is rotatably connected via a bearing and a reciprocating screw 54 .

[0035] Specifically, such an arrangement can support and fix the reciprocating screw rod 54 .

[0036] like Figure 2 As shown, there are two connecting pipes 3, and a feed port is opened on one side.

[0037] Specifically, such an arrangement facilitates adding materials to the device.

[0038] The working principle of the utility model is as follows: blank liposomes and objects to be wrapped can be respectively introduced into the two connecting tubes 3 through the feed port, and then the motor 71 is started to rotate the rotating shaft 72 fixedly connected to the output end of the motor 71, and then the third bevel gear 74 and the fourth bevel gear 75 are driven to rotate the reciprocating screw rod 54, so that the connecting block 55 reciprocates. Since the connecting rod 51 and the connecting block 55 are fixedly connected, and the connecting rod 51 and the disc 52 are fixedly connected, the disc 52 reciprocates, so that the liposomes and the objects to be wrapped are simultaneously moved to the middle The mixture is pushed and mixed to flow toward the stirring tube 4. At the same time, the mixed liquid passes through the filter membrane group 53 to obtain a uniform inclusion. The mixed liquid repeatedly passes through the filter membrane group 53 to ensure the uniformity of the inclusion. At the same time, the rotating shaft 72 rotates to drive the first bevel gear 63 to rotate, so that the second bevel gear 64 meshing with the first bevel gear 63 rotates, so that the stirring rod 61 fixedly connected to the second bevel gear 64 drives the stirring blade 62 to rotate, thereby accelerating the mixing efficiency of the mixed liquid and greatly improving the work efficiency. Finally, the valve 9 is opened to guide the mixed liquid out to complete the liposome encapsulation.

[0039] The above shows and describes the basic principle, main features and advantages of the utility model. Those skilled in the art should understand that the utility model is not limited by the above embodiments. The above embodiments and descriptions are only preferred examples of the utility model and are not used to limit the utility model. Without departing from the spirit and scope of the utility model, the utility model may have various changes and improvements, which fall within the scope of the utility model to be protected. The scope of protection of the utility model is defined by the attached claims and their equivalents.

Claims

1. A liposome encapsulation device that is easy to use, characterized in that: include: Mounting plate (1); A four-way pipe (2) is connected to one side of the mounting plate (1), a connecting pipe (3) is connected to the four-way pipe (2), a stirring pipe (4) is connected to the top of the four-way pipe (2), a wrapping mechanism (5) is arranged in the connecting pipe (3), a stirring mechanism (6) is arranged in the stirring pipe (4), the wrapping mechanism (5) comprises a connecting rod (51), the connecting rod (51) is slidably connected in the connecting pipe (3), a disc (52) is fixedly connected to the bottom of the connecting rod (51), a filter membrane group (53) is detachably connected in the connecting pipe (3), a reciprocating screw rod (54) is connected to one side of the mounting plate (1), a connecting block (55) is threadedly connected to the reciprocating screw rod (54), the connecting block (55) and the connecting rod (51) are fixedly connected, a driving assembly (7) is arranged on one side of the mounting plate (1), and a limiting assembly (8) is connected to one side of the mounting plate (1).

2. The easy-to-use liposome encapsulation device according to claim 1, characterized in that: The stirring mechanism (6) comprises a stirring rod (61), the stirring rod (61) is rotatably connected in the stirring tube (4), a stirring blade (62) is fixedly connected to the stirring rod (61), a first bevel gear (63) is connected to one side of the mounting plate (1), a second bevel gear (64) is meshedly connected to the first bevel gear (63), and the second bevel gear (64) and the stirring rod (61) are fixedly connected.

3. The easy-to-use liposome encapsulation device according to claim 1, characterized in that: The driving assembly (7) comprises a motor (71), wherein the motor (71) is fixedly connected to one side of the mounting plate (1) via a chassis, an output end of the motor (71) is fixedly connected to a rotating shaft (72) via a coupling, a fixing plate (73) is fixedly connected to one side of the mounting plate (1), the fixing plate (73) is rotatably connected to the rotating shaft (72) via a bearing, a third bevel gear (74) is fixedly connected to the rotating shaft (72), a fourth bevel gear (75) is meshedly connected to the third bevel gear (74), and the rotating shaft (72) is fixedly connected to the first bevel gear (63).

4. The easy-to-use liposome encapsulation device according to claim 1, characterized in that: The limiting assembly (8) comprises a limiting groove (81), wherein the limiting groove (81) is provided on one side of the mounting plate (1), a limiting block (82) is slidably connected in the limiting groove (81), and the limiting block (82) and the connecting block (55) are fixedly connected.

5. The easy-to-use liposome encapsulation device according to claim 1, characterized in that: The bottom of the four-way pipe (2) is connected with a valve (9).

6. The easy-to-use liposome encapsulation device according to claim 1, characterized in that: A support plate (10) is fixedly connected to one side of the mounting plate (1), and the support plate (10) is rotatably connected via a bearing and a reciprocating screw rod (54).

7. The easy-to-use liposome encapsulation device according to claim 1, characterized in that: The number of the connecting pipes (3) is two, and a feed port is opened on one side.

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