Negative pressure system for degassing and biochemical analyzer

Abstract

The utility model provides a negative pressure system for degassing, the negative pressure system for degassing is a part of a biochemical analyzer, the negative pressure system for degassing comprises an analysis liquid path and a negative pressure tank, the analysis liquid path is used for conveying a reagent and analyzing ions in the reagent, and a degassing mechanism is arranged on the analysis liquid path; the negative pressure tank is provided with a pressure sensor used for reading the internal pressure value of the negative pressure tank, the negative pressure tank is connected with a negative pressure pump, a first electromagnetic valve is arranged between the negative pressure pump and the negative pressure tank, and the negative pressure tank is further connected with a second electromagnetic valve. A supply pipeline extends out of the negative pressure tank, and the negative pressure tank is connected with the degassing mechanism through the supply pipeline. Compared with the prior art, an accurate negative pressure value can be provided for the degassing mechanism through the negative pressure tank in the scheme, the stability of ion analysis in a reagent is guaranteed, and the negative pressure system in the scheme works independently and is convenient to maintain, regulate and control.

Description

Technical Field

[0001] The utility model belongs to the technical field of sample analysis, and particularly relates to a negative pressure system for degassing and a biochemical analyzer. Background Art

[0002] Electrolyte analyzers are instruments used to detect potassium ions, sodium ions, chloride ions, ionized calcium and lithium ions from samples. Samples can be reagents such as whole blood, serum, plasma, urine, dialysate and hydration fluid. The detection process of the electrolyte analyzer is that the syringe absorbs the reagent into the degassing mechanism through the suction and discharge device, and then discharges the reagent into the reaction container through the suction and discharge device. The reagent flows from the reaction container through the electrode, and its ion content is fed back in the form of an electrical signal to realize the analysis of the ions in the electrolyte.

[0003] During the detection process of the electrolyte analyzer, the degassing mechanism needs to have precise negative pressure. At present, the negative pressure is generally established by borrowing the vacuum pump-negative pressure tank path on the biochemical analyzer. The specific biochemical analyzer negative pressure system leads out a branch to the degassing mechanism of the electrolyte analyzer. The branch is connected in series with a pressure regulating valve or other pressure regulating devices to control the negative pressure of the biochemical analyzer negative pressure system branch to reach the required negative pressure value of the electrolyte analyzer degassing mechanism.

[0004] The above method of providing negative pressure to the degassing mechanism has the following problems:

[0005] 1. It is impossible to read the negative pressure value of the degassing mechanism of the electrolyte analyzer in real time, and it is impossible to know if there is a pressure leak.

[0006] 2. Based on question 1, even if the negative pressure value of the degassing mechanism of the electrolyte analyzer can be read by equipping it with a pressure sensor, once the pressure buildup fails or the pressure value does not reach the set value, the machine will report an error and maintenance will be difficult.

[0007] 3. The electrolyte analyzer uses the vacuum system of the biochemical analyzer to provide negative pressure for degassing, which affects each other. The negative pressure system on the biochemical analyzer generally involves the control of multiple solenoid valves when building pressure. When the electrolyte analyzer needs to build pressure, the life of the solenoid valve of the biochemical analyzer will also be consumed. Utility Model Content

[0008] In view of the above-mentioned shortcomings of the prior art, the purpose of the present invention is to provide a negative pressure system for degassing, so as to solve the problem that the negative pressure value of the degassing mechanism in the prior art cannot be accurately controlled.

[0009] In order to achieve the above-mentioned purpose and other related purposes, the technical solution of the utility model is as follows:

[0010] A negative pressure system for degassing, comprising:

[0011] An analytical liquid path, the analytical liquid path is used to transport the reagent and analyze the ions in the reagent, and a degassing mechanism is provided on the analytical liquid path;

[0012] A negative pressure tank is provided with a pressure sensor for reading its internal pressure value, the negative pressure tank is connected to a negative pressure pump, a first solenoid valve is provided between the negative pressure pump and the negative pressure tank, and the negative pressure tank is also connected to a second solenoid valve; a supply pipeline extends from the negative pressure tank, and the negative pressure tank and the degassing mechanism are connected through the supply pipeline.

[0013] Optionally, the supply pipeline is connected to a plurality of supply branches, and the supply branches are connected to the degassing mechanism.

[0014] Optionally, a float switch is provided inside the negative pressure tank.

[0015] Optionally, the upper end of the negative pressure tank is respectively provided with a pressure sensor interface, an output interface, and a pressure regulating interface, the pressure sensor interface is connected to the pressure sensor, the output interface is connected to the supply pipeline, and the pressure regulating interface is connected to the second solenoid valve.

[0016] Optionally, the negative pressure pump has an inlet and an outlet, the inlet is connected to the first solenoid valve, and the outlet is connected to an exhaust gas discharge point.

[0017] Optionally, the first solenoid valve is a pressure-building solenoid valve, and the second solenoid valve is a pressure-regulating solenoid valve.

[0018] Optionally, the analysis liquid circuit includes a suction liquid circuit and a reaction liquid circuit, wherein the suction liquid circuit is provided with a reagent bottle, a degassing mechanism, a first suction and discharge device, and a first syringe in sequence, and the reaction liquid circuit is provided with a reaction container, an ion selective electrode, a second suction and discharge device, and a second syringe in sequence, and the first suction and discharge device is connected to the reaction container.

[0019] Optionally, there are several suction liquid paths.

[0020] Optionally, the degassing mechanism is provided with a liquid inlet, a liquid outlet and a degassing port, the liquid inlet is connected to the reagent bottle, the liquid outlet is connected to the first suction and discharge device, and the degassing port is connected to the supply pipeline.

[0021] Correspondingly, the utility model also provides a biochemical analyzer, comprising:

[0022] A negative pressure system for degassing, wherein the negative pressure system for degassing is any one of the negative pressure systems for degassing described above;

[0023] The analyzer body is provided with the negative pressure system for degassing installed on the analyzer body.

[0024] As described above, in the utility model, negative pressure is provided to the degassing mechanism through the negative pressure tank, the negative pressure pump is first operated and the first solenoid valve is opened to establish negative pressure for the negative pressure tank, during which the negative pressure value in the negative pressure tank is read by the pressure sensor, and when the negative pressure in the negative pressure tank reaches the required value, the negative pressure pump and the first solenoid valve are closed. Since the start and stop of the negative pressure pump and the first solenoid valve have inertia, after the negative pressure pump and the first solenoid valve are closed, the negative pressure value in the negative pressure tank may exceed the required negative pressure value, at which time the second solenoid valve can be opened to release air and adjust the pressure until the negative pressure value in the negative pressure tank reaches the required negative pressure value and then the second solenoid valve is closed. Then the analysis liquid circuit is started to analyze the ions in the reagent, and the negative pressure in the negative pressure tank enters the degassing mechanism through the supply pipeline, which is used for the negative pressure required by the analysis liquid circuit. Compared with the prior art, the negative pressure tank in this scheme can provide the degassing mechanism with an accurate negative pressure value, thereby ensuring the stability of the ion analysis in the reagent, and the negative pressure system in this scheme works independently, which is convenient for maintenance and regulation. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 This is a schematic diagram of a negative pressure system for degassing according to an example of the present invention.

[0026] The description of the reference numerals in the embodiments includes:

[0027] The liquid suction circuit 100, the reagent bottle 110, the degassing mechanism 120, the liquid inlet 121, the liquid outlet 122, the degassing port 123, the first suction and discharge device 130, the first syringe 140,

[0028] Reaction liquid path 200, reaction container 210, ion selective electrode 220, second suction and discharge device 230, second syringe 240, reaction liquid discharge place 250,

[0029] Negative pressure tank 300 , pressure sensor interface 301 , pressure regulating interface 302 , output interface 303 , float switch 304 , pressure sensor 310 , second solenoid valve 320 , first solenoid valve 330 , negative pressure pump 340 , inlet end 341 , outlet end 342 , exhaust gas discharge point 350 , supply pipeline 360 ​​, supply branch 361 . DETAILED DESCRIPTION

[0030] In the following description, a large number of specific details are given to provide a more thorough understanding of the utility model. However, it is obvious to those skilled in the art that the utility model can be implemented without one or more of these details. In other examples, in order to avoid confusion with the utility model, some technical features known in the art are not described.

[0031] It should be understood that the utility model can be implemented in different forms and should not be construed as being limited to the embodiments presented herein. On the contrary, providing these embodiments will make the disclosure thorough and complete, and fully convey the scope of the utility model to those skilled in the art. In the accompanying drawings, the same reference numerals represent the same components throughout.

[0032] In the utility model, the biochemical analyzer is used in conjunction with an adapter reagent, and is mainly used for qualitative and / or quantitative analysis of human blood to be measured. This solution mainly describes the electrolyte analysis block in the biochemical analyzer and its corresponding negative pressure system. The biochemical analyzer includes a negative pressure system for degassing and an analyzer body 10, etc. The negative pressure system for degassing includes an analytical liquid circuit and a negative pressure tank 300 that can analyze ions in the reagent. In the biochemical analyzer, this negative pressure system is one of the modules, wherein the negative pressure system for degassing is the negative pressure system for degassing of any of the following embodiments.

[0033] The specific structure of the negative pressure system for degassing described in this embodiment is shown in FIG. Figure 1 , the negative pressure system for degassing comprises:

[0034] An analysis liquid path, the analysis liquid path is used to transport the reagent and analyze the ions in the reagent, and a degassing mechanism 120 is provided on the analysis liquid path;

[0035] A negative pressure tank 300 is provided with a pressure sensor 310 for reading the internal pressure value thereof, the negative pressure tank 300 is connected to a negative pressure pump 340, a first solenoid valve 330 is provided between the negative pressure pump 340 and the negative pressure tank 300, and the negative pressure tank 300 is also connected to a second solenoid valve 320; a supply pipeline 360 ​​extends from the negative pressure tank 300, and the negative pressure tank 300 and the degassing mechanism 120 are connected via the supply pipeline 360.

[0036] The analytical liquid circuit may be an electrolyte analysis module in an existing biochemical analyzer, i.e., a small module integrated with valves, a degassing mechanism 120, a dilution tank and other parts, for testing the Cl, Na, and K ion contents in the sample to be tested. The degassing mechanism 120 is used to remove tiny bubbles that may exist in the reagent, and to remove the tiny bubbles, a negative pressure of -32kPa to -33kPa needs to be established in the degassing mechanism 120. The negative pressure system established in the solution of the present invention can provide the required negative pressure value.

[0037] When the negative pressure system in this solution is used, the negative pressure pump 340 is first operated and the first solenoid valve 330 is opened to establish negative pressure in the negative pressure tank 300. During this process, the negative pressure value in the negative pressure tank 300 is read by the pressure sensor 310. When the negative pressure in the negative pressure tank 300 reaches the required value, the negative pressure pump 340 and the first solenoid valve 330 are closed. Since the start and stop of the negative pressure pump 340 and the first solenoid valve 330 have inertia, after the negative pressure pump 340 and the first solenoid valve 330 are closed, the negative pressure value in the negative pressure tank 300 may exceed the required negative pressure value. At this time, the second solenoid valve 320 can be opened to release air and adjust the pressure until the negative pressure value in the negative pressure tank 300 reaches the required negative pressure value and then the second solenoid valve 320 is closed.

[0038] Then, in the electrolyte analysis module, the analysis liquid circuit is started to analyze the ions in the reagent, and the negative pressure in the negative pressure tank 300 enters the degassing mechanism 120 through the supply pipeline 360, which is used to analyze the negative pressure required by the liquid circuit to detect the ion content.

[0039] In some embodiments, the supply pipeline 360 ​​is connected to a plurality of supply branches 361, and the supply branches 361 are connected to the degassing mechanism 120. For example, Figure 1 In the analysis liquid path, there are multiple degassing mechanisms 120. In order to ensure the negative pressure value in the multiple degassing mechanisms 120, a supply path 361 is used to supply negative pressure to the degassing mechanisms 120 one by one.

[0040] In some embodiments, a float switch 304 is disposed inside the negative pressure tank 300. For example, Figure 1 In the embodiment, a float switch 304 is provided in the negative pressure tank 300 to add a safeguard. In extremely special working environments and when components such as the pressure sensor 310 are damaged, the reagent will be directly pumped into the negative pressure tank 300 by the negative pressure system when flowing through the degassing mechanism 120. At this time, the flow rate of the negative pressure pump 340 is severely attenuated. The reagent continues to accumulate in the negative pressure tank 300 to trigger the sub-switch 304 alarm.

[0041] In some embodiments, the upper end of the negative pressure tank 300 is provided with a pressure sensor interface 301, an output interface 303, and a pressure regulating interface 302, wherein the pressure sensor interface 301 is connected to the pressure sensor 310, the output interface 303 is connected to the supply pipeline 360, and the pressure regulating interface 302 is connected to the second solenoid valve 320. For example, Figure 1 When the negative pressure tank 300 is in use, negative pressure is input from the bottom of the negative pressure tank 300 and negative pressure is output from the top of the negative pressure tank 300. Therefore, it is more reasonable that the sensor interface, the output interface 303 and the pressure regulating interface 302 are all located at the top of the negative pressure tank 300.

[0042] In some embodiments, the negative pressure pump 340 has an inlet 341 and an outlet 342, wherein the inlet 341 is connected to the first solenoid valve 330, and the outlet 342 is connected to the exhaust gas discharge 350. For example, Figure 1 In the figure, the left end of the negative pressure pump 340 is the inlet end 341, which is connected to the first solenoid valve 330 to input negative pressure into the negative pressure tank 300; the right end is the outlet end 342, which is connected to the exhaust gas discharge 350 to discharge the exhaust gas and a small amount of liquid generated during the operation of the negative pressure pump 340.

[0043] In some embodiments, the first solenoid valve 330 is a pressure-building solenoid valve, and the second solenoid valve 320 is a pressure-regulating solenoid valve. Figure 1 In the embodiment, the first solenoid valve 330 is opened mainly to input negative pressure into the negative pressure tank 300, so the solenoid valve can be a pressure-building solenoid valve, and the second solenoid valve 320 is opened to adjust the negative pressure value in the negative pressure tank 300, so the second solenoid valve 320 can be a pressure-regulating solenoid valve.

[0044] In some embodiments, the analysis liquid circuit includes a suction liquid circuit 100 and a reaction liquid circuit 200, and the suction liquid circuit 100 is sequentially provided with a reagent bottle 110, a degassing mechanism 120, a first suction and discharge device 130, and a first syringe 140, and the reaction liquid circuit 200 is sequentially provided with a reaction container 210, an ion selective electrode 220, a second suction and discharge device 230, and a second syringe 240, and the first suction and discharge device 130 is connected to the reaction container 210.

[0045] In the specific implementation process, for example, Figure 1 As shown, after the negative pressure tank 300 establishes the required negative pressure value, the first syringe 140 in the suction liquid circuit 100 draws the reagent from the reagent bottle 110 into the degassing mechanism 120 through the first suction and discharge device 130, and then discharges the reagent into the reaction container 210 through the first suction and discharge device 130, and reacts in the reaction container 210 to form a reaction liquid; then in the reaction liquid circuit 200, the reaction liquid flows through the ion selective electrode (ISE electrode) 220 through the second suction and discharge device 230 under the action of the second syringe 240. In the process of the reaction liquid flowing through each electrode, its ion content will be fed back in the form of an electrical signal, and the reaction waste liquid after the reaction is discharged to the waste liquid discharge through the second suction and discharge device 230.

[0046] In some embodiments, the suction liquid path 100 has a plurality of paths. For example, Figure 1 As shown, there are usually two aspiration liquid paths 100 because MID reagent and BUFFER reagent are required in the process.

[0047] In some embodiments, the degassing mechanism 120 is provided with a liquid inlet 121, a liquid outlet 122 and a degassing port 123, the liquid inlet 121 is connected to the reagent bottle 110, the liquid outlet 122 is connected to the first suction and discharge device 130, and the degassing port 123 is connected to the supply pipeline 360. For example, Figure 1 As shown, the liquid inlet 121 and the liquid outlet 122 are arranged at the upper part of the degassing device, and the degassing port 123 is located at the lower end of the degassing mechanism 120. According to the quality and flow direction of the liquid and gas, this arrangement is more reasonable.

[0048] The above embodiments are merely illustrative of the principles and effects of the present invention, and are not intended to limit the present invention. Anyone familiar with the technology may modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by a person of ordinary skill in the art without departing from the spirit and technical concept disclosed in the present invention shall still be covered by the claims of the present invention.

Claims

1. A negative pressure system for degassing, It is characterized in that include: An analytical liquid path, the analytical liquid path is used to transport the reagent and analyze the ions in the reagent, and a degassing mechanism is provided on the analytical liquid path; A negative pressure tank is provided with a pressure sensor for reading its internal pressure value, the negative pressure tank is connected to a negative pressure pump, a first solenoid valve is provided between the negative pressure pump and the negative pressure tank, and the negative pressure tank is also connected to a second solenoid valve; a supply pipeline extends from the negative pressure tank, and the negative pressure tank and the degassing mechanism are connected through the supply pipeline.

2. The negative pressure system for degassing according to claim 1, Features: The supply pipeline is connected with a plurality of supply branches, and the supply branches are connected with the degassing mechanism.

3. The negative pressure system for degassing according to claim 1, Features: A float switch is arranged inside the negative pressure tank.

4. The negative pressure system for degassing according to claim 1, Features: The upper end of the negative pressure tank is respectively provided with a pressure sensor interface, an output interface, and a pressure regulating interface, the pressure sensor interface is connected to the pressure sensor, the output interface is connected to the supply pipeline, and the pressure regulating interface is connected to the second solenoid valve.

5. The negative pressure system for degassing according to claim 4, Features: The negative pressure pump has an inlet end and an outlet end, the inlet end is connected to the first solenoid valve, and the outlet end is connected to the exhaust gas discharge point.

6. The negative pressure system for degassing according to claim 5, Features: The first solenoid valve is a pressure-building solenoid valve, and the second solenoid valve is a pressure-regulating solenoid valve.

7. A negative pressure system for degassing according to any one of claims 1 to 6, Features: The analysis liquid circuit includes a suction liquid circuit and a reaction liquid circuit, wherein a reagent bottle, a degassing mechanism, a first suction and discharge device, and a first syringe are sequentially arranged on the suction liquid circuit, and a reaction container, an ion selective electrode, a second suction and discharge device, and a second syringe are sequentially arranged on the reaction liquid circuit, and the first suction and discharge device is connected to the reaction container.

8. The negative pressure system for degassing according to claim 7, Features: The suction liquid paths include a plurality of paths.

9. The negative pressure system for degassing according to claim 8, Features: The degassing mechanism is provided with a liquid inlet, a liquid outlet and a degassing port, the liquid inlet is communicated with the reagent bottle, the liquid outlet is communicated with the first suction and discharge device, and the degassing port is communicated with the supply pipeline.

10. A biochemical analyzer, It is characterized in that include: A negative pressure system for degassing, wherein the negative pressure system for degassing is the negative pressure system for degassing according to any one of claims 1 to 9; The analyzer body is provided with the negative pressure system for degassing installed on the analyzer body.

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