Nano-drug production equipment based on microfluidic technology

Abstract

The utility model relates to the technical field of microfluidics, and discloses nano-drug production equipment based on the microfluidics technology, which comprises a main machine and an injector, the surface of the main machine is rotatably connected with a turnover door, a closed cavity is formed between the main machine and the turnover door, and the inner wall of the closed cavity is provided with a through groove. The nano-drug production equipment based on the microfluidic technology is provided with a host, an injector, a microfluidic chip box, a chip clamp module, a heating module and an injector propelling module, the injector is in butt joint with a liquid inlet of the microfluidic chip box, and the chip clamp module, the heating module and the injector propelling module are arranged in the host. The chip clamp module clamps the micro-fluidic chip box, the injector is installed on the micro-fluidic chip box and is in butt joint with the injector pushing module, the injector pushing module controls the pushing speed of the injector, and the heating module heats raw material liquid in the injector. Further, the flow speed of the raw material liquid entering the micro-fluidic chip box is controlled and the temperature of the raw material liquid is kept.

Description

Technical Field

[0001] The utility model relates to the technical field of microfluidics, in particular to nano drug production equipment based on microfluidics technology. Background Art

[0002] Microfluidics is a technology that precisely controls and manipulates microfluids. It mainly controls microfluids through micron- to sub-millimeter-level channels in microfluidic chip boxes. The chip is the operating platform. It is based on analytical chemistry, relies on micro-electromechanical processing technology, and has micro-pipeline networks as structural features. It is currently the main application object of life sciences and is the focus of the current development of micro-total analysis systems. Its goal is to integrate the functions of the entire laboratory, including sampling, dilution, reagent addition, reaction, synthesis, detection and other basic operating units, into a micron-scale chip.

[0003] When using a microfluidic chip box, the sample preparation, reaction, synthesis, and detection of the analysis process all require precise control of the flow rate of the raw material liquid injected into the microfluidic chip box, and the temperature of the raw material liquid needs to be maintained during the injection process. At present, manual operation is usually used for injection, which is troublesome and difficult to control the flow rate and maintain the temperature of the raw material liquid. Utility Model Content

[0004] In view of the deficiencies of the prior art, the utility model provides a nano drug production device based on microfluidic technology, which solves the problems mentioned in the above background.

[0005] The utility model provides the following technical solutions: nano drug production equipment based on microfluidic technology, including: a host, a chip fixture module, a microfluidic chip box, a heating module, a liquid receiving module, a syringe propulsion module and a syringe;

[0006] The microfluidic chip box is installed in the chip card slot of the chip clamp module, the chip clamp module is installed on the side wall of the host, and the heating module is installed below the chip clamp module and cooperates with the chip clamp module to form a syringe channel;

[0007] The movable end of the syringe propulsion module can move back and forth in the vertical direction, the lower end of the syringe is arranged on the movable end of the syringe propulsion module, and the upper end of the syringe passes through the syringe channel and docks with the liquid inlet of the microfluidic chip box;

[0008] The movable end of the liquid receiving module can move back and forth in the horizontal direction. The movable end of the liquid receiving module is provided with a liquid receiving pipe, and the pipe mouth of the liquid receiving pipe is connected with the liquid outlet of the microfluidic chip box.

[0009] Preferably, the chip clamp module includes an upper plate, a lower plate, a left mounting block, a right mounting block and a spring damping structure. The upper plate is installed on the top of the lower plate. A chip card slot is formed between the upper plate and the lower plate. The left mounting block and the right mounting block are respectively located on the left and right sides of the upper plate and are connected to the upper plate through corresponding spring damping structures.

[0010] Preferably, a chip identification hole is provided on the upper plate, pin holes are provided on the left and right sides of the upper plate, and a plurality of vertical holes are provided on the lower plate.

[0011] Preferably, the microfluidic chip box includes a shell and a microfluidic chip arranged in the shell, the liquid inlet and the liquid outlet are arranged on the lower surface of the shell, the liquid inlet is provided with a Luer connector, and the liquid inlet is connected to the syringe through the Luer connector.

[0012] Preferably, a microfluidic channel is provided in the microfluidic chip, the starting end of the microfluidic channel is connected to the liquid inlet, and the end of the microfluidic channel is connected to the liquid outlet;

[0013] The upper surface of the microfluidic chip box shell is provided with a mounting groove, and the mounting groove is used to install a magnet. The upper plate of the chip clamp module is provided with a suction piece, and the suction piece is arranged in a one-to-one correspondence with the magnet in the mounting groove and constitutes a first magnetic suction component. The microfluidic chip box is adsorbed and connected to the chip card slot of the chip clamp module through the first magnetic suction component.

[0014] Preferably, the heating module comprises a heating seat, a heating rod and a temperature sensor;

[0015] A heating groove is provided on one side of the heating seat and vertically penetrates from the upper end surface to the lower end surface thereof, and the heating rod and the temperature sensor are respectively installed on the other side of the heating seat.

[0016] Preferably, the lower plate of the chip clamp module and the heating seat are provided with a matching second magnetic attraction component, and the second magnetic attraction component can keep the syringe channel formed by the chip clamp module and the heating seat in a closed state.

[0017] Preferably, the heating module further comprises a heating sleeve, the heating sleeve is embedded in the heating groove, and the syringe is inserted into the heating sleeve.

[0018] Preferably, the liquid receiving module comprises: a liquid receiving pipe clamp, a rack, a mounting block, a gear and a first driving motor;

[0019] The mounting block is installed inside the main unit, the first drive motor is installed at the bottom of the mounting block, the gears are respectively installed inside the mounting blocks, and the central axes of the gears are connected to the output shafts of the first drive motors, the racks are installed in the bar-shaped grooves of the mounting block and mesh with the gears, the two ends of the racks extend out of the mounting block respectively, the liquid receiving pipe clamp is installed at one end of the racks, and the liquid receiving pipe is clamped on the liquid receiving pipe clamp.

[0020] Preferably, the syringe propulsion module comprises: a first mounting plate, a second mounting plate, a third mounting plate, a screw base, a ball screw, a slider, a syringe push piece and a second drive motor;

[0021] The first mounting plate, the second mounting plate, and the third mounting plate are sequentially arranged from bottom to top and are parallel to each other, the screw base is mounted on the second mounting plate, the second drive motor is mounted on the third mounting plate, a bearing is inlaid on the surface of the first mounting plate, the lower end of the ball screw is mounted on the first mounting plate through the bearing, the upper end of the ball screw passes through the second mounting plate and is connected to the screw base, and the output shaft of the second drive motor is connected to the top end of the ball screw through a coupling;

[0022] The slide block is sleeved on the ball screw, and the syringe push piece is coaxially arranged with the syringe and is installed and connected with the front end of the slide block.

[0023] Preferably, the syringe propulsion module further comprises: a pressure sensor, a contact sensor, a drag chain and a sensor sensing sheet;

[0024] The pressure sensor is installed on the syringe push piece and is used to monitor the pressure of the syringe push piece when pushing the syringe. One end of the drag chain is installed and connected to the rear end of the slider. The sensor sensing piece is installed on the side of the slider. The contact sensor is installed on the surface of the second mounting plate at a position corresponding to the sensor sensing piece.

[0025] Preferably, it further comprises a flip door, wherein the flip door is rotatably connected to the outer side wall of the host, and a receiving cavity is defined between the host and the flip door;

[0026] The chip fixture module, the microfluidic chip box, the heating module, the syringe, the liquid receiving tube of the liquid receiving module and the syringe pusher of the syringe propulsion module are all located in the accommodating cavity.

[0027] Preferably, the side wall of the accommodating cavity is composed of a first side wall, a second side wall and an arc-shaped side wall of the flip door, the first side wall is provided with a long through groove, and the second side wall is provided with a through hole;

[0028] The chip clamp module and the heating module are both installed on the first side wall, the movable end of the syringe propulsion module extends into the interior of the accommodating cavity through the through groove, and the movable end of the liquid receiving module extends into the interior of the accommodating cavity through the through hole.

[0029] Preferably, the host also includes a human-computer interaction module, which includes a touch screen, a power button, an indicator light and a mounting frame, the mounting frame is installed on the host, the mounting frame has an installation window, the touch screen is installed in the installation window of the mounting frame, and the power button and the indicator light are both installed on the mounting frame.

[0030] Preferably, the touch screen is rotatably connected to the mounting bracket.

[0031] Preferably, the host includes a control unit, and the microfluidic chip box, the heating module, the liquid receiving module, the syringe propulsion module, the touch screen, the power button and the indicator light are all electrically connected to the control unit.

[0032] Compared with the prior art, the utility model has the following beneficial effects:

[0033] 1. The nano drug production equipment based on microfluidic technology is provided with a host, a syringe, a microfluidic chip box, a chip clamp module, a heating module and a syringe propulsion module. The syringe is docked to the liquid inlet of the microfluidic chip box. The host has a chip clamp module, a heating module and a syringe propulsion module. The chip clamp module clamps the microfluidic chip box. The syringe is installed on the syringe propulsion module. The syringe propulsion module controls the speed of the syringe propulsion, and the heating module heats the raw material liquid in the syringe, thereby controlling the flow rate of the raw material liquid entering the microfluidic chip box and maintaining the temperature of the raw material liquid.

[0034] 2. In the nano-drug production equipment based on microfluidic technology, when the chip clamp module and the heating module are fastened together, a closed through hole is formed between the two. The syringe is located inside the closed through hole, which can prevent it from shifting during the injection process and avoid leakage at the joint between the syringe and the microfluidic chip box.

[0035] 3. This nano-drug production equipment based on microfluidic technology has a heating module that can be tightly attached to the wall of the syringe through sleeves of different sizes, and directly heats the raw liquid through heat conduction. It can not only more accurately control the heating temperature, heating time, and heating object, but also meet the experimental requirements under different working conditions.

[0036] 4. This nano-drug production equipment based on microfluidic technology uses a motor screw module direct connection mode to push the syringe to ensure the syringe's advancement accuracy. The syringe advancement module also contains a sensor array that can accurately sense the position of the push piece and the syringe, thereby achieving precise automated advancement and improving the advancement accuracy of the raw material liquid.

[0037] 5. The nano-drug production equipment based on microfluidic technology is provided with a liquid receiving module. The liquid receiving tube clamp of the liquid receiving module can clamp two liquid receiving tubes at the same time, one for receiving waste liquid and the other for receiving synthetic samples. The purpose of receiving waste liquid is to obtain a purer target sample. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] Figure 1 It is a schematic diagram of the structure of the utility model;

[0039] Figure 2 This is a schematic diagram of the structure of the chip fixture module of the utility model;

[0040] Figure 3 It is a partial structural schematic diagram of the chip fixture module of the utility model;

[0041] Figure 4 This is a schematic diagram of the structure of the microfluidic chip box of the utility model;

[0042] Figure 5 It is a structural schematic diagram of the liquid outlet and liquid inlet of the utility model;

[0043] Figure 6 This is a schematic diagram of the structure of the chip fixture module, microfluidic chip box and heating module after assembly;

[0044] Figure 7 This is a schematic diagram of the structure of the heating module of the utility model;

[0045] Figure 8 This is a schematic diagram of the structure of the heating sleeve installed in the heating module of the utility model;

[0046] Fig. 9 This is a schematic diagram of the structure of the liquid contact module of the utility model;

[0047] Fig.10 This is a structural schematic diagram of the syringe propulsion module of the utility model;

[0048] Fig.11 It is a structural schematic diagram of the human-computer interaction module of the utility model.

[0049] In the figure: 1. host; 2. flip door; 3. chip fixture module; 31. upper plate; 311. chip identification hole; 312. pin shaft hole; 32. lower plate; 321. vertical hole; 33. chip slot; 34. left mounting block; 35. right mounting block; 36. spring damping structure; 4. microfluidic chip box; 41. liquid outlet; 42. liquid inlet; 43. Luer connector; 44. mounting slot; 5. heating module; 51. heating seat; 52. heating slot; 53. heating rod; 54. temperature sensor; 55. heating sleeve; 6. liquid receiving module; 61. liquid receiving pipe clamp; 62. gear strip; 63, mounting block; 64, gear; 65, first drive motor; 7, syringe propulsion module; 70, bearing; 71, coupling; 72, contact sensor; 73, screw base; 74, drag chain; 75, ball screw; 76, sensor sensing sheet; 77, slider; 78, syringe pusher; 791, first mounting plate; 792, second mounting plate; 793, third mounting plate; 710, second drive motor; 8, human-computer interaction module; 81, touch screen; 82, power on / off button; 83, indicator light; 84, mounting bracket; 9, syringe; 10, liquid receiving tube. DETAILED DESCRIPTION

[0050] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0051] See also Figure 1-5 , a nano drug production device based on microfluidic technology, comprising: a host 1, a chip fixture module 3, a microfluidic chip box 4, a heating module 5, a liquid receiving module 6, a syringe propulsion module 7 and a syringe 9, the microfluidic chip box 4 is installed in the chip card slot 33 of the chip fixture module 3, the chip fixture module 3 is installed on the side wall of the host 1, the heating module 5 is installed below the chip fixture module 3 and cooperates with the chip fixture module 3 to form a syringe channel, the moving end of the syringe propulsion module 7 can move back and forth in the vertical direction, the lower end of the syringe 9 is arranged on the moving end of the syringe propulsion module 7, and the upper end of the syringe 9 passes through the syringe channel and docks with the liquid inlet 42 of the microfluidic chip box 4;

[0052] The movable end of the liquid receiving module 6 can move back and forth in the horizontal direction. The movable end of the liquid receiving module 6 is provided with a liquid receiving tube 10 , and the tube mouth of the liquid receiving tube 10 is connected to the liquid outlet 41 of the microfluidic chip box 4 .

[0053] See also Figure 2-3The chip fixture module 3 includes an upper plate 31, a lower plate 32, a left mounting block 34, a right mounting block 35 and a spring damping structure 36. The upper plate 31 is mounted on the top of the lower plate 32, and a chip card slot 33 is formed between the upper plate 31 and the lower plate 32. The left mounting block 34 and the right mounting block 35 are respectively located on the left and right sides of the upper plate 31 and are connected to the upper plate 31 through the corresponding spring damping structure 36. A chip identification hole 311 is opened on the upper plate 31, and pin shaft holes 312 are set on the left and right sides of the upper plate 31. A plurality of vertical holes 321 are opened on the lower plate 32 for observing the liquid in the syringe 9. The spring damping structure 36 is installed on the inner wall of the pin shaft hole 312, and the left mounting block 34 and the right mounting block 35 are connected to the upper plate 31 through the spring damping structure 36, so that the chip fixture module 3 can be controlled to flip and stay at any position within the range of motion.

[0054] See also Figure 4-5 The microfluidic chip box 4 includes a shell and a microfluidic chip arranged in the shell, a liquid inlet 42 and a liquid outlet 41 are arranged on the lower surface of the shell, a Luer connector 43 is arranged on the liquid inlet 42, and the liquid inlet 42 is connected to the syringe 9 through the Luer connector 43. A microfluidic channel is arranged in the microfluidic chip, the starting end of the microfluidic channel is connected to the liquid inlet 42, and the end of the microfluidic channel is connected to the liquid outlet 41;

[0055] See also Figure 5-6 The upper surface of the shell of the microfluidic chip box 4 is provided with a mounting groove 44, and the mounting groove 44 is used to install a magnet. The upper plate 31 of the chip clamp module 3 is provided with a suction piece (not shown in the figure), and the suction piece is arranged one-to-one with the magnet in the mounting groove 44 and constitutes a first magnetic suction component. The microfluidic chip box 4 is adsorbed and connected to the chip card slot 33 of the chip clamp module 3 through the first magnetic suction component.

[0056] See also Figure 7 The heating module 5 includes a heating seat 51, a heating rod 53 and a temperature sensor 54. A heating groove 52 is provided on one side of the heating seat 51 and vertically penetrates from the upper end surface to the lower end surface. The heating rod 53 and the temperature sensor 54 are respectively installed on the other side of the heating seat 51. The temperature sensor 54 adopts existing equipment, for example: a temperature sensor 54 of the model ZIM91-D5-L30-W50-V24.

[0057] Specifically in the present embodiment, the upper end surface of the heating seat 51 includes a plane and an arc-shaped inclined surface connected in sequence from back to front, and the arc-shaped inclined surface gradually inclines downward in the direction from back to front. The lower plate 32 is an L-shaped structure as a whole, and its vertical part is provided with a vertical hole 321, and its horizontal part includes two connecting ends arranged oppositely. The upper end surface of the connecting end is connected to the upper plate 31, and the lower end surface of the connecting end is set to an arc-shaped inclined surface for matching with the arc-shaped inclined surface of the heating seat 51.

[0058] The lower plate 32 of the chip clamp module 3 and the heating seat 51 are provided with a matching second magnetic attraction component, which can keep the syringe channel formed by the chip clamp module 3 and the heating seat 51 in a closed state. At this time, the syringe 9 can only move up and down along the syringe channel. By turning over the chip clamp module 3 with external force, the syringe channel can be changed from a closed state to an open state.

[0059] See also Figure 8 In a specific embodiment, the heating module 5 further includes a heating sleeve 55, which is embedded in the heating groove 52 and is used to wrap the tube wall of the syringe 9 to enhance the heating effect. Heating sleeves 55 of different specifications can be matched with syringes 9 of different specifications. The operator can see the model mark (e.g., 5ml) on the heating sleeve 55 through the vertical hole 321 of the chip fixture module 3, thereby confirming the model of the syringe 9 corresponding to the heating sleeve 55.

[0060] See also Fig. 9 The liquid receiving module 6 includes: a liquid receiving pipe clamp 61, a rack 62, a mounting block 63, a gear 64 and a first driving motor 65. The mounting block 63 is installed inside the main machine 1, the first driving motor 65 is installed at the bottom of the mounting block 63, the gears 64 are respectively installed inside the mounting block 63, and the central axis of the gear 64 is connected to the output shaft of the first driving motor 65. The rack 62 is installed in the bar groove of the mounting block 63 and meshes with the gear 64. The two ends of the rack 62 extend out of the mounting block 63 respectively. The liquid receiving pipe clamp 61 is installed at one end of the rack 62, and the liquid receiving pipe 10 is clamped on the liquid receiving pipe clamp 61.

[0061] Preferably, the liquid receiving tube clamp 61 is fixed in the groove of the rack 62 by magnet adsorption. In this way, it is convenient to replace reagent tube clamps of different specifications and sizes.

[0062] See also Fig.10The syringe propulsion module 7 includes: a first mounting plate 791, a second mounting plate 792, a third mounting plate 793, a screw base 73, a ball screw 75, a slider 77, a syringe push piece 78 and a second drive motor 710. The first mounting plate 791, the second mounting plate 792 and the third mounting plate 793 are arranged in sequence from bottom to top and are parallel to each other. The screw base 73 is mounted on the second mounting plate 792, and the second drive motor 710 is mounted on the third mounting plate 793. The surface of the first mounting plate 791 is inlaid with a bearing 70. The lower end of the ball screw 75 is mounted on the first mounting plate 791 through the bearing 70. The upper end of the ball screw 75 passes through the second mounting plate 792 and is connected to the screw base 73. The output shaft of the second drive motor 710 is connected to the top of the ball screw 75 through the coupling 71. The slider 77 is sleeved on the ball screw 75. The syringe push piece 78 is coaxially arranged with the syringe 9 and is installed and connected with the front end of the slider 77.

[0063] The syringe push module 7 also includes: a pressure sensor, a contact sensor 72, a drag chain 74 and a sensor sensing sheet 76. The pressure sensor is installed on the syringe push sheet 78 to monitor the pressure of the syringe push sheet 78 when pushing the syringe 9. The pressure sensor adopts existing equipment, for example: a pressure sensor of model ZKV01-1-ANS. One end of the drag chain 74 is installed and connected to the rear end of the slider 77. The sensor sensing sheet 76 is installed on the side of the slider 77. The contact sensor 72 is installed on the surface of the second mounting plate 792 at a position corresponding to the sensor sensing sheet 76. The contact sensor 72 is used to sense the proximity of the sensor sensing sheet 76, thereby locating and setting the initial position of the syringe push sheet 78. The contact sensor 72 adopts existing equipment, for example: a contact sensor 72 of model 72ZJF49-U25-N.

[0064] It also includes a flip door 2, which is rotatably connected to the outer wall of the main unit 1. A accommodating chamber is defined between the main unit 1 and the flip door 2. The first mounting plate 791, the second mounting plate 792, the third mounting plate 793, the screw base 73, the ball screw 75, the second drive motor 710 of the syringe propulsion module 7 and the mounting block 63, the gear 64, and the first drive motor 65 of the liquid receiving module 6 are all located outside the accommodating chamber, and the chip clamp module 3, the microfluidic chip box 4, the heating module 5, the syringe 9, the liquid receiving tube 10 of the liquid receiving module 6 and the syringe push piece 78 of the syringe propulsion module 7 are all located in the accommodating chamber.

[0065] Among them, the side wall of the accommodating chamber is composed of a first side wall, a second side wall and an arc-shaped side wall of the flip door 2. A long strip-shaped through groove is opened on the first side wall, and a through hole is opened on the second side wall. The chip clamp module 3 and the heating module 5 are both installed on the first side wall. The moving end of the syringe propulsion module 7 extends into the interior of the accommodating chamber through the through groove, and the moving end of the liquid receiving module 6 extends into the interior of the accommodating chamber through the through hole. Most of the components of the syringe propulsion module 7 and the liquid receiving module 6 are blocked outside the accommodating chamber, which can enhance the user experience.

[0066] In this embodiment, the first side wall and the second side wall are both planar structures and there is a preset angle (e.g., 90°) between the two side walls. In other embodiments, the first side wall and the second side wall may also be arcuate surfaces, and the first side wall and the second side wall are connected as a whole to form an arcuate side wall.

[0067] See also Fig.11 The host 1 also includes a human-computer interaction module 8, which includes a touch screen 81, a power button 82, an indicator light 83 and a mounting bracket 84. The mounting bracket 84 is installed on the host 1. The mounting bracket 84 has an installation window. The touch screen 81 is installed in the installation window of the mounting bracket 84. The power button 82 and the indicator light 83 are both installed on the mounting bracket 84.

[0068] In this embodiment, the human-computer interaction module 8 and the flip door 2 are both located at the front side of the host 1. When the flip door 2 is opened, the operator can see the touch screen 81 and the components in the accommodating cavity at the same time for easy operation.

[0069] Preferably, the touch screen 81 is rotatably connected to the mounting bracket 84. In this way, the screen can be flipped upward at a certain angle, which conforms to the ergonomic design and greatly enhances the interactive experience between people and the device.

[0070] The host 1 includes a control unit, and the microfluidic chip box 4, the heating module 5, the liquid receiving module 6 and the syringe propulsion module 7 are all electrically connected to the control unit. The touch screen 81, the power button 82 and the indicator light 83 are all electrically connected to the control unit.

[0071] The two syringes 9 are respectively connected to the liquid inlet 42 of the microfluidic chip box 4 through the Luer connector 43, and the syringe 9 is located in the closed through hole formed between the lower plate 32 and the heating seat 51. The surface of the syringe 9 is in contact with the inner wall of the heating groove 52. The heating rod 53 is started to control the temperature of the raw material liquid in the syringe 9. The bottom of the syringe 9 is connected to the syringe 9 push piece 78. The liquid receiving tube 10 is placed in the liquid receiving tube clamp 61. The first driving motor 65 is started. The output shaft of the first driving motor 65 drives the gear 64 to rotate. The gear 64 drives the rack 62 to move. The rack 62 drives the liquid receiving tube clamp 61 to move, so that one of the liquid receiving tubes 10 moves to the liquid outlet 41 of the microfluidic chip box 4. The second driving motor 710 is started. The second driving motor 710 drives the ball screw 75 to rotate, and the slider 77 sleeved on the ball screw 75 also moves accordingly, pushing one end of the syringe 9 to move, and the raw material liquid is injected into the interior of the microfluidic chip box 4.

[0072] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. Nano drug production equipment based on microfluidic technology, characterized in that: include: A host (1), a chip fixture module (3), a microfluidic chip box (4), a heating module (5), a liquid receiving module (6), a syringe propulsion module (7) and a syringe (9); The microfluidic chip box (4) is installed in the chip card slot (33) of the chip clamp module (3), the chip clamp module (3) is installed on the side wall of the host (1), and the heating module (5) is installed below the chip clamp module (3) and cooperates with the chip clamp module (3) to form an injector channel; The movable end of the syringe propulsion module (7) is capable of moving back and forth in a vertical direction, the lower end of the syringe (9) is arranged on the movable end of the syringe propulsion module (7), and the upper end of the syringe (9) passes through the syringe channel and docks with the liquid inlet (42) of the microfluidic chip box (4); The movable end of the liquid receiving module (6) is capable of moving back and forth in a horizontal direction. The movable end of the liquid receiving module (6) is provided with a liquid receiving tube (10), and the tube mouth of the liquid receiving tube (10) is connected to the liquid outlet (41) of the microfluidic chip box (4).

2. The nano drug production equipment based on microfluidic technology according to claim 1, characterized in that: The chip clamp module (3) comprises an upper plate (31), a lower plate (32), a left mounting block (34), a right mounting block (35) and a spring damping structure (36); the upper plate (31) is mounted on the top of the lower plate (32); a chip card slot (33) is formed between the upper plate (31) and the lower plate (32); the left mounting block (34) and the right mounting block (35) are respectively located on the left and right sides of the upper plate (31) and are connected to the upper plate (31) via corresponding spring damping structures (36).

3. The nano drug production equipment based on microfluidic technology according to claim 2, characterized in that: The upper plate (31) is provided with a chip identification hole (311), the left and right sides of the upper plate (31) are provided with pin shaft holes (312), and the lower plate (32) is provided with a plurality of vertical holes (321).

4. The nano drug production equipment based on microfluidic technology according to claim 2, characterized in that: The microfluidic chip box (4) comprises a shell and a microfluidic chip arranged in the shell, the liquid inlet (42) and the liquid outlet (41) are arranged on the lower surface of the shell, the liquid inlet (42) is provided with a Luer connector (43), and the liquid inlet (42) is connected to the syringe (9) through the Luer connector (43).

5. The nano drug production equipment based on microfluidic technology according to claim 4, characterized in that: A microfluidic channel is provided in the microfluidic chip, the starting end of the microfluidic channel is connected to the liquid inlet (42), and the end of the microfluidic channel is connected to the liquid outlet (41); The upper surface of the shell of the microfluidic chip box (4) is provided with a mounting groove (44), and the mounting groove (44) is used to install a magnet. The upper plate (31) of the chip clamp module (3) is provided with a suction piece, and the suction piece and the magnet in the mounting groove (44) are arranged one by one to form a first magnetic suction component. The microfluidic chip box (4) is adsorbed and connected to the chip card slot (33) of the chip clamp module (3) through the first magnetic suction component.

6. The nano drug production equipment based on microfluidic technology according to claim 2, characterized in that: The heating module (5) comprises a heating seat (51), a heating rod (53) and a temperature sensor (54); A heating groove (52) is provided on one side of the heating seat (51) and vertically penetrates from its upper end surface to its lower end surface. The heating rod (53) and the temperature sensor (54) are respectively installed on the other side of the heating seat (51).

7. The nano drug production equipment based on microfluidic technology according to claim 6, characterized in that: The lower plate (32) of the chip clamp module (3) and the heating seat (51) are provided with a matching second magnetic attraction component, and the second magnetic attraction component can keep the syringe channel formed by the chip clamp module (3) and the heating seat (51) in a closed state.

8. The nano drug production equipment based on microfluidic technology according to claim 6, characterized in that: The heating module (5) further comprises a heating sleeve (55), wherein the heating sleeve (55) is embedded in the heating groove (52), and the syringe (9) is inserted into the heating sleeve (55).

9. The nano drug production equipment based on microfluidic technology according to claim 1, characterized in that: The liquid receiving module (6) comprises: a liquid receiving pipe clamp (61), a rack (62), a mounting block (63), a gear (64) and a first driving motor (65); The mounting block (63) is mounted inside the main machine (1); the first drive motor (65) is mounted at the bottom of the mounting block (63); the gears (64) are respectively mounted inside the mounting blocks (63); and the central axis of the gears (64) is connected to the output shaft of the first drive motor (65); the rack (62) is mounted in the bar-shaped groove of the mounting block (63) and meshes with the gear (64); both ends of the rack (62) extend out of the mounting block (63); the liquid receiving pipe clamp (61) is mounted on one end of the rack (62); and the liquid receiving pipe (10) is clamped on the liquid receiving pipe clamp (61).

10. The nano drug production equipment based on microfluidic technology according to claim 1, characterized in that: The syringe propulsion module (7) comprises: a first mounting plate (791), a second mounting plate (792), a third mounting plate (793), a screw base (73), a ball screw (75), a slider (77), a syringe pusher (78) and a second drive motor (710); The first mounting plate (791), the second mounting plate (792), and the third mounting plate (793) are arranged in sequence from bottom to top and are parallel to each other; the screw base (73) is mounted on the second mounting plate (792); the second drive motor (710) is mounted on the third mounting plate (793); a bearing (70) is inlaid on the surface of the first mounting plate (791); the lower end of the ball screw (75) is mounted on the first mounting plate (791) via the bearing (70); the upper end of the ball screw (75) passes through the second mounting plate (792) and is connected to the screw base (73); and the output shaft of the second drive motor (710) is connected to the top end of the ball screw (75) via a coupling (71); The slider (77) is sleeved on the ball screw (75), and the syringe push piece (78) is coaxially arranged with the syringe (9) and is installed and connected with the front end of the slider (77).

11. The nano drug production device based on microfluidic technology according to claim 10, characterized in that: The syringe propulsion module (7) further comprises: a pressure sensor, a contact sensor (72), a drag chain (74) and a sensor sensing sheet (76); The pressure sensor is installed on the syringe push piece (78) and is used to monitor the pressure of the syringe push piece (78) when pushing the syringe (9). One end of the drag chain (74) is connected to the rear end of the slider (77). The sensor sensing piece (76) is installed on the side of the slider (77). The contact sensor (72) is installed on the surface of the second mounting plate (792) at a position corresponding to the sensor sensing piece (76).

12. The nano drug production equipment based on microfluidic technology according to claim 1, characterized in that: It also comprises a flip door (2), the flip door (2) being rotatably connected to the outer side wall of the main unit (1), and a containing cavity is defined between the main unit (1) and the flip door (2); The chip clamp module (3), the microfluidic chip box (4), the heating module (5), the syringe (9), the liquid receiving tube (10) of the liquid receiving module (6), and the syringe push piece (78) of the syringe propulsion module (7) are all located in the accommodating cavity.

13. The nano drug production device based on microfluidic technology according to claim 12, characterized in that: The side wall of the accommodating cavity is composed of a first side wall, a second side wall and an arc-shaped side wall of the flip door (2); the first side wall is provided with a long strip-shaped through groove, and the second side wall is provided with a through hole; The chip clamp module (3) and the heating module (5) are both installed on the first side wall, the movable end of the syringe propulsion module (7) extends into the interior of the accommodating cavity through the through groove, and the movable end of the liquid receiving module (6) extends into the interior of the accommodating cavity through the through hole.

14. The nano drug production equipment based on microfluidic technology according to claim 1, characterized in that: The host (1) further comprises a human-machine interaction module (8), the human-machine interaction module (8) comprising a touch screen (81), an on / off button (82), an indicator light (83) and a mounting frame (84), the mounting frame (84) being mounted on the host (1), the mounting frame (84) being provided with an installation window, the touch screen (81) being mounted in the installation window of the mounting frame (84), and the on / off button (82) and the indicator light (83) being both mounted on the mounting frame (84).

15. The nano drug production device based on microfluidic technology according to claim 14, characterized in that: The touch screen (81) is rotatably connected to the mounting frame (84).

16. The nano drug production device based on microfluidic technology according to claim 15, characterized in that: The host (1) comprises a control unit, and the microfluidic chip box (4), the heating module (5), the liquid receiving module (6), the syringe propulsion module (7), the touch screen (81), the power button (82) and the indicator light (83) are all electrically connected to the control unit.

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