Solid-liquid centrifugal device for ivabradine hydrochloride bulk drug
By using a solid-liquid centrifugal device with a cone column and a limiting ring in the preparation process of ivabradin hydrochloride, the problem of difficulty in collecting solid materials is solved, and efficient solid-liquid separation and reducing material residues are achieved.
Patent Information
- Application Number
- CN202420890768.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-04-26
- Publication Date
- 2024-12-31
- Estimated Expiration
- 2034-04-26
AI Technical Summary
During the preparation of ivabradin hydrochloride, existing centrifuges are difficult to effectively collect solid materials, resulting in the easy tightening of the solid-liquid separation of subsequent batches.
A solid-liquid centrifugal device including a shell, filter cartridge, filter bag, conical column and limit ring is designed. The filter cartridge is equipped with a conical column and an inner convex bag to increase the contact area and stability of the material. There is a passage and an inner convex bag. A ring and a limiting ring are provided on the outside of the filter cartridge to support the filter bag. The motor drives the filter cartridge to rotate, and the filter bag can be taken out as a whole for easy collection of solid materials.
The solid-liquid separation of ivabrading hydrochloride is achieved, which facilitates solid material collection, reduces material residues, and improves filtration efficiency and filter bag stability.
Smart Images
Figure CN222267454U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of raw material medicine production, in particular to a solid-liquid centrifuge device for ivabradine hydrochloride raw material medicine. Background Art
[0002] Ivabradine hydrochloride is a drug used to treat cardiovascular diseases. It can be widely used to treat or prevent various clinical conditions of myocardial ischemia, such as angina pectoris, myocardial infarction and accompanying rhythm disorders. It can also be used to treat heart failure and help improve the cardiac function and quality of life of patients with heart failure.
[0003] In the preparation process of ivabradine hydrochloride, ivabradine hydrochloride is dissolved in a solvent and then added to a non-solvent, a mixed solution is formed by stirring, and then cooled to cause ivabradine hydrochloride to precipitate from the solution. The precipitated ivabradine hydrochloride needs to be separated from the solid by a centrifuge. In the existing centrifuge, solid materials are easily fixed on the centrifuge after solid-liquid separation, especially on the inner wall of the filter cartridge, which makes collection difficult and cumbersome, consumes a lot of manpower, and if the residual solid materials are not collected cleanly, they will affect the solid-liquid separation of subsequent batches. Utility Model Content
[0004] The utility model aims to provide a solid-liquid centrifuge for ivabradine hydrochloride raw material medicine, which can separate the solid and liquid of ivabradine hydrochloride during its preparation process, facilitate the collection of solid materials, avoid the solid materials from being fastened to the inner wall of the filter cartridge, and effectively reduce material residues.
[0005] To achieve the above-mentioned purpose, the technical solution adopted by the utility model is: a solid-liquid centrifuge device for ivabradine hydrochloride raw material medicine, including a machine base, a shell is fixedly provided on the machine base, a filter cartridge is rotatably connected inside the shell, a power source for driving the filter cartridge to rotate is provided below the filter cartridge, and a filter bag matching its inner cavity is provided inside the filter cartridge.
[0006] A further improvement of the utility model is that a cone column is provided on the inner bottom surface of the filter cartridge, a through opening is provided on the filter bag, and an inner convex sleeve bag matching with the cone column is provided on the through opening.
[0007] A further improvement of the utility model is that a circular ring is coaxially and horizontally provided on the outer side of the filter cartridge opening, and a limiting ring whose lower end surface contacts the upper end surface of the circular ring is coaxially provided on the outer side of the filter bag opening.
[0008] A further improvement of the utility model is that a feeding port is provided at the upper end of the shell, a sealing cover is hinged on one side of the feeding port, and the sealing cover is fixed to the shell by a fixing member.
[0009] A further improvement of the utility model is that the filter cartridge is provided with water filtering holes at even intervals, and one side of the shell is provided with a liquid discharge port.
[0010] A further improvement of the utility model is that the power source includes a motor arranged on one side of the shell, and a rotating shaft is provided at the lower end of the filter cartridge. The rotating shaft passes through the shell and is sealed and rotatably connected to the shell, and the rotating shaft is transmission-connected to the motor.
[0011] A further improvement of the utility model is that a through hole is coaxially provided on the cone column, and the rotating shaft is fixedly connected to the filter cartridge through the through hole.
[0012] A further improvement of the utility model is that a nitrogen interface is provided on the sealing cover, a control valve is provided at the upper end of the nitrogen interface, and a ventilation pipe located in the filter cartridge is provided at the lower end of the nitrogen interface.
[0013] A further improvement of the utility model is that a plurality of pin holes are provided on the circular ring and the limiting ring, and the pin holes of the two are arranged in a one-to-one correspondence and fixed by a pin shaft.
[0014] The beneficial effects of the utility model are:
[0015] The utility model can separate the solid and liquid of ivabradine hydrochloride during its preparation process, and can facilitate the collection of solid materials by arranging a filter bag in the filter cartridge. When collecting, the solid materials in the filter bag can be obtained by simply taking out the filter bag as a whole, thereby effectively preventing the solid materials from being fastened to the inner wall of the filter cartridge and reducing material residue.
[0016] The utility model arranges a cone column in the filter cartridge, and supports the inner convex sleeve bag through the conical surface of the cone column, thereby increasing the contact area between the material and the filter bag and improving the filtration efficiency. The support by the cone column can limit the movement of the filter bag and improve the stability of the filter bag during rotation and centrifugation.
[0017] The utility model can support the upper end of the filter bag by arranging a limiting ring in contact with the upper end surface of the circular ring, thereby reducing the collapse of the filter bag and maintaining the stability of the filter bag structure during centrifugal rotation. BRIEF DESCRIPTION OF THE DRAWINGS
[0018] Figure 1 It is a structural schematic diagram of the utility model.
[0019] In the figure, 1-base, 2-shell, 3-filter cartridge, 4-filter bag, 5-conical column, 6-inward convex sleeve, 7-circular ring, 8-limiting ring, 9-sealing cover, 10-water filter hole, 11-drain port, 12-motor, 13-rotating shaft, 14-nitrogen interface, 15-vent pipe. DETAILED DESCRIPTION
[0020] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.
[0021] Example 1: Combination Figure 1 It can be seen that a solid-liquid centrifuge device for ivabradine hydrochloride raw material medicine is characterized by comprising a machine base 1, a shell 2 is fixedly provided on the machine base 1, a filter cartridge 3 is rotatably connected in the shell 2, a power source for driving the filter cartridge 3 to rotate is provided below the filter cartridge 3, and a filter bag 4 matched with the inner cavity of the filter cartridge 3 is provided in the filter cartridge 3. The filter bag 4 is made of filter cloth, and preferably, the filter cloth is a 300-mesh or 400-mesh filter cloth.
[0022] A cone column 5 is provided on the inner bottom surface of the filter cartridge 3, a through opening is provided on the filter bag 4, and an inner convex sleeve bag 6 matching the cone column 5 is provided on the through opening. Preferably, a plane is provided on the top of the cone column 5, and a hemisphere is detachably connected to the plane.
[0023] A circular ring 7 is coaxially arranged horizontally on the outer side of the filter cartridge 3, and a limiting ring 8 is coaxially arranged on the outer side of the filter bag 4, whose lower end surface contacts the upper end surface of the circular ring 7. The limiting ring 8 is made of the same material as the filter bag 4. A plurality of pin holes are arranged on the circular ring 7 and the limiting ring 8, and the pin holes of the two are arranged one-to-one and fixed by a pin shaft. Preferably, at least three groups of pin holes are arranged on the circular ring 7 and the limiting ring 8. A fixing ring for preventing deformation is arranged on the pin hole of the limiting ring 8.
[0024] The upper end of the housing 2 is provided with a feeding port, and a sealing cover 9 is hinged on one side of the feeding port, and the sealing cover 9 is fixed to the housing 2 through a fixing member. The filter cartridge 3 is provided with water filtering holes 10 at even intervals, and a liquid discharge port 11 is provided on one side of the housing 2. A sealing ring is provided between the feeding port and the sealing cover 9. Preferably, the fixing member is a convex piece provided on one side of the sealing cover, and a first screw hole is provided on the convex piece, and a second screw hole matching the first screw hole is provided on the housing 2, and the first screw hole and the second screw hole are fixed by bolts.
[0025] The power source includes a motor 12 disposed on one side of the housing 2. A rotating shaft 13 is disposed at the lower end of the filter cartridge 3. The rotating shaft 13 passes through the housing 2 and is sealed and rotatably connected to the housing 2. The rotating shaft 13 is transmission-connected to the motor 12. A through hole is coaxially disposed on the cone column 5, and the rotating shaft 13 is fixedly connected to the filter cartridge 3 through the through hole.
[0026] A nitrogen interface 14 is provided on the sealing cover 9 , a control valve is provided at the upper end of the nitrogen interface 14 , and a vent pipe 15 located in the filter cartridge is provided at the lower end of the nitrogen interface 14 .
[0027] The working principle of the solid-liquid centrifuge device for ivabradine hydrochloride raw material provided by the utility model is as follows: when working, the mixed liquid is poured into the filter bag 4, the sealing cover 9 is closed, and the motor 12 is started. The motor 12 drives the rotating shaft 13 to rotate, and the rotating shaft 13 then drives the filter cartridge 3 and the filter bag 4 to rotate. The mixed liquid in the filter bag 4 is thrown to its side, and the solid ivabradine hydrochloride will remain on the filter bag 4, and the liquid will pass through the filter bag 4 and the water filter hole into the space between the shell 2 and the filter cartridge 3, and then flow out from the drain port 11. When collecting, you only need to take out the filter bag 4 as a whole to get the solid material in the filter bag 4, which effectively avoids the solid material from being fastened to the inner wall of the filter cartridge 3 and reduces material residue.
[0028] In the description of the present utility model, it should be understood that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inside", "outside", etc. indicate directions or positional relationships based on the directions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as a limitation on the present utility model. Any equivalent structure or equivalent process transformation made using the contents of the utility model specification and the accompanying drawings, or directly or indirectly used in other related technical fields, are similarly included in the patent protection scope of the present utility model.
Claims
1. A solid-liquid centrifuge for ivabradine hydrochloride bulk drug, characterized in that: The invention comprises a machine base (1), a shell (2) being fixedly provided on the machine base (1), a filter cartridge (3) being rotatably connected inside the shell (2), a power source for driving the filter cartridge (3) to rotate being provided below the filter cartridge (3), and a filter bag (4) cooperating with the inner cavity of the filter cartridge (3) being provided inside the filter cartridge (3).
2. A solid-liquid centrifuge for ivabradine hydrochloride bulk drug according to claim 1, characterized in that: A conical column (5) is provided on the inner bottom surface of the filter cartridge (3), a through opening is provided on the filter bag (4), and an inner convex sleeve bag (6) matching the conical column (5) is provided on the through opening.
3. A solid-liquid centrifuge for ivabradine hydrochloride bulk drug according to claim 1, characterized in that: A circular ring (7) is coaxially and horizontally arranged on the outer side of the filter cartridge (3) at the cartridge opening, and a limiting ring (8) is coaxially arranged on the outer side of the filter bag (4) at the bag opening, the lower end surface of the limiting ring (8) being in contact with the upper end surface of the circular ring (7).
4. A solid-liquid centrifuge for ivabradine hydrochloride bulk drug according to claim 1, characterized in that: A feeding port is provided at the upper end of the shell (2), a sealing cover (9) is hingedly connected to one side of the feeding port, and the sealing cover (9) is fixed to the shell (2) via a fixing member.
5. The solid-liquid centrifuge device for ivabradine hydrochloride bulk drug according to claim 1, characterized in that: The filter cartridge (3) is provided with water filtering holes (10) at even intervals, and one side of the housing (2) is provided with a liquid discharge port (11).
6. A solid-liquid centrifuge for ivabradine hydrochloride bulk drug according to claim 2, characterized in that: The power source comprises a motor (12) arranged on one side of the housing (2); a rotating shaft (13) is provided at the lower end of the filter cartridge (3); the rotating shaft (13) passes through the housing (2) and is rotatably connected to the housing (2) in a sealed manner; and the rotating shaft (13) is drivingly connected to the motor (12).
7. The solid-liquid centrifuge device for ivabradine hydrochloride bulk drug according to claim 6, characterized in that: A through opening is coaxially provided on the conical column (5), and the rotating shaft (13) is fixedly connected to the filter cartridge (3) via the through opening.
8. The solid-liquid centrifuge device for ivabradine hydrochloride bulk drug according to claim 4, characterized in that: The sealing cover (9) is provided with a nitrogen interface (14), the upper end of the nitrogen interface (14) is provided with a control valve, and the lower end of the nitrogen interface (14) is provided with a ventilation pipe (15) located in the filter cartridge.
9. The solid-liquid centrifuge device for ivabradine hydrochloride bulk drug according to claim 3, characterized in that: The circular ring (7) and the limiting ring (8) are both provided with a plurality of pin holes, and the pin holes of the two are arranged in a one-to-one correspondence and fixed by a pin shaft.