Filtering device for filtering impurities in synthesis process of parecoxib sodium

Abstract

The utility model discloses a filtering device for filtering impurities in a parecoxib sodium synthesis process, and relates to the technical field of parecoxib sodium production, the filtering device comprises a conveying pipeline for conveying a parecoxib sodium solution and a heat-conducting pipeline loaded with a heat-conducting medium, the two ends of the conveying pipeline are open, and the two ends of the conveying pipeline are open. The heat conduction pipeline is connected with the conveying pipeline in a sleeved mode and located in the conveying pipeline. An annular filtering channel is formed between the inner wall of the conveying pipeline and the outer wall of the heat conduction pipeline, an annular filtering piece used for filtering active carbon particles in the conveyed parecoxib sodium solution is arranged in the annular filtering channel, and the inner wall of the inner ring of the annular filtering piece abuts against the outer wall of the heat conduction pipeline. The outer wall of the outer ring of the annular filtering piece abuts against the inner wall of the conveying pipeline; according to the heating device, the parecoxib sodium solution flowing in the annular gap is heated, the purpose of increasing the temperature of the parecoxib sodium solution is achieved, crystal precipitation is reduced or avoided, and the production efficiency is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of parecoxib sodium production, and more specifically, to a filtering device for filtering impurities in the synthesis process of parecoxib sodium. Background Art

[0002] Parecoxib sodium has a good analgesic effect, rapid onset, long-lasting effect, can effectively inhibit allodynia, has high gastrointestinal safety, and is mainly used clinically for short-term treatment of postoperative pain. It is one of the basic drugs for clinical multimodal analgesia. During the preparation of parecoxib sodium, multiple processes such as centrifugation and filtration are often required. Since activated carbon is added during the synthesis of parecoxib sodium to absorb impurities and endotoxins generated in the reaction, the parecoxib sodium solution needs to be filtered to remove the activated carbon particles that have absorbed impurities in the solution.

[0003] However, conventional filtration methods do not take into account the effect of temperature on solubility, resulting in a large change in the solubility of parecoxib sodium with temperature. When the temperature drops during the filtration process, crystals are easily precipitated, resulting in a decrease in yield. Utility Model Content

[0004] The utility model aims to provide a filtering device for filtering impurities in the synthesis process of parecoxib sodium, so as to solve the problems existing in the above-mentioned background technology.

[0005] The above technical objectives of the utility model are achieved through the following technical solutions:

[0006] The present application provides a filtering device for filtering impurities in the synthesis process of parecoxib sodium, comprising a delivery pipeline for delivering parecoxib sodium solution and a heat-conducting pipeline loaded with a heat-conducting medium, both ends of the delivery pipeline are opened, the heat-conducting pipeline is sleeved with the delivery pipeline, and the heat-conducting pipeline is located inside the delivery pipeline;

[0007] An annular filter channel is formed between the inner wall of the conveying pipe and the outer wall of the heat-conducting pipe. An annular filter element is provided in the annular filter channel for filtering the activated carbon particles in the conveyed parecoxib sodium solution, and the inner wall of the inner ring of the annular filter element abuts against the outer wall of the heat-conducting pipe, and the outer wall of the outer ring of the annular filter element abuts against the inner wall of the conveying pipe.

[0008] The beneficial effects of the utility model are as follows: in this scheme, a heat-conducting pipe loaded with a heat-conducting medium and a conveying pipe for conveying the parecoxib sodium solution are provided, and the heat-conducting pipe is located inside the conveying pipe, that is, when conveying the parecoxib sodium solution, the parecoxib sodium solution is conveyed through the annular gap between the inner wall of the conveying pipe and the outer wall of the heat-conducting pipe, and an annular filter is arranged in the annular gap, thereby achieving the purpose of filtering the parecoxib sodium solution; since the inside of the heat-conducting pipe is filled with a heat-conducting medium, which can be heat-conducting oil, water, etc.; the heat of the heat-conducting medium will be dissipated through the outer wall of the heat-conducting pipe, so as to heat the parecoxib sodium solution flowing in the annular gap, so as to achieve the purpose of increasing the temperature of the parecoxib sodium solution, reduce or avoid crystal precipitation, and improve production efficiency.

[0009] In this scheme, the parecoxib sodium solution passes through the annular gap between the inner wall of the conveying pipe and the outer wall of the heat-conducting pipe, and the heat-conducting pipe is filled with a heat-conducting medium of a certain temperature, so that the heat dissipated by the heat-conducting pipe is uniform in the circumferential direction; the parecoxib sodium solution passes through the annular gap, and because the width of the annular gap is much smaller than the diameter of the conveying pipe, this can avoid the problem that when the pipe for conveying the parecoxib sodium solution is large, the solution in the middle of the pipe cannot be effectively heated, thereby making the heating effect of the parecoxib sodium solution better, more comprehensive, and more uniform.

[0010] On the basis of the above technical solution, the present invention can also be improved as follows.

[0011] Furthermore, the heat transfer pipe is connected to a circulation pipeline, the two ends of the circulation pipeline are respectively connected to the two ends of the heat transfer pipe, and the interior of the circulation pipeline is connected to the interior of the heat transfer pipe; a heater and a delivery pump are also provided in the circulation pipeline.

[0012] The beneficial effect of adopting the above further scheme is: the advantage is that the heat-conducting medium can be heated by the heater to keep the temperature of the heat-conducting medium at a constant temperature; the purpose of the delivery pump is to circulate the heat-conducting medium in the heat-conducting pipe and the circulation pipeline.

[0013] Furthermore, the two open ends of the delivery pipeline respectively form a liquid inlet and a liquid outlet, and the liquid inlet and the liquid outlet are respectively arranged upward and downward.

[0014] The beneficial effect of adopting the above further solution is: such an advantage makes liquid inlet and liquid discharge convenient.

[0015] Furthermore, the liquid inlet and the liquid outlet are both penetrated by a plug hole, the circulation pipeline extends from the inside of the delivery pipeline through the plug hole to the outside of the delivery pipeline, and the heater and the delivery pump are located outside the delivery pipeline.

[0016] The beneficial effect of adopting the above further solution is that the installation of the overall device is more reasonable and the influence on the heater and the delivery pump is avoided.

[0017] Furthermore, the annular filter element is connected to the delivery pipe and the heat transfer pipe, and the circulation pipeline is connected to the liquid outlet and the liquid inlet via sealing elements.

[0018] The beneficial effect of adopting the above further solution is: improving the sealing between the annular filter and the conveying pipeline and the heat transfer pipeline, and between the circulation pipeline and the liquid outlet and the liquid inlet, thereby avoiding leakage of the parecoxib sodium solution.

[0019] Furthermore, the gaps between the inner wall of the delivery pipe and the outer wall of the heat-conducting pipe are evenly arranged.

[0020] The beneficial effect of adopting the above further solution is that the parecoxib sodium solution in the annular gap can be heated evenly.

[0021] Furthermore, the above also includes a mounting frame, which includes a support body and a fixing member, the fixing member is located on the upper end surface of the support body, and the fixing member sleeves the conveying pipeline.

[0022] The beneficial effect of adopting the above further solution is that the applicability of the overall device can be improved.

[0023] Furthermore, at least two of the above-mentioned fixing members and annular filtering members are provided.

[0024] The beneficial effect of adopting the above further solution is that it can improve the stability of the delivery pipeline and enhance the filtering effect of the parecoxib sodium solution.

[0025] Furthermore, a plurality of supporting feet are provided on the lower end surface of the supporting body, and the heater and the delivery pump are both located in the cavity formed by the supporting feet and the supporting body.

[0026] Furthermore, the height of the support leg near the liquid inlet is greater than the height of the support leg near the liquid outlet.

[0027] The beneficial effect of adopting the above further solution is that the entire conveying pipeline is tilted, that is, one end of the liquid inlet is tilted toward one end of the liquid outlet, so that the parecoxib sodium solution is easy to flow in the annular gap.

[0028] Compared with the prior art, the utility model has at least the following beneficial effects:

[0029] In the present application, a heat-conducting pipe loaded with a heat-conducting medium and a conveying pipe for conveying a parecoxib sodium solution are provided, and the heat-conducting pipe is located inside the conveying pipe, that is, when conveying the parecoxib sodium solution, it is conveyed through the annular gap between the inner wall of the conveying pipe and the outer wall of the heat-conducting pipe, and then an annular filter element is arranged in the annular gap, thereby achieving the purpose of filtering the parecoxib sodium solution; since the inside of the heat-conducting pipe is filled with a heat-conducting medium, which can be heat-conducting oil, water, etc.; the heat of the heat-conducting medium will be dissipated through the outer wall of the heat-conducting pipe to heat the parecoxib sodium solution flowing in the annular gap, so as to achieve the purpose of increasing the temperature of the parecoxib sodium solution, reduce or avoid crystal precipitation, and improve production efficiency.

[0030] In the present application, the parecoxib sodium solution passes through the annular gap between the inner wall of the conveying pipe and the outer wall of the heat-conducting pipe, and the heat-conducting pipe is filled with a heat-conducting medium of a certain temperature, so that the heat dissipated by the heat-conducting pipe is uniform in the circumferential direction; the parecoxib sodium solution passes through the annular gap, and because the width of the annular gap is much smaller than the diameter of the conveying pipe, this can avoid the problem that when the pipe for conveying the parecoxib sodium solution is large, the solution in the middle of the pipe cannot be effectively heated, so that the heating effect of the parecoxib sodium solution is better, more comprehensive, and more uniform.

[0031] In the present application, the heater provided can heat the heat-conducting medium to keep the temperature of the heat-conducting medium at a constant temperature; the purpose of the delivery pump is to make the heat-conducting medium circulate in the heat-conducting pipe and the circulation pipeline; the annular filter element and the delivery pipeline and the heat-conducting pipe, as well as the circulation pipeline and the liquid outlet and the liquid inlet are connected by sealing members to improve the sealing performance and avoid leakage of the parecoxib sodium solution. The gap between the inner wall of the delivery pipeline and the outer wall of the heat-conducting pipe is evenly arranged so that the parecoxib sodium solution in the annular gap is evenly heated; the delivery pipeline is tilted as a whole, that is, one end of the liquid inlet is tilted toward one end of the liquid outlet, so as to facilitate the flow of the parecoxib sodium solution in the annular gap. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] The drawings described herein are used to provide a further understanding of the embodiments of the present utility model, constitute a part of this application, and do not constitute a limitation of the embodiments of the present utility model. In the drawings:

[0033] Figure 1 This is a schematic diagram of the connection between the delivery pipeline and the installation frame in the embodiment of the utility model;

[0034] Figure 2 This is a schematic diagram of the structure of the mounting frame in the embodiment of the utility model;

[0035] Figure 3This is a schematic diagram of the connection between the heat transfer pipe and the circulation pipe in the embodiment of the utility model;

[0036] Figure 4 This is a schematic diagram of the sleeve connection of the heat transfer pipe and the delivery pipe in the embodiment of the utility model;

[0037] Figure 5 It is a schematic vertical cross-sectional view of the heat transfer pipe and the delivery pipe in the embodiment of the utility model.

[0038] Marks and corresponding parts names in the drawings;

[0039] 1. Conveying pipeline; 2. Heat transfer pipeline; 3. Annular filter channel; 4. Annular filter element; 5. Circulating pipeline; 6. Heater; 7. Conveying pump; 8. Liquid inlet; 9. Liquid outlet; 10. Mounting frame; 11. Support body; 12. Fixing part; 13. Support foot. DETAILED DESCRIPTION

[0040] In order to make the purpose, technical scheme and advantages of the embodiments of the utility model clearer, the technical scheme in the embodiments of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiments of the utility model. Obviously, the described embodiments are part of the embodiments of the utility model, not all of the embodiments. Generally, the components of the embodiments of the utility model described and shown in the drawings here can be arranged and designed in various different configurations.

[0041] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the present invention to be protected, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0042] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0043] In the description of the embodiments of the present utility model, it should be noted that if the terms "up", "down", "left", "right", "vertical", "horizontal", "inside", "outside", etc. appear, the orientation or position relationship indicated is based on the orientation or position relationship shown in the accompanying drawings, or is the orientation or position relationship in which the utility model product is usually placed when used. It is only for the convenience of describing the utility model and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present utility model.

[0044] In addition, the terms "horizontal", "vertical", "overhanging" and the like do not mean that the components must be absolutely horizontal or overhanging, but can be slightly tilted. For example, "horizontal" only means that its direction is more horizontal than "vertical", and does not mean that the structure must be completely horizontal, but can be slightly tilted.

[0045] In the description of the embodiments of the present invention, "multiple" means at least 2.

[0046] In the description of the embodiments of the present utility model, it is also necessary to explain that, unless otherwise clearly specified and limited, the terms "set", "install", "connect", and "connect" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present utility model can be understood according to specific circumstances.

[0047] Embodiment 1:

[0048] In order to avoid the problem that the temperature is lowered during the filtration of the parecoxib sodium solution, which is easy to precipitate crystals and leads to a decrease in yield, the present embodiment provides a filtering device for filtering impurities in the synthesis process of parecoxib sodium, including a conveying pipeline 1 for conveying the parecoxib sodium solution and a heat-conducting pipeline 2 loaded with a heat-conducting medium. The conveying pipeline 1 and the heat-conducting pipeline 2 can be made of metal materials, such as metal copper, and the cross-sections of the two can be circular, such as Figure 1 and Figure 4 As shown, both ends of the conveying pipeline 1 are opened, the heat-conducting pipeline 2 is sleeved with the conveying pipeline 1, and the heat-conducting pipeline 2 is located inside the conveying pipeline 1.

[0049] Among them, there is a heat-conducting pipe 2 loaded with a heat-conducting medium and a conveying pipe 1 for conveying the parecoxib sodium solution, and the heat-conducting pipe 2 is located inside the conveying pipe 1, that is, when conveying the parecoxib sodium solution, it is conveyed through the annular gap between the inner wall of the conveying pipe 1 and the outer wall of the heat-conducting pipe 2, and then an annular filter element 4 is arranged in the annular gap, thereby achieving the purpose of filtering the parecoxib sodium solution; since the heat-conducting pipe 2 is filled with a heat-conducting medium, the heat-conducting medium in this embodiment is heat-conducting oil; the heat of the heat-conducting medium will be dissipated through the outer wall of the heat-conducting pipe 2 to achieve heating of the parecoxib sodium solution flowing in the annular gap.

[0050] Furthermore, an annular filter channel 3 is formed between the inner wall of the conveying pipe 1 and the outer wall of the heat-conducting pipe 2. An annular filter element 4 for filtering activated carbon particles in the conveyed parecoxib sodium solution is provided in the annular filter channel 3. The annular filter element 4 can filter the activated carbon in the solution, which is relatively common for those skilled in the art and will not be described in detail here; the inner wall of the inner ring of the annular filter element 4 abuts against the outer wall of the heat-conducting pipe 2, and the outer wall of the outer ring of the annular filter element 4 abuts against the inner wall of the conveying pipe 1.

[0051] Among them, the parecoxib sodium solution passes through the annular filter channel 3 between the inner wall of the conveying pipe 1 and the outer wall of the heat-conducting pipe 2, the heat-conducting pipe 2 is filled with a heat-conducting medium of a certain temperature, and the heat-conducting pipe 2 seals the heat-conducting medium; in this way, for the heat dissipated by the heat-conducting pipe 2, the heat dissipated in the circumferential direction is uniform; the parecoxib sodium solution passes through the annular filter channel 3, and since the width of the annular filter channel 3 is much smaller than the diameter of the conveying pipe 1, this can avoid the problem that when the pipe for conveying the parecoxib sodium solution is large, the solution in the middle of the pipe cannot be effectively heated, so that the heating effect of the parecoxib sodium solution is better, more comprehensive, and more uniform.

[0052] Embodiment 2:

[0053] The embodiment of the present application provides a structure for heating a heat-conducting medium, wherein a heat-conducting pipe 2 is connected to a circulation pipe 5, two ends of the circulation pipe 5 are respectively connected to two ends of the heat-conducting pipe 2, and the interior of the circulation pipe is connected to the interior of the heat-conducting pipe 2; a heater 6 and a delivery pump 7 are also provided in the circulation pipe 5.

[0054] The heat-conducting medium is heated by the heater 6 so that the temperature of the heat-conducting medium can be kept at a constant temperature, and the purpose of the delivery pump 7 is to circulate the heat-conducting medium in the heat-conducting pipe 2 and the circulation pipeline 5 .

[0055] Further, on the basis of setting the circulation pipeline 5, the heater 6 and the delivery pump 7, a liquid inlet 8 and a liquid outlet 9 can be respectively set at both ends of the delivery pipeline 1, such as Figure 1 As shown, the two open ends of the delivery pipeline 1 respectively form a liquid inlet 8 and a liquid outlet 9, and the liquid inlet 8 and the liquid outlet 9 are respectively arranged upward and downward; this makes liquid intake and discharge convenient.

[0056] Optionally, after the circulation pipeline 5 is provided, since the circulation pipeline 5 needs to be extended outside the delivery pipeline 1, it is necessary to provide through holes at the liquid inlet 8 and the liquid outlet 9, such as Figure 1 As shown, the liquid inlet 8 and the liquid outlet 9 are both penetrated by a plug hole, the circulation pipeline extends from the inside of the delivery pipeline 1 through the plug hole to the outside of the delivery pipeline 1, and the heater 6 and the delivery pump 7 are located outside the delivery pipeline 1.

[0057] Among them, after the jack is set, the other part of the circulation pipeline 5 can be extended to the outside of the delivery pipeline 1. The connection diagram of the circulation pipeline 5 and the heat transfer pipeline 2 is as shown in FIG. Figure 3 As shown, the installation of the overall device can be made more reasonable and the influence on the heater 6 and the delivery pump 7 can be avoided.

[0058] Specifically, in order to improve the sealing performance between the annular filter element 4 and the delivery pipe 1 and the heat transfer pipe 2, and between the circulation pipeline 5 and the liquid outlet 9 and the liquid inlet 8, and to avoid leakage of the parecoxib sodium solution, a seal can be provided at the connection, and the seal can be a sealing glue or the like.

[0059] Optionally, the annular filter element 4 and the delivery pipe 1 and the heat transfer pipe 2 , as well as the circulation pipeline 5 and the liquid outlet 9 and the liquid inlet 8 are all connected via sealing elements.

[0060] Optionally, the gap between the inner wall of the delivery pipe 1 and the outer wall of the heat-conducting pipe 2 is evenly arranged.

[0061] Among them, the evenly arranged annular filter channels 3 can make the parecoxib sodium solution flowing through the annular filter channels 3 be evenly heated, so as to achieve a better heating effect and avoid the situation where part of the solution is heated ineffectively.

[0062] Embodiment 3:

[0063] In order to make the overall structure of the delivery pipeline 1, the circulation pipeline 5, the heater 6 and the delivery pump 7 more compact, the delivery pipeline 1 can be installed through the mounting frame 10. In this embodiment, a mounting frame 10 is provided, and the mounting frame 10 includes a support body 11 and a fixing member 12. The fixing member 12 is located on the upper end surface of the support body 11, and the fixing member 12 sleeves the delivery pipeline 1.

[0064] The presence of the mounting frame 10 can make the overall structure uncluttered, such as Figure 1 and Figure 2 As shown, this can improve the practicality of the overall device.

[0065] Optionally, at least two of the fixing member 12 and the annular filter member 4 are provided. Figure 1 and Figure 5 As shown, at least two fixing members 12 can improve the stability of the delivery pipeline 1, and at least two annular filter members 4 can enhance the filtering effect of the parecoxib sodium solution.

[0066] Optionally, the lower end surface of the support body 11 is also provided with a plurality of legs 13, and the heater 6 and the delivery pump 7 are both located in the cavity formed by the legs 13 and the support body 11; and the height of the legs 13 near the liquid inlet 8 is greater than the height of the legs 13 near the liquid outlet 9.

[0067] Among them, the support legs 13 can form a cavity with the lower end surface of the support body 11. The heater 6 and the delivery pump 7 are located outside the delivery pipe 1, and can be placed in this cavity to reasonably improve the space utilization rate; specifically, the inclined delivery pipe 1 can make the solution flow from one end of the liquid inlet 8 to one end of the liquid outlet 9 with gravity, thereby improving the filtration efficiency to a certain extent.

[0068] The specific implementation methods described above further illustrate the purpose, technical solutions and beneficial effects of the utility model in detail. It should be understood that the above description is only the specific implementation method of the utility model and is not used to limit the protection scope of the utility model. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the utility model should be included in the protection scope of the utility model.

Claims

1. A filtering device for filtering impurities in the synthesis process of parecoxib sodium, characterized in that: It comprises a delivery pipeline for delivering parecoxib sodium solution and a heat-conducting pipeline loaded with a heat-conducting medium, both ends of the delivery pipeline are opened, the heat-conducting pipeline is sleeved with the delivery pipeline, and the heat-conducting pipeline is located inside the delivery pipeline; An annular filter channel is formed between the inner wall of the conveying pipe and the outer wall of the heat-conducting pipe. An annular filter element is provided in the annular filter channel for filtering activated carbon particles in the conveyed parecoxib sodium solution, and the inner wall of the inner ring of the annular filter element abuts against the outer wall of the heat-conducting pipe, and the outer wall of the outer ring of the annular filter element abuts against the inner wall of the conveying pipe.

2. A filtering device for filtering impurities in the synthesis process of parecoxib sodium according to claim 1, characterized in that: The heat transfer pipe is connected to a circulation pipeline, the two ends of the circulation pipeline are respectively connected to the two ends of the heat transfer pipe, and the interior of the circulation pipeline is communicated with the interior of the heat transfer pipe; a heater and a delivery pump are also arranged in the circulation pipeline.

3. A filtering device for filtering impurities in the synthesis process of parecoxib sodium according to claim 2, characterized in that: The two open ends of the delivery pipeline respectively form a liquid inlet and a liquid outlet, and the liquid inlet and the liquid outlet are respectively arranged upward and downward.

4. A filtering device for filtering impurities in the synthesis process of parecoxib sodium according to claim 3, characterized in that: The liquid inlet and the liquid outlet are both penetrated by a plug hole, the circulation pipeline extends from the inside of the delivery pipeline through the plug hole to the outside of the delivery pipeline, and the heater and the delivery pump are located outside the delivery pipeline.

5. A filtering device for filtering impurities in the synthesis process of parecoxib sodium according to claim 4, characterized in that: The annular filter element is connected to the delivery pipeline and the heat-conducting pipeline, and the circulation pipeline is connected to the liquid outlet and the liquid inlet through sealing elements.

6. A filtering device for filtering impurities in the synthesis process of parecoxib sodium according to claim 1, characterized in that: The gaps between the inner wall of the delivery pipe and the outer wall of the heat conduction pipe are evenly arranged.

7. A filtering device for filtering impurities in the synthesis process of parecoxib sodium according to claim 3, characterized in that: It also includes a mounting frame, which includes a support body and a fixing member. The fixing member is located on the upper end surface of the support body, and the fixing member sleeves the conveying pipeline.

8. A filtering device for filtering impurities in the synthesis process of parecoxib sodium according to claim 7, characterized in that: At least two of the fixing element and the annular filter element are provided.

9. A filtering device for filtering impurities in the synthesis process of parecoxib sodium according to claim 7, characterized in that: The lower end surface of the support body is also provided with a plurality of supporting feet, and the heater and the delivery pump are both located in a cavity formed by the supporting feet and the support body.

10. A filtering device for filtering impurities in the synthesis process of parecoxib sodium according to claim 9, characterized in that: The height of the support leg close to the liquid inlet is greater than the height of the support leg close to the liquid outlet.

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