Integrated valve group of FISH (fluorescence in situ hybridization) equipment

Abstract

The utility model relates to an FISH (fluorescence in situ hybridization) equipment integrated valve group, which comprises a shell, a liquid outlet, a connecting cylinder, a rectangular hole and a threaded hole, and the shell comprises a main shell, a rectangular cavity, a liquid outlet hole and a threaded hole; the plugging block is arranged at the bottom end of the main shell; the electromagnetic block is arranged outside the connecting cylinder through a threaded fixing block; the movable column is arranged in the rectangular cavity; the permanent magnet is arranged outside the movable column and located in the rectangular hole; the sealing square block is arranged in the rectangular cavity; and the reset spring is arranged in the rectangular cavity. Through the arrangement of the liquid outlet holes, the communicating holes and the liquid guide holes, when the movable column moves, the communicating holes move to the liquid outlet holes at different positions, so that the effect of conveying different medicaments is achieved, when an FISH method is used, output of two medicaments can be controlled through one electromagnetic valve, the electromagnetic valves are integrated through the integrated valve set, and the integrated valve set is convenient to use. And negative effects caused by pipeline connection are avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of medical in vitro diagnostic instrument related equipment, in particular to a FISH equipment integrated valve group. Background Art

[0002] Conventional paraffin-embedded tissue sections (conventional sections) are the most widely used method in conventional histological section preparation techniques. In pathology, they are often used to study, observe and judge the morphological changes of cell tissues. In combination with immunological techniques, they can be used for qualitative and localized observation and research of macromolecular substances such as polypeptides and proteins in cell tissues in tissue sections. In combination with FISH methods (fluorescence in situ hybridization), they can be used for gene localization and status analysis in cells. They are currently widely used in research in multidisciplinary fields.

[0003] In conventional FISH testing, paraffin-embedded tissue sections need to be processed through steps such as dewaxing, penetrant penetration, pepsin digestion, cleaning, draining, and waste liquid removal. This process involves the switching of multiple reagents, and the switching of each reagent requires a corresponding solenoid valve for control. Valves often require a large number of pipes to be connected to each other, which causes unreliable connections and increased maintenance difficulty. In addition, a large number of pipe connections will occupy a large space, resulting in reduced space utilization. Therefore, a FISH equipment integrated valve group is proposed to solve the above-mentioned problems. Utility Model Content

[0004] Based on the above description, the utility model provides an integrated valve group for FISH equipment to solve the problem that too many pipes between solenoid valves in the FISH method lead to greater maintenance difficulty and larger occupied space.

[0005] The utility model provides a technical solution to the above-mentioned technical problems as follows: a FISH device integrated valve group, comprising: a shell, the shell comprising a main shell, a rectangular cavity, a liquid outlet, a connecting tube, a rectangular hole and a threaded hole, a blocking block is arranged at the bottom end of the main shell, an electromagnetic block is arranged on the outside of the connecting tube through a threaded fixing block, and comprises an electromagnetic coil, a movable column is arranged inside the rectangular cavity, and comprises a connecting hole, a permanent magnet is arranged on the outside of the movable column through a fixing nut, and is located inside the rectangular hole, a sealing block is arranged inside the rectangular cavity, and a reset spring is arranged inside the rectangular cavity and contacts the movable column.

[0006] On the basis of the above technical solution, the present invention can also be improved as follows.

[0007] Furthermore, a rectangular cavity is arranged inside the main shell, and a liquid outlet is arranged on the outer surface of the main shell, and the liquid outlet is communicated with the rectangular cavity.

[0008] Furthermore, a connecting tube is provided at the top end of the main shell, and threaded holes and rectangular holes are provided in sequence inside the connecting tube from top to bottom, and the rectangular hole is communicated with the rectangular cavity.

[0009] Furthermore, the blocking block includes a bottom plate, and the bottom plate is arranged on the bottom end of the main shell by screws.

[0010] Furthermore, a rectangular block is provided on the upper surface of the bottom plate, and the rectangular block extends into the interior of the rectangular cavity.

[0011] Furthermore, the electromagnetic block includes a coil housing, and two electromagnetic coils are arranged inside the coil housing.

[0012] Furthermore, the movable column includes a column body, the outer surface of the column body is provided with a connecting hole, and the upper and lower sides of the column body are both provided with return springs in contact with the shell.

[0013] Furthermore, a connecting rod and a threaded rod are sequentially arranged at the top of the column from bottom to top, and a permanent magnet is arranged outside the threaded rod via a fixing nut.

[0014] Furthermore, the sealing block includes a first block, a second block is arranged between the first blocks, a liquid guide hole is arranged on the outer surface of the second block, and the liquid guide hole is communicated with the liquid outlet hole.

[0015] Furthermore, a third block is arranged between the second blocks, and adjacent surfaces of the first block, the second block and the third block are all provided with annular grooves, and a sealing ring is arranged inside the annular groove, and the sealing ring contacts the outer surface of the column.

[0016] Compared with the prior art, the technical solution of this application has the following beneficial technical effects:

[0017] 1. The utility model sets two electromagnetic coils and permanent magnets and other components. Through the cooperation of the electromagnetic coils and the permanent magnets and other components, when only the electromagnetic coil located at the top is energized, the permanent magnet drives the movable column to move upward, and when only the electromagnetic coil located at the bottom is energized, the permanent magnet drives the movable column to move downward, thereby achieving the effect of adjusting the position of the movable column;

[0018] 2. By setting the liquid outlet hole, the connecting hole and the liquid guide hole, when the movable column moves, the connecting hole moves to the liquid outlet hole at different positions to achieve the effect of delivering different agents. When using the FISH method, the output of two agents can be controlled by one solenoid valve, and the integrated valve group integrates the solenoid valve to avoid the negative impact of pipeline connection. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 A schematic diagram of the structure of an integrated valve group for a FISH device provided in an embodiment of the utility model;

[0020] Figure 2 for Figure 1 A structural diagram from another perspective;

[0021] Figure 3 for Figure 1 Structural cross-sectional view of

[0022] Figure 4 for Figure 3 A structural diagram from another perspective;

[0023] Figure 5 for Figure 4 A partial enlarged schematic diagram of the middle A area;

[0024] Figure 6 This is a structural cross-sectional view of the housing in the embodiment of the utility model;

[0025] Figure 7 This is a schematic diagram of the structure of the blocking block in the embodiment of the utility model;

[0026] Figure 8 This is a schematic diagram of the structure of the movable column in the embodiment of the utility model;

[0027] Fig. 9 This is a schematic diagram of the structure explosion of the sealing block in the embodiment of the utility model;

[0028] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0029] 1. Shell; 11. Main shell; 12. Rectangular cavity; 13. Liquid outlet; 14. Connecting tube; 15. Rectangular hole; 16. Threaded hole; 2. Blocking block; 21. Bottom plate; 22. Rectangular blocking block; 3. Electromagnetic block; 31. Coil shell; 32. Electromagnetic coil; 4. Threaded fixing block; 5. Movable column; 51. Column; 52. Connecting hole; 53. Connecting rod; 54. Threaded rod; 6. Sealing block; 61. First block; 62. Second block; 63. Third block; 64. Annular groove; 65. Liquid guide hole; 7. Sealing ring; 8. Reset spring; 9. Permanent magnet; 10. Fixing nut. DETAILED DESCRIPTION

[0030] In order to facilitate understanding of the present application, the present application will be described more fully below with reference to the relevant drawings. Embodiments of the present application are provided in the drawings. However, the present application can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present application more thorough and comprehensive.

[0031] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used herein in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application.

[0032] When used herein, the singular forms "a", "an", and "said / the" may also include plural forms, unless the context clearly indicates otherwise. It should also be understood that the terms "include / comprise" or "have" etc. specify the presence of stated features, wholes, steps, operations, components, parts or combinations thereof, but do not exclude the possibility of the presence or addition of one or more other features, wholes, steps, operations, components, parts or combinations thereof.

[0033] See also Figure 1 , Figure 6 and Figure 7 , a FISH device integrated valve group, comprising:

[0034] The housing 1 comprises a main housing 11, a rectangular cavity 12, a liquid outlet hole 13, a connecting tube 14, a rectangular hole 15 and a threaded hole 16. The main housing 11 is provided with a rectangular cavity 12 inside, and the outer surface of the main housing 11 is provided with a liquid outlet hole 13, and the liquid outlet hole 13 is communicated with the rectangular cavity 12. The top of the main housing 11 is provided with a connecting tube 14, and the inside of the connecting tube 14 is provided with a threaded hole 16 and a rectangular hole 15 from top to bottom in sequence, and the rectangular hole 15 is communicated with the rectangular cavity 12.

[0035] A blocking block 2 is disposed at the bottom end of the main housing 11, and the blocking block 2 includes a bottom plate 21, and the bottom plate 21 is disposed at the bottom end of the main housing 11 by screws, and a rectangular blocking block 22 is disposed on the upper surface of the bottom plate 21, and the rectangular blocking block 22 extends to the inside of the rectangular cavity 12;

[0036] Based on the above, the outer shell 1 and the sealing block 2 form a complete valve group outer shell, wherein the rectangular hole 12 provides an installation space for the movable column 5, the sealing block 6 and the return spring 8. The rectangular hole 12 restricts the sealing block 6, so that the liquid outlet hole 13 and the liquid guide hole 65 are interconnected. The setting of the rectangular hole 15 restricts the movable column 5 and the permanent magnet 9, so that the movable column 5 and the permanent magnet 9 can only move vertically.

[0037] like Figure 3-Figure 5 As shown, the electromagnetic block 3 is arranged outside the connecting cylinder 14 through a threaded fixing block 4 and includes an electromagnetic coil 32. The electromagnetic block 3 includes a coil housing 31, and two electromagnetic coils 32 are arranged inside the coil housing 31;

[0038] A permanent magnet 9, which is arranged outside the movable column 5 through a fixing nut 10 and is located inside the rectangular hole 15;

[0039] Based on the above, the electromagnetic block 3 plays a role in generating magnetic force and attracting the permanent magnet 9 to move. At this time, the two electromagnetic coils 32 and the permanent magnet 9 have the same magnetic pole direction. Figure 5 For example, when the electromagnetic coil 32 generates magnetic force after being energized, the upper magnetic pole is the N pole. At this time, the magnetic pole above the permanent magnet 9 also needs to be the N pole. If the electromagnetic coil 32 is energized, the upper magnetic pole is the S pole, then the magnetic pole above the permanent magnet 9 also needs to be the S pole. When the directions of the magnetic poles are consistent, the directions of the magnetic poles on one side adjacent to the electromagnetic coil 32 and the permanent magnet 9 are opposite, and the opposite magnetic poles generate attraction, thereby achieving the effect of attracting the permanent magnet 9 to move.

[0040] like Figure 3 , Figure 4 , Figure 8 and Fig. 9 As shown, the movable column 5 is arranged inside the rectangular cavity 12 and includes a connecting hole 52. The movable column 5 includes a column 51. The outer surface of the column 51 is provided with a connecting hole 52. The upper and lower sides of the column 51 are provided with a reset spring 8 in contact with the housing 1. The top of the column 51 is provided with a connecting rod 53 and a threaded rod 54 in sequence from bottom to top. The outside of the threaded rod 54 is provided with a permanent magnet 9 through a fixing nut 10.

[0041] a return spring 8, which is disposed inside the rectangular cavity 12 and in contact with the movable column 5;

[0042] Based on the above, after the movable column 5 and the permanent magnet 9 are connected to each other, the movable column 5 can move vertically under the drive of the permanent magnet 9, and the reset spring 8 is squeezed during the movement, so that the reset spring 8 generates elastic force, and then when the electromagnetic block 3 is not energized, the movable column 5 can return to the initial position under the action of the elastic force, that is, Figure 3 The position in.

[0043] A sealing block 6 is arranged inside the rectangular cavity 12, the sealing block 6 comprises a first block 61, a second block 62 is arranged between the first blocks 61, a liquid guide hole 65 is arranged on the outer surface of the second block 62, the liquid guide hole 65 is communicated with the liquid outlet hole 13, a third block 63 is arranged between the second blocks 62, an annular groove 64 is arranged on the adjacent surfaces of the first block 61, the second block 62 and the third block 63, a sealing ring 7 is arranged inside the annular groove 64, and the sealing ring 7 is in contact with the outer surface of the column 51;

[0044] Based on the above, the sealing block 6 and the sealing ring 7 cooperate with each other to play a sealing role. When the main body 51 moves upward or downward, the connecting hole 52 can only connect the liquid guide hole 65 and the liquid outlet hole 13 on one side. During the connection process, the sealing ring 7 plays a sealing role to prevent the liquid from flowing to other positions.

[0045] In actual use of this embodiment, the liquid outlet 13 on one side is connected to the pipeline for conveying reagents. The initial state of the device after connection is as follows: Figure 3 As shown, at this time, the communication hole 52 is not connected to the liquid guide hole 65, so the reagent cannot be discharged from the liquid outlet hole 13 on the other side through the valve group;

[0046] When the reagent needs to be discharged, the electromagnetic coil 32 at this location can be energized (the control method is a prior art, and the control method is not the main body of the technical solution, so the specific content is not repeated here). When only the electromagnetic coil 32 at the top is energized to generate magnetic force, since opposite magnetic poles will attract each other, the permanent magnet 9 drives the movable column 5 to move upward together under the action of suction. After the movement, the connecting hole 52 is connected with the liquid guide hole 65 and the liquid outlet hole 13 above. At this time, the reagent is discharged from the liquid outlet hole 13 above this location;

[0047] The principle is the same. When only the electromagnetic coil 32 at the bottom is energized to generate magnetic force, the movable column 5 moves downward, so that the reagent can be discharged from the liquid outlet 13 at the bottom. When the movable column 5 moves, it squeezes the reset spring 8, so that the reset spring 8 generates a reverse elastic force. When the electromagnetic coil 32 is short-circuited and loses its magnetic force, the movable column 5 returns to the position under the action of the elastic force. Figure 3 Status in

[0048] The device integrates multiple solenoid valves to reduce the pipe connections between the solenoid valves, which not only increases the overall reliability, but also avoids the situation of too messy pipes and inconvenience in maintenance. In addition, without complicated pipes, the valve group occupies a smaller space.

[0049] In addition, the device adopts a unique solenoid valve structure, so that the same solenoid valve can control the outflow of two different reagents. Compared with the traditional two-position three-way solenoid valve, this solenoid valve has the function of controlling the reagent from flowing out, that is, there are three states: the upper reagent flows out, the lower reagent flows out, and both reagents do not flow out. The above three states are more in line with the actual needs of the FISH method.

[0050] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A FISH equipment integrated valve group, characterized in that: include: The housing (1) comprises a main housing (11), a rectangular cavity (12), a liquid outlet (13), a connecting tube (14), a rectangular hole (15) and a threaded hole (16); A blocking block (2) disposed at the bottom end of the main housing (11); An electromagnetic block (3) which is arranged outside the connecting tube (14) via a threaded fixing block (4) and comprises an electromagnetic coil (32); A movable column (5) disposed inside the rectangular cavity (12) and comprising a communication hole (52); A permanent magnet (9) is arranged on the outside of the movable column (5) through a fixing nut (10) and is located inside the rectangular hole (15); A sealing block (6) disposed inside the rectangular cavity (12); A return spring (8) is arranged inside the rectangular cavity (12) and is in contact with the movable column (5).

2. The FISH device integrated valve group according to claim 1, characterized in that: A rectangular cavity (12) is provided inside the main shell (11), and a liquid outlet hole (13) is provided on the outer surface of the main shell (11); the liquid outlet hole (13) and the rectangular cavity (12) are communicated with each other.

3. The FISH device integrated valve group according to claim 2, characterized in that: A connecting tube (14) is provided at the top end of the main shell (11), and a threaded hole (16) and a rectangular hole (15) are provided inside the connecting tube (14) in sequence from top to bottom, and the rectangular hole (15) is connected to the rectangular cavity (12).

4. The FISH device integrated valve group according to claim 1, characterized in that: The blocking block (2) comprises a bottom plate (21), and the bottom plate (21) is arranged on the bottom end of the main housing (11) by means of screws.

5. The FISH device integrated valve group according to claim 4, characterized in that: A rectangular block (22) is provided on the upper surface of the bottom plate (21), and the rectangular block (22) extends into the interior of the rectangular cavity (12).

6. The FISH device integrated valve group according to claim 1, characterized in that: The electromagnetic block (3) comprises a coil housing (31), and two electromagnetic coils (32) are arranged inside the coil housing (31).

7. The FISH device integrated valve group according to claim 1, characterized in that: The movable column (5) comprises a column (51), the outer surface of which is provided with a connecting hole (52), and the upper and lower sides of the column (51) are both provided with a return spring (8) in contact with the housing (1).

8. The FISH device integrated valve group according to claim 7, characterized in that: The top of the column (51) is provided with a connecting rod (53) and a threaded rod (54) in sequence from bottom to top, and a permanent magnet (9) is provided on the outside of the threaded rod (54) via a fixing nut (10).

9. The FISH device integrated valve group according to claim 8, characterized in that: The sealing block (6) comprises a first block (61), a second block (62) is arranged between the first blocks (61), a liquid guide hole (65) is arranged on the outer surface of the second block (62), and the liquid guide hole (65) is communicated with the liquid outlet hole (13).

10. The FISH device integrated valve group according to claim 9, characterized in that: A third block (63) is arranged between the second blocks (62); adjacent surfaces of the first block (61), the second block (62) and the third block (63) are all provided with annular grooves (64); a sealing ring (7) is arranged inside the annular groove (64); and the sealing ring (7) is in contact with the outer surface of the column (51).

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