Quantitative sampler for pharmacokinetic experiment

Abstract

The utility model discloses a quantitative sampler for pharmacokinetic experiments. The quantitative sampler comprises a base and a liquid pump, a support is arranged on the top face of the base, a main screw rod is rotationally connected to the top face of the support, a fixing frame is slidably connected to the interior of the support, the main screw rod is in threaded connection with a screw hole in the surface of the fixing frame, a liquid conveying pipe is installed on the bottom face of the fixing frame, and the liquid pump is installed on the top face in the support. A liquid inlet pipe of the liquid pump is connected with a liquid outlet of the liquid conveying pipe, a liquid outlet pipe of the liquid pump is connected with a liquid inlet of the liquid box, and an adjusting unit is arranged on the side face of the support. According to the quantitative sampler for the pharmacokinetics experiment, a plurality of sampling pipes can be conveniently placed by adopting the placing seat, meanwhile, the auxiliary linear motor drives the liquid box to quantitatively sample liquid medicine and put the liquid medicine into the sampling pipes, and the arranged flow meter can improve the accuracy of the amount of the liquid medicine.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmacokinetic experiments, in particular to a quantitative sampler for pharmacokinetic experiments. Background Art

[0002] Drug analysis is a discipline that uses chemical, physical, biological and microbiological methods and techniques to study the chemical testing of drugs, drug stability, bioavailability, drug clinical monitoring and the qualitative and quantitative analysis of the active ingredients of Chinese herbal medicines. It includes chemical testing of finished drugs, quality control of the drug production process, quality inspection of the drug storage process, clinical drug analysis, in vivo drug analysis, etc. During the analysis, a certain amount of drugs will be extracted as required to ensure the accuracy of the analysis.

[0003] The existing patent CN220084433U is a quantitative sampling device for drug analysis, which belongs to the field of drug sampling technology. The device includes a base, a support plate is arranged on one side of the base, a movable frame is arranged on one side of the support plate, a first sampling tube is arranged on the movable frame, and the two sides of the movable frame are threadedly connected to a limiting mechanism, and the limiting mechanism includes an adjusting screw, the adjusting screw is threadedly connected to the movable frame, and the end of the adjusting screw is rotatably connected to a limiting block, and the limiting block contacts the outer wall of the first sampling tube; the quantitative sampler needs to frequently disassemble and assemble the sampling tube during use, which affects the sampling efficiency and the sampling amount is prone to deviation. For this reason, a quantitative sampler for pharmacokinetic experiments is proposed. Utility Model Content

[0004] The technical problem to be solved by the utility model is to overcome the existing defects and provide a quantitative sampler for pharmacokinetic experiments. A placement seat is used to facilitate the placement of multiple sampling tubes. At the same time, the auxiliary linear motor drives the liquid tank to quantitatively sample the drug liquid into the sampling tube, and the flow meter provided can increase the accuracy of the drug liquid amount, which can effectively solve the problems in the background technology.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a quantitative sampler for pharmacokinetic experiments, comprising a base and a liquid pump;

[0006] The top surface of the base is provided with a bracket, the top surface of the bracket is rotatably connected with a main screw, the inside of the bracket is slidably connected with a fixing bracket, the main screw is threadedly connected with a screw hole on the surface of the fixing bracket, an infusion tube is installed on the bottom surface of the fixing bracket, the liquid pump is installed on the top surface inside the bracket, the liquid inlet pipe of the liquid pump is connected with the liquid outlet of the infusion tube, the liquid outlet pipe of the liquid pump is connected with the liquid inlet of the liquid tank, an adjustment unit is provided on the side of the bracket, and a fixing unit is provided on the top surface of the base;

[0007] Wherein, it also includes a controller, which is arranged on the front side of the top surface of the base, the input end of the liquid pump is electrically connected to the output end of the controller, and the input end of the controller is electrically connected to the output end of an external power supply.

[0008] The main screw is rotated to insert the infusion tube into the medicine container, and the liquid pump is started to transport the medicine liquid into the liquid tank for subsequent quantitative delivery.

[0009] Furthermore, the adjusting unit comprises an adjusting frame, a main linear motor, a connecting frame, a bolt, a placement seat, a support rod and a secondary linear motor, wherein there are two main linear motors and they are respectively fixed on the left and right sides of the frame, the front side of the main linear motor mover seat is connected to one end of the connecting frame, the outer side of the connecting frame is slidably connected with the adjusting frame, the front side of the adjusting frame is fixed with a placement seat, the screw hole in the front side of the placement seat is threadedly connected with a bolt, the secondary linear motor is fixed on the rear side of the top surface of the frame, the top surface of the secondary linear motor mover seat is provided with a support rod, the front side end of the support rod is connected to the rear side of the liquid tank, the input ends of the main linear motor and the secondary linear motor are electrically connected to the output end of the controller, the adjusting frames on the rear sides of the placement seats of a suitable number are slid to the suitable positions on the outer side of the connecting frame, the bolts are rotated to fix the sampling tube inside the placement seat, and the secondary linear motor is started to drive the liquid tank to move to quantitatively transport the liquid medicine to multiple sampling tubes.

[0010] Furthermore, the fixing unit includes a screw, a slide, a clamp and an anti-slip pad, the anti-slip pad is bonded to the middle of the top surface of the base, the slide has two slide grooves that are slidably connected to the side surfaces of the bracket, the screw hole inside the slide is threadedly connected to the screw, the inner end of the screw is rotatably connected to the outer side surface of the clamp, the slide slides in the slide groove to adjust the height of the clamp, the screw is rotated to allow the clamp to clamp and fix the drug container, and the anti-slip pad is used to increase the stability of the placement of the drug container.

[0011] Furthermore, it also includes a liquid level sensor and a flow meter, wherein the liquid level sensor is fixed on the top surface of the liquid tank, and the flow meter is installed on the liquid outlet pipe on the bottom surface of the liquid tank, and the output ends of the liquid level sensor and the flow meter are electrically connected to the input end of the controller. The liquid level sensor can detect the remaining amount of liquid medicine in the liquid tank, and the flow meter can detect the amount of liquid medicine delivered, so as to improve the accuracy of liquid medicine quantification to meet the needs of pharmacokinetic experiments.

[0012] Furthermore, it also includes a stabilizing pad and a limiting frame, wherein the limiting frames are fixed to the four corners of the top surface of the stabilizing pad, and the limiting frames are correspondingly plugged into the limiting grooves on the bottom surface of the base. The limiting frames are plugged into the limiting grooves to install the stabilizing pad, thereby increasing the stability of the base placement.

[0013] Furthermore, it also includes an alarm, which is fixed to the top of the side of the bracket. The input end of the alarm is electrically connected to the output end of the controller. The alarm can flash and alarm when deviation occurs in the sampling of the liquid medicine to facilitate personnel to check.

[0014] Compared with the prior art, the beneficial effects of the utility model are:

[0015] 1. Adjust the placement seat to a suitable position by sliding the adjustment frame on the outside of the connecting frame, turn the bolts to fix the sampling tube inside the placement seat, start the auxiliary linear motor to drive the liquid tank to move to quantitatively transport the liquid to multiple sampling tubes;

[0016] 2. The height of the clamp is adjusted by sliding the slide in the slide groove, and the screw is turned to clamp the drug container, and the anti-slip pad is used to increase the stability of the drug container.

[0017] 3. By starting the liquid pump to transport the drug solution into the liquid tank, the liquid level sensor can detect the remaining drug solution in the liquid tank, and the flow meter can detect the amount of drug solution transported, so as to improve the accuracy of drug solution quantification to meet the needs of pharmacokinetic experiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the three-dimensional structure of the utility model;

[0019] Figure 2 This is a schematic diagram of the structure of the adjustment unit of the utility model;

[0020] Figure 3 It is a partial enlarged structural schematic diagram of point A of the utility model.

[0021] In the figure: 1 base, 2 adjustment unit, 21 adjustment frame, 22 main linear motor, 23 connecting frame, 24 bolt, 25 placement seat, 26 support rod, 27 auxiliary linear motor, 3 fixing unit, 31 screw, 32 slide, 33 clamp, 34 anti-slip pad, 4 bracket, 5 main screw, 6 fixing frame, 7 infusion tube, 8 liquid pump, 9 liquid tank, 10 liquid level sensor, 11 flow meter, 12 stabilizing pad, 13 limit frame, 14 alarm, 15 controller. DETAILED DESCRIPTION

[0022] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0023] See also Figure 1-3 , this embodiment provides a quantitative sampler for pharmacokinetic experiments, including a base 1 and a liquid pump 8;

[0024] Among them, a bracket 4 is provided on the top surface of the base 1, a main screw 5 is rotatably connected to the top surface of the bracket 4, a fixing frame 6 is slidably connected inside the bracket 4, the main screw 5 is threadedly connected to the screw hole on the surface of the fixing frame 6, a liquid infusion tube 7 is installed on the bottom surface of the fixing frame 6, a liquid pump 8 is installed on the top surface inside the bracket 4, a liquid inlet pipe of the liquid pump 8 is connected to the liquid outlet of the liquid infusion pipe 7, and a liquid outlet pipe of the liquid pump 8 is connected to the liquid inlet of the liquid tank 9;

[0025] Among them, an adjustment unit 2 is provided on the side of the bracket 4, and the adjustment unit 2 includes an adjustment frame 21, a main linear motor 22, a connecting frame 23, a bolt 24, a placement seat 25, a support rod 26 and a secondary linear motor 27. There are two main linear motors 22 and they are respectively fixed on the left and right sides of the bracket 4. The front side of the main linear motor 22 mover seat is connected to one end of the connecting frame 23. The outer side of the connecting frame 23 is slidably connected with the adjustment frame 21. The front side of the adjustment frame 21 is fixed with a placement seat 25. The screw hole on the front side of the placement seat 25 is threadedly connected with the bolt 24. The linear motor 27 is fixed on the rear side of the top surface of the bracket 4, and the top surface of the mover seat of the auxiliary linear motor 27 is provided with a support rod 26. The front side end of the support rod 26 is connected to the rear side of the liquid tank 9. The input ends of the main linear motor 22 and the auxiliary linear motor 27 are electrically connected to the output end of the controller 15. The adjustment frame 21 on the rear side of the appropriate number of placement seats 25 is slid to a suitable position outside the connecting frame 23, and the bolt 24 is turned to fix the sampling tube inside the placement seat 25. The auxiliary linear motor 27 is started to drive the liquid tank 9 to move to quantitatively transport the liquid medicine to multiple sampling tubes.

[0026] The top surface of the base 1 is provided with a fixing unit 3, which includes a screw 31, a slide 32, a clamp 33 and an anti-skid pad 34. The anti-skid pad 34 is bonded to the middle of the top surface of the base 1. The slide 32 has two slide grooves that are respectively slidably connected to the side grooves of the bracket 4. The screw hole inside the slide 32 is threadedly connected to the screw 31. The inner end of the screw 31 is rotatably connected to the outer side of the clamp 33. The slide 32 slides in the slide groove to adjust the height of the clamp 33. The screw 31 is rotated to make the clamp 33 clamp and fix the drug container, and cooperate with the anti-skid pad 34 to increase the stability of the drug container.

[0027] The controller 15 is also included. The controller 15 is arranged on the front side of the top surface of the base 1. The input end of the liquid pump 8 is electrically connected to the output end of the controller 15. The input end of the controller 15 is electrically connected to the output end of the external power supply. The main screw 5 is rotated to insert the infusion tube 7 into the inside of the drug container, and the liquid pump 8 is started to transport the drug liquid to the inside of the liquid tank 9 for subsequent quantitative transportation.

[0028] The liquid level sensor 10 and the flow meter 11 are also included. The liquid level sensor 10 is fixed on the top surface of the liquid tank 9, and the flow meter 11 is installed on the liquid outlet pipe on the bottom surface of the liquid tank 9. The output ends of the liquid level sensor 10 and the flow meter 11 are electrically connected to the input end of the controller 15. The liquid level sensor 10 can detect the remaining amount of the liquid medicine in the liquid tank 9, and the flow meter 11 can detect the amount of liquid medicine delivered, so as to improve the accuracy of the quantitative determination of the liquid medicine to meet the requirements of pharmacokinetic experiments.

[0029] The base 1 also includes a stabilizing pad 12 and a limiting frame 13. The limiting frames 13 are fixed to the four corners of the top surface of the stabilizing pad 12. The limiting frames 13 are correspondingly plugged into the limiting grooves on the bottom surface of the base 1. The limiting frames 13 are plugged into the limiting grooves to install the stabilizing pad 12, thereby increasing the stability of the base 1.

[0030] It also includes an alarm 14, which is fixed to the top of the side of the bracket 4. The input end of the alarm 14 is electrically connected to the output end of the controller 15. The alarm 14 can flash an alarm when deviation occurs in the liquid medicine sampling to facilitate personnel to check.

[0031] The working principle of the utility model is as follows:

[0032] First, the limiting frame 13 is plugged into the limiting groove to install the stabilizing pad 12, thereby increasing the stability of the base 1. The medicine container is placed on the top surface of the anti-skid pad 34, and the slide 32 slides in the slide groove to adjust the height of the clamp 33. The screw 31 is rotated to make the clamp 33 clamp and fix the medicine container, and cooperate with the anti-skid pad 34 to increase the stability of the medicine container.

[0033] Then, slide the adjustment frame 21 on the rear side of an appropriate number of placement seats 25 to a suitable position on the outside of the connecting frame 23, turn the bolt 24 to fix the sampling tube inside the placement seat 25, turn the main screw 5 to insert the infusion tube 7 into the interior of the drug container, start the liquid pump 8 to transport the drug solution into the liquid tank 9, and at the same time start the auxiliary linear motor 27 to drive the liquid tank 9 to move to quantitatively transport the drug solution to multiple sampling tubes. The set liquid level sensor 10 can detect the remaining drug solution in the liquid tank 9, and the flow meter 11 can detect the amount of drug solution delivered to improve the accuracy of drug solution quantification to meet the needs of pharmacokinetic experiments.

[0034] It is worth noting that the controller 15 disclosed in the above embodiment uses the model S7-200, and the liquid level sensor 10 can be freely configured according to the actual application scenario. It is recommended to use the liquid level sensor of model MPM4700W, the flow meter 11 can use the flow meter of model DN65316L, and the alarm 14 can use the sound and light alarm of model KXB127-T. The controller 15 controls the main linear motor 22, the auxiliary linear motor 27, the liquid pump 8, the liquid level sensor 10, the flow meter 11 and the alarm 14 using the commonly used methods in the prior art.

[0035] The above description is only an embodiment of the present invention, and does not limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made by using the contents of the specification and drawings of the present invention, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A quantitative sampler for pharmacokinetic experiments, characterized in that: It comprises a base (1) and a liquid pump (8); The top surface of the base (1) is provided with a bracket (4), the top surface of the bracket (4) is rotatably connected with a main screw (5), the inside of the bracket (4) is slidably connected with a fixing frame (6), the main screw (5) is threadedly connected with a screw hole on the surface of the fixing frame (6), the bottom surface of the fixing frame (6) is installed with an infusion tube (7), the liquid pump (8) is installed on the top surface inside the bracket (4), the liquid inlet pipe of the liquid pump (8) is connected with the liquid outlet of the infusion tube (7), the liquid outlet pipe of the liquid pump (8) is connected with the liquid inlet of the liquid tank (9), the side surface of the bracket (4) is provided with an adjustment unit (2), and the top surface of the base (1) is provided with a fixing unit (3); It also includes a controller (15), which is arranged on the front side of the top surface of the base (1), the input end of the liquid pump (8) is electrically connected to the output end of the controller (15), and the input end of the controller (15) is electrically connected to the output end of an external power supply.

2. A quantitative sampler for pharmacokinetic experiments according to claim 1, characterized in that: The adjustment unit (2) comprises an adjustment frame (21), a main linear motor (22), a connecting frame (23), bolts (24), a placement seat (25), a support rod (26) and an auxiliary linear motor (27); the main linear motor (22) has two and is respectively fixed to the left and right sides of the bracket (4); the front side of the mover seat of the main linear motor (22) is connected to one end of the connecting frame (23); the outer side of the connecting frame (23) is slidably connected to the adjustment frame (21); the adjustment frame A placement seat (25) is fixed on the front side of the support (21), a bolt (24) is threadedly connected to the screw hole on the front side of the placement seat (25), the auxiliary linear motor (27) is fixed on the rear side of the top surface of the bracket (4), a support rod (26) is provided on the top surface of the mover seat of the auxiliary linear motor (27), the front side end of the support rod (26) is connected to the rear side of the liquid tank (9), and the input ends of the main linear motor (22) and the auxiliary linear motor (27) are electrically connected to the output end of the controller (15).

3. A quantitative sampler for pharmacokinetic experiments according to claim 1, characterized in that: The fixing unit (3) comprises a screw (31), a slide (32), a clamp (33) and an anti-skid pad (34); the anti-skid pad (34) is bonded to the middle of the top surface of the base (1); the slide (32) has two slide grooves that are respectively slidably connected to the side surfaces of the bracket (4); the screw hole inside the slide (32) is threadedly connected to the screw (31); the inner end of the screw (31) is rotatably connected to the outer side surface of the clamp (33).

4. A quantitative sampler for pharmacokinetic experiments according to claim 1, characterized in that: It also includes a liquid level sensor (10) and a flow meter (11), wherein the liquid level sensor (10) is fixed on the top surface of the liquid tank (9), and the flow meter (11) is installed on a liquid outlet pipe on the bottom surface of the liquid tank (9), and the output ends of the liquid level sensor (10) and the flow meter (11) are electrically connected to the input end of the controller (15).

5. A quantitative sampler for pharmacokinetic experiments according to claim 1, characterized in that: It also comprises a stabilizing pad (12) and a limiting frame (13), wherein the limiting frames (13) are fixed to the four corners of the top surface of the stabilizing pad (12), and the limiting frames (13) are correspondingly plugged into the limiting grooves on the bottom surface of the base (1).

6. A quantitative sampler for pharmacokinetic experiments according to claim 1, characterized in that: It also includes an alarm (14), which is fixed to the top end of the side of the bracket (4), and the input end of the alarm (14) is electrically connected to the output end of the controller (15).

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