Probe motion platform for nanopore sequencer

Abstract

The utility model relates to the technical field of medical sequencing auxiliary devices, in particular to a probe motion platform for a nanopore sequencer. Comprising a motion platform and a probe, the motion platform comprises a motion guide rail and an installation platform, the installation platform comprises a base, four positioning sensors are fixedly installed below the plane of the base, an installation shell is fixedly installed at the dead center of the base, and positioning grooves are symmetrically formed in the center of a circular ring at the bottom of the installation shell; the probe comprises a probe head and an installation part, the installation part comprises an integrally-formed shell, the shell comprises an upper bottom face and a lower bottom face, the centers of the upper bottom face and the lower bottom face are connected through a solid structure and provided with a sliding groove, a pressing part is inserted into the sliding groove and comprises a pressing handle, a stop block is arranged on the upper portion of the pressing handle, an insertion piece is integrally formed outside the stop block, and a positioning block is arranged on the upper portion of the stop block. By means of the structure, replacement of different types of probes can be achieved through simple single-hand operation, and the operation process is simpler and more convenient.

Description

Technical Field

[0001] This utility model patent relates to the technical field of medical sequencing auxiliary devices, and in particular to a probe motion platform for a nanopore sequencer. Background Art

[0002] A nanopore sequencer is a device that uses nanopore technology to perform single-molecule DNA sequencing. The probe and probe motion platform are important components of the nanopore sequencer, which are used to guide the DNA sample into the nanopore and control the movement of the DNA molecule in the nanopore. The probe is a slender tubular structure, usually made of silicon material, with extremely small size and high mechanical stability. Its shape and size can match the diameter of the nanopore, and by controlling the movement of the probe, the DNA molecule can be accurately guided into the nanopore. In addition, the probe can also stretch and relax the DNA molecule through electric field or pressure for sequencing.

[0003] The probes in the prior art are directly fixed and installed, or are inconvenient to disassemble and assemble, and cannot be completed with one hand. In actual operation, it is cumbersome and the operation efficiency is low. Therefore, it is necessary to develop a probe motion platform for nanopore sequencers, which can realize the replacement of different types of probes with simple one-handed operation, and the operation process is simpler. Summary of the invention

[0004] 1. Problems to be solved

[0005] It is mainly used to solve the problems in the prior art that the probe is directly fixed and installed, or it is inconvenient to disassemble and assemble, cannot be completed with one hand, is cumbersome in actual operation and has low operating efficiency, and provides a probe motion platform for a nanopore sequencer.

[0006] (II) Technical solution

[0007] The utility model discloses a probe motion platform for a nanopore sequencer, comprising a motion platform and a probe. The motion platform comprises a motion guide rail and a mounting platform. The mounting platform is slidably mounted below the motion guide rail. The mounting platform comprises a base. Four positioning sensors are fixedly mounted below the plane of the base. A mounting shell is fixedly mounted at the center of the base. The mounting shell is in a circular step shape, and a positioning groove is symmetrically provided at the center of the bottom circular ring. The probe comprises a probe head and a mounting part. The probe head is fixedly mounted at the bottom of the mounting part. The mounting part comprises an integrally formed shell. The shell comprises an upper and lower bottom surfaces. The centers of the upper and lower bottom surfaces are connected by a solid structure and are provided with a slide groove. A pressing part is inserted in the slide groove. The pressing part comprises a pressing handle. The upper part of the pressing handle is a stopper. An insert is integrally formed on the outside of the stopper. The insert is inserted in the slide groove. The upper part of the stopper is a positioning block. The positioning block matches the positioning groove. A spring is fixedly connected between the inside of the stopper and the upper end of the slide groove.

[0008] As a preferred technical solution, the motion guide rail includes a longitudinal guide rail and a transverse guide rail, and the longitudinal guide rail is slidably mounted on the transverse guide rail.

[0009] As a preferred technical solution, the motion guide rail is driven by a nanometer-scale micro motor.

[0010] As a preferred technical solution, the upper and lower bottom surfaces are in the shape of an "I" character.

[0011] As a preferred technical solution, the length of the positioning block is greater than the thickness of the inner wall of the circular ring of the mounting housing.

[0012] As a preferred technical solution, the edge of the stopper is slightly wider than the minimum circular ring diameter at the bottom of the mounting housing.

[0013] As a preferred technical solution, the probe is installed at the center of the installation part.

[0014] (III) Beneficial effects

[0015] The beneficial effects of the utility model are:

[0016] 1. The probe can be easily replaced. The operator only needs to press the pressing part to disassemble and replace it. While facilitating operation, it is also designed with a positioning groove and a positioning block that matches it, which can lock the installation position of the probe and prevent it from falling off. The spring installation and reset are simple and easy to operate, which can meet the requirements of various environments, and the size of the probe can be changed at any time.

[0017] 2. The probe motion platform can move freely in the X-axis and Y-axis directions, and is also equipped with positioning sensors to achieve precise positioning and positioning compensation, thereby improving the accuracy of probe detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0019] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0020] Figure 2 This is a schematic diagram of the structure of the installation shell of the utility model;

[0021] Figure 3 It is a schematic diagram of the structure of the probe of the utility model;

[0022] Figure 4 This is a schematic diagram of the installation part of the probe of the utility model;

[0023] Figure 5 It is a schematic diagram of the pressing part of the probe of the utility model;

[0024] 1-moving platform; 11-moving guide rail; 111-longitudinal guide rail; 112-transverse guide rail; 12-installing platform; 121-base; 122-positioning sensor; 123-installing shell; 1234-positioning groove; 2-probe; 21-probe head; 22-installing part; 221-shell; 2211-upper and lower bottom surfaces; 2212-slide groove; 23-pressing part; 231-pressing handle; 232-stop block; 233-insert piece; 234-positioning block. DETAILED DESCRIPTION

[0025] The utility model is further described with reference to the accompanying drawings, which is a probe motion platform for a nanopore sequencer.

[0026] As shown in the attached drawings, a probe motion platform for a nanopore sequencer includes a motion platform 1 and a probe 2. The motion platform 1 includes a motion guide rail 11 and a mounting platform 12. The mounting platform 12 is slidably mounted below the motion guide rail 11. The mounting platform 12 includes a base 121. Four positioning sensors 122 are fixedly mounted below the plane of the base 121. A mounting shell 123 is fixedly mounted at the center of the base 121. The mounting shell 123 is in a circular stepped shape, and a positioning groove 1234 is symmetrically opened at the center of the bottom circular ring. The probe 2 includes a probe head 21 and a mounting portion 22. The probe head 21 is fixedly mounted on the mounting portion 22. At the bottom of 22, the mounting portion 22 includes an integrally formed shell 221, the shell 221 includes an upper and lower bottom surface 2211, the upper and lower bottom surfaces 2211 are connected by a solid structure in the center, and a slide groove 2212 is provided, a pressing portion 23 is inserted inside the slide groove 2212, the pressing portion 23 includes a pressing handle 231, the upper part of the pressing handle 231 is a stopper 232, an insert 233 is integrally formed inside the stopper 232, the insert 233 is inserted inside the slide groove 2212, the upper part of the stopper 232 is a positioning block 234, the positioning block 234 cooperates with the positioning groove 1234, and a spring is fixedly connected to the upper end of the slide groove 2212 inside the stopper 232.

[0027] Furthermore, the motion guide rail 11 includes a longitudinal guide rail 111 and a transverse guide rail 112 , and the longitudinal guide rail 111 is slidably mounted on the transverse guide rail 112 .

[0028] Furthermore, the motion guide rail 11 is driven by a nanometer-scale micro motor.

[0029] Furthermore, the upper and lower bottom surfaces 2211 are in the shape of an I-shaped character.

[0030] Furthermore, the length of the positioning block 234 is greater than the thickness of the inner wall of the circular ring of the mounting shell 123 .

[0031] Furthermore, the edge of the stopper 232 is slightly wider than the minimum circular ring diameter at the bottom of the mounting housing 123 .

[0032] Further, the probe 2 is installed at the center position of the installation portion 22 .

[0033] The working principle of the utility model is as follows: when the probe 2 is working, the positioning motion platform 1 needs to be positioned through the motion guide 11 to achieve positioning. The motion guide 11 is driven by a nano-scale micro motor. When the longitudinal guide 111 and the transverse guide 112 reach the sample position respectively, the positioning sensor 122 analyzes whether the position light source is consistent. If it is consistent, the probe 2 performs sampling. If the position is inconsistent, the probe 2 will continue to repeat positioning under the movement of the motion platform 1 until it reaches the specified position.

[0034] When the probe 2 needs to be replaced, the operator needs to pinch the pressing parts 23 on both sides. The pressing part 23 includes a pressing handle 231, the upper part of the pressing handle 231 is a stopper 232, and the inside of the stopper 232 is integrally formed with an insert 233, the insert 233 is inserted into the inside of the slide groove 2212, the upper part of the stopper 232 is a positioning block 234, the positioning block 234 cooperates with the positioning groove 1234, and the inside of the stopper 232 is fixedly connected to the upper end of the slide groove 2212 with a spring; when the pressing handle 231 is pressed, the pressing part 23 as a whole moves closer to the center, and the positioning block 23 4 away from the positioning groove 1234, and at the same time, the stopper 232 also approaches inward, and its edge moves to a point smaller than the minimum circular ring diameter at the bottom of the installation shell 123, and the probe 2 can be pulled out; when replacing the probe 2, press the pressing handle 231 to insert the positioning block 234 to the horizontal position of the positioning groove 1234, release the pressing handle 231, and the pressing handle 231 moves outward under the action of the spring, and the positioning block 234 cooperates with the positioning groove 1234 and is fixed, and the stopper 232 also pops outward, and its edge is wider than the minimum circular ring diameter at the bottom of the installation shell 123, blocking the probe 2 from continuing to move inward. The installation and replacement steps of the probe 2 are now completed.

[0035] The embodiments described above are merely descriptions of preferred implementation modes of the present invention, and are not intended to limit the concept and scope of the present invention. Without departing from the design concept of the present invention, various modifications and improvements made to the technical solution of the present invention by ordinary personnel in this field should fall within the protection scope of the present invention. The technical contents for which protection is sought in the present invention have been fully recorded in the claims.

Claims

1. A probe motion platform for a nanopore sequencer, comprising a motion platform (1) and a probe (2), wherein the motion platform (1) comprises a motion guide rail (11) and a mounting platform (12), characterized in that: The installation platform (12) is slidably installed below the motion guide rail (11). The installation platform (12) includes a base (121). Four positioning sensors (122) are fixedly installed below the plane of the base (121). An installation shell (123) is fixedly installed at the exact center of the base (121). The installation shell (123) is in a ring stepped shape, and positioning grooves (1234) are symmetrically arranged at the center of the bottom ring. The probe (2) includes a probe head (21) and an installation part (22). The probe head (21) is fixedly installed at the bottom of the installation part (22). The installation part (22) includes an integrally formed shell (221). The shell (221) includes upper and lower bottom surfaces (2211). The centers of the upper and lower bottom surfaces (2211) are connected by a solid structure and are provided with a sliding groove (2212). A pressing part (23) is inserted into the sliding groove (2212). The pressing part (23) includes a pressing handle (231). The upper part of the pressing handle (231) is a stop block (232). An insertion piece (233) is integrally formed on the outside of the stop block (232). The insertion piece (233) is inserted into the sliding groove (2212). The upper part of the stop block (232) is a positioning block (234). The positioning block (234) is matched with the positioning groove (1234). A spring is fixedly connected between the inside of the stop block (232) and the upper end of the sliding groove (2212).

2. A probe motion platform for a nanopore sequencer according to claim 1, characterized in that: The motion guide rail (11) includes a longitudinal guide rail (111) and a transverse guide rail (112). The longitudinal guide rail (111) is slidably installed on the transverse guide rail (112).

3. A probe motion platform for a nanopore sequencer according to claim 2, characterized in that: The motion guide rail (11) is driven by a nanoscale micro motor.

4. The probe motion platform for a nanopore sequencer according to claim 1, characterized in that: The upper and lower bottom surfaces (2211) are in an "I" shape.

5. The probe motion platform for a nanopore sequencer according to claim 1, characterized in that: The length of the positioning block (234) is greater than the thickness of the inner wall of the ring of the installation shell (123).

6. The probe motion platform for a nanopore sequencer according to claim 1, characterized in that: The edge of the stop block (232) is wider than the minimum diameter of the bottom ring of the installation shell (123).

7. The probe motion platform for a nanopore sequencer according to claim 1, characterized in that: The probe (2) is installed at the central position of the installation part (22).

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