Special device for reinfusion of cell preparation

Abstract

The utility model relates to a device special for cell preparation feedback, and belongs to the technical field of medical instruments. The device comprises an infusion bag, an inner cavity is divided into a first cavity and a second cavity through a separation part, a first inlet and a first outlet are formed in the cavity wall of the first cavity, a second outlet is formed in the cavity wall of the second cavity, and normal saline is contained in the first cavity and the second cavity; the first filtering mechanism is provided with a third inlet and a third outlet, the third inlet is communicated with the cell preparation injection mechanism, and the third outlet is communicated with the first inlet; one end of the first soft catheter is communicated with the first outlet and is provided with a first switch; one end of the second soft catheter is communicated with the second outlet and is provided with a second switch; the first soft catheter and the second soft catheter are both communicated with the third soft catheter, a third switch is arranged on the third soft catheter, and the third soft catheter is connected with an infusion needle. By means of the structure, the device has the advantages of being easy, convenient and safe to use when used for cell preparation feedback.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical equipment, and particularly relates to a special device for reinfusion of cell preparations. Background Art

[0002] In recent years, with the continuous innovation and development of medical technology, biotechnology has received more and more attention. Cell therapy has also entered the fast lane of development and application. Cell preparations are different from drugs. They need to be filtered before reinfusion to remove metabolic waste generated during the culture process and prevent patients from developing thrombosis.

[0003] The commonly used reinfusion method is to suspend the cell preparation in 100-200ml of normal saline. Before the infusion, normal saline is used to open the intravenous channel. After the infusion of the cell preparation is completed, a large number of residual cells are attached to the inner wall of the infusion bag, resulting in cell waste. The current conventional practice is to use a syringe to draw normal saline and then inject it into the infusion bag to flush the residual cells on the bag wall, which easily increases the risk of contamination and the workload of nurses, and has the disadvantage of being inconvenient to use. Summary of the invention

[0004] The utility model provides a special device for reinfusion of cell preparations, which is used to solve the technical problem that the conventional cell preparation reinfusion devices are inconvenient to use.

[0005] The utility model is realized by the following technical scheme: a special device for reinfusion of cell preparations, comprising:

[0006] An infusion bag, wherein the inner cavity is divided into a first cavity and a second cavity by a partition, a first inlet and a first outlet are provided on the cavity wall of the first cavity, a second outlet is provided on the cavity wall of the second cavity, and physiological saline is contained in both the first cavity and the second cavity;

[0007] A first filtering mechanism has a third inlet and a third outlet, wherein the third inlet is connected to the cell preparation injection mechanism, and the third outlet is connected to the first inlet;

[0008] A first soft conduit, one end of which is connected to the first outlet, and the first soft conduit is provided with a first switch for controlling on and off;

[0009] A second flexible conduit, one end of which is connected to the second outlet, and a second switch for controlling on and off is provided on the second flexible conduit;

[0010] The third soft catheter, the other end of the first soft catheter and the other end of the second soft catheter are both connected to one end of the third soft catheter, the third soft catheter is provided with a third switch for controlling on and off, and the other end of the third soft catheter is connected to an infusion needle.

[0011] Furthermore, in order to better realize the utility model, it also includes a second filtering mechanism, having a fourth inlet and a fourth outlet, the first soft conduit includes a separated first section and a second section, the first section is connected and arranged between the fourth inlet and the first outlet, the second section is connected and arranged between the fourth outlet and one end of the third soft conduit, and the first switch is arranged on the second section.

[0012] Furthermore, in order to better realize the present utility model, the first filtering mechanism includes a first sterile filter membrane arranged between the third inlet and the third outlet, and the second filtering mechanism includes a second sterile filter membrane arranged between the fourth inlet and the fourth outlet, and the first sterile filter membrane and the second sterile filter membrane are both used to filter cell metabolic waste or cell clusters in the cell preparation.

[0013] Furthermore, in order to better realize the present invention, the pore size of the filtration holes on the first sterile filter membrane and the pore size of the filtration holes on the second sterile filter membrane are both 100 μm.

[0014] Furthermore, in order to better implement the utility model, the partition is a concave-convex buckle.

[0015] Furthermore, in order to better implement the present invention, the first inlet is blocked by a rubber plug, and a rubber cover for sealing is screwed onto the rubber plug.

[0016] Furthermore, in order to better implement the present invention, the amount of physiological saline in the first cavity is 100ml-200ml, and the amount of physiological saline in the second cavity is 100ml.

[0017] Furthermore, in order to better implement the utility model, a hook for hanging is fixedly provided on the top of the infusion bag.

[0018] Furthermore, in order to better implement the present invention, a Murphy's drip pot is connected to the third soft conduit.

[0019] Furthermore, in order to better implement the utility model, the cell preparation injection mechanism is a syringe.

[0020] Compared with the prior art, the utility model has the following beneficial effects:

[0021] The utility model provides a special device for reinfusion of cell preparations, comprising an infusion bag, a first filtering mechanism, a first soft catheter, a second soft catheter and a third soft catheter. The inner cavity of the infusion bag is divided into a first cavity and a second cavity by a partition. A first inlet and a first outlet are provided on the cavity wall of the first cavity, a second outlet is provided on the cavity wall of the second cavity, and physiological saline is contained in both the first cavity and the second cavity. The first filtering mechanism has a third inlet and a third outlet. The third inlet is connected to the cell preparation injection mechanism, and the third outlet is connected to the first inlet. One end of the first soft catheter is connected to the first outlet, and one end of the second soft catheter is connected to the second outlet. The first soft catheter and the second soft catheter are respectively provided with a first switch and a second switch. The other ends of the first soft catheter and the second soft catheter are both connected to one end of the third soft catheter. The other end of the third soft catheter is connected to an infusion needle, and the third soft catheter is provided with a third switch for controlling on and off.

[0022] Through the above structure, the cell preparation is injected into the above first cavity through the above cell preparation injection mechanism, the cell preparation is suspended in the physiological saline in the first cavity, and the cell preparation injected into the first cavity is filtered through the above first filtering mechanism, so that the cell preparation in the first cavity is purer and meets the specifications. When the cell preparation is reinfused to the patient, the above first switch is first closed and the second switch and the third switch are opened, so that the physiological saline in the second cavity first enters the patient's vein, so as to open the patient's venous access with the physiological saline, and then the second switch is closed and the first switch is opened and the third switch is ensured to be opened, and the cell preparation in the first cavity is passed through the above first soft catheter and the third switch. The soft catheter is reinfused into the patient's body to achieve the reinfusion of the cell preparation. When the reinfusion of the cell preparation is completed, the third switch is closed and the first switch and the second switch are opened, so that the first cavity and the second cavity are connected, and then the physiological saline in the second cavity is driven into the first cavity to flush the cavity wall of the first cavity, so that the cell preparation attached to the cavity wall of the first cavity falls off, and finally the second switch is closed and the first switch and the third switch are opened, so that the mixed liquid obtained after flushing is reinfused into the patient's body. In this way, the cell preparation on the cavity wall of the first cavity is flushed with the physiological saline in the infusion bag, and no contamination occurs, which is safer and more convenient to use. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0024] Figure 1It is a schematic diagram of the structure of a dedicated device for reinfusion of cell preparations provided in an embodiment of the utility model;

[0025] Figure 2 It is a schematic structural diagram of the dedicated device for reinfusion of cell preparations provided in an embodiment of the utility model when the first inlet is blocked by a rubber cover.

[0026] In the figure:

[0027] 1-infusion bag; 101-first cavity; 102-second cavity; 103-first inlet; 104-first outlet; 105-second outlet;

[0028] 2- separator;

[0029] 3-first filtering mechanism; 301-third inlet; 302-third outlet; 303-first sterile filter membrane;

[0030] 4-Syringe;

[0031] 5-first soft conduit; 501-first switch; 502-first exhaust assembly;

[0032] 6-second soft conduit; 601-second switch; 602-second exhaust assembly;

[0033] 7-third soft catheter; 701-third switch; 702-Murphy's drip pot;

[0034] 8-Infusion needle;

[0035] 9-second filtering mechanism; 901-fourth inlet; 902-fourth outlet; 903-second sterile filter membrane;

[0036] 10-Rubber plug;

[0037] 11- Rubber cover;

[0038] 12-Hook. DETAILED DESCRIPTION

[0039] In order to make the purpose, technical solution and advantages of the utility model clearer, the technical solution of the utility model will be described in detail below. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other implementation methods obtained by ordinary technicians in this field without creative work belong to the scope of protection of the utility model. Example

[0040] This embodiment provides a dedicated device for reinfusion of cell preparations, which is used to solve the disadvantage of inconvenient use of such devices in the prior art. The dedicated device for reinfusion of cell preparations comprises an infusion bag 1, a first filtering mechanism 3, a first soft catheter 5, a second soft catheter 6 and a third soft catheter 7, wherein:

[0041] The infusion bag 1 is a medical soft bag made of PVC. A partition 2 is provided in the inner cavity of the infusion bag 1, and the inner cavity of the infusion bag 1 is divided into a first cavity 101 and a second cavity 102 by the partition 2. A first inlet 103 and a first outlet 104 are provided on the cavity wall of the first cavity 101, and a second outlet 105 is provided on the cavity wall of the second cavity 102. The first inlet 103, the first outlet 104 and the second outlet 105 are all located at the bottom of the infusion bag 1. Physiological saline is contained in the first cavity 101 and the second cavity 102. The inner cavity of the infusion bag 1 is divided into two independent chambers by the partition 2, and physiological raw water is contained in the two independent chambers. Optionally, the partition 2 is a concave-convex buckle, so that when the two independent chambers need to be separated, the concave-convex buckle is buckled. When the concave-convex buckle is pulled apart, the two independent chambers are merged into one chamber. Optionally, the amount of physiological saline in the first cavity 101 is 100 ml-200 ml, and the amount of physiological saline in the second cavity 102 is 100 ml.

[0042] The first filtering mechanism 3 has a third inlet 301 and a third outlet 302, and the first filtering mechanism 3 is used to filter cell metabolic waste and cell clusters in the cell preparation. The third inlet 301 is connected to the cell preparation injection mechanism, and the cell preparation produced in the laboratory is injected into the first filtering mechanism 3 through the cell preparation injection mechanism, and the cell preparation filtered by the first filtering mechanism 3 enters the third outlet 302, and the third outlet 302 is connected to the first inlet 103, so that the cell preparation filtered by the first filtering mechanism 3 is injected into the first cavity 101. After the filtering action of the first filtering mechanism 3, the cell metabolic waste and cell clusters in the cell preparation entering the first cavity 101 are filtered out, so that the cell preparation in the first cavity 101 is purer. Optionally, the cell preparation injection mechanism is a syringe 4.

[0043] One end of the first soft catheter 5 is connected to the first outlet 104, and the first soft catheter 5 is provided with a first switch 501 for controlling the on-off. Thus, the on-off of the first soft catheter 5 is controlled by the control of the first switch 501. One end of the second soft catheter 6 is connected to the second outlet 105, and the second soft catheter 6 is provided with a second switch 601. The on-off of the second soft catheter 6 is controlled by the control of the second switch 601. The other ends of the first soft catheter 5 and the second soft catheter 6 are both connected to one end of the third soft catheter 7, and the other end of the third soft catheter 7 is connected to an infusion needle 8, and the third soft catheter 7 is provided with a third switch 701 for controlling the on-off. The infusion needle 8 is used for venous puncture of the patient. A Murphy's drip pot 702 is also provided in the third soft catheter 7. It should be noted that the first hose 5 in this embodiment is connected with a first exhaust assembly 502, and the second hose 6 in this embodiment is connected with a second exhaust assembly 602. The first exhaust assembly 502 and the second exhaust assembly 602 each include a tube body and an air valve disposed on the tube body and used to control the on and off of the tube body. The first hose 5 and the second hose 6 are actually both infusion tubes, and the first exhaust assembly 502 and the second exhaust assembly 602 are used to exhaust the two infusion tubes respectively.

[0044] Through the above structure, the cell preparation is injected into the above first cavity 101 through the above cell preparation injection mechanism, and the cell preparation is suspended in the physiological saline in the first cavity 101. The cell preparation injected into the first cavity 101 is filtered through the above first filtering mechanism 3, so that the cell preparation in the first cavity 101 is purer and meets the specifications. When the cell preparation is reinfused to the patient, the above first switch 501 is first closed and the second switch 601 and the third switch 701 are opened, so that the physiological saline in the second cavity 102 first enters the patient's vein, so as to open the patient's venous access with the physiological saline, and then the second switch 601 is closed and the first switch 501 is opened and the third switch 701 is ensured to be opened, and the cell preparation in the first cavity is reinfused into the patient through the above first soft catheter 5 and the third soft catheter 7 The patient's body is filled with the third switch 701, thereby realizing the reinfusion of the cell preparation. When the reinfusion of the cell preparation is completed, the third switch 701 is closed and the first switch 501 and the second switch 601 are opened, so that the first cavity 101 and the second cavity 102 are connected, and then the physiological saline in the second cavity 102 is driven into the first cavity 101 to flush the cavity wall of the first cavity 101, so that the cell preparation attached to the cavity wall of the first cavity 101 falls off, and finally the second switch 601 is closed and the first switch 501 and the third switch 701 are opened, so that the mixed liquid obtained after flushing is reinfused into the patient's body. In this way, the cell preparation on the cavity wall of the first cavity 101 is flushed with the physiological saline in the infusion bag 1, and no contamination occurs. It is safer and more convenient to use, and the workload of medical staff is reduced. It should be noted that during cleaning, the second cavity 102 is squeezed by hand so that the saline in the second cavity 102 smoothly enters the first cavity 101, and then the infusion bag 1 is gently shaken, and the cell preparation on the cavity wall of the first cavity 101 is cleaned. In addition, only part of the saline in the second cavity 102 is injected into the first cavity 101 during each cleaning, and then the first switch 501 and the second switch 601 are closed. At this time, the first switch 501, the second switch 601 and the third switch 701 are all closed, and the first cavity 101 forms a closed cavity. After one cleaning is completed, the first switch 501 and the second switch 602 are opened again, and then part of the saline in the second cavity 102 is injected into the first cavity 101 again. Repeat this operation many times.

[0045] Specifically, when in use, medical personnel do not need to insert an additional syringe 4 into the wall of the first cavity 101 to inject physiological saline into the first cavity 101 to clean the cell preparation attached to the wall of the first cavity 101. The device directly uses the physiological saline built into the second cavity 102 to clean the wall of the first cavity 101. The physiological saline built into the second cavity 102 is in a closed environment during the process of entering the first cavity 101, so it will not be contaminated.

[0046] An optional implementation of this embodiment is as follows: the first soft catheter 5 includes a separated first section and a second section, and a second filtering mechanism 9 is connected between the first section and the second section. Specifically, the second filtering mechanism 9 has a fourth inlet 901 and a fourth outlet 902, the first section is connected and arranged between the fourth inlet 901 and the first outlet 104, the second section is connected and arranged between the fourth outlet 902 and one end of the third soft catheter 7, and the first switch 501 is arranged on the second section. Through the second filtering mechanism 9, the cell preparation injected into the patient's body from the first cavity 101 is filtered, so that the cell preparation injected into the patient's body will not contain cell metabolic waste and cell clusters, thereby avoiding the patient from having thrombosis due to the injection of the cell preparation, and further improving safety. In this way, the device provided by the utility model better filters the cell metabolic waste and cell clusters in the cell preparation injected into the patient's body through the first filtering device and the second filtering device. Moreover, the second filter mechanism 9 is connected to the first section and the second section by plug-in, so the second filter mechanism 9 is easy to disassemble and assemble. When the second filter mechanism 9 loses its filtering effect, medical staff can quickly remove the failed second filter mechanism 9 and replace it with a new second filter mechanism 9.

[0047] Specifically, the first filtering mechanism 3 includes a first sterile filter membrane 303 disposed between the third inlet 301 and the third outlet 302, and the second filtering mechanism 9 includes a second sterile filter membrane 903 disposed between the fourth inlet 901 and the fourth outlet 902. The first sterile filter membrane 303 and the second sterile filter membrane 903 are both used to filter cell metabolic waste or cell clusters in the cell preparation. Optionally, the pore size of the filter holes of the first sterile filter membrane 303 and the pore size of the filter holes on the second sterile filter membrane 903 are both 100 μm.

[0048] An optional implementation of this embodiment is as follows: a rubber plug 10 is installed to seal the first inlet 103, and a rubber cover 11 for sealing is screwed on the rubber plug 10. When in use, the rubber cover 11 is removed, a needle is connected to the third outlet 302 of the first filtering mechanism 3, and the needle is inserted into the rubber plug 10, so that the third outlet 302 is connected to the first inlet 103, and after the needle is removed, the rubber plug 10 automatically seals the first inlet 103 by its own action, and finally the rubber cover 11 is covered on the rubber plug 10 to further seal the first inlet 103.

[0049] An optional implementation of this embodiment is as follows: a hook 12 is fixedly provided on the top of the infusion bag 1, and with the help of the hook 12, medical staff can conveniently hang the infusion bag 1 on the infusion stand.

[0050] The above is only a specific implementation of the utility model, but the protection scope of the utility model is not limited thereto. Any technician familiar with the technical field can easily think of changes or substitutions within the technical scope recorded in the utility model, which should be included in the protection scope of the utility model. Therefore, the protection scope of the utility model should be based on the protection scope of the claims.

Claims

1. A dedicated device for reinfusion of cell preparations, characterized in that: include: An infusion bag, wherein the inner cavity is divided into a first cavity and a second cavity by a partition, a first inlet and a first outlet are provided on the cavity wall of the first cavity, a second outlet is provided on the cavity wall of the second cavity, and physiological saline is contained in both the first cavity and the second cavity; A first filtering mechanism has a third inlet and a third outlet, wherein the third inlet is connected to the cell preparation injection mechanism, and the third outlet is connected to the first inlet; A first soft conduit, one end of which is connected to the first outlet, and the first soft conduit is provided with a first switch for controlling on and off; A second flexible conduit, one end of which is connected to the second outlet, and a second switch for controlling on and off is provided on the second flexible conduit; The third soft catheter, the other end of the first soft catheter and the other end of the second soft catheter are both connected to one end of the third soft catheter, the third soft catheter is provided with a third switch for controlling on and off, and the other end of the third soft catheter is connected to an infusion needle.

2. A dedicated device for reinfusion of cell preparations according to claim 1, characterized in that: It also includes a second filtering mechanism having a fourth inlet and a fourth outlet, the first soft conduit including a separated first section and a second section, the first section being connected and arranged between the fourth inlet and the first outlet, the second section being connected and arranged between the fourth outlet and one end of the third soft conduit, and the first switch being arranged on the second section.

3. A dedicated device for reinfusion of cell preparations according to claim 2, characterized in that: The first filtering mechanism includes a first sterile filter membrane arranged between the third inlet and the third outlet, and the second filtering mechanism includes a second sterile filter membrane arranged between the fourth inlet and the fourth outlet. The first sterile filter membrane and the second sterile filter membrane are both used to filter cell metabolic waste or cell clusters in the cell preparation.

4. A dedicated device for reinfusion of cell preparations according to claim 3, characterized in that: The pore size of the filtration holes on the first sterile filter membrane and the pore size of the filtration holes on the second sterile filter membrane are both 100 μm.

5. A dedicated device for reinfusion of cell preparations according to any one of claims 1 to 4, characterized in that: The partition is a concave-convex buckle.

6. A dedicated device for reinfusion of cell preparations according to any one of claims 1 to 4, characterized in that: The first inlet is blocked by a rubber plug, and a rubber cover for sealing is screwed onto the rubber plug.

7. A dedicated device for reinfusion of cell preparations according to any one of claims 1 to 4, characterized in that: The amount of physiological saline in the first chamber is 100ml-200ml, and the amount of physiological saline in the second chamber is 100ml.

8. A dedicated device for reinfusion of cell preparations according to any one of claims 1 to 4, characterized in that: A hook for hanging is fixedly arranged on the top of the infusion bag.

9. A dedicated device for reinfusion of cell preparations according to any one of claims 1 to 4, characterized in that: The third soft conduit is connected with a Murphy's drip pot.

10. A dedicated device for reinfusion of cell preparations according to any one of claims 1 to 4, characterized in that: The cell preparation injection mechanism is a syringe.

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